Curriculum Vitae

DR. CHIN SEK PENG

Senior Lecturer
  • Department of Pharmaceutical Chemistry
    Faculty of Pharmacy
  • spchin
  • 03-79677831

AREAS OF EXPERTISE

  • DRUG DISCOVERY
    receptor-ligand interactions
  • OTHER BIOINFORMATICS
    Molecular dynamics simulation, Molecular docking, Homology modelling

ACADEMIC QUALIFICATION

  • PhD (Drug Discovery), (DRUG DISCOVERY)
    Universiti Malaya (UM)
  • MSc (Pharmacy), (FARMASI)
    Universiti Sains Malaysia (USM)
  • BSc (Hons)(BioInfo), (BIOINFORMATIK)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • Programme Coordinator
    16 Sep 2019 - 18 Jan 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Postgraduate Coordinator (Sem 1)
    16 Sep 2019 - 01 Jan 2022 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Ahli Jawatan Kuasa Kurikulum
    01 Oct 2019 - 01 Jan 2022 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Departmental Exam Coordinator
    25 Sep 2019 - 01 Jan 2022 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Assistance Quality Manager (Teaching & Learning)
    16 Sep 2019 - 01 Jan 2022 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)

AWARD AND STEWARDSHIP

  • Best Presenter (Young Researcher Category)
    Asia Consortium of Computational Materials Science - 9 (ACCMS-9), 2017 (International)

PUBLICATIONS

Article in Journal
WoS
  1. Manimaran, Malarmugila; Teo, Yin Yin; Kah, James Chen Yong; Beishenaliev, Adilet; Loke, Yean Leng; Foo, Yiing Yee; Ng, Shiow-Fern; Chee, Chin Fei; Chin, Sek Peng; Faruqu, Farid Nazer; Chang, Chia-Yu; Misran, Misni; Chung, Lip Yong; Leo, Bey Fen; Chiou, Shih-Hwa; Chang, Chia-Ching; Tay, Sun Tee; Kiew, Lik Voon (2024). PDADMAC/Alginate-Coated Gold Nanorod For Eradication of Staphylococcus Aureus Biofilms, INTERNATIONAL JOURNAL OF NANOMEDICINE. 19, 3697-3714. doi:10.2147/IJN.S452085
  2. Yap, Cheng Hong; Ramle, Abdul Qaiyum; Lim, See Khai; Rames, Avinash; Tay, Sun Tee; Chin, Sek Peng; Kiew, Lik Voon; Tiekink, Edward R. T.; Chee, Chin Fei (2023). Synthesis and Staphylococcus aureus biofilm inhibitory activity of indolenine-substituted pyrazole and pyrimido[1,2-b]indazole derivatives, BIOORGANIC & MEDICINAL CHEMISTRY. 95. doi:10.1016/j.bmc.2023.117485
  3. Chua, R. A. H. W.; Lim, S. K.; Chee, C. F.; Chin, S. P.; Kiew, L. V.; Sim, K. S.; Tay, S. T. (2022). Surgical site infection and development of antimicrobial sutures: a review, EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. 26(3), 828-845
  4. Tan, Ke Han; Chin, Sek Peng; Heh, Choon Han (2022). Automated in silico EGFR Peptide Inhibitor Elongation using Self-evolving Peptide Algorithm, CURRENT COMPUTER-AIDED DRUG DESIGN. 18(2), 150-158. doi:10.2174/1573409918666220516144300
  5. Chong, W. L., Chupradit, K., Chin, S. P., Khoo, M. M., Khor, S. M., Tayapiwatana, C., . . . Lee, V. S. (2021). Protein-Protein Interactions: Insight from Molecular Dynamics Simulations and Nanoparticle Tracking Analysis. Molecules, 26(18), 13. doi: 10.3390/molecules26185696
Others
  1. Adib Afandi Abdullah, Yean Kee Lee, Sek Peng Chin, See Khai Lim, Vannajan Sanghiran Lee, Rozana Othman, Shatrah Othman, Noorsaadah Abdul Rahman, Rohana Yusof and Choon Han Heh. (2020). Discovery of Dengue Virus Inhibitors, Current Medicinal Chemistry, 27: 4945-5036.
  2. Gautam V, Chong WL, Chin SP, Zain SM, Rahman NA, Vao-soongnern V, et al. Loop dynamics behind the affinity of DARPins towards ERK2: Molecular dynamics simulations (MDs) and elastic network model (ENM). Journal of Molecular Liquids. 2019;274:612-20
  3. Isa, D. M., Chin, S. P., Chong, W. L., Zain, S. M., Rahman, N. A., & Lee, V. S. (2019). Dynamics and binding interactions of peptide inhibitors of dengue virus entry. J Biol Phys. doi:10.1007/s10867-018-9515-6
  4. Heng HL, Chee CF, Chin SP, Ouyang Y, Wang H, Buckle MJC, et al. Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and 1 receptor antagonists. MedChemComm. 2018.
  5. Heng, H. L., Chee, C. F., Thy, C. K., Tee, J. T., Chin, S. P., Herr, D. R., Buckle, M. J. C., Paterson, I. C., Doughty, S. W., Abd Rahman, N., & Chung, L. Y. (2018). In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and alpha1 receptors. Chem Biol Drug Des. doi:10.1111/cbdd.13390
  6. Oo A, Hassandarvish P, Chin SP, Lee VS, Abu Bakar S, Zandi K. (2016) In silico study on anti- Chikungunya virus activity of hesperetin. PeerJ 4:e2602
  7. Ramasamy, S., Chin, S. P., Sukumaran, S. D., Buckle, M. J., Kiew, L. V., Chung, L. Y (2015). In Silico and In Vitro Analysis of Bacoside A Aglycones and its Derivatives as the Constituents Responsible for the Cognitive Effects of Bacopa monnieri. PLoS One, 10(5): e0126565. doi:10.1371/journal.pone.0126565
  8. Chin, S. P., Buckle, M. J., Chalmers, D. K., Yuriev, E., & Doughty, S. W. (2014). Toward activated homology models of the human M1 muscarinic acetylcholine receptor. Journal of Molecular Graphics and Modelling, 49, 91-98.
  9. Swaminathan, M., Chee, C. F., Chin, S. P., Buckle, M. J., Rahman, N. A., Doughty, S. W., & Chung, L. Y. (2014). Flavonoids with M1 muscarinic acetylcholine receptor binding activity. Molecules, 19(7), 8933-8948.
  10. Chin, S. P., & Wahab, H. (2007). Thermo-effects of methionine aminopeptidase: Molecular dynamics studies. In R. Magjarevic & J. H. Nagel (Eds.), World Congress on Medical Physics and Biomedical Engineering 2006 (Vol. 14, pp. 209-213): Springer Berlin Heidelberg.

RESEARCH PROJECT

National
  1. 2022 - 2025, Fundamental Research Grant Scheme (FRGS)
    Investigating Factors Affecting Aptamer?s Conformation And Target Sensitivity At The Aptamer-graphene Interface And Mechanism Description For Biosensing Applications ( Co-Researcher)
  2. 2022 - 2024, Others MOHE - Top 100 (IIRG)-FNW
    WP2: Development of Novel Therapeutic Agent and Delivery Method for Lung Cancer ( Co-Researcher)
  3. 2021 - 2023, RU Geran
    Interdisciplinary And Target-based Development Of Nutraceuticals And Drugs For Prevention And Treatments Of Diseases ( Principal Investigator(PI))
  4. 2019 - 2022, Fundamental Research Grant Scheme (FRGS)
    Understanding The Mechanism Of Extracellular Release Of ?-synuclein Through Leucine-rich Repeat Kinase 2 (lrrk2) Mutations And Kinase Inhibition ( Co-Researcher)
  5. 2019 - 2022, Others MOHE - Top 100 (IIRG)-FNW
    Design And Development Of Antimicrobial Molecules/anti-virulence Agents For Suppression Of Biofilm Formation Of Staphylococcus Aureus ( Principal Investigator(PI))
  6. 2019 - 2021, Fundamental Research Grant Scheme (FRGS)
    In Silico Self-evolving Peptides Algorithm For The Discovery Of Potential Peptide Inhibitor Against Alpha-amylase And Alpha-glucosidase ( Co-Researcher)
  7. 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG) - AFR (Frontier Science)
    Development Of Highly Potent, Selective, And Brain-penetrant Aminopyridoxamine Leucine-rich Repeat Kinase 2 (lrrk2) Inhibitors For Parkinson S Disease Treatment ( Co-Researcher)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2020) Assessor, (Assessor)
  2. (2019) Invited reviewer of Journal of Chemical Information and Modeling , (Reviewer)
  3. (2018) Invited reviewer of Journal of Computer-Aided Molecular Design , (Reviewer)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2024) Exploring new Angiotensin Converting Enzyme Inhibitors (ACEI)-like structures for the SARS-CoV-2 S-protein – ACE2 Binding inhibition and reduction of SARS-CoV-2 Infectivity, FENGMEI ZUO
  2. (2024) PEPTIDES GENERATION ALGORITHM TARGETING CANCER CELL SURFACE PROPERTIES: IN SILICO & IN VITRO STUDY, ZIRUI WANG
  3. (2024) Design and Evaluation of Novel Inhibitors for Candida Auris Infection, YASMINA ELSAYED MOHAMED MANSOUR LASHIN
Master
  1. (2024) Screening of Novel Indazole-Based Molecules for Parkinson’s Disease-Associated Leucine-Rich Repeat Kinase 2 (LRRKs) and its Variants, Anis Nadhirah Khairul Anuar
  2. (2024) Discovery of potential LRRK2 inhibitors through Al-assisted in silico approaches, CHUANCHENG WEI
  3. (2023) IN SILICO SCREENING TARGETING PARKINSON?S DISEASE-ASSOCIATED LRRK2 WD40 DOMAIN, AIN ZUHAYRA BINTI MUHAMMAD RAZI
  4. (2021) IN SILICO STUDIES OF COMPETITIVE AND NON-COMPETITIVE EGFR-TK INHIBITORS IN LUNG CANCER, TAN KE HAN

TEACHING

Bachelor
  1. (2021) OIA1006 - Drug Action and Discovery
  2. (2021) OIA4009 - Research Project
  3. (2020) OIA3019 - Drug Literacy