Curriculum Vitae

DATUK PROF. DR. ROHANA BINTI YUSOF

Honorary Professor
  • Institute of Research Management and Services
  • rohana

AREAS OF EXPERTISE

  • MOLECULAR VIROLOGY-DENGUE VIRUS AND HUMAN PAPILLOMAVIRUS
  • MAJOR HISTOCOMPABILITY CLASS I GENE EXPRESSION
  • DENGUE VIRUS PROTEASE

ACADEMIC QUALIFICATION

  • PhD(Leeds University)(1993), (Biologi Molekul)
    Leeds University, Leeds, UK
  • MSc(Biochemistry)(1990), (Biochemistry)
    Universiti Malaya (UM)
  • sijil perguruan lepasan ijazah, (Biologi / Biokimia / Mikrobiologi / Kimia Organik)
    Maktab Perguruan Temenggong Ibrahim, J. Bahru
  • BSc(Biochemistry)(1984), (BIOKIMIA)
    Lancaster University, United Kingdom

ADMINISTRATIVE DUTIES

  • Deputy Vice-Chancellor (Student Affairs)
    08 Aug 2016 - 07 Aug 2018 (Deputy Vice-Chancellor (Student Affairs) Office, Deputy Vice-Chancellor (Student Affairs))
  • Commandant
    01 Nov 2010 - 01 Mar 2018 (National)
  • Deputy Vice-Chancellor (Student Affairs)
    08 Aug 2015 - 07 Aug 2016 (Deputy Vice-Chancellor (Student Affairs) Office, Deputy Vice-Chancellor (Student Affairs))
  • Board of Directors, Education Malaysia Global Services (EMGS)
    13 Apr 2012 - 08 Aug 2016 (National)
  • Commandant Kor SUKSIS
    01 Sep 2010 - 08 Aug 2016 (University Malaya)
  • Board of Directors, PharmaUji Sdn Bhd under UMHoldings
    03 Oct 2011 - 08 Aug 2016 (University Malaya)
  • Chairman of Students Welfare Fund (Tabung Kebajikan Pelajar)
    31 Aug 2010 - 08 Aug 2016 (University Malaya)
  • Committee Member University of Malaya Master Plan
    13 Feb 2014 - 07 Aug 2016 (University Malaya)
  • Board of Directors, Loke Yew Board of Trustees
    02 Aug 2010 - 01 Jul 2016 (National)
  • Deputy Vice-Chancellor (Student Affairs)
    08 Aug 2013 - 07 Aug 2015 (Deputy Vice-Chancellor (Student Affairs) Office, Deputy Vice-Chancellor (Student Affairs))
  • Director of Pusat Keusahawan Universiti Malaya (PUSMAL)
    03 Oct 2011 - 31 Jan 2014 (University Malaya)
  • Deputy Vice-Chancellor (Student Affairs)
    08 Aug 2010 - 07 Aug 2013 (Deputy Vice-Chancellor (Student Affairs) Office, Deputy Vice-Chancellor (Student Affairs))
  • Interview Board: Anugerah Tokoh Siswa
    01 Jan 2013 - 31 Dec 2013 (National)
  • Committee Member for University & University College Act (UUCA) Amendment Dec 2011
    01 Aug 2011 - 10 Oct 2012 (National)
  • Deputy Director AKEPT (Research and Innovation, Higher Education Leadership Academy)
    01 Jan 2008 - 31 Aug 2010 (National)
  • Ibnu Sina Residential College Quality Manager
    01 Jan 2003 - 31 Dec 2007 (University Malaya)
  • Principal of Ibnu Sina Residential College
    01 Jan 2003 - 31 Dec 2007 (University Malaya)
  • Advisor for Medicine Society (MedSoc) and Islamic Medical Students Society (PSIPUM)
    05 Sep 2005 - 31 Dec 2007 (University Malaya)
  • MBBS Coordinator phase - 1 in Faculty of Medicine
    11 Apr 2001 - 16 Apr 2003 (Department of Molecular Medicine, Faculty of Medicine)
  • Internal auditor Faculty of medicine
    07 Jun 2000 - 11 Sep 2002 (Department of Molecular Medicine, Faculty of Medicine)
  • Committee Action Plan
    03 Feb 2000 - 23 Jan 2002 (University Malaya)
  • College Secretary
    01 May 1997 - 18 Nov 1997 (University Malaya)
  • Resource Person for automated DNA sequencer in AMCAL Faculty of Science
    11 Apr 1995 - 12 Mar 1997 (University Malaya)

AWARD AND STEWARDSHIP

  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2017 (University)
  • PECIPTA 2013, Gold
    MOHE, 2013 (National)
  • BIOMALAYSIA 2012, Bronze
    MOSTI, 2012 (International)
  • DEGREE AWARDS
    SERI PADUKA BAGINDA YANG DI-PERTUAN AGONG TUANKU MIRZAN ZAINAL ABIDIN, 2011 (State)
  • Darjah Kebesaran Panglima Mahkota Wilayah
    Seri Paduka Yang Dipertuan Agong Tuanku Mirzan Zainal Abidin, 2011 (National)
  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2006 (University)
  • KHIDMAT SETIA 20 AWARD
    University of Malaya, 2006 (University)
  • Award for excellent service
    University Malaya, 2006 (University)
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2005 (University)
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2004 (University)
  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2003 (University)
  • Award for excellent service
    University Malaya, 2003 (University)
  • Award for excellent service
    University Malaya, 2002 (University)
  • Fulbright Malaysian scholar
    Malaysia- America commission on educational exchange (MACEE), 1998 (International)
  • Asian molecular biology organization fellowship
    Asian molecular biology organization, 1998 (International)
  • Japanese society for promotion of science fellowship
    Japanese society for promotion of science, 1997 (International)
  • Malaysian High Commisioners award for academic excellence
    Malaysian High commision,London, 1992 (National)

PUBLICATIONS

Article in Journal
  1. Abdulrahman, A.Y., Khazali, A.S., Teoh, T.C. Hussin A. Rothan, Rohana Yusof . Novel peptides inhibit Zika NS2B-NS3 serine protease and virus replication in human hepatic cell line. Int J Pept Res Ther (2019). https://doi.org/10.1007/s10989-019-09808-4
  2. Abdulrahman,A.Y.,Rothan,H.A.,Khazali.A.S.,Teoh, T.CH.,Daheer, A.M. and Yusof,R. (2019). Synthetic peptide optimization improves the inhibition of dengue NS2B-NS3 protease and dengue replication in vitro. Acta Virologica 63,278-285
  3. Hariono,M.,Bing choi,S, Roslim,RF.,Nawi,MS.,Tan,M.L,Kamarulzaman,E.E.,Mohamed,N., Yusof,R.,Othman,S., Abdul Rahman,N., Othman,R., and A.Wahab,H. (2019) Thiogunine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling.PLOS ONE
  4. Hussin A. Rothan, Fadhil Lafta Faraj, Teow Chong Teoh, Rohana Yusof (2019) Novel Quinazoline derivatives inhibited HCV Serine protease and viral replication in Huh-7 cells. doi: https://doi.org/10.1101/671313
  5. Mat Yasin, Z. A, Khazali, A. S, Ibrahim, F, Nor Rashid, N, Yusof, R (2019). Antioxidant and Enzyme Inhibitory Activities of Areca catechu, Boesenbergia rotunda, Piper betle and Orthosiphon aristatus for Potential Skin Anti-aging Properties. Current Topics in Nutraceutical Research. Vol. 17 Issue 3, p229-235. 7p.
  6. Rothan H, Abdulrahman AY, Khazali AS, Nor Rashid N, Teoh TC, Yusof R (2019). Carnosine exhibits significant antiviral activity against Dengue and Zika virus. Journal of Peptide ScienceVolume 25, Issue 8. https://doi.org/10.1002/psc.3196
  7. Rothan HA, Zhong Y, Sanborn MA, Teoh TC, Ruan J, Yusof R, Hang J, Henderson MJ, Fang S. Small molecule grp94 inhibitors block dengue and Zika virus replication. Antiviral Res. 2019 Nov;171:104590. doi: 10.1016/j.antiviral.2019.104590. Epub 2019 Aug 14
  8. Rothan, H.A., Ambikabothy, J., Ramasamy, T.S. Nor Rashid N, Yusof R. A Preliminary Study in Search of Potential Peptide Candidates for a Combinational Therapy with Cancer Chemotherapy Drug. Int J Pept Res Ther (2019) 25: 115-122. https://doi.org/10.1007/s10989-017-9646-9
  9. Abd Rahman.N.,Ibrahim.F.,Aeinehvand.M., Yusof.R., Madou. M (2018). A microfluidic Lab-on-a-disc for antioxidant activities in plant extracts. Micromachines 9(4),140
  10. Abdullah,A.A., Lee.Y.K., Chin.S.P., Lim.,S.K.Lee.V. Othman. R., Othman.S., Yusof.R., Rahman.N.A. (2018) Discovery of Dengue Virus Inhibitors. Current Medicinal chemistry
  11. Abdulrahman,M.A., Hariono.,M.,Yusof.R., Rahman.,N.A., Wahab., H.A., Tan.M.L. (2018) Development of a NS2B/NS3 protease inhibition assay using AlphaScreenR beads for screening of anti-dengue activities. Heliyon 4 (12), e01023
  12. Gan.C.S., Lim.S.K., Chee.C.F.,Yusof.R., Heh.C.H., Rahman.NA (2018) Sofosbuvir as treatment against dengue? Chemical biology and drug design. 91 (2) 448-455
  13. Tan.W.L., Lee.T.K.,Ho Y.F., Yusof. R., Rahman.N.A/, Karsani S.A. (2018) Comparative proteomics reveals that YK51, a 4-hydroxypanduratin-A analogue downregulates the expressions of proteins associated with dengue virus infection. PeerJ 5
  14. Amir-Hassan, A; Lee, VS; Baharuddin, A; Othman, S; Xu, YT; Huang, ML; Yusof, R; Abd Rahman, N; Othman, R 2017. Conformational and energy evaluations of novel peptides binding to dengue virus envelope protein. JOURNAL OF MOLECULAR GRAPHICS MODELLING
  15. Chye Sheng Gan, Pei Jean Lim, Muhammad Fazril Mohamad Razif, Rohana Yusof and Shatrah Othman. 2017. Subversion of immunoproteasome subunits expression on dengue virus serotype 2 infected HepG2 cells. Rev Soc Bras Med Trop. 50(1), 1-5
  16. Gan, C.S., Lee, Y.K., Heh, C.H., Rahman, N.A., Yusof, R., Othman, S. (2017) The synthetic molecules YK51 and YK73 attenuate replication of dengue virus serotype 2. Tropical Biomedicine, 34 (2): 270-283.
  17. Hussin A. Rothan, Elham Amini, Fadihl Faraj, Mojtaba Golpich, Teow Chong Teoh, Khadijeh Gholami, and Rohana Yusof (2017) NMDA receptor antagonism with novel indolyl, 2-(1,1-Dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-malonaldehyde, reduces seizures duration in a rat model of epilepsy. Scientific Reports (Accepted).
  18. Hussin A. Rothan, Suhaeb A. Mahmod, Ivan Djordjevic, Rohana Yusof, Mojtaba Golpich, and Simmrat Snigh (2016). Hussin A. Rothan, Suhaeb A. Mahmod, Ivan Djordjevic, Rohana Yusof, Mojtaba Golpich, and Simmrat Snigh (2016). Polycaprolactone triol-citrate scaffolds enriched with human platelet releasates promote chondrogenic phenotype and cartilage extracellular matrix formation. Tissue Engineering and Regenerative Medicine DOI: 10.1007/s13770-017-0023-8.
  19. Mudiana M., Y. K. Lee, N. A. Rahman, R. Yusof (2017) Synthesized flavanoid-derived ligand reduced dengue virus type-2 replication in vitro, Asian Pacific Journal of Tropical Biomedicine, 7(2): 91-95
  20. Rufaidah Othman, Rozana Othman, Nagasundara Ramanan Ramakrishnan, Noorsaadah Abd Rahman, Rohana Yusof, Saiful Anuar Karsani. (2017). Molecular Docking Studies of Selected Medicinal Drugs as Dengue Virus-2 Protease Inhibitors. Sains Malaysiana, 46(10), 1865-1875.
  21. Suhaeb A. Mahmod, Simmrat Snigh, Ivan Djordjevic, Rohana Yusof, Thamil Selvee Ramasamy and Hussin A. Rothan (2016). Phytoestrogen (daidzein) promotes chondrogenic differentiation and extracellular matrix formation in 2D and 3D culture environments. Tissue Engineering and Regenerative Medicine DOI: 10.1007/s13770-016-0004-3.
  22. Yasin, ZAM., Ibrahim, F., Rashid, NN., Razif, MFM., Yusof, R., 2017, The Importance of Some Plant Extracts as Skin Anti-aging Resources: A Review, Curr Pharm Biotechnol.18(11):864-876.
  23. Ammar Y. Abdulrahman, Hussin A. Rothan, Nurshamimi N. et al., (2016). Identification of Peptide Leads to Inhibit Hepatitis C Virus: Inhibitory Effect of Plectasin Peptide Against Hepatitis C Serine Protease. International Journal of Peptide Research and Therapeutics, 1-8.
  24. Hussin A. Rothan, Hirbod Bahrani, Ammar Y. Abdulrahman , Zulqarnain Mohamed,Teow Chong Teoh, Shatrah Othman, Nurshamimi Nor Rashid ,Noorsaadah A. Rahman, Rohana Yusof. 2016. Mefenamic acid in combination with ribavirin shows significant effects in reducing chikungunya virus infection in vitro and in vivo. Antiviral Research. 2016 Jan 18;127:50-56. doi: 10.1016/j.antiviral.2016.01.006. (ISI-Cited Publication)(IF 4.9)
  25. Lim, S., Othman, R., Yusof, R., & Heh, C. (2016). Rational drug discovery of HCV helicase inhibitor: Improved docking accuracy with multiple seedings of Autodock Vina and in situ minimization. Curr Comput Aided Drug Des 2016 Nov 30.
  26. Nor Rashid, N., Yong, Z.L., Yusof, R. et al. HPV 16E7 and 48E7 proteins use different mechanisms to target p130 to overcome cell cycle block. Virol J 13, 2 (2016) doi:10.1186/s12985-015-0460-8
  27. Pouya Hassandarvish, Hussin A. Rothan , Sahar Rezaei, Rohana Yusof, Sazaly Abubakar, and Keivan Zandi (2016) In Silico Study on Baicalein and Baicalin as Inhibitors of Dengue Virus Replication. Royal Society of Chemistry Advances, DOI: 10.1039/C6RA00817H (ISI-Cited Publication)
  28. S. Othman, C. S. Gan, N. Abd Rahman, V. S. Lee and R. Yusof. 2016 Alteration of cell membrane constituents by dengue virus for successive evasion of immune response. FEBS Journal 283 (Suppl 1) 57 DOI:10:10.1111/febs.13807
  29. Bashar Yafouz, Nahrizul Adib Kadri, Hussin A. Rothan, Rohana Yusof and Fatimah Ibrahim (2015) Discriminating Dengue-Infected Hepatic Cells (WRL-68) Using Dielectrophoresis. Electrophoresis (Accepted).
  30. C.S. Gan, Y.K. Lee, R. Yusof, S. Othman. (2015) Targeting Non-Structural 3 Protein of Dengue Virus Type 2 in Development of Antiviral Therapy: Bioactivity of Ethyl (1-Tert-Butoxycarbonyl-2-Butyl-4-Phenyl)-Piperidinyl-3-Carboxylate. Public Health Genomics 2015;18(suppl 1):1 51 DOI: 10.1159/000381430
  31. Chye Sheng Gan, Rohana Yusof and Shatrah Othman. 2015. Different serotypes of dengue virus differently regulate the expression of host cell antigen processing machinery. Acta Tropica, 149: 8-14
  32. Elham Farahmand, Fatimah Ibrahim, Samira Hosseini, Hussin A. Rothan, Rohana Yusof, Leo H. Koole, Ivan Djordjevic (2015)A novel approach for application of nylon membranes in the biosensing domain. Applied surface science DOI:http://dx.doi.org/doi:10.1016/j.apsusc.2015.07.004
  33. Hussin A. Rothan, Hirbod Bahrani, Zulqarnain Mohamed, Teow Chong Teoh, Esaki M. Shankar, Noorsaadah A. Rahman, and Rohana Yusof (2015) A Combination of Doxycycline and Ribavirin Alleviated Chikungunya Infection. PLOS ONE DOI: 10.1371/journal.pone.0126360(ISI-Cited Publication)
  34. Hussin A. Rothan, Rohana Yusof (2015) Scalable production of recombinant membrane active peptides and its potential as a complementary adjunct to conventional chemotherapeutics. PLOS ONE 10.1371/journal.pone.0139248(ISI-Cited Publication)
  35. Krishnamurthy Narasimha Rao, Anirudha Lakshminarasimhan, Sarah Joseph, Swathi U. Lekshmi, Lau Ming‐Seong, Mohammed Takhi, Kandepu Sreenivas, Sheila Nathan, Rohana Yusof, Noorsaadah Abd. Rahman, Murali Ramachandra, Thomas Antony, Hosahalli Subramanya. AFN-1252 is a potent inhibitor of Enoyl-ACP reductase from Burkholderia pseudomallei - Crystal structure, Mode of action and biological activity. Protein Sci. 2015 Feb 2. doi: 10.1002/pro.2655
  36. Mohammad Mahdi Aeinehvand, Fatimah Ibrahim, Sulaiman Wadi Harun, Amin Kazemzadeh, Hussin A. Rothan, Rohana Yusof and Marc J Madou. Reversible Thermo-Pneumatic Valves on Centrifugal Microfluidic Platforms. Lab Chip, 2015,DOI: 10.1039/C5LC00634A . (IF = 6.1) (ISI-Cited Publication)
  37. Samira Hosseini, Fatimah Ibrahim, Hussin A. Rothan, Rohana Yusof, Cees van der Marel, Ivan Djordjevic, Leo H. Koole (2015)Aging effect and antibody immobilization on COOH exposed surfaces designed for dengue virus detection. Biochemical Engineering Journal doi:10.1016/j.bej.2015.04.001 (ISI-Cited Publication)
  38. Samira Hosseini, Mohammad M. Aeinehvand, Shah M. Uddin, Abderazak Benzina, Hussin A. Rothan, Rohana Yusof, Leo H. Koole, Marc J. Madou, Ivan Djordjevic, and Fatimah Ibrahim1 (2015) Microsphere integrated microfluidic disk: synergy of two techniques for rapid and ultrasensitive dengue detection. Nature scientific reports (Accepted) (ISI-Cited Publication)
  39. Samira Hosseinia, Pedram Azaric,Elham Farahmanda, Seng N. Ganc,Hussin A. Rothan,Rohana Yusof,Leo H. Koolea,Ivan Djordjevica, Fatimah Ibrahima (2015) Polymethacrylate coated electrospun PHB Fibers: An exquisite outlook for fabrication of paper-based Biosensors. Biosensors and Bioelectroncs, doi:10.1016/j.bios.2015.02.034 (IF, 6.25).
  40. Wisam Al-Faqheri, Fatimah Ibrahim, Tzer Hwai Gilbert Thio, Norulain Bahari, Hamzah Arof, Hussin A. Rothan, Rohana Yusof, Marc Madou, Development of Passive Liquid Valve (PLV) Utilizing a Pressure Equilibrium Phenomenon on the Centrifugal Microfluidic Platform Sensors 2015, 15, 4658-4676; doi:10.3390/s150304658(Q1, JCR 2012) (ISI-Cited Publication)
  41. Zeimaran E, Pourshahrestani S, Djordjevic I, Pingguan-Murphy B, Kadri NA, Rothan HA, Yusof R, Towler MR. Fabrication and characterization of poly (octanediol citrate)/Gallium-containing bioglass microcomposite scaffolds. Journal of Materials Science. (Q1, JCR 2013) DOI 10.1007/s10853-014-8782-2 (ISI-Cited Publication)
  42. Aida Baharuddin, Asfarina Amir Hassan, Rozana Othman, Yongtao Xu, Meilan Huang, Bimo Ario Tejo, Rohana Yusof, Noorsaadah Abdul Rahman and Shatrah Othman. 2014. Dengue Envelope Domain III-Peptide Binding Analysis via Tryptophan Fluorescence Quenching Assay. Chemical and Pharmaceutical Bulletin (Accepted) (ISI/SCOPUS Cited Publication)
  43. Hussin A. Rothan, Hirbod Bahrani, Noorsaadah Abd Rahman, and Rohana Yusof (2014)Identification of Natural Antimicrobial Agents to Treat Dengue Infection: In Vitro Analysis of Latarcin Peptide Activity against Dengue Virus. BMC Microbiology 14:140 doi:10.1186/1471-2180-14-140
  44. Hussin A. Rothan, Hirbod Bahrani, Noorsaadah Abd Rahman, and Rohana Yusof (2014)Inhibitory effects of a peptide fusion protein (Latarcin-PAP1-Thanatin) against chikungunya virus replication in vitro. Antiviral Research DOI: 10.1016/j.antiviral.2014.05.019(ISI-Cited Publication)
  45. Hussin A. Rothan, Ivan Djordjevic, Hirbod Bahrani, Fatimah Ibrahim, Noorsaadah Abd Rahmanh and Rohana Yusof(2014)Three-Dimensional culture environment increases the efficacy of platelet rich plasma releasate in prompting skin fibroblast differentiation and extracellular matrix formation. International Journal of Medical Sciences. 11(10):1029-1038. doi:10.7150/ijms.8895
  46. Hussin A. Rothan, Zulqarnain Mohamed, Ammar Y. Abdulrahman, Eng Chong Tan, Noorsaadah Abd Rahman and Rohana Yusof (2014)Screening of antiviral activities in medicinal plants extracts against dengue virus using dengue NS2B-NS3 protease assay.Tropical Biomedicine 31(2): 286 296.
  47. Hussin A. Rothan, Zulqarnain Mohamed, Noorsaadah Abd Rahman and RohanaYusof (2014) Fusion of protegrin-1 and Plectasin to MAP30 shows significant inhibition activity against dengue virus replication. PLOS ONE doi10.1371/journal.pone.0094561. (ISI-Cited Publication)
  48. Mohamed Takhi, Kandepu Sreenivas, Chandrashekar K. Reddy, Mahadari Munikumar, Kolakota Praveena, Pabolu Sudheer, Bandaru N.V.M. Rao, Gollamudi Ramakanth, Jampala Sivaranjani, Shardaprasad Mulik, [......], Rentala Pallavi, Anirudha Lakshminarasimhan, Sunil K. Panigrahi, Thomas Antony, Iskandar Abdullah, Yean K. Lee, Murali Ramachandra, Rohana Yusof, Noorsaadah A. Rahman, Hosahalli Subramanya. 2014 Discovery of azetidine based ene-amides as potent bacterial enoyl ACP reductase (FabI) inhibitors. European Journal of Medicinal Chemistry,84:382 394.
  49. Mohammad Mahdi Aeinehvand, Fatimah Ibrahim,Sulaiman Wadi Harun, Ivan Djordjevic,Samira Hosseini, Hussin A. Rothan ,Rohana Yusof and Marc J. Madou (2014) Biosensing Enhancement of Dengue Virus Using Microballoon Mixers on Centrifugal Microfluidic Platforms (Accepted) Biosensors and Bioelectronics (ISI-Cited Publication)
  50. S Othman, CS Gan, R Othman, R Yusof, NA Rahman. 2014. Modulation of the antigen processing machinery by dengue virus. International Journal of Infectious Diseases 21, 197
  51. Samira Hosseini, Fatimah Ibrahim, Ivan Djordjevic, Hussin A. Rothan, Rohana Yusof, Cees van der Marel, Abderazak Benzina, Leo H. Koole Synthesis and characterization of methacrylic microspheres for biomolecular recognition: Ultrasensitive biosensor for dengue virus detection. 2014, European Polymer Journal (Accepted) (ISI-Cited Publication)
  52. Samira Hosseini, Fatimah Ibrahim, Ivan Djordjevic, Hussin A. Rothan, Rohana Yusof,[...] (2014) Synthesis and Processing of ELISA Polymer Substitute: the Influence of Surface Chemistry and Morphology on Detection Sensitivity (Accepted) Applied Surface Science (ISI-Cited Publication)
  53. Aida Baharuddin, Asfarina Amir Hassan, Gan Chye Sheng, Shah Bakhtiar Nasir, Shatrah Othman,Rohana Yusof, Rozana Othman and Noorsaadah Abdul Rahman. 2013. Current approaches in antiviral drug discovery against the flaviviridae family. Special issue of current pharmaceutical design: rational design of antiviral compounds
  54. Hussin A. Rothan , Pottayil G Sasikumar , Ketha Amarnadh Reddy, Noorsaadah Abd Rahman and Rohana Yusof (2013) In vitro characterization of novel protegrin-1 analogues against neoplastic cells. Journal of peptide research and theraputics, DOI: 10.1007/s10989-013-9388-2.
  55. Hussin A. Rothan , Pottayil G Sasikumar , Ketha Amarnadh Reddy, Noorsaadah Abd Rahman and Rohana Yusof.2013 Anticancer Activity Of Novel Cell-Penetrating Peptides Against Breast Carcinoma Cells. Asia-Pacific Journal of Molecular Medicine 2013, 3 (SUPP 1)
  56. Hussin A. Rothan, Zulqarnain Mohamed, Noorsaadah Abd Rahman and RohanaYusof (2013) Anti-viral cationic peptides as a strategy for innovation in global health therapeutics for dengue virus: High yield production of the biologically active recombinant plectasin peptide. OMICS A Journal of Integrative Biology, Vol 17: DOI: 10.1089/omi.2013.0056.
  57. Hussin A. Rothan, Michael J. C. Buckle, Ammar Y. Abdulrahman, Noorsaadah Abd Rahman and RohanaYusof (2013) Study the antiviral activity of some derivatives of tetracycline and non-steroid anti inflammatory drugs towards dengue virus. Tropical Biomedicine 30(4): 681 690.
  58. Hussin A. Rothan, Zulqarnain Mohamed, Noorsaadah Abd Rahman, RohanaYusof (2013) Inhibitory effect of doxycycline against dengue virus replication in vitro. Archives virology, DOI: 10.1007/s00705-013-1880-7.
  59. Eng Chong Tan, Yean Kee Lee, Chin Fei Chee, Choon Han Heh, Sher Ming Wong, Christina Li Ping Thio, Gen Teck Foo, Norzulaani Khalid, Noorsaadah Abd Rahman, Saiful Anuar Karsani, Shatrah Othman, Rozana Othman and Rohana Yusof. 2012. Boesenbergia rotunda: From ethnomedicine to drug discovery. Evidence-Based Complementary and Alternative Medicine (Accepted) (ISI/SCOPUS Cited Publication)
  60. Hussin A. Rothan , HC Han, TS Ramasamy, S Othman, NA Rahman, Rohana Yusof. (2012) Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1. BMC Infectious Diseases 2012 Nov 21; 12(1):314.
  61. Hussin A. Rothan, Ammar Y. Abdulrahman, Pottayil G. Sasikumer, Shatrah Othman, Noorsaadah Abd Rahman, and Rohana Yusof. 2012.Protegrin-1 Inhibits Dengue NS2B- NS3 Serine Protease and Viral Replication in MK2 Cells.Journal of Biomedicine and Biotechnology Volume 2012 (2012), Article ID 251482, 6 pagesdoi:10.1155/2012/251482
  62. Neni Frimayanti,Sharifuddin M.Zain,Vannajan Sanghiran Lee,Habibah A.Wahab,Rohana Yusof and Noorsaadah Abd Rahman. 2012. Fragment -based molecular design of new competitive dengue Den2 NS2B/NS3 inhibitors from the components of Fingerroot (Boesenbergia Rotunda)In Silico Biology 11 29-37
  63. Shatrah Othman, Noorsaadah Abdul Rahman & Rohana Yusof. 2012. Induction of MHC class I HLA-A2 promoter by dengue virus occur at the NFkB binding domain of the Class I regulatory complex. Virus Research 163:238-245.
  64. Tan Eng-Chong, Lee Yean-Kee, Chee Chin-Fei, Heh Choon- Han, Wong Sher-Ming, Christina Thio Li-Ping, Foo Gen- Teck, Norzulaani Khalid, Noorsaadah Abd Rahman, Saiful Anuar Karsani, Shatrah Othman, Rozana Othman and Rohana Yusof. Boesenbergia rotunda : From Ethnomedicine to Drug Discovery. Evidence-Based Complementary and Alternative Medicine. Volume 2012, Article ID 473637, doi:10.1155/2012/473637
  65. Nurshamimi Nor Rashid, Rohana Yusof & Roger J.Watson.2011.Disruption of repressive p130-DREAM complexes by human papillomavirus E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer.Journal of General Virology 92:2620-2627.
  66. Tan Eng Chong,Foo Gen Teck, Wong Sher Ming, Noorsaadah Abd Rahman, Norzulaani Khalid, Saiful Anuar Karsani, Shatrah Othman & Rohana Yusof. 2011. Optimization of two-dimensional gel electrophoresis protocols for Boesenbergia rotunda in vitro suspension culture. Journal of Medicinal Plants Research Vol. 5(16): 3777- 3780.
  67. Antiviral actions of flavanoid-derived compounds on dengue virus type-2 , Mudiana Muhamad, Lee Yean Kee, Noorsaadah Abd. Rahman and Rohana Yusof, International Journal of Biological Sciences, 2010, 6(3), 294-302
  68. Shatrah Othman, Noorsaadah A. Rahman and Rohana Yusof. 2010. All Serotypes of Dengue Virus Induce HLA-A2 MHC Class I Promoter Activity in Human Liver Cells. Transactions of the Royal Society of Tropical Medicine and Hygiene,104:806-808
  69. Ravindran Thayan, Tan Lian Huat, Lucy Lum Chai See, Nor Shahidah Khairullah, Rohana Yusof and Shamala Devi. (2009):P Differential Expression of Aldolase, Alpha tubulin and thioredoxin peroxidase in peripheral blood mononuclear cells from Dengue fever and Dengue Hemorrhagic Fever patients. Southeast Asian J Tropical Medical Public Health. 2009; 40 (1):56-65
  70. Ravindran Thayan,Tan Lian Huat, Lucy Lum Chai See, Christina Tan Phoay Lay, Nor Shahidah, Rohana Yusof and Shamala Devi. 2007. The use of two-dimension electrophoresis to identify serum biomarkers from patients with dengue haemorrhagic fever. Transactions of the Royal Society for Tropical Medicine and Hygience 2009 103(4):413-9
  71. Rozana Othman, Tan Siew Kiat, Rohana Yusof, Habibah Abd. Wahab, Noorsaadah Abd. Rahman.2008. Docking of Non-competitive Inhibitors into Dengue Virus Type 2 Protease: Understanding the Interactions with Allosteric Binding Sites. Journal of Chemical Information and Modeling, 48,1582-1591
  72. Habibah Abd. Wahab, Rohana Yusof and Noorsaadah Abd. Rahman. 2007. A Search for Vaccines and Therapeutics for Dengue: A Review, Current Computer Aided Drug Design on Antiviral Agents and Emerging Diseases (Part I)3(2),101-112
  73. Lee Yean Kee, Tan Siew Kiat, Habibah Abdul Wahab, Rohana Yusof and Noorsaadah Abd. Rahman. 2007. Non-substrate Based Inhibitors of Dengue Virus Serine Protease: A Molecular Docking Approach to Study Binding Interactions between Protease and Inhibitors. Asia Pacific J. Mol Biol. Biotechnol., 15(2), 53-59
  74. Rozana Othman, Habibah Abdul Wahab, Rohana Yusof and Noorsaadah Abd Rahman. 2007. In silico analysis of one- dimensional secondary structure of Dengue virus type 2 NS2B/NS3 protease complex from prediction methods against crystal structure. In Silico Biology 7(2), 0022,
  75. Doustjalali, S.R., Yusof, R., Govindasamy, G.K., Bustam, A.Z., Pillay, B. and Hashim, O.H. (2006) Patients with nasopharyngeal carcinoma demonstrate enhanced serum and tissue ceruloplasmin expression, Journal of Medical Investigation, 53, 20-28.
  76. Inhibitory Activity of Cyclohexenyl Chalcone Derivatives and Flavanoids of Fingerroot, Boesenbergia rotunda (L.) Towards Dengue-2 Virus NS3 Protease, Tan Siew Kiat, Richard Pippen, Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, and Noorsaadah Abd Rahman, Bioorganic and Medicinal Chemistry Letters, 2006, 16 (12). 3337-3340.
  77. Lee Yean Kee, Rozana Othman, Habibah Abdul Wahab, Rohana Yusof and Noorsaadah Abd. Rahman. 2006 A revisit into the DEN2 NS2B/NS3 Virus Protease Homology Model: Structural Verification and Comparison with Crystal Structure of HCV NS3/4A and DEN2 NS3. Malaysia Journal of Science, 25 (1): 15-22
  78. Noorsaadah Abd. Rahman, Hadinur, Sylvia Muliawan, Nurshamimi Nor Rashid, Mudiana Muhamad and Rohana Yusof. 2006. Studies on Q. Lusitanica extracts on Dengue Virus Type-2 Replication. Dengue Bulletin , 30 , 260 -269
  79. Sylvia Y. Muliawan,Lam sai Kit, Shamala Devi, onn Hashim and Rohana Yusof (2006). Inhibitory potential of Quercus lusitanica extract on dengue virus type 2 replication. Southeast Asian Journal of Tropical medicine and public health. 37 (suppl 3)
  80. Tan Siew Kiat, Richard Pippen, Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, and Noorsaadah Abd Rahman. 2006. Inhibitory Activity of Cyclohexenyl Chalcone Derivatives and Flavanoids of Fingerroot, Boesenbergia rotunda (L.)towards Dengue-2 Virus NS3 Protease. Bioorganic & Medicinal Chemistry Letters, 16(12), 3337- 3340.
  81. Noorsaadah Abd. Rahman, T.K. Teoh and Rohana Yusof (2005). A search for Dengue 2 Virus Inhibitor From Tripeptides and Hexapeptides . Malaysian Journal of Science 24
  82. SK Tan, R.Pippen, R Yusof, H Ibrahim, N Rahman and N Khalid (2005) Simple one-medium formulation regeneration of fingerroot (Boesenbergia rotunda [L.]Mansf. Kulturpfl.) via somatic embroyogenesis In Vitro Cellular & Development Biology Plant, 2005, 41(6), 757-761
  83. Saied R. Doustjalali, Rohana Yusof, Gopala K. Govindasamy, Anita Z.Bustam, Bhanumathy Pillay and Onn H.Hashim (2005) Patients with nasopharyngeal carcinoma demonstrate enhanced serum and tissue ceruloplasmin expression J.Med. Invest.53 (1-2):20-8
  84. Sylvia Y. Muliawan, Lam Sai Kit, Khalifah Sidik, Noorsaadah abdul Rahman, Onn Haji Hashim, Rohana Yusof. 2005. Inhibitory potential of Quercus lusitanica galls extract on the protein expressions of dengue virus type 2 . J.of Science and Technology of the Tropics vol.1,no. 2
  85. Mun-Yik Fong, Roziyah Yusup, Rohana Yusof and Sai-Kit Lam , "Neurovirulence of four encephalitogenic dengue 3 virus strains isolated in Malaysia (1992-1994) is not attributed to their envelope protein", 2004, Trans. R. Soc. Trop. Med. Hyg., Vol. 98, pg. 379-381
  86. R. Yusof, H.Y. Yong, A.M. Mustafa and G.E. Blair , "Modulation of major Histocompatibility Complex (MHC) class I heavy chain gene expression by Naringenin in cells that express human papillomavirus (HPV) E6 and E7 genes", 2004, Vol. 12, pg. 33-38
  87. Saeid R. Doustjalali, Rohana Yusof, Cheng-Har Yip, Lai- Meng Looi, Bhanumathy Pillay and Onn H. Hashim. 2004. Abberant expression of acute-phase reactant proteins in sera and breast lesions of patients with malignant and benign breast tumors. Electrophoresis Vol. 25, pg. 2392-2401
  88. Hadinur, Noorsaadah Abdul Rahman, Khalifah Sidik and Rohana Yusof (2003). Screening and isolation of active fraction of extracts from tropical plant for inhibitory activity towards NS2B/NS3 dengue protease. In the effect of conformation on protein function. universiti Putra Malaysia, Press, 2003, p48-53
  89. Muliawan S.Y,Lam S.K., Hashim O.H and yusof,R (2003). Protein expression of dengue virus type 2 in two dimensional electrophoresis.J.Clin.Virol.28 (suppl 1),S-30
  90. Rozana Othman, Rohana Yusof and Noorsaadah Abdul Rahman (2003). Molecular Modelling study of the dengue virus NS2B cofactor and NS3 protease. In the effect of the conformation on protein function. Universiti Putra malaysia, Press,2003,p32-33
  91. Sarni Mat Junit, Shatrah Othman, Rohana Yusof, Michael A. Billett and Fatimah Harun , "Ala519Thr mutation in exon 11of LDL receptor gene in members of a Malaysian family with hypercholestrolaemia", 2003, Vol. 11, no. 2, pg. 77-82
  92. Teh Chee Kheng,Rohana Yusof and Noorsaadah Abd. Rahman (2003) Construction of Combinatorial Library of Cyclopeptides And Screening For Biological Activities Malaysian Journal of Science 22: 29-34.
  93. Teoh,K.T., Rahman ,N.A and Yusof, R. (2003). Synthesis and identification of small molecules as potential anti0dengue NS2B/3 protease inhibitor.In the effect of conformation on protein function. Universiti putra malaysia Press, 2003, p42-47
  94. L.K. Teh, R. Ismail, R. Yusof, A. Hussein, M.N. Isa and A.R.A. Rahman.2001. Heterogeneity of CYP2D6 gene among Malays in Malaysia Journal of Clinical Pharmacy and Therapeutics 26, 1-7
  95. S.R.D,Jalali,R.Yusof,L.M.Looi,C.H.Yip,I.Othman and O.Hashim (2001). The human breast cancer serum proteome:analysis by two-dimensional gel electrophoresis and silver staining. Mal.J.Bio Mol.Biol;6;p60
  96. S.R.D.Jalali,R.Yusof,L.M,Looi,C.H,Yip,I.,Othman and O.hashim (2001).The human breast cancer serum proteome:analysis by two-dimensional gel electrophoresis and detection by enzyme conjugated Chempedak seed Lectin-C.Mal.J.Bio Mol.Biol;6;p63
  97. R. Yusof, S. Clum, M. Wetzel, H.M. Krishna Murthy and R. Padmanabhan.2000. Purified NS2B/NS3 serine protease of dengue virus type 2 exhibits cofactor NS2B dependence for cleavage of substrates with dibasic amino acids in vitro.Jounal of Biological Chemistry 275, pg. 9963-9969
  98. Stephanie, Y, Yusof, R.., C.L Cheah, S.C and Leslie, C.L.O (1999). Partial nucleotide sequence of an oleosin cDNA from Elaies guineensis. J.Oil Palm Research (Special issue) p18-23
Article in Proceeding
  1. Abd Rahman N., Ibrahim F., Ainehvand M., Yusof R., Madou M. (2018) An Effect of Magnetic Beads to Boesenbergia rotunda Antioxidant Activity Using Photoprotective Microfluidic CD. In: Ibrahim F., Usman J., Ahmad M., Hamzah N., Teh S. (eds) 2nd International Conference for Innovation in Biomedical Engineering and Life Sciences. ICIBEL 2017. IFMBE Proceedings, vol 67. Springer, Singapore
  2. Nurshamimi Nor Rashid, Rohana Yusof, Roger J.Watson (2011). Disruption of p130/DREAM complexes by HPV 16E6/E7. 21st asia Pacific Cancer Conference, KLCC
  3. Nurshamimi Nor Rashid, Rohana Yusof, Roger J.Watson (2011). HPV E7 resulted in loss of specific DREAM complexes. 36th Annual Conference of the MSBMB, Petaling Jaya.
  4. Nurshamimi Nor Rashid, Rohana Yusof, Roger J.Watson (2011). HPV disrupts repressive DREAM complexes in cervical cancer cell proliferation. 4th Regional Conference of molecular Medicine (RCMM), Penang.
  5. Ahmad Rashidi, H.S., Yusof, R. and Abdul Rahman, N. Construction of Dengue Virus-2 Domain III Envelope Protein 12th IUBMB, 21st FAOBMB and ComBio2010 Conference, 26th sept 1st oct 2010, Melbourne , Australia
  6. Effects of HPV Oncoproteins on HLA-A2 Promoter in Cervical Carcinoma Cell Line Mohd Habib S.H., Abdullah A., Othman S., Karsani S.A., and Yusof R. 12th IUBMB, 21st FAOBMB and ComBio2010 Conference, 26th sept 1st oct 2010, Melbourne ,Australia
  7. Othman, S, Abdul Rahman, N and Yusof, R Modulation of MHC Class 1 Gene Expression by Dengue Virus 12th IUBMB, 21st FAOBMB and ComBio2010 Conference, 26th sept 1st oct 2010, Melbourne , Australia
  8. Yaacob, N., Yusof, R., Abdul Majid, N., Karsani, S.A. Isolation and Identification of Candidate Host Protein Receptor of Dengue Virus Human Proteome (HUPO) World Congress 2010, Sydney, Australia, September 19- September 23, 2010
  9. Azahemy Abdullah, Shafina Hanim Habib, Lim Boon Keong and Rohana Yusof. Effect of HPV E6 and E7 Proteins on the Activity of MHC Class I Promoter. 33rd Annual Conference of the MSBMB, Kuala Lumpur. 27th-28th August 2008
  10. Mudiana Muhammad, Tan Siew Kiat, Noorzulaini Khalid, Noorsaadah Abdul Rahman, Rohana Yusof. Inhibitory action of purified compound from Boesenbergia rotunda plant extracts toward dengue virus type-2 (DEN2) replication in vitro. Joint conference of the 33rd FEBS congress/11th IUBMB conference, Greece 28 Jun -3 July 2008 (ISI)
  11. Shatrah Othman, Noorsaadah Abd. Rahman and Rohana Yusof. Dengue virus up-regulates the Promoter Activity of the MHC Class I Gene. 33rd Annual Conference of the MSBMB, Kuala Lumpur. 27th-28th August 2008
  12. Shatrah Othman, Noorsaadah Abdul Rahman and Rohana Yusof. The effect of Dengue virus on the regulatory elements in HLA-A2 promoter. The 2nd International conference on dengue and dengue haemmorhagic fever in Phuket, Thailand. 15-17th October 2008.
  13. Azahemy Abdullah, Nurshamimi Nor Rashid, Shatrah Othman, Lim Boon Kiong, Rohana Yusof. Modulation of MHC Class I Promoter Expression By Human Papillomavirus E6/E7 Protein. 24th International Papillomavirus Conference and Clinical Workshop, Beijing, China. 3rd -9th November 2007
  14. Noorsaadah Abdul Rahman, Rohana Yusof, Rozana Othman. Structure-based Design of a Dengue Virus Serine Protease Inhibitor. Proceeding to The Conference & Expo of International Drug Discovery Science and Technology, Shanghai, China, 28 May 5 June 2007
  15. Rohana Yusof, Mudiana Mohamed,Nurshamimi Nor Rashid, Noorsaadah Abdul Rahman. Antiviral and Proteomic Studies on DenV-2 Infection , Rohana Yusof. The Conference & Expo of International Drug Discovery Science and Technology, Shanghai, China, 28 May 5 June 2007. Invited Oral Presentation chair of session
  16. Rohana Yusof. Therapeutic based approach against dengue virus infection. The 32nd annual conference of the Malaysian Society for Biochemistry and Molecular Biology. 5 6 September 2007,Eastin Hotel ,Petaling Jaya. Invited Plenary Speaker.
  17. Azahemy Abdullah, Lim Boon Kiong, and Rohana Yusof. Molecular cloning of human papillomavirus type 16 E2 gene. 9th A-IMBM Conference and 16th MSMBB Meeting, 4th 5th September 2006, Kuala Lumpur.
  18. Lee Yean Kee, Tan Siew Kiat, Habibah Abdul Wahab, Rohana Yusof and Noorsaadah Abd. Rahman . "Nonsubstrate Based Inhibitors of Dengue Virus Serine Protease: A Molecular Docking Approach to Study Binding Interactions between Protease and Inhibitors. World Congress on Medical Physics and Biomedical Engineering, Seoul, Korea, August-September 2006 (proceedings published).
  19. Mudiana Muhamad, Tan Siew Kiat, Norzulaani Khalid, Noorsaadah Abdul Rahman, Rohana Yusof Investigation of Antiviral Activity by Boesenbergia rotunda extracts on Dengue Virus Infection in Cultured Cell Lines The 31st Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, 17th August 2006, Bangi, Selangor
  20. Noorsaadah Abdul Rahman, Lee Yean Kee, Rozana Othman, Tan Siew Kiet, Nurzulani Khalid, habibah Wahab and Rohana Yusof. Structure- based design of a therapeutic inhibitor for NS2B/NS3 protease of Dengue virus type 2. 38thNational convention of the S A Chemical Institute 3-8th December 2006, University of Kwazulu-Natal, Durban, South Africa
  21. Nurshamimi Nor Rashid, Noorsaadah Abdul Rahman and Rohana Yusof. Effect of glychyrirhizin on dengue virus serotype-2 protein profiling. The 31st Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, 17th August 2006, Bangi, Selangor
  22. Rohana Yusof , Lim Boon Kiong, Noorsaadah Abdul Rahman and Rohana Yusof. Therapeutic target for cervical cancer treatment. 38thNational convention of the S A Chemical Institute 3-8th December 2006, University of Kwazulu-Natal, Durban, South Africa
  23. Rozana Othman, David Rice, Svetlana Sedelnikova, Rohana Yusof and Noorsaadah Abdul Rahman. Attempts towards crystallization of dengue type-2 protease complex. Trends in Biotechnology 3, 5th-6th September, 2006, IOI Marriott, Putrajaya.
  24. Rozana Othman, Mudiana Mohamed, Tan Siew Kiat, Nurzulani Khalid, Noorsaadah Abdul Rahman and Rohana Yusof. Inhibitory activity of compounds isolated from Boesenbergia rotunda (L.) towards dengue type 2 protease. Biomalaysia, Kuala Lumpur 6 8th December 2006.
  25. Shatrah Othman, Noorsaadah Abdul Rahman and Rohana Yusof The use of UA-technique in the molecular cloning of NS2B.NS3 soluble protease gene of dengue -2 virus. Trends in Biotechnology 3, 5th-6th Septtember, 2006, IOI Marriott, Putrajaya.
  26. Lee Yean Kee, Teoh Kim Tat,Loh Hwee Ying, Tan Siew Kiat, Habibah Wahab, Rohana Yusof, Norzulaani Khalid and Noorsaadah Abd Rahman (2005) A search for a dengue virus serine protease inhibitor: Docking and molecular interactions approaches.2nd Asian regional dengue research network meeting p150
  27. Nurshamimi Nor Rashid, Noorsaadah Abdul Rahman and Rohana Yusof (2005) Effect of compound X on C6/36 cell lines in the study of antiviral effect of dengue virus type-2 replication. 30th annual conference of the Malaysian Society for Biochemistry and molecular Biology
  28. R.D Vaithilingam, T.B.Taiyeb Ali,R.Yusof and H.Hassan (2005) Identification of two periodontopathogens in adults with advanced chronic periodontitis. International Association for Dental Research and South East Asia association for dental education meeting pg81
  29. S.Y. Muliawan, S.K.Lam, O.H.Hashim, S.Devi and R.Yusof (2005) Inhibitory effect of Dillenia suffruticosa extract on the dengue virus type 2 protease and NS1 protein expression. 2nd Asian regional dengue research network meeting p157
  30. Azahemy Abdullah, Lim Boon Kiong, Onn Haji Hashim and Rohana Yusof (2004) HPV detection and biomarkers screening as the potential solution to cervical cancer persistency. Proc.Molecular Biology and Biotechnology scientific meeting p44
  31. Lee Yean Kee, Noorsaadah Abdul Rahman and Rohana Yusof (2004) Search for potential small molecule dengue virus protease inhibitor Proc.Structural Biology Colloquim 2004, p27
  32. Rozana Othman, Rohana Yusof and Noorsaadah Abdul Rahman (2004) Structure prediction of dengue virus type 2 protease Proc.Structural Biology Colloquim 2004, p33
  33. S.Y.Muliawan, S.K.Lam, OH.Hashim, S.Devi, NA. Abdul Rahman, R.Yusof (2004) Inhibitory effect of Q.lusitanica extract on the dengue virus type-2 protease and NS1 protein expression. Pediatric dengue vaccine initiative p22
  34. Sylvia Muliawan, Lam Sai Kit, Khalifah Sidik, Shamala Devi, Onn hashim, Noorsaadah Abdul Rahman and Rohana Yusof. (2004) Inhibitory potential of Quercus Lusitanica Galls Extract on the protein expressions of dengue virus type 2. Discovery on Target: Functional Genomic and Target validation conference p19
  35. Teoh Kim Tat, Noorsaadah Abd Rahman and Rohana Yusof (2004) A search for dengue 2 virus inhibitor from tripeptides and hexapeptides. 8th International Conference on chemistry and its role in development (ICCRD 8), Sharm-El Sheikh, Egypt
  36. Teoh Kim Tat, Noorsaadah Abdul Rahman and Rohana Yusof (2004) Development of tripeptide and hexapeptide libraries and cyclopeptides as potential dengue protease inhibitors. International conference of Bioinformatics p97
  37. Teoh Kim Tat, Noorsaadah Abdul Rahman and Rohana Yusof (2004) Development of tripeptide, hexapeptide libraries and cyclopeptides as potential dengue protease inhibitor , Proc.Structural Biology Colloquim 2004, p24
  38. Zuriati Zainol, Mohd Rais Mustafa, Noorsaadah Abdul Rahman, Norsulaani Khalid and Rohana Yusof (2004) Development of technique for extraction of carpaine from carica papaya (exotica) and the identification of polyketide synthase gene as the modulator. Proc.Molecular Biology and Biotechnology scientific meeting p117
  39. Abdullah A., Abdul Aziz N., Lim B.K., Othman I. and Yusof R. (2003) Screening for human Papillomavirus from clinical samples using a combination of consensus primer mediated and type-specific PCR. Proc. 28th annual conference of the Malaysian society for biochemistry and molecular biology p66
  40. Doustjalali S.R, Abdul Rahman P.S., Shuib A.S., Yusof R., Othman I., Yip C.H., Looi L.M. and Hashim O.H. (2003) Lectin generated serum proteome of patients with breast disorders Proc. 28th annual conference of the Malaysian society for biochemistry and molecular biology p79
  41. Hadinur, Noorsaadah Abdul Rahman and Rohana Yusof (2003) Inhibitory potential of Manjakani (Quercus lusatinica) seeds on dengue virus type-2 protease activity Proc. 14th National Biotechnology Seminar P61
  42. Muliawan S.Y., Lam S.K., Hashim O.H. and Yusof R. (2003) A proteomic study on the inhibitory effect of Quercus lusitanica against dengue virus type 2 Proc. 28th annual conference of the Malaysian society for biochemistry and molecular biology p95
  43. Teoh Kim Tat, Noorsaadah Abdul Rahman and Rohana Yusof (2003) Synthesis and identification of libraries of tripeptides as potential anti-dengue NS2B/3 protease inhibitor Proc. 14th National Biotechnology Seminar P48
  44. Zainol Z, Mustafa M.R., Rahman N.A., Khalid N. and Yusof R. (2003) Using biotechnological approach to enhance the production of carpaine, a potential lead structure for anti-hypertension in carica papaya Proc. 28th annual conference of the Malaysian society for biochemistry and molecular biology p73
  45. Hadinur, Sidik K., Junit S.M., Rahman N.A. and Yusof. R. (2002).Inhibitory potential of water-based extracts from tropical plants on dengue virus type 2 protease activity. Proc. 27th annual conference of the Malaysian society for Biochemistry and Molecular Biology. p55
  46. Chong W.K., Teoh K.T., Rahman N.A andYusof R. (2002). Screening of small molecules for potential anti-dengue protease inhibitor. Proc. 27th annual conference of the Malaysian society for Biochemistry and Molecular Biology. p53
  47. Doustjalali S.R, Yusof R, Looi LM, Yip C.H., Govindasamy G.K., Bustam A.Z., Othman I. and Hashim O. (2002). Serum proteome maps of treated patients with breast cancer and nasopharangeal carcinoma . Proc. 27th annual conference of the Malaysian society for Biochemistry and Molecular Biology. p70
  48. Hadinur, Khalifah Sidik, Sarni Mat Junit, Noorsaadah Abdul Rahman and Rohana Yusof(2002). Screening of Extracts from Tropical Plant for Inhibitory Activity towards Dengue Protease. Symposium on Protease. Moscow, Russia. p80.
  49. Hadinur, S.M.,Junit, N.,Abdul Rahman, F.B.H., Ahmad, K. Sirat and R. Yusof (2002) Screening of extracts from Natural Product and Organic compounds for inhibitory activity towards dengue protease Proc. 12th annual meeting for Malaysian Society for Molecular Biology and Biotechnology. p91
  50. Hadinur, Sidik K, Junit S.M, Rahman N.A and Yusof R. (2002) Purification and identification of components from Mimosa pudica extracts as inhibitors of dengue protease. . Proc. 27th annual conference of the Malaysian society for Biochemistry and Molecular Biology. p54
  51. EMZ Izam, H Samsinah, Y Rohana, C Wiart.2001.Development of superoxide dismutase enzyme assay and screening of plant with potential anti- inflammatory activity.Asia Pacific Journal of Pharmacology. Proceedings of the 16th Scientific meeting of the Malaysian Society of Pharmacology and Physiology 15(Suppl 2):S70
  52. S.R.D jalali, R.Yusof,L.M Looi,C.H,Yip,I.Othman and o.Hashim (2001). The human breast cancer two- dimensional serum protein expression maps generated by silver staining and and lectin detection methods. proc 13th National Biotechnology Seminar,p387
  53. S.S.Mohamed, S.Hussein, R.Yusof and C.Wiart (2001). Method development of reverse transcriptase inhibitory activity. Asia Pacific Journal of Pharmacology, Vol 15 Supp 2,p43
  54. Teoh,K.T, Chong,W.K,Sidik,K., Junit,S.M and Yusof,R (2001). Screening of compounds with inhibitory activity towards dengue protease. Mal.J. Bio.Mol. Biol;6;p64
  55. Teoh.K.T,K.Sidik,S.M,Junit and R.Yusof (2001).Screening of plant extracts for anti-protease activity of dengue virus. Proc 11th Malaysian Society of Molecular Biology and biotechnology,p39
  56. S.Othman,F.harun,R.Yusof,M.S.Billett and S.M Junit (2000). Peripheral blood mononuclear cells as a source of RNA for sequencing LDL receptor gene associated with familial hypercholestrolemia. Proc.10th scientific meeting of the Malaysian Society for Molecular Biology and Biotechnology,p51
  57. Y.D.Muthiah,P.S.A Rahman and R.Yusof (2000). Cloning and expression of dengue virus envelope protein. Proc.10th scientific meeting of the Malaysian Society for Molecular biology and Biotechnology.p54
  58. Y.D.Muthiah,P.S.A,Rahman,Z.Ishak,S.K lam and R.Yusof (2000). The expression of dengue envelope protein for the detection of dengue antibody.Proc.12th National Biochemistry Seminar

RESEARCH PROJECT

National
  1. 2009 - 2012, MOSTI (IRPA)
    Hits-to-leads: Designing dengue Virus Inhibitors ( Consultant)
  2. 2007 - 2011, Geran Penyelidikan Universiti Malaya (UMRG)
    Proteomic and Genomic Analysis Of Colorectal Polyps And Cancer ( Consultant)
  3. 2007 - 2009, ScienceFund
    Development of chemotherapeutic agents for dengue diseases ( Consultant)
  4. 2006 - 2008, Mosti (IRPA)
    Development of chemotherapeutic agents for dengue diseases ( PROJECT LEADER)
  5. 2005 - 2007, SAGA (ASM)
    Design of chemotherapeutic agent for dengue virus protease ( PROJECT LEADER)
  6. 2005 - 2007, MOSTI (IRPA)
    Design of chemotherapeutic agent for dengue virus protease ( Principal Investigator(PI))
  7. 2004 - 2006, Yayasan Felda Berhad
    Enhancement of the Natural Production of Carpaine in Papaya (Carica papaya L.) var. Eksotika through Biotechnological Approach ( Principal Investigator(PI))
  8. 2002 - 2005, Mosti (IRPA)
    The application of proteomics technology in the identification and exploitation of novel bioactive proteins ( Consultant)
  9. 2002 - 2005, MOSTI (IRPA)
    The effect of conformation on protein function ( Consultant)
  10. 2002 - 2005, MOSTI (IRPA)
    The application of proteomics technology in the identification and exploitation of novel bioactive proteins ( Consultant)
  11. 2002, Mosti (IRPA)
    The effect of conformation on protein function ( Consultant)
  12. 1998 - 2001, Mosti (IRPA)
    Determination of NS5 transcriptional activation function and its involvement in transactivation of cellular gene in dengue infected cells ( PROJECT LEADER)
  13. 1998 - 2000, MOSTI (IRPA)
    Determination of NS5 transcriptional activation function and its involvement in transactivation of cellular gene in dengue infected cells ( Principal Investigator(PI))
  14. 1997 - 1999, Mosti (IRPA)
    Molecular studies of cytokine action on human papillomavirus infected cells in cervical cancer ( PROJECT LEADER)
  15. 1996 - 1999, Mosti (IRPA)
    Molecular studies of the interaction between MHC class I and dengue haemorrhagic fever ( PROJECT LEADER)
  16. 1997 - 1999, MOSTI (IRPA)
    Molecular studies of cytokine action on human papillomavirus infected cells in cervical cancer ( Principal Investigator(PI))
  17. 1996 - 1996, IRPA
    Molecular studies of the interaction between MHC Class I and dengue haemorrhagic fever ( Principal Investigator(PI))

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2011) molecular characterization of novel arthoreoviruses isolated in Malaysia, (Internal Examiner)
  2. (2010) Molecular mechanism of acute phase respond: identification of signal transduction pathways mediating the cytokine inhibitory effect on human peroxisome proliferation activated receptor alpha (PPARa) in liver cells, (Internal Examiner)
  3. (2010) External examiner for Bachelor degree of Medicine and surgery, and Bachelor degree of Dentistry and surgery, International Medical University (IMU)., (Assessor panel)
  4. (2009) Leadership in Higher education: Framing the future, (Editor)
  5. (2009) External examiner for year 1 MBBS course USIM, (Course assessor)
  6. (2009) ADEPT Higher Education Bulletin, (Editor)
  7. (2009) AKEPT monograph series, (Editor)
  8. (2009) AKEPT sharing of minds series, (Editor)
  9. (2008) Biochimia and Biophysic Acta, (Reviewer)
  10. (2007) External examiner for Dentistry and Surgery course UiTM , (Course assessor)
  11. (2006) Development of a plant virus epitope presentation vector expressing dengue 2 virus antigens, (Internal Examiner)
  12. (2006) Flavanoids from Boesenbergia rotunda (L.) Mansf: Chemistry, bioactivity and accumulation, (Internal Examiner)
  13. (2006) Molecular regulation of peroxisome proliferators activated receptot alpha (PPARa) gene expression by interleukin-6 (IL-6) in human hepatocarcinoma HepG2 cell line, (External Examiner)
  14. (2006) Kajian antiproliferasi dan mekanisme kematian sel oleh triterpina akar eurycoma longifolia, (External Examiner)
  15. (2006) Screening for microbial inhibitors of signal transduction particularly the AKT/GST-3B pathway, (External Examiner)
  16. (2006) effect of processing on the protein content and the texture profile of canned Achatina fulica, (External Examiner)
  17. (2005) Pengklonan, pengekspresan dan pencirian protease serin Burkholderia pseudomallei, (External Examiner)
  18. (2005) Construction of combinatorial library of cyclopeptides and screening for anti-infective activiest, (Internal Examiner)
  19. (2005) Plasma protein expression profiles and Pax 8 gene mutation(s) screening of patients with congenital hypothyroidism, (Internal Examiner)
  20. (2005) Antigeinicity of EBV latent membrane protein 1 (LMP 1) from nasopharyngeal carcinoma, (Internal Examiner)
  21. (2005) Biomedical imaging and intervention Journal, (Reviewer)
  22. (2004) Molecular cloning and characterization of 5'-end and promoter regiosn of lipoprotein lipase (LPL) gene from bovine, (External Examiner)
  23. (2003) The application of mannose binding Champedak lectin in the isolation and detection of human serum glycoproteins, (Internal Examiner)
  24. (2003) Isolation of actinomycetes from Sabah and the screening for inhibitors against eukaryotic transduction, (External Examiner)
  25. (2003) Molecular cloning and characterization of 5'-untranslated and promoter regions of peroxisome proliferators activated receptor alpha (PPARa) from human, (External Examiner)
  26. (2003) Conversion MSc-Ph.D , (Assessor)
  27. (2003) 28th Biochemistry and Molecular Biology Conference, (Scientific committee)
  28. (2003) Leadership courses and all activities involving students of Ibnu Sina Residential College , (Advisor)
  29. (2003) The Asia Pacific Journal of molecular Biology and Biotechnology, (Reviewer)
  30. (2003) Comparative Biochemical, pharmacological and ultra-structural studies on Malaysian jelly fish: Chrysaora Quingnecirrha, chrysaora hysoscella and rhopilema hispidium, (Internal Examiner)
  31. (2003) The application of galactose binding Champedak lectin in the isolation and detection of human serum glycoproteins, (Internal Examiner)
  32. (2002) National Science Fund and Skim Pembiayaan pengajian Pasca Siswazah bagi pegawai dalam perkhidmatan, (Interview panel)
  33. (2002) 27th Biochemistry and molecular biology conference, (Scientific committee)
  34. (2002) Department of Molecular Medicine, Faculty of Medicine , (Technical committee)
  35. (2002) Experimental Applied Research (EAR) IRPA RM8 University Putra malaysia (Science sector and engenering) , (Technical assessor panel)
  36. (2002) The characterization and application oggalactose binding lectin from the seeds of Champedak (artocarpus integer), (Internal Examiner)
  37. (2002) Journal of the University Malaya Medical Centre, (Reviewer)
  38. (2001) Society of Biochemistry and Molecular Biology Malaysia, (Committee member)
  39. (2001) Characterization of LDL-receptor gene mutation(s) in a malaysian familial hypercholesterolaemic patient, (Internal Examiner)
  40. (2001) Application for M.Med.Science and Ph.D, ('Ad-Hoc' committee assessor)
  41. (2000) Isolation and characterization of Tetrodotoxin (TTX) from Malaysian Pifferfish Gastrophysus Lunaris, Torquigener oblongus and Chelonodn Fluviatilis and its effect on the nervoues system, (Internal Examiner)
  42. (2000) Construction of Escheria coli arginine repressor fusion protein and anlysis of its funtion in XER site-specific recombination, (Internal Examiner)
  43. (2000) Fulbright Alumni Malaysia Society, (Committee member)
  44. (1999) The Malaysian Journal of Biochemistry and molecular Biology, (Reviewer)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2019) Rational Discovery of Novel NS3 Enzyme Inhibitors for Genotype 3 Hepatitis C Virus, LIM SEE KHAI
  2. (2018) INVESTIGATION ON THE EFFECT OF SELECTED COMPOUNDS ON THE ANTI-AGING PROPERTIES IN NORMAL HUMAN DERMAL FIBROBLAST CELLS, ZALIYATUN AKHMA BT MAT YASIN
  3. (2015) Rational Drug Discovery for HCV inhibitor, Lim See Khai
  4. (2015) Investigation of Selected Plant Extract with Anti-Aging Properties, Zaliyatun Akhma Mat Yasin
  5. (2014) Designing and developing antiviral peptide-fusion proteins against Flaviviruses propagation in vitro and in vivo, Ammar Yasir Abdulrahman
  6. (2014) DESIGN AND DEVELOPMENT OF NEW CELL-PENETRATING PEPTIDES (CPP) AS DRUG DELIVERY SYSTEM FOR CANCER CHEMOTHERAPY,, Jamunaa Ambikabothy
  7. (2011) Disruption of mammalian DREAM complexes by human papillomavirus E7 proteins, Nurshamimi Nor Rashid
  8. (2010) Study on enzyme inhibitors from selected plants on the replication of dengue virus, Shatrah othman
  9. (2010) Design and synthesis of a potential inhibitor for DEN2 NS2B/NS3 serine protease, Lee Yean Kee
  10. (2009) Molecular modeling study of dengue virus type-2 protease, Rozana Othman
  11. (2008) Mechanism of inhibition by Boesenbergia rotunda plant extracts on Dengue Virus type-2 (DENV2) replication, Mudiana Muhammad @ Mohd Saufi
  12. (2007) Dengue virus, Ravindran Thayan
  13. (2006) Proteomics and lectin-based profiling of proteins in sera of patients with endometrial and cervical carcinoma, Puteri Shafinaz Akmar Abdul Rahman
  14. (2005) Proteomics analysis on dengue virus type-2 replication, Dr.Sylvia Muliawan
  15. (2005) Natural Product with antidengue activity, Melika Miraskari
  16. (2003) Protein expression in patients with malignant and benign tumors of the breast and nasopharyngeal carcinoma, Saeid Reza Doust Jalali
Master
  1. (2019) Investigating Zika Virus Dependency On Glucose and Glutamine Metabolism in Neural Progenitor Cells, Muhammad Izzuddin Bin Mohd Ropidi
  2. (2018) MICROFLUIDIC LAB-ON-DISC APPROACH OF 2.2-DIPHENYL-1-PICRYLHYDRAZYL ANTIOXIDANT ASSAY, NURHASLINA BINTI ABD RAHMAN
  3. (2015) Recombinant Peptide Fusion Proteins as Inhibitors Against HCV Protease, Mohamad Nabil Fiqry Mohd Tamrin
  4. (2015) Inhibitory Effect of Peptide Fusion Protein Expressed in Pichia Pastoris Against Hepatitis C Virus, Norsakinah Yusoff
  5. (2015) A Study of an Electrical and Mechanical Properties of Tissues on Animal an Human After Consuming the Medicine Plant Extract for Anti-Aging Purposes, Nurhaslina Abd Rahman
  6. (2014) Finding of Potential Hepatitis C Virus Inhibitors through Screening of Traditional Chinese Medicine, Tee Kah Ching
  7. (2011) The effects of the synthetic antiviral compound (YK51) on the proteome of dengue virus serotype II infected HepG2 cells using 2DE-MS, Tan Wei Lian
  8. (2011) Protein profiling of an in vitro cell culture, Tan Eng Chong
  9. (2011) Competitive inhibitors of dengue-2 virus: Kinetic analysis of synthetic and natural compound of Boesenbergia rotunda using BIAcore, Rufaidah Othman
  10. (2011) Biological activities of Quercus infectoria aqueos extract toward dengue-2 NS2B/NS3 protease, Ammar Y. Abdul Rahman
  11. (2011) An in-vitro investigation into the binding of dengue 2 domain 3 envelope protein to host cells, Hani Shahira Ahmad Rashidi
  12. (2008) Docking and synthesis of cyclic peptides as possible inihibitors for dengue virus type 2 NS2B/NS3 serine protease, Loh Hwee Ying
  13. (2006) Anti-viral effect of local extract on dengue virus type-2 replication, Nurshamimi Nor Rashid
  14. (2004) Development of peptides as inhibitor of dengue virus serotype 2 (Den 2) protease, Teoh Kim Tat
  15. (2003) Genotyping and identification of high-risk human papillomavirus from cervical specimen using PCR approach, Norhaslinda bt Abdul Aziz
  16. (2002) Periodontal status and its association to actinobacillus actinomycetencomitans and prevotella intermedia in the three ethnic adult Malaysian Population with advanced chronic periodontitis, Dr Rathna Devi Vaithilingam
  17. (2002) Identification and purification of compounds from natural products as potential inhibitors towards dengue virus type-2 protease, Hadinur
  18. (2001) Sequencing of the prM(M)E and 3' noncoding region of malaysian dengue-3 viruses, Roziyah Yusup
  19. (2000) The effect of dengue virus (D2) infection on the MHC Class I gene expression, Sharifah Fariza Syed Omar
  20. (2000) The cloning and expression of Dengue serotype 2 (New Guinea C Strain) envelope protein, Yasotha Devi Muthiah
  21. (2000) Periodontal status and the microbile profile in the three ethnic adults Malaysian population with chronic advanced periodontis, Dr Luay Thanoon Younis
  22. (2000) Expression of amino-terminally truncated capsid (C), pre-membrane (PrM) and membrane (M), and carboxy-terminally truncated envelope (E) genes of a malaysian dengue-3 isolate in Escherichia coli expression system, Norshariza Nordin
  23. (1999) The effects of Naringenin on the Majot Histocompatibility Class I expression in the presence of Human papillomavirus E6 and E7 genes, Yong Hoi Yim
  24. (1998) Partial nucleotide sequence of an Oleosin cDNA from Elaeis guineensis, Stephanie Yong
  25. (1997) The effects of biologically active components in swiftlets (Aerodramus maximus) nest extract on the major histocompatibility class I gene expression in the presence of the human papillomavirus E6/E7 genes, Anna Di Napoli

PATENT/IPR

  • A NOVEL DENGUE PROTEASE ASSAY KIT, Patent, PI2012004925, 2012,
    Patent (National)
  • Universal Flavivirus Proteases Assay Kit
    Patent (National)
  • A KIT AND A METHOD FOR DETECTING AND QUANTIFYING STAPHYLOCOCCUS AUREUS ENDOTOXIN GENES
    Patent (National)
  • A medicament for treating Dengue
  • Novel compounds to treat Dengue
  • Medicament for Dengue fever