Curriculum Vitae

DR. LIT LEI CHENG

Senior Lecturer
  • Department of Physiology
    Faculty of Medicine
  • lleicheng
  • 0379674925

ACADEMIC QUALIFICATION

  • DIC & PhD, (Clinical Medicine Research)
    Imperial College London, UK
  • MMedSc, (Immunology)
    Universiti Malaya (UM)
  • BSc(Hons)(Biochemistry), (BIOKIMIA)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • Task Force Member
    01 Jan 2023 - 31 Dec 2023 (University Malaya)
  • Task Force Member
    03 Jul 2023 - 15 Sep 2023 (Faculty)
  • Task Force Member
    01 Jul 2022 - 31 Dec 2022 (Faculty)
  • Committee Members
    01 Jul 2022 - 31 Dec 2022 (Faculty)
  • Ahli Jawatankuasa Program Jaminan Kualiti Fakulti Perubatan
    01 Apr 2021 - 31 Dec 2021 (Faculty)
  • Member of Faculty of Medicine Institutional Animal Care and Use Committee
    01 Jan 2021 - 31 Dec 2021 (Faculty)
  • Member of Faculty of Medicine, Institutional Animal Care and Use Committee
    01 Apr 2019 - 30 Mar 2021 (Faculty)
  • Quality Manager
    12 Nov 2018 - 11 Nov 2020 (Department of Physiology, Faculty of Medicine)
  • Ahli Jawatankuasa Pengajian (JKP) for Master of Medical Sciences (Coursework & Dissertation)
    05 Oct 2017 - 04 Oct 2020 (Department of Physiology, Faculty of Medicine)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Department of Physiology, Faculty of Medicine)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Department of Physiology, Faculty of Medicine)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Department of Physiology, Faculty of Medicine)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Department of Physiology, Faculty of Medicine)
  • Coordinator
    09 Sep 2019 - 30 Sep 2020 (Department of Physiology, Faculty of Medicine)
  • Coordinator
    11 Jan 2019 - 10 Jan 2020 (Department of Physiology, Faculty of Medicine)
  • Coordinator
    11 Jan 2019 - 10 Jan 2020 (Department of Physiology, Faculty of Medicine)
  • Coordinator
    30 Jul 2018 - 29 Jul 2019 (Department of Physiology, Faculty of Medicine)
  • Joint Unit Coordinator for Kursus Elektif Luar Fakulti (KELF) Your Body and Its Health (GIM2001)
    15 Sep 2017 - 14 Sep 2018 (Department of Physiology, Faculty of Medicine)

MEMBERSHIPS

  • MALAYSIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, MEMBER
    2022 to 2022 (National)
  • INTERNATIONAL PARKINSON AND MOVEMENT DISORDER SOCIETY, MEMBER
    2022 to 2022 (International)
  • INTERNATIONAL PARKINSON AND MOVEMENT DISORDER SOCIETY, MEMBER
    2021 to 2021 (International)
  • INTERNATIONAL PARKINSON AND MOVEMENT DISORDER SOCIETY, MEMBER
    2021 to 2021 (International)
  • THE EUROPEAN ASSOCIATION FOR CANCER RESEARCH, MEMBER
    2021 to 2021 (International)
  • THE SOCIETY FOR PHYSIOLOGY, COMMITTEE MEMBER
    2021 to 2021 (National)
  • INTERNATIONAL PARKINSON AND MOVEMENT DISORDER SOCIETY, ASSOCIATE MEMBER
    2020 to 2021 (International)
  • THE EUROPEAN ASSOCIATION FOR CANCER RESEARCH, ACTIVE MEMBER
    2012 to 2020 (International)
  • THE SOCIETY FOR PHYSIOLOGY, EXECUTIVE COMMITTEE MEMBER
    2018 to 2019 (National)
  • MALAYSIAN SOCIETY OF PHARMACOLOGY & PHYSIOLOGY (MSPP), ACTIVE MEMBER
    2007 to 2012 (International)

AWARD AND STEWARDSHIP

  • Certificate of Excellent Service
    2023, Universiti Malaya
  • Global Health Awards for Neurodegeneration: The Biological Pathways Driving The Future of Therapeutic Development
    2022, Keystone Symposia,  (International)
  • Emerging Scholar Leadership Advancement Program
    2018, University of Malaya,  (University)
  • Iscoms Research Fellowship
    2009, International Student Congress of Medical Sciences, Groningen, The Netherlands,  (International)

PUBLICATIONS

Article in Journal
WoS
  1. Lim, Shen-Yang; Toh, Tzi Shin; Hor, Jia Wei; Lim, Jia Lun; Lit, Lei Cheng; Ahmad-Annuar, Azlina; Tay, Yi Wen; Foo, Jia Nee; Ng, Ebonne Yulin; Muthusamy, Kalai Arasu; Mohamed Ibrahim, Norlinah; Ibrahim, Khairul Azmi; Tan, Louis Chew Seng; Zulkefli, Jannah; Khairul Anuar, Anis Nadhirah; Black, Kirsten; Lis, Pawel; Xie, Fei; Cen, Zhidong; Lim, Kai Shi; Lohmann, Katja; Padmanabhan, Shalini; Alessi, Dario R.; Luo, Wei; Tan, Eng King; Sammler, Esther; Tan, Ai Huey (2025). Clinical and functional evidence for the pathogenicity of the LRRK2 p.Arg1067Gln variant, NPJ PARKINSONS DISEASE. 11(1). doi:10.1038/s41531-025-00884-6
  2. Lim, Shen -Yang; Tan, Ai Huey; Foo, Jia Nee; Tan, Yi Jayne; Chew, Elaine G. Y.; Annuar, Azlina Ahmad; Closas, Alfand Marl Dy; Pajo, Azalea; Lim, Jia Lun; Tay, Yi Wen; Nadhirah, Anis; Hor, Jia Wei; Toh, Tzi Shin; Lit, Lei Cheng; Zulkefli, Jannah; Ngim, Su Juen; Lim, Weng Khong; Morris, Huw R.; Tan, Eng-King; Ng, Adeline S. L. (2024). Loss-of-Function Variant in the SMPD1 Gene in Progressive Supranuclear Palsy-Richardson Syndrome Patients of Chinese Ancestry, JOURNAL OF MOVEMENT DISORDERS. 17(2), 213-217. doi:10.14802/jmd.24009
  3. Lim, Shen -Yang; Closas, Alfand Marl F. Dy; Tan, Ai Huey; Lim, Jia Lun; Tan, Yi Jayne; Vijayanathan, Yuganthini; Tay, Yi Wen; Khalid, Raihanah Binti Abdul; Ng, Wai Keong; Kanesalingam, Ruban; -Martin, Pablo Martinez; Annuar, Azlina Ahmad; Lit, Lei Cheng; Foo, Jia Nee; Lim, Weng Khong; Ng, Adeline Su Lyn; Tan, Eng-King (2023). New insights from a multi-ethnic Asian progressive supranuclear palsy cohort, PARKINSONISM & RELATED DISORDERS. 108. doi:10.1016/j.parkreldis.2023.105296
  4. Tay, Yi Wen; Tan, Ai Huey; Lim, Jia Lun; Lohmann, Katja; Ibrahim, Khairul Azmi; Aziz, Zariah Abdul; Chin, Yen Theng; Mawardi, Ahmad Shahir; Lim, Thien Thien; Looi, Irene; Chia, Yuen Kang; Ooi, Joshua Chin Ern; Cheah, Wee Kooi; Closas, Alfand Marl F. Dy; Lit, Lei Cheng; Hor, Jia Wei; Toh, Tzi Shin; Muthusamy, Kalai Arasu; Bauer, Peter; Skrahin, Volha; Rolfs, Arndt; Klein, Christine; Ahmad-Annuar, Azlina; Lim, Shen-Yang (2023). Genetic study of early-onset Parkinson's disease in the Malaysian population, PARKINSONISM & RELATED DISORDERS. 111. doi:10.1016/j.parkreldis.2023.105399
  5. Cheng, Acga; Harikrishna, Jennifer Ann; Redwood, Charles S.; Lit, Lei Cheng; Nath, Swapan K.; Chua, Kek Heng (2022). Genetics Matters: Voyaging from the Past into the Future of Humanity and Sustainability, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23(7). doi:10.3390/ijms23073976
  6. Beishenaliev, A., Faruqu, F. N., Leo, B. F., Lit, L. C., Loke, Y. L., Chang, C. C., . . . Kiew, L. V. (2021). Facile synthesis of biocompatible sub-5 nm alginate-stabilised gold nanoparticles with sonosensitising properties. Colloids and Surfaces a-Physicochemical and Engineering Aspects, 627, 10. doi: 10.1016/j.colsurfa.2021.127141
  7. Lim, S. Y., Ahmad-Annuar, A., Lohmann, K., Tan, A. H., Tay, Y. W., Lim, J. L., . . . Klein, C. (2021). Clinical phenotype of Parkinson's disease with a homozygous PRKN p.Cys441Arg mutation. Neurology Asia, 26(1), 161-166.
  8. Stebbing, J.; Zhang, H.; Xu, Y.; Lit, L. C.; Green, A. R.; Grothey, A.; Lombardo, Y.; Periyasamy, M.; Blighe, K.; Zhang, W.; Shaw, J. A.; Ellis, I. O.; Lenz, H. J.; Giamas, G. (2021). KSR1 regulates BRCA1 degradation and inhibits breast cancer growth (vol 31, pg 2103, 2015), ONCOGENE. 40(19), 3473-3473. doi:10.1038/s41388-021-01759-9
Others
  1. Stebbing J, Shah K, Lit LC, Gagliano T, Ditsiou A, Wang T, Wendler F, Simon T, Szabo KS, O'Hanlon T, Dean M, Roslani AC, Cheah SH, Lee SC, Giamas G. (2018) LMTK-3 confers chemo-resistance in breast cancer. Oncogene, 2018 Jun;37(23):3113-3130. doi: 10.1038/s41388-018-0197-0. [Epub ahead of print]
  2. Stebbing, J, Zhang, H, Xu, Y, Lit, L C, Green, A R, Grothey, A, Lombardo, Y, Periyasamy, M, Blighe, K, Zhang, W,Shaw, J A, Ellis, I O, Lenz, H J and Giamas, G (2015) KSR1 regulates BRCA1 degradation and inhibits breast cancer growth. Oncogene, 34 (16). pp. 2103-2114. ISSN 1476-5594
  3. Stebbing, J*, Lit, L C*, Zhang, H, Darrington, R S, Melaiu, O, Rudraraju, B and Giamas, G (2014) The regulatory roles of phosphatases in cancer. Oncogene, 33 (8). pp. 939-953. ISSN 1476-5594
  4. Xu, Yichen, Zhang, Hua, Lit, Lei C, Grothey, Arnhild, Athanasiadou, Maria, Kiritsi, Marianna, Lombardo, Ylenia, Frampton, Adam E, Green, Andrew R, Ellis, Ian O, Ali, Simak, Lenz, Heinz-Josef, Thanou, Maya, Stebbing, Justin and Giamas, Georgios (2014) The kinase LMTK3 promotes invasion in breast cancer through GRB2-mediated induction of integrin . Science signaling, 7 (330). ra58. ISSN 1937-9145
  5. Lit, Lei Cheng, Scott, Susan, Zhang, Hua, Stebbing, Justin, Photiou, Andrew and Giamas, Georgios (2013) LATS2 is a modulator of estrogen receptor alpha. Anticancer Research, 33 (1). pp. 53-63. ISSN 0250-7005
  6. Stebbing, J, Filipovic, A, Lit, L C, Blighe, K, Grothey, A, Xu, Y, Miki, Y, Chow, L W, Coombes, R C, Sasano, H, Shaw, J A and Giamas, G (2013) LMTK3 is implicated in endocrine resistance via multiple signaling pathways. Oncogene, 32 (28). pp. 3371-3380. ISSN 0950-9232
  7. Zhang, H, Xu, Y, Filipovic, A, Lit, L C, Koo, C-Y, Stebbing, J and Giamas, G (2013) SILAC-based phosphoproteomics reveals an inhibitory role of KSR1 in p53 transcriptional activity via modulation of DBC1. British Journal of Cancer, 109 (10). pp. 2675-2684. ISSN 1532-1827
Article in Proceeding
  1. Xu, Y.C., Filipovic, A., Zhang, H., Lit, L.C., Lombardo, Y., Stebbing, J., Giamas, G. (2013). The role of LMTK3 in breast cancer cell growth and invasion. Cancer Research. 73 (8).
  2. L.C.Lit, S.H.Cheah, P.C.Tan and H.M.Cheng (2010). Aqueous extract of Rodgersia sambucifolia suppress on the natural killer cell activity in normal subjects and recurrent spontaneous aborters. International Immunology Meeting Abstracts, 22 (Suppl 1 Pt 1), i58-i67 doi:10.1093/intimm/dxq082
  3. Lit Lei Cheng, Cheah Swee Hung and Cheng Hwee Ming (2007). Optimisation and use of K562 cells in lactate dehydrogenase (LDH) assay for cytotoxicity testing. Malaysian Journal of Pharmaceutical Sciences, Suppl 2, p147

RESEARCH PROJECT

National
  1. 2024 - 2024, Partnership Grant
    Unravelling The Gut Microbiome Features Of Asian Lrrk2-parkinson?s Disease Patients Using Shotgun Metagenomics For Pathogenetic Insights Into The Gut-brain Axis And Discovery Of Novel Biomarkers ( Co-Researcher)
  2. 2019 - 2022, Fundamental Research Grant Scheme (FRGS)
    Understanding The Mechanism Of Extracellular Release Of ?-synuclein Through Leucine-rich Repeat Kinase 2 (lrrk2) Mutations And Kinase Inhibition ( Principal Investigator(PI))
  3. 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG) - AFR (Frontier Science)
    Development Of Highly Potent, Selective, And Brain-penetrant Aminopyridoxamine Leucine-rich Repeat Kinase 2 (lrrk2) Inhibitors For Parkinson S Disease Treatment ( Co-Researcher)
International
  1. 2023 - 2026, International Funding
    Interrogating Lrrk2 Signalling In Biosamples Derived From Patients With Parkinson's Disease Carrying The Asian Lrrk2 G2385r And R1628p Variants For Biomarker Discovery ( Co-Researcher)
  2. 2020 - 2025, International Funding
    Identifying Leucocyte And Urine Biomarkers In Pd Patients With Lrrk2 G2385r Variant ( Co-Researcher)
  3. 2021 - 2025, International Funding
    Identifying Leucocyte And Urine Biomarkers In Pd Patients With Lrrk2 R1628p Variant ( Co-Researcher)
University
  1. 2020 - 2023, Private Funding
    Investigating Mitochondrial Dysfunction As A Mechanism Of Fat Loss In Parkinson?s Disease ( Principal Investigator(PI))

PAPER PRESENTED

ORAL PRESENTER
  1. Potentiation of cytotoxic activity in human peripheral blood by Strobilanthes crispus fraction extracts, 16th International Student Congress of Medical Sciences, International Student Congress of Medical Sciences (ISCOMS) (International) (02 Jun 2009 - 05 Jun 2009)
  2. Preliminary immunomodulatory activities of the aqueous extract of Strobilanthes crispus, 22nd Scientific Meeting of the Malaysian Society of Pharmacology and Physiology, Malaysian Society of Pharmacology and Physiology (MSPP) (International) (05 Apr 2008 - 06 Apr 2008)
  3. In vitro effect of Malaysian plants on natural killer cell activity, The 12th Biological Sciences Graduate Congress 2007, Biological Sciences Graduate Congress (BSGC) (International) (17 Dec 2007 - 19 Dec 2007)
POSTER PRESENTER
  1. Involvement of LMTK3 in homologous recombination repair, DNA Repair & Genome Stability in a Chromatin Environment, Institute of Molecular Biology (International) (04 Jun 2015 - 07 Jun 2015)
  2. LMTK3 rescues the breast cancer cells in response to doxorubicin, Pharmacology & Physiology, International Scientific Congress 2014, Malaysian Society of Pharmacology and Physiology (MSPP) (International) (22 Aug 2014 - 24 Aug 2014)
  3. Effect of Rodgersia Sambucifolia aqueous extract on peripheral blood mononuclear cell proliferation and natural killer cell activity in vitro, Malaysian Society of Pharmacology & Physiology Scientific Meeting 2010, Malaysian Society of Pharmacology & Physiology (MSPP) (International) (02 Jun 2010 - 03 Jun 2010)

ACADEMIC/ PROF. SERVICES

Evaluation
  1. (2024) Panel Penilai Untuk Tugasan 3mt Kursus Metodologi - Sem 2, 2023/2024, University, (Reviewer)
  2. (2023) Scientist of Faculty of Medicine, Institutional Animal Care and Use Committee, University, (Reviewer)
  3. (2022) Panel Penilai Untuk Tugasan 3mt Kursus Metodologi, University, (Reviewer)
  4. (2022) Panel Penilai Untuk Proposal Defence, University, (Reviewer)
  5. (2021) Doctor of Philosophy Application, University, (Internal Evaluator)
  6. (2021) Doctor of Philosophy Application, University, (Internal Evaluator)
  7. (2021) Faculty of Medicine - Institutional Animal Care and Use Committee, University, (Reviewer)
  8. (2021) AJK Program Jaminan Kualiti Fakulti Perubatan, University, (Internal Evaluator)
  9. (2020) MIC4005 Research Project in Biomedical Science (2019-2020) - oral and theses examiner, (External Examiner)
  10. (2019) Protective effect of abietic acid against oxidative stress in the kidney of type-2 diabetes mellitus rat model , (Evaluator)
  11. (2019) MIC4005 Research Project in Biomedical Science (2018-2019) - oral and theses examiner for two projects, (External Examiner)
  12. (2018) Assessor for Ph.D. project proposal entitled "The involvement of cohclear frequency selectivity and centrally-mediated attentional process during selective frequency listening" , (Assesor)
  13. (2018) Evaluator for MMedSc (CD) proposal defence entitled "Mechanisms underlying effects of estradiol on morphology on expression of proteins that are involved in fluid regulation in vas deferens in rats", (Evaluator)
  14. (2018) Evaluator for MMedSc (CD) proposal defence entitled "Effects of honey from Apis bee on skeletal muscle insulin resistance in diabetes rats", (Evaluator)
Mentoring
  1. (2024) Academic Advisor for Ummp Stage 1 2023/2024, University, (Academic Advisor)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2017) Production of monoclonal antibodies against human LMTK3 and the effect of LMTK3 on colorectal cancer progression in vitro, ENG SUE PING

TEACHING

Master
  1. (2022) MQA7003 - Anatomy and Physiology
  2. (2021) MQA7003 - Anatomy and Physiology
  3. (2020) MOA7001 - Human Physiology 1
  4. (2020) MOA7005 - Advanced Medical Physiology
  5. (2019) MQA7003 - Anatomy and Physiology
  6. (2019) MWGN6109 - Advanced Medical Physiology
  7. (2018) MQGQ6101 - Anatomy & Physiology
  8. (2018) MWGN6107 - Human Physiology Ii
  9. (2017) MQGQ6101 - Anatomy and Physiology
  10. (2017) MWGN6108 - Human Physiologi I
Bachelor
  1. (2022) DIA1004 - Physiology
  2. (2022) NA - Ummp Stage 1
  3. (2022) NA - Ummp Stage 2
  4. (2022) MIC1009 - Human Body Systems I
  5. (2022) MIC1013 - Human Body Systems Ii
  6. (2022) MIX1002 - Human Physiology I
  7. (2022) MIX1003 - Human Physiology Ii
  8. (2022) GIM2001 - Your Body and Its Health
  9. (2021) MIA - Bachelor of Medicine, Bachelor of Surgery
  10. (2021) MIC1009 - Human Body Systems I
  11. (2021) MIX1002 - Human Physiology I
  12. (2021) MIX1003 - Human Physiology Ii
  13. (2021) DIA1004 - Physiology
  14. (2021) GIM2001 - Your Body and Its Health
  15. (2020) DIA1004 - Physiology
  16. (2020) MIA1001 - University of Malaya Medical Programme
  17. (2020) MWEF1119 - Physiology Ii
  18. (2019) DIA1004 - Physiology
  19. (2019) GIM2001 - Your Body and Its Health
  20. (2019) MIA1001 - University of Malaya Medical Programme
  21. (2018) MIA 1001 - University of Malaya Medical Programme
  22. (2018) MIX1003 - Human Physiology Ii

SOCIAL RESPONSIBILITY ACTIVITIES

  • Comic Challenge 2020 (Imspq) - Design Flyer, (26 May 2020 - 31 Aug 2020)
  • Keepable Cancer Walk 2019, (22 Jun 2019 - 22 Jun 2019)
  • Organising Committee for 16th Inter-Medical School Physiology Quiz (Prof. a. Raman Challenge Trophy), (15 Aug 2018 - 16 Aug 2018)
  • Ppumcare Run 2018, (22 Jul 2018 - 22 Jul 2018)
  • Organising Committee for 15th Inter-Medical School Physiology Quiz (Prof. a. Raman Challenge Trophy), (16 Aug 2017 - 17 Aug 2017)
  • Organising Committee for 9th Inter-Medical School Physiology Quiz (Prof. a. Raman Challenge Trophy), (22 Jul 2011 - 23 Jul 2011)
  • Organising Committee for 8th Inter-Medical School Physiology Quiz (Prof. a. Raman Challenge Trophy), (25 Sep 2010 - 25 Sep 2010)
  • Malaysian Participant Youth, The Ship for Southeast Asian Youth Programme (Sseayp) 2004, (01 Sep 2004 - 13 Oct 2004)