Curriculum Vitae

DR. LIT LEI CHENG

Senior Lecturer
  • Department of Physiology
    Faculty of Medicine
  • 03-79674925

AREAS OF EXPERTISE


ACADEMIC QUALIFICATION


  • DIC & PhD, (Clinical Medicine Research)
    Imperial College London, Uk
  • MMedSc, (Immunology)
    Universiti Malaya (UM)
  • BSc(Hons)(Biochemistry), (Biokimia)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES


  • Ahli Jawatankuasa Program Jaminan Kualiti Fakulti Perubatan
    01 Apr 2021 - 31 Dec 2021 (Faculty)
  • Member of Faculty of Medicine Institutional Animal Care and Use Committee
    01 Jan 2021 - 31 Dec 2021 (Faculty)
  • Member of Faculty of Medicine, Institutional Animal Care and Use Committee
    01 Apr 2019 - 30 Mar 2021 (Faculty)
  • Quality Manager
    12 Nov 2018 - 11 Nov 2020 (Faculty)
  • Ahli Jawatankuasa Pengajian (JKP) for Master of Medical Sciences (Coursework & Dissertation)
    05 Oct 2017 - 04 Oct 2020 (Faculty)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Faculty)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Faculty)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Faculty)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Faculty)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Faculty)
  • Coordinator
    11 Jan 2019 - 10 Jan 2020 (Faculty)
  • Coordinator
    11 Jan 2019 - 10 Jan 2020 (Faculty)
  • Coordinator
    30 Jul 2018 - 29 Jul 2019 (Faculty)
  • Joint Unit Coordinator for Kursus Elektif Luar Fakulti (KELF) Your Body and Its Health (GIM2001)
    15 Sep 2017 - 14 Sep 2018 (Faculty)

MEMBERSHIPS


  • THE SOCIETY FOR PHYSIOLOGY, MEMBER
    Since 2018 (National)
  • THE SOCIETY FOR PHYSIOLOGY, EXECUTIVE COMMITTEE MEMBER
    2019 to 2020 (National)
  • THE SOCIETY FOR PHYSIOLOGY, EXECUTIVE COMMITTEE MEMBER
    2018 to 2019 (National)

AWARD AND STEWARDSHIP


  • Emerging Scholar Leadership Advancement Program
    University of Malaya, 2018 (University)
  • ISCOMS Research Fellowship
    International Student Congress of Medical Sciences, Groningen, The Netherlands, 2009 (International)

PUBLICATIONS


Article in Journal
WoS
  1. Cheng, Acga; Harikrishna, Jennifer Ann; Redwood, Charles S.; Lit, Lei Cheng; Nath, Swapan K.; Chua, Kek Heng (2022). Genetics Matters: Voyaging from the Past into the Future of Humanity and Sustainability, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23(7), . doi:10.3390/ijms23073976
  2. Beishenaliev, A., Faruqu, F. N., Leo, B. F., Lit, L. C., Loke, Y. L., Chang, C. C., . . . Kiew, L. V. (2021). Facile synthesis of biocompatible sub-5 nm alginate-stabilised gold nanoparticles with sonosensitising properties. Colloids and Surfaces a-Physicochemical and Engineering Aspects, 627, 10. doi: 10.1016/j.colsurfa.2021.127141
  3. Lim, S. Y., Ahmad-Annuar, A., Lohmann, K., Tan, A. H., Tay, Y. W., Lim, J. L., . . . Klein, C. (2021). Clinical phenotype of Parkinson's disease with a homozygous PRKN p.Cys441Arg mutation. Neurology Asia, 26(1), 161-166.
Others
  1. Stebbing J, Shah K, Lit LC, Gagliano T, Ditsiou A, Wang T, Wendler F, Simon T, Szabo KS, O'Hanlon T, Dean M, Roslani AC, Cheah SH, Lee SC, Giamas G. (2018) LMTK-3 confers chemo-resistance in breast cancer. Oncogene, 2018 Jun;37(23):3113-3130. doi: 10.1038/s41388-018-0197-0. [Epub ahead of print]
  2. Stebbing, J, Zhang, H, Xu, Y, Lit, L C, Green, A R, Grothey, A, Lombardo, Y, Periyasamy, M, Blighe, K, Zhang, W,Shaw, J A, Ellis, I O, Lenz, H J and Giamas, G (2015) KSR1 regulates BRCA1 degradation and inhibits breast cancer growth. Oncogene, 34 (16). pp. 2103-2114. ISSN 1476-5594
  3. Stebbing, J*, Lit, L C*, Zhang, H, Darrington, R S, Melaiu, O, Rudraraju, B and Giamas, G (2014) The regulatory roles of phosphatases in cancer. Oncogene, 33 (8). pp. 939-953. ISSN 1476-5594
  4. Xu, Yichen, Zhang, Hua, Lit, Lei C, Grothey, Arnhild, Athanasiadou, Maria, Kiritsi, Marianna, Lombardo, Ylenia, Frampton, Adam E, Green, Andrew R, Ellis, Ian O, Ali, Simak, Lenz, Heinz-Josef, Thanou, Maya, Stebbing, Justin and Giamas, Georgios (2014) The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin . Science signaling, 7 (330). ra58. ISSN 1937-9145
  5. Lit, Lei Cheng, Scott, Susan, Zhang, Hua, Stebbing, Justin, Photiou, Andrew and Giamas, Georgios (2013) LATS2 is a modulator of estrogen receptor alpha. Anticancer Research, 33 (1). pp. 53-63. ISSN 0250-7005
  6. Stebbing, J, Filipovic, A, Lit, L C, Blighe, K, Grothey, A, Xu, Y, Miki, Y, Chow, L W, Coombes, R C, Sasano, H, Shaw, J A and Giamas, G (2013) LMTK3 is implicated in endocrine resistance via multiple signaling pathways. Oncogene, 32 (28). pp. 3371-3380. ISSN 0950-9232
  7. Zhang, H, Xu, Y, Filipovic, A, Lit, L C, Koo, C-Y, Stebbing, J and Giamas, G (2013) SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1. British Journal of Cancer, 109 (10). pp. 2675-2684. ISSN 1532-1827
Article in Proceeding
  1. Xu, Y.C., Filipovic, A., Zhang, H., Lit, L.C., Lombardo, Y., Stebbing, J., Giamas, G. (2013). The role of LMTK3 in breast cancer cell growth and invasion. Cancer Research. 73 (8).
  2. L.C.Lit, S.H.Cheah, P.C.Tan and H.M.Cheng (2010). Aqueous extract of Rodgersia sambucifolia suppress on the natural killer cell activity in normal subjects and recurrent spontaneous aborters. International Immunology Meeting Abstracts, 22 (Suppl 1 Pt 1), i58-i67 doi:10.1093/intimm/dxq082
  3. Lit Lei Cheng, Cheah Swee Hung and Cheng Hwee Ming (2007). Optimisation and use of K562 cells in lactate dehydrogenase (LDH) assay for cytotoxicity testing. Malaysian Journal of Pharmaceutical Sciences, Suppl 2, p147

PAPER PRESENTED


ORAL PRESENTER
  1. Potentiation of cytotoxic activity in human peripheral blood by Strobilanthes crispus fraction extracts, 16th International Student Congress of Medical Sciences, International Student Congress of Medical Sciences (ISCOMS) (International) (02 Jun 2009 - 05 Jun 2009)
  2. Preliminary immunomodulatory activities of the aqueous extract of Strobilanthes crispus, 22nd Scientific Meeting of the Malaysian Society of Pharmacology and Physiology, Malaysian Society of Pharmacology and Physiology (MSPP) (International) (05 Apr 2008 - 06 Apr 2008)
  3. In vitro effect of Malaysian plants on natural killer cell activity, The 12th Biological Sciences Graduate Congress 2007, Biological Sciences Graduate Congress (BSGC) (International) (17 Dec 2007 - 19 Dec 2007)
POSTER PRESENTER
  1. Involvement of LMTK3 in homologous recombination repair, DNA Repair & Genome Stability in a Chromatin Environment, Institute of Molecular Biology (International) (04 Jun 2015 - 07 Jun 2015)
  2. LMTK3 rescues the breast cancer cells in response to doxorubicin, Pharmacology & Physiology, International Scientific Congress 2014, Malaysian Society of Pharmacology and Physiology (MSPP) (International) (22 Aug 2014 - 24 Aug 2014)
  3. Effect of Rodgersia Sambucifolia aqueous extract on peripheral blood mononuclear cell proliferation and natural killer cell activity in vitro, Malaysian Society of Pharmacology & Physiology Scientific Meeting 2010, Malaysian Society of Pharmacology & Physiology (MSPP) (International) (02 Jun 2010 - 03 Jun 2010)

ACADEMIC/PROFESSIONAL SERVICES


Evaluation
  1. (2020) MIC4005 Research Project in Biomedical Science (2019-2020) - oral and theses examiner, (External Examiner)
  2. (2019) Protective effect of abietic acid against oxidative stress in the kidney of type-2 diabetes mellitus rat model , (Evaluator)
  3. (2019) MIC4005 Research Project in Biomedical Science (2018-2019) - oral and theses examiner for two projects, (External Examiner)
  4. (2018) Assessor for Ph.D. project proposal entitled "The involvement of cohclear frequency selectivity and centrally-mediated attentional process during selective frequency listening" , (Assesor)
  5. (2018) Evaluator for MMedSc (CD) proposal defence entitled "Mechanisms underlying effects of estradiol on morphology on expression of proteins that are involved in fluid regulation in vas deferens in rats", (Evaluator)
  6. (2018) Evaluator for MMedSc (CD) proposal defence entitled "Effects of honey from Apis bee on skeletal muscle insulin resistance in diabetes rats", (Evaluator)

SUPERVISION


Postgraduate Student
PhD/ Doctoral
  1. (2017) Production of monoclonal antibodies against human LMTK3 and the effect of LMTK3 on colorectal cancer progression in vitro, ENG SUE PING

TEACHING


Master
  1. (2021) MOA7001 - Human Physiology 1
  2. (2021) MQA7003 - Anatomy and Physiology
  3. (2020) MOA7001 - Human Physiology I
  4. (2020) MOA7003 - Human Physiology Ii
  5. (2020) MOA7005 - Advanced Medical Physiology
  6. (2020) MQA7003 - Anatomy and Physiology
  7. (2019) MQGQ6101 - Anatomy & Physiology
Bachelor/First Degree
  1. (2020) DIA1004 - Physiology
  2. (2020) GIM2001 - Your Body and Its Health
  3. (2020) MIA1001 - University of Malaya Medical Programme
  4. (2020) MIX1002 - Human Physiology I
  5. (2020) MIX1003 - Human Physiology Ii
  6. (2020) MWEF1119 - Physiology Ii
  7. (2019) DIA1004 - Physiology
  8. (2019) MIA1001 - University of Malaya Medical Programme
  9. (2018) MIA 1001 - University of Malaya Medical Programme
  10. (2018) MIX1002 - Human Physiology I

SOCIAL RESPONSIBILITY ACTIVITIES


  • Comic Challenge 2020 (Imspq) - Design Flyer, (26 May 2020 - 31 Aug 2020)
  • Keepable Cancer Walk 2019, (22 Jun 2019 - 22 Jun 2019)
  • Organising Committee for 16th Inter-Medical School Physiology Quiz (Prof. a. Raman Challenge Trophy), (15 Aug 2018 - 16 Aug 2018)
  • Ppumcare Run 2018, (22 Jul 2018 - 22 Jul 2018)
  • Organising Committee for 15th Inter-Medical School Physiology Quiz (Prof. a. Raman Challenge Trophy), (16 Aug 2017 - 17 Aug 2017)
  • Organising Committee for 9th Inter-Medical School Physiology Quiz (Prof. a. Raman Challenge Trophy), (22 Jul 2011 - 23 Jul 2011)
  • Organising Committee for 8th Inter-Medical School Physiology Quiz (Prof. a. Raman Challenge Trophy), (25 Sep 2010 - 25 Sep 2010)
  • Malaysian Participant Youth, The Ship for Southeast Asian Youth Programme (Sseayp) 2004, (01 Sep 2004 - 13 Oct 2004)