Curriculum Vitae

DR. LIM SIEW HUAH

Senior Lecturer
  • Department of Chemistry
    Faculty of Science
  • shlim80
  • +603-79674048

AREAS OF EXPERTISE

  • BIOORGANIC CHEMISTRY
    Physical Sciences, Chemistry, Organic Chemistry
  • NATURAL PRODUCTS CHEMISTRY (INCLUDING DRUG INTERMEDIATES FROM INDIGENOUS SOURCES)
    Physical Sciences, Chemistry, Organic Chemistry
  • CHEMICAL ANALYTICAL SPECTROMETRY
    Physical Sciences, Chemistry, Analytical Chemistry
  • CHEMICAL AND PHYSICAL METHODS
    Physical Sciences, Chemistry, Analytical Chemistry
  • CHARACTERISATION OF MOLECULES (INCLUDING BIOLOGICALLY ACTIVE MOLECULES)
    Physical Sciences, Chemistry, Macromolecular And Materials Chemistry
  • BIOACTIVE AND PHENOLIC COMPOUND
    Life Sciences, Phytochemicals, Nutraceuticals And Cosmetics, Nutraceuticals And Cosmetics

ACADEMIC QUALIFICATION

  • Doctoral Degree (PhD), (Bioorganic Chemistry)
    Universiti Malaya (UM)
  • MASTER DEGREE, (Organic Chemistry)
    Universiti Malaya (UM)
  • BSC, (Chemistry)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • AJK Kurikulum Program Sarjana Sains Kimia Analisis dan Analisis Beralatan
    30 Jan 2015 - present (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Kurikulum Program Sarjana Sains Kimia Analisis dan Analisis Beralatan
    30 Jan 2015 - present (Department of Chemistry, Faculty of Science)
  • Committee Members
    17 Sep 2024 - 16 Sep 2025 (Department)
  • Committee Members
    17 Sep 2024 - 16 Sep 2025 (Department)
  • Committee Members
    20 Sep 2023 - 19 Sep 2024 (Department of Chemistry, Faculty of Science)
  • Programme Coordinator
    05 Sep 2023 - 04 Sep 2024 (Department of Chemistry, Faculty of Science)
  • Committee Members
    10 Jun 2024 - 12 Jul 2024 (University Malaya)
  • Committee Members
    19 Feb 2024 - 24 May 2024 (Department)
  • Programme Coordinator
    20 Sep 2022 - 19 Sep 2023 (Department of Chemistry, Faculty of Science)
  • Committee Members
    02 Jun 2022 - 02 Jun 2023 (Department)
  • Committee Members
    02 Jun 2022 - 02 Jun 2023 (Department)
  • Committee Members
    02 Jun 2022 - 01 Jun 2023 (Department)
  • Task Force Member
    02 Jun 2022 - 01 Jun 2023 (Department)
  • Task Force Member
    02 Jun 2022 - 01 Jun 2023 (Department)
  • Task Force Member
    02 Jun 2022 - 01 Jun 2023 (Department)
  • Committee Members
    02 Jun 2022 - 01 Jun 2023 (Department)
  • Task Force Member
    17 Mar 2022 - 16 Mar 2023 (Department of Chemistry, Faculty of Science)
  • Task Force Leader
    07 Apr 2022 - 31 Dec 2022 (Department)
  • Programme Coordinator
    09 Sep 2021 - 08 Sep 2022 (Department of Chemistry, Faculty of Science)
  • PANEL PENASIHAT AKADEMIK, FAKULTI SAINS SESI AKADEMIK 2021/2022
    08 Sep 2021 - 07 Sep 2022 (Department of Chemistry, Faculty of Science)
  • PENYELARAS RAYUAN FAKULTI SAINS SESI AKADEMIK 2021/2022
    07 Sep 2021 - 06 Sep 2022 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Panyaringan Kertas Soalan Peperiksaan 2020/2021
    26 Nov 2020 - 25 Nov 2021 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Kurikulum
    06 Aug 2020 - 30 Sep 2021 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Alumni
    09 Sep 2020 - 08 Sep 2021 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Infotainment
    09 Sep 2020 - 08 Sep 2021 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Aktiviti Pelajar
    09 Sep 2020 - 08 Sep 2021 (Department of Chemistry, Faculty of Science)
  • Safety committee in Chemistry Department
    09 Sep 2020 - 08 Sep 2021 (Department of Chemistry, Faculty of Science)
  • Academic advisor
    28 Aug 2018 - 21 Aug 2021 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Jadual Waktu, Kuliah dan Peperiksaan sesi 2020/2021
    09 Sep 2020 - 28 Feb 2021 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Jadual Waktu, Kuliah dan Peperiksaan sesi 2019/2020
    01 Sep 2019 - 01 Sep 2020 (Department of Chemistry, Faculty of Science)
  • Safety committee in Chemistry Department
    01 Sep 2019 - 31 Aug 2020 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Penyediaan untuk Bahan Virtual Lab
    03 Aug 2020 - 28 Aug 2020 (Department of Chemistry, Faculty of Science)
  • Student Activity Task Force
    10 Jun 2019 - 10 Jun 2020 (Department of Chemistry, Faculty of Science)
  • Infotainment Task Force
    10 Jun 2019 - 09 Jun 2020 (Department of Chemistry, Faculty of Science)
  • TASK Force Penyediaan Dokumen PSAR 03 (MSc) 2019 - committee member
    17 May 2019 - 16 May 2020 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Semakan Kurikulum Program Sarjana Sains Kimia Analisis Beralatan
    21 Jan 2020 - 31 Mar 2020 (Department of Chemistry, Faculty of Science)
  • Committee member for Undergraduate Student's Poster Competition (Ijazah Dasar)
    07 Sep 2017 - 06 Sep 2019 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Jadual Waktu, Kuliah dan Peperiksaan sesi 2017/2018
    07 Sep 2017 - 06 Sep 2019 (Department of Chemistry, Faculty of Science)
  • Safety committee in Chemistry Department
    06 Sep 2017 - 06 Sep 2019 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Jadual Waktu, Kuliah dan Peperiksaan sesi 2018/2019 dan 2019/2020
    04 May 2018 - 04 May 2019 (Department of Chemistry, Faculty of Science)
  • Ahli JawatanKuasa bagi International Malaysian French Scientific Conference 2017 (IFMSC 2017)
    02 Oct 2017 - 21 Dec 2017 (Department of Chemistry, Faculty of Science)
  • Safety committee in Chemistry Department
    26 Oct 2016 - 25 Oct 2017 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Jadual Waktu, Kuliah dan Peperiksaan sesi 2016/2017
    14 Oct 2016 - 13 Oct 2017 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Kurikulum Program Sarjana Sains Kimia Analisis dan Analisis Beralatan
    19 Jan 2016 - 18 Jan 2017 (Department of Chemistry, Faculty of Science)
  • Safety committee in Chemistry Department
    14 Sep 2015 - 13 Sep 2016 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Jadual Waktu, Kuliah dan Peperiksaan sesi 2015/2016
    14 Sep 2015 - 13 Sep 2016 (Department of Chemistry, Faculty of Science)
  • Coordinator for Centralized Equipment System (CENFAC)
    08 Nov 2013 - 31 Dec 2015 (Department of Chemistry, Faculty of Science)
  • Committee member for Undergraduate Student's Yearly Activity Committee (Ijazah Dasar)
    14 Sep 2015 - 13 Sep 2015 (Department of Chemistry, Faculty of Science)
  • Ahli Jawatankuasa Jadual Waktu, Kuliah dan Peperiksaan sesi 2014/2015
    01 Sep 2014 - 31 Aug 2015 (Department of Chemistry, Faculty of Science)
  • Safety committee in Chemistry Department, Faculty Of Science
    08 Nov 2013 - 31 Aug 2015 (Department of Chemistry, Faculty of Science)
  • Committee member for Undergraduate Student's Yearly Activity Committee (Ijazah Dasar)
    08 Nov 2013 - 07 Nov 2014 (Department of Chemistry, Faculty of Science)

MEMBERSHIPS

  • MEMBER OF AMERICAN CHEMICAL SOCIETY (ACS), USA, MEMBER
    2025 to 2025 (International)
  • MEMBER OF THE ROYAL SOCIETY OF CHEMISTRY UK (MRSC), MEMBER
    2025 to 2025 (International)
  • AMERICAN CHEMICAL SOCIETY (ACS), MEMBER
    2024 to 2024 (International)
  • ROYAL SOCIETY OF CHEMISTRY (RSC), MEMBER
    2024 to 2024 (International)
  • AMERICAN CHEMICAL SOCIETY, MEMBER
    2023 to 2023 (International)
  • ROYAL SOCIETY OF CHEMISTRY, MEMBER
    2023 to 2023 (International)
  • ROYAL SOCIETY OF CHEMISTRY, MEMBER
    2022 to 2022 (International)
  • AMERICAN CHEMICAL SOCIETY, MEMBER
    2022 to 2022 (International)
  • PENYELARAS PROGRAM SARJANA MUDA SAINS KIMIA (KOHORT 2021/2022) SESI AKADEMIK 2021/2022, COMMITTEE MEMBER
    2021 to 2022 (University)
  • PANEL PENASIHAT AKADEMIK, FAKULTI SAINS SESI AKADEMIK 2021/2022, ADVISORY BOARD
    2021 to 2022 (University)
  • PENYELARAS RAYUAN FAKULTI SAINS SESI AKADEMIK 2021/2022, COMMITTEE MEMBER
    2021 to 2022 (University)
  • AMERICAN CHEMICAL SOCIETY, MEMBER
    2021 to 2021 (International)
  • ROYAL SOCIETY OF CHEMISTRY, MEMBER
    2021 to 2021 (International)
  • ROYAL SOCIETY OF CHEMISTRY, MEMBERS (MRSC)
    2020 to 2020 (International)
  • ROYAL SOCIETY OF CHEMISTRY, MEMBERSHIP
    2019 to 2019 (International)
  • THE ROYAL SOCIETY OF CHEMISTRY, MEMBER
    2014 to 2018 (International)

AWARD AND STEWARDSHIP

  • Khidmat Setia 20 Award
    2024, Universiti Malaya
  • Excellence Service Award
    2023, Universiti Malaya
  • Excellence Service Award
    2020, Universiti Malaya

PUBLICATIONS

Article in Journal
WoS
  1. Tan, Chun Hoe; Lim, Siew Huah; Sim, Kae Shin (2026). Computational Elucidation of Hub Genes and Pathways Correlated with the Development of 5-Fluorouracil Resistance in HCT 116 Colorectal Carcinoma Cell Line, BIOCHEMICAL GENETICS. . doi:10.1007/s10528-025-11041-2
  2. Al-Shaqsi, Noura; Khan, Faizullah; Al-Jahdhami, Habib; Ullah, Saeed; Khan, Ajmal; Ullah, Atta; Mohamad, Sharifah; Lim, Siew-Huah; Al-Harrasi, Ahmed; Rehman, Najeeb Ur (2025). Phytochemical Profiling, Biological Activities, and Molecular Docking Studies of Essential Oils from Ziziphus leucodermis (Baker) O. Schwartz, CHEMISTRY & BIODIVERSITY. . doi:10.1002/cbdv.202500434
  3. Funmi, Adebayo Zainab; Lim, Ching Yi; Ng, Min Phin; Toh, Wen Xin; Tan, Yee Seng; Sim, Kae Shin; Lim, Siew Huah; Tan, Chun Hoe; Ramle, Abdul Qaiyum (2025). Investigation of cytotoxic indoleninyl-thiobarbiturate zwitterions as DNA targeting agents, JOURNAL OF MOLECULAR STRUCTURE. 1322. doi:10.1016/j.molstruc.2024.140278
  4. Lim, Jing Xian; Yong, Phaik Har; Lim, Siew Huah; Ng, Zhi Xiang (2025). In vitro anti-neovascularization and anti-angiogenic activities of Platycladus orientalis (L.) Franco in human retinal endothelial cells via Raf/MEK 1/2 and AKT1/mTOR signaling, LIFE SCIENCES. 382. doi:10.1016/j.lfs.2025.124017
  5. Phang, Michael Weng Lok; Hisam, Nur Shahirah Mohd; Supandi, Farahaniza; Cheng, Poh Guat; Lim, Siew Huah; Lim, Lee Wei; Wong, Kah Hui (2025). The Tiger Milk Medicinal Mushroom Lignosus rhinocerus (Agaricomycetes) Mitigates Oxidative Damage in a Cellular Model Mimicking Friedreich's Ataxia, INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS. 27(11), 63-87
  6. Toh, Wen Xin; Tang, Sin Yee; Sim, Kae Shin; Lim, Siew Huah; Tan, Chun Hoe (2025). Ethnobotanical and alkaloid composition with their cytotoxicity of Tabernaemontana polyneura: A review with in silico ADMET analysis (vol 186, 106851, 2025), FITOTERAPIA. 187. doi:10.1016/j.fitote.2025.106869
  7. Toh, Wen Xin; Tang, Sin Yee; Sim, Kae Shin; Lim, Siew Huah; Tan, Chun Hoe (2025). Ethnobotanical and alkaloid composition with their cytotoxicity of Tabernaemontana polyneura: A review with in silico ADMET analysis, FITOTERAPIA. 186. doi:10.1016/j.fitote.2025.106851
  8. Ho, Keat Lam; Yong, Phaik Har; Lim, Siew Huah; Ng, Zhi Xiang (2024). Peperomia pellucida (L.) Kunth suppresses glycation-induced inflammatory response in human retinal pigment epithelial cell line ARPE-19 via JAK-STAT3 signaling, ARCHIV DER PHARMAZIE. . doi:10.1002/ardp.202400299
  9. Ho, Keat Lam; Yong, Phaik Har; Wang, Chee Woon; Lim, Siew Huah; Kuppusamy, Umah Rani; Arumugam, Bavani; Ngo, Chek Tung; Ng, Zhi Xiang (2024). In vitro anti-inflammatory activity and molecular docking of Peperomia pellucida (L.) Kunth extract via the NF- B and PPAR- signalling in human retinal pigment epithelial cells, BIOORGANIC CHEMISTRY. 153. doi:10.1016/j.bioorg.2024.107969
  10. Lim, Kuan-Hon; Mai, Chun-Wai; Wong, Soon -Kit; Low, Yun-Yee; Lim, Siew-Huah; Krishnan, Premanand (2024). Yunnanensine type indole and seco stemmadenine-yunnanensine type bisindole alkaloids from the bark of Alstonia scholaris, PHYTOCHEMISTRY LETTERS. 61, 97-103. doi:10.1016/j.phytol.2024.04.003
  11. Nyiew, Ke-Ying; Wong, Kah-Hui; Lim, Lee-Wei; Lim, Siew-Huah; Phang, Siew-Moi; Shyamala, Ratnayeke; Yow, Yoon-Yen (2024). Safety profile of subacute oral administration of ethanolic extract of Gracilaria manilaensis Yamamoto & Trono, JOURNAL OF APPLIED PHYCOLOGY. . doi:10.1007/s10811-024-03218-w
  12. Ong, Kang Kit; Ramle, Abdul Qaiyum; Ng, Min Phin; Lim, Siew Huah; Sim, Kae Shin; Tan, Chun Hoe (2024). Computational and In vitro Elucidation of Indolenine-barbituric Acid Zwitterions as Potential Chemotherapeutical Agents, LETTERS IN DRUG DESIGN & DISCOVERY. . doi:10.2174/0115701808279494231206060106
  13. Tan, Yi-Sheng; Ng, Min-Phin; Tan, Chun-Hoe; Tang, Wai-Kit; Sim, Kae-Shin; Yong, Kien-Thai; Krishnan, Premanand; Lim, Kuan-Hon; Lim, Siew-Huah; Low, Yun-Yee (2024). Quinoline, Indole, and Isogranatanine Alkaloids from Malayan Leuconotis eugeniifolia, JOURNAL OF NATURAL PRODUCTS. 87(2), 286-296. doi:10.1021/acs.jnatprod.3c00960
  14. Lew, Sze Yuen; Hisam, Nur Shahirah Mohd; Phang, Michael Weng Lok; Rahman, Syarifah Nur Syed Abdul; Poh, Rozaida Yuen Ying; Lim, Siew Huah; Kamaruzzaman, Mohd Amir; Chau, Sze Chun; Tsui, Ka Chun; Lim, Lee Wei; Wong, Kah Hui (2023). Adenosine Improves Mitochondrial Function and Biogenesis in Friedreich's Ataxia Fibroblasts Following L-Buthionine Sulfoximine-Induced Oxidative Stress, BIOLOGY-BASEL. 12(4). doi:10.3390/biology12040559
  15. Low, Yun-Yee; Lim, Siew-Huah (2023). Synthesis and crystal structure of dimethyl 2,2'-(2,5-bis(4-hydroxyphenyl)-2,5-dihydrofuran-3,4-diyl)dibenzoate, C34H30O7, ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES. 238(1), 91-93. doi:10.1515/ncrs-2022-0469
  16. Saad, Hazwani Mat; Tan, Chun Hoe; Manickam, Sugumaran; Lim, Siew Huah; Sim, Kae Shin (2023). Artocarpus heterophyllus Lam. Stem Bark Inhibits Melanogenesis through Regulation of ROS, cAMP, and MAPK Pathways, SAINS MALAYSIANA. 52(2), 441-465. doi:10.17576/jsm-2023-5202-10
  17. Subermaniam, Kogilavani; Lew, Sze Yuen; Yow, Yoon Yen; Lim, Siew Huah; Yu, Wing Shan; Lim, Lee Wei; Wong, Kah Hui (2023). Malaysian brown macroalga Padina australis mitigates lipopolysaccharide-stimulated neuroinflammation in BV2 microglial cells, IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES. 26(6), 669-679. doi:10.22038/IJBMS.2023.67835.14842
  18. Tan, Yi-Sheng; Wong, Soon-Kit; Yong, Kien-Thai; Lim, Kuan-Hon; Lim, Siew-Huah; Low, Yun-Yee (2023). Eugeniifoline, a Pentacyclic Indole Alkaloid from Leuconotis eugeniifolia, and Configurational Revision of Synthetic Eugeniifoline Isolated from a Diversity-Enhanced Extract, JOURNAL OF NATURAL PRODUCTS. . doi:10.1021/acs.jnatprod.2c00731
  19. Tang, Sin-Yee; Ng, Min-Phin; Tan, Chun-Hoe; Sim, Kae-Shin; Lim, Kuan-Hon; Yong, Kien-Thai; Low, Yun-Yee; Lim, Siew-Huah (2023). Chippiine, iboga, cleavamine, vobasine, and cytotoxic bisindole alkaloids from Tabernaemontana polyneura, TETRAHEDRON. 149. doi:10.1016/j.tet.2023.133706
  20. Tang, Sin-Yee; Tan, Chun-Hoe; Sim, Kae-Shin; Yong, Kien-Thai; Lim, Kuan-Hon; Low, Yun-Yee; Lim, Siew-Huah (2023). Polyneurines A-H, iboga alkaloids from Tabernaemontana polyneura, PHYTOCHEMISTRY. 208. doi:10.1016/j.phytochem.2023.113587
  21. Ho, Keat Lam; Ng, Zhi Xiang; Wang, Chee Woon; Junit, Sarni Mat; Lim, Siew Huah; Ngo, Chek Tung; Yong, Audrey Chee Hui; Yong, Phaik Har (2022). Comparative Analysis of In Vitro Enzyme Inhibitory Activities and Phytochemicals from Platycladus orientalis (L.) Franco via Solvent Partitioning Method, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY. . doi:10.1007/s12010-022-03921-9
  22. Ho, Keat Lam; Tan, Chung Ghuan; Yong, Phaik Har; Wang, Chee Woon; Lim, Siew Huah; Kuppusamy, Umah Rani; Ngo, Chek Tung; Massawe, Festo; Ng, Zhi Xiang (2022). Extraction of phytochemicals with health benefit from Peperomia pellucida (L.) Kunth through liquid-liquid partitioning, JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS. 30. doi:10.1016/j.jarmap.2022.100392
  23. Lai, Nicole Jean-Yean; Ngu, Ee-Ling; Pang, Jun-Rui; Wong, Kah-Hui; Ardianto, Chrismawan; Ming, Long Chiau; Lim, Siew-Huah; Walvekar, Shweta Gangasa; Anwar, Ayaz; Yow, Yoon-Yen (2022). Carrageenophyte Kappaphycus malesianus Inhibits Microglia-Mediated Neuroinflammation via Suppression of AKT/NF-kappa B and ERK Signaling Pathways, MARINE DRUGS. 20(8). doi:10.3390/md20080534
  24. Ngu, Ee-Ling; Tan, Cheng-Yau; Lai, Nicole Jean-Yean; Wong, Kah-Hui; Lim, Siew-Huah; Ming, Long Chiau; Tan, Kuan-Onn; Phang, Siew-Moi; Yow, Yoon-Yen (2022). Spirulina platensis Suppressed iNOS and Proinflammatory Cytokines in Lipopolysaccharide-Induced BV2 Microglia, METABOLITES. 12(11). doi:10.3390/metabo12111147
  25. Sim, Dawn Su -Yin; Tang, Sin-Yee; Low, Yun-Yee; Lim, Siew-Huah; Kam, Toh-Seok (2022). Vobasine, vincamine, voaphylline, tacaman, and iboga alkaloids from Tabernaemontana corymbosa, PHYTOCHEMISTRY. 203. doi:10.1016/j.phytochem.2022.113384
  26. Tan, Chun Hoe; Sim, Dawn Su Yin; Lim, Siew Huah; Mohidin, Taznim Begam Mohd; Mohan, Gokula; Low, Yun Yee; Kam, Toh Seok; Sim, Kae Shin (2022). Antiproliferative and Microtubule-stabilizing Activities of Two Iboga-vobasine Bisindoles Alkaloids from Tabernaemontana corymbosa in Colorectal Adenocarcinoma HT-29 Cells, PLANTA MEDICA. 88(14), 1325-1340. doi:10.1055/a-1755-5605
  27. Wong, Soon-Kit; Tan, Yi-Sheng; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok (2022). Arboduridine, a hexacyclic caged monoterpenoid indole incorporating cyclohexane, piperidine, and bridged-fused pyrrolidine-tetrahydrofuran moieties, TETRAHEDRON LETTERS. 98. doi:10.1016/j.tetlet.2022.153836
  28. Lai, Nicole Jean Yean; Ngu, Ee Ling; Pang, Jun Rui; Wong, Kah Hui; Lim, Siew Huah; Yow, Yoon Yen (2021). UNRAVELLING THE ANTI-NEUROINFLAMMATORY ACTIVITY OF THE MALAYSIAN RED MACROALGA KAPPAPHYCUS MALESIANUS IN LIPOPOLYSACCHARIDES-STIMULATED BV2 MICROGLIA, PHYCOLOGIA. 60, 128-129
  29. Pang, Jun-Rui; Lim, Siew-Huah; Wong, Kah-Hui; Yow, Yoon-Yen (2021). GRACILARIA MANILAENSIS YAMAMOTO & TRONO EXTRACTS IN ATTENUATION OF LIPOPOLYSACCHARIDE-STIMULATED NEUROINFLAMMATION IN BV2 MICROGLIA, PHYCOLOGIA. 60, 130-130
  30. Saad, H. M., Tan, C. H., Lim, S. H., Manickam, S., & Sim, K. S. (2021). Evaluation of anti-melanogenesis and free radical scavenging activities of five Artocarpus species for cosmeceutical applications. Industrial Crops and Products, 161, 10. doi: 10.1016/j.indcrop.2020.113184
  31. Tan, C. H., Yeap, J. S. Y., Lim, S. H., Low, Y. Y., Sim, K. S., & Kam, T. S. (2021). The Bisindole Alkaloids Angustilongines M and A from Alstonia penangiana Induce Mitochondrial Apoptosis and G0/G1 Cell Cycle Arrest in HT-29 Cells through Promotion of Tubulin Polymerization. Journal of natural products, 84(5), 1524-1533. doi: 10.1021/acs.jnatprod.1c00013
  32. Wong, S. K., Yeap, J. S. Y., Tan, C. H., Sim, K. S., Lim, S. H., Low, Y. Y., & Kam, T. S. (2021). Arbolodinines A-C, biologically-active aspidofractinine-aspidofractinine, aspidofractinine-strychnan, and kopsine-strychnan bisindole alkaloids from Kopsia arborea. Tetrahedron, 78, 9. doi: 10.1016/j.tet.2020.131802
  33. Yow, Y. Y., Goh, T. K., Nyiew, K. Y., Lim, L. W., Phang, S. M., Lim, S. H., . . . Wong, K. H. (2021). Therapeutic Potential of Complementary and Alternative Medicines in Peripheral Nerve Regeneration: A Systematic Review. Cells, 10(9), 35. doi: 10.3390/cells10092194
  34. Lew, S. Y., Lim, S. H., Lim, L. W., & Wong, K. H. (2020). Neuroprotective effects of Hericium erinaceus (Bull.: Fr.) Pers. against high-dose corticosterone-induced oxidative stress in PC-12 cells. Bmc Complementary Medicine and Therapies, 20(1), 16. doi: 10.1186/s12906-020-03132-x
  35. Lew, S. Y., Teoh, S. L., Lim, S. H., Lim, L. W., & Wong, K. H. (2020). Discovering the Potentials of Medicinal Mushrooms in Combating Depression - A Review. Mini-Reviews in Medicinal Chemistry, 20(15), 1518-1531. doi: 10.2174/1389557520666200526125534
  36. Loh, Sze Le; Sobolev, Alexandre N.; Lim, Siew Huah; Ling, Irene (2020). Influence of ortho- and meta-substituted N-heterocyclic dications towards the self-assembly of p-sulfonatocalix[4]arene, CRYSTENGCOMM. 22(1), 52-60. doi:10.1039/c9ce01410a
  37. Subermaniam, K., Yow, Y. Y., Lim, S. H., Koh, O. H., & Wong, K. H. (2020). Malaysian macroalga Padina australis Hauck attenuates high dose corticosterone-mediated oxidative damage in PC12 cells mimicking the effects of depression. Saudi Journal of Biological Sciences, 27(6), 1435-1445. doi: 10.1016/j.sjbs.2020.04.042
  38. Subermaniam, Kogilavani; Yow, Yoon Yen; Lim, Siew Huah; Koh, Ong Hui; Wong, Kah Hui (2020). Malaysian macroalga Padina australis Hauck attenuates high dose corticosterone-mediated oxidative damage in PC12 cells mimicking the effects of depression, SAUDI JOURNAL OF BIOLOGICAL SCIENCES. 27(6), 1435-1445. doi:10.1016/j.sjbs.2020.04.042
  39. Tan, C. H., Sim, D. S. Y., Heng, M. P., Lim, S. H., Low, Y. Y., Kam, T. S., & Sim, K. S. (2020). Evaluation of DNA Binding and Topoisomerase I Inhibitory Activities of 16 '-Decarbomethoxydihydrovoacamine from Tabernaemontana corymbosa. ChemistrySelect, 5(47), 14839-14843. doi: 10.1002/slct.202004153
  40. Yeap, J. S. Y., Tan, C. H., Yong, K. T., Lim, K. H., Lim, S. H., Low, Y. Y., & Kam, T. S. (2020). Macroline, talpinine, and sarpagine alkaloids from Alstonia penangiana. An NMR-based method for differentiating between A. penangiana and A. macrophylla. Phytochemistry, 176, 12. doi: 10.1016/j.phytochem.2020.112391
  41. Sim, D. S. Y., Navanesan, S., Sim, K. S., Gurusamy, S., Lim, S. H., Low, Y. Y., Kam, T. S. (2019). Conolodinines A-D, Aspidosperma-Aspidosperma Bisindole Alkaloids with Antiproliferative Activity from Tabernaemontana corymbosa. Journal of Natural Products, 82(4), 850-858. doi:10.1021/acs.jnatprod.8b00919
  42. Sim, Dawn Su-Yin; Navanesan, Suerialoasan; Sim, Kae-Shin; Gurusamy, Subramaniam; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok (2019). Conolodinines A-D, Aspidosperma-Aspidosperma Bisindole Alkaloids with Antiproliferative Activity from Tabernaemontana corymbosa, JOURNAL OF NATURAL PRODUCTS. 82(4), 850-858. doi:10.1021/acs.jnatprod.8b00919
  43. Wong, S. K., Wong, S. P., Sim, K. S., Lim, S. H., Low, Y. Y., Kam, T. S. (2019). A Cytotoxic Indole Characterized by Incorporation of a Unique Carbon-Nitrogen Skeleton and Two Pentacyclic Corynanthean Alkaloids Incorporating a Substituted Tetrahydrofuranone Ring from Kopsia arborea. Journal of Natural Products, 82(7), 1902-1907. doi:10.1021/acs.jnatprod.9b00255
  44. Wong, Soon-Kit; Wong, Suet-Pick; Sim, Kae-Shin; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok (2019). A Cytotoxic Indole Characterized by Incorporation of a Unique Carbon-Nitrogen Skeleton and Two Pentacyclic Corynanthean Alkaloids Incorporating a Substituted Tetrahydrofuranone Ring from Kopsia arborea, JOURNAL OF NATURAL PRODUCTS. 82(7), 1902-1907. doi:10.1021/acs.jnatprod.9b00255
  45. Yeap, J. S. Y., Lim, K. H., Yong, K. T., Lim, S. H., Kam, T. S., Low, Y. Y. (2019). Lycopodium Alkaloids: Lycoplatyrine A, an Unusual Lycodine-Piperidine Adduct from Lycopodium platyrhizoma and the Absolute Configurations of Lycoplanine D and Lycogladine H. Journal of Natural Products, 82(2), 324-329. doi:10.1021/acs.jnatprod.8b00754
  46. Yeap, J. S. Y., Saad, H. M., Tan, C. H., Sim, K. S., Lim, S. H., Low, Y. Y., Kam, T. S. (2019). Macroline-Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana. Journal of Natural Products, 82(11), 3121-3132. doi:10.1021/acs.jnatprod.9b00712
  47. Yeap, Joanne Soon-Yee; Lim, Kuan-Hon; Yong, Kien-Thai; Lim, Siew-Huah; Kam, Toh-Seok; Low, Yun-Yee (2019). Lycopodium Alkaloids: Lycoplatyrine A, an Unusual Lycodine-Piperidine Adduct from Lycopodium platyrhizoma and the Absolute Configurations of Lycoplanine D and Lycogladine H, JOURNAL OF NATURAL PRODUCTS. 82(2), 324-329. doi:10.1021/acs.jnatprod.8b00754
  48. Yeap, Joanne Soon-Yee; Saad, Hazwani Mat; Tan, Chun-Hoe; Sim, Kae-Shin; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok (2019). Macroline-Sarpagine Bisindole Alkaloids with Antiproliferative Activity from Alstonia penangiana, JOURNAL OF NATURAL PRODUCTS. 82(11), 3121-3132. doi:10.1021/acs.jnatprod.9b00712
  49. Yeap, Joanne Soon-Yee; Navanesan, Suerialoasan; Sim, Kae-Shin; Yong, Kien-Thai; Gurusamy, Subramaniam; Lim, Siew-Huah; Low, Yun-Yee; Kam, Toh-Seok (2018). Ajmaline, Oxindole, and Cytotoxic Macroline-Akuammiline Bisindole Alkaloids from Alstonia penangiana, JOURNAL OF NATURAL PRODUCTS. 81(5), 1266-1277. doi:10.1021/acs.jnatprod.8b00170
  50. Lim, S. H., Low, Y. Y., Subramaniam, G., Abdullah, Z., Thomas, N. F., Kam, T. S. (2013). Lumusidines A-D and villalstonidine F, macroline-macroline and macroline-pleiocarpamine bisindole alkaloids from Alstonia macrophylla, Phytochemistry. 87, 148-156
Others
  1. Jun-Lee Lim, Kae Shin Sim, Kien-Thai Yong, Bi-Juin Loong, Kang-Nee Ting, Siew-Huah Lim, Yun-Yee Low, Toh-Seok Kam. 2015. Biologically active vallesamine, strychnan, and rhazinilam alkaloids from Alstonia: Pneumatophorine, a nor-secovallesamine with unusual incorporation of 3-ethylpyridine moiety. Phytochemistry, 2015, 117, 317-324
  2. Kuan-Hon Lim, Vijay J. Raja, Tracey Bradshaw, Siew- Huah Lim, Yun-Yee Low, Toh-Seok Kam, 2015. Ibogan, tacaman, and cytotoxic bisindole alkaloids from Tabernaemontana. Cononusine, an iboga alkaloid with unusual incorporation of a pyrrolidone moiety. J. Nat. Prod.
  3. Lim, S. H.; Tan, S. J.; Low, Y. Y.; Lim, K. H.; Thomas, N. F.; Kam, T. S. Perhentidines A-C: macroline-macroline bisindoles from Alstonia and the absolute configuration of perhentinine and macralstonine, J. Nat. Prod., 2012, 74, 942-950.
  4. Lim, S. H.; Tan, S. J.; Low, Y. Y.; Kam, T. S. Lumutinines A-D, linearly fused macroline-macroline and macroline-sapargine bisindole from Alstonia macrophylla, J. Nat. Prod., 2011, 74, 2556-2562
  5. Lim, S. H.; Mahmood, K.; Komiyama, K.; Kam, T. S. A cycloartane incorporating a fused tetrahydrofuran ring and a cytotoxic lactam from Monocarpia marginalis, J. Nat Prod., 2008, 71, 1104‒1106
  6. Lim, S. H.; Sim, K. M.; Abdullah, Z.; Hiraku, O.; Hayashi, M.; Komiyama, K.; Kam, T. S. Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia, J. Nat Prod., 2007, 70, 1380‒1383.

CONSULTANCY PROJECT

  • Eu Reach - Substance Identification Test (fatty Alcohols), Apical (Malaysia) Sdn. Bhd.
    06 Jan 2025 - 14 Feb 2025 (National)
  • Eu Reach - Substance Identification Test, Evyap Sabun Malaysia Sdn. Bhd. (944963M)
    04 Nov 2025 - 15 Dec 2025 (National)
  • Eu Reach - Substance Identification Test, Evyap Sabun Malaysia Sdn. Bhd. (944963M)
    07 Nov 2024 - 21 Nov 2024 (National)
  • Eu Reach - Substance Identification Test, Evyap Sabun Malaysia Sdn. Bhd. (944963M)
    11 Dec 2023 - 24 Dec 2023 (National)
  • Nmr Analysis of Fatty Acids from Palm Oil for Reach Certification, Apical (M) Sdn Bhd, Consultant
    01 Aug 2022 - 15 Sep 2022 (National)
  • Isolation of Active Secondary Metabolites from Actinomycetes, BioValence Sdn Bhd
    01 Dec 2016 - 01 Dec 2019 (National)
  • To Determine The Contents of Chemical Constituents and Trace Metals of Cordyceps Extracts., Z System Solution
    04 Apr 2016 - 01 Dec 2016 (National)

ACADEMIC/ PROF. SERVICES

Evaluation
  1. (2026) Appointment as Academic Programme Advisor for Diploma in Science Programme (tar UMT), National, (External Assessor)
  2. (2025) Synthesis and Characterization of Azo-bridged Benzothiazoles With Fatty Acids from Palm Oil as Flexible Alkyl Chain for Liquid Crystal Potentials, University, (Internal Examiner)
  3. (2024) Master of Philosophy Thesis (IAS, UM) by Layane Haitham Mohammed Hassan Elbehairy - Phytochemical Analysis and Anticandidal Activity in Vitro of Cleistanthus Bracteosus Jabl. (phyllanthaceae Martinov 1820) Endemic to The Primary Rainforest of Perak, Malaysia, University, (Internal Examiner)
  4. (2024) PhD Thesis by Fatin Nur Elyana Binti Mohd Sidek - Exploration of Fused Quinazoline Derivatives for Potential Epidermal Growth Factor Receptor Inhibition, University, (Internal Examiner)
  5. (2024) Candidature Defense by Ang Zhang Kai - Synthesis and Characterization of Azo-bridged Benzothiazole Compounds With Fatty Acids from Palm Oil as Flexible Alkyl Chain for Liquid Crystal Potentials, University, (Internal Assessor)
  6. (2024) Mosh/moah in Edible Vegetable Oil: a Comprehensive Summary, International, (Reviewer)
  7. (2024) PhD Thesis by Muhammad Afiq Ngadni - Chemical Constituents from The Fruits of Chisocheton Erythrocarpus Hiern and Development of Nano-emulsion as Larvicial Agent, University, (Internal Examiner)
  8. (2023) Examination of a PhD Thesis - Synthesis, Characterization and in Vitro Study of Pairs of Mono- and Dinuclear Copper(ii) and Zinc(ii) Complexes Against Plasmodium Falciparum, University, (Internal Examiner)
Contribution to external organisation
  1. (2025) Appointed Associate for The Acs Committee On Ethics, International, (Research Fellow/Associate)
Contribution to event
  1. (2024) PhD Thesis Seminar by Mr Tang Liang Wei - Simultaneous Quantification of Cadmium and Lead Ions Using Beta-cyclodextrin Functionalized Poly(amino Acid) Electrochemical Sensor, University, (Panelist/Moderator)
Media appearance
  1. (2024) Public Education On Safety Considerations When Selecting Scented Candles Was Provided by Me in a Segment On Living Delight, a Program Aired by 8tv, a Local Television Station, in December 2024. Insights Were Shared During The Segment, Which is Available At Https://youtu.be/vbj8buxvfd8?si=s5oa6zabpah9rbfp., National, (Interview)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2025) ALKALOIDS FROM THE GENUS LYCOPODIUM AND MELODINUS, BONG HUI CHEN
  2. (2025) SECONDARY METABOLITES (ALKALOIDS) FROM THE PANDANACEAE FAMILY, RINIISHA A/P MUNIANDY
  3. (2025) COMPUTATIONAL AND IN VITRO STUDIES OF INDOLE ALKALOIDS FROM TABERNAEMONTANA POLYNEURA AS POTENTIAL CHEMOTHERAPEUTICAL DRUGS, TOH WEN XIN
  4. (2025) Studying the effect of antioxidant extracted from the sprouts of some Omani seeds on the most communal types of women cancers in Oman, NOURA HAMED KHALIFA ALSHAQSI
  5. (2024) Structure and Biological Activity of Alkaloids from Leuconotis eugeniifolia, TAN YI SHENG
  6. (2023) Neuroregeneration Potential of Gracilaria manilaensis Yamamoto & Trono in the Treatment of Peripheral Nerve Injury, Nyiew Ke Yin (Sunway University)
  7. (2023) Chemical Investigations and Antiproliferative Activities of the Alkaloids from Tabernaemontana polyneura, TANG SIN YEE
  8. (2023) “Further Phytochemical and Cytotoxicity Studies of the Indole Alkaloids of kopsia arborea Stem-Bark”, WONG SOON KIT
  9. (2022) Preliminary title of research: Elucidation of the Modulatory Mechanism of Thuja Against Neurodegeneration and Neovascularization in Diabetic Retinopathy, Lim Jing Xian (University of Nottingham Malaysia Campus)
  10. (2022) Biochemical Investigations of Artocarpus Spp. for Cosmeceutical Applications, HAZWANI BINTI MAT SAAD
  11. (2022) Protective Mechanisms of Hericium Erinaceus (NevGro®) Against Oxidative Stress in In Vitro Models of Friedreich’s Ataxia and Depression, LEW SZE YUEN
  12. (2021) NEUROPROTECTIVE MECHANISMS OF BROWN MACROALGA PADINA AUSTRALIS IN THE MITIGATION OF OXIDATIVE DAMAGE AND NEUROINFLAMMATION IN DEPRESSION, KOGILAVANI A/P SUBERMANIAM
  13. (2021) IN VITRO ANTI-CANCER PROPERTIES OF BISINDOLE ALKALOIDS FROM Tabernaemontana corymbosa AND Alstonia penangiana AGAINST HUMAN COLON CANCER CELLS, TAN CHUN HOE
  14. (2020) Studies on the potential therapeutic role of Peperomia pellucida (L.) extract against high glucose-induced oxidative-glycative cellular damage, HO KEAT LAM (University of Nottingham Malaysia Campus)
  15. (2018) NEORITOGENIC AND NEUROPROTECTIVE ACTIVITY OF MALAYSIAN AGAROPHYTE: GRACILARIA MANILAENSIS YAMAMOTO & TRONO, PANG JUN RUI (Sunway University)
  16. (2017) BIOLOGICALLY ACTIVE ALKALOIDS FROM Tabernaemontana corymbosa, DAWN SIM SU-YIN
Master
  1. (2025) ANTI-MELANOGENESIS ACTIVITY OF VARIOUS BANANA PEELS EXTRACT IN DIFFERENT RIPENING STAGES, NG HUI SHAN
  2. (2019) Anti-neuroinflammatory Activity of Malaysian Carrageenophyte Kappaphycus Species, Nicole Lai Jean Yean (15024706) (Sunway University)
  3. (2018) Alkaloids from Kopsia arborea, Tung Chu Ling
  4. (2016) Search and selection of biologically active substances from the underground parts Eremostachys moluccelloides L, Alimkhan Maral
  5. (2015) Indole and Bisindoel alkaloids from Alstonia macrophylla, Siti Aishah Bt Ismail
  6. (2014) ALKALOIDS FROM ALSTONIA PNEUMATOPHORA AND ALSTONIA ROSTRATA, LIM JUN LEE

TEACHING

Master
  1. (2025) SQC7006 - Molecular Spectroscopic Analysis
  2. (2024) SQC7006 - Molecular Spectroscopic Analysis
  3. (2023) SQC7006 - Molecular Spectroscopic Analysis
  4. (2022) SQC7006 - Molecular Spectroscopic Analysis
  5. (2020) SQC7006 - Molecular Spectroscopic Analysis
  6. (2020) SQC7006 - Molecular Spectroscopic Analysis
  7. (2020) SQC7006 - Molecular Spectroscopic Analysis
  8. (2019) SQC7006 - Molecular Spectroscopic Analysis
  9. (2016) SCGS6317 - Molecular Spectroscopic Analysis - Ft-nmr, Ft-ir, Nir, Ft-raman
  10. (2016) SCGS6317 - Molecular Spectroscopic Analysis - Ft-nmr, Ft-ir, Nir, Ft-raman
  11. (2015) SCGS6317 - Molecular Spectroscopic Analysis - Ft-nmr, Ft-ir, Nir, Ft-raman
  12. (2014) SCGS6317 - Molecular Spectroscopic Analysis - Ft-nmr, Ft-ir, Nir, Ft-raman
Bachelor
  1. (2025) SIC1003 - Organic Chemistry I
  2. (2025) SIC1008 - Organic Chemistry I
  3. (2025) SIC2019 - Practical of Organic Chemistry Ii
  4. (2024) SIC1003 - Organic Chemistry I
  5. (2024) SIC1008 - Organic Chemistry I
  6. (2024) SIC2019 - Practical of Organic Chemistry Ii
  7. (2023) SIC1003 - Organic Chemistry I
  8. (2022) SIC1003 - Organic Chemistry I
  9. (2022) SIC1008 - Organic Chemistry I
  10. (2022) SIC1011 - Safety and Basic Laboratory Techniques
  11. (2022) SIC2007 - Spectroscopic Methods in Organic Chemistry
  12. (2022) SIC2024 - Spectroscopic Methods in Organic Chemistry
  13. (2021) SQC7006 - Molecular Spectroscopic Analysis
  14. (2021) SIC3009 - Natural Product Chemistry
  15. (2021) SIC2002 - Organic Chemistry Ii
  16. (2021) SIC2007 - Spectroscopic Methods in Organic Chemistry
  17. (2020) SIC3009 - Natural Product Chemistry
  18. (2020) SIC1003 - Organic Chemistry I
  19. (2020) SIC2007 - Spectroscopic Methods in Organic Chemistry
  20. (2020) SCES3324 - Natural Product Chemistry
  21. (2020) SIC1003 - Organic Chemistry I
  22. (2020) SIC1003 - Organic Chemistry I
  23. (2020) SIC1003 - Organic Chemistry I
  24. (2020) SIC2002 - Organic Chemistry Ii
  25. (2020) SIC2007 - Spectroscopic Methods in Organic Chemistry
  26. (2020) SIC3009 - Natural Product Chemistry
  27. (2019) Spectroscopic Methods in Organic Chemistry
  28. (2019) Ethics and Safety
  29. (2019) Natural Product Chemistry
  30. (2019) SIC1003 - Organic Chemistry I
  31. (2019) SIC1003 - Organic Chemistry I
  32. (2019) SIC2007 - Spectroscopic Methods in Organic Chemistry
  33. (2019) SIC3009 - Natural Product Chemistry
  34. (2019) SIC3009 - Natural Product Chemistry
  35. (2019) SIX1002 - Ethics and Safety
  36. (2019) SIX1002 - Ethics and Safety
  37. (2019) SIX1002 - Ethics and Safety
  38. (2018) Ethics and Safety
  39. (2018) SIC1003 - Organic Chemistry I
  40. (2018) SIC3009 - Natural Product Chemistry
  41. (2017) SCES2220 - Organic Chemistry Ii
  42. (2017) SCES2260 - Spectroscopic Methods in Organic Chemistry
  43. (2017) SCES2260 - Spectroscopic Methods in Organic Chemistry
  44. (2017) SCES2261 - Heterocyclic Chemistry
  45. (2017) SCES3324 - Natural Product Chemistry
  46. (2017) SIC2002 - Organic Chemistry
  47. (2017) SIC2007 - Spectroscopic Methods in Organic Chemistry
  48. (2017) SIC2007 - Spectroscopic Methods in Organic Chemistry
  49. (2017) SIC2010 - Heterocyclic Chemistry
  50. (2017) SIC2010 - Heterocyclic Chemistry
  51. (2016) SCES2261 - Heterocyclic Chemistry
  52. (2015) SCES2260 - Spectroscopic Methods in Organic Chemistry
  53. (2015) SCES2260 - Spectroscopic Methods in Organic Chemistry
  54. (2015) SCES2261 - Heterocyclic Chemistry
  55. (2014) SCES2246 - Functional Group Chemistry
  56. (2014) SCES2261 - Heterocyclic Chemistry
  57. (2013) SCES2246 - Functional Group Chemistry
  58. (2013) SCES3120 - Organic Chemistry III
Full-Time Equivalent (FTE)
  1. (2025) SIC1003 - Organic Chemistry I
  2. (2025) SIC1008 - Organic Chemistry I
  3. (2026) SIC1008 - Organic Chemistry I
  4. (2026) SIC2007 - Spectroscopic Methods in Organic Chemistry
  5. (2025) SIC2019 - Practical of Organic Chemistry Ii
  6. (2026) SIC2019 - Practical of Organic Chemistry Ii
  7. (2026) SIC2024 - Spectroscopic Methods in Organic Chemistry
  8. (2025) SQC7006 - Molecular Spectroscopic Analysis

SOCIAL RESPONSIBILITY ACTIVITIES

  • 1. Refurbished Hostel and Upgrade The Air Ventilation System in The Hall At Valley of Hope, Sungai Buluh 2. Hold a Musical Carnival to Promote The Place as Culture Heritage, (01 Sep 2019 - 05 Oct 2019)
  • Volunteer Trainer for Malaysian Contigent 51st International Chemistry Olympiad 2019 (icho2019), (01 Jul 2019 - 19 Jul 2019)