Curriculum Vitae

DR. CHIN SEK PENG

Senior Lecturer
  • Department of Pharmaceutical Chemistry
    Faculty of Pharmacy
  • spchin
  • 03-79677831

AREAS OF EXPERTISE


  • BIOMOLECULAR STRUCTURE AND FUNCTION
    Life Sciences, Biological Sciences, Biomolecular Sciences
  • BIOMOLECULAR DOCKING
    Life Sciences, Biological Sciences, Biomolecular Sciences
  • BINDING POCKET MODELLING
    Applied Science And Technology, Bioinformatics, Structural Bioinformatics
  • BIOMOLECULAR INTERACTIONS MODELLING
    Applied Science And Technology, Bioinformatics, Structural Bioinformatics
  • COMPUTER-BASED LEAD COMPOUND DISCOVERY
    Applied Science And Technology, Bioinformatics, Structural Bioinformatics
  • MOLECULAR DOCKING SIMULATION
    Applied Science And Technology, Bioinformatics, Structural Bioinformatics
  • MOLECULAR DYNAMICS SIMULATION
    Applied Science And Technology, Bioinformatics, Structural Bioinformatics
  • PROTEIN INTERACTION NETWORK SIMULATION
    Applied Science And Technology, Bioinformatics, Structural Bioinformatics
  • BIO-MODELLING AND SIMULATION
    Applied Science And Technology, Bioinformatics, Bioinformatics Tools, Platforms And Technologies

ACADEMIC QUALIFICATION


  • PhD (Drug Discovery), (DRUG DISCOVERY)
    Universiti Malaya (UM)
  • MSc (Pharmacy), (FARMASI)
    Universiti Sains Malaysia (USM)
  • BSc (Hons)(BioInfo), (BIOINFORMATIK)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES


  • Committee Members
    01 Oct 2024 - 30 Sep 2027 (University Malaya)
    01 Sep 2023 - 30 Oct 2025 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
    01 Jan 2023 - 31 Dec 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
    01 Jan 2023 - 31 Dec 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Task Force Leader
    01 Apr 2024 - 13 Jun 2024 (University Malaya)
  • Programme Coordinator
    06 Jan 2022 - 16 Jan 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Coordinator
    25 Sep 2023 - 31 Dec 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
    01 Jan 2022 - 31 Dec 2023 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
  • Task Force Member
    22 Nov 2024 - 31 Dec 2025 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
    21 Oct 2024 - 08 Nov 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
    01 Feb 2022 - 31 Oct 2022 (University Malaya)

MEMBERSHIPS


  • MDS MEMBER, MEMBER
    2023 to 2025 (International)

AWARD AND STEWARDSHIP


  • Best Presenter (Young Researcher Category)
    2017, Asia Consortium of Computational Materials Science - 9 (ACCMS-9),  (International)

PUBLICATIONS


Article in Journal
WoS
  1. Manimaran, Malarmugila; Teo, Yin Yin; Kah, James Chen Yong; Beishenaliev, Adilet; Loke, Yean Leng; Foo, Yiing Yee; Ng, Shiow-Fern; Chee, Chin Fei; Chin, Sek Peng; Faruqu, Farid Nazer; Chang, Chia-Yu; Misran, Misni; Chung, Lip Yong; Leo, Bey Fen; Chiou, Shih-Hwa; Chang, Chia-Ching; Tay, Sun Tee; Kiew, Lik Voon (2024). PDADMAC/Alginate-Coated Gold Nanorod For Eradication of Staphylococcus Aureus Biofilms, INTERNATIONAL JOURNAL OF NANOMEDICINE. 19, 3697-3714. doi:10.2147/IJN.S452085
  2. Yap, Cheng Hong; Ramle, Abdul Qaiyum; Lim, See Khai; Rames, Avinash; Tay, Sun Tee; Chin, Sek Peng; Kiew, Lik Voon; Tiekink, Edward R. T.; Chee, Chin Fei (2023). Synthesis and Staphylococcus aureus biofilm inhibitory activity of indolenine-substituted pyrazole and pyrimido[1,2-b]indazole derivatives, BIOORGANIC & MEDICINAL CHEMISTRY. 95. doi:10.1016/j.bmc.2023.117485
  3. Chua, R. A. H. W.; Lim, S. K.; Chee, C. F.; Chin, S. P.; Kiew, L. V.; Sim, K. S.; Tay, S. T. (2022). Surgical site infection and development of antimicrobial sutures: a review, EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. 26(3), 828-845
  4. Tan, Ke Han; Chin, Sek Peng; Heh, Choon Han (2022). Automated in silico EGFR Peptide Inhibitor Elongation using Self-evolving Peptide Algorithm, CURRENT COMPUTER-AIDED DRUG DESIGN. 18(2), 150-158. doi:10.2174/1573409918666220516144300
  5. Chong, W. L., Chupradit, K., Chin, S. P., Khoo, M. M., Khor, S. M., Tayapiwatana, C., . . . Lee, V. S. (2021). Protein-Protein Interactions: Insight from Molecular Dynamics Simulations and Nanoparticle Tracking Analysis. Molecules, 26(18), 13. doi: 10.3390/molecules26185696
  6. Abdullah, A. A., Lee, Y. K., Chin, S. P., Lim, S. K., Lee, V. S., Othman, R., . . . Heh, C. H. (2020). Discovery of Dengue Virus Inhibitors. Current Medicinal Chemistry, 27(30), 4945-5036. doi: 10.2174/0929867326666181204155336
  7. Gautam, V., Chong, W. L., Chin, S. P., Zain, S. M., Rahman, N. A., Vao-soongnern, V., Lee, V. S. (2019). Loop dynamics behind the affinity of DARPins towards ERK2: Molecular dynamics simulations (MDs) and elastic network model (ENM). Journal of Molecular Liquids, 274, 612-620. doi:10.1016/j.molliq.2018.10.157
  8. Heng, H. L., Chee, C. F., Thy, C. K., Tee, J. T., Chin, S. P., Herr, D. R., . . . Chung, L. Y. (2019). In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and alpha(1) receptors. Chemical Biology Drug Design, 93(2), 132-138. doi:10.1111/cbdd.13390
  9. Isa, D. M., Chin, S. P., Chong, W. L., Zain, S. M., Abd Rahman, N., Lee, V. S. (2019). Dynamics and binding interactions of peptide inhibitors of dengue virus entry. Journal of Biological Physics, 45(1), 63-76. doi:10.1007/s10867-018-9515-6
Others
  1. Heng HL, Chee CF, Chin SP, Ouyang Y, Wang H, Buckle MJC, et al. Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and 1 receptor antagonists. MedChemComm. 2018.
  2. Heng, H. L., Chee, C. F., Thy, C. K., Tee, J. T., Chin, S. P., Herr, D. R., Buckle, M. J. C., Paterson, I. C., Doughty, S. W., Abd Rahman, N., & Chung, L. Y. (2018). In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and alpha1 receptors. Chem Biol Drug Des. doi:10.1111/cbdd.13390
  3. Oo A, Hassandarvish P, Chin SP, Lee VS, Abu Bakar S, Zandi K. (2016) In silico study on anti- Chikungunya virus activity of hesperetin. PeerJ 4:e2602
  4. Ramasamy, S., Chin, S. P., Sukumaran, S. D., Buckle, M. J., Kiew, L. V., Chung, L. Y (2015). In Silico and In Vitro Analysis of Bacoside A Aglycones and its Derivatives as the Constituents Responsible for the Cognitive Effects of Bacopa monnieri. PLoS One, 10(5): e0126565. doi:10.1371/journal.pone.0126565
  5. Chin, S. P., Buckle, M. J., Chalmers, D. K., Yuriev, E., & Doughty, S. W. (2014). Toward activated homology models of the human M1 muscarinic acetylcholine receptor. Journal of Molecular Graphics and Modelling, 49, 91-98.
  6. Swaminathan, M., Chee, C. F., Chin, S. P., Buckle, M. J., Rahman, N. A., Doughty, S. W., & Chung, L. Y. (2014). Flavonoids with M1 muscarinic acetylcholine receptor binding activity. Molecules, 19(7), 8933-8948.
  7. Chin, S. P., & Wahab, H. (2007). Thermo-effects of methionine aminopeptidase: Molecular dynamics studies. In R. Magjarevic & J. H. Nagel (Eds.), World Congress on Medical Physics and Biomedical Engineering 2006 (Vol. 14, pp. 209-213): Springer Berlin Heidelberg.

RESEARCH INTEREST


  • I am passionate about using computational methods to study ligand-receptor interactions, focusing on designing and discovering novel drug candidates. My research involves computational modelling and simulation techniques to advance drug discovery and development. Recently, I have begun exploring artificial intelligence to optimise these methodologies further. (Structural bioinformatics, Molecular dynamics simulations, Ligand-receptor interactions, Artificial intelligence)

RESEARCH PROJECT


National
  1. 2022 - 2025, Fundamental Research Grant Scheme (FRGS)
    Investigating Factors Affecting Aptamer?s Conformation And Target Sensitivity At The Aptamer-graphene Interface And Mechanism Description For Biosensing Applications ( Co-Researcher)
  2. 2022 - 2025, Others MOHE - Top 100 (IIRG)-FNW
    Wp2: Development Of Novel Therapeutic Agent And Delivery Method For Lung Cancer ( Co-Researcher)
  3. 2021 - 2023, RU Geran
    Interdisciplinary And Target-based Development Of Nutraceuticals And Drugs For Prevention And Treatments Of Diseases ( Principal Investigator(PI))
  4. 2019 - 2022, Fundamental Research Grant Scheme (FRGS)
    Understanding The Mechanism Of Extracellular Release Of ?-synuclein Through Leucine-rich Repeat Kinase 2 (lrrk2) Mutations And Kinase Inhibition ( Co-Researcher)
  5. 2019 - 2022, Others MOHE - Top 100 (IIRG)-FNW
    Design And Development Of Antimicrobial Molecules/anti-virulence Agents For Suppression Of Biofilm Formation Of Staphylococcus Aureus ( Principal Investigator(PI))
  6. 2019 - 2021, Fundamental Research Grant Scheme (FRGS)
    In Silico Self-evolving Peptides Algorithm For The Discovery Of Potential Peptide Inhibitor Against Alpha-amylase And Alpha-glucosidase ( Co-Researcher)
  7. 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG) - AFR (Frontier Science)
    Development Of Highly Potent, Selective, And Brain-penetrant Aminopyridoxamine Leucine-rich Repeat Kinase 2 (lrrk2) Inhibitors For Parkinson S Disease Treatment ( Co-Researcher)

PAPER PRESENTED


INVITED SPEAKER
  1. Understanding protein-protein interactions and dynamics through in silico approaches, International Conference of Taiwan-South/South Eastern Asia AI-Assisted Drug Discovery and Precision Medicine, National Cheng Kung University, Taiwan (International) (03 Aug 2023 - 03 Aug 2023)
ORAL PRESENTER
  1. Pocket-Aligned Ligand Absolute Conformations Clustering (PALACE): A Relative Position Ligand Conformational Analysis for Molecular Dynamics Simulations., International Conference on Drug Design and Discovery (IC3D), Malaysian Society of Pharmaceutical Technology (International) (13 May 2024 - 14 May 2024)
  2. Exploring the BindingPocket of Dengue 2 Envelope Protein: Insight from The Molecular Dynamics Study., 9th Asian Consortiumon Computational Material Science (ACCMS-9), University of Malaya (International) (09 Aug 2017 - 11 Aug 2017)
  3. Molecular Dynamics Simulations of Huma M1 Muscarinic Acetylcholine Receptor., 16th Biological Sciences GraduateConference (BSGC), National University of Singapore, Singapore (International) (12 Dec 2011 - 14 Dec 2011)
POSTER PRESENTER
  1. LRRK2 INHIBITOR PREDICTOR: ACCELERATING LRRK2 INHIBITOR DISCOVERY WITH MORGAN-BASED MACHINE LEARNING MODELS., Research Day 2024, PG Unit and PG Society, Faculty of Pharmacy (University) (07 May 2024 - 07 May 2024)
  2. Identification of 5-Phenylindazoles As Potential Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors and Degraders for Parkinson's Disease Associated LRRK2 via Computational and In Vitro Approaches, ICKMDS 2023, Korean Movement Disorder Society (International) (01 Dec 2023 - 02 Dec 2023)
  3. Homology modeling of humanM1 muscarinic acetylcholine receptor., 12th Association of Pacific Rim Universities Doctoral Student Conference (APRU DSC), TsingHua University (International) (04 Jul 2011 - 07 Jul 2011)

SUPERVISION


Postgraduate Student
PhD/ Doctoral
  1. (2024) Exploring new Angiotensin Converting Enzyme Inhibitors (ACEI)-like structures for the SARS-CoV-2 S-protein – ACE2 Binding inhibition and reduction of SARS-CoV-2 Infectivity, FENGMEI ZUO
  2. (2024) PEPTIDES GENERATION ALGORITHM TARGETING CANCER CELL SURFACE PROPERTIES: IN SILICO & IN VITRO STUDY, ZIRUI WANG
  3. (2024) Design and Evaluation of Novel Inhibitors for Candida Auris Infection, YASMINA ELSAYED MOHAMED MANSOUR LASHIN
Master
  1. (2024) Screening of Novel Indazole-Based Molecules for Parkinson’s Disease-Associated Leucine-Rich Repeat Kinase 2 (LRRKs) and its Variants, Anis Nadhirah Khairul Anuar
  2. (2024) Discovery of potential LRRK2 inhibitors through Al-assisted in silico approaches, CHUANCHENG WEI
  3. (2023) IN SILICO SCREENING TARGETING PARKINSON?S DISEASE-ASSOCIATED LRRK2 WD40 DOMAIN, AIN ZUHAYRA BINTI MUHAMMAD RAZI
  4. (2021) IN SILICO STUDIES OF COMPETITIVE AND NON-COMPETITIVE EGFR-TK INHIBITORS IN LUNG CANCER, TAN KE HAN

TEACHING


Master
  1. (2024) OQB7006 - Advanced Medicinal Chemistry
  2. (2024) OQB7005 - Pharmaceutical Bioinformatics
  3. (2024) OQB7007 - Pharmacogenomics, Pharmacokinetics and Pharmacodynamics in Precision Medicine
  4. (2024) OMX7001 - Research Methodology
Bachelor
  1. (2024) OIA2012 - Medicinal Chemistry
  2. (2024) OIA1016 - Pharmacoinformatics
  3. (2023) OIA1011 - Basic Pharmaceutical Chemistry
  4. (2023) OIA4009 - Research Project
  5. (2021) OIA1006 - Drug Action and Discovery
  6. (2021) OIA4009 - Research Project
  7. (2020) OIA3019 - Drug Literacy

PATENT/IPR


  • AN INDOLENINE DERIVATIVE FOR INHIBITING BIOFILM FORMATION BY STAPHYLOCOCCUS AUREUS
    PATENT
  • Pathogenic Bacterial Biofilm Disruption Composition
    PATENT
  • Self-evolving Peptide Algorithm
    COPYRIGHT
  • A CENTRAL NERVOUS SYSTEM (CNS) DRUG FOR TREATMENT OF ALZHEIMER S DISEASE
    PATENT