Curriculum Vitae

ASSOCIATE PROF. DR. LOW YUN YEE

Associate Professor
  • Department of Chemistry
    Faculty of Science
  • 03-79675165

AREAS OF EXPERTISE

  • ORGANIC CHEMICAL SYNTHESIS
    Organic Synthesis (Biomimetic Synthesis, Electroorganic Synthesis)
  • NATURAL PRODUCTS CHEMISTRY
    Alkaloid Chemistry (Structure, Chemistry, Biosynthesis)
  • PHYSICAL ORGANIC CHEMISTRY
    Reaction Mechanism (Investigation of Free-Radical and Radical Cation Mediated Transformations)
  • BIO-ORGANIC CHEMISTRY
    Bioorganic and Medicinal Chemistry (Anticancer compounds, Synthesis of Analogues for SAR studies)
  • CHARACTERIZATION OF MOLECULES
    X-Ray Crystallography (Structure Elucidation, Crystallization Phenomenon, Crystallization Techniques, Spontaneous Resolution)

ACADEMIC QUALIFICATION

  • PhD, (Organic Chemistry)
    Universiti Malaya (UM)
  • MSc, (Organic Chemistry)
    Universiti Malaya (UM)
  • BSc (Hons) (Chemistry), (Chemistry)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • Coordinator
    01 Nov 2022 - 31 Oct 2023 (Department of Chemistry, Faculty of Science)
  • Coordinator
    01 May 2020 - 31 Aug 2021 (Department of Chemistry, Faculty of Science)
  • Member of the RSC (B.Sc) document preparation
    01 Sep 2020 - 31 Aug 2021 (Department of Chemistry, Faculty of Science)
  • Coordinator
    01 Sep 2019 - 31 Aug 2021 (Department of Chemistry, Faculty of Science)
  • University of Malaya Institutional Biosafety Committee Member (UM IBC)
    08 Apr 2019 - 31 Mar 2021 (University Malaya)
  • Head of Task force to Prepare Organic 2 Laboratory Video
    01 Aug 2020 - 16 Sep 2020 (Department of Chemistry, Faculty of Science)
  • AJK Keselamatan Sinaran
    01 Apr 2017 - 31 Mar 2019 (University Malaya)
  • Panel Jawatankuasa Tatatertib Pelajar
    27 Mar 2019 - 27 Mar 2019 (University Malaya)
  • Coordinator for M.Sc. (Research)
    01 Oct 2013 - 25 Aug 2017 (Department of Chemistry, Faculty of Science)
  • University of Malaya Institutional Biosafety Committee Member (UM IBC)
    01 Apr 2015 - 31 Mar 2017 (University Malaya)
  • Undergraduate Student's Yearly Activity Committee
    24 Oct 2013 - 31 Dec 2015 (Department of Chemistry, Faculty of Science)

MEMBERSHIPS

  • MALAYSIAN INSTITUTE OF CHEMISTRY, MEMBER
    Since 2014 (National)

AWARD AND STEWARDSHIP

  • Invited Speaker for the 8th Asian Network for Natural & Unnatural Materials (8th ANNUM)
    Asian Network for Natural & Unnatural Materials, 2021 (International)
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2021 (University)
  • Best Poster Award
    Faculty of Science, University of Malaya, 2018 (International)
  • Merck Young Scientist Award
    Merck (M) Sdn. Bhd., 2010 (International)

PUBLICATIONS

Article in Journal
WoS
  1. Lee, Fong-Kai; Chan, Nathaniel Jia-Yoong; Krishnan, Premanand; Salam, Dayang Sharyati Datu Abdul; Chee, Xavier Wezen; Muhamad, Azira; Low, Yun-Yee; Ting, Kang-Nee; Lim, Kuan-Hon (2024). Preparation and Preliminary Structure-Activity Relationship Studies of Schwarzinicine A Analogs as Vasorelaxant Agents, JOURNAL OF NATURAL PRODUCTS. . doi:10.1021/acs.jnatprod.3c00707
  2. Tan, Yi-Sheng; Ng, Min-Phin; Tan, Chun-Hoe; Tang, Wai-Kit; Sim, Kae-Shin; Yong, Kien-Thai; Krishnan, Premanand; Lim, Kuan-Hon; Lim, Siew-Huah; Low, Yun-Yee (2024). Quinoline, Indole, and Isogranatanine Alkaloids from Malayan Leuconotis eugeniifolia, JOURNAL OF NATURAL PRODUCTS. 87(2), 286-296. doi:10.1021/acs.jnatprod.3c00960
  3. Nett, Ryan S.; Dho, Yaereen; Tsai, Chun; Passow, Daria; Grundman, Jaime Martinez; Low, Yun-Yee; Sattely, Elizabeth S. (2023). Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis, NATURE. 624(7990), 182-+. doi:10.1038/s41586-023-06716-y
  4. Tan, Yi-Sheng; Wong, Soon-Kit; Yong, Kien-Thai; Lim, Kuan-Hon; Lim, Siew-Huah; Low, Yun-Yee (2023). Eugeniifoline, a Pentacyclic Indole Alkaloid from Leuconotis eugeniifolia, and Configurational Revision of Synthetic Eugeniifoline Isolated from a Diversity-Enhanced Extract, JOURNAL OF NATURAL PRODUCTS. . doi:10.1021/acs.jnatprod.2c00731
  5. Tang, Sin-Yee; Ng, Min-Phin; Tan, Chun-Hoe; Sim, Kae-Shin; Lim, Kuan-Hon; Yong, Kien-Thai; Low, Yun-Yee; Lim, Siew-Huah (2023). Chippiine, iboga, cleavamine, vobasine, and cytotoxic bisindole alkaloids from Tabernaemontana polyneura, TETRAHEDRON. 149. doi:10.1016/j.tet.2023.133706
  6. Tang, Sin-Yee; Tan, Chun-Hoe; Sim, Kae-Shin; Yong, Kien-Thai; Lim, Kuan-Hon; Low, Yun-Yee; Lim, Siew-Huah (2023). Polyneurines A-H, iboga alkaloids from Tabernaemontana polyneura, PHYTOCHEMISTRY. 208. doi:10.1016/j.phytochem.2023.113587
  7. Chan, Z. Y., Krishnan, P., Modaresi, S. M., Hii, L. W., Mai, C. W., Lim, W. M., . . . Lim, K. H. (2021). Monomeric, Dimeric, and Trimeric Tropane Alkaloids from Pellacalyx saccardianus. Journal of natural products, 84(8), 2272-2281. doi: 10.1021/acs.jnatprod.1c00374
  8. Nett, R. S., Dho, Y., Low, Y. Y., & Sattely, E. S. (2021). A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America, 118(24), 12. doi: 10.1073/pnas.2102949118|1of12
  9. Tan, C. H., Yeap, J. S. Y., Lim, S. H., Low, Y. Y., Sim, K. S., & Kam, T. S. (2021). The Bisindole Alkaloids Angustilongines M and A from Alstonia penangiana Induce Mitochondrial Apoptosis and G0/G1 Cell Cycle Arrest in HT-29 Cells through Promotion of Tubulin Polymerization. Journal of natural products, 84(5), 1524-1533. doi: 10.1021/acs.jnatprod.1c00013
  10. Wong, S. K., Yeap, J. S. Y., Tan, C. H., Sim, K. S., Lim, S. H., Low, Y. Y., & Kam, T. S. (2021). Arbolodinines A-C, biologically-active aspidofractinine-aspidofractinine, aspidofractinine-strychnan, and kopsine-strychnan bisindole alkaloids from Kopsia arborea. Tetrahedron, 78, 9. doi: 10.1016/j.tet.2020.131802
  11. Krishnan, P., Lee, F. K., Yap, V. A., Low, Y. Y., Kam, T. S., Yong, K. T., . . . Lim, K. H. (2020). Schwarzinicines A-G, 1,4-Diarylbutanoid-Phenethylamine Conjugates from the Leaves of Ficus schwarzii. Journal of natural products, 83(1), 152-158. doi: 10.1021/acs.jnatprod.9b01160
Scopus
  1. Nett R.S., Dho Y., Tsai C., Passow D., Martinez Grundman J., Low Y.-Y., Sattely E.S. (2023). Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis, Nature. . doi:10.1038/s41586-023-06716-y
  2. Tan Y.-S., Wong S.-K., Yong K.-T., Lim K.-H., Lim S.-H., Low Y.-Y. (2023). Eugeniifoline, a Pentacyclic Indole Alkaloid from Leuconotis eugeniifolia, and Configurational Revision of Synthetic Eugeniifoline Isolated from a Diversity-Enhanced Extract, Journal of natural products. 86(1), 232-236. doi:10.1021/acs.jnatprod.2c00731
  3. Tang S.-Y., Ng M.-P., Tan C.-H., Sim K.-S., Lim K.-H., Yong K.-T., Low Y.-Y., Lim S.-H. (2023). Chippiine, iboga, cleavamine, vobasine, and cytotoxic bisindole alkaloids from Tabernaemontana polyneura, Tetrahedron. 149. doi:10.1016/j.tet.2023.133706
  4. Tang S.-Y., Tan C.-H., Sim K.-S., Yong K.-T., Lim K.-H., Low Y.-Y., Lim S.-H. (2023). Polyneurines A H, iboga alkaloids from Tabernaemontana polyneura, Phytochemistry. 208. doi:10.1016/j.phytochem.2023.113587
  5. Cho E.-S., Krishnan P., Loh H.-S., Daly J.M., Leong C.-O., Mai C.-W., Low Y.-Y., Yong K.-T., Lim K.-H. (2022). Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus, Phytochemistry. 193. doi:10.1016/j.phytochem.2021.112988
  6. Sim D.S.-Y., Tang S.-Y., Low Y.-Y., Lim S.-H., Kam T.-S. (2022). Vobasine, vincamine, voaphylline, tacaman, and iboga alkaloids from Tabernaemontana corymbosa, Phytochemistry. 203. doi:10.1016/j.phytochem.2022.113384
  7. Tan C.H., Sim D.S.Y., Lim S.H., Mohd Mohidin T.B., Mohan G., Low Y.Y., Kam T.S., Sim K.S. (2022). Antiproliferative and Microtubule-stabilizing Activities of Two Iboga-vobasine Bisindoles Alkaloids from Tabernaemontana corymbosa in Colorectal Adenocarcinoma HT-29 Cells, Planta Medica. 88(14), 1325-1340. doi:10.1055/a-1755-5605
  8. Wong S.-K., Tan Y.-S., Lim S.-H., Low Y.-Y., Kam T.-S. (2022). Arboduridine, a hexacyclic caged monoterpenoid indole incorporating cyclohexane, piperidine, and bridged-fused pyrrolidine-tetrahydrofuran moieties, Tetrahedron Letters. 98. doi:10.1016/j.tetlet.2022.153836
Others
  1. Lee, Fong-Kai; Krishnan, Premanand; Muhamad, Azira; Low, Yun-Yee; Kam, Toh-Seok; Ting, Kang-Nee; Lim, Kuan-Hon, Concise synthesis of the vasorelaxant alkaloids schwarzinicines A and B, Natural Product Research,
  2. Al-Khdhairawi, A. A. Q.; Low, Y. Y.; Manshoor, N.; Arya, A.; Jelecki, M.; Alshawsh, M. A.; Kamran, S.; Suliman, R. S.; Low, A.; Shivanagere Nagojappa, N. B.; Weber, J. F. F. Asperginols A and B, Diterpene Pyrones, from an Aspergillus sp. and the Structure Revision of Previously Reported Analogues, J. Nat. Prod., 2020, 83, 230-239.
  3. Chun Hoe Tan, Dawn Su Yin Sim, Mok Piew Heng, Siew Huah Lim, Yun Yee Low, Toh Seok Kam, Kae Shin Sim, Evaluation of DNA Binding and Topoisomerase I Inhibitory Activities of 16 Decarbomethoxydihydrovoacamine from Tabernaemontana corymbosa, Chemistry Select, 2020, 5, 14839-14843.
  4. Premanand Krishnan; Fong-Kai Lee; Veronica Alicia Yap; Yun-Yee Low; Toh-Seok Kam; Kien-Thai Yong; Kang-Nee Ting; Kuan-Hon Lim. (2020) Schwarzinicines A G, 1,4-Diarylbutanoid Phenethylamine Conjugates from the Leaves of Ficus schwarzii, J. Nat. Prod. 2020, 83, 1, 152 158
  5. Chan, Zi-Yang; Govindaraju, Kayatri; Krishnan, Premanand; Low, Yun-Yee; Chong, Kam-Weng; Yong, Kien-Thai; Ting, Kang-Nee; Lim, Kuan-Hon. Diphenethylpiperidine alkaloids with tracheal smooth muscle relaxation activity from Hippobroma longiflora (L.) G. Don, Phytochemistry Letters, 2019, 30, 93-98.
  6. Chong, Kam-Weng; Thomas, Noel F.; Low, Yun-Yee; Kam, Toh-Seok. (2019). Reactions of Anodically Generated Methoxystilbene Cation Radicals: The Influence of Ortho- Substituted Vinyl and Formyl Groups, Journal of Organic Chemistry, 84(11), 7279-7290.
  7. Joanne Soon-Yee Yeap; Kuan-Hon Lim; Kien-Thai Yong; Siew-Huah Lim; Toh-Seok Kam; Yun-Yee Low. Lycopodium Alkaloids: Lycoplatyrine A, an Unusual Lycodine Piperidine Adduct from Lycopodium platyrhizoma and the Absolute Configurations of Lycoplanine D and Lycogladine H. Journal of Natural Products, 2019, 82, 324 329.
  8. Krishnan, Premanand; Mai, Chun-Wai; Yong, Kien-Thai; Low, Yun-Yee; Lim, Kuan-Hon. Alstobrogaline, an unusual pentacyclic monoterpenoid indole alkaloid with aldimine and aldimine- N- oxide moieties from Alstonia scholaris, Tetrahedron Letters (2019), 60(11), 789-791.
  9. Sim, Dawn Su-Yin; Navanesan, Suerialoasan; Sim, Kae Shin; Gurusamy, Subramaniam; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok. Conolodinines A D, Aspidosperma-Aspidosperma Bisindole Alkaloids with Anti-proliferative Activity from Tabernaemontana corymbosa, 2019, Submitted for publication on 2 Nov 2018.
  10. Wong, Soon-Kit; Wong, Suet-Pick; Sim, Kae-Shin; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok. A Cytotoxic Indole Characterized by Incorporation of a Unique Carbon- Nitrogen Skeleton and Two Pentacyclic Corynanthean Alkaloids Incorporating a Substituted Tetrahydrofuranone Ring from Kopsia arborea, 2019, 82(7), 1902-1907.
  11. Yeap, Joanne Soon-Yee; Saad, Hazwani Mat; Tan, Chun-Hoe; Sim, Kae-Shin; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok, Macroline- sarpagine bisindole alkaloids with antiproliferative activity from Alstonia penangiana, Journal of Natural Products, 2019, 82(11), 3121-3132
  12. Ezeoke, Margret Chinonso; Krishnan, Premanand; Sim, Dawn Su-Yin; Lim, Siew-Huah; Low, Yun-Yee; Chong, Kam-Weng; Lim, Kuan-Hon. Unusual phenethylamine- containing alkaloids from Elaeocarpus tectorius, Phytochemistry, 2018, 146, 75-81.
  13. Joanne Soon-Yee Yeap; Suerialoasan Navanesan; Kae-Shin Sim; Kien-Thai Yong; Subramaniam Gurusamy; Siew-Huah Lim; Yun-Yee Low; Toh-Seok Kam. (2018). Ajmaline, Oxindole, and Cytotoxic Macroline Akuammiline Bisindole Alkaloids from Alstonia penangiana, J. Nat. Prod., 81(5), 1266 1277.
  14. Kam-Weng Chong, Noel F. Thomas, Yun-Yee Low, and Toh-Seok Kam. (2018). Reactivity of Anodically Generated 4-Methoxystilbene Cation Radicals: The Influence of Ortho-Substituted Hydroxymethyl, Aminomethyl, and Carboxylic Acid Groups, Journal of Organic Chemistry, Journal of Organic Chemistry, 2018, 83, 15087 15100.
  15. Premanand Krishnan, Fong-Kai Lee, Kam-Weng Chong, Chun-Wai Mai, Azira Muhamad, Siew-Huah Lim, Yun-Yee Low, Kang-Nee Ting, and Kuan-Hon Lim. Alstoscholactine and Alstolaxepine, Monoterpenoid Indole Alkaloids with -Lactone-Bridged Cycloheptane and Oxepane Moieties from Alstonia scholaris, Organic Letters, 2018, 20, 8014 8018.
  16. Amjad Ayad Qatran Al-Khdhairawi; Premanand Krishnan; Chun-Wai Mai; Felicia Fei-Lei Chung; Chee-Onn Leong; Kien-Thai Yong; Kam-Weng Chong; Yun-Yee Low; Toh-Seok Kam; Kuan-Hon Lim. A Bis-benzopyrroloisoquinoline Alkaloid Incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine Alkaloid with Cytotoxic Activity from Ficus fistulosa var. tengerensis. J. Nat. Prod., 2017, 80 (10), 2734 2740.
  17. Kam-Weng Chong; Fong-Jiao Hong; Noel F. Thomas;, Yun-Yee Low; Toh-Seok Kam, Electrochemically Mediated Oxidative Transformations of Substituted 4-Methoxystilbenes: Effect of Ortho-Substituted Nucleophilic Groups, J. Org. Chem., 2017, 82 (12), 6172 6191.
  18. Kam-Weng Chong; Joanne Soon-Yee Yeap; Siew-Huah Lim; Jean-Fr d ric F. Weber; Yun-Yee Low; Toh-Seok Kam. Biosynthetic Enantiodivergence in the Eburnane Alkaloids from Kopsia. J. Nat. Prod., 2017, 80 (11), 3014 3024.
  19. Choy-Eng Nge; Kae-Shin Sim; Siew-Huah Lim; Noel F. Thomas; Yun-Yee Low; Toh-Seok Kam, A Hexacyclic, Iboga-Derived Monoterpenoid Indole with a Contracted Tetrahydroazepine C Ring and Incorporation of an Isoxazolidine Moiety, a Seco-Corynanthean, an AspidospermaAspidosperma Bisindole with Anticancer Properties, and the Absolute Configuration of the Pyridopyrimidine Indole Alkaloid, Vernavosine, 2016, 79, 2709 2717.
  20. Nge, Choy-Eng; Chong, Kam-Weng; Thomas, Noel F.; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok, 2016. Ibogan, Aspidosperman, Vincamine, and Bisindole Alkaloids from a Malayan Tabernaemontana corymbosa: Iboga Alkaloids with C-20 Substitution, J. Nat. Prod., 79, 1388 1399.
  21. Sim, Dawn Su-Yin; Teoh, Wuen-Yew; Sim, Kae-Shin; Lim, Siew-Huah; Thomas, Noel F.; Low, Yun-Yee; Kam, Toh-Seok, 2016. Vobatensines A- F, Cytotoxic Iboga- Vobasine Bisindoles from Tabernaemontana corymbosa, J. Nat. Prod., 79, 1048-1055.
  22. Wai-Sum Yap; Chew-Yan Gan; Kae-Shin Sim; Siew-Huah Lim; Yun-Yee Low; Toh-Seok Kam. Aspidofractinine and Eburnane Alkaloids from a North Borneo Kopsia. Ring- Contracted, Additional Ring-Fused, and Paucidactine- Type Aspidofractinine Alkaloids from K. pauciflora, 2016, 79, 230-239.
  23. Wong, Suet-Pick Chong, Kam-Weng Lim, Kuan-Hon Lim, Siew-Huah Low, Yun-Yee Kam, Toh-Seok, 2016. Arborisidine and Arbornamine, Two Monoterpenoid Indole Alkaloids with New Polycyclic Carbon-Nitrogen Skeletons Derived From a Common Pericine Precursor, Org. Lett., 18, 1618 1621
  24. Yap. V. A.; Qazzaz, M. E.; Raja, V. J.; Bradshaw, T. D.; Loh, H. S.; Sim, K. S.; Yong, K. T.; Low, Y. Y.; Lim, K. H.Fistulopsines A and B Antiproliferative Septicine-Type Alkaloids from Ficus fistulosa, Phytochemistry Phytochem. Lett., 2016, 15, 136-141.
  25. Fong-Jiao Hong, Kam-Weng Chong, Yun-Yee Low, Noel F. Thomas and Toh-Seok Kam, Transformations of Ferric Chloride-Generated Stilbene, Chem. Asian J., 2015, Ahead of Print Cation Radicals. The Effect of Aromatic Substitution and a Comparison with Anodic Oxidation, Chem. Asian. J., 2015, 10, 2207-2220.
  26. Kuan-Hon Lim, Vijay J. Raja, Tracey D. Bradshaw, Siew-Huah Lim, Yun-Yee Low, and Toh-Seok Kam. Ibogan, Tacaman, and Cytotoxic Bisindole Alkaloids from Tabernaemontana. Cononusine, an Iboga Alkaloid with Unusual Incorporation of a Pyrrolidone Moiety. J. Nat. Prod., 2015, 78 (5), 1129 1138.
  27. Lim Jun-Lee; Lim Siew-Huah; Low Yun-Yee; Sim Kae- Shin; Yong Kien-Thai; Loong Bi-Juin; Ting Kang-Nee; Kam Toh-Seok. Biologically active vallesamine, strychnan, and rhazinilam alkaloids from Alstonia: Pneumatophorine, a nor-secovallesamine with unusual incorporation of a 3-ethylpyridine moiety. Phytochemistry, 2015, 117, 317-324.
  28. Wong, Suet-Pick; Gan, Chew-Yan; Lim, Kuan-Hon; Ting, Kang-Nee; Low, Yun-Yee; Kam, Toh-Seok. Arboridinine, a Pentacyclic Indole Alkaloid with a New Cage Carbon- Nitrogen Skeleton Derived from a Pericine Precursor. Organic Letters, 2015, 17(14), 3628-3631.
  29. Yap, V. A.; Loong, B. J.; Ting, K. N.; Loh, S. H. S.; Yong, K. T., Low, Y. Y.; Kam, T. S.; Lim, K. H. Hispidacine, an unusual 8,40-oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn. Phytochemistry, 2015, 109, 96-102.
  30. Gan, C. Y.; Yoganathan, K.; Sim, K. S.; Low. Y. Y.;Lim, S. H.; Kam, T. S. Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora, Phytochemistry, 2014, 108, 234-242.
  31. Hong, F. J.; Low, Y. Y.; Chong, K. W.; Thomas, N. F.; Kam, T. S. Biomimetic Oxidative Dimerization of Anodically Generated Stilbene Radical Cations: Effect of Aromatic Substitution on Product Distribution and Reaction Pathways, J. Org. Chem. 2014, 79, 4528-4543.
  32. Lim, S. H.; Low, Y. Y.; Sinniah, S. K.; Yong, K. T.; Sim, K. S.; Kam, T. S. Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla, 2014, 98, 204-215.
  33. Low, Y. Y.; Gan, C. Y.; Kam, T. S. Andransinine: An Unusual Case of Spontaneous Resolution in an Indole Alkaloid Derivative, J. Nat. Prod. 2014, 77, 1532−1535.
  34. Low, Y. Y.; Hong, F. J.; Lim, K. H.; Thomas, N. F.; Kam, T. S. Transformations of the 2,7-Seco Aspidosperma Alkaloid Leuconolam, Structure Revision of epi- Leuconolam, and Partial Syntheses of Leuconoxine and Leuconodines A and F. J. Nat. Prod., 2014, 77, 327-338.
  35. Sim, D. S.-Y.; Chong, K. W.; Nge, C. E.; Low, Y. Y.; Sim, K. S.; Kam, T. S. Cytotoxic Vobasine, Tacaman, and Corynanthe-Tryptamine Bisindole Alkaloids from Tabernaemontana and Structure Revision of Tronoharine. J. Nat. Prod., 2014, 77, 2504-2512.
  36. Tan, S. J.; Lim, J. L.; Low, Y. Y.; Sim, K. S.; Lim, S. H.; Kam, T. S. Oxidized Derivatives of Macroline, Sarpagine, and Pleiocarpamine Alkaloids from Alstonia angustifolia, J. Nat. Prod. 2014, 77, 2068-2080.
  37. g.Nge, C. Y.; Gan, C. Y.; Lim, K. H.; Ting, K. N.; Low, Y. Y.; Kam, T. S. Criofolinine and Vernavosine, New Pentacyclic Indole Alkaloids Incorporating Pyrroloazepine and Pyridopyrimidine Moieties Derived From a Common Yohimbine Precursor. Org. Lett. 2014, 16, 6330−6333.
  38. Gan, C. Y.; Low Y. Y.; Thomas N. F; Kam T. S. Rhazinilam-leuconolam-leuconoxine alkaloids from Leuconotis griffithii, J. Nat. Prod., 2013, 76, 957- 964.
  39. Lim, S. H.; Low Y. Y.; Subramaniam G.; Abdullah Z.; Thomas N. F; Kam T. S. Lumusidines A D and villalstonidine F, macroline-macroline and macroline- pleiocarpamine bisindole alkaloids from Alstonia macrophylla, Phytochemistry, 2013, 87, 148-156.
  40. Nge, C. E.; Gan, C. Y.; Low Y. Y.; Thomas, N. F.; Kam T. S. Voatinggine and tabertinggine, pentacyclic indole alkaloids derived from an iboga precursor via a common cleavamine-type intermediate, Org. Lett., 2013, 15, 4774-4777.
  41. Lim, S. H.; Tan, S. J.; Low, Y. Y.; Lim, K. H.; Thomas, N. F.; Kam, T. S. Perhentidines A-C: macroline- macroline bisindoles from Alstonia and the absolute configuration of perhentinine and macralstonine, J. Nat. Prod., 2012, 74, 942-950.
  42. Ku, W. F.; Tan, S. J.; Low, Y. Y.; Komiyama, K.; Kam, T. S. Angustilobine and andranginine type indole alkaloids and an uleine-secovallesamine bisindole alkaloid from Alstonia angustiloba, Phytochemistry, 2011, 72, 2212- 2218.
  43. Lim, S. H.; Tan, S. J.; Low, Y. Y.; Kam, T. S. Lumutinines A-D, linearly fused macroline-macroline and macroline-sapargine bisindole from Alstonia macrophylla, J. Nat. Prod., 2011, 74, 2556-2562.
  44. Yap, W. S.; Gan, C. Y.; Low, Y. Y.; Choo, Y. M.; Etoh, T.; , E.; Hayashi, M.; Komiyama, K.; Kam, T. S. Grandilodines A-C, biologically active indole alkaloids from Kopsia grandifolia, J. Nat. Prod., 2011, 74, 1309- 1312.
  45. Gan, C. Y.; Low, Y. Y.; Robinson, W. R. T.; Komiyana, K.; Kam, T. S. Aspidospermatan-aspidospermatan and eburnane- sarpagine bisindole alkaloids from Leuconotis, Phytochemistry, 2010, 71, 1365-1370.
  46. Low, Y. Y.; Lim, K. H.; Choo, Y. M.; Pang, H. S.; Etoh, T.; Hayashi, M.; Komiyama, K.; Kam, T. S. Structure, biological activity, and a biomimetic partial synthesis of the lirofolines, novel pentacylic indole alkaloids from Tabernaemontana, Tetrahedron Lett., 2010, 51, 269-272.
  47. Tan, S. J.; Low, Y. Y.; Choo, Y. M.; Zanariah, A.; Etoh, T,; Hayashi, M.; Komiyama, K.; Kam, T. S. Strychnan and secoangustilobine A type alkaloids from Alstonia spatulata. Revision of the C-20 configuration of scholaricine, J. Nat. Prod., 2010, 73, 1891-1897.
  48. Gan, C. Y.; Low, Y. Y.; Etoh, T.; Hayashi, M.; Komiyama, K.; Kam, T. S. Leuconicines A-G and (-)-eburnamaline, biologically active strychnan and eburnan alkaloids from Leuconotis. J. Nat. Prod., 2009, 72, 2098 2103.
  49. Low, Y. Y.; Subramanian, G.; Lim, K. H.; Wong, R. C. S.; Robinson, W. T.; Kam, T. S. Mersiphyllines A and B from Kopsia. Determination of relative configuration at a quaternary center via formation of an alkaloid-borane complex. Tetrahedron, 2009, 65, 6873-6876.
  50. Low, Y. Y.; Lim, K. H.; Tan, G. H.; Kam, T. S.; Lim, T. M. Kopsine and danuphylline alkaloids from Kopsia. Biomimetic partial synthesis of danuphylline B. Helvetica Chimica Acta 2008, 91, 1559 1566.
  51. Lim, K. H.; Low, Y. Y.; Kam, T. S.; Biomimetic oxidative transformations of pericine: partial synthesis of apparicine and valparicine, a new pentacyclic indole alkaloid from Kopsia. Tetrahedron Letters 2006, 47, 5037-5039.

RESEARCH PROJECT

National
  1. 2023 - 2026, Fundamental Research Grant Scheme (FRGS)
    Alkaloid Chemosystematics As An Efficient Tool For Identifying Plants Belonging To The Pandanaceae Family (benstonea, Pandanus, Or Freycinetia) ( Principal Investigator(PI))
  2. 2019 - 2023, Fundamental Research Grant Scheme (FRGS)
    Sustainable Synthesis Of The Cytotoxic Indole Alkaloid Valparicine And Investigation Of The Scope And Mechanism Of Antiproliferative Activity ( Co-Researcher)
  3. 2019 - 2022, Fundamental Research Grant Scheme (FRGS)
    Reactivity Of Anodically Generated Stilbene Cation Radicals: The Effect Of Ortho Substitution By Hydroxymethyl, Aminomethyl, And Carboxylic Acid Groups ( Principal Investigator(PI))
  4. 2011 - 2015, High Impact Research (HIR)
    Biorganic and Medicinal Chemistry and Organic Synthesis ( Consultant)

PAPER PRESENTED

ORAL PRESENTER
  1. Indole Alkaloids from Kopsia arborea, 9th ASIAN NETWORK OF NATURAL & UNNATURAL MATERIALS INTERNATIONAL CONFERENCE, Department of Chemistry, University of Delhi  (International) (08 Apr 2022 - 08 Apr 2022)
  2. NMR and X-ray Crystallography in Structure Elucidation, Chemistry Department's Reactive Talk (7/2019), Department of Chemistry, Faculty of Science, University of Malaya (University) (13 Dec 2019 - 13 Dec 2019)
POSTER PRESENTER
  1. Anti-proliferative Effects Exhibited by DNA Minor Groove Binding Alkaloids from Tabernaemontana corymbosa on Human Colorectal Cancer Cells, Biological Sciences Graduate Congress, Institute of Biological Sciences,  (International) (19 Dec 2019 - 20 Dec 2019)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2021) Thesis Seminar - Chan Cheang Wei (17049951/2), University, (Internal Assessor)
  2. (2021) Journal Article Review for Journal of Ethnopharmacology, International, (Reviewer)
  3. (2021) Fast Track Evaluation - Muhammad Haniff Mokti (17119564), University, (Internal Assessor)
  4. (2021) Confirmation Candidature Defence - Chan Wei Chuen (17151681/2), University, (Internal Assessor)
  5. (2021) Journal Article Review for Phytochemistry, International, (Reviewer)
  6. (2021) Frgs Research Grant Proposal Evaluation (Faculty Level), University, (Internal Evaluator)
  7. (2021) Journal Article Review for Phytochemistry, International, (Reviewer)
Contribution to external organisation
  1. (2020) Research Collaboration, University of Nottingham Malaysia Campus, National
Contribution to event
  1. (2021) Session Chairperson for 33rd International Conference of Analytical Sciences (Skam33), National, (Panelist/Moderator)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2023) BIOLOGICALLY ACTIVE INDOLE AND BISINDOLE ALKALOIDS FROM KOPSIA ARBOREA, WONG SOON KIT
  2. (2023) STRUCTURE AND BIOLOGICAL ACTIVITY OF ALKALOIDS FROM Leuconotis eugeniifolia, TAN YI SHENG
  3. (2023) Chemical Investigations and Antiproliferative Activities of the Alkaloids from Tabernaemontana polyneura, TANG SIN YEE
  4. (2019) BIOLOGICALLY ACTIVE ALKALOIDS FROM ALSTONIA AND LYCOPODIUM, JOANNE YEAP SOON YEE
  5. (2018) REACTIVITY OF ANODICALLY-GENERATED METHOXYSTILBENE CATION RADICALS: THE EFFECT OF ORTHO'-SUBSTITUTION, CHONG KAM WENG
  6. (2014) Electroorganic Synthesis and Mechanisms: Electrochemically-mediated oxidation of trans-1,2-disubstituted alkenes - Mechanistic studies and synthetic applications, Chong Kam Weng
  7. (2014) Chemical Investigations of the Alkaloids of Alstonia and Lycopodium Species, Joanne Yeap Soon Yee
  8. (2013) Alkaloids from Alsronia scholaris and Ficus Schwarzii, Premanand a/l Krishnan (University of Nottingham Malaysia Campus)
Master
  1. (2015) ALKALOIDS FROM KOPSIA ARBOREA, WONG SUET PICK
  2. (2014) ELECTROORGANIC SYNTHESIS AND MECHANISMS: ELECTROCHEMICALLY-MEDIATED OXIDATION OF TRANS-1,2-DISUBSTITUTED ALKENES - MECHANISTIC STUDIES AND SYNTHETIC APPLICATIONS, CHONG KAM WENG
  3. (2014) ALKALOIDS FROM ALSTONIA PNEUMATOPHORA AND ALSTONIA ROSTRATA, LIM JUN LEE
  4. (2013) Biologically Active Secondary Metabolites from Plants, Wong Suet Pick
  5. (2012) Biologically Active Secondary Metabolites From Plants and Microbes, Lim Jun Lee
Under Graduate Students
  1. (2021) Indole alkaloids from Melodinus orientalis

TEACHING

Doctor Of Philosophy
  1. (2022) SVX8001 - Research Methodology in Science
Master
  1. (2022) SQC7007 - Mass Spectrometry and Related Techniques
  2. (2022) SMX7001 - Research Methodology in Science
  3. (2021) SQC7007 - Mass Spectrometry and Related Techniques
  4. (2021) SQC7007 - Mass Spectrometry and Related Techniques
  5. (2020) SQC7007 - Mass Spectrometry and Related Techniques
Bachelor
  1. (2022) SID3002 - Advanced Organic Chemistry
  2. (2022) SIX1002 - Ethics and Safety
  3. (2022) SIC3002 - Organic Chemistry III
  4. (2022) SIC3004 - Project
  5. (2021) SID3002 - Advanced Organic Chemistry
  6. (2021) SIC2002 - Organic Chemistry Ii
  7. (2021) SIC3004 - Project
  8. (2021) SIC2002 - Organic Chemistry Ii
  9. (2021) SIC3011 - Mechanistic Organic Chemistry
  10. (2021) SID3002 - Advanced Organic Chemistry
  11. (2020) SCES3324 - Natural Product Chemistry
  12. (2020) SCES3328 - Mechanisme Organic Chemistry
  13. (2020) SIC3004 - Project
  14. (2020) SIC3004 - Project
  15. (2020) SIC3011 - Mechanistic Organic Chemistry
  16. (2020) SID3002 - Advanced Organic Chemistry
  17. (2020) SID3002 - Advanced Organic Chemistry
  18. (2019) SIC2007 - Spectroscopic Methods in Organic Chemistry
  19. (2019) SIC3011 - Mechanistic Organic Chemistry
  20. (2017) SCES3327 - Organic Synthesis
  21. (2017) SCES3328 - Mechanisme Organic Chemistry
  22. (2016) SCES3324 - Natural Product Chemistry
  23. (2016) SCES3327 - Organic Synthesis
  24. (2015) SCES3324 - Natural Product Chemistry

SOCIAL RESPONSIBILITY ACTIVITIES

  • Malaysian International Chemistry Olympiad (Micho) Trainer, (31 May 2021 - 10 Jun 2021) (National)