PERSONAL DETAIL


Associate Prof. Dr. Kiew Lik Voon

Department of Pharmacology
Faculty of Medicine
 
  +603-79675720
  +603-79674791
  lvkiew@um.edu.my
  Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
 
ResearcherID Link
  http://www.researcherid.com/rid/B-8789-2010


BIBLIOMETRIC DATA


 Total Articles in Publication List  39
 Articles With Citation Data  38
 Sum of the Times Cited   1098
 Average Citations per Article   28.89
 h-index   10
 Co-authors   Collaboration Network
 This information is generated from http://researcherid.com

BIOGRAPHY


Lik-Voon Kiew obtained his Ph.D. degree in Biopolymer Technology and Therapeutics from the University of Malaya, Malaysia. His current research interests are in the development and in vitro/in vivo testing of anticancer nano-therapeutics and nano-drug-carriers for active and passive targeting (Enhanced-Permeability-Retention (EPR) effect-based) of anticancer drugs and photoactive compounds to the tumour. He is also involved in the development of renal-targeting nano-drug-carriers for the delivery of renal protective drugs, as well as in the in vivo evaluation of synthetic and bioactive compounds/materials for toxicity, physiology impact and disease treatment efficacy. He also assesses the acute and chronic impacts of intravenous administration of nano-drug-carriers and nanotherapeutics to the cardiovascular physiology of rats using radio-telemetry techniques.

Kiew is currently an Associate Professor and head of the Nanotherapeutics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Malaysia. He has graduated seven PhD students and two MSc students; and is currently supervising three PhD students and one MSc students. He also serves as an internal examiner for the Bachelor of Dental Surgery program and the Bachelor of Medicine/Bachelor of Surgery (MBBS / UMMP) program, University of Malaya; and represent the Faculty of Medicine to coordinate the year 2 pharmacology teaching for the Bachelor of Dental Surgery program, Faculty of Dentistry, University of Malaya.

In the research community, Kiew serves as the vice president of The Malaysia Local Chapter of Controlled Release Society (MyCRS) and international committee of The Controlled Release Society (CRS), an editor for the Journal of Health and Translational Medicine, a guest editor for the Journal of Drug Delivery and Translational Research (2018), a scholarship panellist for the Human Life Advancement Foundation, a grant proposal reviewer for the Fundamental Research Grant Scheme, Ministry of Education, Malaysia, a visiting scientist to the Principe Felipe Research Centre, Valencia, Spain (2014), and a manuscript reviewer for Theranostics, Nanomedicine NBM, the Journal of Biomedical Nanotechnology, RSC Advances, International Journal of Nanomedicine, Biomedicine & Pharmacotherapy, Journal of Materials Chemistry B and BMC Nephrology. 


ACADEMIC QUALIFICATION
(Qualification), (Institution).



PROFESSIONAL
(Organisation), (Role), (Year), (Level).


  • Malaysian Society of Pharmacology and Physiology, Member, 2009 to 2013, (National)
  • Laboratory Animal Science Association of Malaysia, Treasurer, 2015 to 2017, (National)
  • Controlled Release Society, Executive Committee Member, 2016 to 2018, (National)
  • Laboratory Animal Science Association of Malaysia, Committee Member, 2017, (National)
  • Controlled Release Society (Malaysian Local Chapter), Vice-chairman, 2018 to 2020, (National)
  • Controlled Release Society (CRS), Crs International Representative (rep. Malaysian Local Chapter), 2018 to 2019, (International)

ADMINISTRATIVE DUTIES
(Role), (Level), (Start date),(End Date).


  • Editor for The Journal of Health and Translational Medicine (JUMMEC), International, 01/05/2017 to 30/04/2019
  • Member of the Institutional Animal Care and Use Committee (IACUC), Faculty of Medicine, University Malaya , Faculty, 08/12/2016 to 30/04/2018
  • Head of Unit, Faculty, 17/11/2016 to 16/11/2018 (Head, Central Unit of Advanced Research Imaging (CENTUARI), Faculty of Medicine, University of Malaya)
  • AHLI JAWATANKUASA PEMBANGUNAN INFRASTRUKTUR FAKULTI PERUBATAN, Faculty, 01/08/2016 to 31/07/2018 (-)
  • Coordinator, pharmacology course (DIA2006) for the Bachelor of Dental Surgery program, Faculty of Dentistry, UM , Faculty, 01/09/2015 to 31/08/2019
  • Coordinator, pharmacology teaching for the Basic Medical Science course (DXGC6180), Master of Clinical Dentistry program, Faculty of Dentistry, UM, Faculty, 01/09/2015 to 31/08/2019
  • Member of the Advisory Committee for the Animal Experimental Unit, Faculty of Medicine, University Malaya , Faculty, 13/02/2012
  • Coordinator, pharmacology courses (MWEF1108, MWEF2103) for the Bachelor in Pharmacy [B. Pharm.(Hons)] program, Faculty of Medicine, UM , Faculty, 24/11/2011 to 14/02/2014
  • Assistant coordinator, pharmacology courses (MWEF1108, MWEF2103) for the Bachelor in Pharmacy [B. Pharm.(Hons)] program, Faculty of Medicine, UM, Faculty, 22/01/2009 to 23/11/2011

AREAS OF EXPERTISE
(Area).


  • Drug Delivery Systems R&D (Drug targeting, drug delivery, nanotherapeutics, nano-drug-carriers)
  • Anticancer Nanotherapeutics (Nano-drug-carrier for anticancer therapy / drug delivery, enhanced permeability-retention effect (EPR), polymer-drug-conjugate, poly-L-glutamic acid, graphene oxide )
  • Organ-Selective Drug Delivery (Nano-drug-carriers for organ-selective drug delivery, renal drug delivery)
  • Nanotoxicology and Nanosafety (Telemetry-based assessment on the impact of nano-sized-constructs administration to cardiovascular physiology )
  • Renal Pharmacology (acute renal failure, chronic renal failire, ischaemia-reperfusion injury, diabetic nephropathy )
  • In Vivo Drug Evalaution (in vivo drug testing, rat, mice, animal tumour models, biocompatibility, toxicity, efficacy, biosidtribution, pharmacokinetics, in vivo imaging, histopathology )


RECENT SELECTED PUBLICATIONS
(Publication).


Article in Academic Journals

2018
  • Siriviriyanun, A., Tsai, Y.J., Voon, S.H., Kiew, S.F., Imae, T., Kiew, L.V., Looi, C.Y., Wong, W.F., Lee, H.B., Chung. L.Y. (2018). Cyclodextrin- and dendrimer-conjugated graphene oxide as a nanocarrier for the delivery of selected chemotherapeutic and photosensitizing agents. Materials Science & Engineering C, 89, 307-315. DOI: https://doi.org/10.1016/j.msec.2018.04.020 (IF 4.164, Tier 2) (ISI-Indexed)
  • Kue, C.S., Ng, S.Y, Voon, S.H., Kamkaew, A., Chung, L.Y., Kiew, L.V., Lee, H.B. (2018) Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: An updated review. Photochemical & Photobiological Sciences. 17, 1691-1708. DOI: 10.1039/C8PP00113H (IF: 2.34) (ISI-Indexed)
  • Chambre, L., Saw, W.S., Ekineker, G., Kiew, L.V., Chong, W.Y., Lee, H.B., Chung, L.Y., Bretonnière, Y., Dumoulin, F., Sanyal, A. (2018) A Surfactant-Free Direct Access to Porphyrin-Crosslinked Nanogels for Photodynamic and Photothermal Therapy. Bioconjugate Chemistry. (Accepted for publication on 14/11/18, DOI: 10.1021/acs.bioconjchem.8b00787) (IF: 4.49, Tier 1) (ISI-Indexed)
  • Cheah, H.Y., Gallon, E., Dumoulin, F., Hoe, S.Z., Japundžić-Žigon, N., Glumac, S., Lee, H.B., Anand, P., Chung, L.Y., Vicent, M.J., Kiew, L.V. (2018) Near-infrared activatable phthalocyanine-poly-L-glutamic acid conjugate: enhanced in vivo safety and antitumor efficacy towards an effective photodynamic cancer therapy. Molecular Pharmaceutics, 15(7), 2594–2605. DOI: 10.1021/acs.molpharmaceut.8b00132 (IF: 4.44, Tier 1) (ISI-Indexed)
  • Saw, W. S., Ujihara, M., Chong, W. Y., Voon, S. H., Imae, T., Kiew, L. V., Lee, H. B., Sim, K S., Chung, L. Y. (2018). Size-dependent effect of cystine/citric acid-capped confeito-like gold nanoparticles on cellular uptake and photothermal cancer therapy. Colloids and Surfaces B: Biointerfaces, 161, 365-374. DOI: 10.1016/j.colsurfb.2017.10.064. (IF 3.89, Tier 1) (ISI-Indexed)

2017
  • Chai, H.J., Kiew, L.V., Chin, Y., Norazit, A., Mohd, Noor. S., Lo, Y.L., Looi, C.Y., Lau, Y.S., Lim, T.M., Wong, W.F., Abdullah, N.A., Abdul Sattar, M.Z., Johns, E.J., Chik, Z., Chung, L.Y. (2017) Renal Targeting Potential of a Polymeric Drug Carrier Poly-L-Glutamic Acid (PG) in Normal and Diabetic Rats. International Journal of Nanomedicine, 2017(12): 577-591, DOI: 10.2147/IJN.S111284 (IF: 4.38, Tier 1) (ISI-Indexed)
  • Foo, Y.Y., Periasamy, V., Kiew, L.V., Gnana Kumar, G., Abd Malek, S.N. (2017) Curcuma mangga-mediated synthesis of gold nanoparticles: characterization, stability, cytotoxicity and blood compatibility studies. Nanomaterials, 7(6), 123, doi:10.3390/nano7060123 (IF: 3.55, Tier 1) (ISI-Indexed)
  • Cheah, H.Y., Kiew, L.V., Lee, H.B., Japundzic-Zigon, N., Vicent, M.J., Hoe, S.Z., Chung, L.Y. (2017). Preclinical Safety Assessments of Nano-sized-constructs on Cardiovascular System Toxicity: A Case for Telemetry. Journal of Applied Toxicology, 37(11), 1268-1285. DOI: 10.1002/jat.3437 (IF:3.16, Tier 2) (ISI-Indexed)
  • Kiew, L.V., Cheah, H.Y., Voon, S.H., Gallon, E., Movellan, J., Ng, K.H., Alpugan, S., Lee, H.B., Dumoulin, F., Vicent, M.J., Chung, L.Y. (2017) Near-infrared activatable phthalocyanine-poly-L-glutamic acid conjugate: increased cellular uptake and light-dark toxicity ratio towards an effective photodynamic cancer therapy. Nanomedicine: Nanotechnology, Biology, and Medicine, 13(4):1447-1458, DOI: 10.1016/j.nano.2017.02.002 (IF: 6.50, Tier 1) (ISI-Indexed)
  • Cheah, H.Y., Sarenac, O., Arroyo, J.J. Vasic, M., Lozic, M., Glumac, S., Hoe, See.Z., Hindmarch, C., Murphy, D., Kiew, L.V., Lee, H.B., Vicent, M.J., Chung, L.Y., Japundzic-Zigon, N. (2017) Hemodynamic effects of HPMA copolymer based doxorubicin conjugate: a randomized controlled and comparative spectral study in conscious rats. Nanotoxicology. 11(2), 210-222. DOI: http://dx.doi.org/10.1080/17435390.2017.1285071 (IF: 7.91, Tier 1) (ISI-Indexed)
  • Kiew, S. F., Ho, Y. T., Kiew, L. V., Kah, J. C. Y., Lee, H. B., Imae, T., Chung, L. Y. (2017). Preparation and characterization of an amylase-triggered dextrin-linked graphene oxide anticancer drug nanocarrier and its vascular permeability. International Journal of Pharmaceutics, 534(1-2), 297-307, doi: 10.1016/j.ijpharm.2017.10.045 (IF: 3.65, Tier 1) (ISI-Indexed)
  • Hsu, Y.H., Hsieh, H.L., Viswanathan, G., Voon, S.H., Kue, C.S., Saw, W.S., Yeong, C.H., Che Ahmad, A., Imae, T., Kiew, L.V. Lee, H.B., Chung. L.Y. (2017). Multifunctional carbon-coated magnetic sensing graphene oxide-cyclodextrin nanohybrid for potential cancer theranosis. Journal of Nanoparticle Research. 19: 359. doi: 10.1007/s11051-017-4054-9 (IF:2.02, Tier 2). (ISI-Indexed)
  • Voon, S.H., Kue, C.S., Imae, T. Saw, W.S., Lee, H.B., Kiew, L.V., Chung, L.Y., Yusa, S. (2017). Doxorubicin-loaded micelles of amphiphilic diblock copolymer with pendant dendron improve antitumor efficacy: In vitro and in vivo studies. International Journal of Pharmaceutics. 534, 136-143, doi: 10.1016/j.ijpharm.2017.10.023 (IF: 3.65, Tier 1) (ISI-Indexed)

2016
  • Phang, W.M., Tan, A.A., Gopinath, S.C.B., Hashim, O.H., Kiew, L.V., Chen, Y. (2016) Secretion of N- and O-linked Glycoproteins from 4T1 Murine Mammary Carcinoma Cells. International Journal of Medical Sciences. 13(5):330-339. (ISI-Indexed)
  • Naeem, S., Kiew, L.V., Chung, L.Y., Ashraf, M.A., Misran, M. (2016) Liposomes as Amphiphilic Carriers: Encapsulation and Stability Aspects. Sains Malaysiana 45(1): 71-77. (ISI-Indexed)
  • Viswanathan, G., Hsu, Y.H., Voon, S.H., Imae, T., Siriviriyanun, A., Lee, H.B., Kiew, L.V., Chung, L.Y., Yusa, S. (2016) A Comparative Study of Cellular Uptake and Subcellular Localization of Doxorubicin Loaded in Self-Assemblies of Amphiphilic Copolymers with Pendant Dendron by MDAMB-231 Human Breast Cancer Cells. Macromolecular Bioscience. 16(6):882-895 (IF:3.85, Tier 1) (ISI-Indexed)
  • Naeem, S., Kiew, L.V., Chung, L.Y., Eh Suk, V.R., Mahmood, A., Misran, M.. (2016) Optimization of Phospholipid Nanoparticle Formulations Using Response Surface Methodology. Journal of Surfactants and Detergents. 19(1): 67-74. (ISI-Indexed)
  • Kue, C.S., Kamkaew, A., Burgess, K., Kiew, L.V., Chung, L.Y., Lee, H.B. (2016) Small Molecules for Active Targeting in Cancer. Medicinal Research Reviews. 36(3), 494 575 (IF: 8.43, Tier 1) (ISI-Indexed)
  • Kue, C.S., Kamkaew, A., Voon, S.H., Kiew, L.V. , Lee, H.B., Chung, L.Y., Burgess, K. TrkC Receptor Targeted Delivery of Peptidomimetic Ligand-Photodynamic Therapy (PDT) Conjugates Induces Antitumor Immune Responses. Nature Scientific Reports, 6: 37209. doi: 10.1038/srep37209 (IF: 5.23, Tier 1) (ISI-Indexed)
  • Kiew, S.F., Kiew, L.V., Lee, H.B., Imae, T., Chung, L.Y. (2016) Assessing Biocompatibility of Graphene Oxide-Based Nanocarriers: A Review. Journal of Controlled Release. 226: 217-228 (IF: 7.71, Tier 1) (ISI-Indexed)
  • Voon, S.H., Tiew, S.X., Kue, C.S., Lee,H.B., Kiew, L.V., Misran, M., Kamkaew, A., Burgess, K., Chung, L.Y. (2016) Chitosan-coated poly(lactic-co-glycolic acid)- diiodinated boron-dipyrromethene nanoparticles improve tumor selectivity and stealth properties in photodynamic cancer therapy. Journal of Biomedical Nanotechnology. 12(7):1431-1452 (IF: 5.34, Tier 1) (ISI-Indexed)

2015
  • Naeem, S., Kiew, L.V., Chung, L.Y., Teo, Y.Y., Misran, M. (2015) Drug Delivery and Innovative Pharmaceutical Development in Mimicking Red Blood Cell Membrane. Reviews in Chemical Engineering. 31(5), 491- 508. DOI: 10.1515/revce-2015-0010 (ISI-Indexed)
  • Kue, C.S., Kamkaew, A., Lee, H.B. Chung, L.Y., Kiew, L.V., Burgess, K. (2015) Targeted PDT Agent Eradicates TrkC Expressing Tumors via Photodynamic Therapy (PDT). Molecular Pharmaceutics, 12(1), 212-222 (IF: 4.57, Tier 1) (ISI-Indexed)
  • Tan, A.A., Phang, W.M., Gopinath, S.C.B., Hashim, O.H., Kiew, L.V., Chen, Y. (2015) Revealing Glycoproteins in the Secretome of MCF-7 Human Breast Cancer Cells. BioMed Research International, 2015, Article ID 453289. Published online , DOI: 10.1155/2015/453289. (ISI-Indexed)
  • Siriviriyanun, A., Popova, M., Imae, T., Kiew, L.V., Looi, C.Y., Wong, W.F., Lee, H.B., Chung, L.Y. (2015) Preparation of graphene oxide/dendrimer hybrid carriers for delivery of doxorubicin. Chemical Engineering Journal, 281, 771-781 (IF: 4.32, Tier 1) (ISI-Indexed)
  • Naeem, S., Kiew, L.V., Chung L.Y., Kiew, S.F., Misran, M. (2015) A comparative approach for preparation and physicochemical characterization of lecithin liposomes using chloroform and non- halogenated solvents. Journal of Surfactants and Detergents. Published online. DOI: 10.1007/s11743- 015-1689-3 (ISI-Indexed)
  • Ramasamy, S., Chin, S.P., Sukumaran, S.D., Buckle, M.J.C, Kiew, L.V., Chung, L.Y. (2015) In Silico and In Vitro Analysis of Bacoside A Aglycones and its Derivatives as the Constituents Responsible for the Cognitive Effects of Bacopa monnieri. PLoS ONE. 05/2015, 10(5):e0126565. DOI: 10.1371/journal.pone.0126565 (IF:3.23, Tier 1) (ISI-Indexed)

2014
  • Ramasamy, S., Kiew, L.V., Chung, L.Y. (2014) Inhibition of Human Cytochrome P450 Enzymes by Bacopa monnieri Standardized Extract and Constituents. Molecules, 19(2), 2588-2601 (ISI-Indexed)
  • Lim, S.H., Yam, M.L., Lam, M.L., Kamarulzaman, F., Samat, N., Kiew, L.V., Chung, L.Y., Lee, H.B. (2014) Photodynamic characterisation of amino acids conjugated 151-hydroxypurpurin-7-lactone for cancer treatment. Molecular Pharmaceutics, 11(9):3164-3173 (IF: 4.79, Tier 1) (ISI-Indexed)
  • Voon, S.H, Kiew, L.V., Lee, H.B., Lim, S.H., Noordin, M.I., Kamkaew, A., Burgess, K., Chung, L.Y. (2014) In Vivo Studies of Nanostructure-Based Photosensitizers for Photodynamic Cancer Therapy. Small, 10(24):4993-5013 (IF: 7.82, Tier 1) (ISI-Indexed)
  • Chin,Y., Lim, S.H., Zorlu, Y., Ahsen, V., Kiew, L.V., Chung, L.Y., Dumoulin, F., Lee, H.B.(2014) Improved Photodynamic Efficacy of Zn(II) Phthalocyanines via Glycerol Substitution. PLoS ONE 9(5): e97894. doi:10.1371/journal.pone.0097894 (IF:3.53, Tier 1) (ISI-Indexed)
  • Lim, S.H., Wu, L.X., Kiew, L.V., Chung, L.Y., Burgess, K., Lee, H.B. 2013. Rosamines Targeting the Cancer Oxidative Phosphorylation Pathway. PLoS ONE. 01/2014; 9(3):e82934 (IF:3.53, Tier 1) (ISI-Indexed)
  • Tan, A.A., Mu, A.K.W, Kiew, L.V., Chen, Y. (2014) Comparative secretomic and N-glycoproteomic profiling in human MCF-7 breast cancer and HMEpC normal epithelial cell lines using a gel-based strategy. Cancer Cell International. 2014; 14(1): 120 (ISI-Indexed)

2013
  • Kamkaew, A., Lim, S.H., Lee, H.B., Kiew, L.V., Chung, L.Y., Burgess, K. (2013) BODIPY Dyes in Photodynamic Therapy. Chemical Society Reviews, 2013, 42:77-88 (IF: 40.18, Tier 1) (ISI-Indexed)

2012
  • Kiew, L.V., Cheong, S.K., Ramli, E., Sidik, K., Lim, T.M., Chung, L.Y. Efficacy of a poly-L-glutamic acid-gemcitabine conjugate in tumor-bearing mice. Drug Development Research, 73(3): 120-129. (ISI-Indexed)

2011
  • Tan AA, Azman, S.N., Abdul Rani, N.R., Kua, B.C., Sasidharan, S., Kiew, L.V., Othman, N., Noordin, R. and Chen, Y. Optimal protein extraction methods from diverse sample types for protein profiling by using Two-Dimensional Electrophoresis (2DE). Tropical Biomedicine. 2011;28(3):602-9. (ISI-Indexed)

2010
  • L-V Kiew, S-K Cheong, K Sidik, L-Y Chung. 2010. Improved plasma stability and sustained release profile of gemcitabine via polypeptide conjugation, International Journal of Pharmaceutics. 391: 212-220. (IF: 3.78, Tier 1) (ISI/SCOPUS Indexed Publication)

2008
  • Law Chung Hiong, Kiew Lik Voon, Nor Azizan Abdullah, Munavvar A Sattar, Nazarina Abdul Rahman, Abdul Hye Khan, Edward James Johns. (2008) Effect of TGF- antisense oligodeoxynucleotide on renal function in chronic renal failure rats. Acta Pharmacologica Sinica, 29 (4): 451-457. (ISI-Indexed)

2004
  • Kiew, L.V., Munavvar, A.S., Law, C.H., Nor Azizan, A., Nazarina, A.R., Sidik, K. and EJ. Johns. (2004) Effect of antisense oligodeoxynucleotides for ICAM-1 on renal ischaemia reperfusion injury in the anaesthetised rat. The Journal of Physiology 557(3): 981-989. (IF:5.04, Tier 1) (ISI-Indexed)
Mass Media(Newspaper,Radio,Tv,Popular Magazine)

2018
  • Kiew, L.V., Yeong, C.H., Chung, L.Y. (2018). From Nanotechnology to Nanotherapeutics: Improving Anticancer Therapy. In Tan CH (Eds.), PULSE@UM Research Bulletin (2018) Issue 3 (pp. 26-28). Faculty of Medicine, University of Malaya 

AREAS OF RESEARCH
(Project title), (Role), (From)-(Until), (Level), (Source).


  • A Mechanistic Study To Identify The Upstream Therapeutic Target Of Tribenzyltin Carboxylates For Improving Cancer Chemotherapy, Consultant, 2019 - 2021, Fundamental Research Grant Scheme (FRGS), (National)
  • Nano-Drug-Carrier Assisted Targeted Drug Delivery For The Prevention And Attenuation Of Acute Kidney Injury: A Mechanistic Proof-Of-Concept In Vivo Study, Principal Investigator(PI), 2018 - 2020, RU Geran - Fakulti Program, (National)
  • Single Near Infrared Laser Activatable Photosensitizer-Dendrimer-Decorated Confeito-Like Gold Nanoparticles For Synergistic Photodynamic-Photothermal Cancer Theraphy: A Mechanistic Study, Consultant, 2018 - 2020, RU Geran - Fakulti Program, (National)
  • Surface Properties Evaluation Of Red Blood Cell Membrane With Drug And/ Or Drug Carrier By Using Langmuir Monolayer Analysis, Consultant, 2018 - 2020, RU Geran - Fakulti Program, (National)
  • Nano-stealthing the STAT3-blocker for improved anti-metastatic activity: mechanistic and pharmacological studies, Principal Investigator(PI), 2017 - 2020, Fundamental Research Grant Scheme (FRGS), (National)
  • Occupational Exposure Risks Of Nanomaterials To Pulmonary Health And Toxicity Screening Using Zebrafish Embroys, Consultant, 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - AET (Innovative Technology (ITRC)), (University)
  • In Vitro And In Vivo Tests On Graphene Oxide- Porous Superparamagnetic Nanoparticles As Contrast Agents In Magnetic Resonance Imaging Under Hyperthermia Conditions, Consultant, 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - AET (Innovative Technology (ITRC)), (University)
  • Telemetry (Stellar) based assessment on the effect of the administration of nano-drug-carriers to the cardiovascular system in the rats, Principal Investigator(PI), 2015 - 2018, Postgraduate Research Grant (PPP) - Research, (National)
  • In-vitro oncolytic measles virus treatment in human nasopharyngeal carcinoma with or without resistant phenotypes and its molecular insights from quantitative proteomics study, Co-Investigator, 2015 - 2017, Fundamental Research Grant Scheme (FRGS), (National)
  • Targeted delivery of cancer chemotherapy pro-drugs., Co-Investigator, 2013 - 2016, High Impact Research (HIR), (National)
  • Improved Efficacy Of Modified Zinc (Ii) Phthalocyanines As Photosensitizers For Photodynamic Therapy, Principal Investigator(PI), 2013 - 2014, Postgraduate Research Grant (PPP) - Research, (National)
  • Targeted delivery of anti-neoplastic photoactive compounds and peptides, Co-Investigator, 2011 - 2016, High Impact Research (HIR), (National)
  • A study on the mechanisms of action for thenootropic effects of the constituents and hepaticmetabolites of Bacopa Monnieri, Co-Investigator, 2010 - 2011, Geran Penyelidikan Universiti Malaya (UMRG), (National)
  • Carboxylated Polypeptides As Potential Renal Targeting Drug Carriers: Applications In The Delivery of Renal Protective Antioxidants For The Amelioration Of Diabetic Nephropathy, Principal Investigator(PI), 2009 - 2011, Geran Penyelidikan Universiti Malaya (UMRG), (National)
  • Expression Studies of Clusterin Isoforms in Human Breast Cancer, Co-Investigator, 2009 - 2011, Research University Grant, University of Science Malaysia, (National)
  • Development of novel drug delivery system: Application for renal drug targeting, Co-Investigator, 2007 - 2009, Fundamental Research Grant Scheme (FRGS), (National)

CONSULTATION PROJECT/CONSULTANCY
(Project title), (Role), (From)-(Until), (Organisation).


  • External IPT Evaluation Panel for Fundamental Research Grant Scheme (FRGS), Malaysia (for Taylor's University), 2018-2018, Ministry of Higher Education
  • PANELLIST FOR HUMAN LIFE ADVANCEMENT FOUNDATION (HLAF) SCHOLARSHIPS INTERVIEW, 2017-2017, HUMAN LIFE ADVANCEMENT FOUNDATION
  • PANELLIST FOR HUMAN LIFE ADVANCEMENT FOUNDATION (HLAF) SCHOLARSHIPS INTERVIEW, 2016-2016, Human Life Advancement Foundation
  • Prescribing Skills Training Workshop (MBBS Phase IIIB, Session 2014/2016, 08/01/2015), 2015-2015, Facuty of Medicine, University Malaya

AWARDS AND RECOGNITIONS
(Name of Award), (Awarding Institution), (Year Awarded), (Level).


  • Tiente Lee Biomedical Foundation - Excellent Scientific Paper Award 2018, for The Publication "Cheah, H.Y., Sarenac, O., Arroyo, J.J. Vasic, M., Lozic, M., Glumac, S., Hoe, See.Z., Hindmarch, C., Murphy, D., Kiew, L.V., Lee, H.B., Vicent, M.J., Chung, L.Y., Japundzic-Zigon, N. (2017) Hemodynamic Effects of Hpma Copolymer Based Doxorubicin Conjugate: a Randomized Controlled and Comparative Spectral Study in Conscious Rats. Nanotoxicology. 11(2), 210-222". *Award Recipient (Cheah, H.Y.), Co-Author of The Paper (Kiew, L.V.), Tien Te Lee Biomedical Foundation, Yungshin Pharmaceutical Industrial Co. Ltd. (Yspsah), Taiwan Roc, 2018, (International)
  • External Higher Learning Institute (Ipt) Evaluation Panel for Fundamental Research Grant Scheme (Frgs), Malaysia , Ministry of Higher Education, Malaysia, 2018, (National)
  • Panelist for Human Life Advancement Foundation (Hlaf) Scholarships , Human Life Advancement Foundation (Hlaf) Scholarships , 2017, (International)
  • Excellence Service Award, University Malaya, 2016, (University)
  • Tiente Lee Biomedical Foundation - Excellent Scientific Paper Award 2015, for The Publication "Kue, C.S*., Kamkaew, a., Lee, H.B. Chung, L.Y., Kiew, L.V.^, Burgess, K.^ (2015) Targeted Pdt Agent Eradicates Trkc Expressing Tumors Via Photodynamic Therapy (Pdt). Molecular Pharmaceutics, 12(1), 212-222". *Award Recipient (Kue, C.S.), ^Corresponding Authors of The Paper (Kiew, L.V., Burgess, K.), Tien Te Lee Biomedical Foundation, Taiwan, 2015, (International)
  • International European Research Council Starting Grants Support Scheme, Sea-Eu-Net, European Union, 2014, (International)
  • Certificate of Excellent Service, University Malaya, 2012, (University)
  • Best Poster Presentation Award, 6th Malaysian Pharmaceutical Society (Mps) Scientific Conference (2006), Crown Princess Hotel, Kuala Lumpur, Malaysia. 8th 10th September 2006, Malaysian Pharmaceutical Society (Mps), 2006, (National)
  • National Science Fellowship (Phd., 2003-2006), Ministry of Science, Technology and Innovation (Mosti) Malaysia, 2003, (National)
  • Gold Award for Best Presentation, National Science Fellowship (Nsf) Annual Workshop (2001). Hilton Hotel, Petaling Jaya, Selangor, Malaysia. 14th 15th January 2002., Ministry of Science, Technology and Innovation (Mosti) Malaysia, 2002, (National)
  • National Science Fellowship (Msc., 2000-2002), Ministry of Science, Technology and Innovation (Mosti) Malaysia, 2000, (National)

EXPERT LINKAGES
(Linkages Description), (Organisation), (Year of Involvement), (Duration), (Level).


  • Invited speaker for the "Nanoelectronic and Nanomecidine" colloquium session, National Nanotechnology Center, Ministry of Energy, Science, Technology, Environment and Climate Change, Malaysia, National Nanotechnology Center, Ministry of Energy, Science, Technology, Environment and Climate Change, Malaysia , 2018, 1, (National)
  • External Higher Learning Institute (IPT) Grant Proposal Evaluation Panel for Fundamental Research Grant Scheme (FRGS), Malaysia 2018, Ministry of Education Malaysia, 2018, 2, (National)
  • Invited speaker for Inaugural Faculty of Medicine and Health Sciences Scientific Meeting 2017, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman. Malaysia, 2017, 1, (National)
  • Invited speaker for 7th Asian Conference on Colloid and Interface Science, Asian Society for Colloid and Surface Science, 2017, 1, (International)
  • Visiting Scientist, Centro de Investigacion Principe Felipe (CIPF), Valencia, Spain, 2014, 11, (International)
  • Sabbatical Research Attachment, Polymer Therapeutics Laboratory, Centro de Investigacion Principe Felipe (CIPF), Valencia, Spain, 2014, 9, (International)

EXPERT/TECHNICAL CONTRIBUTIONS
(Activity), (Organisation), (Role), (From)-(Until), (Level).


  • External Higher Learning Institute (IPT) Grant Proposal Evaluation Panel for Fundamental Research Grant Scheme (FRGS), Malaysia 2018, Ministry of Higher Education Malaysia, Consultant, 2018-2018, (National)
  • 6th National Conference on Laboratory Animal Science, Laboratory Animal Science Association of Malaysia (LASAM), Committee Member, 2018-2018, (National)
  • 1st International Health and Medical Sciences Conference, Taylor's University, Committee Member, 2018-2019, (International)
  • 2nd LASAM Workshop on IACUC, Laboratory Animal Science Association of Malaysia (LASAM), Committee Member, 2018-2018, (National)
  • Evaluation Panel for Fundamental Research Grant Scheme (FRGS) Phase 1/2018, IPPP, University of Malaya, University of Malaya, Consultant, 2018-2018, (University)
  • HUMAN LIFE ADVANCEMENT FOUNDATION (HLAF) SCHOLARSHIPS INTERVIEW, HUMAN LIFE ADVANCEMENT FOUNDATION (HLAF), Consultant, 2017-2017, (International)
  • 7th Asian Conference on Colloid and Interface Science, Asian Society for Colloid and Surface Science, Committee Member, 2017-2017, (International)

EVALUATION ACTIVITIES
(Description), (Evaluation Activity),(Year).


  • Manuscript reviewer for Nanomedicine NBM 31/3/2018 (Impact Factor: 6.500), Article In Journal ,  (2018 - 2018)
  • Member of the Board of Examiners for Year Two Final and Supplementary Examinations, Bachelor of Dental Surgery (BDS) degree, Faculty of Dentistry, University of Malaya, Malaysia., Undergraduate Degree Examination ,  (2018 - 2019)
  • External Higher Learning Institute (IPT) Grant Proposal Evaluation Panel for Fundamental Research Grant Scheme (FRGS), Malaysia 2018, Project ,  (2018 - 2018)
  • Manuscript reviewer for for Theranostics 11/7/2018 (Impact factor: 8.537), Article In Journal ,  (2018 - 2018)
  • Internal Examiner (Pharmacology) for the Stage 1 Final and Supplementary Examinations, Bachelor of Medicine and Bachelor of Surgery (MBBS / UMMP) degree, Faculty of Medicine, University of Malaya, Malaysia., Undergraduate Degree Examination ,  (2018 - 2019)
  • Internal Examiner (Pharmacology) for the Year Two Final and Supplementary Examinations, Bachelor of Dental Surgery (BDS) degree, Faculty of Dentistry, University of Malaya, Malaysia., Undergraduate Degree Examination ,  (2018 - 2019)
  • Manuscript reviewer for Nanomedicine NBM 27/6/2018 (Impact Factor: 6.500), Article In Journal ,  (2018 - 2018)
  • Manuscript reviewer forJournal of Photochemistry and Photobiology A: Chemistry 1/11/2018 (Impact Factor: 2.9), Article In Journal ,  (2018 - 2018)
  • Manuscript reviewer for Nanomedicine NBM 4/3/2018 (Impact Factor: 6.500), Article In Journal ,  (2018 - 2018)
  • Manuscript reviewer for Nanomedicine NBM 15/7/2018 (Impact Factor: 6.500), Article In Journal ,  (2018 - 2018)
  • Manuscript reviewer for Nanomedicine NBM 16/8/2018 (Impact Factor: 6.500), Article In Journal ,  (2018 - 2018)
  • Manuscript reviewer for International Journal of Nanomedicine 10/7/2018 ((Impact Factor: 4.370), Article In Journal ,  (2018 - 2018)
  • Grant application reviewer for the Fundamental Research Grant Scheme, Ministry of Higher Education, Malaysia 2018, Project ,  (2018 - 2018)
  • Manuscript reviewer for Nanomedicine (Impact Factor: 5.005), Article In Journal ,  (2018 - 2018)
  • Grant application reviewer for the Fundamental Research Grant Scheme, Ministry of Higher Education, Malaysia 2017, Project ,  (2017 - 2017)
  • Manuscript reviewer for the Journal of Biomedical Nanotechnology, Article In Journal ,  (2017 - 2017)
  • Editor for the The Journal of Health and Translational Medicine, Article In Journal ,  (2017 - 2019)
  • Manuscript reviewer for the journal Nanomedicine NBM, Article In Journal ,  (2017 - 2017)
  • Internal Examiner (Pharmacology) for the Stage 1 Final and Supplementary Examinations, Bachelor of Medicine and Bachelor of Surgery (MBBS / UMMP) degree, Faculty of Medicine, University of Malaya, Malaysia., Undergraduate Degree Examination ,  (2017 - 2018)
  • Manuscript reviewer for The International Journal of Nanomedicine, Article In Journal ,  (2017 - 2017)
  • Internal Examiner (Pharmacology) for the Year Two Final and Supplementary Examinations, Bachelor of Dental Surgery (BDS) degree, Faculty of Dentistry, University of Malaya, Malaysia., Undergraduate Degree Examination ,  (2017 - 2018)
  • Manuscript reviewer for the journal Nanomedicine (Impact Factor: 5.005), Article In Journal ,  (2017 - 2017)
  • Guest Editor for the Journal of Drug Delivery and Translational Research (Impact factor:3.1), Article In Journal ,  (2017 - 2018)
  • Manuscript reviewer for BMC Nephrology, Article In Journal ,  (2016 - 2016)
  • Manuscript reviewer for Nanomedicine NBM , Article In Journal ,  (2016 - 2016)
  • Manuscript reviewer for the Journal of Materials Chemistry B, Article In Journal ,  (2016 - 2016)
  • Manuscript reviewer for the journal RSC Advances, Article In Journal ,  (2016 - 2016)
  • Internal Examiner (Pharmacology) for the Stage 1 Final and Supplementary Examinations, Bachelor of Medicine and Bachelor of Surgery (MBBS / UMMP) degree, Faculty of Medicine, University of Malaya, Malaysia., Undergraduate Degree Examination ,  (2016 - 2017)
  • Internal Examiner (Pharmacology) for the Year Two Final and Supplementary Examinations, Bachelor of Dental Surgery (BDS) degree, Faculty of Dentistry, University of Malaya, Malaysia., Undergraduate Degree Examination ,  (2016 - 2017)
  • Judge for the International Postgraduate Research Awards Seminar (InPRAS) 2016, Seminar/competition ,  (2016)
  • Manuscript reviewer for the journal RSC Advances, Article In Journal ,  (2016)
  • Manuscript reviewer for Journal of Biomedical Nanotechnology (IF: 5.34), Article In Journal ,  (2015 - 2015)
  • Manuscript reviewer for BMC Nephrology, Article In Journal ,  (2015)
  • Manuscript reviewer for BMC Complementary and Alternative Medicine, Article In Journal ,  (2015 - 2015)
  • Grant application reviewer for the University of Malaya Postgraduate Research (PPP) Grant, Project ,  (2015 - 2015)
  • Primary reviewer for animal ethics application and member of the Institutional Animal Care and Use Committee (IACUC), Faculty of Medicine, University of Malaya, Project ,  (2015 - 2015)
  • Internal Examiner (Pharmacology) for the Year Two Final and Supplementary Examinations, Bachelor of Dental Surgery (BDS) degree, Faculty of Dentistry, University of Malaya, Malaysia., Undergraduate Degree Examination ,  (2015 - 2016)
  • Evaluation of MSc Thesis "Angiotensin II and Vasopeptidase Inhibitory Activities of Gynura procumbens" Candidate: Poh Ting Fung (MGN090002), Thesis ,  (2013 - 2013)

INTELLECTUAL PROPERTY RIGHTS
(Product Name), (Type), (Reference), (Year), (Level).


  • CYCLODEXTRIN-CONJUGATED GRAPHENE OXIDE AS DRUG NANOCARRIER FOR HIGHLY EFFICIENT LOADING AND DELIVERY OF DOXORUBICIN , PATENT, UM.TNC2/UMCIC/603/993, Our ref : PIC/P/738/15/UM/CLY/993-Drug Nanocarrier , 16/11/2015, (NATIONAL)
  • A CENTRAL NERVOUS SYSTEM (CNS) DRUG FOR TREATMENT OF ALZHEIMER S DISEASE , PATENT, UM.TNC2/UMCIC/603/899, PIC/P/695/14/UM/CLY/899-Bacoside, 30/04/2015, (NATIONAL)
  • AMINO ACIDS CONJUGATED 151-HYDROXYPURPURIN-7LACTONE FOR PHOTODYNAMIC TREATMENT OF CANCER , PATENT, UM.TNC2/UMCIC/603/780, PIC/P/658/14/UM/LHB/780-AA, 03/03/2015, (NATIONAL)
  • ROSAMINES FOR TARGETING THE OXIDATIVE PHOSPHORYLATION PATHWAY, PATENT, UM.TNC2/UMCIC/603/781, PIC/P/659/14/UM/LHB/781-Rosamines, 05/02/2015, (NATIONAL)
  • SELF-ASSEMBLIES OF AMPHIPHILIC COPOLYMERS WITH PENDANT DENDRONS AS A DRUG DELIVERY SYSTEM FOR CANCER, PATENT, Your ref : UM.TNC2/UMCIC/603/1125, PIC/P/774/16/UM/CLY/1125-Copolymers , 05/10/2016, (NATIONAL)
  • GRAPHENE OXIDE-PAMAM DENDRIMER-FOLIC ACID HYBRID AS A DRUG DELIVERY SYSTEM FOR CANCER, PATENT, UM.TNC2/UMCIC/603/829, PIC/P/675/14/UM/LHB/829-Graphene, 01/09/2015, (NATIONAL)
  • GLYCEROL SUBSTITUTED ZINC (II) PHTHALOCYANINES AS PHOTODYNAMIC THERAPY AGENTS , PATENT, UM.TNC2/UMCIC/603/782, PIC/P/660/14/UM/LHB/782-Glycerol, 17/02/2014, (NATIONAL)
  • POLY-L-GLUTAMIC ACID DRUG CARRIER FOR TARGETING AND TREATING KIDNEY DISEASES , PATENT, PI2015703572 , 07/10/2015, (NATIONAL)
  • Novel Polymeric Gemcitabine Derivative For Cancer Treatment, PATENT, MyIPO, PI 2006 3917, 01/11/2006, (NATIONAL)

SUPERVISION


POST GRADUATE STUDENT
(Name of Degree), (Name of Candidates), (Title of Thesis), (Academic Session)

Completed
  • Doctoral Degree (phd), Cheah Hoay Yan, Evaluation of a near-infrared light absorbing poly-L-glutamic acid-phthalocyanine conjugate in photodynamic anticancer therapy (passed PhD viva voce examination on 13/8/18, 3 ISI Q1 + 1 Q2 papers published), 2014/2015
  • Doctoral Degree (phd), Kue Chin Siang, Evaluations on Efficacy and Immuno-Stimulatory Properties of Tropomyosin Receptor Kinase C Targeted Peptidomimetic Ligand-Diiodo-Boron Dipyrromethene Hybrids in Photodynamic Anticancer Therapy (3 ISI tier-1 papers published), 2013/2014
  • Doctoral Degree (phd), Kiew Siaw Fui, Synthesis and Characterization of a New Biocompatible Amylase-Triggered Dextrin Linked Graphene Oxide Anticancer Drug Nanocarrier and Its Vascular Permeability (3 ISI Tier-1 papers published), 2013/2014
  • Doctoral Degree (phd), Voon Siew Hui, Stealth Poly(lactic-co-glycolic Acid)-diiodinated Boron Dipyrromethene Nanoparticles to Improve Tumour Selectivity in Photodynamic Cancer Therapy (3 ISI tier-1 papers published), 2013/2014
  • Master Degree, Ng Mei Fong, Studies Of Obesity In A Mouse Model, 2011/2012
  • Master Degree, Chin Yunni, The Synthesis, Characterization, and In Vitro Evaluation of A Polypeptide Based Boron Dipyrromethene (Bodipy) Photosensitizer Drug Conjugate In Photodynamic Therapy (PDT) (1 ISI Tier-1 paper published), 2011/2012
  • Doctoral Degree (phd), Lim Siang Hui, Evaluation of BODIPY-based photodynamic therapy for cancer treatment and drug delivery (4 ISI Tier-1 papers published), 2010/2011
  • Doctoral Degree (phd), Seetha A/p Ramasamy, A study on the mechanism of action for the nootropic effects of the constituents and hepatic metabolites of Bacopa monnieri (2 ISI papers published), 2009/2010
  • Doctoral Degree (phd), Tan Aik Aun, Expression studies of clusterin isoforms in human and mouse breast cancer (4 ISI papers published), 2009/2010

Ongoing
  • Master Degree, Stephanie Sally Fong, Nano-stealthing the STAT3-blocker for improved anti-metastatic activity: mechanistic and pharmacological studies, 2017/2018
  • Doctoral Degree (phd), Saw Wen Shang, Evaluation Of Confeito-like Gold Nanoparticles Conjugated With Folate And Photosensitizer For Cancer Treatment (photothermal And Photodynamic Cancer Therapy). (1 ISI Tier-1 paper published), 2015/2016
  • Doctoral Degree (phd), Ng Shie Yin, Evaluation Of Halogenated Tetra (hydroxyphenyl) Porphyrins And TrkC Ligand-conjugated Bopidy Photosensitizers For Photodynamic Therapy (1 ISI paper published), 2014/2015
  • Doctoral Degree (phd), Sumaira Naeem, Synthetic Red Blood Cell Bilayer Membrane Liposome For Drug Delivery Applications (4 ISI papers published), 2013/2014

TEACHING
(Course Title), (Academic Session), (No of Student), (No of Contact Hours).


POST GRADUATE
  • BASIC MEDICAL SCIENCE, 2017/2018(1), 50, 1
  • BASIC MEDICAL SCIENCE, 2016/2017(1), 50, 1
  • CURRENT ISSUES TECHNOLOGIES IN BIOTECHNOLOGY, 2015/2016(2), 20, 1
FIRST DEGREE
  • PHARMACOLOGY, 2017/2018(1,2), 49, 15
  • CENTRAL NERVOUS SYSTEM & THERAPY, 2017/2018(1), 3, 7
  • DRUG ACTION AND DISCOVERY, 2017/2018(2), 30, 14
  • PHARMACOLOGY IN NURSING, 2016/2017(2), 20, 2
  • PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2016/2017(1), 18, 3
  • PHARMACOLOGY, 2016/2017(1,2), 50, 13
  • DRUG ACTION AND DISCOVERY, 2015/2016(2), 67, 8
  • CENTRAL NERVOUS SYSTEM & THERAPY, 2015/2016(1), 69, 7
  • PHARMACOLOGY AND HANDLING OF MEDICATION, 2015/2016(2), 16, 4
  • FARMAKOLOGI, 2015/2016(1,2), 56, 13
  • PRINCIPLES OF DRUG ACTION & PERIPHERAL NERVOUS SYSTEM, 2015/2016(2), 24, 8
  • FARMAKOLOGI, 2014/2015(1,2), 48, 2
  • ADVANCED MEDICAL PHARMACOLOGY, 2014/2015(2), 5, 3
  • PRINCIPLES OF DRUG ACTION & PERIPHERAL NERVOUS SYSTEM, 2014/2015(2), 68, 8
  • GENERAL PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2013/2014(1), 35, 13
  • PRINCIPLES OF GEN PHARMACOLOGY & TOXICOLOGY (B), 2013/2014(1), 1, 13
  • FARMAKOLOGI, 2013/2014(1), 69, 3
  • CENTRAL NERVOUS SYSTEM & THERAPY, 2013/2014(1), 72, 3
  • FARMAKOLOGI, 2012/2013(1,2), 60, 3
  • GENERAL PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2012/2013(1), 34, 7
  • PRINCIPLES OF DRUG ACTION & PERIPHERAL NERVOUS SYSTEM, 2012/2013(2), 81, 26
  • PRINCIPLES OF DRUG ACTION & PERIPHERAL NERVOUS SYSTEM, 2011/2012(2), 74, 8
  • PRINCIPLES OF FARMACOLOGY AND TOCSICOLOGY, 2009/2010(1), 33, 5
  • PRINCIPLES OF DRUG ACTION & PERIPHERAL NERVOUS SYSTEM, 2008/2009(2), 66, 11