Curriculum Vitae

DR. ZARIF BIN MOHAMED SOFIAN

Senior Lecturer
  • Department of Pharmaceutical Technology
    Faculty of Pharmacy
  • ms_zarif
  • 0198121427

AREAS OF EXPERTISE

  • PHARMACEUTICAL TECHNOLOGY
    Drug Delivery Systems

ACADEMIC QUALIFICATION

  • PHD, (Science Pharmacy)
    King's College, London
  • MSC, (NEUROSCIENCES)
    Universiti Sains Malaysia (USM)
  • BACHELOR OF SCIENCE (HONOURS) (CHEMISTRY), (CHEMISTRY)
    Universiti Sains Malaysia (USM)

ADMINISTRATIVE DUTIES

  • Head of Department
    05 Aug 2023 - present (Department of Pharmaceutical Technology, Faculty of Pharmacy)
  • Head of Unit
    16 Sep 2021 - 06 Sep 2023 (Department of Pharmaceutical Technology, Faculty of Pharmacy)
  • Committee Members
    20 May 2021 - 19 May 2023 (Department of Pharmaceutical Technology, Faculty of Pharmacy)
  • Quality Manager
    01 Nov 2021 - 31 Oct 2022 (Department)
  • Committee Members
    01 Sep 2020 - 31 Aug 2022 (Department of Pharmaceutical Technology, Faculty of Pharmacy)
  • Coordinator
    01 Aug 2020 - 31 Jul 2022 (Department of Pharmaceutical Technology, Faculty of Pharmacy)
  • Industry and Community Liason Officer
    21 Jan 2021 - 20 Jan 2022 (University Malaya)
  • Postgraduate Coordinator
    16 Sep 2019 - 15 Sep 2021 (Department of Pharmaceutical Technology, Faculty of Pharmacy)
  • Coordinator Mobility and Industry Linkage
    01 Aug 2020 - 31 Oct 2020 (Department of Pharmaceutical Technology, Faculty of Pharmacy)
  • Coordinator Postgraduate Program
    30 Sep 2019 - 31 Aug 2020 (Department of Pharmaceutical Technology, Faculty of Pharmacy)
  • Coordinator Certification Unit
    30 Sep 2019 - 31 Aug 2020 (Department of Pharmaceutical Technology, Faculty of Pharmacy)

PUBLICATIONS

Article in Journal
WoS
  1. Chellathurai, Melbha Starlin; Mahmood, Syed; Sofian, Zarif Mohamed; Hee, Cheng Wan; Sundarapandian, Ramkanth; Ahamed, Haja Nazeer; Kandasamy, C. S.; Hilles, Ayah R.; Hashim, Najihah Mohd; Janakiraman, Ashok Kumar (2024). Biodegradable polymeric insulin microneedles - a design and materials perspective review, DRUG DELIVERY. 31(1). doi:10.1080/10717544.2023.2296350
  2. Ibrahim, Intan Shazleen; Chellathurai, Melbha Starlin; Mahmood, Syed; Azmi, Amirul Hakim; Harun, Norsyifa; Nazri, Mohd Ulul Ilmie Ahmad; Mahat, Mohd Muzamir; Sofian, Zarif Mohamed (2024). Engineered liposomes mediated approach for targeted colorectal cancer drug Delivery: A review, INTERNATIONAL JOURNAL OF PHARMACEUTICS. 651. doi:10.1016/j.ijpharm.2023.123735
  3. Chellathurai, Melbha Starlin; Yong, Chung Lip; Sofian, Zarif Mohamed; Sahudin, Shariza; Hasim, Najihah Binti Mohd; Mahmood, Syed (2023). Self-assembled chitosan-insulin oral nanoparticles-A critical perspective review, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 243. doi:10.1016/j.ijbiomac.2023.125125
  4. Khalid, Ramsha; Mahmood, Syed; Mohamed Sofian, Zarif; Hilles, Ayah R.; Hashim, Najihah Mohd; Ge, Yi (2023). Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs-A Review, PHARMACEUTICS. 15(8). doi:10.3390/pharmaceutics15082029
  5. Harun, Norsyifa; Kamaruzaman, Nur Azzalia; Sofian, Zarif Mohamed; Hassan, Zurina (2022). Mini review: Potential therapeutic values of mitragynine as an opioid substitution therapy, NEUROSCIENCE LETTERS. 773. doi:10.1016/j.neulet.2022.136500
  6. Johari, I. S., Harun, N., Sofian, Z. M., & Shoaib, M. (2021). Pentylenetetrazol-like stimulus is not produced following naloxone-precipitated mitragynine withdrawal in rats. Psychopharmacology, 238(11), 3183-3191. doi: 10.1007/s00213-021-05934-4
  7. Ruzaidi, D. A. A., Mahat, M. M., Shafiee, S. A., Sofian, Z. M., Sabere, A. S. M., Ramli, R., . . . Sadasivuni, K. K. (2021). Advocating Electrically Conductive Scaffolds with Low Immunogenicity for Biomedical Applications: A Review. Polymers, 13(19), 26. doi: 10.3390/polym13193395
  8. Ruzaidi, D. A. A., Mahat, M. M., Sofian, Z. M., Hashim, N. A. N., Osman, H., Nawawi, M. A., . . . Hamzah, H. H. (2021). Synthesis and Characterization of Porous, Electro-Conductive Chitosan-Gelatin-Agar-Based PEDOT: PSS Scaffolds for Potential Use in Tissue Engineering. Polymers, 13(17), 20. doi: 10.3390/polym13172901
  9. Sofian, Z. M., Harun, N., Mahat, M. M., Hashim, N. A. N., & Jones, S. A. (2021). Investigating how amine structure influences drug-amine ion-pair formation and uptake via the polyamine transporter in A549 lung cells. European Journal of Pharmaceutics and Biopharmaceutics, 168, 53-61. doi: 10.1016/j.ejpb.2021.08.003
  10. Sofian, Zarif M.; Benaouda, Faiza; Wang, Julie Tzu-Wen; Lu, Yuan; Barlow, David J.; Royall, Paul G.; Farag, Doaa B.; Rahman, Khondaker Miraz; Al-Jamal, Khuloud T.; Forbes, Ben; Jones, Stuart A. (2020). A Cyclodextrin-Stabilized Spermine-Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency, ADVANCED THERAPEUTICS. 3(12). doi:10.1002/adtp.202000153
ESCI
  1. Omar, Siti Nurzatul Ikma; Zainal Ariffin, Zaidah; Zakaria, Azlan; Safian, Muhd Fauzi; Abd Halim, Mohamed Izzharif; Ramli, Rosmamuhamadani; Sofian, Zarif Mohamed; Zulkifli, Meor Faisal; Aizamddin, Muhammad Faiz; Mahat, Mohd Muzamir (2020). Electrically conductive fabric coated with polyaniline: physicochemical characterisation and antibacterial assessment, EMERGENT MATERIALS. 3(4), 469-477. doi:10.1007/s42247-019-00062-4
Others
  1. Ahmad Ruzaidi, D. A., Mahat, M. M., Mohamed Sofian, Z., Nor Hashim, N. A., Osman, H., Nawawi, M. A., Ramli, R., et al. (2021). Synthesis and Characterization of Porous, Electro-Conductive Chitosan Gelatin Agar-Based PEDOT: PSS Scaffolds for Potential Use in Tissue Engineering. Polymers, 13(17), 2901. MDPI AG. Retrieved from http://dx.doi.org/10.3390/polym13172901
  2. Dania Adila Ahmad Ruzaidi, Mohd Muzamir Mahat, Saiful 'Arifin Shafiee, Zarif Mohamed Sofian, Awis Sukarni Mohamad Sabere, Rosmamuhamadani Ramli, Hazwanee Osman, Hairul Hisham Hamzah, Zaidah Zainal Ariffin, Kishor Kumar Sadasivuni (2021) Advocating electrically conductive scaffolds with low immunogenicity for biomedical application: A review. Polymers. 13, 3395.
  3. Zarif M. Sofian, Faiza Bebaouda, Julie Tzu-Wen Wang, Yuan Lu, David J. Barlow, Paul G.Royall, Doaa B. Farag, Khondaker Miraz Rahman, Khuloud T. Al-Jamal, Ben Forbes, Stuart A. Jones (2020) A cyclodextrin-stabilized spermine-tagged drug triplex that targets theophylline to the lungs selectively in respiratory emergency. Advanced Therapeutics - accepted.
  4. Zarif MS, Shazrin SS, Jafri MA, Hasnah O, Shariza AR (2014) Evaluation of the Cytotoxicity of Levodopa and its Complex with Hydroxypropyl-Beta-Cyclodextrin (HP-B-CD) to an Astrocyte Cell Line. Malaysian Journal of Medical Sciences. 21(Spec Issue): 6 11.
  5. Zarif MS, Afidah AR, Abdullah JM, Shariza AR (2012) Physicochemical characterization of vancomycin and its complexes with B-cyclodextrin. Biomedical Research. 23 (4): 513-520.
  6. Zarif MS, Jafri MA, Afidah AR, Shazrin SS, Zulkifli M, Shariza AR (2012) Cytotoxicity evaluation of vancomycin and its complex with beta-cyclodextrin on human glial cell line. Pakistan Journal of Pharmaceutical Science. 25 (4): 831-837
Chapter in Books
  1. MS Chellathurai, S Mahmood, ZM Sofian, NBM Hashim (2023) Emerging Applications of Polymers in Biomedical and Pharmaceutical Fields. Specialty Polymers. 327-343.
Article in Proceeding
  1. Zurina H, Zarif MS, Visweswaran N (2012) Changes in the spontaneous EEG and locomotor activity of freely moving rats in mitragynine-treated animals. ACNS-2012 Australasian Cognitive Neuroscience Conference. doi: 10.3389/conf. fnhum
Other Publications
  1. Zarif MS, Julie TWW, Yuan L, Paul R, Ben F, David JB, CP, Khuloud TA, Stuart J, Faiza B (2019) Cyclodextrin-stabilised ion-pair complexes enhance drug lung uptake via polyamine transporter. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 32(2):A11 - Extended Abstract
  2. Zarif MS, Arcadia W, Paul GR, Stuart AJ (2017) Polyamine ion-pairs to target drugs to the lung. Journal of Aerosol Medicine and Pulmonary Drug Delivery. 30(4):A6 - Extended Abstract

RESEARCH PROJECT

National
  1. 2022 - 2024, Others MOHE - Top 100 (IIRG)-FNW
    WP1: Development of Novel Therapeutic Agent and Delivery Method for Lung Cancer ( Principal Investigator(PI))
  2. 2020 - 2023, RU Geran - Fakulti Program
    Optimising Polymyxin Combination Therapy For Men's Health Related Conditions ( Co-Researcher)
  3. 2020 - 2023, RU Geran - Fakulti Program
    Identification Of Influential Gene Cluster Network And In Silico Molecular Mechanism Of Action Of Melittin In Oscc ( Co-Researcher)
  4. 2020 - 2022, RU Geran - Fakulti Program
    Improved Delivery Of 5-fluorouracil Loaded In Chitosan-graft-spermine-coated Liposomes For Anti-colorectal Cancer Therapy ( Principal Investigator(PI))
  5. 2021 - 2023, Skim Geran Penyelidikan Fundamental (FRGS)
    Mechanism of electronic conduction of electrospun PEDOT:PSS: X-ray photoelectron spectroscopy (XPS) and density functional theory (DFT) analysis, Ministry of Higher Education ( Co-Researcher)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2021) Penilai Teknikal dan Harga Bagi Tawaran Perolehan Sebutharga, University, (Internal Evaluator)
  2. (2021) Internal Evaluator, University, (Internal Evaluator)
  3. (2020) Internal Examiner for a MMedSc Thesis entitled "Formulation Design and Optimization of Orodispersible Tablets of Vardenafil Hydrochloride Tryhidate" - Mr Gan Kok Zheng , (Internal Examiner)
  4. (2020) Chairperson and Assessor for Seminar Before Thesis Submission. A PhD Thesis entitled "Clinical and Genetic Association of Insulin Resistance and Multi-Vessel Stenosis in Type 2 Diabetes Mellitus Patients With Coronary Artery Disease" - Ms Sangeetha A/P Perumalsamy , (Assessor)
  5. (2020) Chairperson and Assessor for Seminar Before Thesis Submission. A PhD Thesis entitled "Apoptotic Induction Mechanism of Artonin E and Pyranocycloartobiloxanthane A on Ovarian Cancer Cells" - Ms Mashitoh Abd Rahman , (Assessor )
  6. Reviewer for an article entitled Newborn Screening of Tyrosinemia Type I by Quantitative Determination of Succinyl Acetone in Dried Blood Spot Samples - Malaysian Journal of Biochemistry & Molecular Biology (MJBMB). , (Reviewer)
Contribution to external organisation
  1. (2020) Fundamental Research Grant Scheme 2020, Faculty of Pharmacy
  2. (2020) Curriculum Committee for Faculty of Pharmacy, Faculty of Pharmacy

SUPERVISION

Postgraduate Student
  1. (2024) Fabrication and evaluation of layer by layer coated Insulin nanoparticles Infused in microneedle for oral delivery, MELBHA STARLIN CHELLATHURAI
  2. (2024) Evaluating The Potential Of Chitosan/Spermine (CHI/SPE)-Decorated LiposomesTo Enhance The Therapeutic Efficacy Of 5-Fluorouracil (5FU) In Colorectal Cancer Cells, Intan Shazleen Ibrahim
  3. (2024) Physicocemical characterization and antibacterial studies of curcumin/cyclodextrin bound silver nanoparticles (cAgNP), AMIRUL HAKIM BIN AZMI
Under Graduate Students
  1. (2021) Research Project

TEACHING

Doctor Of Philosophy
  1. (2021) OVA8001 - Research Methodology
Master
  1. (2021) OMX7001 - Research Methodology
Bachelor
  1. (2021) OIA2003 - Pharmaceutical Dosage Form Design for Liquids and Semi-Solids
  2. (2021) OIA3017 - Pharmaceutical Product Development
  3. (2021) OIA1008 - Physical Pharmacy
  4. (2021) OIA4009 - Research Project
  5. (2020) OIA1002 - Pharmaceutical Organic Chemistry
  6. (2020) OIA1008 - Physical Pharmacy
  7. (2020) OIA2003 - Pharmaceutical Dosage Form Design for Liquids and Semi-Solids
  8. (2020) OIA3010 - Advanced Pharmaceutical Dosage Form Design
  9. (2020) OIA4001 - Pharmaceutical Quality Assurance
  10. (2019) OIA1008 - Physical Pharmacy
  11. (2019) OIA3016 - Professional Pharmacy Attachment
  12. (2019) OIA3017 - Pharmaceutical Product Development