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CURRICULUM VITAE

ASSOCIATE PROF. DR. ONG KIEN CHAI
ASSOCIATE PROF. DR. ONG KIEN CHAI
Associate Professor
Department of Biomedical Science
Faculty of Medicine
0379674799
ResearcherID
Scopus Author ID
ORCID ID

PUBLICATIONS

Article in Journal
WoS
  1. Yap, Hui Yeng Yeannie; Kong, Boon Hong; Yap, Chee Sum Alvin; Ong, Kien Chai; Zain, Rosnah Binti; Tan, Soon Hao; Zaini, Zuraiza Mohamad; Ng, Szu Ting; Tan, Chon Seng; Fung, Shin Yee (2022). Immunomodulatory Effect and an Intervention of TNF Signalling Leading to Apoptotic and Cell Cycle Arrest on ORL-204 Oral Cancer Cells by Tiger Milk Mushroom, Lignosus rhinocerus, FOOD TECHNOLOGY AND BIOTECHNOLOGY. 60(1), 80-88. doi:10.17113/ftb.60.01.22.7296
Others
  1. Hooi YT, Ong KC, Tan SH, Perera D, Wong KT. 2020. Coxsackievirus A16 in a 1-Day-Old Mouse Model of Central Nervous System Infection Shows Lower Neurovirulence than Enterovirus A71. J. Comp. Path. 176: 19-32.
  2. Hooi, Y.T., Ong, K.C., Tan, S.H., Perera D, Wong, K.T. 2020. A novel orally infected hamster model for Coxsackievirus A16 hand-foot-and-mouth disease and encephalomyelitis. Lab Invest 100, 1262 1275
  3. Nallappan, D., Ong, K. C., Palanisamy, U. D., Chua, K. H., & Kuppusamy, U. R. (2020). Myricetin derivative-rich fraction from Syzygium malaccense prevents high-fat diet-induced obesity, glucose intolerance and oxidative stress in C57BL/6J mice. Archives of physiology and biochemistry, 1-12.
  4. Yu SP, Ong KC, Tan SH, Perera D, Wong KT. 2020. Japanese encephalitis virus: Biological clones from a clinical isolate quasispecies show differing neurovirulence in vitro and in a mouse model. Neurology Asia; 25 (3): 279-284.
  5. Polymorphisms in the androgen receptor CAG repeat sequence are related to tumour stage but not to ERG or androgen receptor expression in Malaysian men with prostate cancer
  6. Tee HK, Tan CW, Yogarajah T, Lee MHP, Chai HJ, Hanapi NA, Yusof SR, Ong KC, Lee VS, Sam IC, Chan YF. 2019. Electrostatic interactions at the five-fold axis alter heparin-binding phenotype and drive enterovirus A71 virulence in mice. PLoS Pathog. 2019 Nov 15;15(11):e1007863.
  7. Yee PTI, Tan SH, Ong KC, Tan KO, Wong KT, Hassan SS, Poh CL. 2019. Development of live attenuated Enterovirus 71 vaccine strains that confer protection against lethal challenge in mice. Sci Rep. 9(1):4805.
  8. Yu SP, Ong KC, Perera D, Wong KT. 2018. Neuronal transcriptomic responses to Japanese encephalitis virus infection with a special focus on chemokine CXCL11 and pattern recognition receptors RIG-1 and MDA5. Virology, 527:107-115.
  9. NikNadia N, Tan CW, Ong KC, Sam IC, Chan YF. Identification and characterization of neutralization epitopes at VP2 and VP1 of enterovirus A71. Journal of Medical Virology 2018; 90(6): 1164-1167. doi: 10.1002/jmv.25061.
  10. Tan JSJ, Ong KC, Ong DBL, Razack A, Lim J, Yunus R, Sundram M, Rhodes A.(2018). Heterogenous expression of ERG oncoprotein in Malaysian men with adenocarcinoma of the prostate. Malays J Pathol. 40(2): 103-110.
  11. Yogarajah T, Ong KC, Perera D, Wong KT. 2018. RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5' Nontranslated Regions. J Virol. 92: E01914-17.
  12. Jindal HM, Zandi K, Ong KC, Velyuthan RV, Rasid SM, Raju CS, Sekaran SD. 2017. Mechanisms of action and in vivo antibacterial efficacy assessment of five novel hybrid peptides derived from Indilicidin and Ranalexin against Streptococcus pneumoniae. Peer J.
  13. Khosravi Y, Gan MH, Chia PJY, Croft LJ, Ng CG, Goh KL, Vellasamy KM, Mariappan V, Ong KC, Wong KT, Loke MF, Vadivelu J. 2017. The gastric microbiome of four Malaysian gastroduodenal diseases patients. Gene and Genome Research. 1: 1-9.
  14. Phyu WK, Ong KC, Wong KT. 2017. Modelling person-to-person transmission in an Enterovirus A71 orally infected hamster model of hand-foot-and-mouth disease and encephalomyelitis. Emerging Microbes & Infections, 6: e62.
  15. Yogarajah T, Ong KC, Perera D, Wong KT. 2017. AIM2 inflammasome-mediated pyrotosis in Enterovirus A71 infected neuronal cells restricts viral replication. Scientific Reports.
  16. Yogarajah T, Ong KC, Perera D, Wong KT. 2017. Enterovirus A71 and Coxsackievirus A16 show different replication kinetics in human neuronal and non-neuronal cell lines. Archives Virology. 162: 727-737.
  17. Chow TK, Eu LC, Chin KF, Ong KC, Pailoor J, Vadivelu J, Wong KT. 2016. Case report: Incidental splenic granuloma due to Burkholderia pseudomallei: A case of asymatic latent meliodosis? Am. J. Trop. Hyg, 94: 522-524.
  18. Fu TL, Ong KC, Tran YD, McLean CA, Wong KT. 2016. Viral neuronotropism is important in the pathogenesis of Murray Valley encephalitis. Neuropathology and Applied Neurobiology. 42: 307-310.
  19. Phyu WK, Ong KC, Wong KT. 2016. A consistently orally-infected hamster model for Enterovirus A71 encephalomyelitis demonstrates squamous lesions in the paws, skin and oral cavity reminiscent of Hand-Foot-and-Mouth Disease. PLOS ONE 11(1): e0147463. doi: 10.1371/journal.pone 0147463
  20. Tan JSJ, Ong KC & Rhodes A (2016). The role of heat shock proteins and glucose regulated proteins in cancer. Malaysia J Pathology 38(2), 75-82.
  21. Tan SH, Ong KC, Perera D, Wong KT. 2016. A monoclonal antibody to ameliorate central nervous system infection and improve survival in a murine model of human Enterovirus-A71 encephalomyelitis. Antiviral Research. 132: 196-203.
  22. Chiam CW, Chan YF, Ong KC, Wong KT, Sam IC. 2015. Neurovirulence comparison of chikungunya virus isolates of the Asia and East/Central/South African genotypes from Malaysia. J Gen Virol. 96: 3243-3254.
  23. Fu TL, Ong KC, Wong KT. 2015. Pathological findings in a mouse model of Japanese encephalitis infected via the foot pad. Neurology Asia, 20: 349-354.
  24. Hooi YT, Ong KC, Perera D, Wong KT. 2015. Pathological findings in a mouse model for Coxsackievirus A16 infection. Neurology Asia, 20: 343-347.
  25. Liu L, Mo Z, Liang Z, Zhang Y, Li R, Ong KC, Wong KT, Yang E, Che Y, Wang J, Dong C, Feng M, Pu J, Wang L, Liao Y, Jiang L, Tan SH, David P, Huang T, Zhou Z, Wang X, Xia J, Guo L, Wang L, Xie Z, Cui W, Mao Q, Liang Y, Zhao H, Na R, Cui P, Shi H, Wang J, Li Q. 2015. Immunity and clinical efficacy of an inactivated enterovirus 71 vaccine in healthy Chinese children: a report of further observations. BMC Med, 13: 226.
  26. Ong KC, Wong KT. 2015. Understanding Enterovirus 71 neuropathogensis and its impact on other neurotropic enteroviruses. Brain Pathol 25:614-24.
  27. Ong KC, Wong KT. Henipavirus encephalitis: Recent developments and advances. Brain Pathology 2015; 25: 605-613
  28. Tan LV, Tuyen NTK, Tan TT, Ngan TT, Van HMT, Sabanathan S, Van TTM, Thanh LTM, Nguyet LA, Geoghegan JL, Ong KC, Perera D, Hang VTT, Ny NTH, Anh NT, Ha DQ, Qui PT, Viet DC, Tuan HM, Wong KT, Holmes EC, Chau NVV, Thwaites G, van Doorn HR. A generic assay for whole-genome amplification and deep sequencing of enteroviurs A71. Journal of Virological Methods 2015; 215-216: 30-36
  29. Thanh TT, Anh NT, Tham NT, Van HMT, Sabanathan S, Qui PT, Ngan TT, Van TTM, Nguyet LA, Ny NTH, Than LTM, Chai OK, Perera D, Viet DC, Khan TH, Ha DQ, Tuan HM, Wong KT, Hung NT, Chau NVV, Thwaites G, van Doorn HR, Tan LV. Validation and utilization of an internally controlled multiplex real-time RT-PCR assay for simultaneous detection of enteroviruses and enterovirus 71 associated hand foot and mouth disease. Virology Journal 2015; 12:85, doi 10.1186/s12985-015-0316-2
  30. Eu LC, Ong KC, Hiu J, Vadivelu J, Nathan S, Wong KT. In situ hybridization to detect and identify Burkholderia pseudomallei in human melioidosis. Modern Pathology 2014; 27: 657-664
  31. He Y, Ong KC, Gao Z, Zhao X, Anderson VM, McNutt MA, Wong KT, Lu M. Tonsillar crypt epithelium is an important extracentral nervous system site for viral replication in EV71 encephalomyelitis. American Journal of Pathology 2014; 184: 714-720
  32. Tan SH, Ong KC, Wong KT. Enterovirus 71 can directly infected the brainstem via cranial nerves and infection can be ameliorated by passive immunization. Journal of Neuropathology and Experimental Neurology 2104; 73: 999-1008
  33. Fujii K, Nagata N, Sato Y, Ong KC, Wong KT, Yamayoshi S, Shimanuki M, Shitara H, Taya C, Koike S. 2013. Transgenic mouse model for the study of enterovirus 71 neuropathogenesis. PNAS, 110: 14753-14758.
  34. Jessie, K., Jayapalan, J. J., Ong, K. C., Rahim, Z. H. A., Zain, R. M., Wong, K. T. and Hashim, O. H. (2013) Aberrant proteins in the saliva of patients with oral squamous cell carcinoma. Electrophoresis, 34, 2495- 2502.
  35. Lee SH, Tang YQ, Rathkrishnan A, Wang SM, Ong KC, Manikam R, Payne BJ, Jaganath IB, Sekaran SD. 2013. Effects of cocktail of four local Malaysian Medicinal plants (Phyllanthus spp.) against dengue virus 2. BMC Complementary & Alternative Medicine, 13: 192.
  36. Ploquin A, Szecsi J, Mathieu C, Guillaume V, Barateau V, Ong KC, Wong KT, Cosset FL, Horvat B, Salvetti A. 2013. Protection against Henipavirus infection by use of recombinant adeno-associated virus-vector vaccines. J Infect Dis, 207: 469-78.
  37. Ch'ng WC, Stanbridge EJ, Wong KT, Ong KC, Yusoff K, Shafee N. 2012. Immunization with recombinant enterovirus 71 viral capsid protein 1 fragment stimulated antibody responses in hamsters. Virol J, 9:155.
  38. Mathieu C, Guillaume V, Sabine A, Ong KC, Wong KT, Legras-Lachuer C, Horvat B. 2012. Lethal Nipah Virus infection induces rapid overexpression of CXCL10. PLos One, 7: e32157.
  39. Wong KT, Ng KY, Ong KC, Ng WF, Shankar SK, Mahadevan A, Radotra B, Su IJ, Lau G, Ling AE, Chan KP, Macorelless P, Vallet S, Cardosa MJ, Desai A, Ravi V, Nagata N, Shimizu H, Takasaki T. 2012. Enterovirus 71 encephalomyelitis and Japanese encephalitis can be distinguished by topographic distribution of inflammation and specific intraneuronal detection of viral antigen and RNA. Neuropathology and Applied Neurobiology. 38: 443-53.
  40. Ch'ng WC, Stanbridge EJ, Ong KC, Wong KT, Yussof K, Shafee N. 2011. Partial Protection Against Enterovirus 71 (EV71) Infection in a Mouse Model Immunized With recombinant Newcastle Disease Virus Capsids Displaying the EV71 VP1 Fragment. JOURNAL OF MEDICAL VIROLOGY. 83: 1783-91.
  41. Wong KT & Ong KC. 2011. Pathology of acute henipavirus infection in humans and animals. Pathology Research International, 2011: 567248.
  42. Ong KC, Devi S, Cardosa MJ, Wong KT. 2010.Formaldehyde- inactivated whole-virus vaccine protects a murine model of enterovirus 71. J. Virol. 84: 661-5.