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Professor Amru graduated with a BSc Honours degree in Physiology from the University of Malaya in the 1974/75 session and subsequently worked briefly as an Assistant Research Officer in the Fundamental Chemistry Division at the Rubber Research Institute of Malaysia laboratories in Sungai Buloh, investigating the biochemistry of latex. After completing his PhD work from Bristol University in 1978, working on chlorophyll biosynthesis, he was appointed as lecturer in January 1979 in the Department of Botany. He was later promoted to Associate Professor in 1987 and in 2001 to Professor. In 1986 Professor Amru developed a continuous spectroscopic assay for magnesium protoporphyrin monomethyl ester cyclase, an enzyme in the chlorophyll biosynthetic pathway. In 1991, in collaboration with J. G. Duckett at the then Queen Mary & Westfield College, University of London, he reported the discovery of chloroplasts with the largest grana ever reported in the plant kingdom in the deep shade fern Teratophyllum rotundifoliatum and subsequently reported its diurnal photosynthetic activity.

Professor Amru has taught Plant Biochemistry and Basic Biochemistry amongst other subjects for almost 30 years in the University of Malaya. He was appointed Deputy Dean to the Faculty of Science twice, between 1985-1989 and later between 1998-2000. He served as the Head of the Institute of Biological Sciences for about 5 years between 2000 till 2006 and was later appointed the Dean of the Faculty of Science in 2006/2007. He is currently serving as Dean of the Advanced Fundamental Research Cluster (2011- now).