Curriculum Vitae

PROF. DR. SHIREENE RATNA A/P D B VETHAKKAN

Professor
  • Department of Medicine
    Faculty of Medicine

BIOGRAPHY

Associate Professor Shireene Ratna Vethakkan obtained her MBBS from the University of Malaya, and Masters of Internal Medicine from Universiti Kebangsaan Malaysia. She then underwent endocrine training at the University of Malaya Medical Centre and a fellowship in endocrinology at the Department of Endocrinology and Diabetes in St. Vincent's Hospital Melbourne. This was followed by an MD(Doctorate of Medicine-Research) at the University of Melbourne focusing on islet-function and insulin-sensitivity in patients with type 1 diabetes post-islet-transplantation. Her expertise lies in the subspecialty of diabetology, in particular human islet-transplantation, lipotoxicity and beta-cell function. She is skilled in the evaluation of beta-cell function/insulin sensitivity utilizing computer modelling and the IVGTT, and can also conduct clamp studies.

She was appointed Head of the Division of Endocrinology&Diabetes , Department of Medicine in 2012 and is currently holding that post. She holds several grants and has researched amongst other things: the link between lipemia/maternal BMI  and pregnancy outcomes, impact of ethnicity/culture on Vitamin D insufficiency/therapy in Malaysia, pituitary dysfunction in nasopharyngeal carcinoma survivors,  and pharmcogenomic aspects of obesity/diabetes.  Her most recent collaboration has been with the Malaysian Palm Oil Board/King's College Department of Nutrition, exploring the effect of dietary fat on pancreatic beta cell function and cardiovascular risk. She continues to be involved in research into the growing epidemic of non-alcoholic steatohepatitis in Malaysia. She is the principal investigator and leader of an ongoing cohort study( in collaboration with the obstetric and paediatric units of the University of Malaya Medical Centre) evaluating the impact of maternal metabolic dysfunction on offspring health and wellbeing. 

She has published papers in the Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Lipidology,Clinical Nutrition,Transplantation, Endocrine Practice, Diabetic Medicine and Journal of Diabetes Investigation. She has also supervised to completion many PhD, Masters of Science, Masters of Medicine and Endocrine Subspecialty Fellows. 

Dr. Vethakkan is also an experienced consultant endocrinologist and physician. In the coming year, she intends to expand/improve diabetes/endocrinology services in UMMC by instituting short refresher courses for interns, nurses and other allied health staff, as well as organizing national diabetes/insulin camps and public education seminars for patients as part of the unit's community services.

In the next 5 years, she hopes to complete her research into the relationship between lipotoxicity and b-cell function in Asian gestational diabetes. She will be developing an online algorithm for inpatient diabetes management as well as a handbook of endocrine testing protocols that will be accessible to all hospital staff.

Long-term, she would like to acquire the skills and expertise to research the relationship between epigenetics and beta-cell function and further develop insulin pump services in UMMC.

 

AREAS OF EXPERTISE

  • ENDOCRINOLOGY
    DOCTOR OF MEDICINE
  • ENDOCRINOLOGY
    Osteoporosis
  • ENDOCRINOLOGY
    human islet transplantation

ACADEMIC QUALIFICATION

  • MD(MELBOURNE)(2012), (Medicine)
    University of Melbourne, Australia
  • M.Med(Internal Medicine), (Penyakit Dalaman)
    Universiti Kebangsaan Malaysia (UKM)
  • MBBS(UM)(1994), (Medicine)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • Committee Member, National Endocrine Training Committee
    01 Jan 2014 - present (National)
  • Committee member, Organizing Committee for UMMC Primary Care Symposium
    24 Mar 2012 - present (Faculty)
  • Committee member, organizing committee for Program Pendidikan Diabetis untuk Staf PPUM
    11 Mar 2003 - present (Faculty)
  • Committee Member, Clinical Quality Assurance Committee
    30 Jan 2004 - present (Faculty)
  • Head of Endocrine Unit
    01 Jun 2012 - present (Faculty)
  • Ahli Mesyuarat Jawatankuasa Program Fellowship Sub-Kepakaran Bidang Endokrinologi, Kementerian Kesihatan Malaysia
    01 Jan 2013 - present (National)
  • Ahli Mesyuarat Jawatankuasa Program Fellowship Sub-Kepakaran Bidang Endokrinologi, Kementerian Kesihatan Malaysia
    01 Jan 2013 - present (National)
  • Department Coordinator for Problem-Based Learning Phase 3A 2011/2012
    01 Mar 2011 - present (Faculty)
  • Committee Members
    01 Jan 2018 - 31 Dec 2023 (Department)
  • Committee Members
    10 Apr 2017 - 31 Dec 2023 (Department)
  • Coordinator
    01 Jan 2016 - 31 Dec 2023 (Department)
  • Committee Members
    01 Jan 2022 - 31 Dec 2022 (Department of Medicine, Faculty of Medicine)
  • Member of Medical Advisory Council, UMMC
    01 Jan 2016 - 31 Dec 2021 (Department of Medicine, Faculty of Medicine)
  • Member of the Drug & Therapeutics Committee UMMC, Representative of Department of Medicine
    01 Jan 2016 - 31 Dec 2021 (Department of Medicine, Faculty of Medicine)
  • Chairman
    01 Jul 2021 - 31 Dec 2021 (Department of Medicine, Faculty of Medicine)
  • Endocrine Block Coordinator UMMP
    01 Jan 2014 - 01 Jul 2018 (Department of Medicine, Faculty of Medicine)
  • Ahli Jawatankuasa Penasihat Perubatan Pusat Perubatan Universiti Malaya
    01 Jan 2016 - 01 Jan 2017 (University Malaya)
  • Medical Department Clinical Coordinator Year 3 MBBS Examination
    01 Oct 2015 - 08 Jan 2016 (Department of Medicine, Faculty of Medicine)

MEMBERSHIPS

  • AHLI JAWATANKUASA PROGRAM FELLOWSHIP SUB-KEPAKARAN BIDANG ENDOKRINOLOGI, MEMBER
    2012 to present (National)
  • LIFE MEMBER MALAYSIAN ENDOCRINE AND METABOLIC SOCIETY, MEMBER
    Since 2000 (National)
  • MEMS RESEARCH GRANT APPLICATION SUB-COMMITTEE, COMMITTEE MEMBER
    2020 to 2023 (National)
  • NSR CERTIFIED INTERNAL MEDICINE PHYSICIAN AND ENDOCRINOLOGIST, MEMBER
    2018 to 2023 (National)
  • NSR CERTIFIED INTERNAL MEDICINE PHYSICIAN AND ENDOCRINOLOGIST, MEMBER
    2018 to 2023 (National)
  • MEMBER OF THE ENDOCRINE SOCIETY, MEMBER
    2022 to 2022 (International)
  • MEMBER OF THE DRUGS & THERAPEUTICS COMMITTEE, UMMC, MEMBER
    2018 to 2022 (University)
  • MEMBER OF THE ENDOCRINE SOCIETY OF USA, MEMBER
    2010 to 2021 (International)

AWARD AND STEWARDSHIP

  • 1st prize, poster(clinical sessions), Prevalence of bone-related endocrinopathies and its association with bone turnover markers among transfusion-dependent thalassemia patients
    Malaysian Society of Hematology Annual Scientific Conference 2016, 2016 (National)
  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2013 (University)
  • Certified Clinical Densitometrist
    International Society of Clinical Densitometry, 2011 (International)
  • First prize, Young Investigator Award, ASEAN Federation of Endocrine Societies Congress - Hypothalamic pituitary dysfunction among NPC survivors in Malaysia, J Ratnasingam et al.
    ASEAN Federation of Endocrine Societies(AFES), 2011 (International)
  • 1st prize for poster presentation, AOCE 2010, Kuala Lumpur
    Asia Oeania Congress of Endocrinology(AOCE), 2010 (International)
  • silver medal,Ekspo penyelidikan, rekacipta & inovasi 2007
    university of malaya, 2007 (University)
  • 3rd prize, poster presentation, 14th Congress of AFES 2007,Kuala Lumpur
    ASEAN Federation of Endocrine Societies(AFES), 2007 (International)

PUBLICATIONS

Article in Journal
WoS
  1. Perumalsamy, Sangeetha; Huri, Hasniza Zaman; Abdullah, Bashar Mudhaffar; Mazlan, Othman; Ahmad, Wan Azman Wan; Vethakkan, Shireene Ratna D. B. (2023). Genetic Markers of Insulin Resistance and Atherosclerosis in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease, METABOLITES. 13(3). doi:10.3390/metabo13030427
  2. Loganadan, N. K., Huri, H. Z., Vethakkan, S. R., & Hussein, Z. (2021). Pharmacogenetics of sulfonylurea-induced hypoglycemia in Type 2 diabetes patients: the SUCLINGEN study. Pharmacogenomics, 22(16), 1057-1068. doi: 10.2217/pgs-2021-0059
  3. Oo, M. M., Zhen, I. T. C., Ng, K. S., Tan, K. L., Tan, A. T. B., Vethakkan, S. R., . . . Chee, K. H. (2021). Observational study investigating the prevalence of asymptomatic stage B heart failure in patients with type 2 diabetes who are not known to have coronary artery disease. BMJ Open, 11(1), 8. doi: 10.1136/bmjopen-2020-039869
  4. Tan, E. Z. Y., Lai, L. L., Vethakkan, S. R., Mustapha, N. R. N., Mahadeva, S., & Chan, W. K. (2021). Modest alcohol intake not associated with significant hepatic steatosis or more severe liver disease among patients with diabetes mellitus. Journal of Gastroenterology and Hepatology, 36(3), 751-757. doi: 10.1111/jgh.15160
  5. Lai, L. L., Vethakkan, S. R., Mustapha, N. R. N., Mahadeva, S., Chan, W. K. (2020). Empagliflozin for the Treatment of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus. Digestive Diseases and Sciences, 65(2), 623-631. doi: 10.1007/s10620-019-5477-1
ESCI
  1. Bidin, Mohamed Badrulnizam Long; Khan, Abdul Mueed; Tan, Florence Hui Sieng; Aziz, Nor Azizah; Ali, Norhaliza Mohd; Kamaruddin, Nor Azmi; Vethakkan, Shireene Ratna; Sethi, Balraj; Hussein, Zanariah (2023). Patient Characteristics, Disease Burden, Treatment Patterns and Outcomes in Patients with Acromegaly: Real-World Evidence from the Malaysian Acromegaly Registry, JOURNAL OF THE ASEAN FEDERATION OF ENDOCRINE SOCIETIES. . doi:10.15605/jafes.038.01.06
Scopus
  1. Lim, S., Shireene, V., Vijay, A., Tan, T. B. A., Rokiah, P., Chan, S. P. (2007). Carbimazole-related agranulocytosis in pregnancy - a case report, Journal of the University of Malaya Medical Centre. 10(1), 34-38
Others
  1. Borhan MK, Vethakkan SR, Sarvanandan T, Paramasivam SS. A Case of Severe Lactation Ketoacidosis in a Nondiabetic Mother on a Ketogenic Diet. JCEM Case Reports. 2023 Nov;1(6):luad134.
  2. Chan WK, Chuah KH, Rajaram RB, Lim LL, Ratnasingam J, Vethakkan SR. Metabolic dysfunction-associated Steatotic Liver disease (MASLD): a state-of-the-art review. Journal of Obesity & Metabolic Syndrome. 2023 Sep 9;32(3):197.
  3. Hee NK, Lim QH, Paramasivam S, Lim LL, Vethakkan S, Ganapathy SS, Ratnasingam J. The use of prednisolone during Ramadan fasting in patients with adrenal insufficiency. Clinical Endocrinology. 2023 Nov 29.
  4. Long Bidin, M. B., Tan, F. H. S., Aziz, N. A., Mohd Ali, N. ., Kamaruddin, N. A., Vethakkan, S., Khan, A. M., Sethi, B., & Hussein, Z. (2022). Patient Characteristics, Disease Burden, Treatment Patterns and Outcomes in Patients with Acromegaly: Real-World Evidence from the Malaysian Acromegaly Registry. Journal of the ASEAN Federation of Endocrine Societies. Retrieved from https://www.asean-endocrinejournal.org/index.php/JAFES/article/view/2465
  5. Mendez-Sanchez, Nahum; Bugianesi, Elisabetta; Gish, Robert G.; Lammert, Frank; Tilg, Herbert; Nguyen, Mindie H.; Sarin, Shiv K.; Fabrellas, Nuria; Zelber-Sagi, Shira; Fan, Jian-Gao; Shiha, Gamal; Targher, Giovanni; Zheng, Ming-Hua; Chan, Wah-Kheong; Vinker, Shlomo; Kawaguchi, Takumi; Castera, Laurent; Yilmaz, Yusuf; Korenjak, Marko; Spearman, C. Wendy; Ungan, Mehmet; Palmer, Melissa; El-Shabrawi, Mortada; Gruss, Hans-Juergen; Dufour, Jean-Francois; Dhawan, Anil; Wedemeyer, Heiner; George, Jacob; Valenti, Luca; Fouad, Yasser; Romero-Gomez, Manuel; Eslam, Mohammed (2022). Global multi-stakeholder endorsement of the MAFLD definition, LANCET GASTROENTEROLOGY & HEPATOLOGY. 7(5), 388-390. doi:10.1016/S2468-1253(22)00062-0
  6. Sethi B, Al-Rubeaan K, Unubol M, Mabunay MA, Berthou B, Pilorget V, Vethakkan SR, Frechtel G. Efficacy and Safety of Insulin Glargine 300 U/mL in People with Type 2 Diabetes Uncontrolled on Basal Insulin: The 26-Week Interventional, Single-Arm ARTEMIS-DM Study. Diabetes Therapy. 2022 Jul;13(7):1395-408.
  7. Jalal FH, Ibrahim L, Lim QH, Chooi KC, Rajendran S, Ratnasingam J, Paramasivam SS, Vethakkan SR, Lim LL. What Does SGLT2 Inhibition Add in Managing Hyponatremia Secondary to Syndrome of Inappropriate Antidiuresis (SIAD)?. Journal of the Endocrine Society. 2021 Apr;5(Supplement_1):A619-20.
  8. Authors' reply re: Maternal lipids are associated with newborn adiposity independent of GDM status, obesity and insulin resistance: a prospective observational cohort study S Samsuddin, SR Vethakkan BJOG: An International Journal of Obstetrics & Gynaecology 127 (7), 912-913,2020
  9. Modest alcohol intake not associated with significant hepatic steatosis or more severe liver disease among patients with diabetes mellitus EZY Tan, LL Lai, SR Vethakkan, NR Nik Mustapha, S Mahadeva, WK Chan Journal of Gastroenterology and Hepatology, 2020
  10. Navin Kumar Loganadan, Hasniza Zaman Huri, Shireene Ratna Vethakkan, Zanariah Hussein. Clinical and genetic predictors of secondary sulfonylurea failure in type 2 diabetes patients: The SUCLINGEN study, Pharmacogenomics 2020, 10.2217/pgs-2019-0171 (published online May 29 2020)
  11. Retention of Carotenes and Vitamin E, and Physico-chemical Changes Occurring upon Heating Red Palm Olein Using Deep-fat Fryer, Microwave Oven and Conventional Oven R Loganathan, AHA Tarmizi, SR Vethakkan, KT Teng - Journal of oleo science, 2020
  12. Samsuddin S, Arumugam PA, Md Amin MS, Yahya A, Musa N, Lim LL, Paramasivam SS, Ratnasingam J, Ibrahim L, Chooi KC, Tan ATB, Tan PC, Omar SZ, Samingan N, Kamar AA, Anuar Zaini A, Jalaluddin MY, Vethakkan SR. (2020). Maternal lipids are associated with newborn adiposity independent of GDM status, obesity and insulin resistance: a prospective observational cohort study. BJOG;127(4):490 499. doi:10.1111/1471-0528.16031 (IF 5.193)
  13. Storage Stability Assessment of Red Palm Olein in Comparison to Palm Olein R Loganathan, AHA Tarmizi, SR Vethakkan, KT Teng - Journal of oleo science, 2020
  14. Thermal Stability and Sensory Acceptance of Cupcakes Containing Red Palm Olein R Loganathan, AHA Tarmizi, SR Vethakkan, TK Tiu - Journal of Oleo Science, 2020
  15. Lai LL, Vethakkan SR, Nik Mustapha NR, Mahadeva S, Chan WK. Empagliflozin for the Treatment of Nonalcoholic Steatohepatitis in Patients with Type 2 Diabetes Mellitus. Dig Dis Sci 2019, in press.
  16. "Red palm olein supplementation on cytokines, endothelial function and lipid profile in centrally overweight individuals: a randomised controlled trial" by Radhika Loganathan, Shireene Ratna Vethakkan, Ammu Kutty Radhakrishnan, Ghazali Razak, and Teng Kim-Tiu
  17. Continuous Glucose Monitoring Results in Lower HbA1c in Malaysian Women with Insulin Treated Gestational Diabetes: A Randomized Controlled Trial' SS Paramasivam, K Chinna, AKK Singh, J Ratnasingam, L Ibrahim, LL Lim, ATB Tan, SP Chan, PC Tan, SZ Omar, RW Bilous, SR Vethakkan. Diabetic Medicine (In press)
  18. Lai, L. L., Yusoff, W. N. I. W., Vethakkan, S. R., Mustapha, N. R. N., & Chan, W. K. (2018, November). Screening for nonalcoholic fatty liver disease and advanced liver fibrosis in patients with type 2 diabetes mellitus using controlled attenuation parameter and liver stiffness measurements. In JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY(Vol. 33, pp. 424-424
  19. Lai, L.L., Wan Yusoff, W.N.I., Vethakkan, S.R., Nik Mustapha, N.R., Chan W.K., (2018).Screening for non-alcoholic fatty liver disease in patients with type 2 diabetes mellitus using transient elastography. Journal of Gastroenterology and Hepatology. doi:10.1111/jgh.14577
  20. Perumalsamy S, et al. Chemokine-like Receptor 1(CMKLR-1) Receptor: A potential therapeutic target in management of Chemerin induced Type 2 Diabetes Mellitus and Cancer. Current Pharmaceutical Design 2017; vol 23, No. 25
  21. Ratnasingam, J., Chooi, K. C., Samsuddin, S., Paramasivam, S., Ibrahim, L., Lim, L. L., Tan, A., Vethakkan, S. (2017). Visual Vignette. Endocr Pract, 23(6), 752. doi:10.4158/ep161568.Vv (IF 4.149)
  22. JL Jamaluddin, HZ Huri, SR Vethakkan. Clinical and genetic predictors of dipeptidyl peptidase-4 inhibitor treatment response in Type 2 diabetes mellitus. Pharmacogenomics 2016
  23. L F Chang, SR Vethakkan, K Nesaretnam, TAB Sanders and KT Teng. Effects of exchanging carbohydrate or monounsaturated fat with saturated fat on inflammatory and thrombogenic responses in subjects with abdominal obesity: a randomized controlled trial. Clinical Nutrition(in press)
  24. Lim LL, Brnabic AJ, Chan SP, Ibrahim L, Paramasivam SS, Ratnasingam J, Vethakkan SR, Tan AT. The Relationship of HbA1c, Fasting and Postprandial Hyperglycemia in Subjects with Type 2 Diabetes Mellitus in Malaysia. J Diabetes Investig 2016 Nov 14
  25. Moy FM, Hoe VC, Hairi NN, Vethakkan SR, Bulgiba A: Vitamin D deficiency and depression among women from an urban community in a tropical country. Public Health Nutrition 2016, FirstView:1-7. doi:10.1017/S1368980016000811
  26. NB Kasim, HZ Huri, SR Vethakkan, L Ibrahim, BM Abdullah. Genetic polymorphisms associated with overweight and obesity in uncontrolled Type 2 diabetes mellitus.Biomarkers in Medicine, 2016; vol 10(4):403- 415
  27. Teng KT et al. Adverse effects on insulin secretion of replacing saturated fat with refined carbohydrate but not with monounsaturated fat: a randomized controlled trial in centrally obese subjects. Journal of Clinical Lipidology 2016(in press)
  28. Venugopal Y, Hatta SFWM, Musa N, Rahman SA, Ratnasingam J, Paramasivam SS, Lim LL, Ibrahim L, Choong K, Tan ATB, Chinna K, Chan SP, Vethakkan SR. MAINTENANCE VITAMIN D3 DOSAGE REQUIREMENTS IN CHINESE WOMEN WITH POST MENOPAUSAL OSTEOPOROSIS LIVING IN THE TROPICS. Asia Pacific Journal of Clinical Nutrition(in press)
  29. Hasniza Zaman Huri, Navin Loganadan, Shireene Ratna Vethakkan, and Zanariah Hussein.'Genetic markers predicting sulphonylurea treatment outcomes in Type 2 Diabetes patients: current evidence and challenges for clinical implementation'The Pharmacogenomics Journal
  30. S Khan, R Saub, RD Vaithilingam, SH Safii, SR Vethakkan and NA Baharuddin. Prevalence of chronic periodontitis in an obese population: A preliminary study. BMC Oral Health, 29 September 2015
  31. T. Arumugama, S. N. O. Razalia, S. R. Vethakkan, F. I. Rozallic and N. Shahrizailaa.Relationship between ultrasonographic nerve morphology and severity of diabetic sensorimotor polyneuropathy.European J of Neurology 2015.doi:10.1111/ene.12836
  32. Tong WT,Vethakkan SR, Ng CJ. Why do some people with type 2 diabetes who are using insulin have poor glycaemic control? A qualitative study. BMJ Open 2015;5:e006407. doi:10.1136/bmjopen-2014-006407
  33. 14.RM Dallumal, SS Chua, D Wu, SR Vethakkan Sitagliptin: Is it effective in routine clinical practice? Int J Endocrinol
  34. 17.WK Chan, ATB Tan, SR Vethakkan, PC Tah, A Vijayananthan, KL Goh. Ultrasonography-diagnosed non- alcoholic fatty liver disease is not associated with prevalent ischemic heart disease among diabetics in a multiracial Asian hospital clinic population. Clinics and Research in Hepatology and Gastroenterology . Volume 38, Issue 3, June 2014, Pages 284 291
  35. 18.WK Chan, ATB Tan, SR Vethakkan, PC Tah, A Vijayananthan, KL Goh. Low physical activity and energy dense Malaysian foods are associated with non- alcoholic fatty liver disease in centrally obese but not in non-centrally obese patients with diabetes mellitus. Asia Pac J Clin Nutr
  36. HZ Huri, V Permalu, SR Vethakkan. Sliding-scale versus basal-bolus insulin in the management of severe or acute hyperglycemia in type 2 diabetes patients: A retrospective study PLOS ONE, 2014
  37. Huri HZ, Selamat N, Vethakkan SR.Factors Associated with Utilization of Dipeptidyl-4 Inhibitors in Patients with Type 2 Diabetes Mellitus: A Cross- SectionalRetrospective Study.International Journal of Endocrinology Volume 2014
  38. Jamaluddin J, Zaman Huri H, Vethakkan SR, Mustafa N. Pancreatic gene variants potentially associated with DPP-4 inhibitor treatment response in Type 2 Diabetes Mellitus. Pharmacogenomics
  39. Ratnasingam J, Karim N, Paramasivam SS, Ibrahim L, Lim LL, Tan AT, Vethakkan SR, Jalaludin A, Chan SP. Hypothalamic pituitary dysfunction amongst nasopharyngeal cancer survivors. Pituitary. 2014 Aug 19. [Epub ahead of print] Digital Object Identifier (DOI) 10.1007/s11102-014-0593-6
  40. The incretin response after successful islet transplantation. Transplantation 27 Jan 2014; 97(2)
  41. Chan WK,Tan ATB, Vethakkan SR, Tah PC, Vijayananthan A, Goh KL.Non-Alcoholic Fatty Liver Disease (NAFLD) in Diabetics Prevalence and Predictive Factors in a Multi-Racial Hospital Clinic Population in Malaysia.Journal of Gastroenterology and Hepatology 2013.28:1375-1383
  42. Ng CJ, Liew SM, Vethakkan SR, Abdullah A, Teng CL. Patient-adjusted versus health professional-adjusted insulin dosing for type 2 diabetes mellitus. Published Online: June 6, 2013.DOI: 10.1002/14651858.CD010574
  43. Ratnasingam J, Tan ATB, Vethakkan SR, Paramasivam SS, Ibrahim L, Lim LL, Choong K. Primary Hyperparathyroidism: A Rare Cause Of Genu Valgus In Adolescence. J Clin Endocrinol Metab 2013;98(3)
  44. Shireene R Vethakkan , Yogeswari Venugopal, Alexander T.B. Tan, Sharmila S. Paramasivam, Jeyakantha Ratnasingam, Rohaya A.Razak, Azmi Alias, Fauziah Kassim, Karen Choong. Hypothalamic germinoma masquerading as superior mesenteric artery syndrome. Endocrine Practice 2013;19(1):e29-e34
  45. Syed Ikmal SIQ, Zaman Huri H, Vethakkan SR, Wan Ahmad WA. Potential biomarkers of insulin resistance and atherosclerosis in Type 2 Diabetes Mellitus patients with Coronary Artery Disease. International Journal of Endocrinology 2013
  46. Yogeswari Venugopal, Shireene Vethakkan, Sargunan Sockalingam, Raja Jasmin, Karen Choong.A CASE OF PERSISTENT HYPOGLYCEMIA: WHEN TO THINK OUTSIDE THE BOX. Clinical Diabetes.Volume 31,Number 3,2013.pg 130- 133
  47. Vethakkn SR, Walters JM, Gooley JL et al. Normalized NEFA dynamics during an OGTT after islet transplantation. Transplantation 2012:94(7):e49-e51
  48. Vethakkan SR, Jenkins AJ, Kay TWH et al.2010. Improved second phase insulin secretion and preserved insulin sensitivity after islet transplantation. Transplantation 89:1291-1292
  49. Vethakkan SR, Roberts V, Ward GM.2009. Sudden onset of haemoptysis and hypoxia after recombinant human thyroid-stimulating hormone use in a patient with papillary thyroid carcinoma and pulmonary metastases. Internal Medicine Journal 39(12):854-855
  50. Vethakkan SR, Walters JM, Gooley JL et al.2009. Application of the intravenous glucose tolerance test and the minimal model to patients with insulinoma:insulin sensitivity(Si) and glucose effectiveness(Sg) before and after surgical excision. Clinical Endocrinology ;70:47-52
  51. Lim SS, Shireene V, Vijay A, Tan TBA, Rokiah P, Chan SP.2007. "Carbimazole-related agranulocytosis in pregnancy - a case report" Journal of the University of Malaya Medical Centre(JUMMEC), 10(1):34-38
Article in Proceeding
  1. Bernard DM, Wen LS, Yoong NH, Hziung LQ, Lachumanan D, Paramasivam SS, Ling LL, Ratnasingam RJ, Aman RR, Vethakkan SR. ACROMEGALY WITH SPONTANEOUS VENTRICULOSTOMY-A RARE PHENOMENON. Journal of the ASEAN Federation of Endocrine Societies. 2022 Jul 15;37(S2):44-5.
  2. Hee NK, Lim QH, Lim LL, Paramasivam S, Vethakkan S, Chan SP, Ratnasingam J. ODP173 Control of Alpelisib-Induced Hyperglycemia With DPP4-Inhibitors as add on to Metformin and Insulin. Journal of the Endocrine Society. 2022 Nov;6(Supplement_1):A303-.
  3. Loganadan NK, Huri HZ, Vethakkan SR, Hussein Z. IDF21-0069 Beta-cell function and insulin resistance of type 2 diabetes patients on maximum doses of sulphonylurea-metformin. Diabetes Research and Clinical Practice. 2022 Apr 1;186.
  4. Murthy T, Shander S, Lim LL, Vethakkan S, Paramasivam S. PREDICTIVE FACTORS FOR FAILURE OF FIRST RADIOACTIVE IODINE THERAPY IN PATIENTS WITH HYPERTHYROIDISM. Journal of the ASEAN Federation of Endocrine Societies. 2022 Jul 15;37(S2):16-.
  5. Ng YM, Ratnasingam J, Lim LL, Paramasivam SS, Ibrahim L, Lim QH, Chiong TP, Omar SZ, Vethakkan SR. IDF21-0025 Impact of different GDM diagnostic criteria on GDM incidence, therapy and postpartum dysglycemia in Malaysian women. Diabetes Research and Clinical Practice. 2022 Apr 1;186. https://doi.org/10.1016/j.diabres.2022.109699
  6. Ooi XY, Aziz NI, Lim LL, Paramasivam S, Vethakkan S, Chan SP, Suhaimi A, Ratnasingam J. ODP346 Prevalence and Predictors of Endocrinopathies Amongst Patients on Chronic Opioid Use for Non-Cancer Pain. Journal of the Endocrine Society. 2022 Nov 11;6(Suppl 2):A507.
  7. Tai YT, Lim QH, Ratnasingam J, Paramasivam SS, Tan PC, Omar SZ, Chinna K, Lim LL, Vethakkan SR. ODP413 Impact of Gestational Weight Gain according to 2009 IOM Recommendations on Neonatal Anthropometrics in Asians: A Pilot Study from Malaysia. J Endocr Soc. 2022 Nov 1;6(Suppl 1):A662. doi: 10.1210/jendso/bvac150.1369. PMCID: PMC9625168.
  8. SL Fong, MI Idris, SKY Hung, BHS Ng, KC Chooi, SR Vethakkan, CY Tan Acute flaccid paralysis:Guillain Barre Syndrome mimics Clinical Neurophysiology 132 (8), e111-e112
  9. OR11-5 Early Prevalence of Neuroendocrine Dysfunction after Spontaneous Aneurysmal Subarachnoid Haemorrhage: Interim Findings from a Prospective Cohort Study KC Chooi, J Ratnasingam, S Paramasivam, L Ibrahim, A Tan, Q Lim, ... Journal of the Endocrine Society 3 (Supplement_1), OR11-5
  10. J Ratnasingam, N Karim, S Paramasivam, A Tan Tong Boon, S Vethakkan, K Choong, R Pendek, S Chan. Increased risk of hypothalamic pituitary dysfunction amongst nasopharyngeal carcinoma survivors with the use of concurrent chemo-irradiation. Endocrine Abstracts (2012), Vol 29, P1409
  11. K Choong, Y Venugopal, S Vethakkan, R Pendek. A case of persistent hypoglycemia in the setting of connective tissue disease. Endocrine Abstracts (2012), Vol 29, P425
  12. Ward GM, Walters JM, Vethakkan SR, Gooley JL, Goodman DJ, Jenkins AJ, Boston RC, Holmes-Walker DJ, O'Connell P, Kay TWH. Sustained improvement in NEFA suppression during IVGTT 3 years after islet-transplantation.
  13. Vethakkan SR, Walters JM, Gooley JL, Boston RC, Kay TWH, Goodman DJ, Jenkins AJ, Holmes-Walker DJ, Ward GM. The Incretin Response Post-Islet-Transplantation. Diabetes 2011;60(Suppl 1): A46
  14. G. Ward, Islet Tx Study Group.2010 NEFA kinetics during an OGTT after islet transplantation. Diabetologia 53(Suppl 1). S266
  15. Vethakkan SR et al.2010. NEFA kinetics during an OGTT after islet transplantation.Journal of Endocrinology and Metabolism. 1(Supplement Issue No. 2): pg. 77
  16. G Ward, AJ Jenkins, TWH Kay, DJ Goodman, JM Walters, JL Gooley, RC Boston, JD Holmes-Walker, SR Vethakkan. Measuring insulin secretion and sensitivity in an islet transplant patient.Meeting Proceedings and Abstract Book, pg 206
  17. Vethakkan SR et al. 2007.A New Application of the Intravenous Glucose Tolerance Test in Patients with Insulinoma.Journal of the ASEAN Federation of Endocrine Societies.
  18. Rokiah Pendek, WJ Loh, WF Chew, V Shireene, SS Lim, A Vijay et al. 2005. Prevalence of the metabolic syndrome attending an outpatient Diabetes Clinic, University of Malaya Medical Centre, Preliminary Analysis.Journal of the ASEAN Federation of Endocrine Societies Vol 23 (Suppl. No. 1)
Other Publications
  1. Clinical Practice Guidelines for management of obesity, 2nd edition, 2023 - Technical Report
  2. clinical practice guidelines for management of obesity(2nd edition) 2023 - Policy Paper

RESEARCH INTEREST

  • Pituitary dysfunction among nasopharyngeal cancer survivors in PPUM
  • PREVALENCE OF VITAMIN D DEFICIENCY IN WOMEN WITH POST-MENOPAUSAL OSTEOPOROSIS AND DETERMINATION OF THE VITAMIN D DOSE TO REVERSE DEFICIENT STATES
  • Dietary fats and insulin sensitivity and cardiovascular health
  • Factors influencing the control of diabetes in patients with type 2 diabetes taking insulin

RESEARCH PROJECT

National
  1. 2019 - 2022, RU Geran - Fakulti Program
    Plasma Adiponectin, Glycaemic Control And Insulin Use In Women With Gestational Diabetes Mellitus: A Prospective, Observational Study ( Principal Investigator(PI))
  2. 2022 - 2024, DEPARTMENT OF MEDICINE (DOM)
    Prevalence and phenotypic variability of overweight and obesity among healthcare workers in University of Malaya Medical Centre ( Co-Researcher)
  3. 2022 - 2023, Malaysian Endocrine and Metabolic Society Research Grant
    Brain Natriuretic Peptide: A Predictor of Adverse Outcomes In Thyroid Storm, Ministry of Health Malaysia ( Co-Researcher)
  4. 2014 - 2016, Geran Penyelidikan Universiti Malaya (UMRG)
    Genetic predictors in uncontrolled type 2 diabetes mellitus with obesity patients ( Principal Investigator(PI))
  5. 2011 - 2013, Geran Penyelidikan Universiti Malaya (UMRG)
    Effects of Combined Aerobic and Resistance Exercise vs Aerobic Exercise vs Resistance Exercise Training for Type 2 Diabetes complicated with coronary artery disease ( Consultant)
  6. 2010 - 2012, Geran Penyelidikan Universiti Malaya (UMRG)
    Pituitary dysfunction among nasopharyngeal cancer survivors in PPUM ( Principal Investigator(PI))
  7. 2007 - 2008, Postgraduate Research Grant(PPP)
    Real Time PCR Studies to Confirm Paraoxonase 1 Genotype ( Consultant)
  8. 2007 - 2008, Postgraduate Research Grant(PPP)
    Real time PCR studies to confirm Paraoxonase 1 genotype ( Consultant)
Private
  1. 2019 - 2021, Allergan Malaysia Sdn. Bhd.
    A 46-week, Double-blind, Placebo-controlled, Phase 3 Study with a 6-week Randomized-withdrawal Period to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis ( Principal Investigator(PI))
  2. 2019 - 2021, Allergan Malaysia Sdn. Bhd.
    A 52-week, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Safety and Efficacy of Relamorelin in Patients with Diabetic Gastroparesis ( Principal Investigator(PI))
International
  1. 2022 - 2025, ASTRAZENECA SDN. BHD.
    A Phase IIb/III Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Cotadutide in Participants with Non-cirrhotic Non-alcoholic steatohepatitis with Fibrosis (PROXYMO-ADVANCE) ( Co-Researcher)
  2. 2021 - 2023, BOEHRINGER INGELHEIM SINGAPORE PTE. LTD.
    Multicenter, double-blind, parallel-group, randomised, 48 weeks, dose-ranging, placebo-controlled phase II trial to evaluate efficacy,safety and tolerability of multiple subcutaneous (s.c.) doses of BI 456906 in patients with non-alcoholic steatohepatitis (NASH) and fibrosis ( Co-Researcher)
  3. 2021 - 2022, ABBOT MANUFACTURING SINGAPORE PTE LTD
    A randomized controlled trial to determine the effects of a diabetes-specific formula on long-term glycemic control and short-term glycemic variability in individuals with type 2 diabetes. ( Co-Researcher)
  4. 2019 - 2022, KPM (JPT), Medical Research Council, UK (MRC,UK)
    Using big data to improve population health and resource allocation for people with diabetes in Malaysia ( Co-Researcher)
  5. 2019 - 2022, KPM (JPT), Medical Research Council, UK (MRC,UK)
    Using big data to improve population health and resource allocation for people with diabetes in Malaysia ( Co-Researcher)
  6. 2020 - 2022, Others MOHE
    Impact of multicomponent integrated care on clinical events and hospitalization in people with type 2 diabetes: 8 years of follow-up in the randomized JADE Malaysia study ( Consultant)

CONSULTANCY PROJECT

  • Committee Member for The Revision of 'Cpg for The Management of Obesity', Malaysian Endocrine & Metabolic Society
    01 Nov 2019 - 01 Nov 2022 (National)
  • Member of 2019 Taskforce for The Update of The 2015 Cpg for Management of T2dm (5th Edition), Malaysian Endocrine & Metabolic Society
    01 Nov 2019 - 01 Nov 2020 (National)
  • Principal Investigator, Evolve Study-An International Non-Interventional Prospective Cohort Study to Evaluate The Safety of Treatment With Levemir in Pregnant Women With Diabetes, Novo Nordisk
    01 Dec 2017 - 01 Dec 2019 (International)
  • Prinicipal Investigator , Basalog Study -Post-Marketing Surveillance of Basalog, CCM
    01 Dec 2016 - 01 Dec 2017 (International)
  • Subinvestigator : "a Multicentre Randomized Program to Compare The Effect of The Joint Asia Diabetes Evaluation(Jade, Structured Care) Versus The Diabetes Monitoring Database(Diamond, Usual Care)Programs in Type 2 Diabetic Patients in Asia Pacific Region, JADE/DIAMOND steering committee(Chinese University of Hong Kong)
    01 Nov 2013 - 01 Nov 2015 (International)
  • Pricipal Investigator for Cascade-7(Clinical Trial Program of a Novel Sglt-2 Inhibitor for Glycaemic Control, Tolerability and Safety in Patients With Type 2 Diabetes)(1245.28), Boehringer-Ingelheim
    01 Jul 2011 - 01 Jul 2013 (International)
  • Diabcare Asia Study, Principal Investigator, Novo Nordisk
    01 Jan 2013 - 01 Jan 2013 (International)
  • Principal Investigator -Cantata-D Trial(Canagliflozin Treatment and Trial Analysis-Dpp4 Inhibitor Comparator Trial), Janssen-Cilag
    01 Jul 2010 - 01 Jul 2012 (International)
  • Subinvestigator for Cascade-5 (Clinical Trial Program of a Novel Sglt-2 Inhibitor for Glycaemic Control, Tolerability and Safety in Patients With Type 2 Diabetes)(1245.36), Boehringer-Ingelheim
    01 Jul 2011 - 01 Jul 2012 (International)
  • Principal Investigator - The Cantata-M Trial (Canagliflozin Treatment and Trial Analysis - Monotherapy), Janssen-Cilag
    01 Jul 2010 - 01 Jul 2012 (International)
  • Krx101-401 Sub-Investigator for The Collaborative Study Group Trial: The Effect of Sulodexide in Overt Type 2 Diabetic Nephropathy, Keryx Biopharmaceuticals Inc.
    01 Jan 2005 - 01 Jan 2008 (International)
  • Sub-Investigator for Charisma(Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance) Trial-Efc 4505, Bristol-Myers Squibb Pte. Ltd.
    01 Jul 2003 - 01 Jul 2005 (International)

PAPER PRESENTED

PLENARY SPEAKER
  1. Individualized Treatment Targets in Diabetes, National Diabetes Conference, Persatuan Diabetes Malaysia (National) (21 Jun 2014 - 21 Jun 2014)
  2. Stem Cells and Islet Transplants: State of the Art, National Diabetes Conference 2013, Persatuan Diabetis Malaysia (National) (15 Jun 2013 - 15 Jun 2013)
INVITED SEMINAR
  1. Diabetes and wound care, Malaysian Diabetes Education Society National Conference 2016, Malaysian Diabetes Education Society (National) (22 Apr 2016 - 22 Apr 2016)
INVITED SPEAKER
  1. Diabetes in Pregnancy , UM Advanced Course in Diabetes, Endocrine Unit, Department of Medicine, UMMC (National) (09 Dec 2022 - 09 Dec 2022)
  2. Real World Diabetes Management In-patient: Is the traditional approach sufficient?, UMPIRE Workshop(UMMC Multi-Discipline Insulin Workshop Edition 1.0), UMMC (University) (10 Sep 2022 - 10 Sep 2022)
  3. Autoimmune polyglandular syndrome, 12th MEMS Annual Congress 2022 (MAC12) held from 15th to 17th July 2022 at Hilton & Le Meridien Kuala Lumpur, Malaysia, MEMS(Malaysian Endocrine and Metabolic Society) (National) (15 Jul 2022 - 17 Jul 2022)
  4. Clinical Practi ce Guidelines Managementof Type 2 Diabetes Mellitus , Webinar # 3 Complications-Retinopathy, Clinical Practi ce Guidelines Managementof Type 2 Diabetes Mellitus (6th Editi on) Rollout, Webinar # 3, Malaysian Endocrine and Metabolic Society (National) (08 Jan 2022 - 08 Jan 2022)
  5. Congenital Adrenal Hyperplasia: Transition to Adulthood, Late Onset CAH , 10th Malaysian Endocrine and Metabolic Society Annual Congress(MAC10) Invited Speaker at Symposium , Malaysian endocrine and Metabolic Society  (National) (19 Jul 2019 - 21 Jul 2019)
  6. Long-term consequences of GDM in mother and offspring, 12 th International Diabetes Federation-West Pacific Region Congress 2018 , IDF (International) (23 Nov 2018 - 25 Nov 2018)
  7. Antihypertensive therapy in patients with diabetes, Malaysian Society of Hypertension Annual Congress, Malaysian Society of Hypertension (National) (11 Mar 2017 - 11 Mar 2017)
  8. Polyuria- is it diabetes insipidus, MEMS endocrine update, Malaysian Endocrine and Metabolic Society (National) (22 Oct 2016 - 22 Oct 2016)
  9. Management of hyperglycemia in pregnancy, Malaysian Endocrine and Metabolic Society Annual Conference 2016, Malaysian endocrine and metabolic society (National) (22 May 2016 - 22 May 2016)
  10. updates in diabetes management, 1st Global Manipal Alumni Health, Science & Technology Convention (National) (08 Aug 2014 - 08 Aug 2014)
  11. Type 2 DM co-morbidities influencing metabolic control, UMMC Cardio-Metabolic Workshop 2014 Date: 22 February 2014 (Saturday) , UMMC (University) (22 Feb 2014 - 22 Feb 2014)
  12. Managing CAH in adults, MEMS Annual Congress 2013, Malaysian Endocrine and Metabolic Society (National) (24 May 2013 - 24 May 2013)
  13. Cardiovascular Risk and Diabetic Therapy, National Heart Association of Malaysia Annual Scientific Meeting 2013, NHAM (National) (13 Apr 2013 - 13 Apr 2013)
  14. Bariatric Surgery for Metabolic Disorders, UMMC RUKA Workshop, Endocrine Unit, Primary Care Medicine Department UMMC (Others) (12 Jan 2013 - 12 Jan 2013)
  15. When and how do I start insulin, PDM conference 2012, Persatuan Diabetis Malaysia (National) (22 Jun 2012)
  16. Obesity and Gestational Diabetes Mellitus, Malaysian Diabetes Educators Society Seminar, Malaysian Diabetes Educators Society (National) (20 Apr 2012)
  17. The use of insulin in primary care, UMMC Primary Care CME (Others) (24 Mar 2012)
  18. Initiating Insulin Therapy, Weekend Seminar in Cardiology (18 Feb 2012)
  19. Initiation of insulin, Masterclass on urology and diabetes for general practice, Medical Progress (Others) (02 Oct 2011)
  20. Insulin pump in type 2 diabetes, MEMS Annual Congress 2011 (National) (22 May 2011)
  21. Initiation of insulin therapy, GP Symposium, Academy of Family Physicians (National) (16 Apr 2011)
  22. New oral antidiabetic agents, GP Symposium, Academy of Family Physicians (National) (16 Apr 2011)
  23. Islet transplantation, National Diabetes Conference 2010, Persatuan Diabetes Malaysia (National) (30 Jul 2010 - 01 Aug 2010)
  24. Practical Aspects of Diabetes Monitoring, 2nd National Diabetes Education Seminar, Persatuan Diabetes Malaysia (National) (15 Jul 2005 - 17 Jul 2005)
  25. Management of Osteoporosis, Malaysian Endocrine and Metabolic Society(MEMS) Postgraduate Endocrine Meeting 2005, Malaysian Endocrine & Metabolic Society (National) (01 Jul 2005 - 03 Jul 2005)
  26. Management of Hypercalcemia, MEMS Postgraduate Endocrine Meeting 2004, Malaysian Endocrine & Metabolic Society (National) (01 May 2004)
ORAL PRESENTER
  1. Intravenous or Oral glucose challenges to predict insulin independence duration following islet transplantation in human type 1 diabetes, Australian Diabetes Society 2020 Sessions, Australian Diabetes Society (International) (11 Nov 2020 - 13 Nov 2020)
  2. Hypothalamic pituitary dysfunction amongst NPC survivors in Malaysia, 16th ASEAN Federation of Endocrine Societies Scientific Congress 2011 (International) (18 Nov 2011 - 20 Nov 2011)
  3. The incretin response post-islet-tranpslantation, ADA 71st Scientific Sessions 2011 (International) (24 Jun 2011 - 28 Jun 2011)
POSTER PRESENTER
  1. Relative impact of maternal triglyceride & glucose on neonatal adiposity in Asian mothers with normal glucose tolerance S. Samsuddin, P.A. Arumugam, A. Yahya, N. Musa, L.L. Lim, S.S. Paramasivam, J. Ratnasingam, L. Ibrahim, S.Z. Omar, M.Y. Jalaluddin, A. Ahmad Kamar, S.R. Vethakkan. , IDF (International Diabetes Federation) 2017, International Diabetes Federation (International) (04 Dec 2017 - 08 Dec 2017)
  2. Impact of maternal triglyceride and novel metabolic parameters on neonatal anthropometrics in Asians S. Samsuddin, P. Arul, M. Md Amin, A. Yahya, N. Musa, L.L. Lim, S.S. Paramasivam, J. Ratnasingam, L. Ibrahim, K.C. Chooi, A.T.B. Tan, P.C. Tan, A. Ahmad Kamar, A. Anuar Zaini, S.R. Vethakkan; , EASD(European Association for the Study of Diabetes) Annual Meeting 2017, EASD (International) (11 Sep 2017 - 15 Sep 2017)
  3. Delay in insulin secretion following an oral glucose load after islet transplantation in human type 1 diabetes., Australian Diabetes SocietyADEA 2017 Annual Scientific Meeting, Australian Diabetes Society  (International) (30 Aug 2017 - 01 Sep 2017)
  4. Regulation of alpha cell function and fatty acid levels by hyperinsulinemia after islet transplantation in Type 1 Dibabetes, Australian Diabetes Society Scientific Meeting, Australian diabetes society (International) (24 Aug 2016 - 26 Aug 2016)
  5. Association of rs5219 KCNJ11 Gene Polymorphism with Pancreatic Beta-Cell Function, Insulin Resistance, and Glycemic Control of Sulfonylurea-treated Malaysian Type 2 Diabetes Patients NAVIN K. LOGANADAN, HASNIZA ZAMAN HURI, SHIREENE R. VETHAKKAN, ZANARIAH HUSSEIN, American Diabetes Association 2016 Scientific Sessions, American Diabetes Association (International) (10 Jun 2016 - 14 Jun 2016)
  6. One Size Fits All? Comparing Efficacy of Standard Cholecalciferol Loading for Vitamin-D Deficiency in Malaysian Women of Different Ethnicities with Post-menopausal Osteoporosis, WCO-IOF-ESCEO, World congress on osteoporosis, osteoarthritis and musculoskeletal diseases 2016, WCO-IOF-ESCEO (International) (14 Apr 2016 - 17 Apr 2016)
  7. Prevalence of bone-related endocrinopathies and its association with bone turnover markers among transfusion dependent thalassemia patients, Malaysian Society of Haematology Scientific Meeting 2016, Malaysian Society of Haematology (National) (14 Apr 2016 - 16 Apr 2016)
  8. Maintenance Vitamin-D3 supplementation required to maintain sufficiency in Indian women with post-menopausal osteoporosis living in the tropics, World congress on osteoporosis, osteoarthritis and musculoskeletal diseases 2016, WCO-IOF-ESCEO (International) (14 Apr 2016 - 17 Apr 2016)
  9. The Effectiveness of CGM in Insulin-requiring GDM: A Randomized Trial , Annual EASD Scientific Meeting (International) (16 Sep 2014 - 16 Sep 2014)
  10. Prevalence and predictors of Vitamin D inadequacy in a multi-racial cohort of Vitamin D-supplemented women with postmenopausal osteoporosis living in the tropics, European Congress on Osteoporosis and Osteoarthritis 2013-International Osteoporosis Foundation (International) (17 Apr 2013 - 20 Apr 2013)
  11. Ward GM, Walters JM, Vethakkan SR, Gooley JL, Goodman DJ, Jenkins AJ, Boston RC, Holmes-Walker DJ, O'Connell P, Kay TWH. Sustained improvement in NEFA suppression during IVGTT 3 years after islet- transplantation, ADS-ADEA Scientific Meeting 2012, Australian Diabetes Society and Australian Diabetes Educators Society (International) (29 Aug 2012 - 31 Aug 2012)
  12. A case of persistent hypoglycemia in the setting of connective tissue disease, International congress of endocrinology (05 May 2012 - 09 May 2012)
  13. Increased risk of hypothalamic pituitary dysfunction amongst nasopharyngeal carcinoma survivors with the use of concurrent chemo-irradiation, International Congress of Endocrinology (International) (05 May 2012 - 09 May 2012)
  14. NEFA kinetics during an OGTT after islet transplantation, Asia Oceania Congress of Endocrinology 2010, Asia Oceania Congress of Endocrinology (International) (02 Dec 2010 - 05 Dec 2010)
  15. NEFA kinetics during an OGTT after islet transplantation, EASD 2010, European Association for the Study of Diabetes (International) (20 Sep 2010 - 24 Sep 2010)
  16. Measuring insulin secretion and sensitivity in an islet transplant patient, ADS-ADEA Annual Scientific Meeting 2009(Australian Diabetes Society & Australian Diabetes Educators Association), ADS-ADEA (International) (26 Aug 2009 - 28 Aug 2009)
  17. A New Application of the Intravenous Glucose Tolerance Test in Patients with Insulinoma, 14th Congress of ASEAN Federation of Endocrine Societies, ASEAN Federation of Endocrine Societies (International) (30 Nov 2007 - 02 Dec 2007)
  18. Undiagnosed epinephrine-secreting phaeochromocytoma mimicking thyroid storm and septic shock - a case report., 14th Congress of ASEAN Federation of Endocrine Societies, 2007, ASEAN Federation of Endocrine Societies (International) (30 Nov 2007 - 02 Dec 2007)
  19. Assessment of Paraoxonase Activity in Diabetic Subjects with Hyperlipidemia, Ekspo Penyelidikan, Rekacipta & Inovasi 2007, Universiti of Malaya (University) (26 Jul 2007 - 28 Jul 2007)
  20. Prevalence of Metabolic Syndrome in patients attending an outpatient clinic, University Malaya Medical Centre, preliminary analysis - comparison among WHO(1998),NCEP(2001) & IDF(2005) definitions. , 13th Congress of the ASEAN Federation of Endocrine Societies, ASEAN Federation of Endocrine Societies (International) (07 Dec 2005 - 10 Dec 2005)
  21. Prevalence of Metabolic Syndrome in a rural population in Malaysia - comparison between the ATPIII(2004), WHO(1998) and the 2005 IDF Consensus Guidelines., 13th Congress of the ASEAN Federation of Endocrine Societies, ASEAN Federation of Endocrine Societies (International) (07 Dec 2005 - 10 Dec 2005)
OTHERS
  1. Impact of Maternal Triglyceride and Novel Metabolic Parameters on Neonatal Anthropometrics in Asians, American Diabetes Association Scientific Sessions 2016, American Diabetes Association (International) (10 Jun 2016 - 14 Jun 2016)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2023) Chairperson , Phd Proposal Defence for Sarkaaj Singh, University, (Reviewer)
  2. (2023) Chairperson, Proposal Defence Committee for Masters of Medical Science Candidate Samuel Lee-Boey, University, (Reviewer)
  3. (2023) Internal Examiner for Candidate Jia Xin Hoo, Medical Masters of Science, University, (Internal Examiner)
  4. (2023) Chair, Proposal Defence Evaluation Committee for Harvinder Kaur, University, (Reviewer)
  5. (2022) Examiner-Program Ijazah Sarjana Perubatan Dalaman, National, (External Examiner)
  6. (2022) Reviewer of Applicants for Umsc C.a.R.E Research Grant, University, (Internal Assessor)
  7. (2022) Examiner for Clinical Masters of Internal Medicine Thesis, University, (Internal Examiner)
  8. (2022) Chair of Committee of Internal Examiners for Masters of Medical Science Proposal Defence-Muhammad Navid Bin Mohamad Sithik ( S2100668/1 ) Title: Association Between Erectile Dysfunction and Cardiovascular Disease Among Malaysians With Type 2diabetes Mellitus, University, (Internal Examiner)
  9. (2022) Assessment of Masters of Internal Medicine Thesis Proposal, University, (Internal Assessor)
  10. (2021) Committee Member of Jawatankuasa UKM Untuk Kesepakaran Kenaikan Pangkat Ke Jawatan Profesor Madya Gred Ds54, National, (External Assessor)
  11. (2021) Chair of Proposal Defence Committee, M Med Sc_alia Abdul Aziz, University, (Internal Assessor)
Contribution to external organisation
  1. (2024) Ahli Jawatankuasa Program Fellowship Sub-Kepakaran Bidang Endokrinologi, National, (Expert Advisor)
  2. (2023) Task Force Member for Diabetes Education Manual 3rd Edition, National, (Expert Advisor)
  3. (2023) Member of Mems Research Grant Application Sub-Committee., National, (Expert Advisor)
  4. (2022) Member of Mems Research Grant Application Subcommittee, National, (Expert Advisor)
  5. (2022) Member of The Obesity Cpg Development Committee, National, (Expert Advisor)
  6. (2022) Member of Obesity Cpg Development Committee, National, (Expert Advisor)
  7. (2021) Member of Taskforce to Update of Cpg T2dm 2020(6th Edition), National, (Expert Advisor)
  8. (2021) Ahli Mesyuarat Jawatankuasa Program Fellowship Sub-Kepakaran Bidang Endokrinologi, Kementerian Kesihatan Malaysia, National, (Expert Advisor)
Contribution to event
  1. (2022) Judge of The Young Investigator (Research) Award, Mac 12(Mems Annual Congress 12), National, (Panelist/Moderator)
  2. (2021) Invited Speaker /UM Masterclass/Secondary Hypertension, University, (Panelist/Moderator)
  3. (2021) Invited Speaker/Webcast On The Topic "Screening for Early Gdm", National, (Panelist/Moderator)
  4. (2021) Invited Speaker/Meet The Expert/Difficult Diabetes in Pregnancy, National, (Panelist/Moderator)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2020) RED PALM OLEIN STABILITY AND ITS EFFECTS ON CARDIOVASCULAR HEALTH., RADHIKA LOGANATHAN
  2. (2020) FILLING THE GAPS IN NON-ALCOHOLIC FATTY LIVER DISEASE - FROM SCREENING TO ASSESSMENT AND TREATMENT, LAI LEE LEE
  3. (2019) FILLING THE GAPS IN NON-ALCOHOLIC FATTY LIVER DISEASE - FROM SCREENING TO ASSESSMENT AND TREATMENT, LAI LEE LEE
  4. (2019) CLINICAL AND GENETIC PREDICTORS OF SECONDARY SULPHONYLUREA FAILURE AND SULPHONYLUREA-INDUCED HYPOGLYCEMIA IN MALAYSIAN TYPE 2 DIABETES PATIENTS: A PROSPECTIVE MULTICENTRE STUDY (SUCLINGEN), NAVIN KUMAR A/L LOGANADAN
  5. (2016) CLINICAL AND GENETIC ASSOCIATIONS OF DIPEPTIDYL PEPTIDASE-INHIBITOR TREATMENT RESPONSE IN TYPE 2 DIABETES., JAZLINA LIZA BT. JAMALUDDIN
  6. (2015) Partial meal replacement as compared to conventional reduced calorie diet: a prospective study of modification of weight change, nutritional status and metabolic control in obese patients with type 2 diabetes mellitus, Lee Ching Li (M0100536)
  7. (2015) Clinical & Genetic Predictors of Sulphonylurea Response among Malaysian Type 2 Diabetes Patients., navin kumar a/l loganadan
  8. (2012) Clinical and genetic markers of DPPIV inhibitor treatment response in type 2 diabetes mellitus, JAZLINA LIZA BT. JAMALUDDIN
  9. (2005) ACTIVITY AND POLYMORPHISM OF PARAOXONASE 1 IN THE MALAYSIAN POPULATION, ROZAIDA @ POH YUEN YING
Master
  1. (2022) -, SHAMIMAH BINTI SAHUL HAMEED
  2. (2022) -, SHAMIMAH BINTI SAHUL HAMEED
  3. (2021) -, MOHAMMAD AKRAM M RAMLI
  4. (2020) COMPARISON OF DIFFERENT DIAGNOSTIC CRITERIA FOR GDM IN MALAYSIAN WOMEN AND ITS IMPACT ON IT'S INCIDENCE AND MATERNO-FETAL OUTCOME, JESLYN ANG
  5. (2018) ASSOCIATIONS OF GENETIC POLYMORPHISMS AND CLINICAL PARAMETERS WITH POOR GLYCAEMIC CONTROL IN OVERWEIGHT AND OBESE TYPE 2 DIABETES MELLITUS PATIENTS., NOR BAHIRAH BINTI KASIM
  6. (2018) -, NUR DALILA BINTI NOOR AZMAN SHAH
  7. (2016) PILOT STUDY OF PREDICTORS OF GESTATIONAL DIABETES MELLITUS AMONG ASIANS, JAYALAKSMI A/P RAMASAMY
  8. (2015) Vitamin D dose supplementation requirements amongst Indian and Malay women in the tropics, Goh Kian Guan
  9. (2015) The relationship between pregravid BMI and maternal hypertriglyceridemia during pregnancy with offspring neonatal adiposity in Malaysians, Premila Arul
  10. (2015) Relationship between novel maternal metabolic factors and offspring birth weight in Malaysian mothers, Syahrizan bt Samsuddin (000000269)
  11. (2015) Clinical Supervision Endocrine Subspecialty Training, Luqman Ibrahim
  12. (2015) Clinical Supervision Endocrine Subspecialty Training, Lim Lee Ling
  13. (2015) clinical subspecialty training, endocrine fellowship, Raja NurAzni (000000012)
  14. (2014) The effect of professional Continuous Glucose Monitoring on glycemic control and hypoglycemia in insulin-requiring GDM in UMMC, Abinash Kaur Karam Singh
  15. (2014) the effectiveness of cgm in insulin-requiring gestational diabetes: a randomized trial, sharmila sunita paramasivam
  16. (2014) Genetic Markers In Uncontrolled Type 2 Diabetes Mellitus Patients With Obesity, NOR BAHIRAH BINTI KASIM
  17. (2012) Prevalence of Vitamin D inadequacy in Malaysian PMO women living in the tropics, Sharifah Fara WM Hatta
  18. (2012) Clinical Predictors Of Insulin Resistance And Glycaemic Control In Type 2 Diabetes Mellitus (T2DM) With Coronary Heart Disease (CHD), SHARIFAH INTAN QHADIJAH JAMALOLIL BT SYED IKMAL HASHIM
  19. (2012) Bone turnover markers, Vitamin D status and endocrinopathy among transfusion dependent thalassemia patients in a tertiary hospital in Malaysia, Fatimah Zaherah (University of Malaya (UM))
  20. (2011) Urine Bisphenol A Levels in Patients with Diabetes Mellitus and Metabolic Syndrome, Luqman Ibrahim
  21. (2011) Prevalence of metabolic syndrome and subclinical atherosclerosis in urban Malaysian HIV-infected patients, Muhamad Yazli Yuhana
  22. (2011) Maintenance dose of Vitamin D required for sufficiency in Chinese postmenopausal women living in the tropics, Yogeswari Venugopal (000000269)
  23. (2011) FACTORS INFLUENCING POOR GLYCAEMIC CONTROL IN PEOPLE WITH TYPE 2 DIABETES USING INSULIN: A QUALITATIVE STUDY, TONG WEN TING
  24. (2011) Clinical Supervision Endocrine Subspecialty Training, Rohaya Abdul Razak (M0100401)
  25. (2010) Thesis:Pituitary dysfunction among nasopharyngeal cancer survivors in PPUM, Nor Afidah Karim
  26. (2010) Thesis:Pituitary dysfunction among nasopharyngeal cancer survivors in PPUM, Jeyakantha Ratnasingam
  27. (2010) Clinical Supervision, Ijaz Hallaj Rahmatullah
  28. (2010) Clinical Supervision, Diana Ng Leh Ching
  29. (2010) Clinical Supervision, Chai Chee Shee
  30. (2010) Clinical Supervision, Ahmed Rashid
Under Graduate Students
  1. (2023) Final Year Project, Marisa Khatijah binti Borhan
  2. (2022) endocrine subspecialty fellowship
  3. (2022) A pilot observational prospective study comparing Glycated albumin and Glycated haemoglobin as a measure of glycaemic control in Malaysian mothers with diabetes in pregnancy: interim analysis
  4. (2022) Accuracy of Point of Care HBA1C testing in Malaysian Gravid mothers
  5. (2012) The Prevalence and Associated Factors of Neuropathic Pain in Multi-Ethnic Malaysian Patients with Diabetes Mellitus
  6. (2012) Prevalence of hypoglycemia amongst diabetic patients undergoing chronic hemodialysis

TEACHING

Master
  1. (2022) MMed - Master in Internal Medicine
  2. (2021) NA- - Master of Internal Medicine(Mmed)
  3. (2012) Endocrinology - Masters of Medicine
  4. (2012) Endocrinology - Masters of Primary Care Medicine, Masters of Ophthalmology
  5. (2012) W - Masters of Internal Medicine
  6. (2011) Endocrinology - Masters of Medicine
  7. (2007) Endocrinology -Masters of Medicine
  8. (2006) Endocrinology - Masters of Anaesthesiology
  9. (2006) Endocrinology -Masters of Medicine
  10. (2005) Endocrinology - Masters of Anaesthesiology
  11. (2005) Endocrinology -Masters of Medicine
  12. (2004) Endocrinology - Masters of Anaesthesiology
  13. (2004) Endocrinology -Masters of Medicine
Bachelor
  1. (2022) UMMP - Ummp Stage 2 Cohort 2020
  2. (2022) UMMP - Ummp Stage 3.1 Cohort 2019
  3. (2022) UMMP - Ummp Stage 3.3 Cohort 2017
  4. (2021) NA- - Ummp Stg 3.1
  5. (2021) NA- - Ummp Stg 3.3
  6. (2021) MIA 2001 - Universiti Malaya Medical Programme (Ummp)
  7. (2021) (-) - University Malaya Medical Programme Stg 1
  8. (2013) W - Endocrinology-MBBS
  9. (2013) W - Internal Medicine & Endocrinology_mbbs
  10. (2012) Endocrinology - MBBS
  11. (2012) Endocrinology -MBBS
  12. (2012) Internal Medicine - MBBS
  13. (2011) Endocrinology - MBBS
  14. (2007) Internal Medicine - Dental Surgery
  15. (2007) Internal Medicine- Dental Surgery
  16. (2006) Endocrinology/Internal Medicine- MBBS
  17. (2006) Endocrinology - MBBS
  18. (2006) Internal Medicine - Dental Surgery
  19. (2005) Endocrinology/ Internal Medicine - Dental Surgery
  20. (2005) Endocrinology/Internal Medicine- MBBS
  21. (2005) Endocrinology -MBBS
  22. (2005) Internal Medicine -Dental Surgery
  23. (2004) Endocrinology - Dental Surgery
  24. (2004) Endocrinology/Internal Medicine- MBBS
  25. (2004) Endocrinology - MBBS
Others
  1. (2012) ADDE8002 - Advanced Diploma in Diabetes Education:Management of Diabetes

SOCIAL RESPONSIBILITY ACTIVITIES

  • Member of Mems Research Grant Application Subcommittee, (17 Nov 2020 - 17 Dec 2021)
  • Member of National Steering Committee for Endocrine Subspecialty Training, (01 Jan 2020 - 31 Dec 2020)
  • Member of National Committee for Update of The Cpg On Management of Obesity, (12 Mar 2019 - 31 Dec 2020)
  • Public Talk On 'Hormones and The Transgender Woman', (19 Oct 2018 - 19 Oct 2018)
  • Cme for General Practitioners,1st Global Manipal Alumni Health, Science & Technology Convention, (08 Aug 2014 - 08 Aug 2014)
  • Public Lecture - Management of Insulin Therapy,Organized by Pdm, (29 Jan 2011 - 29 Jan 2011)
  • Invited Speaker - Lecture 'Treating to Target", Mma Wilayah Persekutuan Primary Care Symposium 2006, (26 Aug 2006 - 27 Aug 2006)
  • Facilitator -Insulin-Diabetes Camp, Ulu Yam, Selangor - Organized by Pdm(Malaysian Diabetes Association)and Ppum, (20 Aug 2005 - 22 Aug 2005)
  • 2nd National Diabetes Seminar 2005 - Invited Speaker, Lecture On "Practical Aspects of Diabetes Monitoring", (15 Jul 2005 - 17 Jul 2005)
  • Seminar Diabetes Ppum - Lecture On "Glucose Monitoring", (28 Jun 2005 - 28 Jun 2005)
  • Facilitator, National Diabetes Insulin Camp, Melaka - Co-Organized by Kementerian Kesihatan Malaysia, Persatuan Diabetis Malaysia, Ppum, (25 Nov 2004 - 28 Nov 2004)
  • Public Lecture - Ford Motor Co. Family Day, 2004, (01 Sep 2004 - 01 Sep 2004)
  • Invited Speaker - Addison's Disease, Postgraduate Course Organized by Uitm, (06 Jun 2004 - 06 Jun 2004)
  • Facilitator, National Diabetes Insulin Camp, (30 May 2004 - 02 Jun 2004)
  • Public Talk - Persatuan Diabetis Malaysia, (05 Apr 2004 - 05 Apr 2004)
  • Program Pendidikan Diabetis Untuk Staf Ppum - Lecture On "Diabetes Management and Medications", (11 Mar 2003 - 11 Mar 2003)
  • Facilitator/Invited Speaker - Diabetes Educator Course/1st Diabetic Camp Organized by Pdm At Similajau National Park, Bintulu, Sarawak, (24 Oct 2002 - 27 Oct 2002)
  • Invited Speaker - "National Advanced Diabetes Educator" Workshop, (18 Oct 2002 - 20 Oct 2002)
  • Symposium On Diabetes Organized by Pdm Miri Branch- Invited Speaker, (20 Apr 2002 - 21 Apr 2002)