Curriculum Vitae

DR. LEE YEAN KEE

Research Officer
  • Institute of Research Management and Services
  • +603-79677100

AREAS OF EXPERTISE


  • ORGANIC CHEMICAL SYNTHESIS
    BINOL, flavanoid, chalcones, benzimidazole

ACADEMIC QUALIFICATION


  • PhD, (Sains)
    Universiti Malaya (UM)
  • MSc, (Sintesis)
    Universiti Putra Malaysia (UPM)
  • BSc(Hons), (Kimia Industri)
    Universiti Putra Malaysia (UPM)

PUBLICATIONS


Article in Journal
  1. Liew, Y.J.M., Lee, Y.K., Khalid, N., Rahman, N.A., Tan, B.C. (2021). Cell-free expression of a plant membrane protein BrPT2 from Boesenbergia rotunda. Molecular Biotechnology 63(4), 316-326. https://doi.org/10.1007/s12033-021-00304-z
  2. Abdullah, AA; Lee, YK; Chin, SP; Lim, SK; Lee, VS; Othman, R; Othman, S; Rahman, NA; Yusof, R; Heh, CH 2020. Discovery of Dengue Virus Inhibitors. Current Medicinal Chemistry, 27: 4945-5036.
  3. Ramu, M; Lee, YK; Ahmad Saifuddin, MA; Iskandar, A; Mohd Nizam, M; Noorsaadah, AR. CuBr-Catalyzed One-Pot Three-Component Synthesis of Novel 2- (Carbazolyl)benzothiazoles. Accepted in Synlett
  4. Khor, S. W., Lee, Y. K., Tay, K. S., (2019) Selective magnetic mercury (II) ion capturing ligand-doped silica gel for water analysis. Analyst, 144 (6), 1968-1974.
  5. Raghavendra, S., Y. K. Lee and Venkataramana M. (2019) Solid Supported Peptide Catalyst For The Synthesis Of Flavanone And Azaflavanones, Mapana Journal Of Sciences, 18 (2): 21-28.
  6. Pei Qie Chan, Yean Kee Lee and Noorsaadah Abd. Rahman (2018) Facile Intramolecular Cyclization of N-(2-Hydroxybenzoyl)hydrazones to N,N -Diacetyl Benzo-1,3,4-oxadiazepine Derivatives, Asian Journal of Organic Chemistry, 7(4): 707-710.
  7. Thy, C.K., Murthy, S., Lee, Y.K., Yaeghoobi, M., Rahman, N.A., Chee, C.F. (2018) A Simple Aluminum Bromide-Promoted Diastereoselective Synthesis of Panduratin A Derivatives. Synlett, 29(10): 1358-1361.
  8. Wei Lian, Tan, Yean Kee, Lee, Yen Fong, Ho, Rohana Yusof, Noorsaadah Abdul Rahman, Saiful Anuar Karsani. 2018. Comparative proteomics reveals that YK51, a 4-Hydroxypandurantin-A analogue downregulates the expression of proteins associated with dengue virus infection, PeerJ, 5: e3939.
  9. Yeong KY, Tan SC, Mai C-W, Leong CO, Chung FF, Lee YK, Chee CF and Abdul Rahman N. (2018) Contrasting sirtuin and poly(ADP-ribose)polymerase activities of selected 2,4,6-trisubstituted benzimidazoles. Chem Biol Drug Des., 91(1):1 7.
  10. Gan, C.S., Lee, Y.K., Heh, C.H., Rahman, N.A., Yusof, R., Othman, S. (2017) The synthetic molecules YK51 and YK73 attenuate replication of dengue virus serotype 2. Tropical Biomedicine, 34 (2): 270-283.
  11. Khor, S. W., Lee, Y. K., Abas, M. R. B., Tay, K. S., (2017). Application of chalcone-based dithiocarbamate derivative incorporated sol gel for the removal of Hg (II) ion from water. Journal of Sol-Gel Science and Technology 82, 834 845.
  12. Mudiana M., Y. K. Lee, N. A. Rahman, R. Yusof (2017) Synthesized flavanoid-derived ligand reduced dengue virus type-2 replication in vitro, Asian Pacific Journal of Tropical Biomedicine, 7(2): 91-95
  13. Iskandar Abdullah, Chee Chin Fei, Lee Yean Kee, Siva Sanjeeva Rao Thunuguntla, K Satish Reddy, Kavitha Nellore, Thomas Antony, Jitender Verma, Kong Wai Mun, Shatrah Othman, Hosahalli Subramanya, Noorsaadah Abd Rahman.(2015) Benzimidazole Derivatives as Potential Dual Inhibitors for PARP-1 and DHODH. Bioorg Med Chem., 23(15), 4669-4680.
  14. Lee Y.K., Tay K.S., Lee S.V., Rahman N.A. (2015) A Magnetically Recyclable Heterogeneous BINOL Organocatalyst for the Asymmetric Aldol Reaction. Applied Catalysis A-General 502, 246-253.
  15. Lei Chen, Yean Kee Lee, Yanawut Manmana, Kheng Soo Tay, Vannajan Sanghiran Lee, Noorsaadah Abd Rahman, 2015. Synthesis, Characterization and Theoretical Study of Acrylamide-based Magnetic Molecularly Imprinted Polymer for Recognition of Sulfonamide Drugs. E-Polymers 15, 141-150.
  16. Takhi, M., Sreenivas, K., Reddy, C. K., Munikumar, M., Praveena, K., Sudheer, P., Rao, B., Ramakanth, G., Sivaranjani, J., Mulik, S., Reddy, Y. R., Rao, K. N., Pallavi, R., Lakshminarasimhan, A., Panigrahi, S. K., Antony, T., Abdullah, I., Lee, Y. K., Ramachandra, M., Yusof, R., Rahman, N. A., Subramanya, H. 2014. Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors. European Journal of Medicinal Chemistry.  (Tier 1, Impact Factor = 3.432)
  17. Takhi, M., Sreenivas, K., Reddy, C.K., Munikumar, M., Praveena, K., Sudheer, P., Rao, B.N.V.M., Ramakanth, G., Sivaranjani, J., Mulik, S., Reddy, Y.R., Narasimha Rao, K., Pallavi, R., Lakshminarasimhan, A., Panigrahi, S.K., Antony, T., Abdullah, I., Lee, Y.K., Ramachandra, M., Yusof, R., Rahman, N.A., Subramanya, H. (2014) Discovery of azetidine based ene- amides as potent bacterial enoyl ACP reductase (FabI) inhibitors. Eur. J. Med. Chem., 84: 382-394.
  18. Hairin, T., Marzilawati, A. R., Didi, E. M. H., Mahadeva, S., Lee, Y. K., Abd Rahman, N., Mustafa, A. M., Chik, Z. (2013) Quantitative LC/MS/MS analysis of acetaminophen-cysteine adducts (APAP-CYS) and its application in acetaminophen overdose patients. Analytical Methods, 5, 1955-1964. (Tier 2, Impact Factor = 1.855)
  19. Eng-Chong, T., Yean-Kee, L., Chin-Fei, C., Choon-Han, H., Sher-Ming, W., Li-Ping, C. T., Gen-Teck, F., Khalid, N., Abd Rahman, N., Karsani, S. A., Othman, S., Othman, R., Yusof, R. (2012) Boesenbergia rotunda: From Ethnomedicine to Drug Discovery. Evidence-Based Complementary and Alternative Medicine. 2012, 47367. (Tier 1, Impact Factor = 4.774)
  20. Lee, V. S., Lee, Y. K., Frimayanti, N., Zain, S. M., Wahab, H. A., Abd Rahman, N. (2012) Transition State Study of Cyclization Step in Peptide Catalyzed Flavanone Synthesis. AIP Conf. Proc. 1482(1), 81-84.
  21. Chee, C. F., Lee, Y. K., Buckle, M. J. C., Rahman, N. A. (2011) Synthesis of (+/-)-kuwanon V and (+/-)- dorsterone methyl ethers via Diels-Alder reaction. Tetrahedron Letters, 52(15), 1797-1799. (Tier 2, Impact Factor = 2.618)
  22. Muhamad, M, Y.K. Lee, N.A. Rahman and R. Yusof. (2010). Inhibition of dengue virus type-2 (DENV2) replication by flavanoid-derived compounds. FEBS Journal. 277 (Suppl.1): 98.
  23. Muhamad, M., Kee, L. Y., Abd Rahman, N., Yusof, R. (2010) Antiviral actions of flavanoid-derived compounds on dengue virus type-2. International Journal of Biological Sciences. 6(3), 294-302. (Tier 2, Impact Factor = 2.865)
  24. Kee, L. Y., Kiat, T. S., Wahab, H. A., Yusof, R., Rahman, N. A. (2007) Nonsubstrate Based Inhibitors of Dengue Virus Serine Protease: A Molecular Docking Approach to Study Binding Interactions between Protease and Inhibitors. Asia-Pacific Journal of Molecular Biology and Biotechnology, 15(2), 53-59.
  25. Lee, Y. K., Rozana, O., Habibah, A. W., Yusof, R., Noorsaadah, A. R. (2006) A revisit into the DEN2 NS2B/NS3 virus protease homology model: Structural verification and comparison with crystal structure of HCV NS3/4A and DEN2 NS3, Malaysian Journal of Science, 25(1), 15-22.