DR. LEONG SZE WEI

Liew, Kong Yen; Chee, Hui-Yee; Abas, Faridah; Leong, Sze Wei; Harith, Hanis Hazeera; Israf, Daud Ahmad; Sulaiman, Mohd Roslan; Tham, Chau Ling (2024). A synthetic curcumin-like diarylpentanoid analog inhibits rhinovirus infection in H1 hela cells via multiple antiviral mechanisms, DARU-JOURNAL OF PHARMACEUTICAL SCIENCES. . doi:10.1007/s40199-024-00542-x

Ramli, Amirah Hani; Swain, Puspanjali; Fahmi, Muhammad Syafiq Akmal Mohd; Abas, Faridah; Leong, Sze Wei; Tejo, Bimo Ario; Shaari, Khozirah; Ali, Amatul Hamizah; Agustar, Hani Kartini; Awang, Rusdam; Ng, Yee Ling; Lau, Yee Ling; Razali, Mohammad Aidiel Md; Mastuki, Siti Nurulhuda; Misnan, Norazlan Mohmad; Faudzi, Siti Munirah Mohd; Kim, Cheol-Hee (2024). Preliminary insight on diarylpentanoids as potential antimalarials: In silico, in vitro pLDH and in vivo zebrafish toxicity assessment, HELIYON. 10(5). doi:10.1016/j.heliyon.2024.e27462

Rullah, Kamal; Shamsudin, Nur Farisya; Koeberle, Andreas; Tham, Chau Ling; Fasihi Mohd Aluwi, Mohd Fadhlizil; Leong, Sze-Wei; Jantan, Ibrahim; Lam, Kok Wai (2024). Flavonoid diversity and roles in the lipopolysaccharide-mediated inflammatory response of monocytes and macrophages, FUTURE MEDICINAL CHEMISTRY. 16(1), 75-99. doi:10.4155/fmc-2023-0174

Sahudin, Muhammad Ameerullah; Law, Yu Xuan; Azmi, Khairun Nasriah; Leong, Sze Wei; Abdulwahab, Muhammad Kumayl Muhamad; Adzrill, Muhammad Hakim; Zakariah, Saodah Nurul Nabihah Mohd; Abd Karim, Nurul Huda (2024). Indole Schiff Base Complex: Synthesis and Optical Binding Investigation with Biogenic Amines, JOURNAL OF FLUORESCENCE. . doi:10.1007/s10895-024-03854-y

Shamsudin, Nur Farisya; Leong, Sze-Wei; Koeberle, Andreas; Suriya, Utid; Rungrotmongkol, Thanyada; Chia, Suet Lin; Taher, Muhammad; Haris, Muhammad Salahuddin; Alshwyeh, Hussah Abdullah; Alosaimi, Areej A.; Mediani, Ahmed; Ilowefah, Muna Abdulsalam; Islami, Deri; Faudzi, Siti Munirah Mohd; Aluwi, Mohd Fadhlizil Fasihi Mohd; Wai, Lam Kok; Rullah, Kamal (2024). A novel chromone-based as a potential inhibitor of ULK1 that modulates autophagy and induces apoptosis in colon cancer, FUTURE MEDICINAL CHEMISTRY. . doi:10.1080/17568919.2024.2363668

Su, Qi; Ren, Jiayan; Chen, Kun; Leong, Sze Wei; Han, Xu; Li, Na; Wu, Jianlin; Zhang, Yanmin (2024). Homoharringtonine promotes non-small-cell lung cancer cell death via modulating HIF-1 /ER /E2F1 feedforward loop, JOURNAL OF PHARMACY AND PHARMACOLOGY. . doi:10.1093/jpp/rgae110

Su, Qi; Wang, Jing-jing; Ren, Jia-yan; Wu, Qing; Chen, Kun; Tu, Kai-hui; Zhang, Yu; Leong, Sze Wei; Sarwar, Ammar; Han, Xu; Zhang, Mi; Dai, Wei-feng; Zhang, Yan-min (2024). Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF- /Smad2/3 pathway, ACTA PHARMACOLOGICA SINICA. 45(7), 1520-1529. doi:10.1038/s41401-024-01254-3

Islam, Rajibul; Hossain, Md. Selim; Mock, Phooi Yan; Leong, Sze Wei; Lam, Kok Wai (2023). Exploring the potential of chromone scaffold compounds in cancer therapy: targeting key kinase pathways, MEDICINAL CHEMISTRY RESEARCH. 32(6), 1017-1038. doi:10.1007/s00044-023-03063-5

Leong, Sze Wei; Wang, JingJing; Okuda, Kazuhide Shaun; Su, Qi; Zhang, Yanmin; Abas, Faridah; Chia, Suet Lin; Yusoff, Khatijah (2023). Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 254. doi:10.1016/j.ejmech.2023.115335

Liew, Kong Yen; Chee, Hui-Yee; Abas, Faridah; Leong, Sze Wei; Harith, Hanis Hazeera; Israf, Daud Ahmad; Tham, Chau Ling (2023). Curcumin-like diarylpentanoid analogues inhibit influenza A virus (H1N1) replication and pro-inflammatory cytokines production in A549 lung epithelial cells, RESPIROLOGY. 28, 27-28

Islam R., Hossain M.S., Mock P.Y., Leong S.W., Lam K.W. (2023). Exploring the potential of chromone scaffold compounds in cancer therapy: targeting key kinase pathways, Medicinal Chemistry Research. 32(6), 1017-1038. doi:10.1007/s00044-023-03063-5

Leong S.W., Wang J., Okuda K.S., Su Q., Zhang Y., Abas F., Chia S.L., Yusoff K. (2023). Discovery of a novel dual functional phenylpyrazole-styryl hybrid that induces apoptotic and autophagic cell death in bladder cancer cells, European Journal of Medicinal Chemistry. 254. doi:10.1016/j.ejmech.2023.115335

Rullah, K., Shamsudin, N. F., Koeberle, A., Tham, C. L., Mohd Aluwi, M. F. F., Leong, S. W., Jantan, I., & Lam, K. W

Chan, L. C., Kalyanasundram, J., Leong, S. W., Masarudin, M. J., Veerakumarasivam, A., Yusoff, K., Chan, S. C., & Chia, S. L. (2021). Persistent Newcastle disease virus infection in bladder cancer cells is associated with putative pro-survival and anti-viral transcriptomic changes. BMC Cancer.

Mohd Faudzi, S. M., Leong, S. W., Auwal, F. A., Abas, F., Wai, L. K., Ahmad, S., Tham, C. L., Shaari, K., Lajis, N. H., & Yamin, B. M. (2021). In silico studies, nitric oxide, and cholinesterases inhibition activities of pyrazole and pyrazoline analogs of diarylpentanoids. Archiv Der Pharmazie.

Ong, H. M., Ahmad Azmi, A. F., Leong, S. W., Abas, F., Perimal, E. K., Farouk, A. A. O., Israf, D. A., & Sulaiman, M. R. (2021). The involvement of l-arginine-nitric oxide-cgmp-atp-sensitive k+ channel pathway in antinociception of bbhc, a novel diarylpentanoid analogue, in mice model. Molecules.

Ong, H. M., Azmi, A. F. A., Leong, S. W., Abas, F., Perimal, E. K., Farouk, A. A. O., Israf, D. A., & Sulaiman, M. R. (2021). Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice. Scientific Reports.

Ullah, A., Leong, S. W., Wang, J., Wu, Q., Ghauri, M. A., Sarwar, A., Su, Q., & Zhang, Y. (2021). Cephalomannine inhibits hypoxia-induced cellular function via the suppression of APEX1/HIF-1 interaction in lung cancer. Cell Death and Disease.

Abdullah, M. A., Lee, Y. R., Mastuki, S. N., Leong, S. W., Wan Ibrahim, W. N., Mohammad Latif, M. A., Ramli, A. N. M., Mohd Aluwi, M. F. F., Mohd Faudzi, S. M., & Kim, C. H. (2020). Development of diarylpentadienone analogues as alpha-glucosidase inhibitor: Synthesis, in vitro biological and in vivo toxicity evaluations, and molecular docking analysis. Bioorganic Chemistry.

Awin, T., Mediani, A., Mohd Faudzi, S. M., Maulidiani, Leong, S. W., Shaari, K., & Abas, F. (2020). Identification of -glucosidase inhibitory compounds from Curcuma mangga fractions. International Journal of Food Properties.

Fadilah, N. I. M., Ahmad, H., Abdul Rahman, M. B., Chia, S. L., Ng, S. F., & Leong, S. W. (2020). Synthesis and in vitro biological evaluations of novel tetrapeptide as therapeutic agent for wound treatment. Journal of Saudi Chemical Society.

Leong, Sze Wei, Chia, S. L., Abas, F., & Yusoff, K. (2020a). In-vitro and in-silico evaluations of heterocyclic-containing diarylpentanoids as Bcl-2 inhibitors against lovo colorectal cancer cells. Molecules.

Leong, Sze Wei, Chia, S. L., Abas, F., & Yusoff, K. (2020b). Synthesis and in-vitro anti-cancer evaluations of multi-methoxylated asymmetrical diarylpentanoids as intrinsic apoptosis inducer against colorectal cancer. Bioorganic and Medicinal Chemistry Letters.

Yusoh, N. A., Leong, S. W., Chia, S. L., Harun, S. N., Rahman, M. B. A., Vallis, K. A., Gill, M. R., & Ahmad, H. (2020). Metallointercalator [Ru(dppz)2(PIP)]2+ Renders BRCA Wild-Type Triple-Negative Breast Cancer Cells Hypersensitive to PARP Inhibition. ACS Chemical Biology.

Awin, T., Mediani, A., Maulidiani, Leong, S. W., Muhd Faudzi, S. M., Shaari, K., & Abas, F. (2019). Phytochemical and bioactivity alterations of Curcuma species harvested at different growth stages by NMR-based metabolomics. Journal of Food Composition and Analysis.

Foo, J. B., Ng, L. S., Lim, J. H., Tan, P. X., Lor, Y. Z., Loo, J. S. E., Low, M. L., Chan, L. C., Beh, C. Y., Leong, S. W., Saiful Yazan, L., Tor, Y. S., & How, C. W. (2019). Induction of cell cycle arrest and apoptosis by copper complex Cu(SBCM)2 towards oestrogen-receptor positive MCF-7 breast cancer cells. RSC Advances.

Hisamuddin, N., Shaik Mossadeq, W. M., Sulaiman, M. R., Abas, F., Leong, S. W., Kamarudin, N., Ong, H. M., Ahmad Azmi, A. F., Ayumi, R. R., & Talib, M. (2019). Anti-edematogenic and anti-granuloma activity of a synthetic curcuminoid analog, 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one, in mouse models of inflammation. Molecules.

Leong, Sze Wei, Awin, T., Mohd Faudzi, S. M., Maulidiani, M., Shaari, K., & Abas, F. (2019). Synthesis and biological evaluation of asymmetrical diarylpentanoids as antiinflammatory, anti- -glucosidase, and antioxidant agents. Medicinal Chemistry Research.

Liew, K. Y., Rosly, N. A. dila., Abas, F., Leong, S. W., Israf, D. A., & Tham, C. L. (2019). Effect of diarylpentanoid analogues on lipopolysaccharide-induced interleukin-6 and interleukin-8 gene expression in airway inflammation. Malaysian Journal of Medicine and Health Sciences.

Nyan, L. K., Abas, F., Maulidiani, Ahmed, M., Wei, L. S., Ismail, I. S., & Shaari, K. (2019). Chemical constituents and biological activities of south east asia marine sponges: A review. In Pertanika Journal of Science and Technology.

Song, D. S. S., Leong, S. W., Ng, K. W., Abas, F., Shaari, K., Leong, C. O., Chung, F. F. L., Mai, C. W., Hii, L. W., Tan, P. J., & Patel, V. (2019). Novel 2-Benzoyl-6-(2,3-Dimethoxybenzylidene)-Cyclohexenol Confers Selectivity toward Human MLH1 Defective Cancer Cells through Synthetic Lethality. SLAS Discovery.

Kamarudin, N., Hisamuddin, N., Ong, H. M., Ahmad Azmi, A. F., Leong, S. W., Abas, F., Sulaiman, M. R., & Shaik Mossadeq, W. M. (2018). Analgesic effect of 5-(3,4-Dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one in experimental animal models of nociception. Molecules.

Leong, Sze Wei, Abas, F., Lam, K. W., & Yusoff, K. (2018). In vitro and in silico evaluations of diarylpentanoid series as -glucosidase inhibitor. Bioorganic and Medicinal Chemistry Letters.

Leong, Sze Wei, Chia, S. L., Abas, F., & Yusoff, K. (2018). Asymmetrical meta-methoxylated diarylpentanoids: Rational design, synthesis and anti-cancer evaluation in-vitro. European Journal of Medicinal Chemistry.

Fasihi Mohd Aluwi, M. F., Rullah, K., Huan, T. H., Meng, C. K., Jie, T. S., Wei, L. S., Mansor, A. H., Yamin, B. M., & Wai, L. K. (2016). Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells. RSC Advances. https://doi.org/10.1039/c6ra12754a Lasekan, O., Gholivand, S., Ping, T. C., Abas, F., Wei, L. S., & Muniandy, M. (2017). Enzymatic esterification of dihydrocaffeic acid with hexanol in different ionic liquids. In Ionic Liquids: Electrochemistry, Uses and Challenges. Mohd Faudzi, S. M., Leong, S. W., Abas, F., Mohd Aluwi, M. F. F., Rullah, K., Lam, K. W., Ahmad, S., Tham, C. L., Shaari, K., & Lajis, N. H. (2015). Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors. MedChemComm. https://doi.org/10.1039/c4md00541d Siti Zulaikha, A. G., Mediani, A., Khoo, L. W., Lee, S. Y., Leong, S. W., & Abas, F. (2017). Effect of different drying methods and solvent ratios on biological activities of Phyllanthus acidus extracts. International Food Research Journal.

Gholivand, S., Lasekan, O., Tan, C. P., Abas, F., & Wei, L. S. (2017a). Comparative study of the antioxidant activities of some lipase-catalyzed alkyl dihydrocaffeates synthesized in ionic liquid. Food Chemistry.

Gholivand, S., Lasekan, O., Tan, C. P., Abas, F., & Wei, L. S. (2017b). Optimization of enzymatic esterification of dihydrocaffeic acid with hexanol in ionic liquid using response surface methodology. Chemistry Central Journal.

Lawal, U., Leong, S. W., Shaari, K., Ismail, I. S., Khatib, A., & Abas, F. (2017). -Glucosidase Inhibitory and Antioxidant Activities of Different Ipomoea aquatica Cultivars and LC MS/MS Profiling of the Active Cultivar. Journal of Food Biochemistry.

Mohd Aluwi, M. F. F., Rullah, K., Haque, M. A., Yamin, B. M., Ahmad, W., Amjad, M. W., Lam, K. W. (2017). Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives. Medicinal Chemistry Research. doi:10.1007/s00044-017-2025-4

Velaithan, V., Okuda, K. S., Ng, M. F., Samat, N., Leong, S. W., Faudzi, S. M. M., Abas, F., Shaari, K., Cheong, S. C., Tan, P. J., & Patel, V. (2017). Zebrafish phenotypic screen identifies novel Notch antagonists. Investigational New Drugs.

Ado, M. A., Abas, F., Leong, S. W., Shaari, K., Ismail, I. S., Ghazali, H. M., & Lajis, N. H. (2016). Chemical constituents and biological activities of Callicarpa maingayi leaves. South African Journal of Botany.

Fasihi Mohd Aluwi, M. F., Rullah, K., Huan, T. H., Meng, C. K., Jie, T. S., Wei, L. S., Mansor, A. H., Yamin, B. M., & Wai, L. K. (2016). Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells. RSC Advances.

Fasihi Mohd Aluwi, M. F., Rullah, K., Koeberle, A., Werz, O., Abdul Razak, N. S., Wei, L. S., Salim, F., Ismail, N. H., Jantan, I., & Wai, L. K. (2019). Design and synthesis of a novel mPGES-1 lead inhibitor guided by 3D-QSAR CoMFA. Journal of Molecular Structure.

Leong, Sze Wei, Abas, F., Lam, K. W., Shaari, K., & Lajis, N. H. (2016). 2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorganic and Medicinal Chemistry.

Mohd Aluwi, M. F. F., Rullah, K., Yamin, B. M., Leong, S. W., Abdul Bahari, M. N., Lim, S. J., Mohd Faudzi, S. M., Jalil, J., Abas, F., Mohd Fauzi, N., Ismail, N. H., Jantan, I., & Lam, K. W. (2016). Synthesis of unsymmetrical monocarbonyl curcumin analogues with potent inhibition on prostaglandin E2 production in LPS-induced murine and human macrophages cell lines. Bioorganic and Medicinal Chemistry Letters.

Khoo, L. W., Mediani, A., Zolkeflee, N. K. Z., Leong, S. W., Ismail, I. S., Khatib, A., Shaari, K., & Abas, F. (2015). Phytochemical diversity of Clinacanthus nutans extracts and their bioactivity correlations elucidated by NMR based metabolomics. Phytochemistry Letters.

Leong, Sze Wei, Mohd Faudzi, S. M., Abas, F., Mohd Aluwi, M. F. F., Rullah, K., Lam, K. W., Abdul Bahari, M. N., Ahmad, S., Tham, C. L., Shaari, K., & Lajis, N. H. (2015). Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives. Bioorganic and Medicinal Chemistry Letters.

Maulidiani, M., Sheikh, B. Y., Mediani, A., Wei, L. S., Ismail, I. S., Abas, F., & Lajis, N. H. (2015). Differentiation of Nigella sativa seeds from four different origins and their bioactivity correlations based on NMR-metabolomics approach. Phytochemistry Letters.

Mohd Faudzi, S. M., Leong, S. W., Abas, F., Mohd Aluwi, M. F. F., Rullah, K., Lam, K. W., Ahmad, S., Tham, C. L., Shaari, K., & Lajis, N. H. (2015). Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors. MedChemComm.

Yousefi, S., Bayat, S., Rahman, M. B. A., Ismail, I. S., Saki, E., Leong, S. W., & Abdulmalek, E. (2015). Synthesis, bioactivity evaluation, and docking study of 5-aminosalicylic acid s fatty acid derivatives. Monatshefte Fur Chemie.

Leong, Sze Wei, Mohd Faudzi, S. M., Abas, F., Mohd Aluwi, M. F. F., Rullah, K., Wai, L. K., Abdul Bahari, M. N., Ahmad, S., Tham, C. L., Shaari, K., & Lajis, N. H. (2014). Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents. Molecules.

Rullah, K., Mohd Aluwi, M. F. F., Yamin, B. M., Abdul Bahari, M. N., Wei, L. S., Ahmad, S., . . . Wai, L. K. (2014). Inhibition of prostaglandin E2 production by synthetic minor prenylated chalcones and flavonoids: Synthesis, biological activity, crystal structure, and in silico evaluation. Bioorganic & Medicinal Chemistry Letters, 24(16), 3826-3834. doi:https://doi.org/10.1016/j.bmcl.2014.06.061