DR. LEONG KOK HOONG
Department of Pharmaceutical Chemistry
Faculty of Pharmacy
leongkh@um.edu.myView CV | |
Publons | |
Scopus Link | |
Biography | |
Dr. Leong research focus on investigating the mechanism of action of potent compounds toward developing new anticancer and antidiabetes drugs. His research adopts an in vitro approach using cell-based and enzymatic assays to identify the various cellular pathways modulated by a potent compound. The research outcome is to understand the mechanism of action of the compound, a prerequisite requirement in developing a new drug entity. In addition, he employs metabolomics to evaluate biomarkers in explaining the treatment outcomes or disease progression. International collaboration has geared his research towards cancer stem cells and utilizing zebrafish as an animal model for cancer. It is believed that cancer stem cells is a subset of cells in tumour that drives chemoresistance and relapse in cancer patients. Therefore, strategies to develop new chemotherapy against the subset of cells is of great interest to tackle the problem. |
Publication
Finance
Project Title | Progress | Status |
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Mechanistic Study On The Role Of Hypoxia-inducible Factor Prolyl-hydroxylases In Breast Cancer Tumourigenesis Using Selective Small Molecule Chemical Probes |
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Untrageted And Targeted Metabolomics Analysis Of Healthy And Hiv-infected Patient Blood Sample |
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Unravelling The Antineoplastic Mechanism Of Anilinoquinazoline Compound In Lung Cancer Stem Cells And Zebrafish |
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This information is generated from Research Grant Management System |
Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR
Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR
Separation of Antioxidant-Rich Alternanthera Sessilis Red Extracts by Sephadex LH-20 and Identification of Polyphenols Using HPLC-QToF-MS/MS.
Separation of Antioxidant-Rich Alternanthera Sessilis Red Extracts by Sephadex LH-20 and Identification of Polyphenols Using HPLC-QToF-MS/MS
Phytochemicals against cancer stem cells