Curriculum Vitae
AREAS OF EXPERTISE
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BACTERIOLOGY
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MOLECULAR PHARMACOLOGYTranscriptomics and metabolomics
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PHARMACOKINETICSAntimicrobial PK/PD
ACADEMIC QUALIFICATION
- Post-Graduate Certificate in Teaching & Learning, (Teaching & Learning)Taylor's University Malaysia
- PhD, (Philosophy)Monash University, Australia
- BPharm (Hons), (Pharmacy)Monash University, Australia
MEMBERSHIPS
- SECRETARY OF MALAYSIAN PHARMACISTS SOCIETY HOSPITAL PHARMACY/ CLINICAL PHARMACY CHAPTER, SECRETARY2024 to present (National)
- MALAYSIAN SOCIETY OF INFECTIOUS DISEASES AND CHEMOTHERAPY (MSIDC), MEMBER2020 to 2021 (National)
- HOSPITAL CHAPTER, MALAYSIAN PHARMACEUTICAL SOCIETY (MPS), COMMITTEE MEMBER2018 to 2021 (National)
- PHARMACY BOARD OF MALAYSIA, REGISTERED MEMBER2010 to 2020 (National)
- EUROPEAN SOCIETY OF CLINICAL MICROBIOLOGY AND INFECTIOUS DISEASES (ESCMID), MEMBER2018 to 2019 (International)
- MALAYSIAN PHARMACEUTICAL SOCIETY (MPS), MEMBER2018 to 2019 (National)
- PHARMACY BOARD OF AUSTRALIA, REGISTERED MEMBER2010 to 2017 (International)
- AUSTRALIAN SOCIETY FOR MICROBIOLOGY (ASM), MEMBER2015 to 2016 (International)
- AMERICAN SOCIETY FOR MICROBIOLOGY (ASM), MEMBER2015 to 2016 (International)
- PHARMACY BOARD OF VICTORIA, REGISTERED MEMBER2009 to 2010 (International)
AWARD AND STEWARDSHIP
- Institut Merieux - MSIDC Young Investigator AwardInstitut Merieux and Malaysian Society of Infectious Diseases and Chemotherapy (MSIDC), 2023 (National)
- EXCELLENCE SERVICE AWARDUniversity of Malaya, 2023 (University)
- UM-Learning Improvement and Teaching Enhancement Conference (LITEC)Universiti Malaya, 2021 (International)
- CERTIFICATE OF EXCELLENT SERVICEUniversity of Malaya, 2021 (University)
- Gold in the Pharm-IIDEX 2020 - Expanding Frontiers Through Innovative IdeasUITM, 2020 (National)
- Most Innovative Project (FYP Supervisor), 2nd National Pharmacy Research Competition (NPRC)MyPSA , 2019 (National)
- Among Top Scoring Abstracts (Second co-author), American Society for Clinical Pharmacology and Therapeutics Annual Meeting, Washington, D.C.ASCPT, 2019 (International)
- Top 3 Most Active Modules (Module Coordinator), School of Pharmacy, 2018, Taylor's UniversityTaylor's University, 2019 (University)
- Second prize for Poster, Drug Related Problems Identified by Pharmacists in Peritoneal Dialysis Medication Therapy Adherence Clinic (PD-MTAC), Tengku Ampuan Rahimah Hospital, Klang (Co-author), 34th Annual Congress of Malaysian Society of NephrologyMalaysian Society of Nephrology, 2018 (National)
- Winner of 3 Minute Thesis (3MT) Competition for Department of MicrobiologyMonash University, Australia, 2016 (Department)
- Young Investigator Travel Award (attended the 55th Interscience Conference of Antimicrobial Agents and Chemotherapy and the 28th International Congress of Chemotherapy and Infection (ICAAC/ICC), San Diego, United States)International Society of Chemotherapy for Infection and Cancer (ISC) , 2015 (International)
PUBLICATIONS
Article in Journal
WoS
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Ismail, Sophia Rasheeqa; Radzi, Ranina; Kamaruddin, Puteri Sofia Nadira Megat; Lokman, Ezarul Faradianna; Lim, Han Yin; Rahim, Nusaibah Abdul; Yow, Hui Yin; Arumugam, Daarshini; Ngu, Alex; Low, Annie Ching Yi; Wong, Eng Hwa; Patil, Sapna; Madhavan, Priya; Bin Nordin, Ruslin; van der Werf, Esther; Lai, Nai Ming (2024). The effects of school-based hygiene intervention programme: Systematic review and meta-analysis, PLOS ONE. 19(10). doi:10.1371/journal.pone.0308390
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Yow, Hui Yin; Loo, Jason Siau Ee; Lee, Yu Hang; Oui, Hui Che; Zubairi, Megat Helmi Megat Mohd; Rahim, Nusaibah Abdul (2024). A retrospective analysis of e-prescriptions for non-communicable diseases on a telehealth platform in Malaysia, BMC HEALTH SERVICES RESEARCH. 24(1). doi:10.1186/s12913-024-11341-0
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Hanafin, Patrick O.; Rahim, Nusaibah Abdul; Sharma, Rajnikant; Cess, Colin G.; Finley, Stacey D.; Bergen, Phillip J.; Velkov, Tony; Li, Jian; Rao, Gauri G. (2023). Proof-of-concept for incorporating mechanistic insights from multi-omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae, CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY. . doi:10.1002/psp4.12923
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Idris, Nurulain; Leong, Kok Hoong; Wong, Eng Hwa; Rahim, Nusaibah Abdul (2023). Unveiling synergism of polymyxin B with chloramphenicol derivatives against multidrug-resistant (MDR) Klebsiella pneumoniae, JOURNAL OF ANTIBIOTICS. . doi:10.1038/s41429-023-00659-2
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Loo, Jason S. E.; Yow, Hui Yin; Ten, Yi Yang; Govindaraju, Kayatri; Zubairi, Megat Helmi Megat Mohd; Oui, Hui Che; Rahim, Nusaibah Abdul (2023). Exploring the rise of telehealth services in Malaysia: A retrospective study, DIGITAL HEALTH. 9. doi:10.1177/20552076231216275
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Yow, Hui-Yin; Hamzah, Sharina; Suppiah, Vijayaprakash; Abdul Rahim, Nusaibah (2023). Pharmacogenomics of response to statin treatment and susceptibility to statin-induced adverse drug reactions in Asians: a scoping review, ASIAN BIOMEDICINE. 17(3), 95-114. doi:10.2478/abm-2023-0050
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Chung, Wan Yean; Abdul Rahim, Nusaibah; Mahamad Maifiah, Mohd Hafidz; Hawala Shivashekaregowda, Naveen Kumar; Zhu, Yan; Wong, Eng Hwa (2022). In silico genome-scale metabolic modeling and in vitro static time-kill studies of exogenous metabolites alone and with polymyxin B against Klebsiella pneumoniae, FRONTIERS IN PHARMACOLOGY. 13. doi:10.3389/fphar.2022.880352
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Chung, Wan Yean; Zhu, Yan; Mahamad Maifiah, Mohd Hafidz; Hawala Shivashekaregowda, Naveen Kumar; Wong, Eng Hwa; Abdul Rahim, Nusaibah (2022). Exogenous metabolite feeding on altering antibiotic susceptibility in Gram-negative bacteria through metabolic modulation: a review, METABOLOMICS. 18(7). doi:10.1007/s11306-022-01903-w
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Lim, Audrey Huili; Abdul Rahim, Nusaibah; Zhao, Jinxin; Cheung, S. Y. Amy; Lin, Yu-Wei (2022). Cost effectiveness analyses of pharmacological treatments in heart failure, FRONTIERS IN PHARMACOLOGY. 13. doi:10.3389/fphar.2022.919974
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Loh, Jian Sheng; Rahim, Nusaibah Abdul; Tor, Yin Sim; Foo, Jhi Biau (2022). Simultaneous proteasome and autophagy inhibition synergistically enhances cytotoxicity of doxorubicin in breast cancer cells, CELL BIOCHEMISTRY AND FUNCTION. . doi:10.1002/cbf.3704
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Mohd Kamal, Khairunnisa; Mahamad Maifiah, Mohd Hafidz; Zhu, Yan; Abdul Rahim, Nusaibah; Hashim, Yumi Zuhanis Has-Yun; Abdullah Sani, Muhamad Shirwan (2022). Isotopic Tracer for Absolute Quantification of Metabolites of the Pentose Phosphate Pathway in Bacteria, METABOLITES. 12(11). doi:10.3390/metabo12111085
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Yow, Hui-Yin; Govindaraju, Kayatri; Lim, Audrey Huili; Rahim, Nusaibah Abdul (2022). Optimizing Antimicrobial Therapy by Integrating Multi-Omics With Pharmacokinetic/Pharmacodynamic Models and Precision Dosing, FRONTIERS IN PHARMACOLOGY. 13. doi:10.3389/fphar.2022.915355
Scopus
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Jihadi N.I.M., Maifiah M.H.M., Rahim N.A., Sani M.S.A., Hashim Y.Z.H.Y., Kamal K.M. (2022). Combination of polymyxin B and Aquilaria malaccensis extract enhanced the killing and inhibited the growth of Acinetobacter baumannii and Klebsiella pneumoniae, Malaysian Journal of Microbiology. 18(1), 27-36. doi:10.21161/mjm.211241
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Mohd Kamal K., Mahamad Maifiah M.H., Abdul Rahim N., Hashim Y.Z.H.Y., Abdullah Sani M.S., Azizan K.A. (2022). Bacterial Metabolomics: Sample Preparation Methods, Biochemistry Research International. 2022. doi:10.1155/2022/9186536
Others
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Abdul Rahim N, Zhu Y, Cheah SE, Johnson MD, Yu HH, Sidjabat HE, Butler MS, Cooper MA, Fu J, Paterson DL, Nation RL, Boyce JD, Creek DJ, Bergen PJ, Velkov T, Li J. Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo- -Lactamase-Producing Klebsiella pneumoniae Is Predominately Driven by Chloramphenicol. ACS Infect Dis. 2021 Apr 9. doi: 10.1021/acsinfecdis.0c00661.
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Abdul Rahim, N., Cheah, S. E., Johnson, M. D., Zhu, Y., Yu, H., Sidjabat, H. E., . . . Li, J. (2020). Transcriptomic responses of a New Delhi metallo- -lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol. Int J Antimicrob Agents. doi.org/10.1016/j.ijantimicag.2020.106061
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Chung, W. Y., Zhu, Y., Mahamad Maifiah, M. H., Shivashekaregowda, N. K. H., Wong, E. H., Abdul Rahim, N. (2020). Novel antimicrobial development using genome-scale metabolic model of Gram-negative pathogens: a review. J Antibiot. doi.org/10.1038/s41429-020-00366-2.
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Mohd Jihadi, N.I., Has-Yun Hashim, Y.Z., Abdul Rahim, N.,...Mahamad Maifiah, M.H. (2020). Antibacterial activity of ethanolic leaf extract of Aquilaria malaccensis against multidrug-resistant Gram-negative pathogen. Food Research 4 (6) : 1962 - 1968.
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Lin, Y. W., Abdul Rahim, N., Zhao, J., Han, M. L., Yu, H. H., Wickremasinghe, H., . . . Li, J. (2019). Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae. Antimicrob Agents Chemother, 63(4). doi:10.1128/AAC.02176-18.
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Mahamad Maifiah, M. H., Abdullah Sani, M. S., Abdul Rahim, N., 2019, Revisiting an old antibiotic class polymyxins by drug combination therapy targeting Gram-negative superbugs: Toyyiban perspective. J Halal Ind Serv 2019; 2(1): a0000041.
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Abdul Rahim, N., Cheah, S. E., Johnson, M. D., Yu, H., Sidjabat, H. E., Boyce, J., . . . Li, J. (2015). Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol. J Antimicrob Chemother, 70(9), 2589-2597. doi:10.1093/jac/dkv135
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Velkov, T., Abdul Rahim, N., Zhou, Q. T., Chan, H. K., & Li, J. (2015). Inhaled anti-infective chemotherapy for respiratory tract infections: successes, challenges and the road ahead. Adv Drug Deliv Rev, 85, 65-82. doi:10.1016/j.addr.2014.11.004
Article in Proceeding
- Lim, M.Y., Abdul Rahim, N., Periyasamy, P., Lau, C.L., 2019, Assessment of polymyxin B associated nephrotoxicity in ICU patients in a Malaysian tertiary teaching hospital. Malaysian Journal of Medicine and Health Sciences, Vol.15, Supp 2, 4.
- Wong, A.S-L., Abdul Rahim, N., 2019, Effects of phenylpyruvate feeding with polymyxin B in Klebsiella pneumoniae. Malaysian Journal of Medicine and Health Sciences, Vol.15, Supp 2, 5.
Other Publications
- Abdul Rahim, N. (2019). My journey in providing patient care from bedside to bench. Malaysian Pharmaceutical Society Young Pharmacist Chapter. October 2019; Issue 5. - Mps Ypc
- Abdul Rahim, N. (2018). An overview of tension-type headache. MIMS Pharmacy Malaysia. November 2018; 25-30. - Mims
RESEARCH PROJECT
National
- 2023 - 2025, UM International Collaboration GrantInvestigating The Role Of Genetic Polymorphisms Of Ugt1a9 On Pharmacokinetics Of Mycophenolic Acid In Renal Transplant Patients_ ( Co-Researcher)
- 2022 - 2024, Prototype Research Grant Scheme (PRGS)Developing A Model-informed Precision Dosing Antibiotic Top-dose (therapy Optimisation With Precision-dose) Tool To Treat Infectious Diseases ( Principal Investigator(PI))
- 2020 - 2023, RU Geran - Fakulti ProgramOptimising Polymyxin Combination Therapy For Men's Health Related Conditions ( Principal Investigator(PI))
- 2020 - 2022, RU Geran - Fakulti ProgramImproved Delivery Of 5-fluorouracil Loaded In Chitosan-graft-spermine-coated Liposomes For Anti-colorectal Cancer Therapy ( Co-Researcher)
- 2021 - 2022, RU Geran - ADECExploring The Use Of A Student Response System (srs) To Motivate And Instill A Safe Environment For Student Engagement During Online Classes ( Principal Investigator(PI))
- 2019 - 2022, Fundamental Research Grant Scheme (FRGS)Preparation and evaluation of novel allicin-encapsulated 3-D printed microbots for targeting antimicrobial-resistant microbes ( Consultant)
- 2019 - 2021, Fundamental Research Grant Scheme (FRGS)Synergistic antibacterial activity of novel exogenous metabolite-polymyxin combinations against Klebsiella pneumoniae ( Consultant)
- 2019 - 2021, Fundamental Research Grant Scheme (FRGS)Genotyping of SNPs Involved in Pain Control and Adverse Effects of Opioids among Cancer Pain Patients ( Consultant)
- 2019 - 2021, Fundamental Research Grant Scheme (FRGS)Deciphering the mechanism of action of polymyxins on pentose phosphate pathway metabolism in Acinetobacter baumannii in discovering novel antibiotic targets ( Consultant)
- 2018 - 2019, Private FundingOptimizing doripenem and amikacin combination against multi-drug resistant Acinetobacter baumannii using mechanism-based pharmacokinetic/pharmacodynamic modeling ( Principal Investigator(PI))
Private
- 2022 - 2025, Private FundingPerception, Adherence, Clinical, Economical And Health-related Quality Of Life Outcomes Of Careaide App Usage In Chronic Diseases ( Co-Researcher)
- 2022 - 2024, Private FundingExploring Roles And Trends Of Telemedicine And Electronic Prescription Services In Community Pharmacies ( Principal Investigator(PI))
- 2022 - 2024, Private FundingMedication Drone Delivery Research ( Principal Investigator(PI))
International
- 2023 - 2025, International FundingMalaysian Society Of Infectious Diseases & Chemotherapy ( Principal Investigator(PI))
ACADEMIC/PROF. SERVICES
Evaluation
- (2021) Reviewer for Journal Article in Antimicrobial Agents and Chemotherapy (Aac), International, (Reviewer)
- (2021) Reviewer for Journal Article in International Journal of Antimicrobial Agents (Ijaa), International, (Reviewer)
- (2021) Reviewer for Journal Article in International Journal of Peptide Research and Therapeutics (Ijpr), International, (Reviewer)
- (2021) Reviewer for Journal Article in Plos One, International, (Reviewer)
- (2021) Reviewer for Journal Article in International Journal of Antimicrobial Agents (Ijaa), International, (Reviewer)
- (2021) Reviewer for Journal Article in International Journal of Antimicrobial Agents (Ijaa), International, (Reviewer)
- (2021) Reviewer for Journal Article in Plos One, International, (Reviewer)
- (2021) Reviewer for Journal Article in Plos One, International, (Reviewer)
- (2021) Reviewer for Journal Article in Malaysian Journal of Pharmacy, National, (Reviewer)
- (2021) Reviewer for Journal Article in International Journal of Antimicrobial Agents (Ijaa), International, (Reviewer)
- (2021) Reviewer for Journal Article in Malaysian Journal of Pharmacy, National, (Reviewer)
- (2021) Reviewer for Journal Article in Antimicrobial Agents and Chemotherapy (Aac), International, (Reviewer)
- (2021) Reviewer for Journal Article in International Journal of Antimicrobial Agents (Ijaa), International, (Reviewer)
- (2021) Reviewer for Journal Article in International Journal of Antimicrobial Agents (Ijaa), International, (Reviewer)
- (2021) Reviewer for journal article in International Journal of Antimicrobial Agents (IJAA) , (Reviewer)
- (2020) Reviewer for journal article in Frontiers in Microbiology , (Reviewer)
- (2020) Reviewer for journal article in PLOS ONE , (Reviewer)
- (2019) Reviewer for journal article in International Journal of Antimicrobial Agents (IJAA), (Reviewer)
- (2019) Reviewer for journal article in Tropical Biomedicine , (Reviewer)
- (2018) Reviewer for journal article in PLOS Neglected Tropical Diseases , (Reviewer)
- (2017) Reviewer for journal article in International Journal of Antimicrobial Agents (IJAA), (Reviewer)
- (2017) Reviewer for journal article in PLOS ONE , (Reviewer)
Contribution to external organisation
- (2022) Amr Insights Ambassador, International, (Resource Person)
- (2022) Secretary of The International Society of Antimicrobial Chemotherapy (Isac) Early Career Working Group, International, (Resource Person)
- (2022) Industry Advisory Panel for The School of Education, Faculty of Social Sciences and Leisure Management, National, (Expert Advisor)
- (2020) 1st International Conference on Antimicrobial Computational Pharmacology (ICAComP) , Monash University, Melbourne, Australia and University of Konstanz, Konstanz, Germany
- (2019) 1st International Health and Medical Sciences Conference, Taylor's University, Malaysia and Griffith University, Australia
- (2019) Monthly Research Seminar, Faculty of Health & Medical Sciences, Taylor's University
- (2019) APEC CoE Pilot Training on Supply Chain Security for Medical Products, Asia-Pacific Economic Cooperation (APEC) and Taylor's University
- (2018) Antimicrobial PK/PD Workshop "Bringing the Mojo Back to the ICU Bullets - PKPD Style" , Universiti Malaya Medical Centre
- (2018) Faculty of Health & Medical Sciences STEM Day, Taylor's University, University of Dundee and British High Commission Kuala Lumpur
- (2018) Hospital Pharmacy Chapter, Malaysian Pharmaceutical Society
Contribution to event
- (2022) Adjudicator, National, (Panelist/Moderator)
- (2021) Objective Structured Clinical Examination (Osce) Examiner, National, (Panelist/Moderator)
- (2021) Question Provider for 1st Mypsa National Pharmacy Competition - Clinical Pharmacy Challenge, National, (Panelist/Moderator)
- (2021) Judge in The Mypsa Article Writing Competition "Roles of Pharmacists and How to Increase Their Visibility", National, (Panelist/Moderator)
- (2021) Question Provider for The 1st Mypsa Online Inter-University Patient Counselling Skill Event (Pce), National, (Panelist/Moderator)
SUPERVISION
Postgraduate Student
PhD/ Doctoral
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(2024) Optimising Azithromycin Dosing Regimen in Neonates: A Step Towards Model-Informed Precision Dosing, LAM JING KAI
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(2024) FROM THERAPEUTIC DRUG MONITORING TO MODEL-INFORMED PRECISION DOSING FOR AMINOGLYCOSIDES: A FOCUS ON ASIAN POPULATION, ZHENZHEN MOU
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(2022) FROM THERAPEUTIC DRUG MONITORING TO MODEL-INFORMED PRECISION DOSING FOR AMINOGLYCOSIDES: A FOCUS ON ASIAN POPULATION, ZHENZHEN MOU
Master
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(2024) Optimal design of bacteriophage therapy pharmacokinetic (PK) and pharmacodynamic (PD) experiments, Audrey Huili Lim
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(2023) Optimization of Polymyxin B Combinations with Chloramphenicol Derivatives in Combatting Multidrug Resistant (MDR) Klebsiella pneumoniae., NURULAIN BINTI IDRIS
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(2021) Combination of bacteriophage with nanotechnology to enhance phage therapy against Acinetobacter baumannii, Ng Guy Sin (Taylor's University)
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(2020) Deciphering the mechanism of action of polymyxins on pentose phosphate pathway metabolism in Acinetobacter baumannii in discovering novel antibiotic targets, Khairunnisa Binti Mohd Kamal (M0100106)
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(2019) Synergistic antibacterial activity of novel exogenous metabolite-polymyxin B combinations against Klebsiella pneumoniae, Chung Wan Yean
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(2019) Novel Combinations of 'Old' Polymyxin Drug and Medicinal Plant Extracts Targeting Gram-Negative Bacteria Towards Safe Antibiotic, Nurul Izzati Binti Mohd Jihadi
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(2018) Synthesis of 2-Hydroxy-4-Methoxyacetophenone Substituted Chalcones As Potential Antimicrobial And Anticancer Agents, Tan Li Ying (Taylor's University)
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(2018) Investigating the Concept of Doxorubicin-Based Triple-Combination Therapy By Targeting Protein Degradation Pathway, Loh Jian Sheng (Taylor's University)
TEACHING
Bachelor
- (2021) OIA2009 - Basic Immunology and Pharmacotherapy of Immune Disorders
- (2020) OIA1009 - Pharmacotherapy for Eent and Haematological Disorders
- (2020) OIA3014 - Evidence-Based Pharmacotherapy
- (2020) OIA4004 - Hospital and Community Pharmacy Practice
- (2020) OIA4009 - Research Project