Curriculum Vitae

DR. LEONG KOK HOONG

Senior Lecturer
  • Department of Pharmaceutical Chemistry
    Faculty of Pharmacy
  • +603-79676680

BIOGRAPHY


Dr. Leong research focus on investigating the mechanism of action of potent compounds toward developing new anticancer and antidiabetes drugs. His research adopts an in vitro approach using cell-based and enzymatic assays to identify the various cellular pathways modulated by a potent compound. The research outcome is to understand the mechanism of action of the compound, a prerequisite requirement in developing a new drug entity. In addition, he employs metabolomics to evaluate biomarkers in explaining the treatment outcomes or disease progression. International collaboration has geared his research towards cancer stem cells and utilizing zebrafish as an animal model for cancer. It is believed that cancer stem cells is a subset of cells in tumour that drives chemoresistance and relapse in cancer patients. Therefore, strategies to develop new chemotherapy against the subset of cells is of great interest to tackle the problem.

AREAS OF EXPERTISE


  • BIOPHARMACY
    Drug discovery, metabolomics and drug delivery

ACADEMIC QUALIFICATION


  • PHD (Biopharmacy), (Biopharmacy)
    Universiti Malaya (UM)
  • MST, (Pengurusan Alam Sekitar)
    Universiti Malaya (UM)
  • BSc(Hons), (Sains)
    University of Campbell, Buies Creek

ADMINISTRATIVE DUTIES


  • Task Force Member
    13 Jan 2023 - 12 Jan 2025 (University Malaya)
  • Coordinator
    01 Sep 2019 - 31 Dec 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Programme Coordinator
    01 Nov 2022 - 31 Dec 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Coordinator
    01 Aug 2020 - 31 Dec 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Coordinator
    03 Jan 2023 - 31 Dec 2023 (University Malaya)
  • Faculty HPLC/LCMS Lab Advisor
    17 Sep 2019 - 31 Dec 2022 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Quality Manager
    16 Sep 2019 - 31 Jan 2022 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Faculty Chief Liaison Officer for International Relation Office, University Malaya
    14 Oct 2019 - 31 Dec 2021 (University Malaya)
  • Manager
    19 Oct 2020 - 20 Oct 2021 (Dean Office, Faculty of Pharmacy)
  • Committee Member for Faculty of Medicine Milestone Book
    11 Aug 2014 - 31 Dec 2014 (Dean Office, Faculty of Medicine)
  • Student Empowerment and Research Unit (SERU) SoftSkills Facilitator
    28 Feb 2014 - 03 May 2014 (University Malaya)

MEMBERSHIPS


  • LABORATORY ANIMAL SCIENCE ASSOCIATION OF MALAYSIA, MEMBER
    2023 to 2024 (National)
  • LABORATORY ANIMAL SCIENCE ASSOCIATION OF MALAYSIA , MEMBER
    2018 to 2022 (National)
  • LEAD AUDITOR FOM UNIVERSITY OF MALAYA, AUDITOR
    2018 to 2018 (University)

AWARD AND STEWARDSHIP


  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2021 (University)
  • Visiting Researcher
    Institute of Medicinal Plant Development & Peking Union Medical College, Beijing, China., 2019 (International)
  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2018 (University)
  • Visiting Lecturer
    Kyushu University, Japan, 2017 (International)
  • Visiting Lecturer
    Kyushu University, 2016 (International)
  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2015 (University)
  • Japan-Asia Youth Exchange Program in Science, Japan Science and Technology Agency
    Japan Science and Technology Agency, 2015 (International)

PUBLICATIONS


Article in Journal
WoS
  1. Hwong, Chia Shing; Leong, Kok Hoong; Aziz, Azlina Abdul; Kong, Kin Weng (2023). Separation of Antioxidant-Rich Alternanthera Sessilis Red Extracts by Sephadex LH-20 and Identification of Polyphenols Using HPLC-QToF-MS/MS, CHEMISTRY & BIODIVERSITY. . doi:10.1002/cbdv.202300215
  2. Chiba, Yuya; Okada, Kotaro; Hayashi, Yoshihiro; Leong, Kok Hoong; Kumada, Shungo; Onuki, Yoshinori (2022). Characterization of the Salt and Free Base of Active Pharmaceutical Ingredients Based on NMR Relaxometry Measured by Time Domain NMR, CHEMICAL & PHARMACEUTICAL BULLETIN. 70(2), 162-168
  3. Hazli, Ummi Husni Aminah Mohd; Hwong, Chia Shing; Abdul-Aziz, Azlina; Mat-Junit, Sarni; Leong, Kok Hoong; Kong, Kin Weng (2022). Effects of Alternanthera sessilis Red leaf extracts on hydrogen peroxide- induced oxidative stress in HepG2 cells and identification of phytochemicals using HPLC-QToF-MS/MS, SOUTH AFRICAN JOURNAL OF BOTANY. 151, 440-450. doi:10.1016/j.sajb.2022.04.056
  4. Hwong, Chia Shing; Leong, Kok Hoong; Aziz, Azlina Abdul; Junit, Sarni Mat; Noor, Suzita Mohd; Kong, Kin Weng (2022). Alternanthera sessilis: Uncovering the nutritional and medicinal values of an edible weed, JOURNAL OF ETHNOPHARMACOLOGY. 298. doi:10.1016/j.jep.2022.115608
  5. Keflee, Rashidi Dzul; Leong, Kok Hoong; Ogawa, Satoshi; Bignon, Jerome; Chan, Mun Chiang; Kong, Kin Weng (2022). Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer, BIOCHEMICAL PHARMACOLOGY. 205. doi:10.1016/j.bcp.2022.115262
  6. Sivasothy, Yasodha; Leong, Kok Hoong; Loo, Kong Yong; Wahab, Siti Mariam Adbul; Othman, Muhamad Aqmal; Awang, Khalijah (2022). Giganteone A and malabaricone C as potential pharmacotherapy for diabetes mellitus, NATURAL PRODUCT RESEARCH. . doi:10.1080/14786419.2021.1885405
  7. Wong, Chen Yuan; Leong, Kok Hoong; He, Xuemei; Zheng, Fengjing; Sun, Jian; Wang, Zhenxing; Heh, Choon Han; Kong, Kin Weng (2022). Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation, FOOD BIOSCIENCE. 46. doi:10.1016/j.fbio.2022.101557
  8. Yap, Siew Hwei; Lee, Cheng Siang; Furusho, Aogu; Ishii, Chiharu; Shaharudin, Syahirah; Zulhaimi, Nurul Syuhada; Kamarulzaman, Adeeba; Kamaruzzaman, Shahrul Bahyah; Mita, Masashi; Leong, Kok Hoong; Hamase, Kenji; Rajasuriar, Reena (2022). Plasma d-amino acids are associated with markers of immune activation and organ dysfunction in people with HIV, AIDS. 36(7), 911-921. doi:10.1097/QAD.0000000000003207
  9. Abdulwahab, M. K., Tan, K. H., Dzulkeflee, R., Leong, K. H., Heh, C. H., & Ariffin, A. (2021). In-silico Studies of the Antiproliferative Activity of New Anilinoquinazoline Derivatives Against NSCLC Cells. Journal of Molecular Structure, 1228, 13. doi: 10.1016/j.molstruc.2020.129786
  10. Ohgi, Kosuke; Hayashi, Yoshihiro; Tsuji, Takahiro; Ito, Terushi; Leong, Kok Hoong; Usuda, Shui; Kumada, Shungo; Okada, Kotaro; Onuki, Yoshinori (2021). Time-domain NMR analysis for the determination of water content in pharmaceutical ingredients and wet granules, INTERNATIONAL JOURNAL OF PHARMACEUTICS. 604. doi:10.1016/j.ijpharm.2021.120770
  11. Usuda, S., Masukawa, N., Leong, K. H., Okada, K., & Onuki, Y. (2021). Effects of Manufacturing Process Variables on the Tablet Weight Variation of Mini-tablets Clarified by a Definitive Screening Design. Chemical & Pharmaceutical Bulletin, 69(9), 896-904. doi: 10.1248/cpb.c21-00427
  12. Abdulwahab, M. K., Dzulkeflee, R., Han, T. K., Ruslan, R. A., Leong, K. H., Heh, C. H., & Ariffin, A. (2020). Synthesis, In Vitro Antiproliferative Activity, and In Silico Studies of New Anilinoquinazoline Derivatives as Potential AntitumorAgents. Russian Journal of General Chemistry, 90(12), 2410-2418. doi: 10.1134/s1070363220120294
  13. Arulnathan, S. B., Leong, K. H., Ariffin, A., Kareem, H. S., & Cheah, K. K. H. (2020). Activation of Intrinsic Apoptosis and G1 Cell Cycle Arrest by a Triazole Precursor, N-(4-chlorophenyl)-2-(4-(3,4,5-trimethoxybenzyloxy)benzoyl)-hydrazinecar bothioamide in Breast Cancer Cell Line. Anti-cancer agents in medicinal chemistry, 20(9), 1072-1086. doi: 10.2174/1871520620666200318100051
  14. Chan, Z. C. K., Leong, K. H., Kareem, H. S., Norazit, A., Noor, S. M., Ariffin, A. (2020). Activation of death receptor, DR5 and mitochondria-mediated apoptosis by a 3,4,5-trimethoxybenzyloxy derivative in wild-type and p53 mutant colorectal cancer cell lines. Naunyn-Schmiedebergs Archives of Pharmacology, 393(3), 405-417. doi: 10.1007/s00210-019-01730-2
  15. Hayashi, Y., Shirotori, K., Kosugi, A., Kumada, S., Leong, K. H., Okada, K., & Onuki, Y. (2020). A Precise Prediction Method for the Properties of API-Containing Tablets Based on Data from Placebo Tablets. Pharmaceutics, 12(7), 13. doi: 10.3390/pharmaceutics12070601
  16. Kosugi, A., Leong, K. H., Tsuji, H., Hayashi, Y., Kumada, S., Okada, K., & Onuki, Y. (2020). Characterization of Powder- and Tablet Properties of Different Direct Compaction Grades of Mannitol Using a Kohonen Self-organizing Map and a Lasso Regression Model. Journal of Pharmaceutical Sciences, 109(8), 2585-2593. doi: 10.1016/j.xphs.2020.05.010
  17. Kosugi, A., Leong, K. H., Urata, E., Hayashi, Y., Kumada, S., Okada, K., & Onuki, Y. (2020). Effect of Different Direct Compaction Grades of Mannitol on the Storage Stability of Tablet Properties Investigated Using a Kohonen Self-Organizing Map and Elastic Net Regression Model. Pharmaceutics, 12(9), 14. doi: 10.3390/pharmaceutics12090886
  18. Lau, B. F., Kong, K. W., Leong, K. H., Sun, J., He, X. M., Wang, Z. X., . . . Ismail, A. (2020). Banana inflorescence: Its bio-prospects as an ingredient for functional foods. Trends in Food Science Technology, 97, 14-28. doi: 10.1016/j.tifs.2019.12.023
  19. Ougi, K., Okada, K., Leong, K. H., Hayashi, Y., Kumada, S., & Onuki, Y. (2020). Effect of the molecular mobility of water adsorbed by disintegrants on storage-induced hydrolytic degradation of acetylsalicylic acid incorporated into tablets under humid conditions. European Journal of Pharmaceutical Sciences, 154, 10. doi: 10.1016/j.ejps.2020.105502
  20. Tan, H. M., Leong, K. H., Song, J., Sufian, N., Hazli, U., Chew, L. Y., & Kong, K. W. (2020). Antioxidant and LC-QToF-MS/MS analysis of polyphenols in polar and non-polar extracts from Strobilanthes crispus and Clinacanthus nutans. International Food Research Journal, 27(5), 903-914.
  21. Tiamas, S. G., Daressy, F., Abou Samra, A., Bignon, J., Steinmetz, V., Litaudon, M., . . . Roussi, F. (2020). Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2. Bioorganic Medicinal Chemistry Letters, 30(7), 5. doi: 10.1016/j.bmcl.2020.127003
  22. Ito, T., Okada, K., Leong, K. H., Hirai, D., Hayashi, Y., Kumada, S., . . . Onuki, Y. (2019). A Time-Domain NMR Study of the State of Water in Wet Granules with Different Fillers and Its Contribution to the Wet Granulation Process and to the Characteristics of Granules. Chemical Pharmaceutical Bulletin, 67(3), 271-276.
  23. Loo, K. Y., Leong, K. H., Sivasothy, Y., Ibrahim, H., Awang, K. (2019). Molecular Insight and Mode of Inhibition of alpha-Glucosidase and alpha-Amylase by Pahangensin A from Alpinia pahangensis Ridl. Chemistry Biodiversity, 16(6), 8. doi:10.1002/cbdv.201900032
  24. Sahoo, P., Leong, K. H., Nyamathulla, S., Onuki, Y., Takayama, K., Chung, L. Y. (2019). Chitosan complexed carboxymethylated iota-carrageenan oral insulin particles: Stability, permeability and in vivo evaluation. Materials Today Communications, 20, 9. doi:10.1016/j.mtcomm.2019.100557
  25. Thavoncharoensub, N., Maruyama, K., Heh, C. H., Leong, K. H., Shi, H., Shigematsu, Y., . . . Taniguchi, Y. Synthesis of gamma-N-modified 8-oxo-2-deoxyguanosine triphosphate and its characterization. Nucleosides Nucleotides Nucleic Acids, 12. doi:10.1080/15257770.2019.1586919
  26. Liew, S. Y., Looi, C. Y., Paydar, M., Cheah, F. K., Leong, K. H., Wong, W. F., Mustafa, M. R., Litaudon, M., Awang, K. (2014). Subditine, a New Monoterpenoid Indole Alkaloid from Bark of Nauclea subdita (Korth.) Steud. Induces Apoptosis in Human Prostate Cancer Cells, Plos One. 9(2), 13
  27. Sivasothy, Y., Zachariah, C. C. K., Leong, K. H., John, S. K. S., Ibrahim, H., Awang, K. (2014). A novel heptacyclic diterpene from Alpinia pahangensis Ridley, a wild ginger endemic to Malaysia, Tetrahedron Letters. 55(45), 6163-6166
  28. Zahari, A., Cheah, F. K., Mohamad, J., Sulaiman, S. N., Litaudon, M., Leong, K. H., Awang, K. (2014). Antiplasmodial and Antioxidant Isoquinoline Alkaloids from Dehaasia longipedicellata, Planta Medica. 80(7), 599-603
  29. Azmi, M. N., Din, M. F. M., Kee, C. H., Suhaimi, M., Ping, A. K., Ahmad, K., Nafiah, M. A., Thomas, N. F., Mohamad, K., Hoong, L. K., Awang, K. (2013). Design, Synthesis and Cytotoxic Evaluation of o-Carboxamido Stilbene Analogues, International Journal of Molecular Sciences. 14(12), 23369-23389
  30. Kim, R. P. T., Bihud, V., Bin Mohamad, K., Leong, K. H., bin Mohamad, J., bin Ahmad, F., Hazni, H., Kasim, N., Halim, S. N. A., Awang, K. (2013). Cytotoxic and Antioxidant Compounds from the Stem Bark of Goniothalamus tapisoides Mat Salleh, Molecules. 18(1), 128-139
  31. Looi, C. Y., Arya, A., Cheah, F. K., Muharram, B., Leong, K. H., Mohamad, K., Wong, W. F., Rai, N., Mustafa, M. R. (2013). Induction of Apoptosis in Human Breast Cancer Cells via Caspase Pathway by Vernodalin Isolated from Centratherum anthelminticum (L.) Seeds, Plos One. 8(2), 20
  32. Looi, C. Y., Moharram, B., Paydar, M., Wong, Y. L., Leong, K. H., Mohamad, K., Arya, A., Wong, W. F., Mustafa, M. R. (2013). Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways, Bmc Complementary and Alternative Medicine. 13, 14
  33. Awang, K., Loong, X. M., Leong, K. H., Supratman, U., Litaudon, M., Mukhtar, M. R., Mohamad, K. (2012). Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae), Fitoterapia. 83(8), 1391-1395
  34. Sivasothy, Y., Hadi, A. H. A., Mohamad, K., Leong, K. H., Ibrahim, H., Sulaiman, S. F., Ooi, K. L., Awang, K. (2012). Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff, Bioorganic Medicinal Chemistry Letters. 22(11), 3831-3836
  35. Leong, K. H., Chung, L. Y., Noordin, M. I., Mohamad, K., Nishikawa, M., Onuki, Y., et al. (2011). Carboxymethylation of kappa-carrageenan for intestinal-targeted delivery of bioactive macromolecules, Carbohydrate Polymers. 834(1507-1515), Article
  36. Leong, K. H., Chung, L. Y., Noordin, M. I., Onuki, Y., Morishita, M., Takayama, K. (2011). Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin delivery, Carbohydrate Polymers. 862(555-565), Article
Scopus
  1. Hwong C.S., Leong K.H., Aziz A.A., Kong K.W. (2023). Separation of Antioxidant-Rich Alternanthera Sessilis Red Extracts by Sephadex LH-20 and Identification of Polyphenols Using HPLC-QToF-MS/MS, Chemistry and Biodiversity. . doi:10.1002/cbdv.202300215
  2. Idris N., Leong K.H., Wong E.H., Abdul Rahim N. (2023). Unveiling synergism of polymyxin B with chloramphenicol derivatives against multidrug-resistant (MDR) Klebsiella pneumoniae, Journal of Antibiotics. . doi:10.1038/s41429-023-00659-2
  3. Tsuji T., Ono T., Taguchi H., Leong K.H., Hayashi Y., Kumada S., Okada K., Onuki Y. (2023). Continuous Monitoring of the Hydration Behavior of Hydrophilic Matrix Tablets Using Time-Domain NMR, Chemical & pharmaceutical bulletin. 71(7), 576-583. doi:10.1248/cpb.c23-00214
  4. Yap C.H., Mat Junit S., Abdul Aziz A., Leong K.H., Hwong C.S., Kong K.W. (2023). Modulation of lipid metabolism-associated genes by Alternanthera sessilis (red) extracts and identification of potential lipid-lowering phytochemicals using HPLC-QToF-MS/MS, South African Journal of Botany. 160, 705-714. doi:10.1016/j.sajb.2023.07.055
  5. Chiba Y., Okada K., Hayashi Y., Leong K.H., Kumada S., Onuki Y. (2022). Characterization of the Salt and Free Base of Active Pharmaceutical Ingredients Based on NMR Relaxometry Measured by Time Domain NMR, Chemical and Pharmaceutical Bulletin. 70(2), 162-168. doi:10.1248/cpb.c21-00975
  6. Dzul Keflee R., Leong K.H., Ogawa S., Bignon J., Chan M.C., Kong K.W. (2022). Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer, Biochemical Pharmacology. 205. doi:10.1016/j.bcp.2022.115262
  7. Sivasothy Y., Leong K.H., Loo K.Y., Adbul Wahab S.M., Othman M.A., Awang K. (2022). Giganteone A and malabaricone C as potential pharmacotherapy for diabetes mellitus, Natural Product Research. 36(6), 1581-1586. doi:10.1080/14786419.2021.1885405
  8. Wong C.Y., Leong K.H., He X., Zheng F., Sun J., Wang Z., Heh C.H., Kong K.W. (2022). Phytochemicals of six selected herbal plants and their inhibitory activities towards free radicals and glycation, Food Bioscience. 46. doi:10.1016/j.fbio.2022.101557
  9. Ohgi, K., Hayashi, Y., Tsuji, T., Ito, T., Leong, K. H., Usuda, S., . . . Onuki, Y. (2021). Time-domain NMR analysis for the determination of water content in pharmaceutical ingredients and wet granules. International Journal of Pharmaceutics, 604. doi: 10.1016/j.ijpharm.2021.120770
  10. Usuda, S., Masukawa, N., Leong, K. H., Okada, K., & Onuki, Y. (2021). Effects of Manufacturing Process Variables on the Tablet Weight Variation of Mini-tablets Clarified by a Definitive Screening Design. Chemical and Pharmaceutical Bulletin, 69(9), 896-904. doi: 10.1248/cpb.c21-00427
  11. Abdulwahab M.K., Dzulkeflee R., Han T.K., Ruslan R.A., Leong K.H., Heh C.H., Ariffin A. (2020). Synthesis, In Vitro Antiproliferative Activity, and In Silico Studies of New Anilinoquinazoline Derivatives as Potential AntitumorAgents, Russian Journal of General Chemistry. 90(12), 2410-2418. doi:10.1134/S1070363220120294
Others
  1. Chia SH, Leong KH, Aziz AA, Kong KW (2023) Separation of Antioxidant-Rich Alternanthera Sessilis Red Extracts by Sephadex LH-20 and Identification of Polyphenols Using HPLC-QToF-MS/MS. Chemistry & Biodiversity. e202300215.
  2. Abdulwahab MK, Tan KH, Dzulkeflee R, Leong KH, Heh CH, Ariffin A (2021) In silico studies of the antiproliferative activity of new anilinoquinazoline derivatives against NSCLC cells. Journal of Molecular Structure. 1228:129786.
  3. Nooraqilah Che Rozenan, Nor Hisam Zamakshshari, Leong Kok Hoong, Najihah Mohd Hashim, Khadher Ahmad, Munirah Abd Razzak, Zulkifli Mohd Yusof, Khalijah Awang, Abd Aziz Ismail and Rozana Othman (2021). Biological And Analytical Investigations On Selected Malaysian Medicinal Plants As Potential Anti-Diabetics And Anti-Oxidants. Sains Malaysiana, 50 (9). pp. xxx-xxx.
  4. Sivasothy, Y., Leong, K. H., Loo, K. Y., Wahab, S. M. A., Othman, M. A., & Awang, K. (2021). Giganteone A and malabaricone C as potential pharmacotherapy for diabetes mellitus. 16, 1-6.
  5. Abdulwahab MK, Dzulkeflee R, Han TK, Ruslan RA, Leong KH, Heh CH, Ariffin A (2020) Synthesis, in vitro antiproliferative activity, and in silico studies of new anilinoquinazoline derivatives as potential antitumour agents. Russian Journal of General Chemistry. 90(12) 1-9.
  6. Abdulwahab, M. K., Dzulkeflee, R., Han, T. K., Ruslan, R. A., Leong, K. H., Heh, C. H., & Ariffin, A. (2020). Synthesis, In Vitro Antiproliferative Activity, and In Silico Studies of New Anilinoquinazoline Derivatives as Potential AntitumorAgents. Russ. J. Gen. Chem., 90(12), 2410-2418. doi:10.1134/S1070363220120294
  7. Arulnathan SB, Leong KH, Ariffin A, Kareem HS, Cheah KKH (2020) Activation of intrinsic apoptosis and G1 cell cycle arrest by a triazole precursor, N-(4-chlorophenyl)-2-(4-(3,4,5-trimethoxybenzyloxy)benzoyl)-hydrazinecarbothioamide in breast cancer cell line. Anti-Cancer Agents in Medicinal Chemistry. 20(9):2020.
  8. Kosugi A, Leong KH, Tsuji H, Hayashi Y, Kumada S, Okada K, Onuki Y (2020) Characterization of power-and tablet properties of different direct compaction grades of mannitol using kohonen self-organizing map and a lasso regression model. Journal of Pharmaceutical Sciences. Article In Press.
  9. Lau, B.F., Kong, K.W., Leong, K.H., Sun, J., He, X., Wang, Z., Mustafa, M.R., Ling, T.C., & Ismail, A., (2020). Banana inflorescence: Its bio-prospects as an ingredient for functional foods. Trends in Food Science & Technology, 97, 14-28.
  10. Loo KY, Leong KH, Sivasothy Y, Ibrahim H, Awang K (2019) Molecular insight and mode of inhibition of glucosidase and amylase by Pahangensin A from Alpinia pahangensis Ridl. Chemistry and Biodiversity. 16,e1900032.
  11. Sahoo, P., Leong, K. H., Nyamathulla, S., Onuki, Y., Takayama, K., Chung, L. Y. (2019). Chitosan complexed carboxymethylated iota-carrageenan oral insulin particles: Stability, permeability and in vivo evaluation. Materials Today Communications. 20, 100557. Doi: 10.1016/j.mtcomm.2019.100557
  12. Thavoncharoensub N, Maruyama K, Heh CH, Leong KH, Shi H, Shigematsu Y, Sasaki S, Taniguchi Y (2019) Synthesis of c-N-modified 8-oxo-2 -deoxyguanosine triphosphate and its characterization. Nucleosides, Nucleotides and Nucleic Acids. 38(8), 578-589.
  13. Foo Kit Cheah, Kok Hoong Leong, Noel Francis Thomas, Hui Kee Chin, Azhar Ariffin and Khalijah Awang. (2018). Resveratrol analogue, (E)-N-(2-(4-methoxystyryl) phenyl) furan-2-carboxamide induces G2/M cell cycle arrest through the activation of p53 p21CIP1/WAF1 in human colorectal HCT116 cells. Apoptosis, DOI:10.1007/s10495-018-1457-8
  14. Ito T, Okada K, Leong KH, Hirai D,Hayashi Y, Kumada S, Kosugi A, Onuki Y (2018) A time-domain NMR study of the state of water in wet granules with different fillers and its contribution to the wet granulation process and to the characteristics of granules. Chemical and Pharmaceutical Bulletin, 67(3):271-276.
  15. Haque, A. K. M. M., Leong, K. H., Lo, Y. L., Awang, K., Nagoor, N. H. (2017). In vitro inhibitory mechanisms and molecular docking of 1'-S'-1'-acetoxychavicol acetate on human cytochrome P450 enzymes. Phytomedicine, 31, 1-9.
  16. Leong KH, Mahdzir MA, Din MFM, Awang K, Tanaka Y, Kulkeaw K, Ishitani T, Sugiyama D. 2016. Induction of Intrinsic Apoptosis in Leukaemia Stem Cells and in Vivo Zebrafish Model by Betulonic Acid Isolated from Walsura pinnata Hassk (Meliaceae). Phytomedicine 26(2017) pp: 11-21.
  17. Sahoo P, Leong KH, Nyamathulla S, Onuki Y, Takayama K, Chung LY (2017) Optimization of pH-responsive carboxymethylated iota-carrageenan chitosan nanoparticles for oral insulin delivery using response surface methodology. Reactive and Functional Polymers, 19, 145-155. Doi: 10.1016/j.reactfunctpolym.2017.08.014.
  18. Yap SH, NK Abdullah, McStea M, Takayama K, Chong ML, Crisci E, Larsson M, Azwa I, Kamarulzaman A, Leong KH, Woo YL, Rajasuriar R. HIV/Human herpesvirus co-infections: impact on tryptophan-kynurenine pathway and immune reconstitution. PlosOne 2017; 12 (10): e186000.
  19. Leong KH, Looi CY, Loong X-M, Cheah FK, Supratman U, Litaudon M , Mustafa MR, Awang K (2016) Cycloart-24-ene-26-ol-3-one, a new cycloartane isolated from leaves of Aglaia exima triggers tumour necrosis factor-receptor 1-mediated caspase-dependent apoptosis in colon cancer cell line. PLoS One.
  20. Nazarbahjat N., Ariffin A., Abdullah Z., Abdulla M.A., Shia J.K.S., Leong K.H. (2016) Synthesis, characterization, drug-likeness properties and determination of the in vitro antioxidant and cytotoxic activities of new 1,3,4-oxadiazole derivatives. Medicinal Chemistry Research. 1: 1-15
  21. Sivasothy Y, Loo KH, Leong KH, Litaudon M, Awang K (2015). A potent alpha-glucosidase inhibitor from Myristica cinnamomea King. Phytochemistry. 122: 265-269.
  22. Azmi,M.N., Geny,C., Leverrier, A.,Litaudon, M., Dumontet, V.,Birlirakis, N., Gueritte,F.,Leong,K.H., Halim, S.N.A.,Mohamad, K.,Awang, K. (2014) Kingianic Acids A G, Endiandric Acid Analogues from Endiandra kingiana. Molecules. 19:1732-1747.
  23. Liew,S.Y., Looi, C.Y., Paydar,M., Cheah,F.K.,Leong,K.H., Wong, W.F., Mustafa, M.R., Litaudon, M (2014). Subditine, a new monoterpenoid indole alkaloid from bark of nauclea subdita (Korth.) steud. induces apoptosis in human prostate cancer cells. PLoS One. 9(2):e87286.
  24. Sivasothy Y., Zachariah C.C.K., Leong K.H., John S.K.S., Ibrahim H., Awang K. (2014) A novel heptacyclic diterpene from Alpinia pahangensis Ridley, a wild ginger endemic to Malaysia. Tetrahedron Letters.55 (45): 6163 6166. doi:http://dx.doi.org/10.1016/j.tetlet.2014.08.115
  25. Kim, R.P.T., Bihud, V., Mohamad, K., Leong, K.H., Mohamad, J., Ahmad, F., Hazni, H., Kasim, N., Halim, S.N.A., Awang, K. (2013) Cytotoxic and antioxidant compounds from the stem bark of Goniothalamus tapisoides Mat Salleh. Molecules. 18:128-139.
  26. Looi C.Y, Moharram B.,Paydar M.,Wong L.Y.,Leong K.H., Mohamad K., Arya A.,Wong W.F. and Mustafa M.R. (2013) Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways. BMC Complementary and Alternative Medicine. 13:166.
  27. Awang, K., Loong, X.-M, Leong, K.H., Supratman, U., Litaudon, M., Mukhtar, M.R., Mohamad, K. 2012. Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae). Fitoterapia. 83:1391-1395.
  28. Sivasothy, Y., Hadi, A.A., Mohamad, K., Hoong, L. K., Ibrahim, H., Sulaiman, S. F., Ooi, K. L., Awang, K. (2012) Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff. Bioorganic & Medicinal Chemistry Letters. 22(11):3831-3836.
  29. Leong, K. H., Chung, L. Y., Noordin, M. I., Mohamad, K., Nishikawa, M., Onuki, Y., Morishita, M., Takayama, K. (2011) Carboxymethylation of kappa-carrageenan for intestinal-targeted delivery of bioactive macromolecules. Carbohydrate Polymers. 83, 1507-1515.
  30. Leong, K. H., Chung, L. Y., Noordin, M. I., Onuki, Y., Morishita, M., Takayama, K. (2011) Lectin-functionalized carboxymethylated kappa-carrageenan microparticles for oral insulin. Carbohydrate Polymers. 86, 555-565.
  31. Leong, K. H., Benjamin, T. L. L., Mustafa, M. A. (2007) Contamination levels of selected organochlorine and organophosphate pesticides in the Selangor river, Malaysia between 2002 to 2003. Chemosphere. 66: 1153- 1159.
Chapter in Books
  1. Leong K.H., Kong K.W., Chung L.Y. (2018) Phytochemicals against cancer stem cells. In: Akhtar M., Swamy M. (Eds) Anticancer plants: Properties and Application. (pp. 559-582) Springer, Singapore

RESEARCH PROJECT


National
  1. 2022 - 2024, Fundamental Research Grant Scheme (FRGS)
    Design, Synthesis And Biological Activities Of Quinazoline-carboxamide Derivatives As Potential Drug Candidates To Overcome Resistance To Egfr Inhibitors ( Co-Researcher)
  2. 2022 - 2024, Others MOHE - Top 100 (IIRG)-FNW
    WP2: Development of Novel Therapeutic Agent and Delivery Method for Lung Cancer ( Co-Researcher)
  3. 2019 - 2023, Fundamental Research Grant Scheme (FRGS)
    Impact Of Gut Microbiota On Systemic D-amino Acids And Its Biological Relevance In Aging ( Co-Researcher)
  4. 2019 - 2023, Fundamental Research Grant Scheme (FRGS)
    Unravelling The Hypolipidaemic Mechanism Of Alternanthera Sessilis In Human Hepatoma Cells Using Lipidomic Approaches ( Co-Researcher)
  5. 2019 - 2023, Fundamental Research Grant Scheme (FRGS)
    Mechanistic Study On The Role Of Hypoxia-inducible Factor Prolyl-hydroxylases In Breast Cancer Tumourigenesis Using Selective Small Molecule Chemical Probes ( Co-Researcher)
  6. 2020 - 2023, RU Geran - Fakulti Program
    Optimising Polymyxin Combination Therapy For Men's Health Related Conditions ( Co-Researcher)
  7. 2020 - 2023, Others MOHE - Top 100 (IIRG)-HWB
    Serum And Salivary Biomarkers Of Oxidative And Nitrative Stress And Susceptibility To Genetic Damage In Oral Leukoplakia ( Co-Researcher)
  8. 2019 - 2022, RU Geran - Fakulti Program
    An Investigation Into The Effect Of Clinical Hif Prolyl-hydroxylase Inhibitors On Human Lung Cancer Progression ( Co-Researcher)
  9. 2019 - 2022, Fundamental Research Grant Scheme (FRGS)
    Unravelling The Antineoplastic Mechanism Of Anilinoquinazoline Compound In Lung Cancer Stem Cells And Zebrafish ( Principal Investigator(PI))
  10. 2019 - 2021, Fundamental Research Grant Scheme (FRGS)
    In Silico Self-evolving Peptides Algorithm For The Discovery Of Potential Peptide Inhibitor Against Alpha-amylase And Alpha-glucosidase ( Co-Researcher)
  11. 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - AFR (Frontier Science)
    Synthesis And Antitumor Activity Of Quinazoline ( Co-Researcher)
  12. 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - AFR (Frontier Science)
    Investigation Of The Mechanism Of Action Of Quinazoline Derivatives Against Egfr Mutated And Lung Cancer Stem Cells ( Principal Investigator(PI))
  13. 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - AFR (Frontier Science)
    Apoptotic Effects Of Quinazoline Derivatives On Zebrafish Embryos Xenografted With Lung Cancer Stem Cells ( Co-Researcher)
  14. 2014 - 2017, Fundamental Research Grant Scheme (FRGS)
    Antineoplastic Mechanism Of Oxadiazole Derivatives In Hormone-Dependent And -Independent Breast Cancer Cell Lines, And Zebrafish Model ( Principal Investigator(PI))
  15. 2015 - 2017, RU Geran
    In-vitro Aca Metabolism Studies And Analytical Method Development Of Aca And Metabolite(s) In Animal Samples ( Principal Investigator(PI))
  16. 2015 - 2017, Postgraduate Research Grant (PPP) - Research
    Elucidating the modulation of antidiabetic targets by diterpenes from Alpinia pahangensis Ridley ( Principal Investigator(PI))
  17. 2013 - 2016, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness)
    Investigation Of The Apoptotic Mechanism In Colon And Lung Cancer Cell Lines Of Two Potent Cyclic Polyketides: Endiandric Acid A And C ( Principal Investigator(PI))
  18. 2013 - 2016, MOSTI-Science Fund
    Synthesis Of Resveratrol Analogues And Studies On Their Cellular Anticancer Signalling Pathways ( Principal Investigator(PI))
  19. 2014 - 2016, Postgraduate Research Grant (PPP) - Research
    Studies on the cytotoxic effects and the cellular mechanism of selected resveratrol analogues ( Principal Investigator(PI))
  20. 2015 - 2016, Bantuan Kecil Penyelidikan (BKP)
    Antidiabetic Labdane Diterpenes from the Rhizomes of Alpinia pahangensis ( Co-Researcher)
  21. 2013 - 2014, Program Rakan Penyelidikan UM
    Elucidating the Modulation of Antidiabetic Targets by Rare Triterpenoids from Aglaia Malaccensis Pannell ( Principal Investigator(PI))
Private
  1. 2017 - 2023, Private Funding
    Untrageted And Targeted Metabolomics Analysis Of Healthy And Hiv-infected Patient Blood Sample ( Principal Investigator(PI))

CONSULTANCY PROJECT


  • Lipidomics Study of a Local Plant in Cultured Human Liver Cells., Agilent Technologies Sales (Malaysia) Sdn. Bhd., Consultant
    14 Jan 2022 - 13 Jan 2027 (National)

PAPER PRESENTED


INVITED SPEAKER
  1. Phytochemical, antioxidant and antiglycative properties of six herbal plants as potential preventive agents in type 2 diabetes mellitus, The 143rd Annual Meeting of the Pharmaceutical Society of Japan, The Pharmaceutical Society of Japan (International) (25 Mar 2023 - 28 Mar 2023)
  2. Mechanism of antitumour of betulinic acid in leukemia stem cells and zebrafish, Kyushu University Asia Week 2020, Kyushu University, Japan (International) (10 Sep 2020 - 10 Sep 2020)
  3. Development of a carrier using carboxymethylated carrageenan for oral insulin delivery, Faculty of Pharmaceutical Science University of Toyama and Faculty of Pharmacy University of Malaya Collaboration, Faculty of Pharmaceutical Science, University of Toyama, Toyama, Japan. (International) (28 Nov 2019 - 28 Nov 2019)
  4. Mechanism of antitumor of betulonic acid in leukaemia stem cells and zebrafish, The 1st Institute of Medicinal Plant Development-University of Malaya Symposium, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College (International) (21 Jul 2019 - 21 Jul 2019)
EVENT ORGANISER
  1. Scientific and programme book committee, Annual Colloquium on Drug Development from Natural Products, CENAR (National) (12 Aug 2015 - 12 Aug 2015)
  2. From Powder to Pill and Pill to Heal, FOM Research Week, Faculty of Medicine (International) (11 May 2015 - 15 May 2015)
ORAL PRESENTER
  1. Mechanism of antitumor of betulonic acid in leukaemia stem cells and zebrafish, Kyushu University-University of Malaya Pharmacy Symposium , Department of Pharmacy, Faculty of Medicine, University of Malaya (International) (28 Nov 2018 - 28 Nov 2018)
  2. Pytochemicals and potential bioactive compounds from selected Malaysian medicinal plants, Academia Sinica University of Malaya Research Symposium on Life Sciences and Physical Scienc, Academia Sinica, Taiwan (International) (27 Oct 2016 - 27 Oct 2016)
  3. Rational design and biological evaluations of 1,3,4-Oxadiazoline and their derivatives as potential COX-2 selective inhibitors, The International Startup Symposium of cutting-edge organic chemistry in Asia (III), National Tsing Hua University (International) (19 Apr 2014 - 21 Apr 2014)
POSTER PRESENTER
  1. Betulonic acid from Walsura pinnata Hassk (Meliaceae) triggered intrinsic apoptosis in leukaemia stem cells and zebrafish model, International Malaysian French Scientific Conference 2017, University Malaya (International) (18 Dec 2017 - 19 Dec 2017)
  2. Novel alpha-glucosidase inhibitors from Myristica Cinnamomea King, Monash Science Symposium, Monash University (National) (21 Nov 2016 - 23 Nov 2016)
  3. Apoptotic mechanism studies of N-(4-Chlorophenyl)-2-(4-(3,4,5-trimethoxybenzyloxy)benzoyl) hydrazinecarbothioamide on selected breast cancer cell lines, Monash Science Symposium, Monash University (National) (21 Nov 2016 - 23 Nov 2016)
  4. Investigation on the apoptotic mechanism of N-(3,4,5-trimethoxybenzylidine)-4-(3,4,5-trimethoxybenzyloxy) benzohydrazide synthetic compound against colon cancer cell lines, Monash Science Symposium, Monash University (National) (21 Nov 2016 - 23 Nov 2016)
  5. Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line, Annual Colloquium on Drug Development from Natural Products, CENAR (National) (12 Aug 2015 - 12 Aug 2015)
  6. The discovery of new kingianic acids from Endiandra Kingiana with potential anticancer activity, University of Malaya Researchers' Conference (UMRC) 2013, University of Malaya (University) (19 Nov 2013 - 20 Nov 2013)

ACADEMIC/PROF. SERVICES


Evaluation
  1. (2023) Proposal Defence for Masters Students Keith Ng Xin Jie, University, (Internal Assessor)
  2. (2023) Specification Evaluation for Rotary Evaporator, University, (Internal Evaluator)
  3. (2023) Internal Examiner for Masters Candidature Defence of Malamugila Manimaran, University, (Internal Examiner)
  4. (2023) Specification Evaluation for Polarimetry Instrument, University, (Internal Evaluator)
  5. (2023) Internal Examiner for Phd Candidature Defence of Nur Syafiqah Rahim, University, (Internal Examiner)
  6. (2021) Mosti Tech Development Grant Evaluator, National, (External Evaluator)
  7. (2021) Malaysian Toray Science Foundation, University, (Internal Evaluator)
  8. (2021) Postgraduate Programme Assessor, University, (Internal Assessor)
  9. (2020) Internal Examiner for PhD candidate Lim See Khai (MHA150018) with the thesis title of Rational discovery of novel NS3 Enzyme inhibitors for genotype3 hepatitis C virus , (Internal Examiner)
  10. (2020) Reviewed a manuscript entitled "TLE1 improves insulin sensitivity through insulin signalling pathway" for Natural Product Communications journal (NPX-19-0177)., (Reviewer)
  11. (2019) Reviewed a manuscript titled 20(S)-Ginsenoside Rh2 induced paraptosis-like death by impairing VCP-mediated protein degradation in SH-SY5Y cells in Phytomedicine journal , (Reviewer)
  12. (2018) Internal examiner for PhD thesis titled Evaluation of selected compounds as inhibitors of cholinesterase and amyloid beta aggregation. , (Internal Examiner)
  13. (2018) Examiner for Masters proposal defence of Ms. Amanda Anne Lavinya with a thesis title of Examination of circulating proteins and messenger RNA in blood plasma of HIV infected patients with chronic kidney disease, (Internal Examiner)
  14. (2018) Examiner for PhD candidature defence of Ms. Theeba Anasamy with a thesis title of In vitro and in vivo anticancer properties of tribenzyltin carboxylates., (Internal Examiner)
  15. (2018) Internal Examiner for PhD thesis titled Rational Discovery of Novels NS3 Enzyme Inhibitors for Genotype 3 Hepatitis C Virus , (Internal Examiner)
  16. (2018) Reviewer for an article titled "20(S)-Ginsenoside Rh2 induced paraptosis-like death by impairing VCP-mediated protein degradation in SH-SY5Y cells" in Phytomedicine journal. , (Reviewer)
  17. (2017) Reviewed a manuscript titled ' Sulfanilic acid-modified chitosan mini-spheres and their application for lysozyme purification from egg white' for journal of Reactive and Functional Polymers., (Reviewer)
  18. (2017) Technical committee for tender on fumehoods for Department of Chemistry, Faculty of Science, University of Malaya., (Advisory Committee)
  19. (2017) Candidature defence for PhD student, Ser Devi A/P Sukumaran (MHA 130071) titled "Evaluation of selected compounds as inhibitors of cholinesterases and amyloid-b aggregation"., (Internal Examiner)
  20. (2017) PhD proposal defence titled 'Development and Evaluation of Lipid-based nanoparticles to deliver 1 S-1 -acetoxychavicol acetate (ACA) as a therapeutic agent in cancer therapy', (Internal Examiner)
  21. (2017) Masters degree proposal defence 'The Effects of Natural Cytotoxic Compound, Pinnatane A Extracted from Walsura pinnata Hassk. Bark on the Apoptotic Signalling Pathways in Tumour Cell Lines.', (Internal Examiner)
  22. (2016) Candidature defence for PhD student Cheah Hoay Yan from Department of Pharmacology, University of Malaya titled evaluation of near-infrared activable poly-L-glutamic acid-phthalocyanine conjugated in breast cancer cells by photodynamic therapy and safety of polymer nanocarriers on cardiovascular system., (Internal Examiner)
  23. (2016) Review a manuscript titled 'In vitro glucosidase inhibitory activity of isolated fractions from water extract of dark tea.' in BMC Complimentary and Alternative Medicine journal., (Reviewer)
  24. (2015) Examiner for seminar before PhD thesis submission for PhD candidate, Bahareh Sabeti with thesis title "Development and characterization of liposomal doxorubicin HCl with application of palm oil", (Internal Examiner)
  25. (2015) Review an article entitled "Simultaneous HPTLC Analysis of Cucurbitacin B, D and E; Betulinic acid; Picroside 1, 2 and Apocynin in Bioactivity Guided Anticancer Enriched Fraction of Picrorhiza kurroa" submitted to journal of Drug Design Development and Therapy., (Reviewer)
  26. (2015) Review an article entitled "Aloe emodin enhances tamoxifen anti-proliferative effect on ERα-positive breast cancer cells, MCF-7 through downregulation of MEK1 and MEK2" submitted to JUMMEC journal. , (Reviewer)
  27. (2014) Molecular modeling of muscarinic acetylcholine receptors , (Internal Examiner)
  28. (2014) One of the members in the editorial board of the Journal of Pharmaceutics and Pharmacology, (Editor)
Contribution to external organisation
  1. (2022) UM Health Task Force, University, (Technical Advisor)
  2. (2021) Internal Auditor 22/2021, University, (Auditor)
  3. (2020) Evaluation committee for purchase of freeze drier for the Faculty of Pharmacy, Faculty of Pharmacy
  4. (2018) Technical committee for evaluation of UV/Visible Spectrometer tender for Faculty of Pharmacy , Faculty of Pharmacy, University of Malaya
  5. (2017) Kyushu University - University Malaya Collaborative Program, Kyushu University, Japan, International
  6. (2017) Technical committee member for fumehood tender, Department of Chemistry, Faculty of Science, University of Malaya

SUPERVISION


Postgraduate Student
PhD/ Doctoral
  1. (2023) Investigation of the lipid-lowering effect of Alternanthera sesillis (red) using human hepatoma HepG2 cells from the perspective of lipidomics, HWONG CHIA SHING
  2. (2023) Anticancer Potential of Analogues Bearing 2-(quinazolin-4-ylamino) Benzamide as Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines, RASHIDI BIN DZUL KEFLEE
  3. (2023) The Role of D-Amino Acids in Modulating Immune Activation and Ageing in People Living with HIV, YAP SIEW HWEI
  4. (2020) The Role of Metabolomics in Immune Recovery and Premature Aging in Treated HIV., YAP SIEW HWEI
  5. (2020) SYNTHESIS OF NEW ANILINOQUINAZOLINE DERIVATIVES AS ANTICANCER AGENTS: ANTIPROLIFERATIVE ACTIVITY, MOLECULAR DOCKING AND MOLECULAR DYNAMICS STUDIES, MUHAMMAD KUMAYL BIN ABDUL WAHAB
  6. (2020) SYNTHESIS AND ANTITUMOR ACTIVITY OF QUINAZOLINONE DERIVATIVES, FATIN NUR ELYANA BINTI MOHD SIDEK
  7. (2020) FRACTIONATION OF ALTERNANTHERA SESILLIS (RED) EXTRACT AND ITS HYPOLIPIDAEMIC EFFECT ON HUMAN HEPATOMA HEPG2 CELLS, HWONG CHIA SHING
  8. (2020) SYNTHESIS OF NEW ANILINOQUINAZOLINE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: ANTIPROLIFERATIVE ACTIVITY, MOLECULAR DOCKING AND MOLECULAR DYNAMICS STUDIES, MUHAMMAD KUMAYL BIN ABDUL WAHAB
  9. (2018) ORAL INSULIN DELIVERY SYSTEM BASED ON CHITOSAN-COMPLEXED CARBOXYMETHYLATED IOTA-CARRAGEENAN NANOPARTICLES, PRATYUSA SAHOO
  10. (2012) Oral insulin delivery system based on chitosan-modified carboxymethylated iota-carrageenan nanoparticles, Pratyusa Sahoo
Master
  1. (2023) Optimization of Polymyxin B Combinations with Chloramphenicol Derivatives in Combatting Multidrug Resistant (MDR) Klebsiella pneumoniae., NURULAIN BINTI IDRIS
  2. (2023) Serum and salivary biomarkers of oxidative and nitrative stress and susceptibility to genetic damage in oral leukoplakia, Yoon Xuan Liew
  3. (2023) INVESTIGATION ON THE EFFECTS OF HYPOXIA-MIMICKING AGENTS IN CANCER PROGRESSION AND OXIDATIVE STRESS OF HEPATOCELLULAR CARCINOMA, JUNE XIN NI WONG
  4. (2023) INVESTIGATION INTO THE EFFECTS OF HYPOXIA-INDUCIBLE FACTOR PROLYL-HYDROXYLASE INHIBITORS ON HUMAN LUNG CANCER PROGRESSION, KHALISHAH YUSRI
  5. (2023) Effects of Quinazoline Derivatives on Non Small Cell Lung Cancer Xenografted in Zebrafish Embryos, ROSE AMALINA BINTI RUSLAN
  6. (2022) Phytochemical, Antioxidant and Antiglycative Properties of Six Herbal Plants as Potential Preventive Agents in Type 2 Diabetes Mellitus, WONG CHEN YUAN
  7. (2020) Investigation of Phytochemical, Antioxidant and Antidiabetic Properties of Selected Herbal Plants., WONG CHEN YUAN
  8. (2020) An Investigation on the effects of Hypoxia-mimcking agents in cancer progression and oxidative stress of hepatocellular carcinoma, June Xin Ni Wong
  9. (2020) AN INVESTIGATION INTO THE EFFECTS OF CLINICAL HIF PROLYL-HYDROXYLASE INHIBITORS ON HUMAN LUNG CANCER PROGRESSION, KHALISHAH YUSRI
  10. (2019) SCREENING AND APOPTOTIC MECHANISM STUDIES OF ANALOGUES CONTAINING (3,4,5-TRIMETHOXYBENZYLOXY)PHENYL MOIETY ON SELECTED BREAST CANCER CELL LINES, STEPHANIE BERNARDINE
  11. (2019) Effects of Quinazoline Derivatives on Non Small Cell Lung Cancer Xenografted in Zebrafish Embryos, ROSE AMALINA BINTI RUSLAN
  12. (2019) CYTOTOXICITY SCREENING AND EVALUATION OF APOPTOTIC MECHANISM OF ANALOGUES CONTAINING (3,4,5-TRIMETHOXYBENYLOXY) PHENYL MOIETY ON SELECTED BREAST CANCER CELL LINES, STEPHANIE BERNARDINE
  13. (2018) SCREENING AND INVESTIGATION OF APOPTOSIS OF SUBSTITUENTS BEARING A (3,4,5-TRIMETHOXYBENZYLOXY) PHENYL MOIETY ON SELECTED COLORECTAL CANCER CELL LINES., ZACHARIAH CHAN CHEE KEN
  14. (2017) THE ROLE OF HUMAN HERPESVIRUS (HHV) INFECTIONS AND PERSISTENT IMMUNE ACTIVATION IN ANTIRETROVIRAL THERAPY-TREATED HIV-INFECTED INDIVIDUALS, YAP SIEW HWEI
  15. (2016) INVESTIGATION OF THE APOPTOTIC EFFECTS OF CYCLOART-24-ENE-3B,26-DIOL FROM Aglaia exima ON SELECTED BREAST CANCER CELL LINES., DEEPA A/P JEEVANANTHAN
  16. (2015) The Role Of Human Herpes Virus (HHV) Infections And Persistent Immune Activation In ART Treated HIV-infected Individuals, Yap Siew Hwei
  17. (2014) Investigation on the apoptotic mechanism of pure compounds isolated from Endiandra Kingiana Gamble against colon and lung cancer cell lines, Zachariah Chan Chee Kee
  18. (2012) Investigation of the apoptotic effects of bioactive compounds from Aglaia exima on selected cancer cell lines, Deepa a/p Jeevananthan
Under Graduate Students
  1. (2014) Stability studies on oral insulin nanoparticle complexation between chitosan and carrageenan
  2. (2014) Screening and docking of a series of resveratrol analogues against estrogen receptor binding
  3. (2014) Kinetic studies of -glucosidase enzyme inhibitor activity of pure compounds from Myristica annamomea plant
  4. (2014) Kinetic studies of -amylase enzyme inhibitor activity of pure compounds from Myristica annamomea plant
  5. (2013) Studies on the oral insulin nanoparticle complexation between chitosan and carrageenan
  6. (2013) Screening of Meliaceae plant extracts against α-glucosidase enzyme inhibitor activity
  7. (2013) Screening of Meliaceae plant extracts against α-amylase enzyme inhibitor activity
  8. (2013) Molecular modelling and pharmacophore identification for a series of chalcones with lipoxygenase inhibitory activity

TEACHING


Master
  1. (2023) OQB7001 - Methods in Drug Discovery and Pre-Clinical Drug Development
  2. (2021) OVA8001 - Research Methodology
Bachelor
  1. (2023) OIA2006 - Chromatography, Electrochemistry and Radiochemistry
  2. (2023) OIA2002 - Pharmaceutical Analysis
  3. (2023) OIA3025 - Pharmaceutical Biotechnology and Personalised Medicine
  4. (2023) OIA1012 - Pharmaceutical Organic Chemistry
  5. (2021) OIA1003 - Biochemistry
  6. (2021) OIA2002 - Pharmaceutical Analysis
  7. (2021) OIA1012 - Pharmaceutical Organic Chemistry
  8. (2017) MIB2006 - Chromatography, Electrochemistry and Radiochemistry
  9. (2017) MWEF3110 - Speciality Pharmaceutical Dosage Form Design
  10. (2016) MIB2002 - Pharmaceutical Analysis
  11. (2016) MWEF3106 - Pharmaceutical Product Development
  12. (2014) MWEF1102 - Pharmaceutical Organic Chemistry
  13. (2014) MWEF2102 - Pharmaceutical Analysis
  14. (2014) MWEF2106 - Chromatography, Electrochemistry & Radiochemistry
  15. (2013) MWEF2102 - Pharmaceutical Analysis
  16. (2013) MWEF2106 - Chromatography, Electrochemistry & Radiochemistry
  17. (2012) MWEF3106 - Pharmaceutical Product Development

SOCIAL RESPONSIBILITY ACTIVITIES


  • Jalinan Masyarakat Rumah Titian Kaseh, Taman Tasik Titiwangsa, Kuala Lumpur. Malaysia., (15 May 2016 - 15 May 2016)

COURSE ATTENDED


Internal / External Course
CONFERENCE
  1. THE 143RD ANNUAL MEETING OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Hokkaido University, Sapporo (25 Mar 2023 - 29 Mar 2023)