Wenn-Chyau Lee received his BSc (Hons) degree in Biomedical Sciences from Universiti Malaya, Malaysia in 2011, and graduated with his PhD in Medical Sciences from Universiti Malaya in 2014. Subsequently, he joined Singapore Immunology Network (SIgN, A*STAR) as a research fellow. He was appointed as SIgN fellow (young investigator) in 2018. He joined A*STAR ID Labs as an investigator in 2021. Subsequently, he joined the Department of Parasitology, Faculty of Medicine, Universiti Malaya as a senior lecturer. Currently, he is also an adjunct investigator of A*STAR ID Labs, Singapore.

As a parasitologist, he has involved in studies encompassing several medically important parasites. His main research interest revolves around the immuno-pathobiology of malaria. He has been investigating and deciphering the roles of rosetting (a phenomenon where a Plasmodium-infected red blood cell is stably adhered to uninfected red blood cells, forming a flower-like structure called ‘rosette’) in the pathogenesis of malaria. Besides, he is exploring the potential of applying different biocontrol strategies to eliminate vector-borne diseases. He has worked as a research fieldworker in different places. As different laboratory settings are equipped differently, he enjoys adapting and improvising facilities available in the field sites to conduct experiments, as well as coordinating the insectarium and Arthropod Containment Level 2(ACL2) facility in the Faculty of Medicine, Universiti Malaya. To date, he has published (as first/ corresponding author) in reputable journals such as Blood, Frontiers in Immunology, Frontiers in Cellular and Infection Microbiology, eLife, EBioMedicine, Entomologia Generalis, and Trends in Parasitology. Apart from reviewing manuscripts for various journals, as well as evaluating grant proposals for local and overseas funders, he is also an associate editor of Frontiers in Microbiology and one of the editorial board members for the journal Decoding Infection and Transmission. 

He has involved in various teaching activities for students from different programs in Universiti Malaya, such as the Bachelor of Medicine, Bachelor of Surgery (MBBS), Bachelor of Biomedical Science, Master of Pathology (MPATH), and Master of Medical Parasitology and Entomology, as well as the students from overseas institutes. He is also the coordinator and instructor of the annual microscopy training (Kuala Lumpur station) for the Diploma in Tropical Medicine and Hygiene (DTM&H) co-organized by the University of Glasgow and Universiti Malaya. He served as a moderator in "Implementation Research (WPR-facilitated)", a Massive Open Online Course (MOOC) by RTC-TDR-WHO in 2025.

He has been a member of the Research Management Unit (RMU), Faculty of Medicine, Universiti Malaya since 2022. He serves as the coordinator of the Grant Empowerment Section (GROW) under the Center for Core Research Excellence (TERAS), Universiti Malaya. He is also a member of the Malaysian Society for Biochemistry and Molecular Biology (MSBMB), and the Malaysian Society of Parasitology and Tropical Medicine (MSPTM).