Curriculum Vitae

ASSOCIATE PROF. DR. KHONG TAK LOON

Associate Professor
  • Department of Surgery
    Faculty of Medicine

AREAS OF EXPERTISE

ACADEMIC QUALIFICATION

  • FRCS, (General Surgery)
    Royal College of Surgeons, England
  • MD, (Medicine and Surgery)
    Imperial College London, Uk
  • MSC (SURGICAL SCIENCE), (Science)
    University of London, Uk
  • MBBS, (Medicine and Surgery)
    Edinburgh University, United Kingdom

ADMINISTRATIVE DUTIES

  • Committee member for Tabung Prof Atiya
    10 May 2021 - 10 May 2023 (Faculty)
  • Task Force Member
    01 Jan 2022 - 31 Dec 2022 (University Malaya)
  • Chairman
    04 Feb 2021 - 04 Feb 2021 (Faculty)
  • Member of the UMMC Drug Safety Committee
    08 Sep 2017 - 31 Dec 2020 (University Malaya)
  • Head of Unit
    15 Jan 2019 - 31 Jul 2020 (Faculty)
  • Coordinator for Surgical End of Posting Exams and Coordinator for the UMMP 3.2 Barrier exams
    04 Dec 2017 - 31 Jul 2020 (University Malaya)
  • Affiliate member to the UM Clinical Research Institute
    04 Oct 2017 - 31 Dec 2019 (University Malaya)
  • Stage 2 Surgical Block Chair for Gastroenterology and Nutrition
    01 Apr 2018 - 01 Feb 2019 (University Malaya)

AWARD AND STEWARDSHIP

  • Alexander Simpson-Smith Prize
    Alexander Simpson-Smith Foundation, 2006 (National)
  • Alan Edwards Prize
    British Association of Surgical Oncology , 2006 (International)

PUBLICATIONS

Article in Journal
WoS
  1. Cheng, K. J., Mohammed, E. H. M., Khong, T. L., Zain, S. M., Thavagnanam, S., & Ibrahim, Z. A. (2021). IL-1 alpha and colorectal cancer pathogenesis: Enthralling candidate for anti-cancer therapy. Critical Reviews in Oncology Hematology, 163, 13. doi: 10.1016/j.critrevonc.2021.103398
Others
  1. M. A. Shafhawi Adznan, & Khong Tak Loon. (2021). A Case Series of Complex Pelvic Abscesses: Importance of Early Recognition and Institution of Individualised Treatment. Borneo Journal of Medical Sciences (BJMS), 16(3), 63
  2. M. A. Shafhawi Adznan, & Khong Tak Loon. (2021). A Case Series of Complex Pelvic Abscesses: Importance of Early Recognition and Institution of Individualised Treatment. Borneo Journal of Medical Sciences (BJMS), 16(3), 63
  3. Cheng, KJ. (2021). IL-1 and colorectal cancer pathogenesis: Enthralling candidate for anti-cancer therapy. Crit Rev Oncol Hemat
  4. Khong, T. L., Khoo, X. H., & Hilmi, I. (2021). A Systematic Review on the Effectiveness of Clinician-Directed Interventions to Improve Compliance to Post-Polypectomy Surveillance Guidelines. Digestive diseases. https://doi.org/10.1159/000520859
  5. Khong TL, Naik K, Sivakumar R, Shah S (2015). Impact of the United Kingdom national bowel cancer awareness campaigns 2012 on colorectal cancer services and patient survival. Colorectal Dis. 2015 Dec;17(12):1055-61
  6. Ferguson HJ1, Hall NJ2, Bhangu A1; National Surgical Research Collaborative (2014). A multicentre cohort study assessing day of week effect and outcome from emergency appendicectomy. BMJ Qual Saf, 23(9):732-40
  7. Khong, T. (2014). Outcome of appendicectomy in children performed in paediatric surgery units compared with general surgery units. British Journal of Surgery Volume, 101(6), 707-714
  8. National Research Collaborative (2013) . Multicentre observational study of performance variation in provision and outcome of emergency appendicectomy. Br J Surg, 100(9):1240-52.
  9. Tak L Khong, Ngayu Thairu, Helene Larsen, Peter M Dawson, Serafim Kiriakidis and Ewa M Paleolog (2013). Identification of the angiogenic gene signature induced by EGF and hypoxia in colorectal cancer. BMC Cancer, 13:518
  10. Helene Larsen, Barbara Muz, Tak L. Khong, Marc Feldmann and Ewa M. Paleolog. (2012). Differential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in rheumatoid arthritis. Arthritis Res Ther. 14(4), R180.
  11. Khong TL, Siddiqui J, Mallinson P, Horton D, Gandhi J, Daniel R. (2012). Herlyn-Werner-Wunderlich syndrome: uterus didelphys, obstructed hemivagina, and ipsilateral renal agenesis-role of sonographically guided minimally invasive vaginal surgery. Eur J Pediatr Surg, 22(2), 171-3
  12. Khong TL, Larsen H, Raatz Y, Paleolog E. (2007). Angiogenesis as a therapeutic target in arthritis: learning the lessons of the colorectal cancer experience. Angiogenesis, 10(4):243-58.
  13. Khong TL, Winstanley V, Lee G, Christmas T, Ramsay J. (2006) Primary uretero-iliac fistula: the unusual source of haematuria. Int Urol Nephrol. 39(3):751-3.

RESEARCH PROJECT

National
  1. 2020 - 2024, Fundamental Research Grant Scheme (FRGS)
    The Role Of Rip1/il-1a/il-8 Pathway In Mediating Epithelial-mesenchymal Transition (emt), Cellular Invasion In Colorectal Cancer ( Co-Researcher)
  2. 2022 - 2024, University Grant
    Role of Prophylactic PICO Dressing in Reducing SSI among Adult Patients Undergoing Emergency Laparotomy in University Malaya Medical Centre (UMMC) ( Co-Researcher)
  3. 2019 - 2023, Skim Geran Penyelidikan Trans-Displin (TRGS)
    Elucidating The Interaction Between Blastocystis Sp. And Microbial Diversity To Study Its Effect On Healthy Individuals And Patients With Different Stages Of Colorectal Cancer ( Co-Researcher)
  4. 2020 - 2023, Fundamental Research Grant Scheme (FRGS)
    The Role of RIP1/IL-1a/IL-8 Pathway in Mediating Epithelial-mesenchymal Transition (EMT), Cellular Invasion in Colorectal Cancer ( Consultant)
  5. 2021 - 2022, Private Funding - Manage by UMCARES
    Cancer Multisectoral Collaboration Network In Implementing A Pilot Cancer Early Dectection Community Project To Reduce Breast And Other Cancers Early Diagnosis Barriers In The Urban B40 Group In Taman Medan Pj ( Co-Researcher)
  6. 2020 - 2022, Geran Penyelidikan Universiti Malaya (UMRG)
    Effectiveness of a Clinical Decision Support System to improve compliance to post polypectomy surveillance guidelines ( Principal Investigator(PI))
  7. 2020 - 2022, Private Funding
    Association between RIP1, NLRP3, HMGB1 and IL-1 in colorectal cancer tumour and serum samples ( Consultant)
  8. 2019 - 2021, Fundamental Research Grant Scheme (FRGS)
    Development of a predictive tool for the predisposition of colorectal cancer using gut microbiome analysis and mucosal immunity with reference to Blastocystis sp ( Consultant)
  9. 2019 - 2021, Private Funding
    ProPBM : A randomised control trial comparing a modified patient blood management (PBM) protocol with standard care for patients undergoing major surgery. ( Consultant)
International
  1. 2020 - 2023, International Funding
    Subproject 1: Clinical Characteristics And Risk Factors For Mdro Related Ssi Among Trauma Patients ( Co-Researcher)
  2. 2020 - 2023, International Funding
    Subproject 2 : Antimicrobial Susceptibility And Genotypic Characteristics Of Mdro Isolated From Surgical Site Infections ( Co-Researcher)
  3. 2021 - 2021, NONE
    EAGLE study - ESCP Safe-anastomosis Programme in Colorectal Surgery ( Principal Investigator(PI))
  4. 2018 - 2018, NONE
    GlobalSurg 3: Quality and Outcomes in Global Cancer Surgery ( Consultant)
University
  1. 2020 - 2023, Private Funding
    Association Between Rip1, Nlrp3, Hmgb1 And Il-1 In Colorectal Cancer Tumour And Serum Samples ( Co-Researcher)
  2. 2020 - 2023, Private Funding
    Effectiveness Of A Clinical Decision Support System To Improve Compliance To Post Polypectomy Surveillance Guidelines ( Principal Investigator(PI))

CONSULTANCY PROJECT

  • Ibd Digital Education Solution Project, Jenssen, Johnson and Johnson, Consultant
    15 Dec 2021 - 31 Dec 2022 (National)

PAPER PRESENTED

INVITED SEMINAR
  1. Challenges on Pre-Operative , Intra-Operative, Post-Operative care of elderly patients, Annual Scientific Congress of the College of Surgeons 2019., College of Surgeons, Academy of Medicine of Malaysia (International) (02 Aug 2019 - 04 Aug 2019)
INVITED SPEAKER
  1. Isolated ileocecal Crohn s disease: Is it time to swing the pendulum back to surgery, GUT 2022 - MSGH annual conference, Malaysian Society of Gastroenterology and Hepatology (International) (20 Aug 2022 - 20 Aug 2022)
  2. Management of anastomotic stricture, Singapore Colorectal Society Online Masterclass, Singapore Colorectal Society (International) (18 Aug 2022 - 18 Aug 2022)
  3. Long term complication of obstetric anal sphincter injury: identification and management of anal sphincter injury and rectovaginal fistula, OPTIMUM - Obstetric Perineal Trauma Identification and Management, O&G Dept (National) (24 Jun 2022 - 24 Jun 2022)
  4. Surgical dilemmas in older persons - perspectives on when to operate and when not to, Malaysian Hybrid Conference on Healthy Ageing, Malaysian Health Ageing Society (International) (15 Mar 2022 - 17 Mar 2022)
  5. Approaching recurrent rectal cancers It s a team effort, Coloproctology 2022, Malaysian Society of Colorectal Surgeons (International) (04 Mar 2022 - 06 Mar 2022)
  6. Transdisciplinary approach in perioperative medicine, Malaysian Society of Anaesthesiologists and College of Anaesthesiologists Annual Scientific Congress 2021 , Malaysian Society of Anaesthesiologists and College of Anaesthesiologists (International) (06 Aug 2021 - 08 Aug 2021)
  7. Adapting our colorectal services at a COVID-hybrid university hospital as we transition from Movement Control Order (MCO) to Recovery MCO (RMCO), Adjusting to the new norm in Colorectal Practice, Ethicon, Johnson and Johnson (International) (27 Jul 2020 - 27 Jul 2020)
  8. Laparoscopic Total Mesorectal Excision in Male Patients, Coloproctology - Annual Scientific Congress 2020, Malaysian Society of Colorectal Surgeons  (International) (05 Mar 2020 - 08 Mar 2020)
  9. Surgical considerations in elderly patients with cancer, Surgical consideration for the oncogeriartric patient, Department of Surgery, University Malaya (University) (05 Oct 2019 - 05 Oct 2019)
  10. Heated Intraperitoneal Chemotherapy and cytoreductive surgery in Gynae malignancies, Malaysian International Congress of O&G 2019, Obstetrical & Gynaecological Society of Malaysia  (International) (18 Jul 2019 - 21 Jul 2019)
  11. Colorectal cancer for the General Surgical Trainees, Coloproctology 2018, Malaysian Association of Colorectal Surgeons (National) (02 Mar 2018 - 04 Mar 2018)
ORAL PRESENTER
  1. Regulation of the proangiogenic switch on colorectal cancer cells by epidermal growth factor and hypoxia, BASO ACS & Cancer Genetics Group Joint Scientific Conference 2009, British Association of Surgical Oncology (International) (23 Jun 2009 - 24 Jun 2009)
  2. Investigation of convergence between Epidermal Growth Factor and hypoxia on the pro-angiogenic switch in colorectal cancer, Surgical Academic Research Society 2008, Surgical Academic Research Society (National) (10 Mar 2008 - 12 Mar 2008)
  3. Regulation of the proangiogenic switch in colorectal cancer cells by Epidermal Growth Factor and hypoxia, BASO The Association for Cancer Surgery Annual Scientific Conference 2006, British Association of Surgical Oncology (National) (15 May 2006 - 17 May 2006)
  4. Hypoxia: Its role in angiogenesis and Colorectal Cancer, Simpson-Smith Memorial Day 2006, Imperial College London (National) (08 May 2006 - 10 May 2006)
POSTER PRESENTER
  1. United Kingdom National Bowel Cancer awareness programme More pain, no gain?, British Society of Gastroenterology Annual Meeting 2014, British Society of Gastroenterology (International) (03 Jun 2014 - 06 Jun 2014)
  2. Investigation of convergence between EGF and hypoxia on the proangiogenic switch in colorectal cancer, Assoc of Coloproctology of Great Britain & Ireland Annual Meeting 2009, Association of Coloproctology of Great Britain & Ireland (International) (08 Jun 2009 - 10 Jun 2009)
  3. Regulation of the proangiogenic switch on colorectal cancer cells by epidermal growth factor and hypoxia, Assoc of Surgeons of Great Britain & Ireland Annual Meeting 2009, Association of Surgeons of Great Britain & Ireland (International) (13 May 2009 - 15 May 2009)
  4. Hypoxia is a potent regulator of the pro-angiogenic switch in colorectal cancer cells, Assoc of Coloproctology of Great Britain & Ireland Annual Meeting 2007, Association of Coloproctology of Great Britain & Ireland (International) (09 Jul 2007 - 11 Jul 2007)
  5. Investigation of convergence between Epidermal Growth Factor and hypoxia on the pro-angiogenic switch in colorectal cancer, Simpson-Smith Memorial Day 2007, Imperial College London (National) (07 May 2007 - 07 May 2007)

ACADEMIC/PROFESSIONAL SERVICES

Evaluation
  1. (2022) Evaluation of Md Thesis, University, (Internal Examiner)
  2. (2022) Reviewer for Article, International, (External Evaluator)
  3. (2022) Upgrade from Masters to Phd, University, (Internal Assessor)
  4. (2021) Sonographic Cervical Length and Its Impact On Timing of Delivery and Inducibility of Labout, University, (External Assessor)
  5. (2021) Malaysia Toray Science Foundation - Grant Assessor, University, (External Assessor)
  6. (2021) Assessing Awareness of Crc and Uptake of Faecal Occult Blood Tests, University, (Internal Evaluator)
Contribution to external organisation
  1. (2022) Development of a National Inflammatory Bowel Disease Preceptorship Programme, National, (Expert Advisor)
  2. (2022) Inflammatory Bowel Disease Preceptorship Programme, National, (Expert Advisor)
Contribution to event
  1. (2022) The Use of Intraoperative Radiotherapy in Rectal Cancer, International, (Panelist/Moderator)
  2. (2022) Assessment of Perianal Fistulas - Eua, Eaus or Mri?, National, (Course Facilitator)
Mentoring
  1. (2022) Training The Trainers Directors Project, National, (Co-curriculum Advisor)
  2. (2021) Produced Educational Content On Workplace Based Assessments for The Training The Trainers Workshop, National, (Mentor)

SUPERVISION

Postgraduate Student
Master
  1. (2021) -, KHAW CHERN YANG JASON
  2. (2021) -, ROSDI BIN PON
  3. (2020) -, LYNETTE SHEENA DEWA RAJO
  4. (2019) Effectiveness of an online educational module in improving compliance to post polypectomy colonoscopy surveillance, Jessy Ng Suk Ning
  5. (2019) -, ELEANOR FELSY PHILIP
  6. (2019) -, NG SUK NING
  7. (2018) -, YOHESUWARY A/P GUNARASA
  8. (2018) -, SEE BOON KEONG

TEACHING

Master
  1. (2022) MTA27200 - Basic Clinical Training
  2. (2022) MTA2782B - Final Examination (Clinical and Viva Voce)
  3. (2022) MTA2712B - Part I Examination (Clinical)
  4. (2021) MTA27200 - Advanced Clinical Training
  5. (2019) OTHER - Non Technical Skills for Surgeons
  6. (Nov 2018) OTHER - Non Technical Skills Course for Surgeons
  7. () OTHER - Science of Tissue Management
  8. () OTHER - Science of Tissue Management 2019
  9. () OTHERS - Laparoscopic Colorectal Surgery Hands-On Cadaveric Workshop
Bachelor
  1. (2022) MIA - Bachelor of Medicine, Bachelor of Surgery
  2. (2021) MIA4001 - Stage 1
  3. (2020) MIA2001 - Mbbs Stage 2
  4. (2020) MIA3001 - Ummp 3.1
  5. (2019) MIA4001 - Ummp 3.2
  6. (2018) MD01 - Bachelor of Dental Surgery
  7. (2018) MIA2001 - Ummp Stage 2
  8. (2018) MIA3001 - Ummp Stage 3.1
  9. (2018) MIA4001 - Ummp Stage 3.2
Others
  1. () OTHER - Basic Surgical Suturing and Knot Tying Course

SOCIAL RESPONSIBILITY ACTIVITIES

  • Speaker On Bowel Cancer Screening, (12 Oct 2022 - 12 Oct 2022) (National)
  • Webinar Entitled "Working Together in Stoma Care' in Commemoration of Norma Gill Day., (26 Jun 2021 - 26 Jun 2021) (International)
  • Expert Panel for The Antibiotics Awareness Week - Use of Antibiotics from The Perspective of a Surgeon, (10 Nov 2020 - 10 Nov 2020)
  • Rebung Project - Community Project to Improve Awareness of Cancer and to Facilitate Early Diagnosis and Referral from Primary Care to Hospitals, (21 Sep 2020 - 08 Apr 2021)
  • Community Awareness and Support for Cancer Survivors - Talk On 'Frailty and Outcomes in The Elderly Cancer Patients', (05 Oct 2019 - 05 Oct 2019)