ARTICLE IN ACADEMIC JOURNALS
        
        | NO | DETAILS OF ARTICLE IN ACADEMIC JOURNALS | 
|---|---|
| 1. | 
                                    Preparation and Preliminary Structure-Activity Relationship Studies of Schwarzinicine A Analogs as Vasorelaxant Agents 
                                    2024
                                 Author(s) : Low Yun Yee Source : JOURNAL OF NATURAL PRODUCTS DOI : 10.1021/acs.jnatprod.3c00707 | 
| 2. | 
                                    Quinoline, Indole, and Isogranatanine Alkaloids from Malayan <i>Leuconotis eugeniifolia</i> 
                                    2024
                                 Source : JOURNAL OF NATURAL PRODUCTS DOI : 10.1021/acs.jnatprod.3c00960 | 
| 3. | 
                                    Eugeniifoline, a Pentacyclic Indole Alkaloid from Leuconotis eugeniifolia, and Configurational Revision of Synthetic Eugeniifoline Isolated from a Diversity-Enhanced Extract 
                                    2023
                                 Source : Journal of natural products DOI : 10.1021/acs.jnatprod.2c00731 | 
| 4. | 
                                    Chippiine, iboga, cleavamine, vobasine, and cytotoxic bisindole alkaloids from <i>Tabernaemontana polyneura</i> 
                                    2023
                                 Source : TETRAHEDRON DOI : 10.1016/j.tet.2023.133706 | 
| 5. | 
                                    Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis 
                                    2023
                                 Author(s) : Low Yun Yee Source : Nature DOI : 10.1038/s41586-023-06716-y | 
| 6. | 
                                    Chippiine, iboga, cleavamine, vobasine, and cytotoxic bisindole alkaloids from Tabernaemontana polyneura 
                                    2023
                                 Source : Tetrahedron DOI : 10.1016/j.tet.2023.133706 | 
| 7. | 
                                    Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis 
                                    2023
                                 Author(s) : Low Yun Yee Source : NATURE DOI : 10.1038/s41586-023-06716-y | 
| 8. | 
                                    Polyneurines A−H, iboga alkaloids from Tabernaemontana polyneura 
                                    2023
                                 Source : Phytochemistry DOI : 10.1016/j.phytochem.2023.113587 | 
| 9. | 
                                    Polyneurines A-H, iboga alkaloids from Tabernaemontana polyneura 
                                    2023
                                 Source : PHYTOCHEMISTRY DOI : 10.1016/j.phytochem.2023.113587 | 
| 10. | 
                                    Eugeniifoline, a Pentacyclic Indole Alkaloid from Leuconotis eugeniifolia, and Configurational Revision of Synthetic Eugeniifoline Isolated from a Diversity-Enhanced Extract 
                                    2023
                                 Source : JOURNAL OF NATURAL PRODUCTS DOI : 10.1021/acs.jnatprod.2c00731 | 
| 11. | 
                                    Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus 
                                    2022
                                 Author(s) : Yong Kien Thai, Low Yun Yee Source : Phytochemistry DOI : 10.1016/j.phytochem.2021.112988 | 
| 12. | 
                                    Arboduridine, a hexacyclic caged monoterpenoid indole incorporating cyclohexane, piperidine, and bridged-fused pyrrolidine-tetrahydrofuran moieties 
                                    2022
                                 Author(s) : Lim Siew Huah, Low Yun Yee Source : Tetrahedron Letters DOI : 10.1016/j.tetlet.2022.153836 | 
| 13. | 
                                    Vobasine, vincamine, voaphylline, tacaman, and iboga alkaloids from Tabernaemontana corymbosa 
                                    2022
                                 Author(s) : Lim Siew Huah, Low Yun Yee Source : Phytochemistry DOI : 10.1016/j.phytochem.2022.113384 | 
| 14. | 
                                    Antiproliferative and Microtubule-stabilizing Activities of Two Iboga-vobasine Bisindoles Alkaloids from Tabernaemontana corymbosa in Colorectal Adenocarcinoma HT-29 Cells 
                                    2022
                                 Source : Planta Medica DOI : 10.1055/a-1755-5605 | 
| 15. | 
                                    Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus 
                                    2021
                                 Author(s) : Yong Kien Thai, Low Yun Yee Source : JOURNAL OF NATURAL PRODUCTS DOI : 10.1021/acs.jnatprod.1c00374 | 
| 16. | 
                                    A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis 
                                    2021
                                 Author(s) : Low Yun Yee Source : PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA DOI : 10.1073/pnas.2102949118 | 
| 17. | 
                                    Concise synthesis of the vasorelaxant alkaloids schwarzinicines A and B 
                                    2021
                                 Author(s) : Low Yun Yee Source : Natural Product Research DOI : 10.1080/14786419.2021.1903005 | 
| 18. | 
                                    The bisindole alkaloids Angustilongines M and A from Alstonia penangiana induce mitochondrial apoptosis and G0/G1 cell cycle arrest in HT-29 cells through promotion of tubulin polymerization 
                                    2021
                                 Source : JOURNAL OF NATURAL PRODUCTS | 
| 19. | 
                                    Arbolodinines A-C, biologically-active aspidofractinine-aspidofractinine, aspidofractinine-strychnan, and kopsine-strychnan bisindole alkaloids from Kopsia arborea 
                                    2021
                                 Source : TETRAHEDRON DOI : 10.1016/j.tet.2020.131802 | 
| 20. | 
                                    A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis 
                                    2021
                                 Author(s) : Low Yun Yee Source : PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA DOI : 10.1073/pnas.2102949118|1of12 | 
| 21. | 
                                    Arbolodinines A-C, biologically-active aspidofractinine-aspidofractinine, aspidofractinine-strychnan, and kopsine-strychnan bisindole alkaloids from Kopsia arborea 
                                    2021
                                 Source : TETRAHEDRON DOI : 10.1016/j.tet.2020.131802 | 
| 22. | 
                                    The Bisindole Alkaloids Angustilongines M and A from Alstonia penangiana Induce Mitochondrial Apoptosis and G0/G1 Cell Cycle Arrest in HT-29 Cells through Promotion of Tubulin Polymerization 
                                    2021
                                 Source : JOURNAL OF NATURAL PRODUCTS DOI : 10.1021/acs.jnatprod.1c00013 | 
| 23. | 
                                    Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii 
                                    2020
                                 Source : JOURNAL OF NATURAL PRODUCTS | 
| 24. | 
                                    Asperginols A and B, Diterpene Pyrones, from an Aspergillus sp. and the Structure Revision of Previously Reported Analogues 
                                    2020
                                 Author(s) : Low Yun Yee, Mohammed Abdullah Mahdi Alshawsh Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.0c00618 | 
| 25. | 
                                    Evaluation of DNA Binding and Topoisomerase I Inhibitory Activities of 16      Decarbomethoxydihydrovoacamine from Tabernaemontana corymbosa 
                                    2020
                                 Author(s) : Low Yun Yee Source : Chemistry Select DOI : 10.1002/slct.202004153 | 
| 26. | 
                                    Schwarzinicines A   G, 1,4-Diarylbutanoid   Phenethylamine Conjugates from the Leaves of Ficus schwarzii 
                                    2020
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.9b01160 | 
| 27. | 
                                    Lycopodium alkaloids: Lycoplatyrine A, an unusual lycodine-   piperidine adduct from Lycopodium platyrhizoma and the absolute configurations of Lycoplanine D and Lycogladine H 
                                    2019
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.8b00754 | 
| 28. | 
                                    Macroline-   sarpagine bisindole alkaloids with antiproliferative activity from Alstonia penangiana 
                                    2019
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.9b00712 | 
| 29. | 
                                    Reactions of Anodically Generated Methoxystilbene Cation Radicals: The Influence of Ortho-   Substituted Vinyl and Formyl Groups 
                                    2019
                                 Author(s) : Low Yun Yee Source : Journal of Organic Chemistry DOI : 10.1021/acs.joc.9b00939 | 
| 30. | 
                                    Diphenethylpiperidine alkaloids with tracheal smooth muscle relaxation activity from Hippobroma longiflora (L.) G. Don 
                                    2019
                                 Author(s) : Low Yun Yee Source : Phytochemistry Letters DOI : 10.1016/j.phytol.2019.01.035 | 
| 31. | 
                                    Alstobrogaline, an unusual pentacyclic monoterpenoid indole alkaloid with aldimine and aldimine-N-oxide moieties from Alstonia scholaris 
                                    2019
                                 Author(s) : Low Yun Yee Source : Tetrahedron Letters DOI : 10.1016/j.tetlet.2019.02.018 | 
| 32. | 
                                    Conolodinines A-D, Aspidosperma-Aspidosperma Bisindole Alkaloids with Anti-proliferative Activity from Tabernaemontana corymbosa 
                                    2019
                                 Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.8b00919 | 
| 33. | 
                                    A Cytotoxic Indole Characterized by Incorporation of a Unique Carbon-   Nitrogen Skeleton and Two Pentacyclic Corynanthean Alkaloids Incorporating a Substituted Tetrahydrofuranone Ring from Kopsia arborea 
                                    2019
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.9b00255 | 
| 34. | 
                                    Ajmaline, Oxindole, and Cytotoxic Macroline   Akuammiline Bisindole Alkaloids from Alstonia penangiana 
                                    2018
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.8b00170 | 
| 35. | 
                                    Reactivity of Anodically Generated 4-Methoxystilbene Cation Radicals: The Influence of Ortho-Substituted Hydroxymethyl, Aminomethyl, and Carboxylic Acid Groups 
                                    2018
                                 Author(s) : Low Yun Yee Source : Journal of Organic Chemistry DOI : 10.1021/acs.joc.8b02360 | 
| 36. | 
                                    Alstoscholactine and Alstolaxepine, Monoterpenoid Indole Alkaloids with   -Lactone-Bridged Cycloheptane and Oxepane Moieties from Alstonia scholaris 
                                    2018
                                 Author(s) : Low Yun Yee Source : Organic Letters DOI : 10.1021/acs.orglett.8b03592 | 
| 37. | 
                                    Unusual phenethylamine-   containing alkaloids from Elaeocarpus tectorius 
                                    2018
                                 Author(s) : Low Yun Yee Source : Phytochemistry DOI : 10.1016/j.phytochem.2017.12.003 | 
| 38. | 
                                    A Bis-benzopyrroloisoquinoline Alkaloid Incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine Alkaloid with Cytotoxic Activity from Ficus fistulosa var. tengerensis. 
                                    2017
                                 Author(s) : Low Yun Yee Source : Journal of Natural Product DOI : 10.1021/acs.jnatprod.7b00500 | 
| 39. | 
                                    Biosynthetic Enantiodivergence in the Eburnane Alkaloids from Kopsia. 
                                    2017
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.7b00621 | 
| 40. | 
                                    Electrochemically Mediated Oxidative Transformations of Substituted 4-Methoxystilbenes: Effect of Ortho-Substituted Nucleophilic Groups 
                                    2017
                                 Author(s) : Low Yun Yee Source : Journal of Organic Chemistry DOI : 10.1021/acs.joc.7b00753 | 
| 41. | 
                                    Vobatensines A-   F, Cytotoxic Iboga-   Vobasine Bisindoles from Tabernaemontana corymbosa 
                                    2016
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.5b01117 | 
| 42. | 
                                    Arborisidine and Arbornamine, Two Monoterpenoid Indole  Alkaloids with New Polycyclic Carbon-Nitrogen Skeletons  Derived From a Common Pericine Precursor 
                                    2016
                                 Author(s) : Low Yun Yee Source : Organic Letters | 
| 43. | 
                                    Fistulopsines A and B Antiproliferative Septicine- Type Alkaloids from Ficus fistulosa 
                                    2016
                                 Author(s) : Low Yun Yee Source : Phytochemistry Letters | 
| 44. | 
                                    Ibogan, Aspidosperman, Vincamine, and Bisindole Alkaloids from a Malayan Tabernaemontana corymbosa: Iboga Alkaloids with C-20   Substitution 
                                    2016
                                 Author(s) : Low Yun Yee, Noel Francis Thomas Source : Journal of Natural Products | 
| 45. | 
                                    A Hexacyclic, Iboga-Derived Monoterpenoid Indole with a Contracted Tetrahydroazepine C‑Ring and Incorporation of an Isoxazolidine Moiety, a Seco-Corynanthean, an AspidospermaAspidosperma Bisindole with Anticancer Properties, and the Absolute Configuration of the Pyridopyrimidine Indole Alkaloid, Vernavosine. 
                                    2016
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.6b00674 | 
| 46. | 
                                    Aspidofractinine and Eburnane Alkaloids from a North  Borneo Kopsia. Ring-Contracted, Additional Ring- Fused, and Paucidactine-Type Aspidofractinine  Alkaloids from K. pauciflora 
                                    2016
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products DOI : 10.1021/acs.jnatprod.5b00992 | 
| 47. | 
                                    Hispidacine, an unusual 8,40-oxyneolignan- alkaloid  with vasorelaxant activity, and  hispiloscine, an  antiproliferative  phenanthroindolizidine alkaloid,  from Ficus  hispida Linn. 
                                    2015
                                 Author(s) : Low Yun Yee Source : Phytochemistry DOI : 10.1016/j.phytochem.2014.10.032 | 
| 48. | 
                                    Biologically active vallesamine, strychnan, and   rhazinilam alkaloids from Alstonia:  Pneumatophorine,  a nor-   secovallesamine with  unusual incorporation  of  a 3-   ethylpyridine  moiety 
                                    2015
                                 Author(s) : Low Yun Yee Source : Phytochemistry | 
| 49. | 
                                    Ibogan, Tacaman, and Cytotoxic Bisindole  Alkaloids  from Tabernaemontana. Cononusine, an  Iboga Alkaloid  with Unusual Incorporation of a  Pyrrolidone Moiety 
                                    2015
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 50. | 
                                    Arboridinine, a Pentacyclic Indole Alkaloid with a  New Cage Carbon-   Nitrogen Skeleton Derived from a  Pericine Precursor 
                                    2015
                                 Author(s) : Low Yun Yee Source : Organic Letters DOI : 10.1021/acs.orglett.5b01757 | 
| 51. | 
                                    Transformations of Ferric Chloride-Generated    Stilbene Cation Radicals. The Effect of   Aromatic  Substitution and a Comparison with   Anodic Oxidation 
                                    2015
                                 Author(s) : Low Yun Yee Source : Chemistry - An Asian Journal | 
| 52. | 
                                    Cytotoxic Vobasine, Tacaman, and  Corynanthe- Tryptamine Bisindole Alkaloids from   Tabernaemontana and Structure Revision of  Tronoharine. 
                                    2014
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 53. | 
                                    Biomimetic Oxidative Dimerization of Anodically    Generated Stilbene Radical Cations: Effect of   Aromatic Substitution on Product Distribution   and Reaction Pathways 
                                    2014
                                 Author(s) : Low Yun Yee Source : Journal of Organic Chemistry | 
| 54. | 
                                    Macroline, akuammiline, sarpagine, and ajmaline    alkaloids from Alstonia macrophylla. 
                                    2014
                                 Author(s) : Low Yun Yee Source : Phytochemistry | 
| 55. | 
                                    Criofolinine and Vernavosine, New Pentacyclic Indole  Alkaloids Incorporating Pyrroloazepine and  Pyridopyrimidine Moieties Derived From a Common  Yohimbine Precursor. 
                                    2014
                                 Author(s) : Low Yun Yee Source : Organic Letters | 
| 56. | 
                                    Andransinine: An Unusual Case of Spontaneous      Resolution  in an Indole Alkaloid Derivative 
                                    2014
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 57. | 
                                    Corynanthean, eburnan, secoleuconoxine, and   pauciflorine alkaloids from Kopsia pauciflora 
                                    2014
                                 Author(s) : Low Yun Yee Source : Phytochemistry | 
| 58. | 
                                    Transformations of the 2,7-Seco Aspidosperma     Alkaloid  Leuconolam, Structure Revision of epi-    Leuconolam, and  Partial Syntheses of Leuconoxine     and Leuconodines A and  F 
                                    2014
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 59. | 
                                    Oxidized Derivatives of Macroline, Sarpagine, and   Pleiocarpamine Alkaloids from Alstonia  angustifolia 
                                    2014
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 60. | 
                                    Lumusidines A-D and villalstonidine F, macroline-    macroline and macroline-pleiocarpamine bisindole     alkaloids from Alstonia macrophylla. 
                                    2013
                                 Author(s) : Low Yun Yee Source : Phytochemistry | 
| 61. | 
                                    Voatinggine and tabertinggine, pentacyclic indole     alkaloids derived from an iboga precursor via a    common cleavamine-type intermediate. 
                                    2013
                                 Author(s) : Low Yun Yee Source : Organic Letters | 
| 62. | 
                                    Rhazinilam-leuconolam-leuconoxine alkaloids from   Leuconotis griffithii 
                                    2013
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 63. | 
                                    Perhentidines A-C: macroline-macroline bisindoles    from  Alstonia and the absolute configuration of    perhentinine  and macralstonine 
                                    2012
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 64. | 
                                    Grandilodines A-C, biologically active indole     alkaloids  from Kopsia grandifolia. 
                                    2011
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 65. | 
                                    Angustilobine and andranginine type indole   alkaloids  and an uleine-secovallesamine  bisindole  alkaloid from  Alstonia angustiloba. 
                                    2011
                                 Author(s) : Low Yun Yee Source : Phytochemistry | 
| 66. | 
                                    Lumutinines A-D, linearly fused macroline-  macroline and macroline-sapargine bisindole from   Alstonia macrophylla. 
                                    2011
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 67. | 
                                    Aspidospermatan-spidospermatan and eburnane-  sarpagine bisindole alkaloids from Leuconotis. 
                                    2010
                                 Author(s) : Low Yun Yee Source : Phytochemistry | 
| 68. | 
                                    Structure, biological activity, and a biomimetic    partial synthesis of the lirofolines, novel   pentacylic  indole alkaloids from  Tabernaemontana. 
                                    2010
                                 Author(s) : Low Yun Yee Source : Tetrahedron  Letters | 
| 69. | 
                                    Strychnan and secoangustilobine A type alkaloids    from  Alstonia spatulata. Revision of the C-20    configuration  of scholaricine. 
                                    2010
                                 Author(s) : Low Yun Yee Source : Journal of Natural Products | 
| 70. | 
                                    Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis. 
                                    2009
                                 Author(s) : Low Yun Yee Source : JOURNAL OF NATURAL PRODUCTS DOI : 10.1021/np900576b | 
| 71. | 
                                    Mersiphyllines A and B from Kopsia. Determination of  relative configuration at a quaternary center via  formation of an alkaloid-borane complex. 
                                    2009
                                 Author(s) : Low Yun Yee Source : Tetrahedron DOI : 10.1016/j.tet.2009.06.079 | 
| 72. | 
                                    Kopsine and danuphylline alkaloids from Kopsia.    Biomimetic partial synthesis of danuphylline B. 
                                    2008
                                 Author(s) : Low Yun Yee Source : Helvetica Chimica Acta DOI : 10.1002/hlca.200890169 | 
| 73. | 
                                    Biomimetic oxidative transformations of pericine: partial synthesis of apparicine and valparicine, a new pentacyclic indole alkaloid from Kopsia. 
                                    2006
                                 Author(s) : Low Yun Yee Source : Tetrahedron Letters DOI : 10.1016/j.tetlet.2006.05.095 | 
		RESEARCH PROJECT
	
	| GRANT | PROGRESS | STATUS | 
|---|---|---|
| Alkaloid Chemosystematics As An Efficient Tool For Identifying Plants Belonging To The Pandanaceae Family (benstonea, Pandanus, Or Freycinetia) Researcher(s) : Dr. Yong Kien Thai, Dr. Lim Siew Huah, Lim Kuan Hon |  | on going | 
| Reactivity Of Anodically Generated Stilbene Cation Radicals: The Effect Of Ortho Substitution By Hydroxymethyl, Aminomethyl, And Carboxylic Acid Groups Researcher(s) : Dr. Lim Siew Huah, Prof. Dr. Kam Toh Seok |  | end | 
| Electrochemically-mediated Oxidative Transformations Of Substituted Stilbenes - The Effect Of Ortho-substitution On The Nature And Distribution Of Products And Reaction Pathways |  | end | 
| Chemical Investigation Of Secondary Metabolites From Two Selected Highland Species (lycopodium And Tabernaemontana) Researcher(s) : Dr. Yong Kien Thai |  | end | 
| Secondary Metabolites from the families, Lycopodiaceae and Apocynaceae Researcher(s) : Dr. Yong Kien Thai, Lim Kuan Hon |  | end | 
		RESEARCH COLLABORATOR
	
	| GRANT | PROGRESS | STATUS | 
|---|---|---|
| Sustainable Synthesis Of The Cytotoxic Indole Alkaloid Valparicine And Investigation Of The Scope And Mechanism Of Antiproliferative Activity |  | end | 
| Electrochemically-mediated Oxidative Transformations Of Substituted Stilbenes - The Effect Of Ortho-substitution On The Nature And Distribution Of Products And Reaction Pathways |  | end | 
