
Curriculum Vitae
AREAS OF EXPERTISE
- BIOMOLECULAR STRUCTURE AND FUNCTIONLife Sciences, Biological Sciences, Biomolecular Sciences
- BIOMOLECULAR DOCKINGLife Sciences, Biological Sciences, Biomolecular Sciences
- BINDING POCKET MODELLINGApplied Science And Technology, Bioinformatics, Structural Bioinformatics
- BIOMOLECULAR INTERACTIONS MODELLINGApplied Science And Technology, Bioinformatics, Structural Bioinformatics
- COMPUTER-BASED LEAD COMPOUND DISCOVERYApplied Science And Technology, Bioinformatics, Structural Bioinformatics
- MOLECULAR DOCKING SIMULATIONApplied Science And Technology, Bioinformatics, Structural Bioinformatics
- MOLECULAR DYNAMICS SIMULATIONApplied Science And Technology, Bioinformatics, Structural Bioinformatics
- PROTEIN INTERACTION NETWORK SIMULATIONApplied Science And Technology, Bioinformatics, Structural Bioinformatics
- BIO-MODELLING AND SIMULATIONApplied Science And Technology, Bioinformatics, Bioinformatics Tools, Platforms And Technologies
ACADEMIC QUALIFICATION
- PhD (Drug Discovery), (DRUG DISCOVERY)Universiti Malaya (UM)
- MSc (Pharmacy), (FARMASI)Universiti Sains Malaysia (USM)
- BSc (Hons)(BioInfo), (BIOINFORMATIK)Universiti Malaya (UM)
ADMINISTRATIVE DUTIES
- Committee Members01 Oct 2024 - 30 Sep 2027 (University Malaya)01 Sep 2023 - 30 Oct 2025 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)01 Jan 2023 - 31 Dec 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)01 Jan 2023 - 31 Dec 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
- Task Force Leader01 Apr 2024 - 13 Jun 2024 (University Malaya)
- Programme Coordinator06 Jan 2022 - 16 Jan 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
- Coordinator25 Sep 2023 - 31 Dec 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)01 Jan 2022 - 31 Dec 2023 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)
- Task Force Member22 Nov 2024 - 31 Dec 2025 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)21 Oct 2024 - 08 Nov 2024 (Department of Pharmaceutical Chemistry, Faculty of Pharmacy)01 Feb 2022 - 31 Oct 2022 (University Malaya)
MEMBERSHIPS
- MDS MEMBER, MEMBER2023 to 2025 (International)
AWARD AND STEWARDSHIP
- Best Presenter (Young Researcher Category)2017, Asia Consortium of Computational Materials Science - 9 (ACCMS-9), (International)
PUBLICATIONS
Article in Journal
WoS
-
Manimaran, Malarmugila; Teo, Yin Yin; Kah, James Chen Yong; Beishenaliev, Adilet; Loke, Yean Leng; Foo, Yiing Yee; Ng, Shiow-Fern; Chee, Chin Fei; Chin, Sek Peng; Faruqu, Farid Nazer; Chang, Chia-Yu; Misran, Misni; Chung, Lip Yong; Leo, Bey Fen; Chiou, Shih-Hwa; Chang, Chia-Ching; Tay, Sun Tee; Kiew, Lik Voon (2024). PDADMAC/Alginate-Coated Gold Nanorod For Eradication of Staphylococcus Aureus Biofilms, INTERNATIONAL JOURNAL OF NANOMEDICINE. 19, 3697-3714. doi:10.2147/IJN.S452085
-
Yap, Cheng Hong; Ramle, Abdul Qaiyum; Lim, See Khai; Rames, Avinash; Tay, Sun Tee; Chin, Sek Peng; Kiew, Lik Voon; Tiekink, Edward R. T.; Chee, Chin Fei (2023). Synthesis and Staphylococcus aureus biofilm inhibitory activity of indolenine-substituted pyrazole and pyrimido[1,2-b]indazole derivatives, BIOORGANIC & MEDICINAL CHEMISTRY. 95. doi:10.1016/j.bmc.2023.117485
-
Chua, R. A. H. W.; Lim, S. K.; Chee, C. F.; Chin, S. P.; Kiew, L. V.; Sim, K. S.; Tay, S. T. (2022). Surgical site infection and development of antimicrobial sutures: a review, EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES. 26(3), 828-845
-
Tan, Ke Han; Chin, Sek Peng; Heh, Choon Han (2022). Automated in silico EGFR Peptide Inhibitor Elongation using Self-evolving Peptide Algorithm, CURRENT COMPUTER-AIDED DRUG DESIGN. 18(2), 150-158. doi:10.2174/1573409918666220516144300
-
Chong, W. L., Chupradit, K., Chin, S. P., Khoo, M. M., Khor, S. M., Tayapiwatana, C., . . . Lee, V. S. (2021). Protein-Protein Interactions: Insight from Molecular Dynamics Simulations and Nanoparticle Tracking Analysis. Molecules, 26(18), 13. doi: 10.3390/molecules26185696
-
Abdullah, A. A., Lee, Y. K., Chin, S. P., Lim, S. K., Lee, V. S., Othman, R., . . . Heh, C. H. (2020). Discovery of Dengue Virus Inhibitors. Current Medicinal Chemistry, 27(30), 4945-5036. doi: 10.2174/0929867326666181204155336
-
Gautam, V., Chong, W. L., Chin, S. P., Zain, S. M., Rahman, N. A., Vao-soongnern, V., Lee, V. S. (2019). Loop dynamics behind the affinity of DARPins towards ERK2: Molecular dynamics simulations (MDs) and elastic network model (ENM). Journal of Molecular Liquids, 274, 612-620. doi:10.1016/j.molliq.2018.10.157
-
Heng, H. L., Chee, C. F., Thy, C. K., Tee, J. T., Chin, S. P., Herr, D. R., . . . Chung, L. Y. (2019). In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and alpha(1) receptors. Chemical Biology Drug Design, 93(2), 132-138. doi:10.1111/cbdd.13390
-
Isa, D. M., Chin, S. P., Chong, W. L., Zain, S. M., Abd Rahman, N., Lee, V. S. (2019). Dynamics and binding interactions of peptide inhibitors of dengue virus entry. Journal of Biological Physics, 45(1), 63-76. doi:10.1007/s10867-018-9515-6
Others
-
Heng HL, Chee CF, Chin SP, Ouyang Y, Wang H, Buckle MJC, et al. Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and 1 receptor antagonists. MedChemComm. 2018.
-
Heng, H. L., Chee, C. F., Thy, C. K., Tee, J. T., Chin, S. P., Herr, D. R., Buckle, M. J. C., Paterson, I. C., Doughty, S. W., Abd Rahman, N., & Chung, L. Y. (2018). In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and alpha1 receptors. Chem Biol Drug Des. doi:10.1111/cbdd.13390
-
Oo A, Hassandarvish P, Chin SP, Lee VS, Abu Bakar S, Zandi K. (2016) In silico study on anti- Chikungunya virus activity of hesperetin. PeerJ 4:e2602
-
Ramasamy, S., Chin, S. P., Sukumaran, S. D., Buckle, M. J., Kiew, L. V., Chung, L. Y (2015). In Silico and In Vitro Analysis of Bacoside A Aglycones and its Derivatives as the Constituents Responsible for the Cognitive Effects of Bacopa monnieri. PLoS One, 10(5): e0126565. doi:10.1371/journal.pone.0126565
-
Chin, S. P., Buckle, M. J., Chalmers, D. K., Yuriev, E., & Doughty, S. W. (2014). Toward activated homology models of the human M1 muscarinic acetylcholine receptor. Journal of Molecular Graphics and Modelling, 49, 91-98.
-
Swaminathan, M., Chee, C. F., Chin, S. P., Buckle, M. J., Rahman, N. A., Doughty, S. W., & Chung, L. Y. (2014). Flavonoids with M1 muscarinic acetylcholine receptor binding activity. Molecules, 19(7), 8933-8948.
-
Chin, S. P., & Wahab, H. (2007). Thermo-effects of methionine aminopeptidase: Molecular dynamics studies. In R. Magjarevic & J. H. Nagel (Eds.), World Congress on Medical Physics and Biomedical Engineering 2006 (Vol. 14, pp. 209-213): Springer Berlin Heidelberg.
RESEARCH INTEREST
- I am passionate about using computational methods to study ligand-receptor interactions, focusing on designing and discovering novel drug candidates. My research involves computational modelling and simulation techniques to advance drug discovery and development. Recently, I have begun exploring artificial intelligence to optimise these methodologies further. (Structural bioinformatics, Molecular dynamics simulations, Ligand-receptor interactions, Artificial intelligence)
RESEARCH PROJECT
National
- 2022 - 2025, Fundamental Research Grant Scheme (FRGS)Investigating Factors Affecting Aptamer?s Conformation And Target Sensitivity At The Aptamer-graphene Interface And Mechanism Description For Biosensing Applications ( Co-Researcher)
- 2022 - 2025, Others MOHE - Top 100 (IIRG)-FNWWp2: Development Of Novel Therapeutic Agent And Delivery Method For Lung Cancer ( Co-Researcher)
- 2021 - 2023, RU GeranInterdisciplinary And Target-based Development Of Nutraceuticals And Drugs For Prevention And Treatments Of Diseases ( Principal Investigator(PI))
- 2019 - 2022, Fundamental Research Grant Scheme (FRGS)Understanding The Mechanism Of Extracellular Release Of ?-synuclein Through Leucine-rich Repeat Kinase 2 (lrrk2) Mutations And Kinase Inhibition ( Co-Researcher)
- 2019 - 2022, Others MOHE - Top 100 (IIRG)-FNWDesign And Development Of Antimicrobial Molecules/anti-virulence Agents For Suppression Of Biofilm Formation Of Staphylococcus Aureus ( Principal Investigator(PI))
- 2019 - 2021, Fundamental Research Grant Scheme (FRGS)In Silico Self-evolving Peptides Algorithm For The Discovery Of Potential Peptide Inhibitor Against Alpha-amylase And Alpha-glucosidase ( Co-Researcher)
- 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG) - AFR (Frontier Science)Development Of Highly Potent, Selective, And Brain-penetrant Aminopyridoxamine Leucine-rich Repeat Kinase 2 (lrrk2) Inhibitors For Parkinson S Disease Treatment ( Co-Researcher)
PAPER PRESENTED
INVITED SPEAKER
- Understanding protein-protein interactions and dynamics through in silico approaches, International Conference of Taiwan-South/South Eastern Asia AI-Assisted Drug Discovery and Precision Medicine, National Cheng Kung University, Taiwan (International) (03 Aug 2023 - 03 Aug 2023)
ORAL PRESENTER
- Pocket-Aligned Ligand Absolute Conformations Clustering (PALACE): A Relative Position Ligand Conformational Analysis for Molecular Dynamics Simulations., International Conference on Drug Design and Discovery (IC3D), Malaysian Society of Pharmaceutical Technology (International) (13 May 2024 - 14 May 2024)
- Exploring the BindingPocket of Dengue 2 Envelope Protein: Insight from The Molecular Dynamics Study., 9th Asian Consortiumon Computational Material Science (ACCMS-9), University of Malaya (International) (09 Aug 2017 - 11 Aug 2017)
- Molecular Dynamics Simulations of Huma M1 Muscarinic Acetylcholine Receptor., 16th Biological Sciences GraduateConference (BSGC), National University of Singapore, Singapore (International) (12 Dec 2011 - 14 Dec 2011)
POSTER PRESENTER
- LRRK2 INHIBITOR PREDICTOR: ACCELERATING LRRK2 INHIBITOR DISCOVERY WITH MORGAN-BASED MACHINE LEARNING MODELS., Research Day 2024, PG Unit and PG Society, Faculty of Pharmacy (University) (07 May 2024 - 07 May 2024)
- Identification of 5-Phenylindazoles As Potential Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors and Degraders for Parkinson's Disease Associated LRRK2 via Computational and In Vitro Approaches, ICKMDS 2023, Korean Movement Disorder Society (International) (01 Dec 2023 - 02 Dec 2023)
- Homology modeling of humanM1 muscarinic acetylcholine receptor., 12th Association of Pacific Rim Universities Doctoral Student Conference (APRU DSC), TsingHua University (International) (04 Jul 2011 - 07 Jul 2011)
SUPERVISION
Postgraduate Student
PhD/ Doctoral
-
(2024) Exploring new Angiotensin Converting Enzyme Inhibitors (ACEI)-like structures for the SARS-CoV-2 S-protein – ACE2 Binding inhibition and reduction of SARS-CoV-2 Infectivity, FENGMEI ZUO
-
(2024) PEPTIDES GENERATION ALGORITHM TARGETING CANCER CELL SURFACE PROPERTIES: IN SILICO & IN VITRO STUDY, ZIRUI WANG
-
(2024) Design and Evaluation of Novel Inhibitors for Candida Auris Infection, YASMINA ELSAYED MOHAMED MANSOUR LASHIN
Master
-
(2024) Screening of Novel Indazole-Based Molecules for Parkinson’s Disease-Associated Leucine-Rich Repeat Kinase 2 (LRRKs) and its Variants, Anis Nadhirah Khairul Anuar
-
(2024) Discovery of potential LRRK2 inhibitors through Al-assisted in silico approaches, CHUANCHENG WEI
-
(2023) IN SILICO SCREENING TARGETING PARKINSON?S DISEASE-ASSOCIATED LRRK2 WD40 DOMAIN, AIN ZUHAYRA BINTI MUHAMMAD RAZI
-
(2021) IN SILICO STUDIES OF COMPETITIVE AND NON-COMPETITIVE EGFR-TK INHIBITORS IN LUNG CANCER, TAN KE HAN
TEACHING
Master
- (2024) OQB7006 - Advanced Medicinal Chemistry
- (2024) OQB7005 - Pharmaceutical Bioinformatics
- (2024) OQB7007 - Pharmacogenomics, Pharmacokinetics and Pharmacodynamics in Precision Medicine
- (2024) OMX7001 - Research Methodology
Bachelor
- (2024) OIA2012 - Medicinal Chemistry
- (2024) OIA1016 - Pharmacoinformatics
- (2023) OIA1011 - Basic Pharmaceutical Chemistry
- (2023) OIA4009 - Research Project
- (2021) OIA1006 - Drug Action and Discovery
- (2021) OIA4009 - Research Project
- (2020) OIA3019 - Drug Literacy
PATENT/IPR
- AN INDOLENINE DERIVATIVE FOR INHIBITING BIOFILM FORMATION BY STAPHYLOCOCCUS AUREUSPATENT
- Pathogenic Bacterial Biofilm Disruption CompositionPATENT
- Self-evolving Peptide AlgorithmCOPYRIGHT
- A CENTRAL NERVOUS SYSTEM (CNS) DRUG FOR TREATMENT OF ALZHEIMER S DISEASEPATENT