UMEXPERT - DR. LEONG SZE WEI

Publication
Research

ARTICLE IN ACADEMIC JOURNALS

NO	DETAILS OF ARTICLE IN ACADEMIC JOURNALS
1.	Homoharringtonine promotes non-small-cell lung cancer cell death via modulating HIF-1α/ERβ/E2F1 feedforward loop 2024 Author(s) : Leong Sze Wei Source : JOURNAL OF PHARMACY AND PHARMACOLOGY DOI : 10.1093/jpp/rgae110
2.	A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer 2024 Author(s) : Leong Sze Wei Source : FUTURE MEDICINAL CHEMISTRY DOI : 10.1080/17568919.2024.2363668
3.	Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro <i>p</i>LDH and in vivo zebrafish toxicity assessment 2024 Author(s) : Lau Yee Ling, Leong Sze Wei Source : HELIYON DOI : 10.1016/j.heliyon.2024.e27462
4.	A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms 2024 Author(s) : Leong Sze Wei Source : DARU-JOURNAL OF PHARMACEUTICAL SCIENCES DOI : 10.1007/s40199-024-00542-x
5.	Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages 2024 Author(s) : Leong Sze Wei Source : FUTURE MEDICINAL CHEMISTRY DOI : 10.4155/fmc-2023-0174
6.	Indole Schiff Base Complex: Synthesis and Optical Binding Investigation with Biogenic Amines 2024 Author(s) : Muhammad Kumayl Bin Abdul Wahab, Muhammad Ameerullah Bin Sahudin, Leong Sze Wei Source : JOURNAL OF FLUORESCENCE DOI : 10.1007/s10895-024-03854-y
7.	Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway 2024 Author(s) : Leong Sze Wei Source : ACTA PHARMACOLOGICA SINICA DOI : 10.1038/s41401-024-01254-3
8.	Exploring the potential of chromone scaffold compounds in cancer therapy: targeting key kinase pathways 2023 Author(s) : Leong Sze Wei Source : Medicinal Chemistry Research DOI : 10.1007/s00044-023-03063-5
9.	Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells 2023 Author(s) : Leong Sze Wei Source : European Journal of Medicinal Chemistry DOI : 10.1016/j.ejmech.2023.115335
10.	Curcumin-like diarylpentanoid analogues inhibit influenza A virus (H1N1) replication and pro-inflammatory cytokines production in A549 lung epithelial cells 2023 Author(s) : Leong Sze Wei Source : RESPIROLOGY
11.	Exploring the potential of chromone scaffold compounds in cancer therapy: targeting key kinase pathways 2023 Author(s) : Leong Sze Wei Source : MEDICINAL CHEMISTRY RESEARCH DOI : https://doi.org/10.1007/s00044-023-03063-5
12.	Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells 2023 Author(s) : Leong Sze Wei Source : EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY DOI : https://doi.org/10.1016/J.EJMECH.2023.115335
13.	Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages 2023 Author(s) : Leong Sze Wei Source : Future Medicinal Chemistry
14.	Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells 2023 Author(s) : Leong Sze Wei Source : EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY DOI : 10.1016/j.ejmech.2023.115335
15.	Exploring the potential of chromone scaffold compounds in cancer therapy: targeting key kinase pathways 2023 Author(s) : Leong Sze Wei Source : MEDICINAL CHEMISTRY RESEARCH DOI : 10.1007/s00044-023-03063-5
16.	In silico studies, nitric oxide, and cholinesterases inhibition activities of pyrazole and pyrazoline analogs of diarylpentanoids 2021 Author(s) : Leong Sze Wei Source : Archiv Der Pharmazie
17.	Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1α interaction in lung cancer 2021 Author(s) : Leong Sze Wei Source : Cell Death and Disease
18.	Persistent Newcastle disease virus infection in bladder cancer cells is associated with putative pro-survival and anti-viral transcriptomic changes. 2021 Author(s) : Leong Sze Wei Source : BMC Cancer
19.	Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice 2021 Author(s) : Leong Sze Wei Source : Scientific Reports
20.	The involvement of l-arginine-nitric oxide-cgmp-atp-sensitive k+ channel pathway in antinociception of bbhc, a novel diarylpentanoid analogue, in mice model 2021 Author(s) : Leong Sze Wei Source : Molecules
21.	Metallointercalator [Ru(dppz)2(PIP)]2+ Renders BRCA Wild-Type Triple-Negative Breast Cancer Cells Hypersensitive to PARP Inhibition 2020 Author(s) : Leong Sze Wei Source : ACS Chemical Biology
22.	In-vitro and in-silico evaluations of heterocyclic-containing diarylpentanoids as Bcl-2 inhibitors against lovo colorectal cancer cells. 2020 Author(s) : Leong Sze Wei Source : Molecules
23.	Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis 2020 Author(s) : Leong Sze Wei Source : Bioorganic Chemistry
24.	Identification of α-glucosidase inhibitory compounds from Curcuma mangga fractions. 2020 Author(s) : Leong Sze Wei Source : International Journal of Food Properties
25.	Synthesis and in vitro biological evaluations of novel tetrapeptide as therapeutic agent for wound treatment 2020 Author(s) : Leong Sze Wei Source : Journal of Saudi Chemical Society
26.	Synthesis and in-vitro anti-cancer evaluations of multi-methoxylated asymmetrical diarylpentanoids as intrinsic apoptosis inducer against colorectal cancer 2020 Author(s) : Leong Sze Wei Source : Bioorganic and Medicinal Chemistry Letters
27.	Anti-edematogenic and anti-granuloma activity of a synthetic curcuminoid analog, 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one, in mouse models of inflammation. 2019 Author(s) : Leong Sze Wei Source : Molecules
28.	Synthesis and biological evaluation of asymmetrical diarylpentanoids as antiinflammatory, anti-α-glucosidase, and antioxidant agents 2019 Author(s) : Leong Sze Wei Source : Medicinal Chemistry Research
29.	Effect of diarylpentanoid analogues on lipopolysaccharide-induced interleukin-6 and interleukin-8 gene expression in airway inflammation 2019 Author(s) : Leong Sze Wei Source : Malaysian Journal of Medicine and Health Sciences
30.	Novel 2-Benzoyl-6-(2,3-Dimethoxybenzylidene)-Cyclohexenol Confers Selectivity toward Human MLH1 Defective Cancer Cells through Synthetic Lethality 2019 Author(s) : Leong Sze Wei Source : SLAS Discovery
31.	Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics 2019 Author(s) : Leong Sze Wei Source : Journal of Food Composition and Analysis
32.	Chemical constituents and biological activities of south east asia marine sponges: A review 2019 Author(s) : Leong Sze Wei Source : Pertanika Journal of Science and Technology
33.	Induction of cell cycle arrest and apoptosis by copper complex Cu(SBCM)2 towards oestrogen-receptor positive MCF-7 breast cancer cells. 2019 Author(s) : Leong Sze Wei Source : RSC Advances
34.	Asymmetrical meta-methoxylated diarylpentanoids: Rational design, synthesis and anti-cancer evaluation in-vitro. 2018 Author(s) : Leong Sze Wei Source : European Journal of Medicinal Chemistry
35.	In vitro and in silico evaluations of diarylpentanoid series as α-glucosidase inhibitor 2018 Author(s) : Leong Sze Wei Source : Bioorganic and Medicinal Chemistry Letters
36.	Analgesic effect of 5-(3,4-Dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one in experimental animal models of nociception. 2018 Author(s) : Leong Sze Wei Source : Molecules
37.	Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives 2017 Author(s) : Kamal Rullah, Kamal Rullah, Leong Sze Wei Source : Medicinal Chemistry Research DOI : 10.1007/s00044-017-2025-4
38.	Effect of different drying methods and solvent ratios on biological activities of Phyllanthus acidus extracts 2017 Author(s) : Leong Sze Wei Source : International Food Research Journal
39.	Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology. 2017 Author(s) : Leong Sze Wei Source : Chemistry Central Journal
40.	Comparative study of the antioxidant activities of some lipase-catalyzed alkyl dihydrocaffeates synthesized in ionic liquid 2017 Author(s) : Leong Sze Wei Source : Food Chemistry
41.	Zebrafish phenotypic screen identifies novel Notch antagonists 2017 Author(s) : Leong Sze Wei Source : Investigational New Drugs
42.	Alpha-Glucosidase Inhibitory and Antioxidant Activities of Different Ipomoea aquatica Cultivars and LC MS/MS Profiling of the Active Cultivar 2017 Author(s) : Leong Sze Wei Source : Journal of Food Biochemistry.
43.	Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA 2016 Author(s) : Leong Sze Wei Source : RSC Advances
44.	Chemical constituents and biological activities of Callicarpa maingayi leaves 2016 Author(s) : Leong Sze Wei Source : South African Journal of Botany
45.	Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines 2016 Author(s) : Leong Sze Wei Source : Bioorganic and Medicinal Chemistry Letters
46.	Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells 2016 Author(s) : Leong Sze Wei Source : RSC Advances
47.	2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase 2016 Author(s) : Leong Sze Wei Source : Bioorganic and Medicinal Chemistry
48.	Phytochemical diversity of Clinacanthus nutans extracts and their bioactivity correlations elucidated by NMR based metabolomics 2015 Author(s) : Leong Sze Wei Source : Phytochemistry Letters
49.	Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives 2015 Author(s) : Leong Sze Wei Source : Bioorganic and Medicinal Chemistry Letters
50.	Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors 2015 Author(s) : Leong Sze Wei Source : MedChemComm
51.	Synthesis, bioactivity evaluation, and docking study of 5-aminosalicylic acid’s fatty acid derivatives 2015 Author(s) : Leong Sze Wei Source : Monatshefte Fur Chemie
52.	Differentiation of Nigella sativa seeds from four different origins and their bioactivity correlations based on NMR-metabolomics approach 2015 Author(s) : Leong Sze Wei Source : Phytochemistry Letters
53.	Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents 2014 Author(s) : Leong Sze Wei Source : Molecules
54.	Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation 2014 Author(s) : Kamal Rullah, Leong Sze Wei Source : Bioorganic & Medicinal Chemistry Letters DOI : 10.1016/j.bmcl.2014.06.061

BOOK

NO	DETAILS OF BOOK

PROCEEDING

NO	DETAILS OF PROCEEDING

RESEARCH PROJECT

GRANT	PROGRESS	STATUS
Design, Synthesis And Anti-cancer Evaluation Of Phenylpyrazole-styryl Hybrids As Multi Target Agents Against Egfr And Vegfrs Researcher(s) : Prof. Dr. Cheng Sit Foon, Dr. Abdullah Al-hadi Bin Ahmad Fuaad, Associate Prof. Dr. Lim Yat Yuen		on going
Structural Optimization of AP21 as EGFR-Targeting Anti-Cancer Agents Researcher(s) : Associate Prof. Dr. Lim Yat Yuen		on going

RESEARCH COLLABORATOR

GRANT	PROGRESS	STATUS
WP2: Development of Novel Therapeutic Agent and Delivery Method for Lung Cancer Researcher(s) : Prof. Dr. Azhar Bin Ariffin, Dr. Chin Sek Peng, Dr. Leong Kok Hoong, Dr. Leong Sze Wei		on going