PERSONAL DETAIL


DR. SHAMSUL BIN MOHD ZAIN

Department of Pharmacology
Faculty of Medicine
 
  shamsul@um.edu.my
 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, W.Persekutuan Kuala Lumpur, Malaysia
 
ResearcherID Link
  http://www.researcherid.com/rid/N-6995-2013

ACADEMIC QUALIFICATION
(Qualification), (Institution).



PROFESSIONAL
(Organisation), (Role), (Year), (Level).


  • Golden-Helix Symposium 2015, Scientific Chairman, 2015 to 2015, (International)
  • Public Health Genomics, Guess Editor, Editorial Board, 2015 to 2015, (International)
  • Faculty of Medicine Research Week, Panel Member, 2015 to 2015, (University)
  • South East Asian Pharmacogenomics Research Network, International Board Member, 2017, (International)
  • University of Malaya-University of Edinburgh Research Symposium on Metabolic Syndrome, Organising Committee Member, 2017 to 2017, (International)
  • Malaysian Society of Pharmacology and Physiology, Member, 2018, (National)

ADMINISTRATIVE DUTIES
(Role), (Level), (Start date),(End Date).


  • Coordinator Journal Club, Faculty, 01/06/2018 to 31/12/2019 (Postgraduates Journal Club)
  • Academic advisor, Faculty, 20/02/2018 to 31/12/2019 (Postgraduates Journal Club)
  • Coordinator of Pharmacology course for Pharmacy programme, Faculty, 05/10/2016 to 31/12/2019 (Course Coordinator for Pharmacology)

AREAS OF EXPERTISE
(Area).


  • Molecular Genetics
  • Experimental Design and Analysis (Biostatistics and Meta-analysis)
  • Gastroenterology (Non-alcoholic Fatty Liver Disease)
  • Pharmaco-Genomic


RECENT SELECTED PUBLICATIONS
(Publication).


Article in Academic Journals

2019
  • Sivapalan V, Zain SM, Shengnan J, Chan SL, Liu J, Mohamed Z, Mohamed R. Impact of Nitric Oxide Synthase 2 Gene Variant on Risk of Anti-Tuberculosis Drug Induced Liver Injury. Sains Malaysiana. 2019; Accepted for publication (ISI-Indexed)
  • Chumnumwat S, Lu Z.H, Sukasem C, Winther MD, Capule FR, Abdul Hamid AA, Bhandari B, Chaikledkaew U, Chanhom N, Chantarangsu S, Charoenyingwattana A, Hang TT, Hlaing TM, Htun KS, Jittikoon J, Le L, Mahasirimongkol S, Mohamed Noor DA, Shrestha J, Suwannoi L, Tragulpiankit P, Turongkaravee S, Wattanapokayakit S, Xangsayarath P, Yuliwulandari R, Zain SM, Chantratita W. South East Asian Pharmacogenomics Research Network (SEAPharm): Current Status and Perspectives. Public Health Genomics. 2019;22(3-4):132-139 (ISI-Indexed)

2018
  • Jamalpour S, Zain SM, Mosavat M, Mohamed Z, Omar SZ. A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes mellitus. Gene 2018; 650(18)34-40. (ISI-Indexed)

2017
  • Islam M, Mohamed EH, Esa E, Kamaluddin NR, Zain SM, Mat Yusoff Y, Assenov Y, Mohamed Z, Zakaria Z. Circulating cytokines and small molecules follow distinct expression patterns in acute myeloid leukaemia. British Journal of Cancer. 2017; 117(10):1551-1556. (ISI-Indexed)
  • Miyata-Nozaka Y, Zain SM, Taguchi M, Shigeyama M, Isobe T, Hanioka N: Carbamazepine 10,11-epoxidation in human liver microsomes: influence of the CYP3A5*3 polymorphism. Die Pharmazie 2017; doi: 10.1691/ph.2017.7754 (ISI-Indexed)
  • Prevathe Poniah, Shamsul Mohd Zain, Azad Hassan Abdul Razack, Shanggar Kuppusamy, Shankar Karuppayah, Hooi Sian Eng, Zahurin Mohamed: Genome-wide copy number analysis reveals candidate gene loci that confer susceptibility to high-grade prostate cancer. Urologic Oncology 05/2017;, DOI:10.1016/j.urolonc.2017.04.017 (ISI-Indexed)

2016
  • Nazree, NE, Mohamed, Z; Reynolds, GP; Zain, SM; Masiran, R, Sidi, H, Chong, LA , Hway, AY, Adlan, AS, Zainal, NZ.(2016) Association of brain-derived neurotrophic factor valine to methionine polymorphism with sexual dysfunction following selective serotonin reuptake inhibitor treatment in female patients with major depressive disorder. ASIA-PACIFIC PSYCHIATRY, 8(4): 260-268 DOI: 10.1111/appy.12210 (ISI-Indexed)
  • Lim CH, Zainal NZ, Kanagasundram S, Zain SM, Mohamed Z. Preliminary examination of microRNA expression profiling in bipolar disorder I patients during antipsychotic treatment. American Journal of Medical Genetics Part B Neuropsychiatric Genetics. 2016; 171(6):867-74. (ISI-Indexed)
  • Tan HL, Mohamed R, Mohamed Z, Zain SM. Phosphatidylethanolamine N-methyltransferase gene rs7946 polymorphism plays a role in risk of non- alcoholic fatty liver disease: Evidence from meta- analysis. Pharmacogenetics and Genomics. 2016; 26(2):88-95. (ISI-Indexed)

2015
  • Joyce-Tan SM*, Zain SM*, Abdul Sattar MZ, Abdullah NA. Renin-angiotensin system gene variants and type 2 diabetes mellitus: influence of angiotensinogen. Journal of Diabetes Research. 2015; Accepted for publication (Co-first author) (ISI-Indexed)
  • Langmia IM, Apalasamy YD, Omar SZ, Zain SM, Mohamed Z. Protein profiling of women with spontaneous preterm birth. Pharmacology. 2015;96(1-2):44-8 (ISI-Indexed)
  • Zain SM, Mohamed Z, Jalaludin MY, Fauzi F, Hamidi A, Zaharan NL. Comprehensive evaluation of the neuropeptide-y gene variants in risk of obesity: A case-control study and meta-analysis. Pharmacogenetics and Genomics. 2015;25(10):501-10 (ISI-Indexed)
  • Zain SM, Mohamed Z, Pirmohamed M, Tan HL, Alshawsh MA, Mahadeva S, Chan WK, Nik Mustapha NR, Mohamed R. Copy number variation in exportin-4 (XPO4) gene and its association with histological severity of non- alcoholic fatty liver disease. Scientific Reports. 2015; 5(13306).doi: 10.1038/srep13306. (ISI-Indexed)
  • Poniah P, Mohamed Z, Apalasamy YD, Zain SM, Kuppusamy S, Razack AHA. Genetic polymorphisms in the androgen metabolism pathway and risk of prostate cancer in low incidence Malaysian ethnic groups. Int J Clin Exp Med. 2015; 8(10): 19232-40. (ISI-Indexed)
  • Zain SM, Mohamed Z, Mohamed R. A common variant in the glucokinase regulatory gene rs780094 and risk of non- alcoholic fatty liver disease: A meta-analysis. J Gastroenterol Hepatol. 2015;30(1):21-7. (ISI-Indexed)

2014
  • Suthandiram S, Gan GG, Zain SM, Bee PC, Lian LH, Chang KM, Ong TC, Mohamed Z. Genetic polymorphisms in the one- carbon metabolism pathway genes and susceptibility to non-Hodgkin lymphoma. Tumour Biol 2014. Accepted for publication (ISI-Indexed)
  • Suthandiram S, Gan GG, Zain SM, Bee PC, Lian LH, Chang KM, Ong TC, Mohamed Z. Effect of polymorphisms within methotrexate pathway genes on methotrexate toxicity and plasma levels in adults with hematological malignancies. Pharmacogenomics. 2014;15(11):1470-94. (ISI-Indexed)
  • Lim CH, Zain SM, Reynolds GP, Zain MA, Roffeei SN, Zainal NZ, Kanagasundram S, Mohamed Z. Genetic association of LMAN2L gene in schizophrenia and bipolar disorder and its interaction with ANK3 gene polymorphism. Prog Neuropsychopharmacol Biol Psychiatry. 2014; Accepted for publication (ISI-Indexed)
  • Suthandiram S, Gan GG, Zain SM, Haerian BS, Bee PC, Lian LH, Chang KM, Ong TC, Mohamed Z. Polymorphisms in methylenetetrahydrofolate reductase gene and risk of non-Hodgkin lymphoma in a multi-ethnic population. J Hum Genet. 2014;59(5):280-7. (ISI-Indexed)
  • Zain SM, Mohamed R, Cooper DN, Razali R, Rampal S, Mahadeva S, Chan WK, Anwar A, Rosli NSM, Mahfudz AS, Cheah PL, Basu RC, Mohamed Z. Genome-wide analysis of copy number variation identifies candidate gene loci associated with the progression of non-alcoholic fatty liver disease. PloS ONE. 2014;9(4): e95604.doi:10.1371 (ISI-Indexed)

2013
  • Lye S-H, Chahil JK, Bagali P, Alex L, Vadivelu J, Ahmad WA, Chan SP, Thong MK, Zain SM, Mohamed R. (2013) Genetic polymorphisms in LDLR, APOB, PCSK9 and other lipid related genes associated with familial hypercholesterolemia in Malaysia. PLoS ONE 8(4): e60729. doi:10.1371/journal.pone.0060729 (ISI-Indexed)
  • Zain SM, Mohamed Z, Mahadeva S, Rampal S, Basu RC, Cheah PL, Agus S, Rosmawati Mohamed. Susceptibility and gene interaction study of the angiotensin II type 1 receptor (AGTR1) gene polymorphisms with non-alcoholic fatty liver disease in a multi-ethnic population. PLOS ONE 2013;8(3):e58538 (ISI-Indexed)
  • Zain SM, Mohamed Z, Mahadeva S, Cheah PL, Rampal S, Chin KF, Basu RC, Tan HL, Mohamed R. The impact of LEPR variants on risk of non-alcoholic fatty liver disease and its interaction with PNPLA3 variant. J Gastroenterol Hepatol ;28(5):873-9. (ISI-Indexed)
  • Tan HL*, Zain SM*, Mohamed R, Rampal S, Chin KF, Basu RC, Cheah PL, Mahadeva S, Mohamed Z . Association of glucokinase regulatory gene polymorphisms with risk and severity of non-alcoholic fatty liver disease: An interaction study with adiponutrin gene. J Gastroenterol 2013. DOI 10.1007/s00535-013-0850 (Co- First Authors) (ISI-Indexed)

2012
  • Zain SM, Mohamed R, Mahadeva S, Cheah PL, Rampal S, Basu RC, Mohamed Z. A multi-ethnic study of a PNPLA3 gene variant and its association with disease severity in non-alcoholic fatty liver disease. Hum Genet. 2012;131:1145-1152 (ISI-Indexed)

AREAS OF RESEARCH
(Project title), (Role), (From)-(Until), (Level), (Source).


  • Microrna-mrna Regulatory Relationship In Normal Karyotype Acute Myeloid Leukaemia Assessed By Clinical And Computational Data, Principal Investigator(PI), 2019 - 2020, Fundamental Research Grant Scheme (FRGS), (National)
  • Genetic Determinants Of Susceptibility And Severity In Non-alcoholic Fatty Liver Disease, Principal Investigator(PI), 2016 - 2019, Bantuan Kecil Penyelidikan (BKP), (National)
  • Antiproliferative and Chemopreventive Effects of Selected Polyphenols on Colorectal Cancer: in vitro and in vivo Studies, Consultant, 2015 - 2017, Geran Penyelidikan Universiti Malaya (UMRG) - AFR (Frontier Science), (University)
  • Pharmacogenomics Study Of Possible Anti-obesity Agent From Catha Edulis Plant Extract And Its Main Alkaloid Cathinone On Obese Animal Model, Consultant, 2013 - 2018, Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness), (University)

CONSULTATION PROJECT/CONSULTANCY
(Project title), (Role), (From)-(Until), (Organisation).


  • Exome sequencing, 2017-2017, Dr Azlina Anwar
  • Alemtuzumab meta-analysis, 2016-2016, UMMC Renal Group
  • Genetic analysis, 2016-2016, PhD Postgraduate Department of Pharmacy

AWARDS AND RECOGNITIONS
(Name of Award), (Awarding Institution), (Year Awarded), (Level).


  • Human Life Advancement Foundation Scholarship, Human Life Advancement Foundation, 2015, (International)
  • Thesis With Distinction, University of Malaya, 2013, (University)
  • Poster Award, 26th Scientific Meeting of Malaysian Society of Pharmacology & Physiology, 2012, (National)
  • Poster Award, Ninth Jsh Single Topic Conference "Nash 2010"- Tokyo, 2010, (International)

PRESENTATIONS
(Title), (Event), (Date Presented), (Organiser), (Level).


ORAL
  • HLA-DQB1*06 Is an Independent Predictor of Significant Fibrosis in Patients with Non-alcoholic Fatty Liver Disease, 31st Scientific Meeting Malaysian Society of Pharmacology & Physiology (MSPP), 2017-08-18 to 2017-08-19, USM, (National)
POSTER
  • Cytogenetically normal acute myeloid leukaemia (CN-AML) cancer-related pathway and its interaction assessed by human clinical and computational data, 32nd Scientific Meeting Malaysian Society of Pharmacology & Physiology , 2018-08-08 to 2018-08-09, Malaysian Society of Pharmacology & Physiology , (National)

EXPERT LINKAGES
(Linkages Description), (Organisation), (Year of Involvement), (Duration), (Level).


  • Research Collaboration, Dr Pung Yuh Fen, University of Nottingham, Malaysia, 2017, 40, (National)
  • Research Collaboration, 100 Phamacogene NGS, SEAPharm, 2017, 40, (International)

EXPERT/TECHNICAL CONTRIBUTIONS
(Activity), (Organisation), (Role), (From)-(Until), (Level).


  • Coordinator for The Biostatistics Workshop- Learn How to Analyse SNP and CNV using SPSS, Pharmacogenomics Laboratory, Coordinator, 2017-2017, (National)

EVALUATION ACTIVITIES
(Description), (Evaluation Activity),(Year).


  • Thesis Examiner for Final Year Project Biomedical Science MIC4005, Tay Yi Wen, Thesis ,  (2019 - 2019)
  • Thesis Examiner for Final Year Project Biomedical Science MIC4005, Fong Suh Kuan, Thesis ,  (2019 - 2019)
  • Reviewer of Manuscript ID GTMB-2019-0005 for Genetic Testing and Molecular Biomarkers, Article In Journal ,  (2019 - 2019)
  • Reviewer of Manuscript ID TBMK-2019-OR-0286 for Biomarkers, Article In Journal ,  (2019 - 2019)
  • Reviewer of Manuscript ID MGG3-2019-03-0245 for Molecular Genetics & Genomic Medicine, Article In Journal ,  (2019 - 2019)
  • Poster judge at the 33rd Malaysian Society of Pharmacology and Physiology 2019, Abstracts ,  (2019 - 2019)
  • Examiner for PhD Proposal Defence, Ting Choo Yuen, Phd Proposal Defence ,  (2018 - 2018)
  • Examiner for PhD Proposal Defence, Tong Kind Leng, MVA170018, Phd Proposal Defence ,  (2018 - 2018)
  • Examiner for Master Proposal Defence, Lim Jia Lun, MGN170019, Master Proposal Defence ,  (2018 - 2018)
  • Examiner for Master Proposal Defense, Adibah Sahmat, Master Proposal Defence ,  (2017 - 2017)
  • Examiner for PhD Proposal, Tong Kind Leng, Phd Proposal ,  (2017 - 2017)
  • Thesis Examiner for Final Year Project Biomedical Science MBEB4180, Foo Jia Ying, Thesis ,  (2017 - 2017)
  • Reviewer of Manuscript ID GTMB-2017-0148 for Genetic Testing and Molecular Biomarkers, Article In Journal ,  (2017 - 2017)
  • Examiner for Master Proposal Defense Dr Ruksana Raihan, Master Proposal Defence ,  (2016 - 2016)
  • Reviewer of Manuscript ID GTMB-2016-0047 for Genetic Testing and Molecular Biomarkers, Article In Journal ,  (2016 - 2016)

CONTRIBUTION TO SOCIETY
(Contribution To Society), (Level), (Start Date), (End Date).


  • Volunteer at Madrasah Darul Tahfiz Sri Al Ain, Kg Kubu Gajah, Sungai Buloh, (Community), 21/04/2018 until 21/04/2018
  • Facilitator in Let's Go to Mummie's Lab, (Community), 13/02/2018 until 13/02/2018
  • Volunteer at Pusat Jagaan Kanak-kanak Down Syndrome and Hyper Active, Bandar Bukit Tinggi 2, Klang, (Community), 27/01/2018 until 27/01/2018
  • Tunas Geliga Camp, (Community), 10/12/2017 until 10/12/2017

SUPERVISION


POST GRADUATE STUDENT
(Name of Degree), (Name of Candidates), (Title of Thesis), (Academic Session)

Ongoing
  • Master Degree, Ting Yi Wen, Clinical Outcomes and The Association with Genetic Determinants of Non-Alcoholic Fatty Liver Disease Patients, 2019/2020
  • Master Degree, Ariwibawa Kasmani Mohd Hashim, Proteomics and MicroRNA Profiling for Identification of Biomarkers in Acute Myeloid Leukemia (AML) Patients, 2017/2018
  • Doctoral Degree (phd), Yuka Nozaka, Pharmacogenetics of CYP3A5 on Antiepileptic Drugs Response and Its Pharmacokinetics, 2017/2018
  • Master Degree, Kevin Tey Wen Fei, STUDIES OF RISK FACTORS ASSOCIATED WITH PATIENT MORBIDITY IN HAEMATOPOIETIC STEM CELL TRANSPLANTATION, 2017/2018
  • Master Degree, Noor Atiqah Fakharuzi, Detection of Somatic Aberration in Acute Myeloid Leukemia with Normal Cytogenetics (CN-AML) in the Malaysian Patient, 2016/2017

Completed
  • Master Degree, Vishala Sivapalan, Pharmacogenomics of Anti-Tuberculosis Drug-Induced Liver Injury (AT-DILI) in Malaysia, 2018/2019
  • Doctoral Degree (phd), Tan Hwa Li, Molecular Biomarkers and Genetic Determinants of Non-alcoholic Fatty Liver Disease (NAFLD), 2018/2019

TEACHING
(Course Title), (Academic Session), (No of Student), (No of Contact Hours).


FIRST DEGREE
  • PHARMACOLOGY, 2017/2018(1), 49, 10
  • ADVANCED IN MEDICAL PHARMACOLOGY, 2017/2018, 5, 7
  • PHARMACOTHERAPY FOR GASTROINTESTINAL AND RESPIRATORY DISORDERS, 2017/2018(1), 32, 16
  • UMMP GASTROENTEROLOGY & NUTRITION BLOCK PBL, 2017/2018, 8, 9
  • UMMP HAEMATOLOGY BLOCK PBL, 2017/2018(1), 8, 9
  • PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2017/2018, 44, 12
  • PHARMACOTHERAPY FOR GASTROINTESTINAL AND RESPIRATORY DISORDERS, 2016/2017, 67, 9
  • PHARMACOLOGY, 2016/2017, 53, 9
  • CENTRAL NERVOUS SYSTEM & THERAPY, 2016/2017, 3, 2
  • PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2016/2017, 44, 9
  • PRINCIPLES OF DRUG ACTION & PERIPHERAL NERVOUS SYSTEM, 2015/2016, 6, 10
  • UMMP RESPIRATORY SCIENCES BLOCK, 2015/2016, 8, 10