Curriculum Vitae

DR. TAN SOON HAO

Senior Lecturer
  • Department of Biomedical Science
    Faculty of Medicine

AREAS OF EXPERTISE

  • HISTOPATHOLOGY, IMMUNOHISTOCHEMISTRY, IN SITU HYBRIDISATION, TEM, IMMUNO-FLUORESCENCE (IF)
  • VIROLOGY

ACADEMIC QUALIFICATION

  • PHD, (Philosophy)
    Universiti Malaya (UM)
  • SARJANA MUDA SAINS (KEPUJIAN) SAINS BIOPERUBATAN, (Biomedical Science)
    Universiti Tunku Abdul Rahman (Utar)

ADMINISTRATIVE DUTIES

  • AHLI UNIT IUFOM
    03 Apr 2023 - 31 Dec 2024 (Department of Biomedical Science, Faculty of Medicine)
  • Course Coordinator
    01 Oct 2023 - 03 Mar 2024 (Department)
  • MIC2027 HUMAN PATHOLOGY
    01 Oct 2023 - 03 Mar 2024 (Department)
  • MIC2002 Pathology for Biomedical Science
    01 Oct 2023 - 03 Mar 2024 (Department)
  • AHLI JAWATANKUASA KURIKULUM
    01 Jan 2023 - 31 Dec 2023 (Department)
  • DEPUTY QUALITY MANAGER
    01 Jan 2023 - 31 Dec 2023 (Department)
  • YEAR 1 COORDINATOR
    01 Jan 2023 - 31 Aug 2023 (Department of Biomedical Science, Faculty of Medicine)
  • MIC1015 HISTOLOGICAL TECHNIQUES IN BIOMEDICAL SCIENCE
    13 Mar 2023 - 23 Jul 2023 (Department)
  • MIC 2009 HISTOLOGICAL TECHNIQUES IN BIOMEDICAL SCIENCE
    13 Mar 2023 - 23 Jul 2023 (Department)
  • MIC1013 HUMAN BODY SYSTEM II
    13 Mar 2023 - 23 Jul 2023 (Department)
  • Programme Coordinator
    01 Sep 2022 - 31 Dec 2022 (Department of Biomedical Science, Faculty of Medicine)
  • Course Coordinator
    22 Aug 2019 - 31 Dec 2022 (Department)
  • Quality Manager
    05 Sep 2021 - 06 Sep 2022 (Department)
  • Coordinator
    01 Jan 2022 - 31 Aug 2022 (Department of Biomedical Science, Faculty of Medicine)
  • Course Coordinator
    10 Oct 2021 - 13 Mar 2022 (Department)
  • Deputy Quality Manager
    12 Mar 2018 - 31 Dec 2021 (Department of Biomedical Science, Faculty of Medicine)
  • PENYELARASAN KURSUS STUDENT HOLISTIC EMPOWERMENT (SHE)
    22 Aug 2019 - 31 Dec 2021 (Department of Biomedical Science, Faculty of Medicine)
  • Coordinator for MIC2009
    08 Mar 2021 - 18 Jul 2021 (Department of Biomedical Science, Faculty of Medicine)
  • Course Coordinator for MIC2009 Histological Techniques in Biomedical Science
    05 Feb 2018 - 31 Jul 2020 (Department of Biomedical Science, Faculty of Medicine)
  • AJK Semakan Kurikulum Program Sains Bioperubatan
    01 Jan 2019 - 01 Jan 2020 (Department of Biomedical Science, Faculty of Medicine)
  • Course Coordinator for MIC2002 Pathology for Biomedical Science
    03 Sep 2018 - 17 Feb 2019 (Department of Biomedical Science, Faculty of Medicine)

MEMBERSHIPS

  • INTERNATIONAL SOCIETY FOR INFECTIOUS DISEASES, MEMBERSHIP
    Since 2018 (International)

AWARD AND STEWARDSHIP

  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2022 (University)
  • 1st prize in International Convention of Forensic Medicine and Science 2022
    MASFORMS, 2022 (International)
  • Silver medal
    ITEX 2022, 2022 (International)
  • SILVER MEDAL (SENIOR INNOVATOR) IN MALAYSIA INVENTION AND INNOVATION EXPO 2022
    MALAYSIA INVENTION AND INNOVATION EXPO 2022 , 2022 (International)
  • SILVER Medal Award
    Centre for Automotive Engineering Universiti Malaysia Pahang, 2021 (International)
  • SILVER AWARDS
    Malaysia Technology Expo 2021, 2021 (International)
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2021 (University)
  • Champion of Poster Presentation
    10th Malaysian Symposium of Biomedical Science, 2019 (National)
  • Best Poster Presenter
    10th Malaysian Symposium of Biomedical Science, 2019 (National)
  • 1st Runner Up of Poster Presentation
    10th Malaysian Symposium of Biomedical Science, 2019 (National)
  • Faculty of Medicine Award, Best Publication in Basic Neuroscience
    Faculty of Medicine, University of Malaya, 2018 (University)
  • HFMD2016 conference, Travel Grant Award, Singapore
    A*STAR, 2016 (International)
  • Best Publication Award 2014
    Malaysian Society of Neurosciences (MSN) , 2015 (National)

PUBLICATIONS

Article in Journal
WoS
  1. Yap, Hui-Yeng Y.; Rosli, Mohammad Farhan Ariffeen; Tan, Soon-Hao; Kong, Boon-Hong; Fung, Shin-Yee (2023). The Wound Healing Potential of Lignosus rhinocerus and Other Ethno-myco Wound Healing Agents, MYCOBIOLOGY. 51(1), 1-15. doi:10.1080/12298093.2022.2164641
  2. Ohka, Seii; Tan, Soon Hao; Ishiyama, Eri; Ogasawara, Katsutoshi; Hanasaka, Tomohito; Ishida, Kinji; Hagiwara, Kyoji; Liu, Chia-Chyi; Chong, Pele Choi-Sing; Hanaki, Ken-ichi; Schiavo, Giampietro (2022). The uncoating of EV71 in mature late endosomes requires CD-M6PR, BIOLOGY OPEN. 11(9). doi:10.1242/bio.059469
  3. Ohka, Seii; Tan, Soon Hao; Kaneda, Shohei; Fujii, Teruo; Schiavo, Giampietro (2022). Retrograde axonal transport of poliovirus and EV71 in motor neurons, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 626, 72-78. doi:10.1016/j.bbrc.2022.08.015
  4. Wong, K. T.; Ong, K. C.; Ng, K. Y.; Ng, C. W.; Tan, S. H.; Teo, W. L.; Karim, N.; Kumar, S. (2022). Neuronal infection is a major pathogenetic mechanism and cause of fatalities in human acute Nipah virus encephalitis, NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY. 48(6). doi:10.1111/nan.12828
  5. Wong, K. T.; Tan, S. H.; Jayanthi, J.; Liew, J. W. K.; Ong, K. C.; Lau, Y. L.; Lucas, S.; Hiu, J. (2022). In situ hybridisation to detect and identify Plasmodium parasites in human malaria, HISTOPATHOLOGY. 81, 163-163
  6. Yap, Hui Yeng Yeannie; Kong, Boon Hong; Yap, Chee Sum Alvin; Ong, Kien Chai; Zain, Rosnah Binti; Tan, Soon Hao; Zaini, Zuraiza Mohamad; Ng, Szu Ting; Tan, Chon Seng; Fung, Shin Yee (2022). Immunomodulatory Effect and an Intervention of TNF Signalling Leading to Apoptotic and Cell Cycle Arrest on ORL-204 Oral Cancer Cells by Tiger Milk Mushroom, Lignosus rhinocerus, FOOD TECHNOLOGY AND BIOTECHNOLOGY. 60(1), 80-88. doi:10.17113/ftb.60.01.22.7296
  7. Abd Raziff, H. H., Tan, D., Tan, S. H., Wong, Y. H., Lim, K. S., Yeong, C. H., . . . Ahmad, H. (2021). Laser-heated needle for biopsy tract ablation: In vivo study of rabbit liver biopsy. Physica Medica-European Journal of Medical Physics, 82, 40-45. doi: 10.1016/j.ejmp.2021.01.067
  8. Ang, W. X., Sarasvathy, S., Kuppusamy, U. R., Sabaratnam, V., Tan, S. H., Wong, K. T., . . . Ong, K. C. (2021). In vitro antiviral activity of medicinal mushroom Ganoderma neo-japonicum Imazeki against enteroviruses that caused hand, foot and mouth disease. Tropical Biomedicine, 38(3), 239-247. doi: 10.47665/tb.38.3.063
  9. Lalani, S., Tan, S. H., Tan, K. O., Lim, H. X., Ong, K. C., Wong, K. T., & Poh, C. L. (2021). Molecular mechanism of L-SP40 peptide and in vivo efficacy against EV-A71 in neonatal mice. Life Sciences, 287, 11. doi: 10.1016/j.lfs.2021.120097
  10. Tan, D., Lim, K. S., Wong, Y. H., Abd Raziff, H. H., Tan, S. H., Sulaiman, N., . . . Yeong, C. H. (2021). Multivariate Regression Between Hounsfield Unit Shift, Tissue Temperature, and Tissue Contraction: A Feasibility Study of Computed Tomography Thermometry. Ieee Transactions on Instrumentation and Measurement, 70, 9. doi: 10.1109/tim.2021.3075019
  11. Udos, W., Ooi, C. W., Tan, S. H., Lim, K. S., Ee, Y. J., Ong, K. C., & Ahmad, H. (2021). Label-free surface-plasmon resonance fiber grating biosensor for Hand-foot-mouth disease (EV-A71) detection. Optik, 228, 7. doi: 10.1016/j.ijleo.2020.166221
  12. Hooi, Y. T., Ong, K. C., Tan, S. H., Perera, D., & Wong, K. T. (2020). A novel orally infected hamster model for Coxsackievirus A16 hand-foot-and-mouth disease and encephalomyelitis. Laboratory Investigation, 100(9), 1262-1275. doi: 10.1038/s41374-020-0456-x
  13. Hooi, Y. T., Ong, K. C., Tan, S. H., Perera, D., & Wong, K. T. (2020). Coxsackievirus A16 in a 1-Day-Old Mouse Model of Central Nervous System Infection Shows Lower Neurovirulence than Enterovirus A71. Journal of Comparative Pathology, 176, 19-32. doi: 10.1016/j.jcpa.2020.02.001
  14. Hooi, Y. T.; Ong, K. C.; Tan, S. H.; Perera, D.; Wong, K. T. (2020). Coxsackievirus A16 in a 1-Day-Old Mouse Model of Central Nervous System Infection Shows Lower Neurovirulence than Enterovirus A71, JOURNAL OF COMPARATIVE PATHOLOGY. 176, 19-32. doi:10.1016/j.jcpa.2020.02.001
  15. Yu, S. P., Ong, K. C., Tan, S. H., Perera, D., & Wong, K. T. (2020). Japanese encephalitis virus: Biological clones from a clinical isolate quasispecies show differing neurovirulence in vitro and in a mouse model. Neurology Asia, 25(3), 279-284.
  16. Fu, T. L., Ong, K. C., Tan, S. H., Wong, K. T. (2019). Japanese Encephalitis Virus Infects the Thalamus Early Followed by Sensory-Associated Cortex and Other Parts of the Central and Peripheral Nervous Systems. Journal of Neuropathology and Experimental Neurology, 78(12), 1160-1170. doi:10.1093/jnen/nlz103
  17. Yee, P. T. I., Tan, S. H., Ong, K. C., Tan, K. O., Wong, K. T., Hassan, S. S., Poh, C. L. (2019). Development of live attenuated Enterovirus 71 vaccine strains that confer protection against lethal challenge in mice. Scientific Reports, 9, 15. doi:10.1038/s41598-019-41285-z
Others
  1. Tan SH, Ong KC, Perera D, Wong KT. 2016. A monoclonal antibody to ameliorate central nervous system infection and improve survival in a murine model of human Enterovirus-A71 encephalomyelitis. Antiviral Research. 132: 196-203.

RESEARCH PROJECT

National
  1. 2022 - 2025, Fundamental Research Grant Scheme (FRGS)
    Signal Enhancement Study For Gold-coated Tilted Grating With Streptavidin-biotin Sandwich Assay In The Detection Of Sars-cov-2 Virus ( Co-Researcher)
  2. 2020 - 2024, Fundamental Research Grant Scheme (FRGS)
    The Molecular Basis Of Retrograde Axonal Transport In Enterovirus A71 (ev-a71) Neuroinvasion ( Co-Researcher)
  3. 2020 - 2022, RU Geran
    Japanese Encephalitis: Viral Genomic Neurovirulence Determinants And The Role Of Peripheral Sensory Nerves In Neuroinvasion ( Principal Investigator(PI))
  4. 2019 - 2021, Others MOHE - Top 100 (IIRG)-HWB
    Characterization And Evaluation Of Tfbg Biosensor To Detect Enteroviruses Associated With Hand-foot-and Mouth Disease ( Principal Investigator(PI))
  5. 2017 - 2020, Bantuan Kecil Penyelidikan (BKP)
    Screening of several potential local natural products as prophylaxis against Hand Foot and Mouth Disease. ( Principal Investigator(PI))
  6. 2017 - 2019, Prototype Research Grant Scheme (PRGS)
    Laser Ablation Needle for Tissue Cauterization and Percutaneous Hyperthermia Cancer Therapy ( Consultant)
International
  1. 2018 - 2025, International Funding
    The Effect Of Orally-administered Anti-enterovirus A71 Agents To Reduce Viral Shedding And To Treat Infection And Its Complications ( Principal Investigator(PI))
  2. 2022 - 2024, International Funding
    Characterizing The Epidemiological Diversity Of Nipah Strains ( Co-Researcher)

PAPER PRESENTED

INVITED SPEAKER
  1. Neuronal infection in the central nervous system by intracerebrally-inoculated Enterovirus A71 does not occur directly but via retrograde axonal transport in peripheral nerves, Academia Sinica-Malaysian Universities Academic Symposium , Academia Sinica, Taiwan (International) (02 Jun 2019 - 04 Jun 2019)
ORAL PRESENTER
  1. Neuroinvasion via peripheral nerves: Increasing evidence for its importance in viral encephalitis, 19th International Congress of Neuropathology , International Congress of Neuropathology (ICN) (International) (23 Sep 2018 - 27 Sep 2018)
POSTER PRESENTER
  1. A Japanese encephalitis virus quasispecies with an E gene mutation exhibits reduced neurovirulence, 19th International Congress of Neuropathology, International Congress of Neuropathology (ICN) (International) (23 Sep 2018 - 27 Sep 2018)
  2. Sensory nervous system involvement in a footpad-inoculated, Japanese encephalitis mouse model, 19th International Congress of Neuropathology, International Congress of Neuropathology (ICN) (International) (23 Sep 2018 - 27 Sep 2018)
  3. Enterovirus A71 neuronal infection in an intracerebrally-inoculated mouse model occurs mainly via peripheral nerves and not by direct infection or cell-to cell viral spread., Hand, Foot and Mouse Disease International Conference 2016, A*Star (International) (25 Jul 2016 - 26 Jul 2016)
  4. Enterovirus 71 infection of the brainstem via cranial nerves can be ameliorated by passive immunization, XVIII International Congress of Neuropathology, International Society of Neuropathology (International) (14 Sep 2014 - 18 Sep 2014)
  5. hSCARB2-dependent neural pathway for EV71 transmission., 18th International Picornavirus Meeting, European Study Group on the Molecular Biology of Picornaviruses (International) (10 Mar 2014 - 14 Mar 2014)
  6. Cranial nerves are involved in viral entry into the brainstem in a mouse model of Enterovirus 71 encephalomyelitis, 10th European Congress of Neuropathology, The European Confederation of Neuropathological Societies (Euro-CNS) and the British Neuropathological Society (BNS) (International) (06 Jun 2012 - 09 Jun 2012)
  7. Enterovirus 71 infection in the mouse and hamster as models for viral myositis studies, The 9th Annual Asian and Oceanian Myology Center (AOMC) Scientific Meeting, Asian and Oceanian Myology Center (International) (25 Mar 2010 - 26 Mar 2010)
OTHERS
  1. Insights on neuroinvasion and neurovirulence from a footpad-inoculated mouse model of Japanese encephalitis, 108th Annual Meeting of the Japanese Soc of Pathology 2019, Japanese Society of Pathology (International) (09 May 2019 - 11 May 2019)
  2. DEVELOPMENT OF AN IN SITU HYBRIDIZATION ASSAY FOR THE DETECTION OF ZIKA VIRUS RNA IN FORMALIN-FIXED AND PARAFFIN-EMBEDDED TISSUES, 10th Malaysian Symposium of Biomedical Science, USM (National) (26 Apr 2019 - 28 Apr 2019)
  3. Characterization of a Mouse Monoclonal IgM Antibody against Enterovirus A71, 10th Malaysian Symposium of Biomedical Science, USM (National) (26 Apr 2019 - 28 Apr 2019)

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ACADEMIC/PROF. SERVICES

Evaluation
  1. (2022) Panel Reviewer for Umsc Ca.R.E Fund Research Grant 2022, University, (Internal Evaluator)
  2. (2021) Masters Candidature Defense for Ms. Ainur Azmira Binti Zainuddin , (Internal Examiner)
  3. (2018) PhD candidature defence for Yu Shu Pin, Department of Pathology, University of Malaya , (Candidature defense)
  4. Reviewer for Asia Pacific Journal of Molecular Biology and Biotechnology, (Reviewer)
  5. PhD candidature defence for Hooi Yuan Teng, Department of Pathology, University of Malaya , (Candidature defense)
  6. PhD proposal defence for Tan Pak Kheong, Department of Biomedical Science, University of Malaya , (proposal defence)
  7. PhD candidature defence for Fu Tzeh Long, Department of Pathology, University of Malaya , (Candidature defense)
  8. PhD candidature defence for Tan Jia Shin Jessica, Department of Pathology, University of Malaya , (Candidature defense)
  9. Internal Examiner: DOCTORAL THESIS (RESEARCH MODE), (Internal Examiner)
Contribution to external organisation
  1. ( ) Workshop on real-time RT-PCR & Western blot analysis 2019 , UM

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2020) TILTED FIBER BRAGG GRATING(TFBG) BIOSENSOR FOR HAND FOOT MOUTH DISEASE(HFMD) DIAGNOSIS, Ooi Cheong Weng
  2. (2020) natural products, alternative medicine, Mohammad Farhan Ariffeen Bin Rosli
Master
  1. (2020) DEVELOPMENT OF BROAD-SPECTRUM ANTIVIRAL AGENT(S) AGAINST ENTERVIRUSES THAT CAUSED HAND, FOOT AND MOUTH DISEASE., ang wei xin
  2. (2019) Evaluation of Malaysian Plants for Properties against Hand, Foot and Mouth Disease (HFMD), MUNIRA BT MOHAMED HAMIDI
Under Graduate Students
  1. (2019) Enterovirus A71 5 UTR Secondary Structure: Its relationship with AIM2 inflammasome expression in neuronal cells.
  2. (2018) Investigation of Japanese Encephalitis virus and Dengue virus infection and replication in neuronal and non-neuronal cells.
  3. (2018) DEVELOPMENT OF AN IN SITU HYBRIDIZATION ASSAY FOR THE DETECTION OF ZIKA VIRUS RNA IN FORMALIN-FIXED AND PARAFFIN-EMBEDDED TISSUES
  4. (2018) CHARACTERIZATION OF A MOUSE MONOCLONAL IgM ANTIBODY AGAINST ENTEROVIRUS A71

TEACHING

Master
  1. (2019) MIC3004 - Cytology for Biomedical Science
Bachelor
  1. (2021) MIX2001 - Applications in Biomedical Science
  2. (2021) MIC2009 - Histological Techniques in Biomedical Science
  3. (2021) MIC1009 - Human Body Systems I
  4. (2021) MIC2002 - Pathology for Biomedical Science
  5. (2019) MIC2002 - Pathology for Biomedical Science
  6. (2019) MIC2009 - Histological Techniques in Biomedical Science
  7. (2019) MIC4001 - Research Design in Biomedical Science
  8. (2019) MIC4006 - Laboratory Management and Quality Control
  9. (2018) MIC2002 - Pathology for Biomedical Science
  10. (2018) MIC2009 - Histological Techniques in Biomedical Science
  11. (2017) MIC2002 - Pathology for Biomedical Science

SOCIAL RESPONSIBILITY ACTIVITIES

  • Science Outreach: Kuen Cheng High School, (22 Jun 2019 - 22 Jun 2019)
  • Science Outreach Programme: Sekolah Kebangsaan Pulau Meranti, (18 Jun 2019 - 18 Jun 2019)
  • Committee Member of Malaysian Brain Bee Challenge Zone C 2019, (18 Mar 2019 - 18 Mar 2019)
  • Science Outreach Programme, (02 Jul 2018 - 31 Dec 2018)