Curriculum Vitae

ASSOCIATE PROF. DR. WONG WON FEN

Associate Professor
  • Department of Medical Microbiology
    Faculty of Medicine
  • 0379676672

AREAS OF EXPERTISE

  • CELLULAR IMMUNOLOGY
    Lymphocytes development and activation, Immunity to pathogens

ACADEMIC QUALIFICATION

  • PHD (LIFE SCIENCES), (Life Sciences)
    Tohoku University, Japan
  • MASTER OF LIFE SCIENCES, (Life Sciences)
    Tohoku University, Japan
  • BSC,PASS WITH HONOURS (WITH DISTINTION), GENETICS & MOLECULAR BIOLOGY, (Science)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • Committee Members
    01 Jun 2022 - 31 May 2024 (Faculty)
  • Quality Manager
    01 Jan 2019 - 01 Jun 2021 (Department of Medical Microbiology, Faculty of Medicine)
  • ADHOC COMMITTEE POSTGRADUATE PROPOSAL
    01 Jan 2019 - 31 Dec 2019 (Department of Medical Microbiology, Faculty of Medicine)
  • COMMITTEE SEBUT HARGA
    01 Jan 2019 - 31 Dec 2019 (Department of Medical Microbiology, Faculty of Medicine)
  • Quality Manager
    30 Sep 2016 - 29 Sep 2018 (Department of Medical Microbiology, Faculty of Medicine)
  • Programme Coordinator
    01 Sep 2016 - 01 Sep 2018 (Department of Medical Microbiology, Faculty of Medicine)
  • Panel reviewer
    15 Aug 2016 - 30 Aug 2018 (Department of Medical Microbiology, Faculty of Medicine)
  • COMMITTEE - Sebut Harga
    20 Nov 2017 - 21 Nov 2017 (Department of Medical Microbiology, Faculty of Medicine)
  • Ad-Hoc Committee
    01 Jan 2016 - 31 Dec 2016 (Department of Medical Microbiology, Faculty of Medicine)

MEMBERSHIPS

  • MALAYSIAN SOCIETY OF INFECTIOUS DISEASES AND CHEMOTHERAPY (MSIDC), ACTIVE MEMBER
    2017 to 2022 (University)
  • MALAYSIAN SOCIETY OF INFECTIOUS DISEASES AND CHEMOTHERAPY (MSIDC), MEMBER
    2017 to 2019 (National)

AWARD AND STEWARDSHIP

  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2019 (University)
  • Fulbright Visiting Scholar
    U.S. Secretary of State, 2018 (International)
  • Year 2017 Science and Technology Fund
    Malaysia Toray Science Foundation, 2017 (National)
  • Yong Investigator Award
    Institut Merieux - MSIDC, 2017 (International)
  • Malaysia Toray Research Grant
    Malaysia Toray Science Foundation, 2015 (National)
  • JSPS Fellowship
    Japan Society for the Promotion of Science, 2010 (International)
  • Monbukagakusho (MEXT) Scholarship
    Japanese Govenment Ministry of Education, Culture, Sports, Science and Technology, 2004 (International)

PUBLICATIONS

Article in Journal
WoS
  1. Chan, Yee Teng; Cheok, Yi Ying; Cheong, Heng Choon; Tan, Grace Min Yi; Seow, Shi Rui; Tang, Ting Fang; Sulaiman, Sofiah; Looi, Chung Yeng; Gupta, Rishein; Arulanandam, Bernard; Wong, Won Fen (2023). Influx of podoplanin-expressing inflammatory macrophages into the genital tract following Chlamydia infection, IMMUNOLOGY AND CELL BIOLOGY. 101(4), 305-320. doi:10.1111/imcb.12621
  2. Chan, Yee Teng; Cheok, Yi Ying; Cheong, Heng Choon; Tang, Ting Fang; Sulaiman, Sofiah; Hassan, Jamiyah; Looi, Chung Yeng; Tan, Kim-Kee; AbuBakar, Sazaly; Wong, Won Fen (2023). Immune Recognition versus Immune Evasion Systems in Zika Virus Infection, BIOMEDICINES. 11(2). doi:10.3390/biomedicines11020642
  3. Cheong, Heng Choon; Cheok, Yi Ying; Chan, Yee Teng; Tang, Ting Fang; Sulaiman, Sofiah; Looi, Chung Yeng; Gupta, Rishein; Arulanandam, Bernard; Chang, Li-Yen; Wong, Won Fen (2023). Chlamydia trachomatis plasmid-encoding Pgp3 protein induces secretion of distinct inflammatory signatures from HeLa cervical epithelial cells, BMC MICROBIOLOGY. 23(1). doi:10.1186/s12866-023-02802-3
  4. Cheong, Heng Choon; Sulaiman, Sofiah; Looi, Chung Yeng; Chang, Li-Yen; Wong, Won Fen (2023). Chlamydia Infection Remodels Host Cell Mitochondria to Alter Energy Metabolism and Subvert Apoptosis, MICROORGANISMS. 11(6). doi:10.3390/microorganisms11061382
  5. Chan, Yee Teng; Cheong, Heng Choon; Tang, Ting Fang; Rajasuriar, Reena; Cheng, Kian-Kai; Looi, Chung Yeng; Wong, Won Fen; Kamarulzaman, Adeeba (2022). Immune Checkpoint Molecules and Glucose Metabolism in HIV-Induced T Cell Exhaustion, BIOMEDICINES. 10(11). doi:10.3390/biomedicines10112809
  6. Cheok, Yi Ying; Tan, Grace Min Yi; Fernandez, Keith Conrad; Chan, Yee Teng; Lee, Chalystha Yie Qin; Cheong, Heng Choon; Looi, Chung Yeng; Vadivelu, Jamuna; Abdullah, Suhailah; Wong, Won Fen (2022). Podoplanin Drives Motility of Active Macrophage via Regulating Filamin C During Helicobacter pylori Infection (vol 12, 702156, 2021), FRONTIERS IN IMMUNOLOGY. 13. doi:10.3389/fimmu.2022.857795
  7. Cheok, Yi Ying; Tan, Grace Min Yi; Lee, Chalystha Yie Qin; Abdullah, Suhailah; Looi, Chung Yeng; Wong, Won Fen (2022). Innate Immunity Crosstalk with Helicobacter pylori: Pattern Recognition Receptors and Cellular Responses, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23(14). doi:10.3390/ijms23147561
  8. Cheong, Heng Choon; Cheok, Yi Ying; Chan, Yee Teng; Sulaiman, Sofiah; Looi, Chung Yeng; Alshanon, Ahmed F.; Hassan, Jamiyah; Abubakar, Sazaly; Wong, Won Fen (2022). Zika Virus Vaccine: The Current State of Affairs and Challenges Posed by Antibody-Dependent Enhancement Reaction, VIRAL IMMUNOLOGY. . doi:10.1089/vim.2022.0082
  9. Lee, Chalystha Yie Qin; Chan, Yee Teng; Cheok, Yi Ying; Tan, Grace Min Yi; Tang, Ting Fang; Cheong, Heng Choon; Vadivelu, Jamuna; Abdullah, Suhailah; Looi, Chung Yeng; Wong, Won Fen (2022). Helicobacter pylori Infection Elicits Type I Interferon Response in Human Monocytes via Toll-Like Receptor 8 Signaling, JOURNAL OF IMMUNOLOGY RESEARCH. 2022. doi:10.1155/2022/3861518
  10. Tang, Ting Fang; Chan, Yee Teng; Cheong, Heng Choon; Cheok, Yi Ying; Anuar, Nur Adila; Looi, Chung Yeng; Gan, Gin Gin; Wong, Won Fen (2022). Regulatory network of BLIMP1, IRF4, and XBP1 triad in plasmacytic differentiation and multiple myeloma pathogenesis, CELLULAR IMMUNOLOGY. 380. doi:10.1016/j.cellimm.2022.104594
  11. Yong, Yean Kong; Wong, Won Fen; Vignesh, Ramachandran; Chattopadhyay, Indranil; Velu, Vijayakumar; Tan, Hong Yien; Zhang, Ying; Larsson, Marie; Shankar, Esaki M. (2022). Dengue Infection-Recent Advances in Disease Pathogenesis in the Era of COVID-19, FRONTIERS IN IMMUNOLOGY. 13. doi:10.3389/fimmu.2022.889196
  12. Cheok, Yi Ying; Lee, Chalystha Yie Qin; Cheong, Heng Choon; Vadivelu, Jamuna; Looi, Chung Yeng; Abdullah, Suhailah; Wong, Won Fen (2021). An Overview of Helicobacter pylori Survival Tactics in the Hostile Human Stomach Environment, MICROORGANISMS. 9(12). doi:10.3390/microorganisms9122502
Others
  1. Cheok YY, Lee CYQ, Cheong HC, Looi CY, Wong WF. (2020) Chronic Inflammatory Diseases at Secondary Sites Ensuing Urogenital or Pulmonary Chlamydia Infections. Microorganisms. 2020 Jan 17;8(1):127. doi: 10.3390/microorganisms8010127.
  2. Lee SY, Wong WF, Dong J, Cheng KK. (2020) Momordica charantia Suppresses Inflammation and Glycolysis in Lipopolysaccharide-Activated RAW264.7 Macrophages. Molecules. 2020 Aug 20;25(17):3783. doi: 10.3390/molecules25173783.
  3. Simulation of Deep Eutectic Solvents' Interaction with Membranes of Cancer Cells Using COSMO-RS. Mbous YP, Hayyan M, Wong WF, Hayyan A, Looi CY, Hashim MA. (2020) Simulation of Deep Eutectic Solvents' Interaction with Membranes of Cancer Cells Using COSMO-RS. J Phys Chem B. 2020 Oct 15;124(41):9086-9094. doi: 10.1021/acs.jpcb.0c04801.
  4. Cheong HC, Lee CYQ, Cheok YY, Shankar EM, Sabet NS, Tan GMY, Movahed E, Yeow TC, Sulaiman S, Wong WF, Looi CY, Gupta R, Hassan J, Arulanandam B, AbuBakar S. (2019) CPAF, HSP60 and MOMP antigens elicit pro-inflammatory cytokines production in the peripheral blood mononuclear cells from genital Chlamydia trachomatis-infected patients. Immunobiology. 1:34-41
  5. Cheong HC, Yap PSX, Chong CW, Cheok YY, Lee CYQ, Tan GMY, Sulaiman S, Hassan J, Sabet NS, Looi CY, Gupta R, Arulanandam B, AbuBakar S, Teh CSJ, Chang LY, Wong WF. (2019). Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia. PLoS One, 14(11): e0224658
  6. Chlamydia and Its Many Ways of Escaping the Host Immune System. Wong WF, Chambers JP, Gupta R, Arulanandam BP. J Pathog. 2019 Aug 6;2019:8604958. doi: 10.1155/2019/8604958. eCollection 2019. Review.
  7. Chlamydiaceae: Diseases in Primary Hosts and Zoonosis. Cheong HC, Lee CYQ, Cheok YY, Tan GMY, Looi CY, Wong WF. Microorganisms. 2019 May 24;7(5). pii: E146. doi: 10.3390/microorganisms7050146. Review.
  8. Emerging frontiers of deep eutectic solvents in drug discovery and drug delivery systems. Zainal-Abidin MH, Hayyan M, Ngoh GC, Wong WF, Looi CY. J Control Release. 2019 Dec 28;316:168-195. doi: 10.1016/j.jconrel.2019.09.019. Epub 2019 Oct 24. Review.
  9. Metabolomics and 16S rRNA sequencing of human colorectal cancers and adjacent mucosa. Loke MF, Chua EG, Gan HM, Thulasi K, Wanyiri JW, Thevambiga I, Goh KL, Wong WF, Vadivelu J. PLoS One. 2018 Dec 21;13(12):e0208584. doi: 10.1371/journal.pone.0208584. eCollection 2018.
  10. Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication. Loh CY, Arya A, Naema AF, Wong WF, Sethi G, Looi CY. Front Oncol. 2019 Feb 21;9:48. doi: 10.3389/fonc.2019.00048. eCollection 2019. Review.
  11. The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges. Loh CY, Chai JY, Tang TF, Wong WF, Sethi G, Shanmugam MK, Chong PP, Looi CY. Cells. 2019 Sep 20;8(10). pii: E1118. doi: 10.3390/cells8101118. Review.
  12. The Microbiome and Irritable Bowel Syndrome - A Review on the Pathophysiology, Current Research and Future Therapy. Chong PP, Chin VK, Looi CY, Wong WF, Madhavan P, Yong VC. Front Microbiol. 2019 Jun 10;10:1136. doi: 10.3389/fmicb.2019.01136. eCollection 2019.
  13. Chong PP, Chin VK, Wong WF, Madhavan P, Yong VC, Looi CY. Transcriptomic and Genomic Approaches for Unravelling Candida albicans Biofilm Formation and Drug Resistance-An Update. Genes (Basel). 2018; 9(11). pii: E540.
  14. Hematpoor A, Paydar M, Liew SY, Sivasothy Y, Mohebali N, Looi CY, Wong WF, Azirun MS, Awang K. (2018). Phenylpropanoids isolated from Piper sarmentosum Roxb. induce apoptosis in breast cancer cells through reactive oxygen species and mitochondrial-dependent pathways. Chemico-Biological Interactions, 279, 210-218.
  15. Movahed E, Cheok YY, Tan GMY, Lee CYQ, Cheong HC, Velayuthan RD, Tay ST, Chong PP, Wong WF, Looi CY. Lung-infiltrating T helper 17 cells as the major source of interleukin-17A production during pulmonary Cryptococcus neoformans infection. BMC Immunol. 2018 Nov 8;19(1):32.
  16. SR Md Zin, Z Mohamed, MA Alshawsh, WF Wong, NM Kassim. Mutagenicity evaluation of Anastatica hierochuntica L. aqueous extract in vitro and in vivo. Experimental Biology and Medicine 243 (4), 375-385
  17. Saeidi A, Zandi K, Cheok YY, Saeidi H, Wong WF, Lee CYQ, Cheong HC, Yong YK, Larsson M, Shankar EM. T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses. Front Immunol. 2018 Nov 9;9:2569. doi: 10.3389/fimmu.2018.02569. eCollection 2018. Review.
  18. Siriviriyanun, A., Tsai, Y.J., Voon, S.H., Kiew, S.F., Imae, T., Kiew, L.V., Looi, C.Y., Wong, W.F., Lee, H.B., Chung. L.Y. (2018). Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents. Materials Science & Engineering C, 89, 307-315. DOI: https://doi.org/10.1016/j.msec.2018.04.020 (IF 4.164, Tier 2)
  19. Tiong V, Shu MH, Wong WF, AbuBakar S, Chang LY (2018). Nipah virus infection of immature dendritic cells increases its transendothelial migration across human brain microvascular endothelial cells. Frontiers in Microbiology, 9:2747.
  20. Zain MA, Pandy V, Majeed ABA, Wong WF, Mohamed Z. Chronic restraint stress impairs sociability but not social recognition and spatial memory in C57BL/6J mice. Exp Anim. 2018 Nov 5. doi: 10.1538/expanim.18-0078.
  21. Zain MA, Rouhollahi E, Pandy V*, Mani V, Majeed ABA, Wong WF, Mohamed Z (2018). Phencyclidine dose optimisation for induction of spatial learning and memory deficits related to schizophrenia in C57BL/6 mice. Exp. Anim. 67(4), 421 429.
  22. Zin, Siti Rosmani Md; Mohamed, Zahurin; Alshawsh, Mohammed ; Wong, Won; Kassim, Normadiah. Mutagenicity evaluation of Anastatica hierochuntica L. aqueous extract in vitro and in vivo. Experimental Biology and Medicine Volume: 243 Issue: 4 Pages: 375-385 Published: FEB 2018. DOI: 10.1177/1535370217748574
  23. Jee PF, Chen FS, Shu MH, Wong WF, Abdul Rahim R, AbuBakar S, Chang LY. Insertion of single-chain variable fragment (scFv) peptide linker improves surface display of influenza hemagglutinin (HA1) on non-recombinant Lactococcus lactis. Biotechnol Prog. 2017 Jan;33(1):154-162.
  24. Oral immunization of a non-recombinant Lactococcus lactis surface displaying influenza hemagglutinin 1 (HA1) induces mucosal immunity in mice. Jee PF, Tiong V, Shu MH, Khoo JJ, Wong WF, Abdul Rahim R, AbuBakar S, Chang LY. PLoS One. 2017 Nov 6;12(11):e0187718.
  25. S. Abdullah,1 W. F. Wong,2 and C. T. Tan1, 2017. The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis. Multiple Sclerosis International Volume 2017, Article ID 1359761, 6 pages
  26. Wu, YS, Chung I, Wong WF, Masamune A, Sim MS, and Looi CY (2016). Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells. Biochimica et Biophysica Act, 1861, 296-306. (Impact factor: 4.702)
  27. Y.P. Mbous, M. Hayyan, A. Hayyan, W.F. Wong, M.A. Hashim, C.Y. Looi. Applications of Deep Eutectic Solvents in Biotechnology and Bioengineering--Promises and Challenges, Biotechnology Advances, 35, 105-134, 2017.
  28. Y.P. Mbous, M. Hayyan, W.F. Wong, C.Y. Looi, M.A. Hashim. Unraveling the cytotoxicity and metabolic pathways of binary natural deep eutectic solvent systems, Scientific Reports, 7, 41257; doi: 10.1038/srep41257, 2017.
  29. Aydin Tekdas, D., Viswanathan, G., Zehra Topal, S., Looi, C. Y., Wong, W. F., Min Yi Tan, G., . . . Dumoulin, F. (2016). Antimicrobial activity of a quaternized BODIPY against Staphylococcus strains. Org Biomol Chem, 14(9), 2665-2670. doi: 10.1039/c5ob02477c
  30. Hasanpourghadi, M., Karthikeyan, C., Pandurangan, A. K., Looi, C. Y., Trivedi, P., Kobayashi, K., . . . Mustafa, M. R. (2016). Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell. J Exp Clin Cancer Res, 35, 58. doi: 10.1186/s13046-016-0332-0
  31. Hasanpourghadi, M., Looi, C. Y., Pandurangan, A. K., Sethi, G., Wong, W. F., & Mustafa, M. R. (2016). Phytometabolites Targeting Warburg Effect in Cancer Cells: A Mechanistic Review. Curr Drug Targets.
  32. Jee, P. F., Chen, F. S., Shu, M. H., Wong, W. F., Abdul Rahim, R., AbuBakar, S., & Chang, L. Y. (2016). Insertion of single-chain variable fragment (scFv) peptide linker improves surface display of influenza hemagglutinin (HA1) on non-recombinant Lactococcus lactis. Biotechnol Prog. doi: 10.1002/btpr.2400
  33. M. Hayyan, Y. P. Mbous, C. Y. Looi, W. F. Wong, A. Hayyan, Z. Salleh, O. Mohd Ali. (2016). Natural deep eutectic solvents: cytotoxic profile. Springerplus, 5(1), 913. doi: 10.1186/s40064-016-2575-9
  34. Movahed, E., Tan, G. M., Munusamy, K., Yeow, T. C., Tay, S. T., Wong, W. F., & Looi, C. Y. (2016). Triclosan Demonstrates Synergic Effect with Amphotericin B and Fluconazole and Induces Apoptosis-Like Cell Death in Cryptococcus neoformans. Front Microbiol, 7, 360. doi: 10.3389/fmicb.2016.00360
  35. Tan, G. M., Lim, H. J., Yeow, T. C., Movahed, E., Looi, C. Y., Gupta, R., . . . Wong, W. F. (2016). Temporal proteomic profiling of Chlamydia trachomatis-infected HeLa-229 human cervical epithelial cells. Proteomics, 16(9), 1347-1360. doi: 10.1002/pmic.201500219
  36. Wu, Y. S., Chung, I., Wong, W. F., Masamune, A., Sim, M. S., & Looi, C. Y. (2016). Paracrine IL-6 signaling mediates the effects of pancreatic stellate cells on epithelial-mesenchymal transition via Stat3/Nrf2 pathway in pancreatic cancer cells. Biochim Biophys Acta. doi: 10.1016/j.bbagen.2016.10.006
  37. Yeow, T. C., Wong, W. F., Sabet, N. S., Sulaiman, S., Shahhosseini, F., Tan, G. M., . . . Abu Bakar, S. (2016a). Erratum: prevalence of plasmid-bearing and plasmid-free chlamydia trachomatis infection among women who visited obstetrics and gynecology clinics in Malaysia. BMC Microbiol, 16, 95. doi: 10.1186/s12866-016-0701-z
  38. Abdullah S, Lim KS, Tan HJ, Wong WF, and Tan CT. EEG is Sensitive in Early Diagnosis of Anti NMDAR Encephalitis and Useful in Monitoring Disease Progress. Neurology Asia 2015; 20(2):167-75
  39. Jamali H, Paydar M, Ismail S, Looi CY, Wong WF, Radmehr B, Abedini A. Prevalence, antimicrobial susceptibility and virulotyping of Listeria species and Listeria monocytogenes isolated from open-air fish markets. BMC Microbiology. 2015; 15:144.
  40. Movahed E, Munusamy K, Tan GM, Looi CY, Tay ST, Wong WF*. Genome-wide transcriptional study of Cryptococcus neoformans H99 clinical strain versus environmental strains. PLOS ONE. 2015; 10(9):e0137457
  41. Siriviriyanun A, Popova M, Imae T, Kiew LV, Looi CY, Wong WF, Lee HB, Chung LY. Preparation of graphene oxide/dendrimer hybrid carriers for delivery of doxorubicin. Chemical Engineering Journal. 2015; 281:771 81
  42. Tan GM, Looi CY, Fernandez KC, Vadivelu J, Loke MF, Wong WF*. Suppression of cell division-associated genes by Helicobacter pylori attenuates proliferation of RAW264.7 monocytic macrophage cells. Scientific Reports. 2015; 5:11046
  43. Wong WF*, Kohu K, Nagashima T, Funayama R, Matsumoto M, Movahed E, Tan GM, Yeow TC, Looi CY, et al. The artificial loss of Runx1 reduces the expression of quiescence-associated transcription factors in CD4+ T lymphocytes. Molecular Immunology. 2015; 68(2 Pt A):223-33
  44. Liew SY, Looi CY, Paydar M, Cheah FK, Leong KH, Wong WF, Mustafa MR, Litaudon M, Awang K. Subditine, a new monoterpenoid indole alkaloid from bark of Nauclea subdita (Korth.) Steud. induces apoptosis in human prostate cancer cells. PLoS One. 2014 Feb 14;9(2):e87286. doi: 10.1371/journal.pone.0087286. eCollection 2014.
  45. Looi CY, Sasahara Y, Watanabe Y, Satoh M, Hakozaki I, Uchiyama M, Wong WF, Du W, Uchiyama T, Kumaki S, Tsuchiya S, Kure S. The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells. International Immunology. 2014 Jun;26(6):341-52. doi: 10.1093/intimm/dxt072. Epub 2014 Jan 8.
  46. Narrima P, Paydar M, Looi CY, Wong YL, Taha H, Wong WF, Ali Mohd M, Hadi AH. Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via G0/G1 Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation. Evid Based Complement Alternat Med. 2014;2014:248103. doi: 10.1155/2014/248103. Epub 2014 Apr 7.
  47. Shawish HB, Wong WY, Wong YL, Loh SW, Looi CY, Hassandarvish P, Phan AY, Wong WF, Wang H, Paterson IC, Ea CK, Mustafa MR, Maah MJ. Nickel(II) complex of polyhydroxybenzaldehyde N4-thiosemicarbazone exhibits anti-inflammatory activity by inhibiting NF-κB transactivation. PLoS One. 2014 Jun 30;9(6):e100933. doi: 10.1371/journal.pone.0100933. eCollection 2014.
  48. Syam S, Bustamam A, Abdullah R, Sukari MA, Hashim NM, Mohan S, Looi CY, Wong WF, Yahayu MA, Abdelwahab SI. β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo. J Ethnopharmacol. 2014 Apr 28;153(2):435-45. doi: 10.1016/j.jep.2014.02.051. Epub 2014 Mar 6.
  49. Wong WF*, Looi CY, Kon S, Mohaved E, Funaki T, Chang LY, Satake M, Kohu K. T-cell receptor signaling induces proximal Runx1 transactivation via a calcineurin-NFAT pathway. Eur J Immunol. 2013. 44(3):894-904.
  50. Chung Yeng Looi, Bushra Moharram, Mohammadjavad Paydar, Yi Li Wong, Kok Hoong Leong, Khalit Mohamad, Aditya Arya, Won Fen Wong and Mohd Rais Mustafa. Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways. BMC Complementary and Alternative Medicine 2013, 13:166. doi:10.1186/1472- 6882-13-166
  51. Funaki T, Kon S, Tanabe K, Natsume W, Sato S, Shimizu T, Yoshida N, Wong WF, Ogura A, Ogawa T, Inoue K, Ogonuki N, Miki H, Mochida K, Endoh K, Yomogida K, Fukumoto M, Horai R, Iwakura Y, Ito C, Toshimori K, Watanabe T, Satake M. The Arf GAP SMAP2 is necessary for organized vesicle budding from the trans-Golgi network and subsequent acrosome formation in spermiogenesis. Mol Biol Cell. 2013 Sep;24(17):2633- 2644. Epub 2013 Jul 17.
  52. Kon S, Minegishi N, Tanabe K, Watanabe T, Funaki T, Wong WF, Sakamoto D, Higuchi Y, Kiyonari H, Asano K, Iwakura Y, Fukumoto M, Osato M, Sanada M, Ogawa S, Nakamura T, Satake M. Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia. J Clin Invest. 2013 Mar 1;123(3):1123- 37. doi: 10.1172/JCI63711. (Impact factor: 13.069)
  53. Looi CY, Arya A, Cheah FK, Muharram B, Leong KH, Mohamad K, Wong WF, Rai N, Mustafa MR. Induction of Apoptosis in Human Breast Cancer Cells via Caspase Pathway by Vernodalin Isolated from Centratherum anthelminticum (L.) Seeds. PLoS One. 2013;8(2):e56643. doi: 10.1371/journal.pone.0056643. (Impact factor: 4.092)
  54. Ismail Adam Arbab, Chung Yeng Looi, Ahmad Bustamam Abdul, Foo Kit Cheah, Won Fen Wong, Mohd Aspollah Sukari, Rasedee Abdullah, Syam Mohan, Suvitha Syam, Aditya Arya, Manal Mohamed Elhassan Taha, Bushra Muharram, Mohd Rais Mustafa and Siddig Ibrahim Abdelwahab. 2012. Dentatin induces apoptosis in prostate cancer cells via Bcl-2, Bcl-xL, Survivin downregulation, caspase-9, -3/7 activation and NF-kB inhibition. Evidence-Based Complementary and Alternative Medicine. 2012:1-15. (Impact factor 4.77).
  55. Wong WF, Kohu K, Nakamura A, Ebina M, Kikuchi T, Tazawa R, Tanaka K, Kon S, Funaki T, Sugahara-Tobinai A, Looi CY, Endo S, Funayama R, Kurokawa M, Habu S, Ishii N, Fukumoto M, Nakata K, Takai T, Satake M. 2012. Runx1-deficiency causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells. The Journal of Immunology;188:5408-5420. (Impact factor:5.79).
  56. Wong WF, Kohu K, Chiba T, Sato T, Satake M. 2011. Interplay of transcription factors in T-cell differentiation and function: the role of Runx. Immunology; 130(2):157-164. Impact factor: 3.32
  57. Wong WF, Kurokawa M, Satake M, Kohu K. 2011. Down-regulation of Runx1 expression by TCR signal involves an auto-regulatory mechanism and contributes to IL-2 production. The Journal of Biological Chemistry; 286(13):11110-11118. (Impact factor: 4.77)
  58. Wong WF, Nakazato M, Watanabe T, Kohu K, Ogata T, Yoshida N, Sotomaru Y, Ito M, Araki K, Telfer J, Fukumoto M, Suzuki D, Sato T, Hozumi K, Habu S, Satake M. (2010) Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages. Immunology; 130(2):243-253. (Impact factor 3.32)
  59. Kohu K, Ohmori H, Wong WF, Onda D, Wakoh T, Kon S, Yamashita M, Nakayama T, Kubo M, Satake M. 2009. The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. The Journal of Immunology; 183(12):7817-7824.
  60. Lim CS, Wong WF, Rosli R, Ng KP, Seow HF, Chong PP. 2009. 2-dodecanol (decyl methyl carbinol) inhibits hyphal formation and SIR2 expression in C. albicans. Journal of Basic Microbiology; 49(6):579-583. (Impact factor: 1.27)
Chapter in Books
  1. Neama, A.F., Looi, C.Y., & Wong, W.F. (2017). Multiple Players in the Mechanical Control of T Cell Quiescence. Lymphocyte Updates - Cancer, Autoimmunity and Infection. (pg 97-110). In Tech. http://dx.doi.org/10.5772/intechopen.68869
Article in Proceeding
  1. Suhailah Abdullah, Lim Kheng Seang, Tan Hui Jan, Wong Won Fen, Tan Chong Tin. EEG is Sensitive in Early Diagnosis of Anti NMDAR Encephalitis and Useful in Monitoring Disease Progress.Lancet Neuroimmunology Conference, 2015.

PAPER PRESENTED

INVITED SPEAKER
  1. 3D culture in Tumor Immunology, 3D Cell Culture Seminar, IBS, UPM (National) (21 Nov 2016 - 21 Nov 2016)
  2. Aquaporin4 (AQ4) Antibodies In Neuromyelitis Optica, Immune System and Nerves: An Introductory Lecture Series, Malaysian Society of Neurosciences (National) (28 Jul 2016 - 28 Jul 2016)
ORAL PRESENTER
  1. Runx1 deficiency in CD4+ T cells causes loss of cell quiescence, Immunology Symposium, University Putra Malaysia (National) (16 Oct 2014 - 17 Oct 2014)
POSTER PRESENTER
  1. Runx1 transcription factor maintains T cell quiescence, 7th Annual Vaccine Development Center of San Antonio Conference : Infection, Immunity and Vaccines, vaccine Development Center San Antonio (International) (16 Nov 2018 - 17 Nov 2018)
  2. Runx1 transcription factor and T cell quiescence, 3rd Abbas Advanced Course in Basic and Clinical Immunology, Mahidol University (International) (08 Feb 2018 - 09 Feb 2018)
  3. Chlamydia trachomatis infection restrains translational initiation machinery in the host epithelial cells , ASMEIT (Annual Scientific Meeting on Emerging Infectious Threat) 2017, MSIDC (Malaysia Society of Infectious Diseases and Chemotherapy (National) (19 May 2017 - 20 May 2017)
  4. Suppression of cell division-associated genes by Helicobacter pylori attenuates proliferation of RAW264.7 monocytic macrophage cells., International Congress of Malaysian Society for Microbiology 2015 (ICMSM 2015), Malaysian Society of Microbiology (International) (07 Dec 2015 - 09 Dec 2015)
  5. Genome-wide transcription study of Cryptococcus neoforman H99 clinical strain versus environmental strains, International Congress of Malaysian Society for Microbiology (ICMSM2015), Malaysian Society for Microbiology (International) (07 Dec 2015 - 09 Dec 2015)
  6. Runx1 deficiency in CD4+T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells, 15th International Congress of Immunology, iuis (International) (22 Aug 2013 - 27 Jan 2014)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2022) Panel Reviewer for Dom-Rsf Cycle 3, 2022, University, (Reviewer)
  2. (2022) Md-D-21-04283r1, International, (Reviewer)
  3. (2019) FRONTIERS IN IMMUNOLOGY, (REVIEW EDITOR)
  4. (2019) FRONTIERS IN MICROBIOLOGY, (REVIEW EDITOR)
  5. (2018) FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, (REVIEW EDITOR)
  6. (2017) Asia Pacific Journal of Public Health APJPH 17 Apr 235 , (Reviewer)
  7. (2017) Microbiology MIC D 17 00040 , (Reviewer)
  8. (2017) Journal of Transdisciplinary Biomedicine , (Reviewer)
  9. (2017) JSM Bone Marrow Research , (Reviewer)
  10. (2017) Medicine D D 17 01831 , (Reviewer)
  11. (2017) Taylor's University , (Reviewer)
  12. (2017) Biomedicine & Pharmacotherapy BIOPHA_2017_1217 , (Reviewer)
  13. (2017) LDDD Ms for Review 1814 , (Reviewer)
  14. (2017) BMC Infectious Diseases INFD D 17 00319 , (Reviewer)
  15. (2017) Molecular Immunology MIMM D 17 00220 , (Reviewer)
  16. (2017) Sultan Qaboos University Medical Journal , (Reviewer)
  17. (2017) MSc- Tan Ming Cheang (SGR130049) Biological Screening for Anti-Influenza A Virus Agents, (Internal Examiner)
  18. (2016) PhD - YONG YEAN KONG (MHA090003) - THE ROLE OF CD14 AND TLR4 SINGLE NUCLEOTIDE POLYMORPHISMS IN CD4+ T-CELL RECOVERY AND CARDIOVASCULAR DISEASE IN HIV-INFECTED PATIENTS FOLLOWING cART, (Internal Examiner)
  19. (2016) Reproductive Health (REPH-D-16-00173), (Reviewer)
  20. (2016) Taylor's University Conference paper, (Reviewer)
  21. (2016) Scientific Reports (SREP-16-06030A), (Reviewer)
  22. (2016) MSc - AW YONG KAM LENG (MGN120036) - CHARACTERIZATION OF THE ADAPTIVE IMMUNE RESPONSES IN ENTEROVIRUS 71 INFECTION, (Internal Examiner)
  23. (2016) J Ethno pharmacology (JEP-D-16-01293), (Reviewer)
  24. (2016) PLOS ONE (PONE-D-16-09154), (Reviewer)
  25. (2016) PhD - KANG WEN TYNG (MHA120070) - FUNCTIONAL CHARACTERISATION OF TYPE III SECRETION SYSTEM EFFECTOR PROTEIN, BIPC, IN BURKHOLDERIA PSEUDOMALLEI PATHOGENESIS, (Internal Examiner)
  26. (2016) Journal of Cytology & Tissue Biology (HCTB-16-005), (Reviewer)
  27. (2016) MSc - SEE JIA XIANG (MGN140045) - Mechanism Of T-Cell Exhaustion Associated With Experimental Persistent Burkholderia Pesudomallei Infection In Balb/C Mice, (Internal Examiner)
  28. (2016) Scientific Reports (SREP- 16- 26647), (Reviewer)
  29. (2016) PLOS ONE (PONE-D-16-08265), (Reviewer)
  30. (2016) PLOS ONE (PONE-D-16-05430), (Reviewer)
  31. (2016) Medicine (MDD-16-00770), (Reviewer)
  32. (2016) Medicine (MD D -16- 00300), (Reviewer)
  33. (2015) MSc - Choh Leang Chung - Role of BapA Type III Effector in the Intracellular Lifecycle of Burkholderia pseudomallei , (Internal Examiner)
  34. (2015) MBEB 4180 - Vicky Lau - Investigations on biosignatures of immuneinhibition on mucosaassociated invariant T (MAIT) cells in HIV1/Tuberculosis coinfection, (Internal Examiner)
  35. (2015) MBEB 4180 - Faizah Yahaya - Prevalence of Blastocystis, Dientoamoeba Fragilis and other intestinal parasites in orang asli , (Internal Examiner)
  36. (2014) MSc - Adeline Yeo Syin Lian - A Comparative Study on prM Antibodies, E antibodies and immune response genes between dengue patients and their asymptomatic counterparts , (Internal Examiner)
  37. (2014) MBEB 4180 - Chong Yee Kien - Comparative investigation on immunosenescence in HIV/tuberculosis coinfection, (Internal Examiner)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2023) Investigating the Functions of Helper T and Circulating Helper-like Innate Lymphoid Cells in Mediating the Disease Onset and Relapses of Autoimmune Demyelinating Disease of the Central Nervous System, LOH KAR MIN
  2. (2023) Role of RUNX1 in plasma cell differentiation in Multiple myeloma patients, TANG TING FANG
  3. (2023) Metabolic Dysfunction of the Exhausted T Cell in Chronic Human Immunodeficiency Virus Infection, CHAN YEE TENG
  4. (2023) UNDERSTANDING THE IMMUNOLOGICAL MEMORY FOR IMMUNE PROTECTION IN CONVALESCENT NIPAH PATIENTS VIA EX VIVO ANTIGENIC RESTIMULATION, PUTERI AINAA SYAHIRAH BINTI IBRAHIM
  5. (2022) Decrypting the Intricate Interplay between Chlamydia Trachomatis and Host Cell Mitochondria, CHEONG HENG CHOON
  6. (2021) THE EXPRESSION AND FUNCTION OF PODOPLANIN IN HELICOBACTER PYLORI-INFECTED MACROPHAGES, CHEOK YI YING
  7. (2019) ENHANCEMENT OF GRAPHENE BIOCOMPATIBILITY AS A POTENTIAL NANO-CARRIER FOR DRUG DELIVERY APPLICATIONS USING NATURAL DEEP EUTECTIC SOLVENTS, MOHAMAD HAMDI BIN ZAINAL ABIDIN
  8. (2017) THE ROLE OF MONOCYTES AND DENDRITIC CELLS IN THE MIGRATION OF NIPAH VIRUS ACROSS THE BLOOD-BRAIN BARRIER, TIONG VUNJIA
  9. (2017) Investigation on the role of PDLIM5 gene in Cognitive Function using Mouse Models, MOHD AIZAT BIN MOHD ZAIN
  10. (2016) Influenza hemagglutinin 1 (HA1) surface-displayed on Lactococcus lactis in the induction of protective mucosal immunity against influenza virus, JEE PUI FONG
  11. (2016) Comparative transcriptome analysis of clinical and environmental strains of Cryptococcus neoformans and an investigation on anti-Cryptococcus activity of triclosan, ELAHEH MOVAHED
Master
  1. (2023) DC+CIK Combined Immunotherapy Enhances Efficacy Of Chemotherapy Regime For Pancreatic Cancer, THIAN QIN ZHANG
  2. (2018) ASSOCIATION BETWEEN GENITAL MICROBIOME AND PLASMID-ENCODED PGP3 PROTEIN WITH GENITAL CHLAMYDIA TRACHOMATIS INFECTION, CHEONG HENG CHOON
  3. (2016) PROFILING THE CYTOTOXICITY OF DEEP EUTECTIC SOLVENT SYSTEMS AND THEIR POTENTIAL APPLICATIONS AS ANTICANCER AGENTS, YVES PAUL VINCENT MBOUS
  4. (2015) HELICOBACTER PYLORI ATTENUATES PROLIFERATION OF RAW 264.7 MONOCYTIC MACROPHAGE CELLS BY DOWNREGULATING CELL CYCLE GENES, GRACE TAN MIN YI
  5. (2013) A Comparative Study Of Plasmid-Bearing And Plasmid-Deficient Chlamydia Trachomatis Infection In Women With Fertility Disorders., Yeow Tee Cian
Under Graduate Students
  1. (2022) Mitochondrial Dynamics in Chlamydia trachomatis-InfectedCervical Epithelial Cells

TEACHING

Master
  1. (2022) MPATH - Master of Pathology
  2. (2019) MPATH - Basic and Advanced Immunology
  3. (2014) Master of Medical Science in Clinical Pathology
  4. (2014) Master of Pathology
  5. (2014) Postgraduate Basic/Clinical Science Teaching Program
  6. (2012) Master of Pathology Year 1
Bachelor
  1. (2022) UMMP - Ummp Block 5: Ige Mediated Responses
  2. (2022) UMMP - Ummp Block 6: Immunodeficiency and Common Opportunistic Infections
  3. (2022) MIC3005 - Advanced Medical Bacteriology and Mycology
  4. (2022) MIC3011 - Advances in Medical Virology
  5. (2022) MIC4004 - Diagnostic Bacteriology and Mycology
  6. (2022) DIA2005 - Medical Microbiology
  7. (2022) MID1010 - Microbiology and Parasitology
  8. (2019) MEDIC -
  9. (2019) MIC2007 - Microbial Infections
  10. (2016) DIA2005 - Medical Microbiology
  11. (2016) MIA1001 - Medical Sciences 1 (Ummp)
  12. (2015) UMMP - Immunology
  13. (2014) DJED2101 - Medical Microbiology
  14. (2014) MBBS - Medical Microbiology
  15. (2014) MFEB2404 - Introductory Diagnostic Virology
  16. (2014) MFEB3401 - Advanced Medical Virology
  17. (2014) MFEB3403 - Advanced Diagnostic Virology
  18. (2014) UMMP - Immunology
  19. (2013) DJED2101 - Medical Microbiology
  20. (2013) MBBS - Medical Microbiology
  21. (2013) MFEB2403 - Introductory Diagnostic Microbiology
  22. (2013) MTEJ1120 - Parasitology and Microbiology
  23. (2013) UMMP - Immunology
  24. (2012) DJED2101 - Medical Microbiology
  25. (2012) MBBS II - Medical Microbiology
Others
  1. (2013) Dmtl2622