Institute of Biological Sciences
Faculty of Science
 Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, W.Persekutuan Kuala Lumpur, Malaysia
ResearcherID Link


 Total Articles in Publication List  40
 Articles With Citation Data  40
 Sum of the Times Cited   453
 Average Citations per Article   11.32
 h-index   13
 Co-authors   Collaboration Network
 This information is generated from

(Qualification), (Institution).

(Organisation), (Role), (Year), (Level).

  • Malaysian Society of Marine Science, Member, 2012 to 2015, (National)
  • Malaysian Society for Biochemistry and Molecular Biology , Member, 2013 to 2021, (National)

(Role), (Level), (Start date),(End Date).

  • Panel Penasihat Akademik Fakulti Sains Sesi 2019/2020 , Faculty, 01/09/2019 to 13/09/2020
  • Ahli Jawatankuasa Jadual Waktu Kuliah & Peperiksaan, Institut Sains Biologi, Fakulti Sains, Universiti Malaya, Sesi 2019/2020 dan 2020/2021, Faculty, 30/08/2019 to 31/12/2021
  • Penyelaras Kelab Pelajar Program Biokimia, Institut Sains Biologi, Fakulti Sains, UM, Faculty, 25/03/2019 to 25/03/2021
  • Penyelaras Program Sains Pendidikan (Biologi), Fakulti Sains, Universiti Malaya, Faculty, 18/03/2019 to 30/06/2020
  • Mentor of Buddhist Society University of Malaya (Persatuan Buddhis Universiti Malaya), University Malaya, 26/04/2016 to 13/09/2020
  • Head Coordinator of Industrial Training, Institute of Biological Sciences, Faculty of Science, University of Malaya, Faculty, 14/02/2011 to 31/08/2016 (Session 2010/2011 to session 2015/2016)


  • In Vitro (Cell Culture Based) Drug Testing
  • Cancer Chemoprevention
  • Inorganic Biochemistry
  • Natural Products
  • Drug Discovery


Article in Academic Journals

  • Yong W-K, Lim P-E, Vello V, Sim K-S, Abdul Majid N, Mustafa EM, Nik Sulaiman NM, Liew K-E, Chen BJ-T, Phang SM. (2019) Metabolic and physiological regulation of Chlorella sp. (Trebouxiophyceae, Chlorophyta) under nitrogen deprivation. Journal of Oceanology and Limnology, 37(1): 186-198. (ISI-Indexed)
  • Yeap J S-Y, Mat Saad H, Tan C-H, Sim K-S, Lim S-H, Low Y-Y, Kam T-S. 2019. Macroline−Sarpagine bisindole alkaloids with antiproliferative activity from Alstonia penangiana, Journal of Natural Products, 82, 3121-3132. (ISI-Indexed)
  • Wong S-K, Wong S-P, Sim K-S, Lim S-H, Low Y-Y, Kam T-S. 2019. A Cytotoxic Indole Characterized by Incorporation of a Unique Carbon−Nitrogen Skeleton and Two Pentacyclic Corynanthean Alkaloids Incorporating a Substituted Tetrahydrofuranone Ring from Kopsia arborea. Journal of Natural Products, 82 (7): 1902-1907. (ISI-Indexed)
  • Yong W-K, Sim K-S, Poong S-W, Wei D, Phang S-M, Lim P-E. 2019. Physiological and metabolic responses of Scenedesmus quadricauda (Chlorophyceae) to nickel toxicity and warming. 3 Biotech, 9, 315. (ISI-Indexed)
  • Mohd Amin NA, Duali Hussen RS, Lee SM, Sim KS, Navanesan S. 2019. Synthesis, structural characterization, cytotoxicity and encapsulation studies of N,Nʹ-(1,2-dicyano-1,2-vinylene)-bis(4-hydroxysalicylideneaminato)di(p-chlorobenzyl)tin as potential anticancer drug. Main Group Metal Chemistry, 42, 94-101. (ISI-Indexed)
  • Sim D S-Y, Navanesan S, Sim K-S, Gurusamy S, Lim S-H, Low Y-Y, Kam T-S. 2019. Conolodinines A−D, Aspidosperma−Aspidosperma bisindole alkaloids with antiproliferative activity from Tabernaemontana corymbosa. Journal of Natural Products, 82: 850-858. (ISI-Indexed)

  • Saw WS, Ujihara M, Chong WY, Voon SH, Imae T, Kiew LV, Lee HB, Sim KS, Chung LY. 2018. Size-dependent effect of cystine/citric acid-capped confeito-like gold nanoparticles on cellular uptake and photothermal cancer therapy. Colloids and Surfaces B: Biointerfaces, 161: 365-374. (ISI-Indexed)
  • Yeap JS, Navanesan S, Sim KS, Yong KT, Gurusamy S, Lim SH, Low YY, Kam TS. 2018. Ajmaline, oxindole, and cytotoxic macroline−akuammiline bisindole alkaloids from Alstonia penangiana. Journal of Natural Products, 81(5): 1266-1277. (ISI-Indexed)
  • Mat Saad H, Sim KS, Tan YS. 2018. Antimelanogenesis and anti-inflammatory activity of selected culinary-medicinal mushroom. International Journal of Medicinal Mushrooms, 20(2): 141–153. (ISI-Indexed)
  • Yong W-K, Sim K-S, Poong S-W, Wei D, Phang S-M, Lim P-E. 2018. Interactive effects of temperature and copper toxicity on photosynthetic efficiency and metabolic plasticity in Scenedesmus quadricauda (Chlorophyceae). Journal of Applied Phycology 30 (6): 3029–3041 (ISI-Indexed)
  • Teoh WY, Wahab NA, Sim KS. 2018. Caffeoylquinic acids induce cell death and cell cycle arrest on HCT 116 cells via formation of extracellular H2O2 and oxidation products. Chiang Mai Journal of Science, 45(1): 318-330. (ISI-Indexed)

  • Teoh WY, Wahab NA, Sim KS. 2017. Anti-proliferation effect of Guanosine on HCT 116 cells involves MAPK and AMPK pathways. Nucleosides, Nucleotides and Nucleic Acids,36(4): 243-255. (ISI-Indexed)
  • Sinniah SK, Tan KW, Ng SW, Sim KS. 2017. Cationic Schiff base derivative induces In vitro apoptosis in metastatic PC-3 cells via activation of mitochondrial pathway. Anti-Cancer Agents in Medicinal Chemistry, 17(5): 741-753. (ISI-Indexed)
  • Navanesan S, Abdul Wahab N, Manickam S, Cheow YL, Sim KS. 2017. Intrinsic capabilities of Leptospermum javanicum in inducing apoptosis and suppressing the metastatic potential of human lung carcinoma cells. Chemico-Biological Interactions, 273: 37-47. (ISI-Indexed)
  • Sinniah SK, Sim KS, Ng SW, Tan KW. 2017. Structural and cytotoxic studies of cationic thiosemicarbazones. Journal of Molecular Structure, 1137: 253-259. (ISI-Indexed)

  • Nge C-E, Sim K-S, Lim S-H, Thomas NF, Low Y-Y, Kam T-S. 2016. A Hexacyclic, Iboga-Derived Monoterpenoid Indole with a Contracted Tetrahydroazepine C Ring and Incorporation of an Isoxazolidine Moiety, a Seco-Corynanthean, an Aspidosperma- Aspidosperma Bisindole with Anticancer Properties, and the Absolute Configuration of the Pyridopyrimidine Indole Alkaloid, Vernavosine. Journal of Natural Products, 79: 2709-2717. (ISI-Indexed)
  • Yap W-S, Gan C-Y, Sim K-S, Lim S-H, Low Y-Y, Kam T-S. 2016. Aspidofractinine and Eburnane Alkaloids from a North Borneo Kopsia. Ring-Contracted, Additional Ring-Fused, and PaucidactineType Aspidofractinine Alkaloids from K. pauciflora. Journal of Natural Products. 79(1): 230-239. (ISI-Indexed)
  • Yap A-C, Chan K-G, Sim K-S, Choo Y-M. 2016. A new oxolane from Enterobacter cloacae. Natural Product Research, 30(7): 783-788. (ISI-Indexed)
  • Teoh WY, Tan HP, Ling SK, Wahab NA, Sim KS. 2016. Phytochemical investigation of Gynura bicolor leaves and cytotoxicity evaluation of the chemical constituents against HCT 116 cells. Natural Product Research, 30(4): 448-451. (ISI-Indexed)
  • Teoh WY, Wahab NA, Richardson JSM, Sim KS. 2016. Evaluation of antioxidant properties, cytotoxicity and acute oral toxicity of Gynura procumbens (Compositae). Sains Malaysiana, 45(2): 229-235. (ISI-Indexed)
  • Sim D S-Y, Teoh W-Y, Sim K-S, Lim S-H, Thomas NF, Low Y-Y, Kam T-S. 2016. Vobatensines A−F, Cytotoxic Iboga-Vobasine Bisindoles from Tabernaemontana corymbosa. Journal of Natural Products, 79(4): 1048-1055. (ISI-Indexed)
  • Yap VA, Qazzaz ME, Raja VJ, Bradshaw TD, Loh H-S, Sim K-S, Yong K-T, Low Y-Y, Lim K-H. 2016. Fistulopsines A and B antiproliferative septicine-type alkaloids from Ficus fistulosa. Phytochemistry Letters, 15: 136 141. (ISI-Indexed)

  • Navanesan S, Wahab NA, Manickam S, Sim KS. 2015. Evaluation of selected biological capacities of Baeckea frutescens. BMC Complementary and Alternative Medicine, 15:186. (ISI-Indexed)
  • Navanesan S, Wahab NA, Manickam S, Sim KS. 2015. Leptospermum flavescens constituent-LF1 causes cell death through the induction of cell cycle arrest and apoptosis in human lung carcinoma cells. PLoS ONE, 10(8): e0135995. (ISI-Indexed)
  • Heng MP, Sinniah SK, Teoh WY, Sim KS, Ng SW, Cheah Y K, Tan KW. 2015. Synthesis of a DNA-targeting nickel (II) complex with testosterone thiosemicarbazone which exhibits selective cytotoxicity towards human prostate cancer cells (LNCaP). Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 150: 360-372. (ISI-Indexed)
  • Lee SM, Sim KS, Lo KM. 2015. Synthesis, characterization and biological studies of diorganotin(IV) complexes with tris[(hydroxymethyl)aminomethane] Schiff bases. Inorganica Chimica Acta, 429: 195-208. (ISI-Indexed)
  • Yap AC, Teoh WY, Kok-Gan Chan, Sim KS, Choo YM. 2015. A new oxathiolane from Enterobacter cloacae. Natural Product Research, 29 (8): 722-726. (ISI-Indexed)
  • Lim J-L, Sim K-S, Yong K-T, Loong B-J, Ting K-N, Lim S-H, Low Y-Y, Kam T-S. 2015. Biologically active vallesamine, strychnan, and rhazinilam alkaloids from Alstonia: Pneumatophorine, a nor- secovallesamine with unusual incorporation of a 3- ethylpyridine moiety. Phytochemistry, 117: 317-324. (ISI-Indexed)

  • Lim S-H, Low Y-Y, Sinniah SK, Yong K-T, Sim K-S, Kam T-S. 2014. Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla. Phytochemistry, 98: 204-215. (ISI-Indexed)
  • Chew ST, Lo KM, Sinniah SK, Sim KS, Tan KW. 2014. Synthesis, characterization and biological evaluation of cationic hydrazone copper complexes with diverse co-ligands. RSC Advances. 4(106): 61232- 61247. (ISI-Indexed)
  • Chew ST, Lo KM, Lee SK, Heng MP, Teoh WY, Sim KS, Tan KW. 2014. Copper complexes with phosphonium containing hydrazone ligand: Topoisomerase inhibition and cytotoxicity study. European Journal of Medicinal Chemistry, 76: 397-407. (ISI-Indexed)
  • Sim, K.S., Ibrahim, H., Malek, S.N.A., Syamsir, D.R. & Awang, K. 2014. Cytotoxic Activity of Alpinia murdochii Ridl.:A Mountain Ginger Species from Peninsular Malaysia. Pharmacognosy Magazine 10(37):70-72. (ISI-Indexed)
  • Tan S-J, Lim J-L, Low Y-Y, Sim K-S, Lim S-H, Kam T-S. 2014. Oxidized Derivatives of Macroline, Sarpagine, and Pleiocarpamine Alkaloids from Alstonia angustifolia. Journal of Natural Products, 77: 2068−2080. (ISI-Indexed)
  • Gan C-Y, Yoganathan K, Sim K-S, Low Y-Y, Lim S-H, Kam T-S. 2014. Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora. Phytochemistry, 108: 234-242. (ISI-Indexed)
  • Sim D S-Y, Chong K-W, Nge C-E, Low Y-Y, Sim K-S, Kam T-S. 2014. Cytotoxic Vobasine, Tacaman, and Corynanthe-Tryptamine Bisindole Alkaloids from Tabernaemontana and structure revision of Tronoharine. Journal of Natural Products, 77: 2504-2512. (ISI-Indexed)

  • Lee SM, Mohd Ali H, Sim KS, Abdul Malek SN, Lo KM. 2013. Synthesis, characterization and biological activity of diorganotin complexes with ONO terdentate Schiff base. Inorganica Chimica Acta, 406: 272-278. (ISI-Indexed)
  • Teoh WY, Sim KS, Richardson JSM, Wahab NA, Hoe SZ. 2013. Antioxidant capacity, cytotoxicity, and acute oral toxicity of Gynura bicolor. Evidence-Based Complementary and Alternative Medicine. Volume 2013, Article ID 958407, 10 pages. (ISI-Indexed)
  • Reddy AS, Malek SNA, Ibrahim H, Sim KS. 2013. Cytotoxic effect of Alpinia scabra (Blume) Naves extracts on human breast and ovarian cancer cells. BMC Complementary and Alternative Medicine, 13:314. (ISI-Indexed)

  • Reddy NS, Navanesan S, Sinniah SK, Wahab NA and Sim KS. 2012. Phenolic content, antioxidant effect and cytotoxic activity of Leea indica leaves. BMC Complementary and Alternative Medicine, 12: 128. (ISI-Indexed)
  • Lee SM, Mohd Ali H, Sim KS, Abdul Malek SN, Lo KM. 2012. Synthesis, structural characterization and in vitro cytotoxicity of diorganotin complexes with schiff base ligands derived from 3-hydroxy-2- naphthoylhydrazide. Applied Organometallic Chemistry, 26: 310-319. (ISI-Indexed)

  • Sinniah SK, Tan KW, Sim KS, Ng SW, Tiekink ERT. 2011. [3- ({(E)-2-[(4-Fluorophenyl) carbamothioyl]hydrazinylidene}methyl)-4- hydroxybenzyl]methyltriphenylphosphonium chloride. Acta Crystallographica Section E, E67: o3330-o3331. (ISI-Indexed)
  • Malek SNA, Phang CW, Ibrahim H, Wahab NA, Sim KS. 2011. Phytochemical and cytotoxic investigations of Alpinia mutica rhizomes. Molecules, 16(1): 583-589. (ISI-Indexed)

  • Sim KS, Sri Nurestri AM, Sinniah SK, Kim KH, Norhanom AW. 2010. Acute oral toxicity of Pereskia bleo and Pereskia grandifolia in mice. Pharmacognosy Magazine, 6(21): 67- 70. (ISI-Indexed)
  • Sim KS, Sri Nurestri AM, Norhanom AW. 2010. Phenolic content and antioxidant activity of crude and fractionated extracts of Pereskia bleo (Kunth) DC. (Cactaceae). African Journal of Pharmacy and Pharmacology, 4(5): 193-201. (ISI-Indexed)
  • Ibrahim H, Sim KS, Syamsir DR, Mohd Nor NR, Sri Nurestri AM, Awang K. 2010. Cytotoxic activity of leaf and rhizome extracts of Alpinia scabra (Blume) Naves, a wild ginger from Peninsular Malaysia. African Journal of Pharmacy and Pharmacology, 4(10): 708-711. (ISI-Indexed)
  • Sim KS, Sri Nurestri AM, Norhanom AW. 2010. Phenolic content and antioxidant activity of Pereskia grandifolia Haw. (Cactaceae) extracts. Pharmacognosy Magazine, 6(23): 248-254. (ISI-Indexed)

  • Sri Nurestri AM, Sim KS, Norhanom AW. 2009. Phytochemical and cytotoxic investigations of Pereskia grandifolia Haw. (Cactaceae) leaves. Journal of Biological Sciences, 9(5): 488-493. (SCOPUS-Indexed)
  • Phillip K, Malek SNA, Sani W, Shin SK, Sinniah SK, Lai HS, Serm LG, Rahman SNSA. 2009. Antimicrobial activity of some medicinal plants from Malaysia. American Journal of Applied Sciences, 6(6): 1047-1058. (SCOPUS-Indexed)
  • Malek SNA, Shin SK, Wahab NA, Yaacob H. 2009. Cytotoxic components of Pereskia bleo (Kunth) DC. (Cactaceae) leaves. Molecules, 14: 1713-1724. (ISI-Indexed)

  • Malek SNA, Wahab NA, Yaacob H, Shin SK, Lai HS, Serm LG, Rahman SNSA. (2008). Cytotoxic activity of Pereskia bleo (Cactaceae) against selected human cell lines. International Journal of Cancer Research, 4(1): 20-27. (SCOPUS-Indexed)

(Project title), (Role), (From)-(Until), (Level), (Source).

  • Mechanistic Insight Into Potential Neuroprotective Candidate, Malaysian Mushroom Amauroderma Rugosum (cendawan Budak Sawan) Against Epileptogenesis In In Vitro: A Cross-talk Between Glia And Neurons, Consultant, 2019 - 2021, Fundamental Research Grant Scheme (FRGS), (National)
  • Multi-targeted Therapy Of Malaria By Metal Chelators And Complexes, Consultant, 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - AFR (Frontier Science), (University)
  • Biological Studies Of Synthetic Compounds (bisbenzopyrans, Bisbenzofurans, Oxocines, And Structural Analogs) And Natural Compounds (indole And Bisindole Derivatives) For Reversal Of Multidrug Resistance And Antiproliferative Activity Against Human Cancer Cells, Principal Investigator(PI), 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - AFR (Frontier Science), (University)
  • Metabolic Response Of Marine Microalgae From Different Latitudes Towards Temperature Stress, Principal Investigator(PI), 2016 - 2019, Fundamental Research Grant Scheme (FRGS), (National)
  • Synthesis Of Titanocenedi(aminoacid) Salts For Evaluation Of Antitumor Activity, Consultant, 2015 - 2019, Fundamental Research Grant Scheme (FRGS), (National)
  • Alkaloid Variation In Malaysian Alstonia: Determination Of Variation Of Alkaloid Composition In A. Macrophylla As A Function Of Location, Consultant, 2015 - 2018, Fundamental Research Grant Scheme (FRGS), (National)
  • Enhancement Of Astaxanthin (pigment) Production In Microalgae Chlorococcum, Principal Investigator(PI), 2013 - 2016, Geran Penyelidikan Universiti Malaya (UMRG Programme) - SUS (Sustainability Science), (University)
  • In Vitro Antitumour Properties Of Leptospermum Flavescens And Baeckea Frutescens, Consultant, 2013 - 2015, Geran Penyelidikan Universiti Malaya (UMRG) - AFR (Frontier Science), (University)
  • In Vitro Antitumour Properties Of Leptospermum Flavescens And Baeckea Frutescens, Principal Investigator(PI), 2013 - 2015, Geran Penyelidikan Universiti Malaya (UMRG) - AFR (Frontier Science), (University)

(Name of Award), (Awarding Institution), (Year Awarded), (Level).

  • Certificate of Excellent Service, University Malaya, 2016, (University)
  • Science and Technology Research Grant, Toray Science Foundation Japan, 2011, (International)

(Contribution To Society), (Level), (Start Date), (End Date).

  • Organizing Committee member of The 8th Asian-Pacific Phycological Forum 2017 (APPF 2017), 8-13 October, 2017, (International), 24/01/2017 until 31/10/2017
  • Mentor of Buddhist Society University of Malaya (Persatuan Buddhis Universiti Malaya), (University), 25/04/2016 until 31/12/2018
  • Judge of Poster Presentation in International Congress of the Malaysian Society for Microbiology 2015 (7-10 December 2015), (International), 07/12/2015 until 10/12/2015
  • Scientific Committee of Algae Training Workshop 2015, (National), 11/11/2015 until 13/11/2015
  • Secretariat Committee of International Congress of The Malaysian Society for Microbiology 2015, (International), 01/06/2015 until 10/12/2015
  • Organizing committee for 'Responsible Conduct of Research: Ethical Practices and Integrity in Authorship', 27-28 March 2014, University of Malaya, (University), 27/03/2014 until 28/03/2014
  • Assistant treasurer of '2nd Conference for Regional Cooperation in Ocean and Earth Science Research in the South China Sea', 21-24 October 2012, University of Malaya, Kuala Lumpur., (International), 01/10/2011 until 24/10/2012


(Name of Degree), (Name of Candidates), (Title of Thesis), (Academic Session)

  • Master Degree, Brenda Leecyous, CD63 Expression on Basophils in Patients with Allergy to Beta-lactam Antibiotics, 2015/2016
  • Doctoral Degree (phd), Yong Wai Kuan, Interactive Effects of Temperature and Metal Toxicity on Microalgae, 2015/2016
  • Master Degree, Hazwani Mat Saad, Anti-melanogenesis and Anti-inflammatory Activities of Selected Medical and Culinary Mushrooms, 2015/2016
  • Doctoral Degree (phd), Yong Mei Mun, Chemical Constituents and Bioactivity of Selected Malaysian Plants, 2013/2014
  • Master Degree, Santhana Mary A/p Sandanam Raj, Antibacterial and Antioxidant Properties of Natural Colorants Derived from Selected Plants, 2013/2014
  • Master Degree, Hemapriyaa A/p Vijayan, Anti-skin Bacterial Activity of Selected Plant Extracts, 2013/2014
  • Doctoral Degree (phd), Suerialoasan A/l Navanesan, Cytotoxic Evaluation of Leptospermum javanicum and Baeckea frutescens Along with the Anti-cancer Activities of the Active Isolate, Betulinic Acid, 2012/2013
  • Master Degree, Kenneth Lau E-ming, Phenolic Content, Antioxidant Effect and Cytotoxic Activity of Selected Malaysian Seaweeds, 2012/2013
  • Doctoral Degree (phd), Saravana Kumar A/l Sinniah, Cytotoxic Activities, Apoptotic Induction and Mitochondrial Studies of Cationic Schiff Bases from The Thiosemicarbazone Family, 2011/2012
  • Master Degree, Annushuya A/p Subba Reddy, Cytotoxic Activity and Chemical Investigations of Alpinia scabra (blume) Naves, 2011/2012
  • Doctoral Degree (phd), Elcy Goh Pik Seah, Studies on Encapsulation of Tocotrienol-Rich Fraction of Palm Oil in Nanoemulsion using High-Energy Emulsification, 2011/2012
  • Doctoral Degree (phd), Teoh Wuen Yew, Bioactivities of Gynura Spp. and Phytochemical Investigations of Gynura bicolor, 2011/2012

  • Doctoral Degree (phd), Hazwani Binti Mat Saad, Chemical Investigations of Artocarpus Species and Their Potential In Cosmeceutical Applications, 2018/2019
  • Master Degree, S Savina A/p Savir, Synthesis, Cytotoxicity and Antimalarial activities of Metal Complexes of Thiosemicarbazones, 2018/2019
  • Doctoral Degree (phd), Tan Chun Hoe, In vitro anticancer properties and biological evaluation of alkaloids from selected Tabernaemontana species, 2018/2019
  • Doctoral Degree (phd), Heng Mok Piew, Syntheses and Biological Properties of Nickel(Ii) and Zinc (Ii) Complexes with Testosterone N(4)-substituted Thiosemicarbazone, 2016/2017