Curriculum Vitae

DR. MOHAMAD SHAFIQ BIN AZANAN

Senior Lecturer
  • Department of Paediatrics
    Faculty of Medicine
  • mohamadshafiq
  • 03-79496376

BIOGRAPHY

Dr Mohamad Shafiq is a Senior Lecturer at the Department of Paediatrics, Faculty of Medicine, Universiti Malaya. He holds a Bachelor of Science degree, majoring in Biotechnology, specializing in cellular, molecular, and developmental biology, from the University of Melbourne, Australia. He completed his Honours Year for a project on skeletal developmental disease at the Murdoch Children's Research Institute and the Royal Children Hospital, Melbourne. He then obtained his Ph.D. from Universiti Malaya in 2019 for his research on the role of immune derangements in the late effects of childhood cancer survivors. Currently his research topics involved haematology-oncology, ageing and paediatric research. He is also the consultants and collaborates in many projects that involved flow cytometry.

AREAS OF EXPERTISE

  • FLOW CYTOMETRY
  • MOLECULAR AND STRUCTURAL BIOLOGY
  • DIAGNOSTICS
  • CELLULAR IMMUNOLOGY

ACADEMIC QUALIFICATION

  • Doctoral Degree (PhD), (Pediatrik)
    Universiti Malaya (UM)
  • BACHELOR OF SCIENCE (DEGREE WITH HONOURS), (Biotechnology)
    University of Melbourne, Australia

ADMINISTRATIVE DUTIES

  • Head of Unit
    09 Mar 2021 - 31 Dec 2022 (Dean Office, Faculty of Medicine)
  • Committee Member of the Task Force for Research Procurement Workflow, Research Office, Faculty of Medicine
    01 Aug 2021 - 30 Jul 2022 (Faculty)
  • Committee member for Department of Paediatrics website
    21 Jan 2021 - 31 Dec 2021 (Department of Paediatrics, Faculty of Medicine)
  • Research Communication Unit, Research Office, Faculty of Medicine
    01 Apr 2020 - 31 Dec 2021 (Dean Office, Faculty of Medicine)
  • Panel Jawatankuasa Penilaian & Pemantauan Geran Penyelidikan (JPPGP)
    01 Jan 2020 - 31 Dec 2021 (Department of Paediatrics, Faculty of Medicine)
  • Research Coordinator
    01 Jan 2020 - 31 Dec 2020 (Department of Paediatrics, Faculty of Medicine)

MEMBERSHIPS

  • MEMBER OF THE INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY, MEMBER
    2022 to 2023 (International)
  • INTERNATIONAL CLINICAL CYTOMETRY SOCIETY, MEMBER
    2021 to 2022 (International)
  • INTERNATIONAL SOCIETY FOR ADVANCEMENT OF CYTOMETRY, MEMBER
    2021 to 2021 (International)

AWARD AND STEWARDSHIP

  • Best Poster
    Malaysian Society of Paediatric Haematology-Oncology, 2019 (National)
  • Best Overall Poster
    11th St. Jude-VIVA Forum in Paediatric Oncology, 2017 (International)
  • Best Overall Poster
    10th St. Jude-Viva Forum in Paediatric Oncology, 2016 (International)
  • UMSC Fund C.A.R.E Award - Short term training
    UMSC C.A.R.E, 2016 (University)
  • Best Poster
    Malaysian Society of Paediatric Haematology-Oncology - 20th Annual Scientific Meeting, 2015 (National)
  • Best Poster
    Malaysian Society of Paediatric Haematology-Oncology - 19th Annual Scientific Meeting, 2014 (National)

PUBLICATIONS

Article in Journal
WoS
  1. Al-Haroni, Hanan; Farid, Nik Daliana Nik; Azanan, Mohamad Shafiq (2024). Effectiveness of education intervention, with regards to physical activity level and a healthy diet, among Middle Eastern adolescents in Malaysia: A study protocol for a randomized control trial, based on a health belief model, PLOS ONE. 19(1). doi:10.1371/journal.pone.0289937
  2. Abdullah, Asmaa' Hazirah; Nathan, Anna Marie; Jayanath, Subhashini; Kwan, Zhenli; Azanan, Mohamad Shafiq; Hng, Shih Ying; Eg, Kah Peng; de Bruyne, Jessie A.; Leong, Kin Fon; Wee, Ai Leen; Ponnuthurai, Nirmala; Begum, Sabeera (2023). Poor sleep quality in children with atopic dermatitis and its effects on behavior: A multicenter cross-sectional study from a low-middle-income country, PEDIATRICS INTERNATIONAL. 65(1). doi:10.1111/ped.15473
  3. Chua, Ling L.; Azanan, Mohamad S.; Oh, Lixian; Ariffin, Hany (2023). Physical Inactivity as an Early Sign of Frailty in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia, JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. 45(5), E560-E566. doi:10.1097/MPH.0000000000002586
  4. Lai, Charles Dekun; Marret, Mary J.; Jayanath, Subhashini; Azanan, Mohamad Shafiq (2023). Abusive head trauma in infants: An observational single centre study comparing developmental and functional outcome between 18 months and 5 years, CHILD ABUSE & NEGLECT. 145. doi:10.1016/j.chiabu.2023.106434
  5. Oh, Lixian; Ab Rahman, Syaza; Dubinsky, Kailey; Azanan, Mohamad Shafiq; Ariffin, Hany (2023). Manipulating the Gut Microbiome as a Therapeutic Strategy to Mitigate Late Effects in Childhood Cancer Survivors, TECHNOLOGY IN CANCER RESEARCH & TREATMENT. 22. doi:10.1177/15330338221149799
  6. Chandrasekaran, S., Ramli, N., Ahmad, M. J., Effendi, I., Amir, N. N., Chow, R. C., . . . Kamalden, T. A. (2021). Premature Ocular Aging Features in Childhood Acute Lymphoblastic Leukemia Survivors. Journal of Adolescent and Young Adult Oncology, 10(4), 425-431. doi: 10.1089/jayao.2020.0064
  7. Azanan, M. S., Chandrasekaran, S., Rosli, E. S., Chua, L. L., Oh, L., Chin, T. F., . . . Ariffin, H. (2020). Retinal Vessel Analysis as a Novel Screening Tool to Identify Childhood Acute Lymphoblastic Leukemia Survivors at Risk of Cardiovascular Disease. Journal of Pediatric Hematology Oncology, 42(6), E394-E400. doi: 10.1097/mph.0000000000001766
  8. Chew, N., Azhar, A. M. N., Bustam, A., Azanan, M. S., Wang, C., & Lum, L. C. S. (2020). Assessing dehydration status in dengue patients using urine colourimetry and mobile phone technology. PLoS neglected tropical diseases, 14(9), 12. doi: 10.1371/journal.pntd.0008562
Scopus
  1. See J.K., Jayanath S., Azanan M.S. (2022). SCREEN TIME AND LANGUAGE DELAY IN CHILDREN: A CROSS-SECTIONAL STUDY IN A SOUTHEAST ASIAN COUNTRY, Journal of Health and Translational Medicine. 25(2), 104-113. doi:10.22452/jummec.vol25no2.17
Others
  1. Chandrasekaran S, Ramli N, Jamaluddin Ahmad M, Effendi I, Amir NN, Chow RC, Chee CKL, Azanan MS, Abd Ghafar SS, Ariffin H, Kamalden TA. Premature Ocular Aging Features in Childhood Acute Lymphoblastic Leukemia Survivors. J Adolesc Young Adult Oncol. 2020 Sep 30. doi: 10.1089/jayao.2020.0064. Epub ahead of print. PMID: 32996803.
  2. Chin TF, Ibrahim K, Thirunavakarasu T, et al. Nonclonal Chromosomal Aberrations in Childhood Leukemia Survivors. Fetal and Pediatric Pathology. 2018 Aug;37(4):243-253. DOI: 10.1080/15513815.2018.1492054.
  3. Ariffin H, Azanan MS, Abd Ghafar SS, et al. Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging. Cancer. 2017;123(21):4207 4214. doi:10.1002/cncr.30857
  4. Chua LL, Rajasuriar R, Azanan MS, Abdullah NK, Tang MS, Lee SC, Woo YL, Lim YA, Ariffin H, Loke P.. Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation. Microbiome. 2017;5(1):35.
  5. Azanan MS, Abdullah NK, Chua LL, Lum SH, Abdul Ghafar SS, Kamarulzaman A, Kamaruzzaman S, Lewin SR, Woo YL, Ariffin H, Rajasuriar R. Immunity in young adult survivors of childhood leukemia is similar to the elderly rather than age-matched controls: Role of cytomegalovirus. Eur J Immunol. 2016 Jul;46(7):1715-26

RESEARCH PROJECT

National
  1. 2024 - 2027, Fundamental Research Grant Scheme (FRGS)
    Unraveling Hifs-p53 Isoforms-cancer Stem Cell Plasticity Axis In Response To Hypoxic Reprogramming In 3d Tumourspheres Of Hepatocellular Carcinoma ( Co-Researcher)
  2. 2021 - 2025, Fundamental Research Grant Scheme (FRGS)
    Mechanistic Insights Into Wild-type P53 Activity In Childhood Cancers, Using In Silico Prediction And In Vitro Modelling ( Co-Researcher)
  3. 2022 - 2025, Fundamental Research Grant Scheme (FRGS)
    Mitigation Of Accelerated Immunologic Ageing In Childhood Cancer Survivors By Increasing Nicotinamide Adenine Dinucleotide (NAD+) Bioavailability For Sirtuin 1 Through CD38 Catalytic Inhibition ( Principal Investigator(PI))
  4. 2023 - 2025, Bantuan Khas Penyelidikan (BKP Special)
    Biomarkers for Early Identification of Preterm Newborns at Risk for Cerebral Palsy and Neurodevelopmental Delay: The PRIMED Study (PeRinatal InflamMation and nEuro Development) ( Co-Researcher)
  5. 2021 - 2024, International Funding
    Match 2021: P53 Isoforms In Childhood Cancers ( Co-Researcher)
  6. 2020 - 2022, MOSTI-International Collaboration Fund (ICF)
    Maspore-all 2020: Improving Risk Assignment And Treatment Outcome In Childhood Acute Lymphoblastic Leukaemia Through Precision Medicine And Immunotherapy ( Co-Researcher)
  7. 2019 - 2021, Others MOHE - Top 100 (IIRG)-HWB
    Improving Survival Quality Of Childhood Cancer Via Lifestyle Modifications ( Co-Researcher)
  8. 2019 - 2020, Partnership Grant
    Immune and Cellular Therapies for Childhood Cancers ( Co-Researcher)
  9. 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness)
    Elucidating The Aetiology Of Second Cancers In Childhood Cancer Survivors ( Co-Researcher)
  10. 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness)
    P53 Isoforms As New Therapeutic Target In Childhood Cancers ( Co-Researcher)
  11. 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness)
    Personalized Thiopurine Dosing In Children With Acute Lymphoblastic Leukemia (all) Using Tpmt And Nudt15 Genotype Status ( Co-Researcher)

CONSULTANCY PROJECT

  • Central Research Laboratories (Crl) Expert Partner for Bd Facs Canto Ii Flowcytometer & Bd Facs Aria III Cell Sorter At Medical Biotechnology Laboratory (Mbl), Faculty of Medicine
    01 Nov 2020 - 01 Nov 2021 (National)

PAPER PRESENTED

INVITED SPEAKER
  1. Inflammaging and premature aging in children surviving childhood leukemia, 17th Malaysian Society of Haematology Scientific Meeting, Malaysian Society of Haematology (National) (10 Sep 2020 - 12 Sep 2020)
  2. Why should you consider postgraduate study?, Translational Core Laboratory Career Day 2019, Translational Core Laboratory, Faculty of Medicine, University of Malaya (University) (25 Apr 2019 - 25 Apr 2019)
  3. Accelerated Cellular Ageing in Childhood Cancer Survivors, Faculty of Medicine Research Week: Paediatrics and Child Health, Faculty of Medicine, University of Malaya (University) (10 Jul 2017 - 14 Jul 2017)
  4. Mechanism of Late Effects in Childhood Cancer Survivors, UM FOM 4th Science Cafes, Faculty of Medicine (University) (12 Apr 2016 - 12 Apr 2016)
ORAL PRESENTER
  1. Inflammatory plasma cytokines and metabolic syndrome in young adult survivors of childhood leukemia, 16th TNF Superfamily Meeting, TNF Superfamily  (International) (17 Apr 2017 - 20 Apr 2017)
POSTER PRESENTER
  1. Development of a Flow Cytometric Assay for Rapid Screening of Primary Haemophagocytic Lymphohistiocytosis, 24th Annual Scientific Meeting, Malaysian Society of Paediatric Haematology-Oncology  (National) (03 Aug 2019 - 04 Aug 2019)
  2. Clinical Characteristics, Prognostic factors and Treatment outcome of Paediatric Hemophagocytic Lymphohistiocytosis:15-Year Experience at a Single Tertiary Center in Malaysia, 24th Annual Scientific Meeting, Malaysian Society of Paediatric Haematology-Oncology  (National) (03 Aug 2019 - 04 Aug 2019)
  3. Retinal Vessel Analysis: A Novel Screening Tool to Identify Childhood Cancer Survivors (CCS) with Risk of Cardiovascular Disease, 13th St. Jude-VIVA Forum in Paediatric Oncology, St. Jude-VIVA (International) (02 Mar 2019 - 03 Mar 2019)
  4. Exploring the relationship between GSTT1 and GSTM1 genotype status and hepatic veno-occlusive disease in Malaysian children following busulfan-based conditioning therapy for haematopoietic stem cell transplantation, 23rd Annual Scientific Meeting, Malaysian Society of Paediatric Haematology-Oncology (National) (04 Aug 2018 - 05 Aug 2018)
  5. Reduced physiologic reserve parallels cellular aging in asymptomatic childhood cancer survivors aged , 12th St. Jude-VIVA Forum in Paediatric Oncology, St. Jude-VIVA (International) (10 Mar 2018 - 11 Mar 2018)
  6. Role of Cytomegalovirus (CMV) in Immunological Aging in Young Adult Survivors of Childhood Leukemia, Biology of Ageing Conference, Singapore Immunology Network, A*STAR (International) (14 Nov 2017 - 16 Nov 2017)
  7. Inflammatory plasma cytokines and metabolic syndrome in young adult survivors of childhood leukemia, 16th TNF Superfamily Meeting, TNF Superfamily (International) (17 Apr 2017 - 20 Apr 2017)
  8. Cardiovascular ageing in childhood cancer survivors correlates with anthracycline and radiotherapy exposure, 11th St. Jude-VIVA Forum in Paediatric Oncology, St. Jude-VIVA (International) (04 Mar 2017 - 05 Mar 2017)
  9. Young adult survivors of childhood lekaemia demonstrate evidence of genomic instability, 10th St. Jude-VIVA Forum in Paediatric Oncology, St. Jude-VIVA (International) (05 Mar 2016 - 06 Mar 2016)
  10. Renal Late-effects in Long-term Survivors of Childhood Leukemia, 20th Annual Scientific Meeting, Malaysian Society of Paediatric Haematology-Oncology  (National) (05 Sep 2015 - 06 Sep 2015)
  11. Vascular Dysfunction in Young Adult Survivors of Childhood Leukemia is Associated with Immune Activation and Inflammation, 20th Annual Scientific Meeting, Malaysian Society of Paediatric Haematology-Oncology (National) (05 Sep 2015 - 06 Sep 2015)
  12. Genomic Instability in Survivors of Childhood Leukemia: A Precursor of Second Malignant Neoplasms?, 19th Annual Scientific Meeting, Malaysian Society of Paediatric Haematology-Oncology (National) (05 Sep 2015 - 06 Sep 2015)
  13. An Immune Phenotype of Aging in Young Adult Survivors of Childhood Leukemia (ALL), 14th International Conference on Long-term Complications of Treatment of Children and Adolescents for Cancer, St Jude Children's Research Hospital (International) (11 Jun 2015 - 13 Jun 2015)
  14. Survivors of Childhood Lymphoblastic Leukemia Show Evidence of Treatment-related Co-morbidities, 9th St. Jude-VIVA Forum in Paediatric Oncology, St. Jude-VIVA (International) (26 Mar 2015 - 29 Mar 2015)
PRESENTER
  1. A case study of a boy with primary immunodeficiency in UMMC, 23rd Annual Scientific Meeting, Malaysian Society of Paediatric Haematology-Oncology  (National) (04 Aug 2018 - 05 Aug 2018)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2022) Thesis Seminar: Immunotherapy for Prevention and Treatment of Oral Potentially Malignant Lesion (Opmd) and Oral Squamous Cell Carcinoma (Oscc), University, (Internal Assessor)
  2. (2022) Thesis Seminar: Identification of Microrna and Mrnas Associated With R-Chop Chemotherapy Resistance and Disease Progression in Patients With Diffuse Large B-Cell Lymphoma, University, (Internal Assessor)
  3. (2022) 3 Minute Thesis (3mt) for Faculty of Medicine, University, (Internal Evaluator)
  4. (2021) Identification of Long Non-Coding Rna Hub Gene Involved in Glioblastoma Multiforme Lipid Metabolism, University, (Internal Examiner)
  5. (2021) Panel Penemuduga Ijazah Sarjana Muda Fakulti Perubatan Ambilan 2021/22, University, (Internal Assessor)
  6. (2020) Pediatric Hematology Oncology Journal , (Reviewer)
  7. (2020) Candidature Defence for Ting Choo Yuen: Dysregulated microRNA Expression in R-CHOP Resistance/ Early Relapse of Diffuse Large B-Cell Lymphoma , (Internal Examiner)
  8. (2020) Journal of Adolescent and Young Adult Oncology (JAYAO) , (Reviewer)

SUPERVISION

Postgraduate Student
  1. (2024) MITIGATION OF ACCELERATED IMMUNOLOGIC AGEING IN CHILDHOOD CANCER SURVIVORS BY INCREASING NICOTINAMIDE ADENINE DINUCLEOTIDE (NAD+) BIOAVAILABILITY FOR SIRTUIN 1 THROUGH CD38 CATALYTIC INHIBITION, AMIRAH NABILAH BINTI ABDULLAH @ ZAKARIA
  2. (2024) The effectiveness of a knowledge-based health promotion intervention on health risk behavior of Middle Eastern adolescents in Malaysia, HANAN HASAN HUSSEIN AL-HARONI
  3. (2023) Mitigation Of Accelerated Immunologic Ageing In Childhood Cancer Survivors By Increasing Nicotinamide Adenine Dinucleotide (NAD+) Bioavailability For Sirtuin 1 Through CD38 Catalytic Inhibition., CHENGEBROYEN NEEVASHINI

TEACHING

Doctor Of Philosophy
  1. (2023) MVX8001 - Research Methodology
  2. (2022) MVX8001 - Research Methodology
Master
  1. (2023) MQF7006 - Ethical Issues in Global Health Research and Clinical Trials
  2. (2023) MMX7001 - Research Methodology
  3. (2022) MMX7001 - Research Methodology
  4. (2022) MQF7006 - Ethical Issues in Global Health Research and Clinical Trials
  5. (2021) MMX7001 - Research Methodology
  6. (2020) MOFSC - Master of Orofacial Science (Mahsa University)
  7. (2019) MGH - Master of Paediatrics (Intensive Course)
Bachelor
  1. (2023) MIC1014 - Immunology
  2. (2022) MIC1014 - Immunology
  3. (2022) MIC4002 - Biomedical Science Horizons
  4. (2022) NA - Pbl Block 6 Hematology
  5. (2022) MIC1008 - Genetics and Developmental Biology
  6. (2022) MIC2010 - Immunology for Biomedical Science
  7. (2021) UMMP PBL - Block 5 Respiratory Sciences
  8. (2021) UMMP PBL - Block 6 Haematology
  9. (2021) MIC1008 - Genetics and Developmental Biology
  10. (2021) MIC4002 - Biomedical Science Horizons
  11. (2021) MIC2010 - Immunology for Biomedical Science
  12. (2020) MIC4002 - Biomedical Science Horizons
  13. (2020) MIC4002 - Biomedical Science Horizons
  14. (2020) UMMP2601 - University Malaya Medical Programme Block 6 Haematology

SOCIAL RESPONSIBILITY ACTIVITIES

  • International Tutor for The Ask Alumni Programme, (27 Aug 2020 - 31 Dec 2022) (International)
  • Organizing Committee for Bridging Translational Cancer Research Forum in Conjunction With The World Cancer Day, (03 Mar 2020 - 03 Mar 2020)
  • Promotion Committee (Local and International) for The 5th International Innovation, Design and Articulation (I-Idea) 2020, (08 Oct 2019 - 11 Jun 2020)
  • Booth Attendant for St Jude Global Initiative in Raising Awareness About Delayed Diagnosis in Children With Cns Tumours, (27 Sep 2019 - 29 Sep 2019)