Curriculum Vitae

DR. NUR KUSAIRA BINTI KHAIRUL IKRAM

Senior Lecturer
  • Institute of Biological Sciences
    Faculty of Science
  • nkusaira
  • 03-79674366

AREAS OF EXPERTISE

  • PROTOPLAST TECHNOLOGY
    Work with plant-based model organism Physcomitrella patens)
  • GENE TRANSFORMATION
    Gene cloning/expression/purification and moss culture
  • METABOLIC PATHWAYS
    Plant biosynthetic/metabolite pathways, Plant biochemistry, Plant Nutrients, Bioactive properties
  • TRANSGENIC PLANT
    Genetic and Metabolic Engineering for the production of valuable Secondary metabolites

ACADEMIC QUALIFICATION

  • PhD (Biotechnology) (2017), (Biotechnology)
    University of Copenhagen
  • MSc (Healthcare Biotechnology) (2012), (Healthcare Biotechnology)
    Universiti Sains Malaysia (USM)
  • BSc (Hons) (Plant Resource Science and Management) (2008), (Plant Resource Science and Management)
    Universiti Malaysia Sarawak (Unimas)

MEMBERSHIPS

  • EUROPEAN FEDERATION OF BIOTECHNOLOGY, MEMBER
    Since 2019 (International)
  • ASIAN FEDERATION OF BIOTECHNOLOGY, MEMBER
    Since 2019 (International)
  • MALAYSIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY), MEMBER
    2019 to 2024 (National)
  • CENTRE FOR RESEARCH IN BIOTECHNOLOGY FOR AGRICULTURE (CEBAR), MEMBER
    2021 to 2023 (University)
  • MALAYSIAN SOCIETY FOR MOLECULAR BIOLOGY AND BIOTECHNOLOGY, MEMBER
    2019 to 2023 (National)

AWARD AND STEWARDSHIP

  • Certificate of Award & Plaque: Invited Speaker and Panel of Jury at the Third International Seminar on Pharmaceutical Sciences and Technology
    Universitas Padjadjaran, Jatinangor Indonesia, 2018 (International)
  • Anugerah Cemerlang Universiti Malaya (ACUM)
    Universiti Malaya, 2018 (University)
  • Research and Innovation (Gold Medal) IIDEX UiTM 2018
    Universiti Teknologi Mara (UITM), Shah Alam, 2018 (National)
  • Research and Innovation (Gold Medal) EPIC UiTM 2018 (First author)
    Universiti Teknologi Mara Kuala Terengganu, 2018 (National)

PUBLICATIONS

Article in Journal
WoS
  1. Musfiroh, Ida; Kartasasmita, Rahmana E.; Ibrahim, Slamet; Muchtaridi, Muchtaridi; Hidayat, Syahrul; Ikram, Nur Kusaira Khairul (2023). Stability Analysis of the Asiatic Acid-COX-2 Complex Using 100 ns Molecular Dynamic Simulations and Its Selectivity against COX-2 as a Potential Anti-Inflammatory Candidate, MOLECULES. 28(9). doi:10.3390/molecules28093762
  2. Mustapa, Mohammad Adam; Guswenrivo, Ikhsan; Zurohtun, Ade; Ikram, Nur Kusaira Khairul; Muchtaridi, Muchtaridi (2023). Analysis of Essential Oils Components from Aromatic Plants Using Headspace Repellent Method against Aedes aegypti Mosquitoes, MOLECULES. 28(11). doi:10.3390/molecules28114269
  3. Nurhidayah, Wiwit; Widyasari, Eva Maria; Daruwati, Isti; Mahendra, Isa; Subroto, Toto; Khairul Ikram, Nur Kusaira; Muchtaridi, Muchtaridi (2023). Radiosynthesis, Stability, Lipophilicity, and Cellular Uptake Evaluations of [I-131]Iodine-alpha-Mangostin for Breast Cancer Diagnosis and Therapy, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 24(10). doi:10.3390/ijms24108678
  4. Setyawati, Luthfi Utami; Nurhidayah, Wiwit; Ikram, Nur Kusaira Khairul; Fuad, Wan Ezumi Mohd; Muchtaridi, Muchtaridi (2023). General toxicity studies of alpha mangostin from Garcinia mangostana: A systematic review, HELIYON. 9(5). doi:10.1016/j.heliyon.2023.e16045
  5. Zakariya, Ali Muhammad; Saiman, Mohd Zuwairi; Simonsen, Henrik Toft; Ikram, Nur Kusaira Khairul (2023). Current state, strategies, and perspectives in enhancing artemisinin production, PHYTOCHEMISTRY REVIEWS. . doi:10.1007/s11101-023-09897-6
  6. Dewi, Citra; Fristiohady, Adryan; Amalia, Riezki; Khairul Ikram, Nur Kusaira; Ibrahim, Sugeng; Muchtaridi, Muchtaridi (2022). Signaling Pathways and Natural Compounds in Triple-Negative Breast Cancer Cell Line, MOLECULES. 27(12). doi:10.3390/molecules27123661
  7. Khutami, Chindiana; Sumiwi, Sri Adi; Khairul Ikram, Nur Kusaira; Muchtaridi, Muchtaridi (2022). The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23(4). doi:10.3390/ijms23042056
  8. Muchtaridi, Muchtaridi; Abdullah, Derif A.; Suhandi, Cecep; Sumiwi, Sri A.; Ikram, Nur Kusaira Khairul (2022). Anti-Inflammatory Activity of Alpinia malaccensis (Burm. f.) Roscoe and Kaempferia galanga L. Rhizome Essential Oil Gel Formulations by Carrageenan Induction Method, SAINS MALAYSIANA. 51(5), 1411-1424. doi:10.17576/jsm-2022-5105-12
  9. Mustapa, Mohammad Adam; Guswenrivo, Ikhsan; Zuhrotun, Ade; Ikram, Nur Kusaira Khairul; Muchtaridi, Muchtaridi (2022). Anti-Breast Cancer Activity of Essential Oil: A Systematic Review, APPLIED SCIENCES-BASEL. 12(24). doi:10.3390/app122412738
  10. Muchtaridi, M., Lestari, D., Ikram, N. K. K., Gazzali, A. M., Hariono, M., & Wahab, H. A. (2021). Decaffeination and Neuraminidase Inhibitory Activity of Arabica Green Coffee (Coffea arabica) Beans: Chlorogenic Acid as a Potential Bioactive Compound. Molecules, 26(11), 11. doi: 10.3390/molecules26113402
  11. Muchtaridi, M., Fauzi, M., Ikram, N. K. K., Gazzali, A. M., & Wahab, H. A. (2020). Natural Flavonoids as Potential Angiotensin-Converting Enzyme 2 Inhibitors for Anti-SARS-CoV-2. Molecules, 25(17), 20. doi: 10.3390/molecules25173980
  12. Sahruzaini, Nurul Amylia; Rejab, Nur Ardiyana; Harikrishna, Jennifer Ann; Khairul Ikram, Nur Kusaira; Ismail, Ismanizan; Kugan, Hazel Marie; Cheng, Acga (2020). Pulse Crop Genetics for a Sustainable Future: Where We Are Now and Where We Should Be Heading, FRONTIERS IN PLANT SCIENCE. 11. doi:10.3389/fpls.2020.00531
  13. Ikram, Nur Kusaira Khairul; Kashkooli, Arman Beyraghdar; Peramuna, Anantha; van der Krol, Alexander R.; Bouwmeester, Harro; Simonsen, Henrik Toft (2019). Insights into Heterologous Biosynthesis of Arteannuin B and Artemisinin in Physcomitrella patens, MOLECULES. 24(21). doi:10.3390/molecules24213822
  14. Ikram, Nur K. B. K.; Simonsen, Henrik T. (2017). A Review of Biotechnological Artemisinin Production in Plants, FRONTIERS IN PLANT SCIENCE. 8. doi:10.3389/fpls.2017.01966
  15. Ikram, Nur Kusaira Binti Khairul; Kashkooli, Arman Beyraghdar; Peramuna, Anantha Vithakshana; van der Krol, Alexander R.; Bouwmeester, Harro; Simonsen, Henrik Toft (2017). Stable Production of the Antimalarial Drug Artemisinin in the Moss Physcomitrella patens, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 5. doi:10.3389/fbioe.2017.00047
Scopus
  1. Lestari D., Sari R.P., Musfiroh I., Megantara S., Praceka M.S., Ikram N.K.K., Muchtaridi (2023). INTERACTIONS OF XANTHONE COMPOUNDS FROM THE MANGOSTEEN (GARCINIA MANGOSTANA L) PERICARPS AGAINST INOS, COX-1, AND COX-2 ENZYME RECEPTORS AS ANTI-INFLAMMATORY, International Journal of Applied Pharmaceutics. 15(1), 186-194. doi:10.22159/ijap.2023v15i1.45861
  2. Muchtaridi, Darmawan M., Elizabeth M., Nurzanah D., Margaretha P., Elaine A.A., Neli, Puspitadewi N., Setyawati L.U., Ikram N.K.K. (2023). INTERACTIONS OF ORTHOSIPHON STAMINEUS COMPOUNDS AGAINST COX-2 AS AN ANTIINFLAMMATORY USING IN SILICO METHODS AND TOXICITY PREDICTION, International Journal of Applied Pharmaceutics. 15(6), 288-296. doi:10.22159/ijap.2023v15i6.48663
  3. Musfiroh I., Kartasasmita R.E., Ibrahim S., Muchtaridi M., Hidayat S., Ikram N.K.K. (2023). Stability Analysis of the Asiatic Acid-COX-2 Complex Using 100 ns Molecular Dynamic Simulations and Its Selectivity against COX-2 as a Potential Anti-Inflammatory Candidate, Molecules. 28(9). doi:10.3390/molecules28093762
  4. Musfiroh I., Sigalingging O.S., Suhandi C., Ikram N.K.K., Megantara S., Muchtaridi M. (2023). IN SILICO STUDY OF SOME FLAVONOID COMPOUNDS AGAINST ACE-2 RECEPTORS AS ANTI-COVID-19, International Journal of Applied Pharmaceutics. 15(4), 225-230. doi:10.22159/ijap.2023v15i4.48109
  5. Zakariya A.M., Saiman M.Z., Simonsen H.T., Ikram N.K.K. (2023). Current state, strategies, and perspectives in enhancing artemisinin production, Phytochemistry Reviews. . doi:10.1007/s11101-023-09897-6
  6. Junaidin J., Lestari D., Kurniawan M.F., Khairul Ikram N.K. (2022). Ligand-based pharmacophore modeling, molecular docking, and molecular dynamic studies of HMG-CoA reductase inhibitors, Informatics in Medicine Unlocked. 32. doi:10.1016/j.imu.2022.101063
  7. Khairul Ikram E.H., Wan Mohd Nasir W.D.N., Khairul Ikram N.K. (2022). Antioxidant Activity and Total Phenolics Content of Brazilian Spinach(Alternantherasissoo)and Spinach Cultivarin Malaysia, Malaysian Journal of Medicine and Health Sciences. 18(8), 221-229. doi:10.47836/mjmhs18.8.29
  8. Khutami C., Sumiwi S.A., Khairul Ikram N.K., Muchtaridi M. (2022). The Effects of Antioxidants from Natural Products on Obesity, Dyslipidemia, Diabetes and Their Molecular Signaling Mechanism, International Journal of Molecular Sciences. 23(4). doi:10.3390/ijms23042056
  9. Balamurugan, J. P., Supramani, S., Ahmad Usuldin, S. R., Ilham, Z., Klaus, A., Khairul Ikram, N. K., . . . Wan-Mohtar, W. A. A. Q. I. (2021). Efficient biomass-endopolysaccharide production from an identified wild-Serbian Ganoderma applanatum strain BGS6Ap mycelium in a controlled submerged fermentation. Biocatalysis and Agricultural Biotechnology, 37. doi: 10.1016/j.bcab.2021.102166
Others
  1. Shahril Efzueni Rozali, Mahanom Jalil, Nur Kusaira Khairul Ikram, Jamilah Syafawati Yaacob, Lim Yen-Theng, Sakthivel Balakrisnan. In Vitro Germination, Callus Induction and Shoot Multiplication of Important Medicinal Plant, Christia Vespertilionis (L.F.) Bakh.F. TEST Engineering and Management. 2020, 83, 6673-6678.
  2. Usuldin, S. R. A., Mahmud, N., Ilham, Z., Ikram, N. K. K., Ahmad, R., & *Wan-Mohtar, W. A. A. Q. I. (2020). In-depth spectral characterization of antioxidative (1, 3)- -D-glucan from the mycelium of an identified tiger milk mushroom Lignosus rhinocerus strain ABI in a stirred-tank bioreactor. Biocatalysis and Agricultural Biotechnology, 23, 101455., doi: https://doi.org/10.1016/j.bcab.2019.101455
  3. King, B. C., Vavitsas, K., Ikram, N. K. B. K., Schr der, J., Scharff, L. B., Bassard, J.- ., . . . Simonsen, H. T. (2016). In vivo assembly of DNA-fragments in the moss, Physcomitrella patens. Scientific reports
  4. Sabovljevi , M. S., Sabovljevi , A. D., Ikram, N. K. K., Peramuna, A., Bae, H., & Simonsen, H. T. (2016). Bryophytes an emerging source for herbal remedies and chemical production. Plant Genetic Resources, 14(4), 314-327.
  5. Yaeghoobi, M., Frimayanti, N., Chee, C. F., Ikram, K. K., Najjar, B. O., Zain, S. M., . . . Rahman, N. A. (2016). QSAR, in silico docking and in vitro evaluation of chalcone derivatives as potential inhibitors for H1N1 virus neuraminidase. Medicinal Chemistry Research, 25(10), 2133-2142.
  6. Ikram, N. K. K., Durrant, J. D., Muchtaridi, M., Zalaludin, A. S., Purwitasari, N., Mohamed, N., . . . Rahman, N. A. (2015). A virtual screening approach for identifying plants with anti H5N1 neuraminidase activity. Journal of chemical information and modeling, 55(2), 308-316.
  7. Ikram, N., Zhan, X., Pan, X.-W., King, B. C., & Simonsen, H. T. (2015). Stable heterologous expression of biologically active terpenoids in green plant cells. Frontiers in plant science, 6, 129.

RESEARCH PROJECT

National
  1. 2020 - 2023, Fundamental Research Grant Scheme (FRGS)
    Bioactive Compounds Recovery and Growth Performance of Castanea sativa Mill. in different environment ( Consultant)

PAPER PRESENTED

CONFERENCE
  1. Enhancement of Saponins Production from Adventitious Roots Culture of Talinum fruticosum (L.) Juss., 12th AFOB Regional Symposium (ARS) 2020, Asian Federation of Biotechnology (AFOB) (International) (09 Feb 2020 - 11 Feb 2020)
INVITED SPEAKER
  1. GREEN PRODUCTION OF PHARMACEUTICALS: THE CASE OF ARTEMISININ, USD Pharmacy International Webinar Series (UPIWeS) 2021, Faculty of Pharmacy, Sanata Dharma University, Yogyakarta , Indonesia (International) (18 Sep 2021 - 19 Sep 2021)
  2. A New Plant-Based Drug Production Platform, 3rd International Seminar on Pharmaceutical Science And Technology, Universitas Padjadjaran (International) (23 Oct 2018 - 24 Oct 2018)
ORAL PRESENTER
  1. In vitro germination, callus induction and shoot multiplication of important medicinal plant, Christia vespertilionis (l.f) Bakh.f., International Conference on Applied Science, Engineering, Technology and Management (ICASETEM-2019), Institute of Engineering Research and Publication (IFERP) (International) (16 Oct 2019 - 17 Oct 2019)
  2. Combining Natural Product and Information Technology to Spearhead Research in Drug Discovery., Bali International Seminar in Science and Technology , Bali, Indonesia (International) (22 Jul 2011 - 23 Jul 2011)
  3. Docking Validation Of Neuraminidase Inhibitors From Plant Natural Product. , The International Seminar and Expo on Jamu 2010 Herbal Medicine: Indigenous, Molecular Aspects and Clinical Application , Universitas Padjadjaran, Bandung Indonesia.  (International) (05 Nov 2010 - 06 Nov 2010)
  4. Structure Based Drug Design for Swine Flu Chemotherapeutics: New Neuraminidase Inhibitors from Plants Natural Compounds. , 14th International Annual Symposium on Computational Science and Engineering, Mah Fah Luang University, Chiang Rai Thailand.  (International) (23 Mar 2010 - 26 Mar 2010)
POSTER PRESENTER
  1. ArteMoss: A novel plant-based malarial drug production system , Asian Federation of Biotechnology- Malaysia Chapter International Symposium 2019, AFOB (International) (21 Oct 2019 - 23 Oct 2019)
  2. Spontaneous production of Arteannuin B in the moss Physcomitrella patens. , Plant Genomic Congress Asia, Global Engage (International) (04 Apr 2016 - 13 Apr 2016)
  3. Metabolite Engineering of The Moss Physcomitrella patens for the production of sesquiterpenoids., TERPNET Meeting 2015, University of British Columbia, Vancouver, Canada.  (International) (01 Jun 2015 - 05 Jun 2015)
  4. Virtual Screening Of Malaysian Plants For H1N1/H5N1 Neuraminidase Inhibition., Eight European Workshop in Drug Design, , Universit degli studi di Siena (International) (22 May 2011 - 28 May 2011)
OTHERS
  1. Dipping sauce from underutilized Carica papaya Linn. pulp and peel, The 3rd Project of Innovation Competition (EPIC), Universiti Teknologi Mara Terengganu (National) (22 Sep 2018 - 22 Sep 2018)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2024) Enhancement of flavonoid production by overexpressing and silencing MYB transcription factors in Boesenbergia rotunda, IMENE TATAR
  2. (2024) PHYTOCHEMICAL AND BIOLOGICAL STUDIES OF Artemisia vulgaris L., ZAKARIYA ALI MUHAMMAD
  3. (2023) ENHANCEMENT OF BIOACTIVE COMPOUNDS PRODUCTION IN THE in vitro MICROPROPAGATION AND FIELD GROWN CULTIVATION OF UNDERUTILIZED CROPS, Talinum triangulare FOR MEDICINAL PURPOSES, SHAHRIL EFZUENI BIN ROZALI
  4. (2021) FUNCTIONAL CHARACTERISATION OF MYB TRANSCRIPTION FACTOR FROM BOESENBERGIA ROTUNDA TO REGULATE THE FLAVONOID BIOSYNTHETIC PATHWAY, WILLIAM CHUNG WEI LAM
  5. (2018) ENHANCEMENT OF BIOACTIVE COMPOUNDS PRODUCTION IN THE in vitro MICROPROPAGATION AND FIELD GROWN CULTIVATION OF UNDERUTILIZED CROPS, Talinum triangulare FOR MEDICINAL PURPOSES, SHAHRIL EFZUENI BIN ROZALI
  6. (2016) Functional characterisation of MYB transcription factor from Boesenbergia rotunda to regulate the flavanoid biosynthetic pathway, William Chung Wei Lam
Master
  1. (2024) Characterisation of prenyltransferase isomers in the flavonoid biosynthetic pathway using Boesenbergia rotunda cell suspension cultures and moss protoplasts, ALICIA NG JIA HUEY
  2. (2021) EXOPOLYSACCHARIDES PRODUCTION FROM WILD SERBIAN Ganoderma applanatum STRAIN (BGS6Ap) MYCELIUM IN A BATCH FERMENTATION, JOSHINI PILLAI A/P BALAMURUGAN
  3. (2019) ISOLATION AND IDENTIFICATION OF MALAYSIAN TIGER MILK MUSHROOM AND CHARACTERIZATION OF ITS MYCELIAL (1,3)-B-D-GLUCAN, SITI ROKHIYAH BINTI AHMAD USULDIN
  4. (2018) PRODUCTION AND BIOACTIVITY OF LIGNOSUS RHINOCERUS EXOPOLYSACCHARIDE USING SUBMERGED LIQUID FERMENTATION, SITI ROKHIYAH AHMAD USULDIN

PATENT/IPR

  • DiPPs
    Copyright (National)