Curriculum Vitae

DR. KUMUTHA MALAR A/P VELLASAMY

Senior Lecturer
  • Department of Medical Microbiology
    Faculty of Medicine

AREAS OF EXPERTISE

  • BACTERIOLOGY
    Antimicrobial Resistance
  • BACTERIOLOGY
    Host Pathogen Interaction
  • BACTERIOLOGY
    Molecular biology
  • BACTERIOLOGY
    Bacterial Pathogenesis

ACADEMIC QUALIFICATION

  • PHD(UM), (Bakterialogi)
    Universiti Malaya (UM)
  • MSC(USM), (Sains)
    Universiti Sains Malaysia (Usm)
  • BSC(UM), (Mikrobiologi)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • Coordinator
    15 Aug 2023 - 14 Aug 2024 (Department of Medical Microbiology, Faculty of Medicine)
  • Quality Manager
    03 Jan 2023 - 02 Jan 2024 (Department)
  • Pelantikan sebagai Auditor bagi Eksesais Audit Kendiri Fakulti Perubatan Bil 1/2023
    03 Jul 2023 - 15 Sep 2023 (Department of Medical Microbiology, Faculty of Medicine)
  • Quality Manager
    25 Mar 2022 - 31 Dec 2022 (Department)
  • Division Chairman
    01 Dec 2020 - 30 Nov 2022 (Department of Medical Microbiology, Faculty of Medicine)
  • Coordinator
    15 Aug 2020 - 14 Aug 2022 (Department of Medical Microbiology, Faculty of Medicine)
  • Quality Manager
    25 Mar 2021 - 24 May 2021 (Department of Medical Microbiology, Faculty of Medicine)
  • Department Internal Auditor PT01
    02 Apr 2021 - 02 Apr 2021 (Department of Medical Microbiology, Faculty of Medicine)
  • Quality and Accreditation Committee Member - Customer Feedback
    01 Jan 2020 - 31 Dec 2020 (Department of Medical Microbiology, Faculty of Medicine)
  • Quality and Accreditation Committee - Customer feedback
    01 Jan 2020 - 31 Dec 2020 (Department of Medical Microbiology, Faculty of Medicine)
  • Co-Coordinator
    06 Aug 2018 - 05 Aug 2020 (Department of Medical Microbiology, Faculty of Medicine)
  • Internal Auditor
    15 Jul 2020 - 15 Jul 2020 (Department of Medical Microbiology, Faculty of Medicine)
  • Coordinator
    10 Jan 2018 - 09 Jan 2020 (Department of Medical Microbiology, Faculty of Medicine)
  • Jawatankuasa induk Audit Pengajaran dan Pembelajaran fakulti Perubatan
    15 Oct 2018 - 14 Oct 2019 (Department of Medical Microbiology, Faculty of Medicine)
  • Committee Member
    03 Jan 2018 - 02 Jan 2019 (Department of Medical Microbiology, Faculty of Medicine)
  • Auditor
    29 Oct 2018 - 29 Oct 2018 (Department of Medical Microbiology, Faculty of Medicine)
  • Invigilator
    28 May 2018 - 28 May 2018 (University Malaya)
  • Invigilator
    06 Apr 2018 - 06 Apr 2018 (Department of Medical Microbiology, Faculty of Medicine)
  • Co-coordinator - Advanced Medical Bacteriology (MFEB4401)
    11 Jan 2017 - 31 Dec 2017 (Department of Medical Microbiology, Faculty of Medicine)
  • Committee Member - Department of Medical Microbiology Journal Club
    10 Feb 2017 - 31 Dec 2017 (Department of Medical Microbiology, Faculty of Medicine)
  • Coordinator- MMB culture collection
    12 Jan 2017 - 31 Dec 2017 (Department of Medical Microbiology, Faculty of Medicine)
  • Invigilator -Barrier Assesment Stage 1 (MBBS) OSCE - 2016/2017
    12 Jul 2017 - 12 Jul 2017 (Department of Medical Microbiology, Faculty of Medicine)
  • Invigilator - RSA 2 (MBBS) - MCQ (SBA/EMQ) -2016/2017
    03 May 2017 - 03 May 2017 (Department of Medical Microbiology, Faculty of Medicine)
  • Secretory - Hands-on Training Workshop on Metagenomics (Metagenomics: Magnifying the Microbial World)
    16 Jan 2017 - 31 Mar 2017 (Department of Medical Microbiology, Faculty of Medicine)
  • Invigilator - Ujian Semester 2.1 Tahun Kedua Ijazah Sarjana Muda Pembedahan Pergigian (2016/2017) -OBA/MEQ/SAQ and OSPE
    30 Mar 2017 - 30 Mar 2017 (Dean Office, Faculty of Dentistry)
  • Invigilator - Stage 2 (MBBS) RSA1 - MCQ (2016/2017)
    03 Jan 2017 - 03 Jan 2017 (Dean Office, Faculty of Medicine)

MEMBERSHIPS

  • LIFE MEMBER, MEMBER
    Since 2021 (National)
  • ORDINARY MEMBER, MEMBER
    2011 to 2023 (National)
  • CO-COORDINATOR, COORDINATOR
    2020 to 2022 (University)
  • ORDINARY MEMBER, MEMBER
    2020 to 2021 (National)
  • ORDINARY MEMBER , MEMBER
    2011 to 2021 (National)
  • INTERNAL AUDITOR, AUDITOR
    2020 to 2020 (University)
  • FACULTY OF DENTISTRY MEMBER, MEMBER
    2020 to 2020 (University)
  • MALAYSIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY (MSBMB), MEMBER
    2011 to 2020 (National)

AWARD AND STEWARDSHIP

  • Innovation Award
    Universiti Teknologi Mara, 2023 (International)
  • Bronze Award LITEC 2020
    University of Malaya, 2020 (University)
  • Wellcome Trust Grant for Young Investigator Award
    Wellcome Trust, 2012 (International)
  • Merck Young Scientist Award (Consolation)
    MOSTI, 2010 (National)

PUBLICATIONS

Article in Journal
WoS
  1. Azizan, Suha; Cheng, Kim Jun; Mohamed, Elsa Haniffah Mejia; Ibrahim, Kamariah; Faruqu, Farid Nazer; Vellasamy, Kumutha Malar; Khong, Tak Loon; Syafruddin, Saiful Effendi; Ibrahim, Zaridatul Aini (2024). Insights into the molecular mechanisms and signalling pathways of epithelial to mesenchymal transition (EMT) in colorectal cancer: A systematic review and bioinformatic analysis of gene expression, GENE. 896. doi:10.1016/j.gene.2023.148057
  2. Barathan, Muttiah; Vellasamy, Kumutha Malar; Mariappan, Vanitha; Venkatraman, Gopinath; Vadivelu, Jamuna (2023). Naturally Occurring Phytochemicals to Target Breast Cancer Cell Signaling, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY. . doi:10.1007/s12010-023-04734-0
  3. Barathan, Muttiah; Zulpa, Ahmad Khusairy; Vellasamy, Kumutha Malar; Ibrahim, Zaridatul Aini; Hoong, See Mee; Mariappan, Vanitha; Venkatraman, Gopinath; Vadivelu, Jamuna (2023). Hyperforin-mediated anticancer mechanisms in MDA-MB-231 cell line: insights into apoptotic mediator modulation and caspase activation, JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE. 17(1). doi:10.1080/16583655.2023.2237712
  4. Lim, Yue-Min; Vadivelu, Jamuna; Mariappan, Vanitha; Venkatraman, Gopinath; Vellasamy, Kumutha Malar (2023). Effective Therapeutic Options for Melioidosis: Antibiotics versus Phage Therapy, PATHOGENS. 12(1). doi:10.3390/pathogens12010011
  5. Maniam, Lalitha; Vellasamy, Kumutha Malar; Ong, Teng Aik; Teh, Cindy Shuan Ju; Jabar, Kartini Abdul; Mariappan, Vanitha; Narayanan, Vallikkannu; Vadivelu, Jamuna; Pallath, Vinod (2023). Genotypic characteristics of Uropathogenic Escherichia coli isolated from complicated urinary tract infection (cUTI) and asymptomatic bacteriuria-a relational analysis, PEERJ. 11. doi:10.7717/peerj.15305
  6. Zulpa, Ahmad Khusairy; Muttiah, Barathan; Vellasamy, Kumutha Malar; Mariappan, Vanitha; Vadivelu, Jamuna (2023). Dentatin triggers ROS-mediated apoptosis, G0/G1 cell cycle arrest and release of Th1-related cytokines in colorectal carcinoma cells, JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE. 17(1). doi:10.1080/16583655.2023.2194231
  7. Lee, Yee Qing; Ponnampalavanar, Sasheela Sri La Sri; Chong, Chun Wie; Karunakaran, Rina; Vellasamy, Kumutha Malar; Jabar, Kartini Abdul; Kong, Zhi Xian; Lau, Min Yi; Teh, Cindy Shuan Ju (2022). Characterisation of Non-Carbapenemase-Producing Carbapenem-Resistant Klebsiella pneumoniae Based on Their Clinical and Molecular Profile in Malaysia, ANTIBIOTICS-BASEL. 11(11). doi:10.3390/antibiotics11111670
  8. Maniam, Lalitha; Vellasamy, Kumutha Malar; Jindal, Hassan Mahmood; Narayanan, Vallikannu; Danaee, Mahmoud; Vadivelu, Jamuna; Pallath, Vinod (2022). Demonstrating the utility of Escherichia coli asymptomatic bacteriuria isolates' virulence profile towards diagnosis and management-A preliminary analysis, PLOS ONE. 17(5). doi:10.1371/journal.pone.0267296
  9. Teh, Cindy Shuan Ju; Yap, Polly Soo Xi; Zulkefli, Noorfatin Jihan; Subramaniam, Prasanna; Sit, Pik San; Kong, Zhi Xian; Chong, Chun Wie; Vellasamy, Kumutha Malar; Mariappan, Vanitha; Ponnampalavanar, Sasheela; Vadivelu, Jamuna (2022). Overview of the distribution of Burkholderia pseudomallei sequence types and the Emergence of sequence type 1342 in Malaysia, TRANSBOUNDARY AND EMERGING DISEASES. . doi:10.1111/tbed.14005
  10. Alias, R., Rizwan, M., Mahmoodian, R., Vellasamy, K. M., & Hamdi, M. (2021). Physico-chemical and antimicrobial properties of Ag/Ta2O5 nanocomposite coatings. Ceramics International, 47(17), 24139-24148. doi: 10.1016/j.ceramint.2021.05.125
  11. Barathan, M., Riazalhosseini, B., Iyadorai, T., Vellasamy, K. M., Vadivelu, J., Chang, L. Y., . . . Mohamed, R. (2021). Comparative expression of pro-inflammatory and apoptotic biosignatures in chronic HBV-infected patients with and without liver cirrhosis. Microbial Pathogenesis, 161, 9. doi: 10.1016/j.micpath.2021.105231
  12. Barathan, M., Zulpa, A. K., Vellasamy, K. M., Mariappan, V., Shivashekaregowda, N. K. H., Ibrahim, Z. A., & Vadivelu, J. (2021). Cytotoxic Activity of Isoniazid Derivative in Human Breast Cancer Cells. In Vivo, 35(5), 2675-2685. doi: 10.21873/invivo.12551
  13. Barathan, Muttiah; Zulpa, Ahmad Khusairy; Hoong, See Mee; Vellasamy, Kumutha Malar; Vadivelu, Jamuna (2021). Synergistic effect of hyperforin and paclitaxel on growth inhibition, apoptotic mediator activation in MCF-7 human breast cancer cells, JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE. 15(1), 918-927. doi:10.1080/16583655.2021.2010910
  14. Choh, L. C., Ong, G. H., Chua, E. G., Vellasamy, K. M., Mariappan, V., Khan, A. M., . . . Vadivelu, J. (2021). Absence of BapA type III effector protein affects Burkholderia pseudomallei intracellular lifecycle in human host cells. Process Biochemistry, 108, 48-59. doi: 10.1016/j.procbio.2021.05.025
  15. Mariappan, V., Vellasamy, K. M., Barathan, M., Girija, A. S. S., Shankar, E. M., & Vadivelu, J. (2021). Hijacking of the Host's Immune Surveillance Radars by Burkholderia pseudomallei. Frontiers in Immunology, 12, 13. doi: 10.3389/fimmu.2021.718719
  16. Mariappan, V., Vellasamy, K. M., Mohamad, N. A., Subramaniam, S., & Vadivelu, J. (2021). OneHealth Approaches Contribute Towards Antimicrobial Resistance: Malaysian Perspective. Frontiers in Microbiology, 12. doi: 10.3389/fmicb.2021.718774
  17. Zulkefli, Noorfatin Jihan; Teh, Cindy Shuan Ju; Mariappan, Vanitha; Ngoi, Soo Tein; Vadivelu, Jamuna; Ponnampalavanar, Sasheela; Chai, Lay Ching; Chong, Chun Wie; Yap, Ivan Kok Seng; Vellasamy, Kumutha Malar (2021). Genomic comparison and phenotypic profiling of small colony variants of Burkholderia pseudomallei, PLOS ONE. 16(12). doi:10.1371/journal.pone.0261382
  18. Zulpa, A. K., Barathan, M., Iyadorai, T., Chandramathi, S., Vellasamy, K. M., Vadivelu, J., . . . Anuar, N. A. (2021). Release of pro-inflammatory cytokines TNF-alpha, IFN-gamma and IL-6 by Burkholderia pseudomallei- stimulated peripheral blood mononucleocytes of acute myeloid leukemia patients. Tropical Biomedicine, 38(2), 180-185. doi: 10.47665/tb.38.2.055
  19. Al-Maleki, A. R., Vellasamy, K. M., Mariappan, V., Venkatraman, G., Tay, S. T., Vadivelu, J. (2020). Transcriptome analysis of Burkholderia pseudomallei SCV reveals an association with virulence, stress resistance and intracellular persistence. Genomics, 112(1), 501-512. doi: 10.1016/j.ygeno.2019.04.002
  20. Alias, R., Mahmoodian, R., Genasan, K., Vellasamy, K. M., Abd Shukor, M. H., Kamarul, T. (2020). Mechanical, antibacterial, and biocompatibility mechanism of PVD grown silver-tantalum-oxide-based nanostructured thin film on stainless steel 316L for surgical applications. Materials Science Engineering C-Materials for Biological Applications, 107, 14. doi: 10.1016/j.msec.2019.110304
  21. Ganesh, P. S., Vishnupriya, S., Vadivelu, J., Mariappan, V., Vellasamy, K. M., Shankar, E. M. (2020). Intracellular survival and innate immune evasion of Burkholderia cepacia: Improved understanding of quorum sensing-controlled virulence factors, biofilm, and inhibitors. Microbiology and Immunology, 64(2), 87-98. doi: 10.1111/1348-0421.12762
  22. Iyadorai, T., Mariappan, V., Vellasamy, K. M., Wanyiri, J. W., Roslani, A. C., Lee, G. K., . . . Vadivelu, J. (2020). Prevalence and association of pks(+) Escherichia coli with colorectal cancer in patients at the University Malaya Medical Centre, Malaysia. PloS one, 15(1), 13. doi: 10.1371/journal.pone.0228217
  23. Rafieerad, A. R., Bushroa, A. R., Nasiri-Tabrizi, B., Baradaran, S., Amiri, A., Saber-Samandari, S., . . . Vadivelu, J. (2019). Simultaneous enhanced antibacterial and osteoblast cytocompatibility performance of Ti6Al7Nb implant by nano-silver/graphene oxide decorated mixed oxide nanotube composite. Surface Coatings Technology, 360, 181-195. doi:10.1016/j.surfcoat.2018.12.119
  24. Zaidi, U. Z., Mahmoodian, R., Bushroa, A., Vellasamy, K. M. Surface modification of Ti64-Alloy with silver silicon nitride thin films. Journal of Adhesion Science and Technology, 18. doi:10.1080/01694243.2019.1646462
  25. Al-Maleki, A. R., Mariappan, V., Vellasamy, K. M., Tay, S. T., Vadivelu, J. (2015). Altered Proteome of Burkholderia pseudomallei Colony Variants Induced by Exposure to Human Lung Epithelial Cells. Plos One, 10(5), 31.
Others
  1. Alias, R., Mahmoodian, R., Genasan, K., Vellasamy, K. M., Hamdi Abd Shukor, M., Kamarul, T. (2020). Mechanical, antibacterial, and biocompatibility mechanism of PVD grown silver-tantalum-oxide-based nanostructured thin film on stainless steel 316L for surgical applications. Mater Sci Eng C Mater Biol Appl. 107:110304. doi: 10.1016/j.msec.2019.110304.
  2. Iyadorai T, Mariappan V, Vellasamy KM, Wanyiri JW, Roslani AC, Goh KL, Sears C, Vadivelu J. (2020). Prevalence and association of pks+ Escherichia coli with colorectal cancer in patients at the University Malaya Medical Centre, Malaysia. PLoS One, 15(1):e0228217. doi: 10.1371/journal.pone.0228217. eCollection 2020.
  3. Menon N, Mariappan V, Vellasamy KM, Samudi C, See JX, Ganesh PS, Saeidi A, Vadivelu J, Shankar EM. Experimental exposure of Burkholderia pseudomallei crude culture filtrate upregulates PD-1 on T lymphocytes. Access Microbiol. 2020 Feb 14;2(5):acmi000110. doi: 10.1099/acmi.0.000110. PMID: 32974575; PMCID: PMC7494189.
  4. Sankar Ganesh, P., Vishnupriya, S., Vadivelu, J., Mariappan, V., Vellasamy, K. M., Shankar, E. M. (2020). Intracellular Survival and Innate Immune Evasion of Burkholderia cepacia: Improved Understanding of Quorum Sensing Controlled Virulence Factors, Biofilm and Inhibitors. Microbiology and Immunology . https://doi.org/10.1111/1348-0421.12762
  5. Al-Maleki, A. R., Vellasamy, K. M., Mariappan, V., Venkatraman, G., Tay, S. T., Vadivelu, J. (2019). Transcriptomic analysis of Burkholderia pseudomallei SCV reveals as association with virulence, stress resistance and intracellular persistence. Genomics, https://doi.org/10.1016/j.ygeno.2019.04.002
  6. Rafieerad, A. R., Bushroa, A. R., Nasiri-Tabrizi, B., Baradaran, S., Amiri, A., Saber-Samandari, S., Khanahmadi, S., Zeimaran, E., Basirun, W. J., Kalaiselvam, K., Vellasamy, K. M., Vadivelu, J. (2019). Simultaneous enhanced antibacterial and osteoblast cytocompatibility performance of Ti6Al7Nb implant by nano-silver/graphene oxide decorated mixed oxide nanotube composite. Surface & Coatings Technology, 360, 181-195
  7. A.R. Rafieerad, A.R. Bushroa, Ahmad Amiri, K. Kalaiselvam, KM Vellasamy, J. Vadivelu. 2018. Antibacterial biocompatible arginine functionalized mono-layer graphene: No more risk of silver toxicity. Journal of Hazardous Materials. 360. 132-140.
  8. Mariappan, V., Thimma, J., Vellasamy, K.M., Shanker, E. M., Vadivelu, J. (2018). Adhesion and invasion attributes of Burkholderia pseudomallei are dependent on airway surface liquid and glucose concentrations in lung epithelial cells. Environmental Microbiology Reports 10:217-225
  9. Mariappan, V., Thavagnanam, S., Vellasamy, K. M., Teh, C. S. J., Atiya, N., Ponnampalavanar, S., Vadivelu, J. (2018). Relapse of chronic melioidosis in a paediatric cystic fibrosis patient: first case report from Malaysia. BMC Infectious Diseases 18:455
  10. Nathan, S., Chieng, S., Kingsley, P. V., Mohan, A., Podin, Y., Ooi, M. H., Mariappan, V., Vellasamy, K. M., Vadivelu, J. Daim, S., How, S. H. (2018). Melioidosis in Malaysia: Incidence,Clinical Challenges, and Advances in Understanding Pathogenesis. Trop. Med. Infect. Dis. 3, 25-43.
  11. Khosravi, Y., Gan H. M., Chia, P. J. Y., Croft, L. J., Ng, C. J., Goh, K. L., Vellasamy, K. M., Mariappan, V., Ong, K. C., Wong, K. T., Loke, M. F., Vadivelu, J. (2017). The gastric microbiome of four Malaysian gastroduodenal disease patients. Scientific Pages Gene Genome Res., 1(1), 1-9
  12. Mariappan, V., Vellasamy, K. M., Vadivelu, J. (2017). Host-Adaptation of Burkholderia pseudomallei alters metabolism and virulence: a global proteome analysis. Scientific Reports 7, 9015
  13. Vadivelu, J., Vellasamy, K. M., Thimma, J., Mariappan, V., Kang, W. T., Choh, L. C., Shankar, E. M., Wong, K. T. (2017). Survival and Intra-Nuclear Trafficking of Burkholderia pseudomallei: Strategies of Evasion from Immune Surveillance? Plos Neglected Tropical Diseases 11(1): e0005241.
  14. Kang, W. T., Vellasamy, K. M., Rajamani, L., Beuerman, R. W., Vadivelu, J. (2016). Burkholderia pseudomallei type III secreted protein BipC: role in actin modulation and translocation activities required for the bacterial intracellular lifecycle. PeerJ 4, e2532.
  15. Kang, W. T., Vellasamy, K. M., Vadivelu, J. (2016). Eukaryotic pathways targeted by the type III secretion system effector protein, BipC, involved in the intracellular lifecycle of Burkholderia pseudomallei. Scientific Reports 6, 33528.
  16. Lee, L. F., Mariappan, V., Vellasamy, K. M., Lee, V. S., & Vadivelu, J. (2016). Antimicrobial activity of Tachyplesin 1 against Burkholderia pseudomallei: an in vitro and in silico approach. PeerJ 4, e2468.
  17. Ong, G. H., Choh, L. C., Vellasamy, K. M., Mariappan, V., Chang, L. Y., Vadivelu, J. (2016). Experimental phage therapy for Burkholderia pseudomallei infection. Plos One 11(7), e0158213.
  18. Vellasamy, K. M., Mariappan, V., Shankar, E. M., Vadivelu, J. (2016). Burkholderia pseudomallei differentially regulates host innate immune response genes for intracellular survival in lung epithelial cells. Plos Neglected Tropical Diseases 10(7), e0004730.
  19. Zulkefli, N. J., Mariappan, V., Vellasamy, K. M., Chong, C. W., Thong, K. L., Ponnampalavanar, S., Vadivelu, J., Teh, C. S. J. (2016). Molecular evidence of Burkholderia pseudomallei genotypes based on geographical distribution. PeerJ 4:e1802
  20. Al-Maleki, A. R., Mariappan, V., Vellasamy, K. M., Tay, S.T., Vadivelu, J. (2015). Altered Proteome of Burkholderia pseudomallei Colony Variants Induced by Exposure to Human Lung Epithelial Cells. Plos One, 10(5): e0127398.
  21. Kang, W. T., Vellasamy, K. M., Chua, E. G., Vadivelu, J. (2015). Functional Characterizations of Effector Protein BipC, a Type III Secretion System Protein, in Burkholderia pseudomallei Pathogenesis. J Infectious Diseases, 211(5), 827-834.
  22. Al-Maleki, A. R., Mariappan, V., Vellasamy, K. M., Tay, S. T., Vadivelu, J. (2014). Enhanced intracellular survival and epithelial cell adherence abilities of Burkholderia pseudomallei morphotypes are dependent on differential expression of virulence-associated proteins during mid-logarithmic growth phase. Journal of Proteomics, 106, 205-220.
  23. Khosravi, Y., Vellasamy, K. M., Mariappan, V., Ng, S. L., Vadivelu, J. (2014). Antimicrobial susceptibility and genetic characterisation of Burkholderia pseudomallei isolated from Malaysian patients. The Scientific World Journal, Article ID 132971
  24. Choh, L. C., Ong, G. H., Vellasamy, K. M., Kalaiselvam, K., Kang, W. T., Al-Maleki, A. R., Mariappan, V., Vadivelu, J. (2013). Review: Burkholderia vaccines: are we moving forward? Frontiers in Cellular and Infection Microbioiology 3,5.
  25. Mariappan, V., Vellasamy, K. M., Hashim, O. H., Vadivelu, J. (2013). Infection of Burkholderia cepacia induces homeostatic responses in the host for their prolonged survival: The microarray perspective. Plos One, 8(10): e77418.
  26. Vellasamy, K. M., Mariappan, V. M., Hashim, O. H., Vadivelu, J. (2012). Review: Functional analysis of Burkholderia virulence factors: proteomics and microarray. Journal of Analytical Science & Technology 3(1), 72-80.
  27. Mariappan, V., Vellasamy, K. M., Hashim, O. H., Vadivelu, J. (2011). Profiling of Burkholderia cepacia proteins released into the culture supernatants at mid-logarithmic and early-stationary phases of growth. Plos One, 10: e26518.
  28. Vellasamy, K. M., Mariappan, V., Hashim, O. H., Vadivelu, J. (2011). Identification of immunoreactive secretory proteins from the stationary phase culture of Burkholderia pseudomallei. Electrophoresis, 32, 310-320.
  29. Mariappan, V., Vellasamy, K. M., Hashim, O. H., Vadivelu, J. (2010). Identification of immunogenic proteins from Burkholderia cepacia secretome using proteomic analysis. Vaccine, 28, 1318-1324.
  30. Vellasamy, K. M., Chenthamarakshan, V., Puthucheary, S. D., Vadivelu, J. (2009). Comparative analysis of extracellular enzymes and virulence exhibited by Burkholderia pseudomallei from different sources. Microbial Pathogenesis, 47, 111-117.
  31. Qvist, R., Ismail, I. S., Muniandy, S., Vellasamy, K. M., Chinna, K. (2007). Correlation of Plasma C- reactive protein levels to sialic acid and lipid concentration in the normal populations. Journal of Medical Science, 7, 1049-1053.
  32. Qvist, R., Ismail, I. S., Muniandy, S., Lee, H. F., Vellasamy, K. M., Chinna, K., Zaini, A. (2005). Sialic acid and vascular cell adhesion molecule-1 as early markers in the first degree relatives of type 2 diabetes mellitus patients. Journal of Medical Science, 5, 1-6.
  33. Chenthamarakshan, V., Kumutha, M. V., Vadivelu, J., Puthucheary, S. D. (2001). Distribution of immunoglobulin classes and IgG subclasses against a culture filtrate antigen of Burkholderia pseudomallei in melioidosis patients. J Medical Microbiology, 50(1), 55-61.
Chapter in Books
  1. Khosravi, Y., Vellasamy, K. M., Tay, S. T., Vadivelu, J. (2013). Molecular detection and characterisation of Metallo- - Lactamase (MBL) Genes and integrons of Imipenem Resistant Pseudomonas aeruginosa. In A. M ndez-Vilas (Ed.), Microbial Pathogens and Strategies for Combating them: Science, Technology and Education (Vol 1, pp. 515-521) , Formatex Research Center

RESEARCH PROJECT

National
  1. 2020 - 2024, Skim Geran Penyelidikan Trans-Displin (TRGS)
    Point-of Care Aptasensor For The Detection Of Carbapenem-resistant Organisms ( Co-Researcher)
  2. 2022 - 2024, Government Agency
    Kajian Pembangunan Kaedah Pengesanan Pantas Organisma Diubahsuai Genetik (gmo) Dan Produk Gmo Dalam Makanan Ruji ( Co-Researcher)
  3. 2019 - 2023, Fundamental Research Grant Scheme (FRGS)
    Resistance Mechanisms, Survival And Clinical Outcomes Of Non-carbapenemase Producing Carbapenem-resistant Klebsiella Pneumoniae ( Co-Researcher)
  4. 2019 - 2023, Fundamental Research Grant Scheme (FRGS)
    Deciphering Survival Strategies Of Uropathogenic Escherichia Coli (upec)in Establishing Urinary Tract Infections ( Co-Researcher)
  5. 2020 - 2023, Fundamental Research Grant Scheme (FRGS)
    Characterisation And Utilisation Of Multiple 'omics' Approaches In Understanding The Pathogenesis Of Gut And Clinical B. Pseudomallei Isolates ( Principal Investigator(PI))
  6. 2020 - 2023, Fundamental Research Grant Scheme (FRGS)
    The Essential Roles Of Metabolic Reprogramming And Epigenetic Variation In The Development Of Antimicrobial Resistance In Helicobacter Pylori ( Co-Researcher)
  7. 2019 - 2022, Others MOHE - Top 100 (IIRG)-HWB
    Identification And Characterization Of The Structural Proteins Of A Bacteriophage Highly Virulent To Burkholderia Pseudomallei And Multidrug Resistant Pseudomonas Aeruginosa ( Principal Investigator(PI))
  8. 2019 - 2022, Fundamental Research Grant Scheme (FRGS)
    Anticancer Activity Of Hyperforin Against Breast Cancer Cells: Identification Of Cell Death And Autophagy Pathways ( Co-Researcher)
  9. 2017 - 2021, UM Grant - Frontier Research Grant
    Inhibitory Receptors Pathway Blockade As A Potential Cancer Therapy ( Co-Researcher)
  10. 2017 - 2020, UM Grant - Frontier Research Grant
    T Cell Immunity And Cytokines In Clinical Melioidosis ( Co-Researcher)
  11. 2019 - 2020, RU Geran - ADEC
    Learning to Learn Microbiology: An attempt to enhance self-regulated and personalised learning among undergraduate dental students of University of Malaya ( Principal Investigator(PI))
  12. 2017 - 2018, NONE
    Clonal relationship and phenotypic relatedness of multidrug resistant Pseudomonas aeruginosa isolates from UMMC ( Principal Investigator(PI))
International
  1. 2020 - 2024, International Funding
    In Vitro Activity Of Cefiderocol Against Carbapenem-resistant Klebsiella Pneumoniae, Acinetobacter Baumanii And Pseudomonas Aeruginosa From Malaysia ( Co-Researcher)
  2. 2019 - 2021, International Funding
    Incorporating Behavioural, Epidemiological And Onehealth Approaches On Human, Animal And The Environment As Contributors Of Antibiotic Resistance In Malaysia: Setting Up A Global Network ( Co-Researcher)
University
  1. 2020 - 2023, Private Funding
    Active Surveillance, Antifungal Testing And Genetic Characterization Of Candida Auris In Universiti Malaya Medical Centre ( Co-Researcher)
  2. 2017 - 2018, Private Funding
    Clonal Relationship and Phenotypic Relatedness of Multidrug Resistant Pseudomonas Aeruginosa Isolates from UMMC ( Principal Investigator(PI))

CONSULTANCY PROJECT

  • Crl-Pfizer Workshop 2023, Pfizer Malaysia Sdn Bhd, Consultant
    25 Jul 2023 - 31 Dec 2023 (University)

PAPER PRESENTED

ORAL PRESENTER
  1. Identifying genetic variants of Burkholderia pseudomallei through central intermediary metabolism typing and multilocus sequence typing., 11th Malaysia Genetics Congress., Perdana University, (National) (12 Aug 2015 - 13 Aug 2015)
  2. Host- Adaptation of Burkholderia pseudomallei Alters the Metabolism Function : a Global Comparative Proteomic Analysis, European Melioidosis Congress 2015, European Melioidosis Congress (International) (25 Mar 2015 - 28 Mar 2015)
  3. Comparison of pathogenic characteristics of Burkholderia pseudomallei morphotypes, 7th AOHUPO CONGRESS AND 9TH INTERNATIONAL SYMPOSIUM OF THE PROTEIN SOCIETY OF THAILAND, THE PROTEIN SOCIETY OF THAILAND (International) (06 Aug 2014 - 08 Aug 2014)
  4. Proteomic analysis of Burkholderia pseudomallei colony morphology variants pre- and post- exposure to A549 at mid-logarithmic phase of growth, 1st Malaysian Proteomics Conference, Malaysian Proteomics (International) (26 Sep 2012 - 27 Sep 2012)
  5. Functional analysis of Burkholderia secretory virulence factors., University of Malaya Researchers Conference (UMRC) 2012, Universiti Malaya (University) (23 Apr 2012 - 24 Apr 2012)
  6. Functional characterisation of type III secretion system-3 effector protein BipC in Burkholderia pseudomallei pathogenesis, International Congress of the Malaysian society for Microbiology 2011, Malaysian society for Microbiology (International) (08 Dec 2011 - 11 Dec 2011)
  7. Functional Analysis of Burkholderia Secretory Virulence factors., 2011 International Symposium on Analytical Science & Technology, International Symposium on Analytical Science & Technology (International) (15 Nov 2011 - 17 Nov 2011)
  8. Identification of immunogenic proteins from Burkholderia cepacia secretome using proteomic analysis, Merck Young Scientist Award (MYSA), Merck Sdn Bhd (National) (13 Oct 2010 - 13 Oct 2010)
  9. Comparative analysis of extracellular enzymes and virulence exhibited by Burkholderia pseudomallei from different sources, Merck Young Scientist Award (MYSA), Merck Sdn Bhd (National) (13 Oct 2010 - 13 Oct 2010)
  10. Immunoproteomic analysis of Burkholderia cepacia secretory proteins at different growth phase., 14th Biological Sciences Graduate Congress, Biological Sciences Graduate Congress (International) (10 Dec 2009 - 12 Dec 2009)
  11. Comparison of immunogenic proteins by immunoproteome analysis of Burkholderia cepacia secretome, 10th APRU Doctoral Students Conference, Doctoral Students (International) (06 Oct 2009 - 10 Oct 2009)
  12. Proteome mapping of Burkholderia pseudomallei and Burkholderia cepacia secretome, ,, The MGI-Standford University 4th Progress Meeting, UKM - UM Collaborators (National) (09 Jun 2009 - 09 Jun 2009)
  13. Proteome mapping and identification of Burkholderia pseudomallei and Burkholderia cepacia secretome. Structural Genomics and Host-Pathogen Interaction Studies of Burkholderia pseudomallei, Evaluation Meeting, UKM - UM Collaborators (International) (04 Jun 2009 - 06 Jun 2009)
  14. Secretome mapping of Burkholderia pseudomallei (different sources) and Burkholderia Secretome mapping of Burkholderia pseudomallei (different sources) and Burkholderia cepacia Half Yearly Meeting and Project Evaluation for Structural Genomics of Burkholderia pseudomallei Essential Genes and Transcriptions Factors and C. elegans Genomics of Host-Pathogen Interactions,, Half Yearly Meeting and Project Evaluation for Structural Genomics of Burkholderia pseudomallei, Half Yearly Meeting (International) (06 Jun 2008 - 07 Jun 2008)
  15. Functional genomics and intracellular survival of Burkholderia pseudomallei., The MGI-Standford University 2nd Progress Meeting, UKM - UM collaborators (National) (06 Jun 2007 - 07 Jun 2007)
  16. Analysis of secreted extracellular proteins in Burkholderia cepacia using bioinformatic tools., The MGI-Standford University 1st Progress Meeting,, UKM - UM collaborators (National) (06 Jan 2007 - 07 Jan 2007)
POSTER PRESENTER
  1. Hyperforin Induces In Vitro Cell Death in MCF-7 and MDA-MB-231 cells by Inducing Inflammation, MSBMB-Taylor's Virtual Focused Meeting 2020 , Malaysian Society for Biochemistry and Molecular Biology (MSBMB) and Taylor's University faculty of Health and Medical Science (International) (19 Nov 2020 - 19 Nov 2020)
  2. B. pseudomallei Small Colony Variants: Strategy for bacterial persistence?, 2nd Anunual Microbiology and Infectious Disease Asia Congress, Microbiology and Infectious Disease Asia Congress (International) (23 Jun 2016 - 24 Jun 2015)
  3. Burkholderia pseudomallei: Antimicrobial Peptide Susceptibility and Proposed Interaction, 2nd Anunual Microbiology and Infectious Disease Asia Congress, Microbiology and Infectious Disease Asia Congress (International) (23 Jun 2015 - 24 Jun 2015)
  4. Susceptibility of planktonic and biofilm Cultures of Candida spp. Upon Exposure to Aureobasidin A and preliminary Investigation of the drug effects on Yeast Growth, INFECTIONS 2015 (Infectious disease & Microbial Genomics), Infectious disease & Microbial Genomics (International) (07 Apr 2015 - 08 Apr 2015)
  5. Transcriptional response of human lung epithelial cells to Burkholderia pseudomallei colony variants, European Melioidosis Congress 2015, European Melioidosis Congress (International) (25 Mar 2015 - 28 Mar 2015)
  6. Host-adaptation of Burkholderia pseudomallei alters metabolism and virulence factors: a global comparative proteomic analysis, Proteomic Forum, Proteomic Forum (International) (22 Mar 2015 - 25 Mar 2015)
  7. Infection of Burkholderia cepacia induces homeostatic responses in the host for their prolonged survival: the microarray perspective. 3rd International Conference on Analytical Science & Technology, 3rd International Conference on Analytical Science & Technology, Korea Basic Science Institute (International) (20 Nov 2014 - 21 Nov 2014)
  8. Protein expression profiling of Burkholderia pseudomallei colony variants, 7th world Melioidosis Congress 2013, Melioidosis Congress (International) (18 Sep 2013 - 20 Sep 2013)
  9. Comparative gene expression of colony morphology variants of Burkholderia pseudomallei pre- and post-exposure to human lung epithelial cells (A549)., 7th world Melioidosis Congress 2013, Melioidosis Congress (International) (18 Sep 2013 - 20 Sep 2013)
  10. Transcriptional response of human lung epithelial cells to Burkholderia pseudomallei live bacteria and secretory proteins, 7th world Melioidosis Congress 2013, Melioidosis Congress (International) (18 Sep 2013 - 20 Sep 2013)
  11. Differential protein expressions of Burkholderia pseudomallei environmental isolate: pre- and post-infection., 7th world Melioidosis Congress 2013, Melioidosis Congress (International) (18 Sep 2013 - 20 Sep 2013)
  12. Type III secretion system BipC protein possesses virulence determinants in Burkholderia pseudomallei pathogenesis, 17th Biological Science Graduate Congress(BSGC), Biological Science Graduate Congress (International) (08 Dec 2012 - 10 Dec 2012)
  13. Comparative proteomic analysis of colony morphology variants of Burkholderia pseudomallei pre- and post-exposure to human lung epithelial cells (A549)., 17th Biological Science Graduate Congress(BSGC), Biological Science Graduate Congress (International) (08 Dec 2012 - 10 Dec 2012)
  14. In vitro susceptibility of Burkholderia pseudomallei to antimicrobial peptides, First International Conference on Tropical Medicine and Infectious Disease: Current Trends, Challenges and Issues, Tropical Medicine and Infectious Disease (International) (04 Dec 2012 - 08 Dec 2012)
  15. Colony morphology variants of Burkholderia pseudomallei characterised by microarray analysis. First International Conference on Tropical Medicine and Infectious Diseases: Current Trends, Challenge and Issues, First International Conference on Tropical Medicine and Infectious Disease: Current Trends, Challenges and Issues, Tropical Medicine and Infectious Disease (International) (04 Dec 2012 - 08 Dec 2012)
  16. Comparative proteomic analysis of large and small colony morphology variants of Burkholderia pseudomallei, 1st Malaysian Proteomics Conference, Malaysian Proteomics (International) (26 Sep 2012 - 27 Sep 2012)
  17. Burkholderia pseudomallei host-pathogen interactions: role of live bacteria and secretory proteins., 15th International congress infectious disease (ICID)2012, infectious disease (International) (13 Jun 2012 - 16 Jun 2012)
  18. Differential host gene expression upon exposure to live Burkholderia cepacia and its secretory proteins, 15th International congress infectious disease (ICID)2012, infectious disease (International) (13 Jun 2012 - 16 Jun 2012)
  19. The Role of Live Bacteria and Secretory Proteins of Burkholderia pseudomallei in Host Pathogen Interactions, International Congress of the Malaysian society for Microbiology 2011, Malaysian society for Microbiology (International) (08 Dec 2011 - 11 Dec 2011)
  20. VIth World Melioidosis Congress 2010, Proteome profile of Burkholderia pseudomallei secretory proteins and identification of immunogenic proteins, Melioidosis Congress (International) (30 Nov 2010 - 03 Dec 2010)
  21. Differential host gene expression upon exposure to Burkholderia cepacia secretory proteins and live bacteria., VIth World Melioidosis Congress 2010, Melioidosis Congress (International) (30 Nov 2010 - 03 Dec 2010)
  22. Proteome mapping and identification of Burkholderia pseudomallei secreted proteins, 14th Biological Sciences Graduate Congress, Graduate Congress (International) (10 Dec 2009 - 12 Dec 2009)
  23. Immunoproteomics analysis of Burkholderia pseudomallei secretome, The 13th Biological Sciences Graduate Congress, Graduate Congress (International) (15 Dec 2008 - 17 Dec 2008)
  24. Comparison of immunogenic proteins by immunoproteome analysis of Burkholderia cepacia secretome, The 13th Biological Sciences Graduate Congress, Graduate Congress (International) (15 Dec 2008 - 17 Dec 2008)
  25. Hyperosmolarity condition and lung mucosal fluid pH enhances Burkholderia pseudomallei invasion to epithelial cells., 13th International Congress on Infectious Diseases (ICID), International Scientific Exchange Preliminary (International) (19 Jun 2008 - 22 Jun 2008)
  26. Invasion efficiency of Burkholderia pseudomallei from different clinical sources., 13th International Congress on Infectious Diseases (ICID), International Scientific Exchange Preliminary (International) (19 Jun 2008 - 22 Jun 2008)
  27. Identification of immunoreactive secretory antigens from Burkholderia cepacia against monoclonal antibody., 13th International Congress on Infectious Diseases (ICID), International Scientific Exchange Preliminary (International) (19 Jun 2008 - 22 Jun 2008)
  28. Comparison of exoenzymes profile of Burkholderia pseudomallei isolates from different origin, 13th International Congress on Infectious Diseases (ICID), International Scientific Exchange Preliminary (International) (19 Jun 2008 - 22 Jun 2008)
  29. Development of PCR to detect and differentiate Burkholderia genus and differentiation of the species from clinical specimen, 12th Biological Sciences Graduate Congress, Biological Sciences Graduate Congress (International) (17 Dec 2007 - 19 Dec 2007)
  30. Identification of common immunodominant secretory antigens between Burkholeria cepacia and Burkholderia pseudomallei, 5th World Melioidosis Congress, Melioidosis Congress (International) (21 Nov 2007 - 23 Nov 2007)
  31. Comparative proteome analysis of extracellular secreted protein from Burkholderia cepacia at different growth phase, 9th A-IMBN Conference & 16thMSMBB Scientific Meeting, MSMBB (International) (03 Sep 2006 - 05 Sep 2006)
  32. Comparison of secretory protein profile of Burkholderia pseudomallei and Burkholderia thailandensis using two-dimensional gel electrophoresis., 9th A-IMBN Conference & 16th MSMBB Scientific Meeting, MSMBB (National) (03 Sep 2006 - 05 Sep 2006)
PRESENTER
  1. Learning To Learn Microbiology: An Attempt To Enhance Self-Regulated And Personalised Learning Among Undergraduate Dental Students of Universiti Malaya, International Learning Improvement & Teaching Enhancement Conference (LITEC) 2020, ADeC, Universiti Malaya (University) (25 Aug 2020 - 27 Nov 2020)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2020) Reviewer for Saudi Pharmaceutical Journal (SPJ) , (Reviewer)
  2. (2020) Malaysian Applied Biology Journal, (Reviewer)
  3. (2018) Internal examiner for M.MEd.Sc. students candiature defence , (Internal Examiner)
  4. (2018) Internal examiner for M.Med.Sc. student candidature defence, (Internal Examiner)
  5. (2018) Chairperson and Internal examiner for M.Med.Sc. Proposal Defence, (Internal Examiner)
  6. (2018) Reviewer for Gut Pathogen, (Reviewer)
  7. (2018) Reviewer for Gut Pathogen, (Reviewer)
  8. (2018) Reviewer for BMC Infectious Diseases, (Reviewer)
  9. (2018) Ad-hoc committee to evaluate PhD Proposal , (Reviewer)
  10. (2018) Ad-hoc committee to review PhD Student Proposal , (Reviewer)
  11. (2018) Ad-hoc committee for masters student proposal , (Reviewer)
  12. (2018) Internal examiner for M.Med.Sc student candidature defence, (Internal Examiner)

SUPERVISION

Under Graduate Students
  1. (2018) Prevalent genotype and cyclomodulin-encoding genes in colorectal cancer colonising Escherichia coli isolates from University Malaya Medical Centre
  2. (2018) Molecular typing and phenotypic relatedness of Pseudomonas aeruginosa isolates from University Malaya Medical Centre

TEACHING

Bachelor
  1. (2020) DIA2005 - Medical Microbiology
  2. (2017) MFEB4401 - Advanced Medical Microbiology
  3. (2017) MIC2007 - Microbial Infection

SOCIAL RESPONSIBILITY ACTIVITIES

  • Sumbangan Idea dan Membantu Sjk(T) Sungai Manggis, Banting Dalam Pertandingan Inovasi dan Kreatif Sains Peringkat Kebangsaan Bagi Sekolah -Sekolah Sjk(T), (31 Mar 2017 - 13 Aug 2017)