Curriculum Vitae

PROF. DR. TAN NGET HONG

Honorary Professor
  • Department of Molecular Medicine
    Faculty of Medicine
  • tannh
  • +60379674912

AREAS OF EXPERTISE

  • BIOPHARMACEUTICALS
    Bioactive substances in tiger milk mushroom
  • MEDICAL EDUCATION AND STUDENT SURVEY
    Medical Education, Student Survey
  • TOXINOLOGY OF SNAKE VENOMS
  • PROTEIN PURIFICATION TECHNOLOGY
  • ENZYMOLOGY

ACADEMIC QUALIFICATION

  • PhD(University of Chicago)1976, (Bioorganic Chemistry)
    Universityof Chicago, Chicago
  • MSc(University of Chicago)(1974), (BIOORGANIC CHEMISTRY)
    Universityof Chicago, Chicago
  • BSc(National Taiwan University)1972, (Chemistry)
    National Taiwan University, Taipei

ADMINISTRATIVE DUTIES

  • Ahli J/K Kurikulum
    01 Mar 2008 - 30 Jun 2016 (Faculty)
  • AJK Pengarang Journal of the University of Malaya Medical Center
    01 Mar 2008 - 01 Aug 2013 (Faculty)

AWARD AND STEWARDSHIP

  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2015 (University)
  • Science and Technology Award
    Malaysian Toray Science Foundation (MTSF), 2009 (International)
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2005 (University)
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2002 (University)
  • EXCELLENCE SERVICE AWARD
    University of Malaya, 1995 (University)
  • 14th International Union of Biochemists Travel Fellowship
    International Union of Biochemists, 1988 (International)
  • Asean Regional Fellowship
    Mahidol University, Thailand, 1981 (International)

PUBLICATIONS

Article in Journal
  1. Chong, H.P., Tan, K.Y., Tan, N.H. and Tan, C.H. (2019). Exploring the diversity and novelty of toxin genes in Naja sumatrana, the Equatorial spitting cobra from Malaysia, through de novo venom-gland transcriptomics. Toxins:11, 104. doi:10.3390/toxins11020104
  2. Fung, S.Y., Cheong, Peter C.H., Tan, N.H., Ng, S.T. and Tan, C.S. (2019) Nutritional evaluation on Lignosus cameronensis C.S.Tan. A Medicinal Polyporaceae.. Intn Union of Biochem and Mol Bio Life Article DOI: 10.1002/iub.2006. Article number IUB2006.
  3. Oh, Angeline, M.F., Quraishi, N.A. and Tan, C.H. (2019). Venom proteome of Bungarus sindanus (Sind krait) from Pakistan and in vivo cross-neutralization of toxicity using an Indian polyvalent antivenom. J. Proteomics 193: 243-254, https://doi.org/10.1016/j.jprot.2018.10.016
  4. Tan , K.Y., Liew, J.L., Tan, N.H., Quah, E.S.H., Ismail, A.K. and Tan, C.H. (2019) Unlocking the secrets of banded coral snake (Calliophis intetinalis, Malaysia): A venom with proteome novelty, low toxicity and stealthy antigenicity. J Proteomics. 2019, 192: 246-257 doi: 10.1016/j.jprot.2018.09.006.
  5. Tan, C.H., Tan, K.Y., Ng, T.S., Quah, E.S.H., Ismail, A.K., Komvilai, S., Siprija, V., Tan, N.H. (2019). Venomics of Trimeresurus (Popeia) nebularis, the Cameron Highlands pit viper from Malaysia: Insights into venom proteome, toxicity and neutralization by antivenom. Toxins, 11, 95; doi:10.3390/toxins11020095
  6. Tan, C.H., Wong, K.Y., Tan, N.H., Ng T.S. and Tan, K.Y. (2019). Discinctive distribution of secretory phospholipase A2 in the venoms of Afro-Asian cobras (subgenus: Naja, Afronaja, Boulengerina and Uraeus). Toxins, 11, 116; doi:10.3390/toxins11020116
  7. Tan, K.Y., Liew, S.T., Tan, Q.Y., Izzati, A.N., Nadhirah, A.F., Liew, J.L., Sim, S.M., Tan, N.H., Khomvilai, S., Sitprija, V. and Tan, C.H. (2019). Evaluating the physicochemical properties and efficacy of recently expired and aged antivenom products from Thailand and Taiwan. Toxicon 160, 55-58
  8. Faisal, T., Tan, C.H., Tan, K.Y., Sim, S.M., Quraishi,N. and Tan, N.H. (2018). Proteomics, Functional Characterization and Antivenom Neutralization of the Venom of Pakistani Russell's Viper (Daboia russelii) from the Wild. J Proteomics 183: 1-13.
  9. Fung, S.Y., Cheong, P.C.H., Tan, N.H., Ng, S.T. and Tan, C.S. (2018). Nutrient and chemical analysis of the fruiting body of a cultivar of the Chinese Caterpillar Mushroom. Int. J. Med. Mushrooms, 20(5), 459-469, DOI: 10.1615/IntJMedMushrooms.2018026252
  10. Fung, S.Y., Lee, M.L., Tan, N.H. (2018). Proteomic investigation of the molecular mechanism of king cobra venom L-amino acid oxidase induced apoptosis of human breast cancer (MCF-7) cell line. Indian J. Exp. Biol. 56, 101-111.
  11. Tan, C.H., Tan, K.Y., Ng, T.S., Sim, S.M., Kwong, K.O. and Tan, N.H. (2018). Venom proteome of spine-bellied sea snake (Hydrophis curtus) from Penang, Malaysia: Toxicity correlation, immunoprofiling and cross-neutralization by Sea Snake Antivenom. Toxins, 11(1), pii E3; doi:10.3390/toxins11010003
  12. Tan, K. Y., Tan, N. H., & Tan, C. H. (2018). Venom proteomics and antivenom neutralization for the Chinese eastern Russell s viper, Daboia siamensis from Guangxi and Taiwan. Scientific Reports, 8(1), 8545.
  13. Wong, K. Y.; Tan, C. H.; Tan; Tan, K. Y.; Quraishi, N. H.; Tan, N. H. (2018) Elucidating the biogeographical variation of the venom of Naja naja (spectacled cobra) from Pakistan through a venom-decomplexing proteomic study. J Proteomics. 175, 156-173.
  14. Yennie, HY Yap, N.H. Tan, S.T. Ng, C.S. Tan and Fung, S.Y. (2018). Inhibition of protein glucation by Tiger Milk Mushroom (Lignosus rhinocerotis Cooke Ryvarden) and search for potential anti-dibetic activity related metabolic pathways by genomic and transcriptomic data mining. Frontiers in Pharmacology, 2018 Feb 14;9:103. doi: 10.3389/fphar.2018.0010
  15. Yennie, Yap, H.Y., Tan, N.H., Ng, S.T., Tan, C.S. and Fung, S.Y. (2018). Molecular attributes and apotosis-inducing activtiies of a putative serine protease isolated from Tiger Milk Mushroom (Lignosus rhinoceros) sclerotium against breast cancer cells in vitro. Peer J. 6: e4940
  16. Angeline M.F. Oh, C.H. Tan, G.C. Ariaranee, N. Quraishi, N.H. Tan (2017). Venomics of Bungarus caeruleus (Indian krait): Comparable venom profiles but variable immunoreactivities among specimens from Sri Lanka, India and Pakistan. J Proteomics104, 1-18.
  17. Fung, S.Y., Lee, S.S., Tan, N.H., Pailoor, J. (2017). Safety assessment of cultivated fruiting body of Ophiocordyceps sinensis evaluated through subacute toxicity in rats. Journal of Ethnopharmacology 206:236-244
  18. Ratanabanangkoon, K., Simsiriwong, P., Pruksaphon, K., Tan, K.Y., Eursakun, S., Tan, C.H., Chantrathonkul, B., Wongwadhunyoo, W., Youngchim, S., Tan, N.H. (2017). A novel in vitro potency assay of antisera against Naja kaouthia based on nicotinic acetylcholine receptor binding. Sci Rep.7, 8545
  19. Shin Yee Fung, Sook Shien Lee, Nget Hong Tan, Jayalakhsmi Pailoor (2017). Safety evaluation of sclerotium from a medicinal mushroom, Lignosus cameronensis (cultivar): Preclinical toxicology studies, Frontiers in Pharmacology; 8: 594. doi: 10.3389/fphar.2017.00594
  20. Tan C.H., Tan, K.Y., Yap, M.K.K., Fung, S.Y. and Tan, N.H. (2017). Venomics of Tropidolaemus wagleri, the sexually dimorphic temple pit viper: Unveiling a deeply conserved atypical toxin arsenal" Sci Reports, 7:43237,DOI: 10.1038/srep43237.
  21. Tan KY, Tan CH, Lawan, C., Fung SY and Tan, N.H. (2017). Comparative venom gland transcriptomics of Naja kaouthia (monocled cobra) from Malaysia and Thailand: Elucidating geographical venom variations and sequence novelty. PeerJ, 5,e3142; DOI 10.7717/peerj.3142
  22. Tan, C.H., Liew, J.L., Tan, N.H., Khaldun, I.A., Maharani, T., Khomvilai, S., Sitprija, V. (2017). Cross reactivity and lethality neutralization of venoms of Indonesian Trimeresurus complex species by Thai Green pit viper antivenom. Toxicon, 140:32-37.
  23. Tan, C.H., Wong, K.Y., Tan, K.Y. and Tan, N.H. (2017). The venom proteme of the yellow-lipped sea krait, Laticauda colubrine from Bali: Insights into subvenomic diversity, venom antigenicity and cross-neutralization by antivenom. J Proteomics, 166, 48-58; doi: 10.1016/j.prot.2017.07.002
  24. Tan, C.H., Wong, K.Y., Tan, K.Y., Naeem, Q.H., Tan, N.H. (2017). Elucidating the biogeographical variation of the venom of Naja naja (spectacled cobra) from Pakistan through a venom-decomplexing proteomic study. J proteomic. doi.org/10.1016/j.jprot.2017.12.012
  25. Tan, N.H., Wong, K.Y. and Tan, C.H. (2017). Venomics of Naja sputatrix, the Javan spitting cobra: a short neurotoxin-driven venom that needs antivenom improvement for neutralization. J Proteomics 157, 18-32.
  26. Yap, H.Y.Y., Muria-Gonzalez, M.J., Kong, B.H., Stubbs, K.A., Tan, C.S., Ng, S.T., Tan, N.H., Solomon, P.S., Fung, S.Y., Chooi, Y.H. (2017).Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast. Microbial Cell Factories 16:103
  27. 172.Vigneshraaj, P., Fatima, A., Chong, C.H., Thandeka, V.A., Ng, S.T., Tan, C.S., Fung, S.Y., Tan, N.H. and Lim, R.I.H. (2016). Characterization of a new fungal immunomodulatory protein from tiger milk mushroom, Lignosus rhinocerotis. Scientific Reports. Accepted for publication.
  28. 7.Tan, K.Y., Tan, C.H., Fung, S.Y. and Tan, N.H. (2016). Neutralization of the principal toxins from the venoms of Thai Naja kaouthia and Malaysian Hydrophis schistosus: Insights into toxin-specific neutralization by two different antivenoms. Toxins (2016), 8, 86.
  29. Boon-Hong Kong, Nget-Hong Tan, Shin-Yee Fung,Jayalakshmi Pailoor, Chon-Seng Tan and Szu- Ting Ng. 2015. Nutritional composition, antioxidant properties and toxicology evaluation of the sclerotium of Tiger Milk Mushroom Lignosus tigris cultivar E, Nutrition Research 36: 174-183.
  30. Esther Tang, L.H., Tan, C.H., Fung, S.Y. and Tan, N.H. (2016). The venomics of Calloselasma rhodosoma, the Malayan pit viper: A complex toxin arsenal unraveled. J. Proteomics. 148:44-56.doi: 10.1016/j.jprot.2016.07.006.
  31. Kong, B.H., Tan, N.H., Fung, S.Y. and Jayalakshmi, P. (2016). Evaluation of the sub-acute toxicity of the Tiger Milk mushroom Lignosus tigris cultivar E sclerotium in Sprague Dawley rats. Frontiers Pharmacology 7:246. doi: 10.3389/fphar.2016.00246
  32. Ratanabanangkoon, K., Tan, K.Y., Earsakul, S., Watcharatanyatip, K., Sintiprungrat, K., Tan, C.H., Pamornsakda, T. and Tan, N.H. (2016). A novel strategy for the production of a pan-specific antiserum against elapids of Asia. PloS Negl.Trop.Dis. 10: e0004565
  33. Tan, C. H.; Liew, J. L.; Tan, K. Y.; Tan, N. H. (2016) Genus Calliophis of Asiatic coral snakes: A deficiency of venom cross-reactivity and neutralization against seven regional elapid antivenoms. Toxicon 121:130-133.
  34. Tan, C.H., Fung, S.Y., Yap, M.K.K., Leong, P.K., Liew, J.L. and Tan, N.H. (2016). Unveiling the elusive and exotic: Venomics of the Malayan blue coral snake (Calliophis bivirgata flaviceps). J Proteomics. 132:1- 12. doi: 10.1016/j.jprot.2015.11.014.
  35. Tan, C.H., Liew, J.L., Tan, K.Y. and Tan, N.H. (2016). Assessing SABU (Serum Anti Bisa Ular), the sole Indonesian antivenom: a proteomic analysis and in vivo venom neutralization study. Scientific Reports. 6:37299.
  36. Tan, CH, Tan, K.Y. and Tan, N.H. (2016). Revisiting Notechis scutatus venom: On shotgun proteomics and neutralization by the bivalent Sea Snake Antivenom. J. Proteomics. 144, 33-38; doi: 10.1016/j.jprot.2016.06.004
  37. Tan, K.Y., Tan, C.H., Sim. S.M., Fung, S.Y. and Tan, N.H. (2016). Geographical Venom Variations of the Southeast Asian Monocled Cobra (Naja kaouthia): Venom- Induced Neuromuscular Depression and Antivenom Neutralization. Comp Biochem Physiol (C).186C, 77-86
  38. Wong, K.Y., Tan, C.H. and Tan, N.H. (2016). Venom and purified toxins from the spectacled cobra (Naja naja) of Pakistan. Insights into the toxicity and antivenom neutralization. Am J Trop Med Hyg. 94, 1392-1399.
  39. Fung, S.Y., Lee, M.L. and Tan, N.H. (2015). Molecular mechanism of cell death induced by king cobra (Ophiophagus hanah) venom L-amino acid oxidase. Toxicon 96: 38-45.
  40. Leong, P.K., Fung, S.Y., Tan, C.H., Sim, S.M. and Tan, N.H. (2015) Immunological cross-reactivity and neutralization of the principal toxins of Naja sumatrana and related cobra venoms by a Thai polyvalent antivenom (Neuro Polyvalent Snake Antivenom).Acta Tropica (2015), 149, pp. 86-93.
  41. Sapsutthipas, S., Leong, P.K., Akesowan, S., Pratanaphon, R., Tan, N.H. and Ratanabanangkoon, K. (2015): Effective equine immunization protocol for production of potent poly-specific antiserum against Calloselasma rhodostoma, Cryptelytrops albolabris and Daboia siamensis. PlosNTD DOI:10.1371/journal.pntd.0003609
  42. Tan C.H., Tan, N.H., Sim, S.M., Fung, S.Y. and Gnanathasan, C.A. (2015). Proteomic investigation of Sri Lankan hump-nosed pit viper (Hypnale hypnale) venom. Toxicon 93:164-170. DOI: 10.1016/j.toxicon.2014.11.231
  43. Tan, C.H., Tan, K.Y., Fung, S.Y. and Tan, N.H. (2015). Venom-gland transcriptome and venom proteome of Malaysian king cobra (Ophiophigus hannah): unravelling the toxins variations. BMC Genomics 16, 687
  44. Tan, C.H., Tan, N.H., Tan, K.Y. and Kwong, K.O. (2015). Antivenoms cross-neutralization of the venoms of Hydrophis schistosus and Hydrophis curtus, two common sea snakes in the Malaysian waters. Toxins, 2015, 7: 572-581. doi:10.3390/toxins7020572
  45. Tan, K.Y., Tan, C.H. Fung, S.Y. and Tan, N.H. (2015). Venomics, lethality and neutralization of Naja kaouthia (monocled cobra) venoms from three different geographical regions of Southeast Asia. J. Proteomics, 120:105-125. doi: 10.1016/j.jprot.2015.02.012
  46. Tan, N.H., Fung, S.Y., Tan, K.Y., Yap, M.K.K., Gnanathasan, C.A. and Tan C.H. (2015). Functional venomics of the Sri Lankan Russell s viper (Dabois russelii) venom and its toxinological correlations. J. Proteomics 128:403-23. doi: 10.1016/j.jprot.2015.08.017.
  47. Yap, M.K.K., Tan, N.H., Sim, S.M., Fung, S.Y. and Tan , C.H. (2015). The effect of a polyvalent antivenom on the serum venom antigen levels of Naja sputatrix (Javan spitting cobra) venom in experimentally envenomed rabbits. Basic Clin Pharmacol Toxicol. doi: 10.1111/bcpt.12398
  48. Yap, Y.H.Y., Fung, S.Y., Ng, S.T., Tan, C.S. and Tan,N.H.(2015): Genome-Based Proteomic Analysis of Lignosus rhinocerotis (Cooke) Ryvarden sclerotium. Int J Med Sci.12(1): 23-31
  49. Yap, Y.HY, Chooi, YH, Fung, S.Y., Ng, S.T., Tan, C.S. and Tan, N.H. (2015). Transcriptome analysis revealed highly expressed genes encoding secondary metabolite pathways and small cysteine-rich proteins in the sclerotium of Lignosus rhinocerotis. PloS One,10, E0143549
  50. Yap, Y.HY, Fung, S.Y., Ng, S.T., Tan, C.S. and Tan, N.H. (2015). Shotgun proteomic analysis of tiger milk mushroom (Lignosus rhinocerotis) and the isolation of a cytotoxic fungal serine protease from its sclerotium. J. ethnopharmacology 174, 437-451.
  51. Fung, S.Y., Sim, S.M., Jeyaseelan, K., Armugam, A., Aguiyi, J.C. and Tan, N.H. (2014). The prophylactic effect of Mucuna pruriens Linn (velvet bean) seed extract against experimental Naja sputatrix envenomation: Gene expression studies. Indian J Exp Biology, 52(9):849-59.
  52. Lee, M.L., Chung, I., Fung, S.Y., Kanthimathi, M.S. and Tan, N.H. (2014). Antiproliferative activity of king cobra (Ophiophagus Hannah) venom L-amino acid oxidase. Basic and Clinical Pharmacology and Toxicology (2014) 114, 336-343. doi: 10.1111/bcpt.12155.
  53. Lee, M.L., Fung, S.Y., Chung, I., Pailoor, J., Cheah, S.H., Tan, N.H. (2014) King cobra (Ophiophagus hannah) venom L-amino acid oxidase induces apoptosis in PC-3 cells and suppresses PC-3 solid tumor growth in a tumor xenograft mouse model. Intn J Medical Sci 11, 593-601
  54. Lee, S.S., Tan, N.H., Fung, S.Y., Sim, S.M. Tan, C.S. and Ng, S.T. (2014). Anti-inflammatory effect of the sclerotium of Lignosus rhinocerotis (Cooke) Ryvarden, the Tiger Milk Mushroom. BMC Complementary and Alternative Medicine, 14: 359. DOI: 10.1186/1472-6882-14-359
  55. Leong, P.K., Tan, C.H., Sim, S.M., Fung, S.Y., Sumana, K., Sitprija, V. and Tan, N.H. (2014). Cross neutralization of common Southeast Asian viperid venoms by a Thai polyvalent antivenom (Hemato Polyvalent Snake Antivenom). Acta Tropica.132, 7-14. DOI:10.1016/j.actatropica.2013.12.015
  56. Tan, C.H., Sim, S.M., Gnanathasan, C.A., Fung, S.Y., Tan, N.H. (2014) Pharmacokinetics of the Sri Lankan hump-nosed pit viper (Hypnale hypnale) venom following intravenous and intramuscular injections of the venom into rabbits, Toxicon 79, 37-44 http://dx.doi.org/10.1016/j.toxicon.2013.12.011
  57. Yap, M.K.K., Tan, N.H., Sim, S.M., Fung, S.Y. and Tan, C.H. (2014). Pharmacokinetics of Naja sumatrana (Equatorial spitting cobra) venom and its major toxins in experimentally envenomed rabbits. Plos NTD. 8, e2890
  58. Yap, MKK, Fung, S.Y., Tan, K.Y. and Tan, N.H. (2014). Proteomic characterization of venom of the medically important Southeast Asian Naja sumatrana (Equatorial spitting cobra). Acta Tropica. 133 (2014), pp. 15-25. DOI information: 10.1016/j.actatropica.2014.01.014
  59. Yap, Y.H.Y., Azlina, A.A., Fung, S.Y., Ng, S.T., Tan, C.S. and Tan, N.H. (2014). Nutrient composition, antioxidant properties, and anti- inflammatory activity of wild type and cultivated strain of Lignosus tigeris. Int J Med Sci 11:602-607
  60. Yap, Y.HY, Chooi, YH, Firdaus-Raih, M., Fung, S.Y., Ng, S.T., Tan, C.S. and Tan, N.H. (2014). The genome of the Tiger Milk Mushroom, Lignosus rhinocerotis, provides insights into the geneic basis of its medicinal properties. BMC Genomics.2014, 15:635 DOI: 10.1186/1471-2164-15-635
  61. Yap, Yeannie H.Y., Fung, S.Y., Tan, N.H., Ng, S.T. and Tan, C.S. (2014). DNA barcode markers for two new species of tiger milk mushrooms: Lignosus tigris C.S.Tan and Lignosus cameronensis C.S. Tan. Intn. J. Agric. Biol.16, 841-844.
  62. Fung, S.Y. and Tan, N.H. (2013). Isolation, characterization and antigenic cross-reactivities of the major hemorrhagin from Cryptelytrops purpureomaculatus venom. Ind J Exp Biol, 51, 1063-1069
  63. Lee, S.S., Enchang, F.K., Tan, N.H., Fung, S.Y. and Pailoor, J. (2013). Preclinical toxicological evalutions of the sclerotium of Lignosus rhinocerus (Cooke), the Tiger Milk Mushroom. J. ethnopharmacoly. 147, 157-163
  64. Sim, S.M., Saremi, K., Tan, N.H. and Fung, S.Y. (2013) . Pharmacokinetics of Cryptelytrops purpureomaculatus (mangrove pit viper) venom following intravenous and intramuscular injections in rabbits. Intn. Immunopharmacol. 17, 997-1001
  65. Yap, Michelle K.K., Tan, N.H., Sim, S.M. and Fung, S.Y. (2013). Toxicokinetics of Naja sputatrix (Javan spitting cobra) venom following intramuscular and intravenous administrations of the venom into rabbits. Toxicon 68, 18-23
  66. Yap, Yeannie H.Y., Tan, N.H., Fung, S.Y., Aziz, A.A., Tan, C.S. and Ng, S.T. (2013). Nutrient composition, antioxidant properties and anti-proliferative activity of Lignosus rhinocerus Cooke sclerotium. J. Sc. Food Agric. DOI 10.1002/jsfa.6121
  67. Choo Hock Tan,Nget Hong Tan, Si Mui Sim, Shin Yee Fung, Pailoor Jayalashmi, Christeine Ariaratnam Gnanathasan. 2012. Nephrotoxicity of hump-nosed pit viper (Hypnale hypnale) venom in mice is preventable by the paraspecific Hemato polyvalent antivenom (HPA). Toxicon, 60:1259-1262
  68. Fung, S.Y., Tan, N.H., Sim, S.M. and Aguiyi, J.C. (2012). Effect of Mucuna pruriens seed extract pretreatment on the responses of spontaneously beating rat atria and aortic ring to Naja spuatrix (Javan spitting cobra) venom. Evidence-based Complementary and Alternative Medicine. doi:10.1155/2012/486390.
  69. Lee, M.L., Tan,N.H., Fung, S.Y., Tan, C.S. and Ng, S.T. (2012) The anti-proliferative activity of sclerotia of Lignosus rhinocerus (tiger milk mushroom). Evidence-based Complementary and Alternative Medicine. Vol 2012, ID 697603. Doi. 10.1155/2012/697603
  70. Leong, P.K., Sim, S.M., Fung, S.Y., Sumana, K., Sitprija, V. Tan, N.H. (2012). Cross neutralization of Afro-Asian cobra and Asian krait venoms by a Thai polyvalent snake antivenom (Neuro polyvalent snake antivenom). PloS Neglected Tropical Diseases, 6, e1672.
  71. Leong, P.K., Tan, N.H., Fung, S.Y. and Sim, S.M. (2012). Cross neutralization of Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms. Trans Royal Soc Tropical Med. http://dx.doi.org/10.1016/j.trstmh.2012.07.009.
  72. Tan, C.H., Tan, N.H.,Sim, S.M., Fung, S.Y. and Gnanathasan, C.A. (2012). Immunological properties of Hypnale hypnale (hump-nosed pit viper) venom: Antibody production with diagnostic and therapeutic potentials. Acta Tropica, 122, 267-275.
  73. Tan, N.H. Fung, S.Y. and Yeannie Yap H.Y. (2012). Isolation and characterization of the thrombin-like enzyme from Cryptelytrops albolabris (white-lipped tree viper) venom. Comp. Biochem. Physiol. B. 161, 79- 85.
  74. Fung, S.Y., Tan, N.H., Sim, S.M., Marinello, E. , Guerranti, R. and Aguiyi, J.C. (2011). Mucuna pruriens Linn. Seed extract pretreatment protects against cardiorespiratory and neuromuscular depressant effects of Naja sputatrix (Javan spitting cobra) venom in rats. Indian Journal of Experimental Biology. 49, 254- 259
  75. Lee, ML., Tan, N.H., Fung, S.Y. and Shamala, D.S> (2011) Antibacterial action of a heat-stable form of L- amino acid oxidase isolated from king cobra (Ophiophagus hannah) venom. Comp. Biochem. Physiol. C, 153, 237-242.
  76. Lee, S.S. Tan, N.H., Fung, S.Y., Pailoor J. and Sim, S.M. (2011). Evluation of the sub-acute toxicity of the sclerotium of Lignosus rhinocerus (Cooke) the Tiger Milk mushroom. J.Ethnopharmacology 138, 192-200
  77. Tan, C.H., Fung, S.Y. Ponnudurai, G., Ariaratnam, C.A., Sim, S.M., Tan, N.H. (2011). Enzymatic and toxinological activities of Hypnale hypnale (hump- nosed pit viper) venom and its fractionation by ion exchange high performance liquid chromatography. J. Venom. Anim. Toxins Incl. Trop.Med. 17:4, 473-485
  78. Tan, C.H., Leong, P.K., Fung, S.Y., Sim, S.M., Ponnudurai, G., Ariaratnam, C. Khomvilai, S., Sitprija, V. and Tan, N.H. (2011). Cross neutralization of Hypnale hypnale (hump-nosed pit viper) venom by polyvalent and monovalent Malayan pit viper antivenoms in vitro and in a rodent model. Acta Tropica (2011) 117, 119-124.
  79. Yap, M.K.K., Tan, N.H. and Fung, S.Y. (2011) Biochemical and toxinological characterization of Naja sumatrana (Equatorial spitting cobra) venom. J. Venom. Anim. Toxins Incl. Trop.Med. 17. 17, 451-459
  80. Fung, S.Y., Tan, N.H. and Sim, S.M. (2010). Protective effects of Mucuna pruriens seed extract pretreatment against cardiovascular and respiratory depressant effects of Calloselasma rhodostoma (Malayan pit viper) venom in rats. Tropical Biomedicine, 27(3), 366-372.
  81. NH Tan (2010) Isolation and characterization of the thrombin-like enzyme from Cryptelytrops purpureomaculatus venom. Comp. Biochem. Physiology, Part C, 151, 131-136.
  82. Tan, N.H., Fung, S.Y. and Ponnudurai, G. (2010). Enzymatic and immunological properties of Bungarus flaviceps (red-headed krait) venom. J. Venom. Anim. Toxins Incl. Trop.Med. 16, 147-154
  83. Fung, S.Y., Tan, N.H., Liew, S.H., Sim, S.M., and Aguiyi, J.C. 2009. The protective effects of Mucuna pruriens seed extract against histopathological changes induced by Malayan cobra venom in rats. Tropical Biomedicine.26(1), 80-84
  84. Tan, N.H., Ponnudurai, G. and Fung, S.Y. 2009. Serum kinetics of Calloselasma rhodostoma venom components in rabbit. J. Venom. Anim. Toxins incl. Trop. Med.. 15 (2), 340-346.
  85. Tan, N.H., Sim, S.M., Fung, S.Y., Marinello, Guerranti, R., Aguiyi, J.B. (2009). The protective effect of Mucuna pruriens seeds against snake venom poisoning. J. Ethanopharmacology. 123. 356-358.
  86. Tan, N.H., Fung, S.Y., Sim, S.M., Marinello, E., Guerranti, R. and Aguiyi, J.C. (2008). The protective effect of Mucuna pruriens seed against cobra venom poisoning: immunological studies. Journal of the FEBS. P432.
  87. Tan, NH, Fung, S., Marinello, E., Guerranti, R., Jeyaseelan, K, Armugam, A and Aguiyi, J (2007) The protective effect of Mucuna pruriens seed against cobra venom poisoning: gene expression studie. The FEBS Journal 274S, 298
  88. Azila NMA, Tan NH and Tan CPL. (2006) Inducing curricular change: Initial evaluation of outcomes. Medical Education 40, 1123-1147
  89. Sim, S.M., Azila, N.M.A., Lay, H.L., Tan, C.P.L. and Tan, N.H. 2006. A simple instrument for the assessment of student performance in Problem-based learning tutorials. Annals Academy of Medicine Singapore. Vol 35, p 634-641.
  90. Tan, N.H., Ponnudurai, G. and Chung, M.C. (2005). Studies on the epitopes of Malayan pit viper venom hemorrhagin. The FEBS Journal, 272, Supplement 1. pp.394.
  91. Marinello E, Guerranti R, Pagani R, Aguiyi JC, Tan NH, Fung SY, "Immunological cross-reactions between snake venoms and anti-Mucuna pruriens IgG", 2004, Eur J Biochem, Vol. 271, no. s1, pg. 106
  92. Azila NMA, Tan NH, Sim SM, Rosnah I, Liam CK and Atiya AS, "Critical thinking development in a hybrid problem based learning programme", 2003, J Med Educ, Vol. 7, pg. 306-312
  93. Azila NMA, an CPL, Sim SM, Tan NH, Atiya AS and Junedah S, "Problem based learning: Monitoring and searching for an appropriate tune", 2002, J Med Educ, Vol. 6, pg. 68-73
  94. Azila, N.M.A., Tan, N.H. and Kwan, C.Y. 2002. Quality assurance in problem-based learning. J. Medi. Edu. 6, 1-2
  95. Tan NH and Fung SY, "A hemorrhagic toxin from the venom of Trimeresurus purpureomaculatus venom", 2002, Eur J Biochem, Vol. 269, pg. 99
  96. Tan, N.H. 2010. Isolation and characterization of the thrombin-like enzyme of Cryptelytrops purpureomaculatus venom. Comparative Biochemistry and Physiology, Part C. 151, 131-136.
  97. Jeyaseelan K, Armugam A, Donghui Ma and Tan NH, "Structure and phylogeny of venom group I phospholipase A", 2000, Mol Biol Evol, Vol. 17, pg. 1010-1021
  98. Chuman, Y., Nobuhisa, I., Ogawa, T., Deshimaru, M., Chijiwa, T., Tan, N.H., Fakumaki, Y., Shimohigashi, Y., Ducancel, F., Boulain, J.C., Menez, A. and Ohno, M. (1999): Regional and accelerated molecular evolution in group I snake venom gland phospholipase A isoenzymes. Toxicon 38, 449-462.
  99. Afifiyan, F., Armugam, A., Gopalakrishnakone, P., Tan, N.H., Tan, C.H. and Jeyaseelan, K. 1998: Four new postsynaptic neurotoxins from Naja naja sputatrix venom: cDNA cloning, protein expression and phylogenetic analysis. Toxicon 36, 1871-1876.
  100. Jeyaseelan, K., Armugam, A., Lachumanan, R., Tan, C.H. and Tan, N.H. (1998): Six isoforms of cardiotoxin in Malayan spitting cobra (Naja naja sputatrix) venom: Cloning and characterization of cDNAs. Biochim. Biophys. Acta 1380, 209-222.
  101. Armugam, A., Earnest, L., Chung, M.C.M., Gopalakrishnakone, P., Tan, C.H., Tan, N.H. and Jeyaseelan, K. 1997. Cloning and characterization of cDNAs encoding three isoforms of phospholipase A in Malayan spitting cobra (Naja naja sputatrix) venom. Toxicon 35, 27-37.
  102. Tan, N.H., Gnanajothy, P. and Chung, M.C.M. 1997.: Proteolytic specificity of rhodostoxin, the major hemorrhagin of Calloselasma rhodostoma (Malayan pit viper) venom. Toxicon 35, 979-984.
  103. Chung, M.C.M., Gnanajothy, P., Kataoka, M., Shimizu, S. and Tan, N.H. 1996. Structural studies of a major hemorrhagin (rhodostoxin) from the venom of Calloselasma rhodostoma (Malayan pit viper). Arch. Biochem. Biophys. 325, 199-208
  104. Daltry, J.C., Gnanajothy, P., Chai, K.S., Tan, N.H., Thorpe, R.S. and Wolfgang, W. (1996): Electrophoretic profiles and biological activities: Intraspecific variation in the venom of the Malayan pit viper (Calloselasma rhodostoma). Toxicon 34, 67-69.
  105. Tan, N.H. and Gnanajothy, P. 1996. The toxinology of Calloselasma rhodostoma (Malayan pit viper) venom. Toxin Reviews 15, 1-17.
  106. Chung, M.C.M., Tan, N.H. and Arunmozhiarasi, A. 1994. The amino acid sequence of two postsynaptic neurotoxins isolated from Malayan cobra (Naja naja sputatrix) venom. Toxicon 32, 1471-1474.
  107. Gnanajothy, P., Chung, M.C.M. and Tan, N.H. 1994. Purification and properties of the L-amino acid oxidase from Malayan pit viper (Calloselasma rhodostoma) venom. Arch. Biochem. Biophys. 313, 373-78.
  108. Tan, N.H. and Gnanajothy, P. (1994): An investigation on the antigenic cross-reactivity of Calloselasma rhodostoma (Malayan pit viper) venom hemorrhagin, thrombin-like enzyme and L-amino acid oxidase using enzyme-linked immunosorbent assay. Toxicon, 32, 1265-1269.
  109. Tan, N.H., Choy, S.K., Chin, K.M. and Gnanajothy, P. 1994.Cross-reactivity of monovalent and polyvalent Trimeresurus antivenoms with venoms from various species of Trimeresurus (lance-headed pit viper) snake. Toxicon, 32, 849-853
  110. Gnanajothy, P., Chung, M.C.M. and Tan, N.H. 1993.Isolation and characterization of a hemorrahgin from the venom of Calloselasma rhodostoma (Malayan pit viper). Toxicon, 31, 997-1005
  111. Tan, N.H., Gnanajothy P. and Mirtschin, P.J. 1993. A comparative study on the biological properties of venoms from juvenile and adult common tiger snake (Notechis scutatus) venoms. Comp. Biochem.Physiol. 106B, 651-654
  112. Tan, N.H., Gonanajothy, P. and Mirtschin, P. 1993. A comparative study of the biological properties of venoms from juvenile and adult inland taipan (Oxyuranus microlepidotus) snake venoms. Toxicon, 31, 363-368
  113. Tan, N.H., Lim, K.K. and Nik Jaafar, M.I. 1993. An investigation on the antigenic cross-reactivity of Ophiophagus Hannah (king cobra) venom neurotoxin, phospholipase A, hemorrhagin and L-amino acid oxidase using enzyme-linked immunosorbent assay. Toxicon, 31, 865-72.
  114. Tan, N.H. and Gnanajothy, P. 1992. A comparative study on the electrophoretic patterns of snake venom. Comp. Biochem. Physiol. 102B, 103-110.
  115. Tan, N.H. and Gnanajothy, P. 1992. Comparative study of the enzymatic, hemorrhagic, procoagulant and anticoagulant activities of some animal venoms. Comp. Biochem. Physiol. 103C, 299-302.
  116. Tan, N.H. and Gnanajothy, P. 1992. The biological properties of venoms of some American coral snakes (Genus Micrurus). Comp. Biochem. Physiol. 101B, 471-74.
  117. Tan, N.H., Armugam, A. and Mirtschin, P.J. 1992. The biological properties of venoms from juvenile and adult taipan (Oxyuranus scutellatus) snake. Comp. Biochem. Physiol. 103B, 585-588.
  118. Tan, N.H., Yeo, K.H. and Nik Jaafar, M.I. The use of enzyme-linked immunosorbent assay for the quantitation of Calloselama rhodostoma (Malayan pit viper) venom and venom antibodies. Toxicon 30, 1609-1620.
  119. Tan, N.H. The Biochemistry of venoms of some venomous snakes of Malaysia A review. Tropical Biomedicine, 8, 91-103.
  120. Tan, N.H. and Gnanajothy, P. 1991. A comparative study of the biological activities of rattlesnake (genus Crotalus and Sistrurus) venoms. Comp. Biochem. Physiol. 98C, 455-461.
  121. Tan, N.H. and Gnanajothy, P. 1991. A comparative study of the biological properties of some sea snake venoms. Comp. Biochem. Physiol. 99B, 351-54.
  122. Tan, N.H. and Gnanajothy, P. 1991. A comparative study of the biological properties of venoms of snakes of the genus Bothrops (American lance-headed viper). Comp. Biochem. Physiol. 100B, 361-65.
  123. Tan, N.H. and Saifuddin, M.N. 1991. Substrate specificity of king cobra (Ophiophagus hannah) venom L-amino acid oxidase. Intn. J. Biochem. 23, 323-332.
  124. Tan, N.H. and Somasundaram, S. 1991. Purification and properties of L-amino acid oxidase from monocellate cobra (Naja naja kaouthia) venom. Int. J. Biochem. 24, 967-73.
  125. Tan, N.H., Arunmozhiarasi, A. and Gnanajothy, P. 1991. A comparative study of the biological activities of Dendroaspis (mamba) venoms. Comp. Biochem. Physiol. 99C, 463-66.
  126. Tan, N.H., Arunmozhiarasi, A. and Gnanajothy, P. 1991. A comparative study of the biological activities of Dendroaspis (mamba) venoms. Comp. Biochem. Physiol. 99C, 463-66.
  127. Tan, N.H. and Arunmozhiarasi, A. 1990.: In vivo interaction between neurotoxin, cardiotoxin and phospholipase A enzymes isolated from Malayan cobra (Naja naja sputatrix) venom. Toxicon 28, 1193-1198.
  128. Tan, N.H. and Gnanajothy, P. 1990. A comparative study of the biological activities of venoms from snakes of the genus Agkistrodon (Moccasins and Copper-heads). Comp. Biochem. Physiol. 95B, 577-582.
  129. Tan, N.H. and Gnanajothy, P. 1990. A comparative study of the biological activities of venoms from snakes of the genus Vipera. Comp. Biochem. Physiol. 96B, 683-688.
  130. Tan, N.H. and Gnanajothy, P. 1990. A comparative study of the biological properties of Australian elapid venoms. Comp. Biochem. Physiol. 97C, 99-106
  131. Tan, N.H. and Gnanjothy, P. 1990. A comparative study of the biological properties of krait (Genus Bungarus) venoms. Comp. Biochem. Physiol. 95C, 105-109.
  132. Tan, N.H. and Saifuddin, M.N. 1990. A comparative study of the edema inducing activity of snake venoms. Comp. Biochem. Physiol. 97C, 293-296.
  133. Tan, N.H. and Saifuddin, M.N. 1990. Isolation and characterization of a hemorrhagin from the venom of Ophiophagus hannah (king cobra). Toxicon 28, 385-392.
  134. Tan, N.H. and Saifuddin, M.N. 1990.: Purification and characterization of two acidic phospholipase A enzymes from king cobra (Ophiophagus hannah) snake venom. International Journal of Biochemistry, 22, 481-486.
  135. Tan, N.H., Saifuddin, M.N. and Nik Jaffar, M.I. 1990. Preparation of antibodies to king cobra (Ophiophagus hannah) venom hemorrhagin and investigation of their cross-reactivity. Toxicon 28, 1355-1359.
  136. Tan, N.H. and Saifuddin, Hj M.N. 1989. Enzymatic and toxic properties of Ophiophagus hannah (King cobra) venom and venom fractions. Toxicon, 27, 689-695.
  137. Tan, N.H. and Tan, C.S. 1989. Fractionation of Trimeresurus sumatranus sumatranus venom by DEAE-Sephacel ion exchange chromatography and investigation of the biological properties of the fractions. Toxicon, 27, 697-702.
  138. Tan, N.H. and Tan, C.S. 1989. The enzymatic activities and lethal toxins of Trimeresurus wagleri (Spekled pit viper) venom. Toxicon, 27, 349-357.
  139. Tan, N.H., Arunmozhiarasi, A. and Tan, C.S. 1989. A comparative study of the enzymatic and toxic properties of venoms of the Asian lance-headed pit viper (Genus Trimeresurus). Comp. Biochem. Physiol. 93B, 757-762.
  140. Tan, N.H., Poh, C.H. and Tan, C.S. 1989. The lethal and biochemical properties of Bungarus candidus (Malayan krait) venom and venom fractions. Toxicon 27, 1065-1070.
  141. Tan, N.H., Tan, C.S. and Khor, H.T. 1989. Isolation and characterization of the major phospholipase A from the venom of Trimeresurus purpureomaculatus (shore pit viper). Int. J. Biochem. 21, 1421-1425.
  142. Tan, N.H. and Tan, C.S. 1988. A comparative study of cobra (Naja) venom enzymes. Comparative Biochemistry and Physiology, 90B, 745-750.
  143. Tan, N.H. and Tan, C.S. 1988. Biological properties of Trimeresurus purpureomaculatus venom and its fractions. Toxicon 26, 989-996.
  144. Tan, N.H. and Tan, C.S. 1988. Partial purification of acetylcholinesterase from the venom of shore pit viper (Trimeresurus purpureomaculatus). Toxicon, 26, 505-508.
  145. Tan, N.H. and Tan, C.S. 1988.Acidimetric assay for phospholipase A using egg yolk suspension substrate. Analytical Biochemistry 170, 282-288.
  146. Tan, N.H., Arunmozhiarasi, A. and Tan, C.S. 1988. Comparative enzymology of Asian cobra venoms. Toxicon, 26, 42-43.
  147. Tan, N.H. and Tan, C.S. 1987. Enzymatic activities of Malayan cobra venom. Toxicon, 25, 1249-1253
  148. Chua, C.L., Tan, N.H. and Khor, H.T. 1986. Enzyme catalyzed hydrolysis of palm oil. J. Am. Oil Chem. Soc., 63, 538-540.
  149. Tan, N.H., Kanthimathi, M.S. and Tan, C.S. 1986. Enzymatic activities of Calloselasma rhodostoma venom. Toxicon, 24, 626-630
  150. Tan, N.H., Wong, K.C. and de Lumen B.O. 1984. Relationships of tannin levels and trypsin inhibitor activity with the in vitro protein digestibilities of winged beans. Journal of Agric. And Food Chemistry 32, 819-823.
  151. Tan, N.H., Zubaidah, A.R., Khor, H.T. and Wong, K.C. 1984.Chymotrypsin inhibitor activity in winged bean. Journal of Agric. And Food Chemistry, 32, 163-166.
  152. Tan, N.H. 1983. Gel filtration fractionation of winged bean proteins. Journal of the Science of Food and Agriculture, 34, 203-208
  153. Tan, N.H. 1983. Improvement of Malayan cobra antivenom. Toxicon, 21, 75-79.
  154. Tan, N.H. 1983. Isolation and characterization of two toxins from the venom of the Malayan cobra (Naja naja sputatrix). Toxicon, 21, 201-207.
  155. Tan, N.H., Zubaidah, A.R., Khor, H.T. and Wong, K.C. 1983. Winged bean tannin levels, phytate contents and hemagglutinating activity. Journal of Agric. And Food Chem., 31, 916-917.
  156. Khor, H.T., Tan, N.H. and Wong, K.C. 1982. The protein, trypsin inhibitor and lipid of the winged bean (Psophocarpus tetragonolobus) seeds. Journal of Science of Food and Agriculture, 33, 996-1000.
  157. Tan, N.H. 1982. Acidic phospholipase A2 from the venom of common sea snake (Enhydrina schistosa). Biochimica et Biophysica Acta, 717, 503-508.
  158. Tan, N.H. 1982. Cardiotoxins from the venom of Malayan cobra. Archives of Biochemistry and Biophysics, 218, 51-58.
  159. Tan, N.H. 1982. Isolation and preliminary characterization of two toxic phospholipase A2 from the venom of Malayan cobra. Biocheimica et Biophysica Acta 719, 599-605.
  160. Tan, N.H. and Wong, K.C. 1982. Thermal stability of trypsin inhibitor activity in winged bean. Journal of Agricultural and Food Chemistry, 30, 1140-1143.
  161. Tan, N.H., Lowe, E.S.H. and Iskandar, M. 1982. The extractability of winged bean trypsin inhibitors. Journal of The Science of Food and Agriculture, 33, 1327-1330.
  162. Chan, R.L., Tan, N.H. and Kaiser, E.T. 1978. Synthesis and characterization of a metal-binding peptide fragment of human carbonic anhydrase B. Bioorganic Chemistry, 7, 313-332.
  163. Tan, N.H. and Kaiser, E.T. 1977. Synthesis and characterization of a pancreatic trypsin inhibitor homologue and a model inhibitor. Biochemistry, 16, 1531-1541.
Chapter in Books
  1. Tan, C.H., Tan, K.Y., Tan, N.H. (2019). A Protein Decomplexation Strategy in Snake Venom Proteomics: Methods and Protocols. In: Functional Proteomics (Edited by X. Wang and M. Kuruc) DOI: 10.1007/978-1-4939-8814-3_5. Pp83-92. Springer Nature, Switzerland
  2. Tan, N.H. and Tan, C.H. (2017). Cytotoxicity of Snake Venoms and Toxins; Mechanisms and Applications. in: Snake Venoms and Envenomation: Modern Trends and Future Prospects (Yuri N. Utkin, Ed.). pp215-254. Nova Scientific Publications: Hauppauge, New York, USA.
  3. Tan, C.H and Tan, N.H. (2016). Toxinology of Snake Venoms: The Malaysian Context. Snake Venoms. pp1-37. (Edited by P. Gopalakrishnakone, H. Inagaki, A.K. Mukherjee, T. R. Rahmy and C. Vogel). Springer Science: Switzerland. Singapore.
  4. Shin Yee Fung and Nget Hong Tan (2015) Chapter 11: Fungal as a source of antitumor agent. In: Fungal Biomolecules: Sources, Applications and Recent Developments. (Eds. Drs. V.K. Gupta, R. Mach and S. Sreenivasaprasad), Wiley-Blackwell, USA. Pp 145-152.
  5. Tan, N.H., Fry, B.G., Jacson, T.N.W. and Fung, S.Y. (2014). Snake Venom L-Amino Acid Oxidase: Enzymology, Toxinology and Therapeutic Potentials. In: Fry B.G. ed. Clinical Effects and Biodiscovery Uses of Reptile Venoms, 2014, Oxford University Press
  6. Tan, N.H., Fung, S.Y., Sim, S.M. (2011) Anti-snake Venom Properties of Cowhage (Mucuna Pruriens) Seeds. In: Nuts and Seeds in Health and Disease. Preedy VR, Watson, R.R. and Patel VB Eds. Chapter 48, 395-400, Elsevier, USA.
  7. Tan, N.H. and Fung, S.Y. 2009. Snake venom L-amino acid oxidase. In: CRC Handbook of Venoms and Toxins of Reptiles. (Mackessy, S. Ed.), pp 219-234; Taylor and Francis/CRC Press.
  8. Tan, N.H. (1998): Kistomin (Calloselasma rhodostoma). In: Handbook of Proteolytic Enzymes (Barratt, A., Rawlings, N.D. and Woessner, J.F. Eds.) pp1287-1290. Academic Press, London.
  9. Tan, N.H. 1998. L-Amino Acid Oxidases and Lactate Dehydrogenases. In: Enzymes From Snake Venom, (Bailey, G.S. Ed.), Chapter 19, pp.579-598. Alaken Inc, Fort Collins, U.S.A.

RESEARCH INTEREST

  • Medical Education; Curriculum development
  • Biomedical studies on venom toxins
  • Bioactive substances from tiger milk mushroom (Tiger milk mushroom bioactive substances)

RESEARCH PROJECT

National
  1. 2016 - 2017, Private Funding
    A New Functional FIP from tiger milk mushroom ( Consultant)
  2. 2015 - 2017, Geran Penyelidikan Universiti Malaya (UMRG)
    Comparative functional proteomics of the venom of Wagler's pit viper ( Consultant)
  3. 2015 - 2017, Geran Penyelidikan Universiti Malaya (UMRG)
    Venoms of Southeast Asia pit viper ( Consultant)
  4. 2011 - 2016, MOHE-UM HIR
    Molecular Investigation of Disease mechanisms / Bioactive substances from nature ( Principal Investigator(PI))
  5. 2012 - 2014, Geran Penyelidikan Universiti Malaya (UMRG)
    Pharmacokinetic of bioactive substance from medically important Asiatic viperid venoms ( Consultant)
  6. 2011 - 2013, High Impact Research (HIR)
    Investigation of antivenom therapy of snakebites in South Asia and Southeast Asia and Antivenomics ( Principal Investigator(PI))
  7. 2012 - 2013, Geran Penyelidikan Universiti Malaya (UMRG)
    Investigation of the cytoxic action of a bio active protein from Malaysian king cobra veno ( Principal Investigator(PI))
  8. 2009 - 2012, Geran Penyelidikan Universiti Malaya (UMRG)
    Preclinical Trials of The New Polyvalent Antivenoms Against Southeast Asian Snake Venoms ( Principal Investigator(PI))
  9. 2009 - 2012, Geran Penyelidikan Universiti Malaya (UMRG)
    Pharmacological characterisation of the protective activity of Mucuna pruriens seed against the cardiovascular and neuromuscular depressant effects of snake venoms ( Consultant)
  10. 2010 - 2011, Postgraduate Research Grant(PPP)
    Preclinical trial of new polyvalent snake antivenoms ( Postgraduate Supervisor)
  11. 2010 - 2011, Postgraduate Research Grant(PPP)
    Biomedical characterisation of the venom of hump- nosed pit viper (Hypnale hypnale) ( Postgraduate supervisor)
  12. 2008 - 2009, Short Term Research Fund (Vote F)(PJP)
    King Cobra Venom L-Amino Acid Oxidase as a Therapeutic Molecule ( Principal Investigator(PI))
  13. 2006 - 2008, ScienceFund
    Biomedical and pharmacological studies on Mucuna pruriens seed components and snake venom toxins ( Principal Investigator(PI))
  14. 2002 - 2006, ScienceFund
    Pharmacological and Biomedical studies of Malaysian snake venom toxins ( Principal Investigator(PI))
  15. 1995 - 2000, ScienceFund
    Biomedical studies and genetic engineering of snake venom toxins ( Principal Investigator(PI))
International
  1. 2009 - 2011, ScienceFund
    Evaluation of Mucuna pruriens seed proteins as anti-snake venoms and cardioprotective agents ( Principal Investigator(PI))
University
  1. 2007 - 2008, Short Term Research Fund (Vote F)(PJP)
    Biomedical studies on glycoproteins from Velvet beans (Mucuna pruriens) ( Principal Investigator(PI))

CONSULTANCY PROJECT

  • Panel Frgs UM, University of Malaya
    01 Dec 2015 - 01 Dec 2018 (National)
  • Reviews Advisor, WHO
    01 Dec 2017 - 01 Dec 2018 (International)
  • Panel Penilai Agengsi Kelayakan Malaysia (Mqa), Universiti dan Kolej
    01 Dec 2011 - 01 Dec 2018 (National)
  • Review Advisor, Who Snakebite Envenoming Working Group (Sbe-Wg), WHO
    01 Jan 2017 - 01 Jan 2018 (International)
  • Reviewer of Manuscript from Toxicon, Toxicon
    01 Dec 2013 - 01 Dec 2017 (International)
  • Ahli Panel Penilai Agensi Kelayakan Malaysia dan Ahli Panel Dalaman Universiti Malaya, Universiti Malaya
    01 Apr 2011 - 01 Apr 2014 (National)
  • Reviewer of Manuscript from Vaccines, Vaccines
    01 Jan 2013 - 01 Jan 2013 (International)

PAPER PRESENTED

PLENARY SPEAKER
  1. Snake venoms: Pharmacology and Toxinology, ANSEM 3, Malaysian Society on Toxinology (International) (02 Sep 2014 - 04 Sep 2014)
  2. Snake venom composition and effects: a Malaysian context, ANSEM 2012 (National Workshop on Advanced Management of Marine Animals & Snake Envenomation in Malaysia), 1st National Workshop AMSEM 2012, UKM (National) (29 Mar 2012 - 30 Mar 2012)
INVITED SPEAKER
  1. Biochemistry of Malayan pit viper venom, The Third Asia Pacific Congress on Thrombosis and Hemostasis (14 Oct 2004 - 16 Oct 2004)
ORAL PRESENTER
  1. Breathing New Life to a Malaysia Lost National Treasure - The Tiger-Milk Mushroom (Lignosus rhinocerus), International Society of Mushroom Congress XVIII, International Society of Mushroom Science (International) (26 Aug 2012 - 30 Aug 2012)
  2. Purification and characterization of a yeast killer protein with anti-Candida and glucanase activity, 22nd FAOBMB Confeence , FAOBMB (National) (05 Oct 2011 - 07 Oct 2011)
  3. Immune response elicited by immunization of rabbits with Hypnale hypnale venom and the ELISA cross-reactivities of the antibodies, 4th International Conference on Natural Toxins, Egyptian Society on Toxinology (International) (20 Dec 2010 - 22 Dec 2010)
  4. The toxinological properties of Merrem's humped-nose pit viper (Hypnale hypnale) and its neutralization by commercial antiveno, First National COnference on Animal, Microbial, Plant Toxins and Snaktebite Management, Indian Institute of Chemical Biology (International) (11 Dec 2010 - 12 Dec 2010)
  5. Neutralization of lethalities of some snake venoms by antibodies raised against Mucuna pruriens seed extract, Inaugural Conference on Global Issues in Clinical Toxinology (23 Nov 2008 - 28 Nov 2008)
POSTER PRESENTER
  1. Geographical variations of Naja kaouthia (monocle cobra) venom from Southeast Asia: a venomic and functional study. , 18th World Congress of International Society on Toxinology, International Society on Toxinology (International) (25 Sep 2015 - 30 Sep 2015)
  2. An Indian polyvalent antivenom protects against the Naja kaouthia (monocellate cobra) venom-induced neuromuscular blockade and reverses the cardio-depresant effect in isolated tissue preparations, Golden Helix Symposium (International) (12 Mar 2015 - 13 Mar 2015)
  3. Cross neutralization of some Southeast Asian cobra and krait venoms by Indian polyvalent antivenoms, 17th Congress of the European Section of the International Society of Toxinology, International Society on Toxinology (International) (11 Sep 2011 - 15 Sep 2011)
  4. Cytotoxicity and antibacterial effects of L-amino acid oxidase from king cobra venom, 4th International Conference on Natural Toxins., Egyptian Society on Toxinology (International) (20 Dec 2010 - 22 Dec 2010)
  5. Serum kinetics of Naja sputatrix (spitting cobra) venom in rabbit and immunological responses in rabbit immunized with Naja sputatrix venom and venom components, 35th Annual Conference of the Malaysian Society of Biochemistry and Molecular Biology, Malaysian Society of Biochemistry and Molecular Biology (National) (27 Jul 2010 - 28 Jul 2010)
  6. Biochemical and toxinological characterization of H.hypnale pit viper venom and its neutralization by a commercial antivenom, 35th Annual Conference of the Malaysian Society of Biochemistry and Molecular Biology, Malaysian Society of Biochemistry and Molecular Biology (National) (27 Jul 2010 - 28 Jul 2010)
  7. Investigation on 28-day subacute toxicity of cultivated tiger's milk mushroom (Lignosus rhinocerus), 35th Annual Conference of Malaysian Society of Biochemistry and Molecular Biology, Malaysian Society of Biochemistry and Molecular Biology (National) (27 Jul 2010 - 28 Jul 2010)
  8. Investigation on the anticancer properties and subacute toxicity of cultivated tiger milk mushroom. FEBS Journal 277, p62, 35th FEBS Congress, Sweden Biochemical Society (International) (26 Jun 2010 - 01 Jul 2010)
  9. Cytotoxicity of king cobra (Ophiophagus hannah) venom L-amino acid oxidase. FEBS Journal 277, p60, 35th FEBS Congress, Sweden Biochemical Society (International) (26 Jun 2010 - 01 Jul 2010)
  10. Neutralizing potencities of two snake antivenoms against the lethality and pharmacological activities of different Malaysian snake venoms, Malaysian Society of Pharmacology and Physiology Scientific Meeting, Malaysian Society of Pharmacology and Physiology (National) (02 Jun 2010 - 03 Jun 2010)
  11. Enzymatic and pharmacological activities of Merrem's humped-nose pit viper venom and its neutralization by a commercial antivenom, Malaysian Society of Pharmacology and Physiology Scientific Meeting., Malaysian Society of Pharmacology and Physiology (National) (02 Jun 2010 - 03 Jun 2010)
  12. Biomedical and pharmacological studies on Mucuna pruriens seed components and snake venom toxins, National Biotechnology Seminar, National Biotechnology Center (National) (24 May 2010 - 26 May 2010)
  13. A Malaysian traditional medicine for cancer treatment: Cendawan susu harimau, UK-Malaysia Symposium on Drug Discovery and Development for Cancer, Cancer Research Initiatives Foundation (International) (24 Feb 2010 - 25 Feb 2010)
  14. Cytotoxicity and antibacterial effects of an L-amino acid oxidase isolated from Ophiophagus hannah (king cobra) snake venom, 34th Annual Conference of the Malaysian Society of Biochemistry and Molecular Biology, Malaysian Society of Biochemistry and Molecular Biology (National) (07 Oct 2009 - 08 Oct 2009)
  15. Pathway analysis of differently expressed genes in the heart of rat injected with lethal dose of Naja sputatrix (Malayan cobra) snake venom, 18th Scientific Meeting of the Malaysian Society for Molecular Biology and Biotechnology,, Malaysian Society for Molecular Biology and Biotechnology (National) (18 Aug 2009 - 20 Aug 2009)
  16. The protective effect of Mucuna pruriens seed against cobra venom poisoning: immunological studies, 33rd Federation of European Biochemical Societies Congress and 11th IUB Congress, Federation of European Biochemical Societies (29 Jun 2008 - 04 Jul 2008)
  17. The protective effect of Mucuna pruriens seed against cobra venom poisoning: gene expression studies, 32nd Federation of European Biochemical Societies Congress (02 Jul 2007 - 07 Jul 2007)
  18. Studies on the Epitopes of Malayan Pit Viper Venom Hemorrhagin, 30th Federation of European Biochemical Societies Congress and 10th IUB Congress (02 Jul 2005 - 07 Jul 2005)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2015) Reviewer for the following journals: BMC Complementary medicine, Chemico Biological Interaction, J ethnopharmacology, (Reviewer)
  2. (2014) Reviewer for the journals BBA General subjects, FEBS Journal, (Reviewer)
  3. (2010) Reviewer of paper submitted to JUMMC 2010 , (Reviewer)
  4. (2010) Reviewer of Journal of Medicinal Plant Research 2010 , (Reviewer)
  5. (2010) External examiner for Master candidate USM (Yeoh Lay Chin) , (External Examiner)
  6. Internal examiner of MSc thesis (UM) of Adyani Azizah Abd Halim , (Internal Examiner)
  7. External examiner for Shanmugasundram Deivanayagam MSc, National University of Singapore 2003 , (External Examiner)
  8. External examiner of Siew Phui Yee MSc Thesis National University of Singapore 2004 , (External Examiner)
  9. External Examiner of Cher Dyi Ni PhD Thesis National University of Singapore 2005 , (External Examiner)
  10. Reviewer of Journal of Natural Toxins, 1996, 1997 , (Reviewer)
  11. Reviewer, Comparative Biochemistry and Physiology 1996-- , (Reviewer)
  12. Guest Editor, Toxin Reviews 1996 , (Editor)
  13. Evaluation of ScienceFund research project as Panel member of MOSTI , (Panel member)
  14. Evaluation of Bachelor of Biochem (Hon) course of Universiti Tunku Abdul Rahaman and Bachelor of Biotechnology (Hon)of INTI University as a panel member of MQA , (Panel member)
Contribution to external organisation
  1. (2010) Research Collaboration, University of Colombo, Sri Lanka (Dr Christeine Ariaratnam), International
  2. (2009) Research Collaboration, Queen Savaobha Memorial Institute, Thai Red Cross Society, Thailand, International
  3. (2008) Research Collaboration, University of Jos, Jos, Nigeria, International

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2017) Toxinological study of the venom of Sri Lankan common krait, Angeline Oh Mei Feng
  2. (2016) A Multifaceted Approach for Deeper Insights Into Pathophysiology of Sea Snake Venoms: Towards the Optimization of the Management of Sea Snake Envenomation In Malaysia., Tan Choo Hock
  3. (2014) Venomics and transcriptomics of viperid venoms, Tang Lai Har
  4. (2014) Biomedical studies of Lignosus tigris, Kong Boon Hong
  5. (2013) Venomics of elapid venoms, Tan Kae Yi
  6. (2011) Proteomics and Genomics of Tiger Milk Mushroom, Yennie Yap Hui Yeng
  7. (2010) Evluation of potency of new polyvalent antivenom, Leong Poh Kuan
  8. (2010) Biomedical studies of Tiger Milk Mushroom, Lee Sook Shien
  9. (2009) King cobra venom L amino acid oxidase as therapeutic agent, Lee Mui Li
  10. (2009) Biopharmacology of Venom Toxins, Michelle Yap Khai Khun
  11. (2009) Biopharmacology of Hypnale hypnale venom, Tan Choo Hock
  12. (2008) Biomedical studies on the protection of Mucuna pruriens seed extract against the toxic actions of snake venoms, Cik Fung Shin Yee
  13. (1996) Biochemical and molecular cloning studies on the phospholipase enzymes and neurotoxins in the venom of Naja naja sputatrix, Arunmozhiarasi Armugam
  14. (1995) Biochemical and immunological studies on Malayan pit viper venom hemorrhagin, Ponnudurai Gnanajothy
Master
  1. (2008) Mucuna pruriens and Snake venom toxins, Tan Piow Teck
  2. (2008) Animal Toxins, Saremi Kamelia
  3. (2003) Phospholipases A from Bungarus candidus venom, Chong Yin Jiun
  4. (2001) Biochemical and immunological characterization of the major hemorrhagin from T.purpureomaculatus venom, Fung Shin Yee
  5. (1998) Thrombin-like enzymes of Trimeresurus albolabris and Trimeresurus purpureomaculatus venoms, Lu Gen Jyn
  6. (1992) The use of enzyme-linked immunosorbent assay in the quantitation and studies of the antigenic properties of king cobra venom, Lim Kian Khim
  7. (1991) The use of enzyme-linked immunosorbent assay in the quantitation and antigenic studies of some Malaysian pit viper venoms, Yeo Kei Huat
  8. (1991) A comparative study of the biological properties of snake venoms, Gnanajothy Ponnudurai
  9. (1990) Biochemical studies on king cobra venom, Safuddin MN
  10. (1989) Studies on the phospholipases A and anticoagulant activity of Malayan cobra venom, Arunmozhiarasi Armugam
  11. (1988) Isolation and characterization of phospholipase A from Trimeresurus purpureomaculatus, Tan Chon Seng
  12. (1988) Investigation of technetium-labelled hematoporphyrin derivative for nuclear imaging of malignancies, Meh Jabeen Zainuddin

TEACHING

Bachelor
  1. (2017) DD101 - Biochemistry for Dentistry
  2. (2017) UMMP - Biochemistry (Medical Stage 1 and 2)
  3. (2014) MWEF1152 - Pharmaceutical Biochemistry

PATENT/IPR

  • Lignosus rhinocerotis serine protease
    Patent (National)
  • Serine protease and lectin with anti-proliferative activity from L. tigris scleortium
    Patent (National)
  • Lignosus Rhinocerus (Tiger-Milk mushroom) As Anti-Inflammatory Agent
    Patent (National)
  • Mushroom extract for use in the treatment of cancer
    Patent

SOCIAL RESPONSIBILITY ACTIVITIES

  • Panel Mtsf Grant Research Symposium, (22 Nov 2012)
  • Panel Committee Umrg Htm Cluster 2012, (01 Jan 2012)
  • Panel Member Sciencefund, Mosti, (01 Jan 2005)