Curriculum Vitae

PROF. DR. KAM TOH SEOK

Honorary Professor
  • Department of Chemistry
    Faculty of Science
  • tskam
  • 79674266

AREAS OF EXPERTISE

  • ORGANIC CHEMICAL SYNTHESIS
    Biomimetic Partial Synthesis; Electroorganic synthesis; Indole derivatives; Oligostilbenoids
  • NATURAL PRODUCTS CHEMISTRY
    Natural Products; Alkaloids; Structure; Reactivity; Bioactivity

ACADEMIC QUALIFICATION

  • PhD (UM)(1979), (Lain-Lain)
    Universiti Malaya (UM)
  • BSc (Hons)(Chemistry)(UM)(1974), (KIMIA)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • Head of Organic/Organometallic Research Group under Frontier Science (AFR) Cluster
    01 Jan 2013 - 31 Dec 2014 (University Malaya)

AWARD AND STEWARDSHIP

  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 1995 (University)

PUBLICATIONS

Article in Journal
  1. M. E. Qazzaz, V. J. Raja, K. H. Lim, T. S. Kam, J. B. Lee, P. V. Gershkovich, T. D. Bradshaw. In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B. Cancer Letters, accepted 9 Oct 2015
  2. F. J. Hong, K. W. Chong, Y. Y. Low, N. F. Thomas, T. S. Kam. Transformations of Ferric Chloride Generated Stilbene Cation Radicals. The Effect of Aromatic Substitution and a Comparison with Anodic Oxidation. Chemistry An Asian Journal (invited submission for Special Board Members Issue), 2015, 10, 2207-2220.
  3. J. L. Lim, K. S. Sim, K. T. Yong, B. J. Loong, K. N. Ting, S. H. Lim, Y. Y. Low, T. S. Kam. Biologically active vallesamine, strychnan, and rhazinilam alkaloids from Alstonia: Pneumatophorine, a nor-secovallesamine with unusual incorporation of a 3-ethylpyridine moiety. Phytochemistry 2015, 117, 317-324
  4. K. H. Lim, V. J. Raja, T. D. Bradshaw, S. H. Lim, Y. Y. Low, T. S. Kam. Ibogan, Tacaman, and Cytotoxic Bisindole Alkaloids from Tabernaemontana. Cononusine, an Iboga Alkaloid with Unusual Incorporation of a Pyrrolidone Moiety. J. Nat. Prod. 2015, 78, 1129-1138.
  5. S. P. Wong, C. Y. Gan, K. H. Lim, K. N. Ting, Y. Y. Low, T. S. Kam. Arboridinine, a pentacyclic indole alkaloid with a new cage carbon- nitrogen skeleton derived from a pericine precursor. Org. Lett. 2015, 17, 3628-3631.
  6. Veronica Alicia Yap; Bi-Juin Long; Kang-Nee Ting; Hwei-San Loh; Kien- Thai Yong; Yun-Yee Low; Toh-Seok Kam; Kuan-Hon Lim. Hispidacine, an unusual 8,4'- oxyneolignan-alkaloid with vasorelaxant activity, and hispiloscine, an antiproliferative phenanthroindolizidine alkaloid, from Ficus hispida Linn. Phytochemistry, 2015, 109, 96 102.
  7. Gan, C. Y.; Yoganathan, K.; Sim, K. S.; Low, Y. Y.; Lim, S. H.; Lim, S. H.; Kam, T. S., Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora, Phytochemistry, 2014, 109, 234-242.
  8. Hong, F. J.; Low, Y. Y.; Chong, K. W.; Thomas, N. F.; Kam, T. S. Biomimetic Oxidative Dimerization of Anodically Generated Stilbene Radical Cations: Effect of Aromatic Substitution on Product Distribution and Reaction Pathways, J. Org. Chem. 2014, 79, 4528-4543
  9. Lim, S. H.; Low, Y. Y.; Sinniah, S. K.; Yong, K. T.; Sim, K. S.; Kam, T. S. Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia Macrophylla, Phytochemistry, 2014, 98, 204-215.
  10. Low, Y. Y.; Gan, C. Y.; Kam, T. S. Andransinine: An Unusual Case of Spontaneous Resolution in an Indole Alkaloid Derivative, J. Nat. Prod., 2014, 77, 1532-1535.
  11. Low, Y. Y.; Hong, F. J.; Lim, K. H.; Thomas, N. F.; Kam, T. S. Transformations of the 2,7-Seco Aspidosperma Alkaloid Leuconolam,Structure Revision of epi- Leuconolam, and Partial Syntheses of Leuconoxine and Leuconodines A and F., J. Nat. Prod., 2014, 77, 327-338.
  12. Nge, C. Y.; Gan, C. Y.; Lim, K. H.; Ting, K. N.; Low, Y. Y.; Kam, T. S. Criofolinine and Vernavosine, New Pentacyclic Indole Alkaloids Incorporating Pyrroloazepine and Pyridopyrimidine Moieties Derived From a Common Yohimbine Precursor. Org. Lett. 2014, 16, 6330−6333.
  13. Raja, V. J.; Lim, K. H.; Leong, C. O.; Kam, T. S.; Bradshaw, T. D., Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2​/M cell cycle arrest targeting microtubules, Invest. New Drugs., 2014, 32, 838 850.
  14. Sim, Dawn Su-Yin; Chong, Kam-Weng; Nge, Choy-Eng; Low, Yun-Yee; Sim, Kae-Shin; Kam, Toh-Seok, Cytotoxic Vobasine, Tacaman, and Corynanthe-Tryptamine Bisindole Alkaloids from Tabernaemontana and Structure Revision of Tronoharine, J. Nat. Prod. 2014, 77, 2504−2512.
  15. Tan, S. J.; Lim, J. L.; Low, Y. Y.; Sim, K. S.; Lim, S. H.; Kam, T. S., Oxidized Derivatives of Macroline, Sarpagine, and Pleiocarpamine Alkaloids from Alstonia angustifolia, J. Nat. Prod., 2014, J. Nat. Prod., 2014, 77, 2068 2080
  16. Chew-Yan Gan , Yun-Yee Low , Noel F. Thomas , and Toh- Seok Kam. Voatinggine and Tabertinggine, Pentacyclic Indole Alkaloids Derived from an Iboga Precursor via a Common Cleavamine-Type Intermediate, Org. Lett.,2013, 15, 4774-4777.
  17. Chew-Yan Gan, Yun-Yee Low, Noel F. Thomas, and Toh-Seok Kam. Rhazinilam−Leuconolam−Leuconoxine Alkaloids from Leuconotis griffithii, J. Nat. Prod. 2013, 76, 957−964.
  18. Siew-Huah Lim, Yun-Yee Low, G. Subramaniam, Zanariah Abdullah, Noel F. Thomas, Toh-Seok Kam, Lumusidines A - D and villalstonidine F, macroline macroline and macroline pleiocarpamine bisindole alkaloids from Alstonia macrophylla, Phytochemistry, 2013, 87, 148-156.
  19. Robert E. Ziegler, Shin-Jowl Tan, Toh-Seok Kam, and John A. Porco Jr. 2012. Development of an Alkaloid Pyrone Annulation: Synthesis of Pleiomaltinine. Angewandte Chemie Int. Ed., 51, 9348-9351
  20. S. H. Lim, S. J. Tan, Y. Y. Low, K. H. Lim, N. F. Thomas, T. S. Kam, Perhentidines A C: Macroline-Macroline Bisindoles from Alstonia and the Absolute Configuration of Perhentinine and Macralstonine. J. Natural Products, 2012, 75, 942-950
  21. S. J. Tan, G. Subramaniam, N. F. Thomas, T. S. Kam, Unusual Nitrogenous Derivatives from Alstonia, Natural Product Communications, 2012, 7, 739-742
  22. S. J. Tan, K. H. Lim, G. Subramaniam, Toh-Seok Kam. Macroline-sarpagine and macroline-pleiocarpamine bisindole alkaloids from Alstonia angustifolia. Phytochemistry, 2012, accepted for publication, 21 June 2012.
  23. S. H. Lim, S. J. Tan, Y. Y. Low, T. S. Kam, Lumutinines A-D, Linearly Fused Macroline-Macroline and Macroline-Sarpagine Bisindoles from Alstonia macrophylla, J. Natural Products, 2011, 74, 2556-2562.
  24. S. J. Tan, W. T. Robinson, K. Komiyama, T. S. Kam, Macrodasine A-G, macroline indole alkaloids incorporating fused spirocyclic tetrahydrofuran-tetrahydrofuran and tetrahydrofuran-tetrahydropyran rings, Tetrahedron, 2011, 67, 3830-3838.
  25. W. F. Ku, S. J. Tan, Y. Y. Low, K. Komiyama, T. S. Kam, Angustilobine and andranginine type indole alkaloids and an uleine-secovallesamine bisindole alkaloid from Alstonia angustiloba, Phytochemistry, 2011, 72, 2212-2218.
  26. W. S. Yap, C. Y. Gan, Y. Y. Low, Y. M. Choo, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Grandilodines A-C, Biologically Active Indole Alkaloids from Kopsia grandifolia, J. Natural Products, 2011, 74, 1309- 1312.
  27. C. Y. Gan, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Leucoridines A D, Cytotoxic Strychnos-Strychnos Bisindole Alkaloids from Leuconotis, J. Natural Products, 2010, 73, 1107-1111.
  28. C. Y. Gan, Y. Y. Low, W. T. Robinson, K. Komiyama, and T. S. Kam, Aspidospermatan-aspidospermatan and eburnane-sarpagine bisindole alkaloids from Leuconotis, Phytochemistry, 2010, 71, 1365-1370.
  29. S. J. Tan, Y. M. Choo, N. F. Thomas, W. T. Robinson, K. Komiyama, and T. S. Kam, Unusual indole alkaloid-pyrrole, -pyrone, and carbamic acid adducts from Alstonia angustifolia, Tetrahedron, 2010, 66, 7799- 7806.
  30. S. J. Tan, Y. Y. Low, Y. M. Choo, Z. Abdullah, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Strychnan and secoangustilobine A type alkaloids from Alstonia spatulata. Revision of the C-20 configuration of scholaricine, J. Natural Products, 2010, 73, 1891-1897.
  31. Y. Y. Low, K. H. Lim, Y. M. Choo, H. S. Pang, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Structure, biological activity and biomimetic partial synthesis of the lirofolines, novel pentacylic indole alkaloids from Tabernaemontana, Tetrahedron Letters, 2010, 51, 269-272.
  32. C. Y. Gan and T. S. Kam, Leucolusine, a tetracyclic alkaloid with a novel ring system incorporating an oxindole moiety and fused piperidine- tetrahydrofuran rings, Tetrahedron Letters, 2009, 50, 1059-1061.
  33. C. Y. Gan, W. T. Robinson, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Leucophyllidine, a cytotoxic bisindole alkaloid constituted from the union of a eburnan and a novel vinylquinoline alkaloid, Organic Letters, 2009, 11, 3962-3965.
  34. Gan, C. Y., Low, Y. Y., Etoh, T., Hayashi, M., Komiyama, K., and Kam, T. S. Leuconicines A G and (−)-Eburnamaline, Biologically active strychnan and eburnan alkaloids from Leuconotis. J. Nat. Prod., 2009, 72, 2098- 2103.
  35. K. H. Lim and T. S. Kam, Conoliferine and isoconoliferine, structurally novel alkaloid-lignan conjugates from Tabernaemontana corymbosa, Tetrahedron Letters, 2009, 50, 3756-3759
  36. K. H. Lim and T. S. Kam, Conomicidines A and B, Unusual Alkaloid- Hydroxycinnamyl Alcohol Conjugates from Tabernaemontana corymbosa, Helvetica Chimica Acta, 2009, 92, 1895-1902.
  37. K. H. Lim, K. M. Sim, and T. S. Kam, Four tetracyclic oxindole alkaloids and a taberpsychine derivative from a Malayan Tabernaemontana, Phytochemistry, 2009, 70, 1182 1186
  38. K. H. Lim, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Conolutinine, a Hexacyclic Indole Alkaloid with a Novel Ring System Incorporating a Diazaspiro center and Fused Oxadiazepine-Tetrahydrofuran Rings, Tetrahedron Letters, 2009, 50, 752-754
  39. Lim, K. H., Thomas, N. F., Abdullah, Z. and Kam, T. S. 2009. Seco- tabersonine alkaloids from Tabernaemontana corymbosa. Phytochemistry 70: 424-429.
  40. Y. Y. Low, G. Subramaniam, K. H. Lim, R. C. S. Wong, Ward T. Robinson, and T. S. Kam, Mersiphyllines A and B from Kopsia. Determination of relative configuration at a quaternary center via formation of an alkaloid- borane complex, Tetrahedron, 2009, 65, 6873-6876
  41. G. Subramaniam and T. S. Kam, New indole alkaloids from Kopsia. Alkaloid variation in K. singapurensis, Helv. Chim. Acta, 2008, 91, 930-937.
  42. G. Subramaniam, O. Hiraku, M. Hayashi, T. Koyano, K. Komiyama, and T. S. Kam, Biologically active aspidofractinine alkaloids from Kopsia singapurensis, J. Natural Products, 2008, 71, 53-57.
  43. G. Subramaniam, Y. M. Choo, O. Hiraku, K. Komiyama, and T. S. Kam, The alkaloids of the mersinine group: a new subclass of the monoterpenoid indole alkaloids from Kopsia, Tetrahedron, 2008, 64, 1397-1408.
  44. K. H. Lim and T. S. Kam, Methyl chanofruticosinate alkaloids from Kopsia arborea, Phytochemistry, 2008, 69, 558-561.
  45. K. H. Lim, O. Hiraku, K. Komiyama, and T. S. Kam, Jerantinines A G, Cytotoxic Aspidosperma Alkaloids from Tabernaemontana corymbosa, J. Natural Products, 2008, 71, 1591-1594.
  46. K. H. Lim, Y. Y. Low, G. H. Tan, T. M. Lim, and T. S. Kam, Kopsine and Danuphylline Alkaloids from Kopsia. Biomimetic Partial Synthesis of Danuphylline B, Helvetica Chimica Acta, 2008, 91, 1559-1566.
  47. S. H. Lim, K. Mahmood, K. Komiyama, and T. S. Kam, A Cycloartane Incorporating a Fused Tetrahydrofuran Ring and a Cytotoxic Lactam from Monocarpia marginalis, J. Natural Products, 2008, 71, 1104-1106.
  48. Siew-Huah Lim, Kamaliah Mahmood, Kanki Komiyama and Toh-Seok Kam, A Cycloartane Incorporating a Fused Tetrahydrofuran Ring and a Cytotoxic Lactam from Monocarpia marginalis, J. Nat. Prod. 2008, 71, 1104- 1106
  49. T. S. Kam, S. J. Tan, S. W. Ng, and K. Komiyama, Bipleiophylline, an Unprecedented Cytotoxic Bisindole Alkaloid Constituted from the Bridging of Two Indole Moities by an Aromatic Spacer Unit, Organic Letters, 2008, 10, 3749-3752.
  50. G. Subramaniam and T. S. Kam, Mersinaline and mersirachine, novel quinolinic alkaloids of the mersinine group from Kopsia, Tetrahedron Letters, 2007, 48, 6677-6680.
  51. G. Subramaniam, O. Hiraku, M. Hayashi, T. Koyano, K. Komiyama, and T. S. Kam, Biologically active aspidofractinine, rhazinilam, akuammiline, and vincorine alkaloids from Kopsia, J. Natural Products, 2007, 70, 1783-1789.
  52. K. H. Lim and T. S. Kam, Seco-leuconoxine and oxo-pericine derivatives from Kopsia, Helvetica Chimica Acta, 2007, 90, 31-35.
  53. K. H. Lim, K. Komiyama, and T. S. Kam, Arboricine and arboricinine, unusual tetracyclic indole regioisomers from Kopsia, Tetrahedron Letters, 2007, 48, 1143-1145.
  54. K. H. Lim, O. Hiraku, K. Komiyama, T. Koyano, M. Hayashi, and T. S. Kam, Biologically active indole alkaloids from Kopsia arborea, J. Natural Products, 2007, 70, 1302-1307.
  55. S. H. Lim, K. M. Sim, Z. Abdullah, O. Hiraku, M. Hayashi, K. Komiyama, and T. S. Kam, Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia, J. Natural Products, 2007, 70, 1380-1383.
  56. H. Hasegawa, Y. Yamada, K. Komiyama, M. Hayashi, M. Ishibashi, T. Yoshida, T. Sakai, T. Koyano, T. S. Kam, K. Murata, K. Sugahara, K. Tsuruda, N. Akamatsu, K. Tsukasaki, M. Masuda, N. Takasu, and S. Kamihira, Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells, Blood, 2006, 107, 607-688.
  57. K. H. Lim and T. S. Kam, Arboflorine, an Unusual Pentacyclic Monoterpenoid Indole Alkaloid Incorporating a Third Nitrogen Atom, Organic Letters, 2006, 8, 1733-1735.
  58. K. H. Lim and T. S. Kam, Arbophylline, a novel heptacyclic indole with a cage skeleton incorporating an acetal moiety, Tetrahedron Letters, 2006, 47, 8653-8655.
  59. K. H. Lim, Y. Y. Low, and T. S. Kam, Biomimetic Oxidative Transformations of Pericine: Partial Synthesis of Apparicine and Valparicine, a New Pentacyclic Indole Alkaloid from Kopsia, Tetrahedron Letters, 2006, 47, 5037-5039.
  60. T. S. Kam and G. Subramaniam, Mersilongine, an unusual tetracyclic, quinolinic, indole alkaloid from Kopsia, Tetrahedron Letters, 2004, 45, 3521-3524.
  61. T. S. Kam and H. S. Pang, Conodusarine, a new biologically active bisindole alkaloid from Tabernaemontana divaricata, Heterocycles, 2004, 63, 845-850.
  62. T. S. Kam and Y. M. Choo, Alkaloids from Alstonia angustifolia, Phytochemistry, 2004, 65, 603-608.
  63. T. S. Kam and Y. M. Choo, Angustilodine, an unusual pentacyclic indole from Alstonia, Helvetica Chimica Acta, 2004, 87, 366-369.
  64. T. S. Kam and Y. M. Choo, Kopsifolines A F, A new structural class of monoterpenoid indole alkaloids from Kopsia, Helvetica Chimica Acta, 2004, 87, 991-998.
  65. T. S. Kam and Y. M. Choo, New indole alkaloids from Alstonia macrophylla, J. Natural Products, 2004, 67, 547-552.
  66. T. S. Kam, G. Subramaniam, K. H. Lim, and Y. M. Choo, Mersicarpine, an unusual tetracyclic dihydroindole alkaloid incorporating a seven-membered imine ring, Tetrahedron Letters, 2004, 45, 5995-5998.
  67. T. S. Kam, K. H. Lim, K. Yoganathan, M. Hayashi, K. Komiyama, Lundurines A-D, cytotoxic indole alkaloids incorporating a cyclopropyl moiety from Kopsia tenuis and revision of the structures of tenuisines A-C, Tetrahedron, 2004, 60, 10739-10745.
  68. T. S. Kam, K. M. Sim, H. S. Pang, M. Hayashi, and K. Komiyama, Cytotoxic effects and reversal of multidrug resistance by ibogan and related alkaloids, Bioorganic and Medicinal Chemistry Letters, 2004, 14, 4487-4489.
  69. T. S. Kam, P. S. Pang, Y. M. Choo, and K. Komiyama, Biologically active ibogan and vallesamine derivatives from Tabernaemontana, Chemistry and Biodiversity, 2004, 1, 646-656.
  70. T. S. Kam, Y. M. Choo, and K. Komiyama, Unusual spirocyclic macroline alkaloids, nitrogenous derivatives, and a cytotoxic bisindole from Alstonia, Tetrahedron, 2004, 60, 3957-3966.
  71. T. S. Kam, and Y. M. Choo, Venalstonine and dioxokopsan derivatives from Kopsia, Phytochemistry, 2004, 65, 2119-2122.
  72. G. Subramaniam, T. S. Kam, and S. W. Ng, Mersinine A from Kopsia fruticosa, Acta Crystallographica, 2003, E59, o555-o557.
  73. K. Umezawa, A. Hiroki, M. Kawakami, H. Naka, I. Takei, T. Ogata, I. Kojima, T. Koyano, T. Kowithayakorn, H. S. Pang, and T. S. Kam, Induction of insulin production in rat pancreatic acinar carcinoma cells by conophylline, Biomedicine and Pharmacotherapy, 2003, 57, 341-350.
  74. T. S. Kam and K. M. Sim, Conodirinines A and B, novel vobasine-iboga bisindoles incorporating an additional tetrahydrooxacine unit on the vobasinyl moiety, Helvetica Chimica Acta, 2003, 86, 122-126.
  75. T. S. Kam and K. M. Sim, Conodurine, conoduramine and ervahanine derivatives from Tabernaemontana, Phytochemistry, 2003, 63, 625-629.
  76. T. S. Kam and Y. M. Choo, Kopsifolines A, B, and C, novel indole alkaloids with a hexacyclic carbon skeleton from Kopsia, Tetrahedron Letters, 2003, 44, 1317-1319.
  77. T. S. Kam and Y. M. Choo, Macrodasine A, a novel macroline derivative incorporating fused spirocyclic tetrahydrofuran rings containing a spiroacetal moiety, Tetrahedron Letters, 2003, 44, 8787-8789.
  78. T. S. Kam, H. S. Pang, and T. M. Lim, Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata, Organic and Biomolecular Chemistry, 2003, 1, 1292-1297.
  79. T. S. Kam, K. M. Sim, and H. S. Pang, New Bisindoles from Tabernaemontana corymbosa, J. Natural Products, 2003, 66, 11-16.
  80. T. S. Kam and K. M. Sim, Five New Iboga Alkaloids from Tabernaemontana corymbosa, J. Natural Products, 2002, 65, 669-672.
  81. T. S. Kam and K. M. Sim, New tabernamine derivatives from Tabernaemontana, Heterocycles, 2002, 57, 2137-2143.
  82. T. S. Kam and K. M. Sim, Vobasonidine and Vobatricine, Novel Bisindole Alkaloids from a Malayan Tabernaemontana, Helvetica Chimica Acta, 2002, 85, 1027-1032.
  83. T. S. Kam and K. M. Sim, Dippinines A - D, New Iboga-derived Alkaloids from Tabernaemontana, Heterocycles, 2001, 55, 2405-2412.
  84. T. S. Kam, G. Subramaniam, and T. M. Lim, Mersinines A and B and Mersiloscine, Novel Quinolinic Alkaloids from Kopsia, Tetrahedron Letters, 2001, 42, 5977-5980.
  85. T. S. Kam, K. M. Sim, and T. M. Lim, Voastrictine, a Novel Pentacyclic Quinolinic alkaloid from Tabernaemontana, Tetrahedron Letters, 2001, 42, 4721-4723.
  86. T. S. Kam, T. M. Lim, and G. H. Tan, Electrochemical Oxidation of Aspidofractinine-type Alkaloids: Formation of Kopsine, Kopsidine, Kopsinitarine, and Bisindole Derivatives, Journal of the Chemical Society, Perkin Transactions 1, 2001, 1594-1604.
  87. T. S. Kam and Y. M. Choo, Novel macroline-oxindoles from a Malayan Alstonia, Tetrahedron, 2000, 56, 6143-6150.
  88. T. S. Kam, K. M. Sim, and T. M. Lim, Tronocarpine, a novel pentacyclic indole incorporating a seven-membered lactam moiety, Tetrahedron Letters, 2000, 41, 2733-2736.
  89. M. C. Rho, M. Toyoshima, M. Hayashi, T. Koyano, G. Subramaniam, T. S. Kam and K. Komiyama, Reversal of Multidrug Resistance by Kopsiflorine from Kopsia dasyrachis, Planta Medica, 1999, 65, 307-310.
  90. T. S. Kam and K. M. Sim, Dippinine C, A New Hexacyclic Chippiine Derivative from a Malayan Tabernaemontana, Heterocycles, 1999, 51, 345-348.
  91. T. S. Kam and K.M. Sim, Dippinine A, A New Alkaloid of the Chippiine-type from a Malayan Tabernaemontana, Natural Product Letters, 1999, 13, 143-146.
  92. T. S. Kam, G. Subramaniam and W. Chen, Alkaloids from Kopsia dasyrachis, Phytochemistry, 1999, 51, 159-169.
  93. T. S. Kam, I. H. Iek and Y. M. Choo, Alkaloids from the stem-bark of Alstonia macrophylla, Phytochemistry, 1999, 51, 839-844.
  94. T. S. Kam, K. M. Sim, T. Koyano and K. Komiyama, Leishmanicidal alkaloids from Kopsia griffithii, Phytochemistry, 1999, 50, 75-79.
  95. T. S. Kam, T. M. Lim and G. H. Tan, Unprecedented cyanation and cyanomethylation following ring closure versus dimer formation in the anodic oxidation of the aspidofractinine alkaloid kopsamine, Heterocycles, 1999, 51, 249-253.
  96. T. S. Kam, T. M. Lim and Y. M. Choo, Structure and Biomimetic, Electrochemically-mediated Semisynthesis of the Novel Pentacyclic Indole Danuphylline, Tetrahedron, 1999, 55, 1457-1468.
  97. T. S. Kam, T. M. Lim, Y. M. Tee, G. Subramaniam and K. Yoganathan, 17-alpha-hydroxy-14,15-dehydrokopsinine and a bisindole alkaloid from a Malayan Kopsia, Phytochemistry, 1999, 50, 171-175.
  98. T. S. Kam, Y. M. Choo, W. Chen and J. X. Yao, Indole and monoterpene alkaloids from the leaves of Kopsia dasyrachis, Phytochemistry, 1999, 52, 959-963.
  99. C. H. Chuah, T. S. Kam and S. W. Ng, Crystal structure of N-methoxycarbonyl-11,12-methylenedioxy-16,17-dehydro-kopsinine, C24H26N2O6, Zeitschrift fur Kristallographie, 1998, 213, 163-165.
  100. S. L. Mok, K. Yoganathan, T. M. Lim and T. S. Kam, Cardiovascular Effects of Aspidofractinine-type Indole Alkaloids from Kopsia. J. Natural Products, 1998, 61, 328-332.
  101. T. S. Kam and G. Subramaniam, Oxo-derivatives of kopsine- and rhazinilam-type alkaloids from a North Borneo Kopsia, Natural Product Letters, 1998, 11, 131-136.
  102. T. S. Kam and K. M. Sim, Alkaloids from Kopsia griffithii, Phytochemistry, 1998, 47, 145-147.
  103. T. S. Kam, G. Subramaniam and W. Chen, 19(R)-Hydroxyeburnamine and 19(R)-hydroxyisoeburnamine from Kopsia dasyrachis, Natural Product Letters, 1998, 12, 293-298.
  104. T. S. Kam, G. Subramaniam, K. M. Sim, K. Yoganathan, T. Koyano, M. Toyoshima, M. C. Rho, M. Hayashi and K. Komiyama, Reversal of Multidrug Resistance (MDR) by Aspidofractinine-type Indole Alkaloids, Bioorganic and Medicinal Chemistry Letters, 1998, 8, 2769-2772.
  105. T. S. Kam, K. M. Sim, T. Koyano, M. Toyoshima, M. Hayashi and K. Komiyama, Conodiparines A-D, New bisindoles from Tabernaemontana. Reversal of vincristine-resistance with cultured cells, Bioorganic and Medicinal Chemistry Letters, 1998, 8, 1693-1696.
  106. T. S. Kam, K. M. Sim, T. Koyano, M. Toyoshima, M. Hayashi and K. Komiyama, Cytotoxic and leishmanicidal aminoglycosteroids and aminosteroids from Holarrhena curtisii, J. Natural Products, 1998, 61, 1332-1336.
  107. T. S. Kam, K. Yoganathan, K. Takahashi, T. Koyano and Kanki Komiyama, Lundurine B as a melanoma inhibitor, Japan Kokai, JP10045760, 1998.
  108. T. S. Kam, S. Anuradha, K. Takahashi, T. Koyano and K. Komiyama, Anticancer agents containing conofoline for treatment of multidrug-resistant tumours, Japan Kokai, JP10007567, 1998.
  109. T. S. Kam, S. Anuradha, T. M. Lim, K. Takahashi, T. Koyano and K. Komiyama, Conophylline quinone as a new antitumour agent, Japan Kokai, JP10045763, 1998.
  110. T. S. Kam, T. M. Lim, Y. M. Choo and G. Subramaniam, Danuphylline, a novel pentacyclic indole from Kopsia, Tetrahedron Letters, 1998, 39, 5823-5826.
  111. T. S. Kam, Y. M. Tee and G. Subramaniam, Rhazinal, a formylrhazinilam derivative from a Malayan Kopsia, Natural Product Letters, 1998, 12, 307-310.
  112. W. Chen, S. Anuradha and T. S. Kam, Crystal structure of conofoline, Zeitschrift fur Kristallographie, 1998, 213, 183-184.
  113. T. S. Kam and K. Yoganathan, Lahadinines A and B, new cyano-substituted indole alkaloids from Kopsia pauciflora, Phytochemistry, 1997, 46, 785-787.
  114. T. S. Kam and K. Yoganathan, Nitaphylline, a new bisindole alkaloid from Kopsia, Natural Product Letters, 1997, 10, 69-74.
  115. T. S. Kam, K. T. Nyeoh, K. M. Sim and K. Yoganathan, Alkaloids from Alstonia scholaris, Phytochemistry, 1997, 45, 1303-1305.
  116. T. S. Kam, K. Yoganathan and C. H. Chuah, Four heptacyclic indoles from Kopsia teoi, Phytochemistry, 1997, 45, 623-625.
  117. T. S. Kam, K. Yoganathan and Chen Wei, Monoterpene alkaloids from Kopsia pauciflora, J. Natural Products, 1997, 60, 673-676.
  118. T. S. Kam, K. Yoganathan and S. L. Mok, Aspidofractinine alkaloids from Kopsia teoi, Phytochemistry, 1997, 46, 789-792.
  119. T. S. Kam, K. Yoganathan, H. Takahashi, T. Koyano and K. Komiyama, Pauciflorines A and B as melanin formation inhibitors, Japan Kokai, JP09255683, 1997.
  120. T. S. Kam, K. Yoganathan, H. Y. Li and N. Harada, Tenuisines A - C and Tenuiphylline, novel bisindoles from Kopsia tenuis, Tetrahedron, 1997, 53, 12661-12670.
  121. T. S. Kam, R. Jayashankar, K. M. Sim and K. Yoganathan, Angustimaline, an unusual nitrogenous compound from Alstonia angustifolia, Tetrahedron Letters, 1997, 38, 477-478.
  122. A. Ali, G. B. Gill, G. Pattenden, G. A. Roan and T. S. Kam, Palladium and Cobalt Mediated cyclizations of Halo-Polyenes: A Comparative Study, J. Chem. Soc., Perkin Trans. 1, 1996, 1081-1093.
  123. J. S. L. Mok, K. Yoganathan and T. S. Kam, Testing for antihypertensive activities of kopsingine and its congenors in spontaneously hypertensive rats, Asia Pacific Journal of Pharmacology, 1996, 11, Suppl. 1, S19.
  124. T. S. Kam and K. Yoganathan, Three Aspidofractinine Alkaloids from Kopsia, Phytochemistry, 1996, 42, 539-541.
  125. T. S. Kam, K. Yoganathan and Chen Wei, Kinabalurine A, a new monoterpene alkaloid from Kopsia, Natural Product Letters, 1996, 8, 231-235.
  126. T. S. Kam, K. Yoganathan and Chen Wei, Novel cage indoles from a Malaysian Kopsia, J. Natural Products, 1996, 59, 1109-1112.
  127. T. S. Kam, K. Yoganathan and Chen Wei, Paucidactine A and B, new indole alkaloids with a novel ring system containing a lactone moiety, Tetrahedron Letters, 1996, 37, 3603-3606.
  128. T. S. Kam, K. Yoganathan and H. Y. Li, Tenuisines A, B and C, Novel bisindoles with C2 symmetry from Kopsia tenuis, Tetrahedron Letters, 1996, 37, 8811-8814.
  129. T. S. Kam, K. Yoganathan, T. Koyano and K. Komiyama, Pauciflorine A and B, Novel Melanin Biosynthesis Inhibitors from Kopsia, Tetrahedron Letters, 1996, 37, 5765-5768.
  130. T. S. Kam, Lalitha Arasu and K. Yoganathan, Alkaloids from the stem of Kopsia pauciflora, Phytochemistry, 1996, 43, 1385-1387.
  131. T. S. Kam, S. Anuradha and K. Y. Loh, Voafinidine and voalenine, novel indoles of the aspidosperma-type from Tabernaemontana, Natural Product Letters, 1996, 8, 49-53.
  132. T. S. Kam and P. S. Tan, Dehydropleiocarpine alkaloids from Kopsia profunda, Phytochemistry, 1995, 39, 469-471.
  133. T. S. Kam and S. Anuradha, Alkaloids from Tabernaemontana divaricata, Phytochemistry, 1995, 40, 313-316.
  134. T. S. Kam and S. Anuradha, Voafinine and N-methylvoafinine, novel aspidosperma alkaloids from Tabernaemontana, Natural Product Letters, 1995, 7, 191-195.
  135. T. S. Kam, K. Yoganathan and C. H. Chuah, Lundurines A, B and C, new indole alkaloids with a novel carbon skeleton containing a cyclopropyl moiety, Tetrahedron Letters, 1995, 36, 759-762.
  136. T. S. Kam, K. Yoganathan and W. H. Wong, Novel cage indole alkaloidal artefacts containing an alpha-aminoketone moiety from a Kopsia species, Natural Product Letters, 1995, 5, 309-314.
  137. T. S. Kam, T. M. Lim and G. H. Tan, Electrochemical oxidation of aspidofractinine-type alkaloids. A facile electrochemically-mediated conversion of kopsingine to kopsidines A, B, C and kopsinganol, Tetrahedron Letters, 1995, 36, 1327-1330.
  138. T. S. Kam, K. Yoganathan, C. H. Chuah, Kopsinitarines A, B and C, novel cage alkaloids from a Malaysian Kopsia, Tetrahedron Letters, 1994, 35, 4457-4460.
  139. M. C. R. Symons, T. S. Kam, J. Wyatt and T. M. Lim, Electron paramagnetic resonance studies of electron-capture processes. p-Nitrobenzyl and p-nitrobenzylidene systems, J. Chem. Soc., Perkin Trans. 2, 1993, 151-155.
  140. T. S. Kam and K. Y. Loh, 5-oxo-19,20-dehydroervatamine from the leaves of Tabernaemontana corymbosa, Phytochemistry, 1993, 32, 1357-1358.
  141. T. S. Kam and T. M. Lim, Electron-transfer versus nucleophilic substitution in the reactions of alpha-halogenated 4-nitrotoluenes with base, J. Chem. Soc., Perkin Trans. 2, 1993, 147-150.
  142. T. S. Kam, K. Y. Loh and Chen Wei, Conophylline and conophyllidine: new dimeric alkaloids from Tabernaemontana divaricata, J. Natural Products, 1993, 56, 1865-71.
  143. T. S. Kam, K. Yoganathan and C. H. Chuah, Kopsidine A and Kopsidine B, two novel indole alkaloids from a Malaysian Kopsia, Tetrahedron Letters, 1993, 34, 1819-1822.
  144. T. S. Kam, K. Yoganathan, C. H. Chuah and Chen Wei, Aspidofractinine alkaloids from a new Kopsia species, Phytochemistry, 1993, 32, 1343-1346.
  145. T. S. Kam, P. S. Tan and Chen Wei, Absolute configuration of C-16 of eburnane alkaloids from Kopsia larutensis, Phytochemistry, 1993, 33, 921-924.
  146. T. S. Kam, P. S. Tan, P. Y. Hoong and C. H. Chuah, Methyl chanofruticosinates from the leaves of Kopsia arborea, Phytochemistry, 1993, 32, 489-491.
  147. J. Mok, P. Chang, K. H. Lee, T. S. Kam and S. H. Goh, Cardiovascular responses in the normotensive rat produced by intravenous injection of gambirine isolated from Uncaria callophylla, J. Ethnopharmacol., 1992, 36, 219-223.
  148. S. H. Goh, T. S. Kam, K. H. Lee, J. S. L. Mok and S. L. Oo, A study of the Malaysian medicinal plant Uncaria callophylla, Asean J. Sci. Technol. Develop., 1992, 9 (1): 117-125.
  149. T. S. Kam, K. H. Lee, S. H. Goh, Alkaloid distribution in Malaysian Uncaria, Phytochemistry, 1992, 31, 2031-2034.
  150. T. S. Kam, K. Y. Loh, L. H. Lim, W. L. Loong, C. H. Chuah and Chen Wei, New alkaloids from Tabernaemontana divaricata, Tetrahedron Letters, 1992, 33, 969-972.
  151. T. S. Kam, P.S. Tan, C.H. Chuah, Alkaloids from the leaves of Kopsia larutensis, Phytochemistry, 1992, 31, 2936-2938.
  152. T. S. Kam, K. H. Lee, S. H. Goh, Dimeric indole alkaloids from Uncaria callophylla, Phytochemistry, 1991, 30, 3441-3444.
  153. T. S. Kam and P. S. Tan, Plumeran alkaloids from Kopsia profunda, Phytochemistry, 1990, 29, 2321-2322.
  154. S. H. Goh, F. L. Lai and T. S. Kam, Vitamin E concentrate from palm fatty acid distillate, Malaysian Patent, P. I. No. 8703215 (1989).
  155. Y. M. Choo, A. S. H. Ong, S.H. Goh, T. S. Kam, Recovery of carotenoids, tocopherols, tocotrienols and sterols from esterified palm oil, UK Patent, GB 2218989 (1989).
  156. S. H. Goh and T. S. Kam, Comparative reactivity of substituted 4-nitrobenzylidene dichlorides with alkali, J. Chem. Soc., Perkin Trans. 1, 1981, 423-426.
  157. S. H. Goh and T. S. Kam, Kinetics and mechanism of the reaction of 4-nitrobenzylidene dichloride with hydroxide ion, J. Chem. Soc., Perkin Trans. 2, 1978, 648-652.
  158. S. H. Goh, K. C. Chan, T. S. Kam, and H. L. Chong, Dihalocarbene insertions into carbon-hydrogen bonds of hydrocarbons and ethers, Aust. J. Chem., 1975, 28, 381-384.
Chapter in Books
  1. T. S. Kam and K. H. Lim, Alkaloids of Kopsia. In The Alkaloids: Chemistry and Biology; G. A. Cordell, Ed.; Academic Press: The Netherlands, 2008; Vol. 66, pp. 1 111.
  2. T. S. Kam and Y. M. Choo, Bisindole Alkaloids, in The Alkaloids. Chemistry and Biology, G. A. Cordell (Ed.), Elsevier Inc., 2006, Volume 63, Chapter 4, pp. 181-337.
  3. T. S. Kam, Alkaloids from Malaysian Flora, in Alkaloids: Chemical and Biological Perspectives, S. W. Pelletier (Ed.), Pergamon, Amsterdam, 1999, Volume 14, Chapter 2, pp. 285-435.
  4. S. H. Goh, K. H. Lee, T. S. Kam and E. Soepadmo, Rutin and alkaloids in Malaysian Uncaria in Flavonoids in Biology and Medicine Das, N. P. (Ed.), 1989, National University of Singapore.
Article in Proceeding
  1. T. S. Kam, A synthesis of Z -11-hexadecenol, Z -11-hexadecenal, and Z -11-hexadecenyl acetate, the major components of the sex pheromone of Plutella xylostella, Malaysian Chemical Congress, Kuala Lumpur, 1989, p.6.

RESEARCH INTEREST

  • Bioorganic
  • Medicinal Chemistry
  • Natural Product

RESEARCH PROJECT

National
  1. 2011 - 2015, High Impact Research (HIR)
    Biorganic and Medicinal Chemistry and Organic Synthesis ( Principal Investigator(PI))
  2. 2011 - 2012, High Impact Research (HIR)
    Structure, Synthesis, and Evaluation of Bioactive Secondary Metabolites from Plants and Microbes ( Principal Investigator(PI))
  3. 2009 - 2012, Geran Penyelidikan Universiti Malaya (UMRG)
    Synthesis and Evaluation of Bioactive Indole, Bisindole, and Oligostibenoid Derivatives ( Principal Investigator(PI))
  4. 2009 - 2010, ScienceFund
    Development of biologically active secondary metabolites from microorganisms for potential applications in pharmacotherapy ( Principal Investigator(PI))
  5. 2009 - 2010, Fundamental Research Grant Scheme (FRGS)
    Electrochemical oxidation of stilbenes, xanthones and allyl phenols: Investigation of mechanisms and applications in synthesis ( Principal Investigator(PI))
  6. 2008
    Biological Activity of Alkaloids and other secondary metabolites with special emphasis on Cancer
  7. 2008
    Biomimetic Synthesis of Indole Derivatives
  8. 2008
    Electroorganic Chemistry of Indole Derivatives
  9. 2008
    Natural Product Chemistry with special emphasis on Alkaloids
  10. 2007 - 2008, Fundamental Research Grant Scheme (FRGS)
    Investigations of the role of Iminium ions as Key Intermediates in Indole Alkaloid Transformations ( Principal Investigator(PI))
  11. 2007 - 2008, ScienceFund
    Development, Synthesis, and Evaluation of Bioactive Indole Derivatives for Potential Applications in Biomedicine and Pharmacotherapy ( Principal Investigator(PI))
  12. 2005 - 2007, ASM/SAGA
    Biomimetic synthesis of novel indole alkaloids from Kopsia and Tabernaemontana ( Principal Investigator(PI))
  13. 2003 - 2005, MOSTI/IRPA
    Development, synthesis, and evaluation of new chemosensitizers for reversal of multidrug resistance ( Principal Investigator(PI))
  14. 2003 - 2005, MOSTI/IRPA
    Electrochemical reactions and synthesis of bioactive heterocyclic derivatives ( Principal Investigator(PI))
  15. 1997 - 2000, MOSTI/IRPA
    Development of New Raw Materials for Novel Pharmaceuticals ( Principal Investigator(PI))
  16. 1996 - 1999, MOSTI/IRPA
    Electroorganic Synthesis and Mechanisms ( Principal Investigator(PI))
  17. 1991 - 1995, MOSTI/IRPA
    Chemical Investigations of Malaysian Plants for Bioactive Substances ( Principal Investigator(PI))
  18. 1989 - 1994, AIDAB
    Development of Therapeutic Substances from Plants (International) Asean-Australian Economic Cooperation Program (AAECP) Biotechnology Project ( Consultant)
  19. 1989 - 1990, MOSTI/IRPA
    Chemical Investigations of Malaysian Plants for Cytotoxic and Antihypertensive Constituents ( Principal Investigator(PI))

CONSULTANCY PROJECT

  • Identification, Analysis, and Advising On An Unknown Compound Found in Musim Mas' Crude Palm Oil Fraction, P.T. Musim Mas
    01 Dec 2015 - 01 Dec 2015 (International)

SUPERVISION

Postgraduate Student
Master
  1. (2005) Biomimetic Partial Synthesis of Some Indole Derivatives, Low Yun Yee