Curriculum Vitae

PROF. DR. MOHD RAIS BIN MUSTAFA

Honorary Professor
  • Department of Pharmacology
    Faculty of Medicine
  • +603-79674952

BIOGRAPHY


 

The main focus of   Mohammad Rais’s research are in the areas of Cardiovascular Pharmacology, Natural Products and Drug Discovery. He has published several articles in international peer-reviewed journals and at the same time highlighted the pharmacological actions of  several local medicinal plants  including daun ketum (Mitragyna speciosa), cekur (Kaempferia galanga) and kacip Fatimah (Labisia Pumila).  These studies have been made possible by a series of R & D grants which he  successfully obtained under the Malaysian Development Plans and High Impact Research Grants (UM). To promote a more systematic and collaborative research in natural products in University of Malaya, Rais  helped established the Centre for Natural Products Research and Drug Discovery (CENAR) in 2003.  He has also a keen interest in basic science research, particularly in the area of Vascular Pharmacology.  His current research include investigating the role of novel angiotensin peptides, nitrates and nitrites, flavonoids and several phytochemicals in the improvement of endothelial dysfunctions in hypertension and diabetes.  

 

Selected Publications

 

  • Autophagy through stress-activated signals: a cellular self-defence mechanism against MBIC in human breast cancer cell-lines. Mohadeseh Hasanpourghadi, Nazia Abdul Majid, Mohd Rais Mustafa. Biochemical Pharmacology. doi: 10.1016/j.bcp.2018.03.030 (ISI-Indexed)
  • Choy KW, Lau YS, Murugan D, Mustafa MR (2017) Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress- mediated oxidative stress. PLoS ONE 12(5): e0178365. https://doi.org/10.1371/journal. pone.0178365 (ISI-Indexed)
  • Ling WC, Liu J, Lau CW, Murugan DD, Mustafa MR, Huang Y. (2017).Treatment with salvianolic acid B restores endothelial function in angiotensin II-induced hypertensive mice. Biochem Pharmacol. 2017 Jul 15;136:76-85.
  • Wei Chih Ling, Mohd Rais Mustafa, Paul M Vanhoutte, Dharmani Devi Murugan. (2017). Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascul Pharmacol. 2017 May 26. pii: S1537-1891(16)30268-3
  • Choy KW, Mustafa MR, Lau YS, Liu J, Murugan D, Lau CW, Wang L, Zhao L, Huang Y. 2016.Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARδ signaling pathway. Biochem Pharmacol. 2016 Sep 15;116:51-62.

 

 

 

AREAS OF EXPERTISE


  • OTHER PHARMACOLOGY
    Angiotensin II, Des-Aspartate Angiotensin I, Angiotensin 1-7
  • OTHER PHARMACOLOGY
    Endothelial dysfunctions in diabetes, cancer, ageing and cardiovascular associated disorders
  • TRADITIONAL MEDICINE AND NATURAL PRODUCT
    Flavonoids (Quercetin), Traditional Chinese Medicine, Boldine, Paeonol, Labisia Pumila, Apocynum Venetum, Hibiscus Sabdariffa

ACADEMIC QUALIFICATION


  • PHD, (Lain-Lain)
    University of Wales, Institute of Sci. & Technical
  • BSC, (Lain-Lain)
    University of Wales Institute, Cardiff, UK

ADMINISTRATIVE DUTIES


  • Deputy Dean of Research
    01 Aug 2014 - 31 Jul 2016 (Dean's Office, Faculty of Medicine)
  • Head of CENAR (Centre For Natural Product And Drug Discovery)
    01 Jan 2015 - 31 Dec 2016 (University Malaya)
  • Head
    01 Jan 2015 - 31 Dec 2015 (Centre for Natural Product and Drug Discovery (Cenar), Faculty of Medicine)
  • Deputy Dean of Research
    01 Jul 2014 - 31 Jul 2014 (Dean's Office, Faculty of Medicine)
  • Deputy Dean of Research
    01 Feb 2014 - 30 Jun 2014 (Dean's Office, Faculty of Medicine)
  • Research Cluster Dean
    03 Jan 2012 - 31 Dec 2012 (Health & Translational Medicine, Deputy Vice-Chancellor (Research and Innovation))
  • Research Cluster Dean
    01 Jan 2011 - 31 Dec 2011 (Health & Translational Medicine, Deputy Vice-Chancellor (Research and Innovation))
  • Deputy Dean
    01 Nov 2009 - 30 Jun 2011 (Dean's Office, Faculty of Medicine)
  • Research Cluster Dean
    01 Jan 2010 - 31 Dec 2010 (Health & Translational Medicine, Deputy Vice-Chancellor (Research and Innovation))
  • Research Cluster Dean
    01 Jan 2009 - 31 Dec 2009 (Health & Translational Medicine, Deputy Vice-Chancellor (Research and Innovation))
  • Deputy Dean
    01 Sep 2009 - 31 Oct 2009 (Dean's Office, Faculty of Medicine)
  • Head of Department
    01 Sep 2008 - 31 Aug 2009 (Department of Pharmacology, Faculty of Medicine)
  • Head of Department
    01 Sep 2007 - 31 Aug 2008 (Department of Pharmacology, Faculty of Medicine)

MEMBERSHIPS


  • BRITISH PHARMACOLOGICAL SOCIETY, MEMBER
    2009 to 2018 (International)
  • JAWATANKUASA MAKMAL FAKULTI PERUBATAN, ORIDINARY MEMBER
     (University)

AWARD AND STEWARDSHIP


  • KHIDMAT SETIA 30 AWARD
    , 2013
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2009 (University)
  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2008 (University)
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2007 (University)
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2006 (University)
  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2005 (University)
  • Royal Society UK-Malaysian Fellowship for a postdoctorate research attachment at the University of Birmingham, U.K.
    Royal Society UK, 1998 (International)
  • JSPS Postdoctoral Research Attachment
    Japanese Society for the Promotion of Science (JSPS), 1992 (International)
  • IBRO-Pan Asian First Intensive Workshop on Basic Neuroscience fellowship
    International Brain Research Organisation, 1988 (International)

PUBLICATIONS


Article in Journal
WoS
  1. Choy, K. W., Zain, Z. M., Murugan, D. D., Giribabu, N., Zamakshshari, N. H., Lim, Y. M., & Mustafa, M. R. (2021). Effect of Hydrolyzed Bird's Nest on beta-Cell Function and Insulin Signaling in Type 2 Diabetic Mice. Frontiers in Pharmacology, 12, 11. doi: 10.3389/fphar.2021.632169
Others
  1. Therapeutic Implications of Nitrite in Hypertension WC Ling, MR Mustafa, DD Murugan Journal of Cardiovascular Pharmacology 75 (2), 123-134
  2. Vernodalin induces apoptosis through the activation of ROS/JNK pathway in human colon cancer cells N Mohebali, AK Pandurangan, MR Mustafa, SK Anandasadagopan, ... Journal of Biochemical and Molecular Toxicology, e22587
  3. Autophagy through stress-activated signals: a cellular self-defence mechanism against MBIC in human breast cancer cell-lines. Mohadeseh Hasanpourghadi, Nazia Abdul Majid, Mohd Rais Mustafa. Biochemical Pharmacology. doi: 10.1016/j.bcp.2018.03.030
  4. Choy KW, Murugan D, Mustafa MR. (2018). Natural products targeting ER stress pathway for the treatment of cardiovascular diseases. Pharmacol. Res, 132, 119-129
  5. Choy, K. W., Lau, Y. S., Murugan, D., Vanhoutte, P. M., & Mustafa, M. R. (2018). Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently. Journal of Pharmacology and Experimental Therapeutics, 364(3), 420-432.
  6. Hasanpourghadi M, Abdul Majid N, Rais Mustafa M (2018). The role of miRNAs 34a, 146a, 320a and 542 in the synergistic anticancer effects of methyl 2-(5-fluoro-2-hydroxyphenyl)-1H- benzo[d]imidazole-5-carboxylate (MBIC) with doxorubicin in breast cancer cells. PeerJ 6:e5577 https://doi.org/10.7717/peerj.5577
  7. Hasanpourghadi, M., Pandurangan, A. K., & Mustafa, M. R. (2018). Modulation of oncogenic transcription factors by bioactive natural products in breast cancer. Pharmacological Research, 128, 376-388.
  8. Lai SL, Mustafa MR, Wong PF. Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway. Phytomedicine. 2018 Mar 15;42:144-151. doi: 10.1016/j.phymed.2018.03.027
  9. Lau, Y. S., Mustafa, M. R., Choy, K. W., Chan, S. M. H., Potocnik, S., Herbert, T. P., et al. (2018). 3 ',4 '-dihydroxyflavonol ameliorates endoplasmic reticulum stress-induced apoptosis and endothelial dysfunction in mice. Scientific Reports, 8.1818
  10. Ling, W. C., Mustafa, M. R., Vanhoutte, P. M., & Murugan, D. D. (2018). Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascular Pharmacology, 102, 11-20.
  11. Tong KL, Mahmood Zuhdi AS, Wan Ahmad WA, Vanhoutte PM, de Magalhaes JP, Mustafa MR and Wong PF. Circulating MicroRNAs in Young Patients with Acute Coronary Syndrome. Int. J. Mol. Sci. 2018, 19, 1467; doi:10.3390/ijms19051467
  12. Choy KW, Lau YS, Murugan D, Mustafa MR (2017) Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress- mediated oxidative stress. PLoS ONE 12(5): e0178365. https://doi.org/10.1371/journal. pone.0178365
  13. Hasanpourghad, M et al., (2017). Phytometabolites Targeting the Warburg Effect in Cancer Cells: A Mechanistic ReviewCurrent Drug Targets Volume: 18 Issue: 9 Pages: 1086-1094
  14. Kunasegaran T, Mustafa MR, Achike FI, Murugan DD. (2017). Quercetin and pioglitazone synergistically reverse endothelial dysfunction in isolated aorta from fructose-streptozotocin (F-STZ)-induced diabetic rats.Eur J Pharmacol. 2017 Mar 15;799:160-170
  15. Ling WC, Liu J, Lau CW, Murugan DD, Mustafa MR, Huang Y. (2017).Treatment with salvianolic acid B restores endothelial function in angiotensin II-induced hypertensive mice. Biochem Pharmacol. 2017 Jul 15;136:76-85.
  16. Oncotarget. 2017 Apr 25; 8(17): 28840 28853. Published online 2017 Mar 16. doi: 10.18632/oncotarget.16263
  17. Wei Chih Ling, Mohd Rais Mustafa, Paul M Vanhoutte, Dharmani Devi Murugan. (2017). Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascul Pharmacol. 2017 May 26. pii: S1537-1891(16)30268-3
  18. Wong PF, Jamal J, Tong KL, Khor ES, Yeap CE, Jong HL, Lee ST, Mustafa MR, Abubakar S (2017). Deregulation of hsa-miR-20b expression in TNF-alpha-induced premature senescence of human pulmonary microvascular endothelial cells. Microvascular Research 2017; 114:26-33. https://doi.org/10.1016/j.mvr.2017.06.002
  19. Choy KW, Mustafa MR, Lau YS, Liu J, Murugan D, Lau CW, Wang L, Zhao L, Huang Y. 2016.Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPAR signaling pathway. Biochem Pharmacol. 2016 Sep 15;116:51-62.
  20. Hasanpourghadi M, Karthikeyan C, Pandurangan AK, Looi CY, Trivedi P, Kobayashi K, Tanaka K, Wong WF, Mustafa MR. 2016. Targeting of tubulin polymerization and induction of mitotic blockage by Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) in human cervical cancer HeLa cell. J Exp Clin Cancer Res. 2016 Mar 31;35:58.
  21. Kunasegaran T, Mustafa MR, Murugan DD, Achike FI. 2016. The bioflavonoid quercetin synergises with PPAR- agonist pioglitazone in reducing angiotensin-II contractile effect in fructose-streptozotocin induced diabetic rats. Biochimie. 2016 Jun;125:131-9.
  22. Leong KH, Looi CY, Loong X-M, Cheah FK, Supratman U, Litaudon M , Mustafa MR, Awang K (2016) Cycloart-24-ene-26-ol-3-one, a new cycloartane isolated from leaves of Aglaia exima triggers tumour necrosis factor-receptor 1-mediated caspase-dependent apoptosis in colon cancer cell line. PLoS One.
  23. Leong KH, Looi CY, Loong XM, Cheah FK, Supratman U, Litaudon M, Mustafa MR, Awang K. 2016. Cycloart-24-ene-26-ol-3-one, a New Cycloartane Isolated from Leaves of Aglaia exima Triggers Tumour Necrosis Factor-Receptor 1-Mediated Caspase-Dependent Apoptosis in Colon Cancer Cell Line. PLoS One. 2016 Apr 12;11(4):e0152652. doi:
  24. Ling WC, Murugan DD, Lau YS, Vanhoutte PM, Mustafa MR. (2016). Sodium nitrite exerts an antihypertensive effect and improves endothelial function through activation of eNOS in the SHR. Sci Rep. 2016 Sep 12;6:33048
  25. Pandurangan AK, Mohebali N, Hasanpourghadi M, Looi CY, Mustafa MR, Mohd Esa N. 2016. Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF- B and IL-6/STAT3 as potential targets. Biofactors. 2016 May;42(3):247-58.
  26. Shanmugam MK, Lee JH, Chai EZ, Kanchi MM, Kar S, Arfuso F, Dharmarajan A, Kumar AP, Ramar PS, Looi CY, Mustafa MR, Tergaonkar V, Bishayee A, Ahn KS, Sethi G. 2016.Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds. Semin Cancer Biol. 2016 Mar 30. pii: S1044-579X(16)30009-8.
  27. Ananda Sadagopan SK, Mohebali N, Looi CY, Hasanpourghadi M, Pandurangan AK, Arya A, Karimian H, Mustafa MR. 2015. Forkhead Box Transcription Factor (FOXO3a) mediates the cytotoxic effect of vernodalin in vitro and inhibits the breast tumor growth in vivo. J Exp Clin Cancer Res. 2015 Dec 8;34:147
  28. Arya A, Al-Obaidi MM, Karim RB, Taha H, Khan AK, Shahid N, Sayem AS, Looi CY, Mustafa MR, Mohd MA, Ali HM. 2015. Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves -cell function in streptozotocin-nicotinamide induced diabetic rats. J Ethnopharmacol. 2015 Dec 4;175:229-40
  29. Lau Y.S., Ling, W.C, Murugan D, Kwan C.Y. and M.R. Mustafa, 2015. Endothelium-Dependent Relaxation Effect of Apocynum venetum Leaf Extract via Src/PI3K/Akt Signalling Pathway. Nutrients 2015, 7, 5239-5253; doi:10.3390/nu7075220
  30. Saadatdoust Z, Pandurangan AK, Ananda Sadagopan SK, Mohd Esa N, Ismail A, Mustafa MR. 2015. Dietary cocoa inhibits colitis associated cancer: a crucial involvement of the IL-6/STAT3 pathway. J Nutr Biochem. 2015 Dec;26(12):1547-58
  31. Venoos Iman, Hamed Karimian, Syam Mohan, Yahya Hasan Hobani, Mohamed Ibrahim Noordin, Mohd Rais Mustafa and Suzita Mohd Noor. 2015. In vitro and in vivo anti- angiogenic activity of girinimbine isolated from Murraya koenigii. Drug Design, Development and Therapy.
  32. Liew SY, Looi CY, Paydar M, Cheah FK, Leong KH, Wong WF, et al. Subditine, a New Monoterpenoid Indole Alkaloid from Bark of Nauclea subdita (Korth.) Steud. Induces Apoptosis in Human Prostate Cancer Cells. PloS one. 2014;9(2):e87286.
  33. Rusmili MRA, Yee TT, Mustafa MR, Othman I, Hodgson WC. In-vitro Neurotoxicity of Two Malaysian Krait Species (Bungarus candidus and Bungarus fasciatus) Venoms: Neutralization by Monovalent and Polyvalent Antivenoms from Thailand. Toxins. 2014;6(3):1036-48.
  34. Rusmili MRA, Yee TT, Mustafa MR, Othman I, Hodgson WC. Isolation and characterization of α-elapitoxin-Bf1b, a postsynaptic neurotoxin from Malaysian< i> Bungarus fasciatus venom. Biochemical pharmacology. 2014 Mar 15;88(2):229 36.
  35. Shawish HB, Paydar M, Looi CY, Wong YL, Movahed E, Halim SNA, et al. Nickel (II) complexes of polyhydroxybenzaldehyde N4-thiosemicarbazones: synthesis, structural characterization and antimicrobial activities. Transition Metal Chemistry. 2014;39(1):81-94.
  36. Arya A, Looi CY, Wong WF, Noordin MI, Nyamathulla S, Mustafa MR, et al. In vitro Antioxidant, PTP-1B Inhibitory Effects and in vivo Hypoglycemic Potential of Selected Medicinal Plants. Int J Pharmacol. 2013 Jan;9(1):50-7.
  37. Cheah S-C, Lai S-L, Lee S-T, Hadi AHA, Mustafa MR. Panduratin A, a Possible Inhibitor in Metastasized A549 Cells through Inhibition of NF-Kappa B Translocation and Chemoinvasion. Molecules. 2013;18(8):8764-78.
  38. Gummadi VR, Rajagopalan S, Looi CY, Paydar M, Renukappa GA, Ainan BR, Krishnamurthy NR, Panigrahi SK, Mahasweta K, Raghuramachandran S, Rajappa M, Ramanathan A, Lakshminarasimhan A, Ramachandra M, Wong PF, Mustafa MR, Nanduri S, Hosahalli S. Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4911-8. doi: 10.1016/j.bmcl.2013.06.071.
  39. Jong HL, Mustafa MR, Vanhoutte PM, AbuBakar S, Wong PF. 2013. MicroRNA 299-3p modulates replicative senescence in endothelial cells.Physiol Genomics. 2013 Apr 1;45(7):256-67. doi:10.1152/physiolgenomics.00071.2012
  40. Lau YS, Tian XY, Mustafa MR, Murugan D, Liu J, Zhang Y, et al. Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II‐mediated BMP4‐oxidative stress cascade. British journal of pharmacology. 2013;170(6):1190-8.
  41. Lee ST, Wong PF, He H, Hooper JD, Mustafa MR. 2013. Alpha-tomatine synergises with paclitaxel to enhance apoptosis of androgen-independent human prostate cancer PC-3 cells in vitro and in vivo. Phytomedicine. 2013 Aug 3. doi:pii: S0944-7113(13)00246-8. 10.1016/j.phymed.2013.07.002.
  42. Lee ST, Wong PF, He H, Hooper JD, Mustafa MR. 2013. Alpha-tomatine attenuation of in vivo growth of subcutaneous and orthotopic xenograft tumors of human prostate carcinoma PC-3 cells is accompanied by inactivation of nuclear factor-kappa B signaling. PLoS One. 2013;8(2):e57708.
  43. Leong X-F, Rais Mustafa M, Jaarin K. Nigella sativa and Its Protective Role in Oxidative Stress and Hypertension. Evidence-Based Complementary and Alternative Medicine. 2013 Jan;2013.
  44. Looi CY, Arya A, Cheah FK, Muharram B, Leong KH, Mohamad K, et al. Induction of Apoptosis in Human Breast Cancer Cells via Caspase Pathway by Vernodalin Isolated from Centratherum anthelminticum (L.) Seeds. PloS one. 2013;8(2):e56643.
  45. Looi CY, Moharram B, Paydar M, Wong YL, Leong KH, Mohamad K, et al. Induction of apoptosis in melanoma A375 cells by a chloroform fraction of Centratherum anthelminticum (L.) seeds involves NF-kappaB, p53 and Bcl-2-controlled mitochondrial signaling pathways. BMC complementary and alternative medicine. 2013 July 10;13(1):166.
  46. Syam Mohan, Siddig Ibrahim Abdelwahab, Shiau-Chuen Cheah, Mohd Aspollah Sukari, Suvitha Syam, Noorasyikin Shamsuddin, et al. Apoptosis Effect of Girinimbine Isolated from Murraya koenigii on Lung Cancer Cells In Vitro. Evidence-Based Complementary and Alternative Medicine. 2013 Feb 12;2013.
  47. Tiong SH, Looi CY, Hazni H, Arya A, Paydar M, Wong WF, et al. Antidiabetic and Antioxidant Properties of Alkaloids from Catharanthus roseus (L.) G. Don. Molecules. 2013 Aug 15;18(8):9770-84.
  48. Yeh Siang Lau, Xiao Yu Tian, Mohd Rais Mustafa, Dharmani Murugan, Jian Liu, Yang Zhang, Chi Wai Lau, Yu Huang i, Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II-mediated BMP4-oxidative stress cascade.08/2013; 5.07 Impact Factor
  49. Abdelwahab, S.I., W.S. Koko, M.M.E. Taha, S. Mohan, M. Achoui, M.A. Abdulla, M.R. Mustafa, S. Ahmad, M.I. Noordin, and C.L. Yong.In vitro and in vivo anti-inflammatory activities of columbin through the inhibition of cycloxygenase-2 and nitric oxide but not the suppression of NF- B translocation. European journal of pharmacology. 2011;678(2012):61-70.
  50. Aditya Arya, Chung Yeng Looi, Shiau Chuen Cheah, Mohd Rais Mustafa and Mustafa Ali Mohd. 2012. Anti-diabetic effects of Centratherum anthelminticum seeds methanolic fraction on pancreatic cells, β-TC6 and its alleviating role in type 2 diabetic rats. Journal of Ethnopharmacology. 2012 Oct 31;144(1):22-32.(Impact factor 3.014)
  51. Aditya Arya, Shiau Chuen Cheah, Chung Yeng Looi, Hairin Taha, Mohd. Rais Mustafa and Mustafa Ali Mohd. 2012.The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats. Food and Chemical Toxicology (Impact factor 2.99). 2012 Nov;50(11):4209-20
  52. Arbab IA, Looi CY, Abdul AB, Cheah FK, Wong WF, Sukari MA, et al. Dentatin Induces Apoptosis in Prostate Cancer Cells via Bcl-2, Bcl-xL, Survivin Downregulation, Caspase-9,-3/7 Activation, and NF-κB Inhibition. Evidence-Based Complementary and Alternative Medicine. 2012;2012.
  53. Arya, A., Achoui, M., Cheah, S. C., Abdelwahab, S. I., Narrima, P., Mohan, S., Mustafa, M. R., Mohd, M. A. Chloroform Fraction of Centratherum anthelminticum (L.) Seed Inhibits Tumor Necrosis Factor Alpha and Exhibits Pleotropic Bioactivities: Inhibitory Role in Human Tumor Cells. Evidence-Based Complementary and Alternative Medicine. 2012;2012.
  54. Johari, J., Kianmehr, A., Mustafa, M.R., AbuBakar, S., & Zandi, K. 2012. Antiviral activity of baicalein and quercetin against Japanese encephalitis virus. International Journal of Molecular Science. 13(12): 16785-95
  55. Johari, J., Kianmehr, A., Mustafa, M.R., AbuBakar, S., & Zandi, K. 2012. Antiviral activity of baicalein and quercetin against Japanese encephalitis virus. International Journal of Molecular Sciences. 13(12):16785-95
  56. Lai SL, Cheah SC, Wong PF, Noor SM and Mustafa MR. 2012. In vitro and In vivo Anti-angiogenic Actvities of Panduratin A. PLoS One. 2012;7(5):e38103.
  57. Lau YS, Tian XY, Huang Y, Murugan D, Achike FI, Mustafa MR. Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism. Biochemical pharmacology. 2012 Feb 1;85(3):367-75.
  58. Siddig Ibrahim Abdelwahab, Abdelwahab Hassan Mohamed, Osama Yousif Mohamed, Majhbob Oall, Manal Mohamed Elhassan Taha, Syam Mohan, Mohamed Ibrahim Noordin, Mohd Rias Mustafa and Khalid M. Alkharfy. Erectogenic effects of Clerodendron capitatum: involvement of phosphodiesterase type-5 inhibition. Evidence-Based Complementary and Alternative Medicine. Volume 2012 (2012), Article ID 137386, 6 pages
  59. Sook Yee Liew, Mat Ropi Mukhtar, A. Hamid A. Hadi, Khalijah Awang, Mohd Rais Mustafa, Kazumasa Zaima, Hiroshi Morita and Marc Litaudon, Naucline, a New Indole Alkaloid from the Bark of Nauclea officinalis, Molecules 2012, 17, 4028-4036
  60. Tan PJ, Appleton DR, Mustafa MR, Lee HB. Rapid Identification of Cyclic Tetrapyrrolic Photosensitisers for Photodynamic Therapy Using On-line Hyphenated LC-PDA- MS Coupled with Photo-cytotoxicity Assay. Phytochemical Analysis. 2011;23(1):52-9.
  61. Yeh-Siang L, Ajay M, Achike FI, Murugan D, Mustafa MR. The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats. Experimental Biology and Medicine. 2012;237(1):93-8
  62. Zandi K, Teoh BT, Sam SS, Wong PF, Mustafa MR and AbuBakar S. 2012. Novel antiviral activity of baicalein against dengue virus. BMC Complementary and Alternative Medicine, 12:214 doi:10.1186/1472-6882-12- 214, Published: 9 November 2012
  63. Zandi, K., Lani, R., Wong, P.F., Teoh, B.T., Sam, S.S., Johari, J., Mustafa, M.R., AbuBakar, S. 2012. Flavone enhances dengue virus type-2 (NGC strain) infectivity and replication in vero cells. Molecules. 17(3):2437-45
  64. Zandi, K., Lani, R., Wong, P.F.,Teoh, B.T., Sam, S.S., Johari, J., Mustafa, M.R., AbuBakar, S.Flavone Enhances Dengue Virus Type-2 (NGC Strain) Infectivity and Replication in Vero Cells. Molecules. 2012;17(3):2437-45.
  65. Aloysuis, U. I., Achike, F. I., Mustafa, M. R. 2011. Mechanisms underlining gender differences in Phenylephrine contraction of normoglycaemic and short-term Streptozotocin-induced diabetic WKY rat aorta. Vascular Pharmacology.
  66. Chong YM, Yin WF, Ho CY, Mustafa MR, Hadi AHA, Awang K, et al. 2011. Malabaricone C from Myristica Cinnamomea Exhibits Anti-Quorum Sensing Activity. Journal of Natural Products.74(10):2261-4.
  67. Jaarin K, Mustafa MR, Leong XF. The effects of heated vegetable oils on blood pressure in rats. Clinics. 2011;66(12):2125-32.
  68. Khan, H., I. Ali, A.U. Khan, M. Ahmed, Z. Shah, A. Saeed, R. Naz, M.R. Mustafa, and A. Abbasi. Purification and Biochemical Characterization of Alkaline Serine Protease from Caesalpinia Bonducella. Natural Product Communication. 2011; 5(6):931-4.
  69. Lau Yeh-Siang , Gopal Subramaniam , A. Hamid A. Hadi , Dharmani Murugan and Mohd Rais Mustafa, Reactive Oxygen Species-Induced Impairment of Endothelium-Dependent Relaxations in Rat Aortic Rings: Protection by Methanolic Extracts of Phoebe grandis, Molecules 2011, 16(4), 2990-3000
  70. Lee ST, Wong PF, Cheah SC, Mustafa MR. Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells. PLoS One. 2011;6(4):e18915
  71. Leong XF, Salimon J, Mustafa MR, Jaarin K. Effect of Repeatedly Heated Palm Olein on Blood Pressure Regulating Enzymes Activity and Lipid Peroxidation in Rats. 2011.
  72. Liew SY, Mukhtar MR, Awang K, Mustafa MR, Ng SW. 1-(1- Hydroxyethyl)-7, 8-dihydroindolo [2, 3-a] pyridine [3, 4- g] quinolizin-5 (13H)-one (angustoline) monohydrate from Nauclea subdita (Rubiaceae). Acta Crystallographica Section E: Structure Reports Online. 2011;67(7):o1727-o8
  73. Shiau-Chuen Cheah, David R. Appleton, Sui-Ting Lee , May-Lynn Lam ,A. Hamid A. Hadi and Mohd. Rais Mustafa,Panduratin A Inhibits the Growth of A549 Cells through Induction of Apoptosis and Inhibition of NF- KappaB Translocation,Molecules 2011, 16, 2583-2598
  74. Zandi K, Teoh BT, Sam SS, Wong PF, Mustafa MR, AbuBakar S. In vitro antiviral activity of Fisetin, Rutin and Naringenin against Dengue virus Type-2. Journal of Medicinal Plants Research (2011) Vol. 5 (23), pp. 5534-5539.
  75. 2010: Leong Xin-Fang; Mustafa Mohd Rais; Das Srijit; Jaarin Kamsiah Association of elevated blood pressure and impaired vasorelaxation in experimental Sprague-Dawley rats fed with heated vegetable oil. Lipids in health and disease 2010;9():66.
  76. Kassim Mustafa; Achoui Mouna; Mustafa Mohd Rais; Mohd Mustafa Ali; Yusoff Kamaruddin Mohd Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti- inflammatory activity. Nutrition research (New York, N.Y.) 2010;30(9):650-9
  77. MUHARIS, SP; TOP, AGM; MURUGAN, D; MUSTAFA, MR. 2010. Palm oil tocotrienol fractions restore endothelium dependent relaxation in aortic rings of streptozotocin- induced diabetic and spontaneously hypertensive rats. Nutrition Research, 30: 209-216
  78. Mouna Achoui; David Appleton; Mahmood Ameen Abdulla; Khalijah Awang; Mustafa Ali Mohd; Mohd Rais Mustafa. (2010). In Vitro and In Vivo Anti-inflammatory Activity of 17-O-Acetylacuminolide through the Inhibition of Cytokines, NF- Translocation and IKK ctivity. Plos ONE, PONE-D-10-02204
  79. 2009: Subramaniam G; Achike Francis I; Mustafa M R Characterizing the mechanisms of insulin vasodilatation of normal and streptozotocin-induced diabetic rat aorta. Journal of cardiovascular pharmacology 2009;53(4):333-40.
  80. Chung LY, Lo MW, Mustafa MR, Goh SH, and Imiyabir Z (2009). 5-Hydroxytryptamine(2A) receptor binding activity of compounds from Litsea sessilis. Phytotherapy research : 23(3) 330-4,
  81. LY Chung, WK Soo, KY Chan, MR Mustafa, SH Goh, Z Imiyabir "Lipoxygenase inhibiting activity of some Malaysian plants", 2009, Pharm Biol,
  82. LY Chung, WK Soo, MR Mustafa, SH Goh, Z Imiyabir, "5- Hydroxytryptamine1A receptor binding activity of bisbenzyltetrahydroisoquinoline alkaloids from Popowia odoardoi", 2009, Pharm Biol,
  83. Leong XF, Najib MN, Das S, Mustafa MR, Jaarin K. 2009. Intake of repeatedly heated palm oil causes elevation in blood pressure with impaired vasorelaxation in rats. Tohoku J Exp Med.,Sep;219(1):71-8.
  84. Subramaniam G, Achike FI, Mustafa MR. Effect of acidosis on the mechanism(s) of insulin-induced vasorelaxation in normal Wistar- Kyoto (WKY) rat aorta. Regul Pept. 2009 Apr 10
  85. Amudha K, Choy AM, Mustafa MR, and Lang CC (2008). Short-term effect of atorvastatin on endothelial function in healthy offspring of parents with type 2 diabetes mellitus. Cardiovascular therapeutics 26(4):253-61
  86. Chung LY, Yap KF, Goh SH, Mustafa MR, and Imiyabir Z (2008). Muscarinic receptor binding activity of polyoxygenated flavones from Melicope subunifoliolata. Phytochemistry: 69(7):1548-54
  87. Dharmani M, Mustafa MR, Achike FI, and Sim MK (2008). Involvement of AT(1) angiotensin receptors in the vasomodulatory effect of des-aspartate-angiotensin I in the rat renal vasculature. Peptides 29(10):1773-80
  88. E. M. Tamil, T.S. Tey, M.R. Mustafa, M.Y.I. Idris and M. Nasir (2008). Automated Clinical Research Mice Movement Detection System. The International Journal of Technology, Knowledge and Society: 4 (6); 63-76.
  89. Einstein JW, Mustafa MR, Nishigaki I, Rajkapoor B, and Mohd MA (2008). Protective effect of different parts of Cassia fistula on human umbilical vein endothelial cells against glycated protein-induced toxicity in vitro. Methods and findings in experimental and clinical pharmacology 30(8):599-605
  90. H HUSSEIN, M.R. MUSTAFA, K. F. QUEK, N.S. HASSANUDIN and S. SHAHID (2008). Cross-cultural adaptation and validation of the Malay health assessment questionnaire for use in rheumatoid arthritis. International Journal of Rheumatic Diseases (Formerly APLAR Journal of Rheumatology): 11(3):237 - 240.
  91. M.R.Mukhtar, A.H.A. Hadi, D. Rondeau, P. Richomme, M. Litaudon, M.R. Mustafa, K. Awang (2008). New proaporphines from the bark of Pheobe Scortechini. Natural Products Research, 22 (11): 921-926.
  92. Chin LC, Achike FI, Mustafa M.R. (2007). Hydrogen peroxide modulates angiotensin II-induced contraction of mesenteric arteries from streptozotocin diabetic rats. Vascular Pharmacology, 46, 223-228.
  93. Dharmani M, Mustafa M.R, Achike FI, Sim MK (2007). Effects of Angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and Streptozotocin (STZ)-induced diabetic rats. European Journal of Pharmacology, 561: 144-150
  94. K. Awang, M.R.Mukhtar, M.R. Mustafa, M. Litaudon, K. Shaari, K. Mohamed and A.H.A. Hadi (2007). New Alkaloids from Pheobe Scortechini. Natural Products Research, 21 (8) : 704-709.
  95. M. Ajay, F.I. Achike, M.A. Mustafa, M.R. Mustafa (2007). Quercetin, a flavonoid antioxidant, modulates endothelium-derived nitric oxide bioavailability in diabetic rat aortas. Nitric Oxide 16, 442-447
  96. M. Ajay, F.I. Achike, M.A. Mustafa, M.R. Mustafa (2007). Baicalein impairs vascular tone in normal rat aortas: role of superoxide anions. Eur J Pharmacol., 565(1-3):144-50.
  97. M. Ajay, F.I. Achike, M.R. Mustafa (2007). Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant Flavonoid. Pharmacological Research, 55: 385-391
  98. M. Ajay, H.J. Chai, A.M. Mustafa, A.H. Gilani and M.R. Mustafa (2007). Mechanisms of the anti-hypertensive effect of Hibiscus sabdariffa L. calyces. Journal of Ethnopharmacology 109(3): 388-393.
  99. Ajay, M. Mustafa, M. R.
  100. M. Ajay, F.I Achike, Mustafa Ali Mohd and M.R. Mustafa. (2006) Effects of quercetin on altered vascular reactivity in aortas isolated from streptozotocin-induced diabetic rats. Diabetic Research and Clinical Practice, 73 (1), 1-7
  101. M. Ajay, F.I. Achike, M.A. Mohd, M.R. Mustafa (2006). Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortas: comparative study with ascorbic acid. Clinical and Experimental Pharmacology and Physiology, 33,345-350.
  102. O. Rozana, H. Ibrahim, A.M. Mohd, M.R. Mustafa and K. Awang (2006). Bioassay-guided isolation of the vasorelaxant active compound from Kaemferia galangal Linn. Phytomedicne, 13, 61-66.
  103. 129M. Dharmani, M.R. Mustafa, F.I. Achike, M.K. Sim, " Effect of des-aspartate-angiotensin I on the actions of angiotensin II in the isolated renal and mesenteric vasculature of hypertensive and STZ- induced diabetic rats.", 2005, Regul. Pept., Vol. 129, pg. 213-219,
  104. LY Chung, KF Yap, MR Mustafa, SH Goh, Z Imiyabir, "Muscarinic receptor activity of some Malaysian plant species", Pharmaceutical Biology, Vol. 43, no. 8, 2005, pg. 672-682.
  105. M. Ajay and M.R.Mustafa (2005). , "Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. ", 2005, J. Cardiovasc. Pharmacol., Vol. 46, pg. 36-40,
  106. Mustafa MR, Mahmood AA, Sidik K, Noor SM. Evaluation of wound healing potential of Ageratum conyzoides leaf extract in combination with honey in rats as animal model. International Journal of Molecular Medicine and Advance Sciences. 2005;1(4):406-10.
  107. Mustafa MR, Dharmani M, Kunheen NK, Sim MK. Effects of des-aspartate-angiotensin I on the actions of angiotensin III in the renal and mesenteric vasculature of normo-and hypertensive rats. Regulatory peptides. 2004;120(1-3):15-22.
  108. Ajay M, Gilani AH, Mustafa MR. Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta. Life sciences. 2003;74(5):603-12.
  109. Lang CC, Jamal SK, Mohamed Z, Mustafa MR, Mustafa AM, Lee TC. Evidence of an interaction between nifedipine and nafcillin in humans. British journal of clinical pharmacology. 2003;55(6):588-90.
  110. Othman R, Ibrahim H, Mohd MA, Awang K, Gilani AH, Mustafa MR. Vasorelaxant effects of ethyl cinnamate isolated from Kaempferia galanga on smooth muscles of the rat aorta. Planta medica. 2002;68(7):655-7.
  111. Mustafa MR, Johns EJ. The role of haem oxygenase in renal vascular reactivity in normotensive and hypertensive rats. Journal of hypertension. 2001;19(6):1105-11.
  112. Mustafa MR, Achike FI. Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation. Acta pharmacologica Sinica. 2000; 21(12):1165-8.
  113. Othman I., Fathilah AR., Mohd Saad J, Mohd Yusof M, Mustaffa MR and Nor Azila. Studies on the Venomous Coelenterate: Rhopilema hispidum. J Natural Toxins. 3 (5):361-375 (1996).
  114. Mustafa MR, Mohamad R, Din L, Wahid S. Smooth muscle relaxant activities of compounds isolated from malaysian medicinal plants on rat aorta and guinea pig ileum. Phytotherapy Research. 1995;9(8):555-8.
  115. Mustafa MR, White E, Hongo K, Othman I, Orchard CH. THE MECHANISM UNDERLYING THE CARDIOTOXIC EFFECT OF THE TOXIN FROM THE JELLYFISH CHIRONEX FLECKERI. Toxicology and Applied Pharmacology. 1995 Aug;133(2):196-206.
  116. Orchard CH, Mustafa MR, White E. OSCILLATIONS AND WAVES OF INTRACELLULAR [CA2+] IN CARDIAC-MUSCLE-CELLS. Chaos Solitons & Fractals. 1995 Mar-Apr;5(3-4):447-58.
Chapter in Books
  1. Mohadeseh Hasanpourghadi & Mustafa, M.R. (2018). TGF- /Smad Signalling Pathway in Cancer in Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs, pp. 151-186.
  2. Farooqi AA. & Ismail, M. (Eds). (2017). Molecular Oncology: Underlying Mechanisms and Translational Advancements. Springer.
  3. M. Ajay and M.R. Mustafa (2008). Vascular Protective Effects of Flavonoids in Animal Models of Hypertension and Diabetes. In Polyphenols and Health: New and Recent advances. Editor: Neville Vasallo. Nova Science Publishers, USA.

RESEARCH INTEREST


  • Natural Products and Drug Discovery
  • Novel Angiotensin peptides
  • Endothelial dysfunctions
  • Flavonoids (Quercetin, baicalein, )
  • Oxidative stress (Superoxides, NADPH, antioxidants)

RESEARCH PROJECT


National
  1. 2015 - 2017, NKEA Pertanian Research Scheme
    Protective effects of standardised Labisia pumila extracts against vascular dysfunction in diabetes ( Principal Investigator(PI))
  2. 2011 - 2015, High Impact Research (HIR)
    Molecular Mechanisms of Drugs Action ( Principal Investigator(PI))
  3. 2012 - 2014, High Impact Research (HIR)
    Mechanisms of the cardiovascular therapeutic potentials of boldine and nitrite in animal models of diabetes mellitus and hypertension H- 20001-00-E000055 ( Principal Investigator(PI))
  4. 2011 - 2014, High Impact Research (HIR)
    Circulating microRNAs as Novel Biomarkers for Early Detection of Atherosclerosis ( Consultant)
  5. 2011 - 2012, Geran Penyelidikan Universiti Malaya (UMRG)
    Molecular Staging of Senescence in Endothelial Cells ( Consultant)
  6. 2011 - 2012, Geran Penyelidikan Universiti Malaya (UMRG)
    Endothelial protective activity of aporphine alkaloids in animals models of diabetes mellitus and hypertension ( Consultant)
  7. 2009 - 2012, Geran Penyelidikan Universiti Malaya (UMRG)
    Tittle: TARGETING NUCLEAR FACTOR (NF) KAPPA B PATHWAY BY PHYTOCHEMICALS DERIVED FROM MALAYSIAN PLANTS FOR TREATMENT OF CANCER ( Principal Investigator(PI))
  8. 2006 - 2009, ScienceFund
    Role of free radicals in the development of endothelial dysfunction in diabetes mellitus ( Principal Investigator(PI))
  9. 2007 - 2009, Geran Penyelidikan Universiti Malaya (UMRG)
    Effects of chronic treatment of angiotensin peptides in development of type II Diabetes mellitus in GK rats ( Principal Investigator(PI))
  10. 2006 - 2008, ScienceFund
    Molecular Characteristics of the Anti-inflammatory activity of Malaysian Seaweeds ( Consultant)
  11. 2005 - 2007, SAGA Fund, Academy of Science Malaysia
    Syntheses of Analogs of Ethyl Cinnamate Vasorelaxant Compounds Based on In Silico and NMR Orientation in the Active Site of Cytochrome P- 450. ( Consultant)
  12. 2004 - 2006, Yayasan Felda Berhad
    Enhancement of the Natural Production of Carpaine in Papaya (Carica papaya L.) var. Eksotika through Biotechnological Approach ( Principal Investigator(PI))

CONSULTANCY PROJECT


  • Chronic Effects of Brands's Essence of Chicken Extracts On Vascular Endothelial Function in Hypertensive Animals., Cerebos Pacific Limited
    01 Apr 2005 - 01 Apr 2007 (International)
  • Oral Toxicity Test of Olescair in Rats, Autoimmune Sdn. Bhd.
    01 Apr 2005 - 01 Apr 2007 (International)
  • Hypoglycemic Effects of Bitter Gout in Normal and Diabetic Rats, Jun Herng Sdn. Bhd.
    01 Apr 2004 - 01 Apr 2006 (International)

PAPER PRESENTED


PLENARY SPEAKER
  1. ELEPHANT TRUNK, BIRDS NEST, CAT WHISKERS AND FATIMA S DAGGER: CAN NATURAL PRODUCTS FROM MALAYSIA TREAT DIABETES MELLITUS?, 5TH INTERNATIONAL MEDITERRANEAN SYMPOSIUM ON MEDICINAL AND AROMATIC PLANTS/5TH INTERNATIONAL SYMPOSIUM ON PHARMACEUTICAL AND BIOMEDICAL SCIENCES APRIL, 24-28, 2019 / CAPPADOCIA - TURKEY, Association of Medicinal and Aromatic Plants of Mediterranean (International) (24 Apr 2019 - 28 Apr 2019)
  2. MINING OF PHYTOCHEMICALS FOR CARDIOVASCULAR PROTECTION, 5TH INTERNATIONAL CONFERENCE, TECHNOLOGY DEVELOPMENT ON AGRICULTURE, ENERGY & ENVIRONMENTAL ENGINEERING FOR GREEN WORLD , Vivekenandha Educational Institution, INDIA (International) (18 Feb 2016 - 19 Feb 2016)
  3. Modulation of Oxidative stress and Endothelial protection by plant-derived products, International Conference on Natural Products 2014, Malaysian Natural Products Society (International) (18 Mar 2014 - 19 Mar 2014)
INVITED SPEAKER
  1. CHRONIC TREATMENT WITH PAEONOL PROTECTS AGAINST TUNICAMYCIN-INDUCED ENDOTHELIAL DYSFUNCTION THROUGH ATTENUATING OXIDATIVE STRESS AND ENDOPLASMIC RETICULUM STRESS, SCIENTIFIC FRONTIERS IN NATURAL PRODUCT BASED DRUGS 2017, National University of Singapore (International) (06 Jul 2017 - 07 Jul 2017)
  2. ENDOTHELIAL PROTECTIONS AND CVS HEALTH: MODULATIONS OF OXIDATIVE STRESS BY PLANT DERIVED PRODUCTS, SYMPOSIUM OF TRADITIONAL MEDICINES IN COUNTRIES ALONG MARITIME SILK ROAD , Zhejiang University (International) (05 Aug 2016 - 06 Aug 2016)
  3. PAENOL PROTECTS AGAINST TUNICAMYCIN-INDUCED OXIDATIVE STRESS AND ENDOTHELIAL DYSFUNCTION VIA AMPK/PPAR PATHWAYS, 13TH ASIA PACIFIC FEDERATION OF PHARMACOLOGIST MEETING, ASIA PACIFIC FEDERATION OF PHARMACOLOGISTS (International) (01 Feb 2016 - 03 Feb 2016)
  4. Endothelial protective effects and mechanisms of the NO releasing effects of the anti-hypertensive herb, Apocynum venetum, IUPHAR World Conference on the Pharmacology of Natural and Traditional Medicine,, IUPHAR (International) (22 Jul 2015 - 24 Jul 2015)
  5. Endothelial dysfunctions and CVS Health: Role of Natural Products, Joint Malaysia-UK symposium on natural Product Chemistry and Drug Discovery, International Medical University and Royal Society of Chemistry, UK (International) (13 Dec 2014 - 14 Dec 2014)
  6. ENDOTHELIAL PROTECTION AND MODULATION OF OXIDATIVE STRESS BY PLANTDERIVED PRODUCTS, 2nd International Conference on Natural Health, University of Mostagenam (International) (26 Oct 2014 - 28 Oct 2014)
  7. Boldine treatment improves endothelial dysfunction in streptozotocin-induced diabetes, 6th International Symposium on Vascular Biology 2012, China Medical University, Taiwan (International) (24 Mar 2012 - 25 Mar 2012)
  8. Pharmacological characterization of the mechanisms of the antioxidant effects of boldine in hypertensive rats, 4th International Symposium on Vascular Biology 2010, China medical University, Taichung, Taiwan (International) (27 Mar 2010 - 28 Mar 2010)
ORAL PRESENTER
  1. VERNODALIN INDUCE APOPTOSIS IN BREAST CANCER CELLS THROUGH ACTIVATION OF FORKHEAD BOX TRANSCRIPTION FACTOR, FOXO3A, 2ND MEDITERRANEAN SYMPOSIUM ON MEDICINAL AND AROMATIC PLANTS, NATURAL PRODUCTS SOCIETY OF TURKEY (AMAPMED) (International) (22 Apr 2015 - 25 Apr 2015)
  2. Free radical scavenging and NO releasing effects of the antihypertensive herb, Apocynum venetum, 3rd International congress of Traditional Chinese Modern Medicine and Traditional Uyghur Medicine, 15-20 Oct 2014, Xinjiang University (International) (15 Oct 2014 - 20 Oct 2014)
  3. Developing a TNF sensitization assay for screening of potential NF-kB inhibitors using the xCELLigence technology. , xCELLigence Symposium and User Meeting 2010 27-29 Oct 2010, , Roche Applied Scinces (International) (27 Oct 2010 - 29 Oct 2010)

ACADEMIC/PROF. SERVICES


Evaluation
  1. (2015) External Examiner for BDS Yr 2 program at MAHSA University, (External Examiner)
  2. (2014) PONE-D-14-20760 Enhanced protective effect of the combination of Uncaria and Semen Raphani on vascular endothelium in spontaneously hypertensive rats , (Reviewer)
  3. (2011) Review of of PLOS ONE article: PONE-D-11-06669 A Blueberry Enriched Diet Attenuates Nephropathy in a Rat Model of Hypertension via Reduction in Oxidative Stress, (Reviewer)
  4. (2011) Ref.: Ms. No. JEP-D-11-02174 Vasorelaxant effect of an infusion of Baccharis trimera (Less.) DC. on precontracted rat aortic rings. Journal of Ethnopharmacology , (Reviewer)
  5. (2011) Experimental Biology and Medicine Manuscript No. 1110-RM-357-, (Reviewer)
Contribution to external organisation
  1. (2015) AHLI PANEL TASK FORCE BAGI INSTRUMEN PUSAT KECEMERLANGAN PENGAJIAN TINGGI (HICoE), Kementerian Pelajaran Malaysia, National
  2. (2014) Consultative Meeting for Organisation of Islamic Countries, Committee of Scientific and Technical Cooperation (COMSTECH), International
  3. (2014) Technical Committee for Research and Development in Herbal Medicine, NATIONAL COMMITTEE FOR RESEARCH AND DEVELOPMENT IN HERBAL MEDICINE (NRDHM)
  4. (2013) Panel evaluator (Technical) for monitoring and evaluation of proposals for grants for RESEARCH ACCULTURATION COLLABORATIVE EFFORTS (RACE), Ministry of Education/

SUPERVISION


Postgraduate Student
PhD/ Doctoral
  1. (2014) Pharmacogenomics of Malaysian Asthmatic patients, Vijaya Lechimi Raj
  2. (2008) Vascular protective effects of flavonoids in diabetic animals, Umelo Aloysius Iguegbe
  3. (2008) Endothelial protective efefcts of aporphine alkaloids, Lau Yea Siang
  4. (2008) Cellulat toxicity evaluations of herbal medicines, Noorasyikin Shamsuddin
  5. (2008) Antiinflammatory activities of natural products, Mouna Achoui
  6. (2006) Pharmacological evaluation of the antidiabetic effects of Cassia fistula, John Wilkins Einstein
  7. (2000) Vascular dysfunction and atheroslerotic burden in common cardiovascular diseases, Amudha Kadirvelu
  8. (1998) Comparative Biochemical, Pharmacology and Ultrastructural Studies on Malaysian Jellyfishes, Rabindra Shair Baharuddin
Master
  1. (2009) Role of Reactive Oxygen Species in diabetic vasculopathy in microvessels, Chin Leh Choong (University of Malaya (UM))
  2. (2008) Pharmacokinetic and pharmacodynamic studies of novel BH4 analogues, Mohd Yusmaidie Aziz
  3. (2008) Molecular and Biochemical analysis of Interluekin 18 in Malaysian Asthmatics, Devika a/p Chinayah
  4. (2007) Measurement of vascular reactivity of rats fed with repeatedly heated oils, Leong Xin Fang (M0100121)
  5. (2006) Asssessment of plant extracts for insulin-like properties using rat adipocyte primary culture, Lim Siang ling
  6. (2004) Isolation and characterisation of compounds with muscarinic receptor activity from Melicope subunifoliolata and Ficus septica, Yap Kim Fah
  7. (2004) AntiLipoxygenase and 5HT1A-receptor binding activities of Malaysian Plants, Soo Wei kwan
  8. (2002) Cardiovascular effects of Hibiscus Sabdariffa, Chai Hann Juang
  9. (1999) Direct and modulatory effects of angiotensin peptides on vascular contractility in hypertensive rats, Nabisah K Kunheen
  10. (1998) Bioassay guided isolation of vasoactive constituents from Hibiscus Sabdariffa, Nauman Aziz

TEACHING


Master
  1. (2011) MBDS - Master Dental Pharmacology
  2. (2010) MBDS - Master Dental Pharmacology
Bachelor
  1. (2016) Medical Pharmacology (Ummp)
  2. (2015) Dental Pharmacology (Bds)
  3. (2015) UMMP - Medical Pharmacology
  4. (2014) BDS - Dental Pharmacology
  5. (2014) UMMP - Medical Pharmacology
  6. (2013) BDS - Dental Pharmacology
  7. (2013) BDS - Dental Pharmacology
  8. (2013) MWEF2103 - Central Nervous System & Therapy
  9. (2012) BDS - Dental Pharmacology
  10. (2012) MBBS - Medical Pharmacology
  11. (2012) MDEB3401 - Advanced Medical Pharmacology
  12. (2011) BDS - Dental Pharmacology
  13. (2011) MWEF1108 - Principles of Drug Action & Peripheral Nervous System
  14. (2011) MWEF2103 - Central Nervous System & Therapy

SOCIAL RESPONSIBILITY ACTIVITIES


  • Scientific Committee for UM Research Carnival 2015, (08 Oct 2015 - 10 Oct 2015)
  • International Silk Road Academy of Medical Sciences Meeting Xinjiang Medical University, China, (15 Oct 2014 - 17 Oct 2014)