Curriculum Vitae

ASSOCIATE PROF. DR. YAP LEE FAH

Associate Professor
  • Department of Oral and Craniofacial Sciences
    Faculty of Dentistry
  • 0379676471

AREAS OF EXPERTISE

  • CANCER BIOLOGY

ACADEMIC QUALIFICATION

  • PHD, UNIVERSITY OF BRISTOL, UK (2007), (Sains)
    University of Bristol, UK
  • MSC, THE NATIONAL UNIVERSITY OF SINGAPORE, SINGAPORE (1999), (Sains)
    Singapore University, Singapore
  • BSC (AGRICULTURE), NATIONAL TAIWAN UNIVERSITY, TAIWAN (1995), (Agriculture)
    National Taiwan University, Taipei

MEMBERSHIPS

  • PRESIDENT OF THE NASOPHARYNGEAL CARCINOMA SOCIETY OF MALAYSIA, PRESIDENT/ CHIEF
    2023 to 2024 (National)
  • ASSOCIATION OF UNION FOR INTERNATIONAL CANCER CONTROL (UICC) FELLOWS, MEMBER
    Since 2011 (International)
  • NASOPHARYNGEAL CARCINOMA SOCIETY OF MALAYSIA (PRESIDENT), PRESIDENT/ CHIEF
    2021 to 2022 (National)
  • NASOPHARYNGEAL CARCINOMA SOCIETY OF MALAYSIA (PRESIDENT), PRESIDENT/ CHIEF
    2020 to 2021 (National)
  • NASOPHARYNGEAL CARCINOMA SOCIETY OF MALAYSIA (PRESIDENT), PRESIDENT/ CHIEF
    2019 to 2020 (National)
  • NASOPHARYNGEAL CARCINOMA SOCIETY OF MALAYSIA (VICE PRESIDENT), VICE PRESIDENT
    2018 to 2019 (National)
  • NASOPHARYNGEAL CARCINOMA SOCIETY OF MALAYSIA (CHAIRPERSON FOR 7TH NPC RESEARCH DAY), ORGANISING CHAIRPERSON
    2017 to 2018 (National)
  • UNIVERSITY OF BIRMINGHAM UK, HONORARY FELLOW
    2010 to 2015 (International)
  • AMERICAN ASSOCIATION FOR CANCER RESEARCH, ACTIVE MEMBER
    2009 to 2013 (International)

AWARD AND STEWARDSHIP

  • UICC Yamagiwa-Yoshida Memorial International Cancer (YY) Study Grant
    UICC, 2024 (International)
  • Erasmus+ staff mobility training award
    University of Limerick, 2023 (International)
  • Singapore Immunology Network and Standard BioTools Greater Asia High-Dimensional Immune Profiling Research Award 2022
    Standard Biotools, 2022 (International)
  • COGEN INSIGHTS GRANT AWARD
    Codon Genomics, 2021 (National)
  • Expert panel on medical, science and technology field (100th Anniversary of Chong Hwa High School)
    Ching Hwa Independent High School, 2019 (Private)
  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2018 (University)
  • Newton-Ungku Omar Fund - UK-Malaysia Bilateral Health Research Collaboration Programme
    Academy of Science Malaysia and Medical Research Council UK, 2017 (International)
  • International Fellowship for Young Scientist Forum at OzBio 2010 Conference, Australia
    OzBio 2010 Conference Committee, 2010 (International)
  • America Cancer Society International Fellowship for Beginning Investigators
    Union for International Cancer Control (UICC), 2010 (International)
  • Scholar-in-Training Award (AACR)
    American Association for Cancer Research (AACR)-ITO EN, Ltd., 2008 (International)

PUBLICATIONS

Article in Journal
WoS
  1. Leu, K. F.; Menaga, Subramaniam; Wang, Xinghua; Yang, Z.; Yap, Lee Fah; Lo, K. Wai; Lim, Yang Mooi (2023). A Global Gene Expression Study on Xiao Xian Xiong Decoction-Treated Hone-1, INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES. 85(5), 1485-1503
  2. Gokulan, Ravindran Caspa; Yap, Lee Fah; Paterson, Ian C. (2022). HOPX: A Unique Homeodomain Protein in Development and Tumor Suppression, CANCERS. 14(11). doi:10.3390/cancers14112764
  3. Yap, Lee Fah; Wong, Anna Kang Chee; Paterson, Ian C.; Young, Lawrence S. (2022). Functional Implications of Epstein-Barr Virus Lytic Genes in Carcinogenesis, CANCERS. 14(23). doi:10.3390/cancers14235780
Others
  1. Bruce JP, To KF, Lui VWY, Chung GTY, Chan YY, Tsang CM, Yip KY, Ma BBY, Woo JKS, Hui EP, Mak MKF, Lee SD, Chow C, Velapasamy S, Or YYY, Siu PK, El Ghamrasni S, Prokopec S, Wu M, Kwan JSH, Liu Y, Chan JYK, C. van Hasselt CA, Young LS, Dawson CW, Paterson IC, Yap LF, Tsao SW, Liu FF, Chan ATC, Pugh TJ, Lo KW. Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF- B activation and immune escape. Nature Communications 2021 Jul 7;12(1):4193. doi: 10.1038/s41467-021-24348-6. (IF: 17.694)
  2. K.E. Tan, W.L. Ng, G.K. Marinov, K.H. Yu, L.P. Tan, E.S. Liau, S.Y. Goh, K.S. Yeo, K.Y. Yip, K.W. Lo, A.S. Khoo, L.F. Yap, C.K. Ea, YY Lim. Identification and characterization of a novel Epstein-Barr Virus-encoded circular RNA from LMP-2 Gene. Scientific Reports. 2021; 11: 14392. (IF: 4.997)
  3. M.L. Tan, E.K. Parkinson, L.F. Yap, I.C. Paterson. Autophagy is deregulated in cancer associated fibroblasts from oral cancer and is stimulated during the induction of fibroblast senescence by TGF 1. Scientific Reports. 2021; 11: 584. (IF: 4.997)
  4. Abdul Rahman M, Mohamad Haron DE, Hollows RJ, Abdul Ghani ZDF, Ali Mohd M, Chai WL, Ng CC, Lye MS, Karsani SA, Yap LF, Paterson IC. 2020. Profiling lysophosphatidic acid levels in plasma from head and neck cancer patients. PeerJ 8:e9304 https://doi.org/10.7717/peerj.9304
  5. H. Wu, Y. Sun, W.L. Wong, J. Cui, J. Li, X. You, L.F. Yap, Y. Huang, W. Hong, X. Yang, I. Paterson, H. Wang. The development of a novel transforming growth factor- (TGF- ) inhibitor that disrupts ligand-receptor interactions. European Journal of Medicinal Chemistry 2020; 189:112042.
  6. H.M. Lee, A.P.E. Sia, L. Li, H.P. Sathasivam, M.S.A. Chan, P. Rajadurai, C.M. Tsang, S.W. Tsao, P.G. Murray, Q. Tao, I.C. Paterson, L.F. Yap. Monoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma. Scientific Reports. 2020; 10(1):6115.
  7. M.A. Rahman, M.L. Tan, S.P. Johnson, R.J. Hollows, W.L. Chai, J.P. Mansell, L.F. Yap, I.C. Paterson. Deregulation of lysophosphatidic acid metabolism in oral cancer promotes cell migration via the up-regulation of COX-2. Peer J. 2020; 8: e10328.
  8. Lai S.L., Tan, M.L., Hollows, R.J., Robinson, M., Ibrahim, M., Margielewska, S., Parkinson E.K., Ramanathan, A., Zain, R., Mehanna, H., Spruce, R.J., Wei, W., Chung, I., Murray, P.G., Yap, L.F., Paterson, I.C. (2019). Collagen induces a more proliferative, migratory and chemoresistant phenotype in head and neck cancer via DDR1. Cancers, 11(11): 1766.
  9. San Jiun Chai, Muhammad Mamduh Ahmad Zabidi, Siew Pey Gan, Pathmanathan Rajadurai, Paul Vey Hong Lim, Ching Ching Ng, Lee Fah Yap, Soo Hwang Teo, Kue Peng Lim, Vyomesh Patel, Sok Ching Cheong. An oncogenic role for Four-jointed Box 1 (FJX1) in nasopharyngeal carcinoma. Disease Markers. 2019:3857853.
  10. L.F. Yap, S.L. Lai, A. Rhodes, H.P. Sathasivam, M.A. Abdullah, K.C. Pua, P. Rajadurai, P.L. Cheah, S. Thavaraj, M. Robinson and I. C. Paterson. Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection. Infectious Agents and Cancer. 2018; 13: 21.
  11. Raymond W-M Lung, Pok-Man Hau, Ken H-O Yu, Kevin Y. Yip,Joanna H-M Tong, W-P Chak, Anthony W-H Chan, Ka-Hei Lam, Angela K-F Lo, Edith K-Y Tin, Shuk-Ling Chau, Jesse C-S Pang, Johnny S-H Kwan, Pierre Busson, Lawrence S. Young, Lee-Fah Yap, Sai-Wah Tsao, Ka-Fai To, Kwok-Wai Lo. (2018) EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma. The Journal of Pathology. 244(4):394-407
  12. S. Velapasamy, C.W. Dawson, L.S. Young, I.C. Paterson and L.F. Yap. The dynamic roles of TGF- signalling in EBV-associated cancers. Cancers. 2018; 10(8): 247.
  13. H.M. Lee, K.W. Lo, W. Wei, S.W. Tsao, G.T. Chung, M.H. Ibrahim, C.W. Dawson, P.G. Murray, I.C. Paterson and L.F. Yap. Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3. Journal of Pathology. 2017 Feb 27. doi: 10.1002/path.4879. (Impact factor: 7.381)
  14. S.N. Patmanathan, W. Wang, L.F. Yap, D.R. Herr and I.C. Paterson. Mechanisms of sphingosine 1-phosphate receptor signalling in cancer. Cellular Signalling. 2017; 34: 66-75. (Impact factor: 4.191)
  15. J.S. Low, Y.M. Chin, T. Mushiroda, M. Kubo, G.K. Govindasamy, K.C. Pua, Y.Y. Yap, L.F. Yap, S.K. Subramaniam, C.A. Ong, T.Y. Tan, A.S.B. Khoo, The Malaysian NPC Study Group, C.C. Ng. A genome wide study of copy number variation associated with nasopharyngeal carcinoma in Malaysian Chinese identifies CNVs at 11q14.3 and 6p21.3 as candidate loci. Plos One. 2016; 11: e0145774. (Impact factor: 3.057)
  16. L.F. Yap, S.L. Lai, S.N. Patmanathan, R. Gokulan, C.M. Robinson, J.B. White, S.J. Chai, P. Rajadurai, N. Prepageran, Y.T. Liew, V. Lopes, W. Wei, R.J. Hollows, P.G. Murray, D.W. Lambert, K.D. Hunter, I.C. Paterson. HOPX functions as a tumour suppressor in head and neck cancer. Scientific Reports. 2016; 6:38758. (Impact factor: 5.228)
  17. L.S. Young, L.F. Yap and P.G. Murray. Epstein-Barr Virus: over 50 years and still providing surprises. Nature Reviews Cancer. 2016; 16: 789-802. (Impact factor: 34.244)
  18. M.A. Morris, C.W. Dawson, L. Laverick, A.M. Lock, J.P.R. Dudman, S. Raveethiraraj, Z. Ahmad, L.F. Yap and L.S. Young. The Epstein-Barr virus encoded LMP1 oncoprotein modulates cell adhesion via regulation of activin A/TGFbeta and beta-1 integrin signalling. Scientific Reports. 2016; 6:19533. (Impact factor: 5.228)
  19. S.N. Patmanathan, S.P. Johnson, S.L. Lai, S. Panja Bernam, V. Lopes, W. Wei, M.H. Ibrahim, F. Torta, P. Narayanaswamy, M.R. Wenk, D.R. Herr, P.G. Murray, L.F. Yap, Paterson IC. Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2. Scientific Reports. 2016; 6:25650 (Impact factor: 5.228)
  20. H. Taha, C.Y. Looi, A. Arya, W.F. Wong, L.F. Yap, M. Hasanpourghadi, A.M. Mustafa, I.C. Paterson, H.M. Ali. (6E,10E) Isopolycerasoidol and (6E,10E) Isopolycerasoidol methyl ester, prenylated benzopyran derivatives from Pseuduvaria monticola induce mitochondrial-mediated apoptosis in human breast adenocarcinoma cells. Plos One. 2015; 10: e0126126. (Impact factor: 3.057)
  21. L.F. Yap, D. Lee, A.N.M. Khairuddin, M.F. Pairan, B. Puspita, C.H. Siar and I.C. Paterson. The opposing roles of NOTCH signalling in head and neck cancer: a mini review. Oral Diseases. 2015; 21: 850- 857.
  22. L.F. Yap, S. Velapasamy, H.M. Lee, S. Thavaraj, R. Pathmanathan, W. Wei, K. Vrzalikova, M.H. Ibrahim, A. Khoo, S.W. Tsao, I.C. Paterson, G.S. Taylor, C.W. Dawson and P.G. Murray. Down-regulation of LPA receptor 5 to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma. Journal of Pathology; 235: 456-465 (Impact factor: 7.381)
  23. M. Vockerodt, L.F. Yap, C. Shannon-Lowe, H. Curley, W. Wei, K. Vrzalikova, P.G. Murray. The Epstein- Barr virus and the pathogenesis of lymphoma. Journal of Pathology. 2015; 235: 312-322. (Impact factor: 7.381)
  24. S.J. Chai, Y.Y. Yap, Y.C. Foo, L.F. Yap, S. Ponniah, S.H. Teo, S.C. Cheong, V. Patel, K.P Lim. Identification of four-jointed box 1 (FJX1)-specific peptides for immunotherapy of nasopharyngeal carcinoma. Plos One. 2015; 10: e0130464. (Impact factor: 3.057)
  25. S.N. Patmanathan, L.F. Yap, P.G. Murray and I.C. Paterson. The antineoplastic properties of FTY720: Evidence for the repurposing of fingolimod. Journal of Cellular and Molecular Medicine. 2015; 19: 2329- 2340. (Impact factor: 4.938)
  26. W. Hong, Y. Wang, Z. Chang, Y. Yang, J. Pu, T. Sun, S. Kaur, J.C. Sacchettini, H. Jung, W.L. Wong, L.F. Yap, Y.F. Ngeow, I.C. Paterson, H. Wang. The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling. Scientific Reports. 2015; 5: 15328. (Impact factor: 5.228)
  27. G. Mohamed, K. Vrzalikova, Z. Cader, M. Vockerodt, E. Nagy, P. Flodr, L.F. Yap, A. Diepstra, P. Kluin, S. Rosati, P. Murray. Epstein-Barr Virus, the germinal centre and the development of Hodgkin's Lymphoma. Journal of General Virology. 2014; 95: 1861-1869. (Impact factor: 3.192)
  28. L.F. Yap, M. Ahmad, M.M. Zabidi, T.L. Chu, S.J. Chai, H.M. Lee, P.V. Lim, W. Wei, C. Dawson, S.H. Teo and A.S. Khoo. Oncogenic effects of WNT5A in Epstein-Barr Virus-associated nasopharyngeal carcinoma. International Journal of Oncology. 2014; 44: 1774- 1780. (Impact factor: 3.018)
  29. W. Hong, J. Li, C.A. Laughton, L.F. Yap, I.C. Paterson, H. Wang. Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling. Journal of Molecular Graphics and Modelling. 2014; 51: 193-202. (Impact factor: 1.674)
  30. Y.M. Chin, T. Mushiroda, A. Takahashi, M. Kubo, G. Krishnan, L.F. Yap, S. Teo, P.V.H. Lim, Y.Y. Yap, K.C. Pua, N. Kamatani, Y. Nakamura, C.K. Sam, A.S. Khoo, The Malaysian NPC Study Group and C.C. Ng. HLA-A SNPs and amino acid variants are associated with nasopharyngeal carcinoma in Malaysian Chinese. International Journal of Cancer. 2015; 136: 678-687. (Impact factor: 5.531)
  31. P.Y. Yew, T. Mushiroda, K. Kiyotani, G. Krishnan, L.F. Yap, S. Teo, P.V.H. Lim, S. Govindaraju, K. Ratnavelu, C.K Sam, Y.Y. Yap, A.S.B. Khoo, K.C Pua, Y. Nakamura, The Malaysian NPC Study Group, C.C Ng. Identification of a functional variant in SPLUNC1 associated with nasopharyngeal carcinoma susceptibility among Malaysian Chinese. Molecular Carcinogenesis. 2011; 51: E74-82. (Impact factor: 4.722)
  32. S.J. Chai, K.C. Pua, A. Saleh, Y.Y. Yap, S.K. Subramaniam, C.L. Lum, G. Gopala Krishnan, the Malaysian NPC Study Group, A.S.B. Khoo and L.F. Yap.2012. Clinical Significance of Plasma EBV DNA Loads in the Largest Cohort of Malaysian Patients with Nasopharyngeal Carcinoma. Journal of Clinical Virology. 2012; 55: 34-39. (Impact factor: 2.647)
  33. C.C. Ng, P.Y. Yew, S.M. Puah, G. Krishnan, L.F. Yap, S.H. Teo, P.V.H. Lim, S. Govindaraju, K. Katnavelu, C.K. Sam, A. Takahashi, M. Kubo, N. Kamatani, Y. Nakamura and T. Mushirod. A genome-wide association study identifies ITGA9 conferring risk of nasopharyngeal carcinoma. Journal of Human Genetics. 2009; 54: 392-397.
  34. L.F. Yap, V. Jenei, C.M. Robinson, T.M. Benn, K. Moutasim, S.P. Threadgold, V. Lopes, W. Wei, G.J. Thomas, I.C. Paterson. Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation. Oncogene. 2009; 28: 2524-2534. (Impact factor: 7.932)
  35. S. Bose*, L.F. Yap*, M. Fung, J. Starzcynski, A.Saleh, S. Morgan, C.W. Dawson, M.B. Chukwuma, E. Maina, Buettner M, W. Wei, J. Arrand, , P.V.H. Lim, L.S. Young, S.H. Teo, T. Stankovic, C.B.J. Woodman and P.G. Murray. The ATM tumor suppressor gene is downregulated in EBV-associated nasopharyngeal carcinoma. Journal of Pathology. 2009; 217: 345-352. (*Equal contribution) (Impact factor: 7.381)
  36. K.C. Pua, A.S.B. Khoo, Y.Y. Yap, S.K. Subramaniam, C.A. Ong, G. Gopala Krishnan, H. Shahid, The Malaysian Nasopharyngeal Study Group. Nasopharyngeal carcinoma database. Medical Journal of Malaysia. 2008; 63: 59- 62.
  37. K.R.N. Baumforth, A. Birgersdotter, G.M. Reynolds, W. Wei, G. Kapatai, J.R. Flavell, E. Kalk, K. Piper, S. Lee, L. Machado, K. Hadley, A. Sundblad, J. Sjoberg, M. Bjorkholm, A.A. Porwit, L.F. Yap, S. Teo, R.G. Grundy, L.S. Young, I. Ernberg, C.B.J. Woodman and P.G. Murray. Expression of the Epstein-Barr virus-encoded Epstein-Barr virus nuclear antigen 1 in Hodgkin's lymphoma cells mediates up-regulation of CCL20 and the migration of regulatory T cells. American Journal of Pathology. 2008; 173: 195-204. (Impact factor: 4.206)
  38. E. Thirthagiri, C.M. Robinson, S. Huntley, M. Davies, L.F. Yap, S.S. Prime and I.C. Paterson. Spindle assembly checkpoint and centrosome abnormalities in oral cancer. Cancer Letters. 2007; 258: 276-285. (Impact factor: 5.992)
  39. L.F. Yap, S. Low, W. Liu and J. Kwang. Detection and screening of Salmonella enteritidis-infected chickens with recombinant flagellin. Avian Disease. 2001; 45: 410-415. (Impact factor: 1.104)
  40. L.F. Yap, Y.K. Lee and C.L. Poh. Mechanism for phenol tolerance in phenol-degrading Comamonas testosteroni strain. Applied Microbiology and Biotechnology. 1999; 51: 833-840. (Impact factor: 3.376)
Chapter in Books
  1. Yap, L.F., & Lo, K.W. (2018). Chapter 7: Epstein-Barr virus and epithelial carcinogenesis. In S. Roberts (Eds.), DNA tumour viruses: Virology, Pathogenesis and Vaccines. Caister Academic Press.

RESEARCH INTEREST

  • Defining key molecular changes that result in normal cells to transforming into cancerous cells using high-throughput genome-wide technologies and functional studies (gene expression, functional studies)
  • Elucidating the contribution of Epstein-Barr virus infection to the development of nasopharyngeal carcinoma (NPC) (Epstein-Barr virus, nasopharyngeal carcinoma (NPC))
  • Understanding the suppressive role of NPC tumour microenvironment (tumour microenvironment)

RESEARCH PROJECT

National
  1. 2023 - 2026, Fundamental Research Grant Scheme (FRGS)
    Analysis Of Molecular Alterations In Ras-mapk Pathway In Ameloblastoma And The Role Of Adp-ribosylation Factor Like-4c (arl4c) As A Novel Predictive Indicator Of Recurrence ( Co-Researcher)
  2. 2022 - 2025, Fundamental Research Grant Scheme (FRGS)
    Elucidating The Functional Role of Cancer-Associated Fibroblasts And Macrophages From Nasopharyngeal Carcinoma ( Co-Researcher)
  3. 2020 - 2023, Others MOHE - Top 100 (IIRG)-FNW
    Top-down: Characterisation Of Tumours From Chineseand Sarawak Native Patients With Nasopharyngeal Carcinoma ( Principal Investigator(PI))
  4. 2019 - 2022, Fundamental Research Grant Scheme (FRGS)
    The Role Of Sphingosine 1-phosphate Signalling In Mediating Cross-talk Between Tumour Cells And Fibroblasts In Oral Cancer ( Co-Researcher)
  5. 2019 - 2022, Fundamental Research Grant Scheme (FRGS)
    Elucidating The Functional Significance Of Epstein-barr Virus Lytic Genes In Nasopharyngeal Carcinoma ( Principal Investigator(PI))
  6. 2017 - 2020, Fundamental Research Grant Scheme (FRGS)
    Mechanistic Insight Into The Role Of Epstein-barr Virus-encoded Circrna (circlmp2) In The Development And Progression Of Nasopharyngeal Carcinoma. ( Co-Researcher)
  7. 2017 - 2020, UM Grant - Frontier Research Grant
    Dissecting The Role Of Autophagy And Senescence In Mediating The Tumour Promoting Effects Of Cancer-associated Fibroblasts From Oral Squamous Cell Carcinoma ( Co-Researcher)
  8. 2016 - 2018, Fundamental Research Grant Scheme (FRGS)
    Contribution Of Epstein-barr Virus (ebv) To The Gene Expression Programme Of Nasopharyngeal Carcinoma ( Principal Investigator(PI))
  9. 2017 - 2018, Partnership Grant
    Elucidating The Intrinsic And Extrinsic Factors That Affect Anti-tumor T Cell Responces In Nasopharyngeal Carcinoma ( Principal Investigator(PI))
  10. 2016 - 2017, Bantuan Khas Penyelidikan (BKP Special)
    Targeting Sphingosine Kinases: A Novel Therapy For Oral Cancer ( Co-Researcher)
  11. 2013 - 2016, High Impact Research - Ministry of Education (HIR-MOE) Cycle 3
    Programme Title: Oncogenesis Of Head And Neck Cancer: Initiation, Progression And Heterogeneity Project Title: Contribution Of Epstein-barr Virus, Cellular Signalling Pathways And Driver Mutations To The Pathogenesis Of Nasopharyngeal Carcinoma. ( Principal Investigator(PI))
  12. 2012 - 2015, Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness)
    Stromal Fibroblasts As Mediators Of Chemoresistance In Oral Carcinoma Cells ( Co-Researcher)
  13. 2012 - 2015, Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness)
    The Notch Signalling Pathway And Treatment Resistance In Head And Neck Cancer ( Principal Investigator(PI))
  14. 2013 - 2015, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness)
    Cell Signaling Molecules As Potential Biomakers And Therapeutic Targets For Oscc ( Principal Investigator(PI))
International
  1. 2017 - 2021, International Funding
    Investigating Anti-tumor T Cell Responses In Nasopharyngeal Carcinoma To Refine Vaccine-based ( Principal Investigator(PI))

PAPER PRESENTED

INVITED SPEAKER
  1. Insights into transcriptomic profiling of EBV-associated nasopharyngeal carcinoma, Malaysia Next Generation Sequencing Symposium 2022, Next Gene Scientific Sdn. Bhd. (National) (14 Sep 2022 - 15 Sep 2022)
  2. New insights into NPC genomics, Nasopharyngeal Carcinoma Gordon Research Conference, Gordon Research Conference (International) (08 May 2022 - 13 May 2022)
  3. Transcriptional profiles of EBV-associated nasopharyngeal carcinoma, UniSZA International Webinar-Symposium On The -Omics Revolution In Medicine And Health Sciences , UniSZA (International) (07 Dec 2021 - 08 Dec 2021)
  4. Nasopharyngeal Carcinoma: Understand the role of Epstein-Barr Virus , Bridging Translational Cancer Research Forum, University of Malaya Cancer Research Institute (University) (03 Mar 2020 - 03 Mar 2020)
  5. Epstein-Barr Virus and Nasopharyngeal Carcinoma, 1st Malaysian Association For Cancer Research (MACR) Scientific Conference, Malaysian Association for Cancer Research (International) (03 Dec 2019 - 04 Dec 2019)
  6. EBV infection: role in the pathogenesis of NPC, 8th Nasopharyngeal Carcinoma (NPC) Research Day, Nasopharyngeal Carcinoma Society of Malaysia (International) (27 Mar 2019 - 27 Mar 2019)
  7. Potential Biomarkers and Novel Therapies for Nasopharyngeal Carcinoma, 2nd AMDI International Oncology & Medical Physics Symposium, Universiti Sains Malaysia (International) (01 Mar 2019 - 03 Mar 2019)
  8. How Does EBV Infects Nasopharyngeal Epithelium, Nasopharyngeal Cancer Workshop, The HEAD Foundation Singapore (International) (25 Jan 2019 - 26 Jan 2019)
  9. Nasopharyngeal carcinoma (NPC): Regulation of persistent Epstein-Barr virus (EBV) infection, THE INTERNATIONAL SYMPOSIUM ON CANCER BIOLOGY: Opportunities for Research, UNIVERSITAS GADJAH MADA (International) (24 Aug 2018 - 25 Aug 2018)
  10. EBV infection and nasopharyngeal carcinoma (NPC): what we know so far? , Cancer Research Conference 2017, Universiti Tunku Abdul Rahman (International) (29 Nov 2017 - 30 Nov 2017)
  11. Sphingosine-1-phosphate (S1P) signalling: an opportunity for targeted therapy in NPC? , The CANCER 2017 Meeting - The 13th Asia Pacific Multidisciplinary Meeting for Cancer Research, The Chinese University of Hong Kong (International) (22 Jun 2017 - 22 Jun 2017)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2023) Functional significance of Epstein-Barr, ANNA KANG CHEE WONG
  2. (2015) MECHANISMS AND THERAPEUTIC POTENTIAL OF SPHINGOSINE-1-PHOSPATE SINGNALLING IN ORAL SQUAMOUS CELL CARCINOMA, SATHYA NARAYANAN A/L PATMANATHAN
  3. (2014) Senescence and autophagy in cancer-associated fibroblasts of oral squamous cell carcinoma, Tan May Leng
  4. (2013) Transforming growth factor-beta signalling in the regulation of EBV infection in nasopharyngeal epithelial cells, Sharmila A/P Velapasamy
  5. (2013) Collagen-DDR1 Signaling in HPV-positive and - Negative Head and Neck Cancer, Lai Sook Ling
  6. (2012) Mechanisms and therapeutic potential of sphingosine-1-phosphate signalling in oral squamous cell carcinoma, Sathya Narayanan Patmanathan
  7. (2012) Investigation into the roles of lysophosphatidic acid (LPA) in the pathogenesis of head and neck cancer, Mariati binti Abdul Rahman
  8. (2012) Aberrant activation of sphingosine-1-phosphate signalling in nasopharyngeal carcinoma, Lee Hui Min
Master
  1. (2023) CONTRIBUTION OF EPSTEIN-BARR VIRUS TO THE GENE EXPRESSION PROGRAMME OF NASOPHARYNGEAL CARCINOMA, CHAN SUAT MING
  2. (2023) THE ROLE OF SPHINGOSINE 1-PHOSPHATE SIGNALLING IN MEDIATING FIBROBLASTS ACTIVATION IN HEAD AND NECK CANCER, KATHYLEEN HUI LIN CHONG
  3. (2019) FUNCTIONAL CHARACTERISATION OF CANCER ASSOCIATED FIBROBLASTS FROM NASOPHARYNGEAL CARCINOMA, WONG WEE LIN
  4. (2018) Transcriptomic analysis of the role of circular RNA LMP2 in EBV-free and EBV-infected cells, TAN KE EN
  5. (2015) Determine the viral activities of Epstein-Barr virus in association with the development of nasopharyngeal carcinoma, Lee Boon Kiat (000000335)
  6. (2015) Determine the oncogenic activity of different Epstein-Barr virus proteins on the development of nasopharyngeal cancer, Kong Ee Ling (000000335)
  7. (2011) Longitudinal measurement of health-related quality of life and overall survival among nasopharyngeal cancer patients treated with or without neoadjuvant chemotherapy in Sabah, Malaysia, Liew Yew Toong

SOCIAL RESPONSIBILITY ACTIVITIES

  • Organising Committee for Npc Showcase and Exhibition Booth At The World Cancer Day 2024, (17 Feb 2024 - 17 Feb 2024) (National)
  • Organising Committee Member for Npc Educational Booth Exhibition At The Mos Cancer Survivorship Forum, (04 Feb 2024 - 04 Feb 2024) (National)
  • Organising Committee Member for Mouth Cancer Awareness Month 2024, (04 Feb 2024 - 04 Feb 2024) (National)
  • Organising Committee Member for Npc Awareness Day, (11 Nov 2023 - 11 Nov 2023) (National)
  • Moderator in a Public Webinar, (13 Nov 2022 - 13 Nov 2022) (National)
  • Academic Advisory Committee Member of a High School, (24 Sep 2022 - 31 Dec 2025) (National)
  • Trainer of An Upskill Program for School Teachers, (27 Aug 2022 - 27 Aug 2022) (National)
  • Exhibition At The World Cancer Day 2020, (04 Feb 2020 - 04 Feb 2020) (National)
  • Expert Panel for a Sharing Session At a High School, (07 Sep 2019 - 07 Sep 2019) (National)
  • Expert Panel for Nose Cancer Survivor Support Group, (17 Aug 2019 - 17 Aug 2019)
  • Distinguished Alumni (Chong Hwa Independent High School) Interview, (16 Nov 2018 - 21 Mar 2019)
  • Expert Interview by Sin Chew Press, (26 Oct 2018 - 08 Jan 2019)
  • Invited Speaker At Ningxia Medical University, China, (20 Oct 2014 - 20 Oct 2014)
  • Foreigner Expert Invitation Program (China), (14 Oct 2014 - 21 Oct 2014)