PERSONAL DETAIL


PROF. DR. HANY BINTI MOHD ARIFFIN

Department of Paediatrics
Faculty of Medicine
 
  +603-79492065
  +603-7949 4704
  hany@um.edu.my
 Department of Paediatrics, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, W.Persekutuan Kuala Lumpur, Malaysia
 
ResearcherID Link
  http://www.researcherid.com/rid/B-8590-2010


BIBLIOMETRIC DATA


 Total Articles in Publication List  76
 Articles With Citation Data  76
 Sum of the Times Cited   1040
 Average Citations per Article   13.68
 h-index   16
 Co-authors   Collaboration Network
 This information is generated from http://researcherid.com

BIOGRAPHY


Professor Hany Ariffin  is  Professor of Paediatrics and Head of the Division of Paediatric Haematology-Oncology and Bone Marrow Transplantation at the University of Malaya Medical Centre (UMMC). She also heads the Biobank Unit in the Faculty of Medicine, UM.  Her main research interest is childhood leukaemia and she has been the Malaysian lead for the Malaysia-Singapore (MASPORE) Leukaemia Study Group since 2003. Her other research areas include childhood cancer survivorship, stem cell transplantation and inherited cancers, particularly related to mutations in the tumour suppressor gene, TP53. She is a member of the UMMC Medical Ethics Committee, hospital Clinical Ethics Committee as well as the paediatric oncology accreditation committee for the National Specialist Register.  Professor Hany is the immediate past  president of the Malaysian Society of Paediatric Haematology-Oncology where together with colleagues in the local fraternity, works to improve the outcome of children with cancer in Malaysia whilst ensuring equitable treatment for all irrespective of socio-economic standing. 

 

 

 


ACADEMIC QUALIFICATION
(Qualification), (Institution).



PROFESSIONAL
(Organisation), (Role), (Year), (Level).


  • INTERNATIONAL UNION AGAINST CANCER (UICC), Fellow, 2002, (International)
  • INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY (SIOP), Member, 2002, (International)
  • Malaysian Society of Paediatric Haematology-Oncology, President, 2011, (National)
  • Royal College of Paediatrics and Child Health, Fellow, 2011, (International)

ADMINISTRATIVE DUTIES
(Role), (Level), (Start date),(End Date).


  • Head, University of Malaya Cancer Research Institute (Umcri), Faculty of Medicine, 01/01/2015 to 31/12/2015
  • Faculty Representative , UM Higher Degree Examiners Committee, University Malaya,  
  • Head, Biobank Unit, Faculty,  
  • Committee Member, Selection Panel, UM Bright Sparks/SLAB/SLAI Program, University Malaya,  
  • Committee Member, Research Grant Evaluation Panel, University Malaya,  

AREAS OF EXPERTISE
(Area).


  • Haematology (Acute Leukemia)
  • Oncology (Paediatric oncology)


RECENT SELECTED PUBLICATIONS
(Publication).


Book

1996
  • Hamzah Sendut I, Ismail Z, Ariffin H. 1996. Pediatric Picture Tests for Medical Students. Kuala Lumpur, Pelanduk Publications (Non-ISI/Non-SCOPUS)
Chapter in Book

2005
  • Hany Ariffin, 2005. \"Febrile Neutropenia\" in Lee WS, Thong MK, Wong CP (eds) Handbook of Hospital Pediatrics, pp 159-61 (Non-ISI/Non-SCOPUS)
  • Hany Ariffin, 2005. \" Usage of Blood Products\" in LeeWS , ThongMK, Wong CP (eds)Handbook of Hospital Pediatrics. pp 154-6. (Non-ISI/Non-SCOPUS)
  • Hany Ariffin, 2005. \'Thalassemias\' in Lee WS, Thong MK, Wong CP (eds), Handbook of Hospital Pediatrics.pp156-9 (Non-ISI/Non-SCOPUS)
Article in Academic Journals

2019
  • Li CK. (2019). Care of adolescents and young adults with cancer in Asia: results of an ESMO/ SIOPE/SIOP Asia survey. ESMO Open 2019;4:e000467. (SCOPUS-Indexed)
  • Ariffin H (2019). Challenges in Surviving Childhood Leukaemia. Lancet Haematology, 6(6): e288-9 (ISI-Indexed)
  • Oh,L, Hafsi H, Hainaut P, Ariffin H. (2019). p53, stem cell biology and childhood blastomas. Current Opinion Oncology, 31: 84-91 (ISI-Indexed)

2018
  • Yeoh AEJ, et al. Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study. J Clin Oncol 2018; 36(26): 2726-35 (ISI-Indexed)
  • Chin TF, Ibrahim K, Thirunavakarasu T, Azanan MS, Oh L, Lum SH, Yap TY, Ariffin H (2018) Nonclonal Chromosomal Aberrations in Childhood Leukemia Survivors, Fetal Pediatric Pathology, 1:1-11 (ISI-Indexed)
  • Li, JF et al (2018). Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.Proc Natl Acad Sc , 115(50): 11711-11720 (ISI-Indexed)
  • Yeoh AE, Li Z, Dong D, Lu Y, Jiang N, Trka J, Tan AM, Lin HP, Quah TC, Ariffin H, Wong L. Effective Response Metric: a novel tool to predict relapse in childhood acute lymphoblastic leukaemia using time-series gene expression profiling. British Journal of Haematology 2018; 181: 653-663 (ISI-Indexed)

2017
  • Ariffin, H., Azanan, M. S., Abd Ghafar, S. S., Oh, L., Lau, K. H., Thirunavakarasu, T., . . . Hainaut, P. (2017). Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging. Cancer, 123(21), 4207-4214. (ISI-Indexed)
  • Chua LL, Rajasuriar R, Azanan MS, Abdullah NK, Tang MS, Lee SC, Woo YL, Lim YA, Ariffin H, Loke P.. Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation. Microbiome. 2017;5(1):35. (ISI-Indexed)
  • Moriyama T, et al. (2017). Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry. Blood 130(10): 1209-13 (ISI-Indexed)
  • Tay CG, Lee VW, Ong LC, Goh KJ, Ariffin H, Fong CY. (2017). Vincristine-induced peripheral neuropathy in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer; Aug; 64(8). doi. 10.1002/pbc.26471. (ISI-Indexed)
  • Hu S, Qian M, Zhang H, et al. (2017). Whole genome non-coding sequence analysis of T-cell acute lymphoblastic leukemia identifies oncogene enhancer mutations. Blood 129(24): 3264-3268 (ISI-Indexed)
  • Qian M, et al. (2017) Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP (ISI-Indexed)

2016
  • Azanan MS, Abdullah NK, Chua LL, Lum SH, Abdul Ghafar SS, Kamarulzaman A, Kamaruzzaman S, Lewin SR, Woo YL, Ariffin H, Rajasuriar R. Immunity in young adult survivors of childhood leukemia is similar to the elderly rather than age-matched controls: Role of cytomegalovirus. Eur J Immunol. 2016 Jul;46(7):1715-26 (ISI-Indexed)
  • Rajagopal R, Abd-Ghafar S, Ganesan D, Bustam Mainudin A.Z., Wong K.T., Ramli N, Jawin V, Lum S.H., Yap T.Y., Bouffet E, Qaddoumi I, Krishnan S, Ariffin H and Abdullah W.A. 2016. Challenges of Treating Childhood Medulloblastoma in a Country With Limited Resources: 20 Years of Experience at a Single Tertiary Center in Malaysia. Journal of Global Oncology June 15, 2016, doi: 10.1200/JGO.2015.002659 (ISI-Indexed)
  • Lum SH, Choong SS, Krishnan S, Mohamed Z, Ariffin H. 2016. GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder. Singapore Med J 57(6):320-324 (ISI-Indexed)
  • Su Han Lum, Shi Jie How, , Hany Ariffin, Shekhar Krishnan. A four-point clinical criteria distinguishes immune thrombocytopenia from acute lymphoblastic leukaemia. Med J Malaysia 2016; 71(1): 28-9 (SCOPUS-Indexed)

2015
  • Rajagopal R, Ariffin H, Krishnan S, Abdullah WA, Lin HP.2015. Pediatric Vaginal Yolk Sac Tumor: Reappraisal of Treatment Strategy in a Rare Tumor at a Unique Location.J Pediatr Hematol Oncol. 2015 Jul;37(5):391-5 (ISI-Indexed)
  • Tay CG, Ariffin H, Yap S, Rahmat K, Sthaneshwar P, Ong LC. 2015. Succinic Semialdehyde Dehydrogenase Deficiency in a Chinese Boy: A Novel ALDH5A1 Mutation With Severe Phenotype.J Child Neurol ;30(7):927-31 (ISI-Indexed)
  • Ariffin H, Chan AS, Oh L, Abd-Ghafar S, Ong GB, Mohamed M, Razali H, Juraida E, Teo SH, Karsa M, Shamsani J, Hainaut P.2015. Frequent occurrence of gastric cancer in Asian kindreds with Li-Fraumeni syndrome.Clin Genet. 2015 Nov;88(5):450-5 (ISI-Indexed)
  • Tay C.G., Ariffin, H., Yap, S., Rahmat, K., Sthaneshwar, P., Ong, L.C. (2014). Succinic semialdehyde dehydrogenase deficiency in a chinese boy: A novel ALDH5A1 mutation with severe phenotype. Journal of Child Neurology, 30(7),927-31. (ISI-Indexed)

2014
  • Ariffin H, Hainaut P, Puzio-Kuter A, et al. Whole- genome sequencing analysis of phenotypic heterogeneity and anticipation in Li Fraumeni cancer predisposition syndrome. Proc Nat Acad Sc 2014 ; 111(43): 15497-501 (ISI-Indexed)
  • Lum SH, Chin TF, Lau KH, Yap TY, Rajagopal R, Ariffin H. Refractory acute monoblastic leukaemia with low hypodiploidy. Int J Hematol. 2014; 99(3): 215-6 (ISI-Indexed)
  • Ariffin H, Geikowski A, Chin TF, Chau D, Arshad A, Abu Bakar K, Krishnan S. Griscelli syndrome. Med J Malaysia. 2014 ; 69(4):193-4 (SCOPUS-Indexed)
  • Lu Y, Kham SK, Ariffin H, et al. Host genetic variants of ABCB1 and IL15 influence treatment outcome in paediatric acute lymphoblastic leukaemia. Br J Cancer. 2014 ; Jan 16 (epub ahead of print) (ISI-Indexed)

2013
  • Rajagopal R, Lum SH, Jalaludin MY, Krishnan S, Abdullah WA, Ariffin H. Hypercalcaemia: an unusual presenting feature of childhood acute lymphoblastic leukaemia. Br J Haematol. 2013 ; 163(2):147 (ISI-Indexed)
  • Yan J, Jiang N, Huang G, Tay JL, Lin B, Bi C, Koh GS, Li Z, Tan J, Chung TH, Lu Y, Ariffin H, Kham SK, Yeoh AE, Chng WJ. Deregulated MIR335 that targets MAPK1 is implicated in poor outcome of paediatric acute lymphoblastic leukaemia. Br J Haematol 2013; 163(1): 93-103 (ISI-Indexed)

2012
  • Lee DS, Yoon SY, Looi LM, Kang P, Kang IN, Sivanandan K, Ariffin H, Thong MK, Chin KF, Mohd Taib NA, Yip CH, Teo SH. Comparable frequency of BRCA1, BRCA2 and TP53 germline mutations in a multi-ethnic Asian cohort suggests TP53 screening should be offered together with BRCA1/2 screening to early-onset breast cancer patients. Breast Cancer Res. 2012 Apr 16;14(2):R61. (ISI/SCOPUS Indexed Publication)
  • KB Loh, Ramli N, LK Tan, M Roziah, Rahmat K, Ariffin H. Quantification of diffusion tensor imaging in normal white matter maturation of early childhood using an automated processing pipeline. EUROPEAN RADIOLOGY Volume: 22 Issue: 7 Pages: 1413-1426 Mar 22.[Epub print ] (IF 4.34 Q1) (ISI-Indexed)
  • Yeoh AE, Ariffin H, Chai EL, et al.Minimal residual disease-guided treatment deintensification for children with acute lymphoblastic leukemia: results from the malaysia-singapore acute lymphoblastic leukemia 2003 study. J Clin Oncol 2012; 30(19): 2384-92 (ISI-Indexed)
  • Lim L, Chen KS, Krishnan S, Gole L, Ariffin H. Mature B- cell acute lymphoblastic leukaemia associated with a rare MLL-FOXO4 fusion gene. Br J Haematol. 2012 Mar 19. doi: 10.1111/j.1365-2141.2012.09091.x.[Epub ahead of print] (ISI-Indexed)
  • Choong S, Latiff Z, Mohamed M, Lim L, Chen K, Vengidasan L, Razali H, Abdul Rahman E, Ariffin H; for Malaysian Society of Paediatric Haematology- Oncolody. Childhood adrenocortical carcinoma as a sentinel cancer for detecting families with germline TP53 mutations.Clin Genet. 2012 ;82(6):564-8 (ISI-Indexed)

2011
  • Madhloom HT, Kareem SA, Ariffin H. An Image Processing Application for the Localization and Segmentation of Lymphoblast Cell Using Peripheral Blood Images. J Med Syst. 2011 Mar 12. [Epub ahead of print] (ISI-Indexed)
  • Choong SS, Rosmanizam S, Ibrahim K, Gan GG, Ariffin H. Development of an algorithm of satellite markers for monitoring chimerism status in post-allogeneic haematopoietic stem cell transplantation patients. Int J Lab Hematol. 2011;33(2):182-6 (ISI-Indexed)
  • Jiang N, Kham SK, Koh GS, Suang Lim JY, Ariffin H, Chew FT, Yeoh AE.Identification of prognostic protein biomarkers in childhood acute lymphoblastic leukemia (ALL). J Proteomics. 2011; 74(6):843-57 (ISI-Indexed)
  • Leow S, Kham SK, Ariffin H, Quah TC, Yeoh AE. FLT3 mutation and expression did not adversely affect clinical outcome of childhood acute leukaemia-a study of 531 Southeast Asian children by the Ma-Spore study group.Hematol Oncol. 2011;29(6):211-9 (ISI-Indexed)
  • Jiang N, Koh GS, Suang Lim JY, Yin Kham SK, Ariffin H, Chew FT, Yeoh AE. BIM is a prognostic biomarker for early prednisolone response in pediatric acute lymphoblastic leukemia. Exp Hematol. 2011 Mar;39 (3):321-329 (ISI-Indexed)

2010
  • Chong SY, Chong LA, Ariffin H. Accurate prediction of the needle depth required for successful lumbar puncture. Am J Emerg Med 2010 ; 28: 603-6 (ISI-Indexed)
  • IC Sam, Abdul-Murad A, Karunakaran R, Rampal S, Chan YF, Nathan AM, Ariffin H. Clinical features of Malaysian children hospitalised with community-acquired seasonal influenza. IJID 14S(2010)e36-e40 (ISI-Indexed)
  • Yeoh AE, Lu Y, Chan JY, Chan YH, Ariffin H, Kham SK, Quah TC. Genetic susceptibility to childhood acute lymphoblastic leukemia shows protection in Malay boys: Results from the Malaysia-Singapore ALL Study Group. Leuk Res. 2010;34(3):276-283 (ISI-Indexed)
  • Daud SS, Ibrahim K, Choong SS, Vengidasan L, Chong LA, Daud SS, Ibrahim K, Choong SS, Vengidasan L, Chong LA, Ariffin H, . Microfluidic chip-based assayfor post- hematopoietic stem cell transplantation chimerism monitoring using polymorphic tandem repeat markers. Anal Biochem 2010; 397(2):181-5 (ISI-Indexed)

2009
  • Ariffin H, Garcia JC, Daud SS, Ibrahim K, Aizah N, Ong GB, Chong LA, Mohamad Z, 2009. GATA1 mutations in patients with Down syndrome and acute megakaryoblastic leukaemia do not always confer a good prognosis.Pediatr Blood Cancer. 2009 Jul;53(1):108-11. (ISI-Indexed)
  • Patel N, Krishnan S, Offman MN, Krol M, Moss CX, Leighton C, van Delft FW, Holland M, Liu J, Alexander S, Dempsey C, Ariffin H, Essink M, Eden OB, Watts C, Saha V. A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L- asparaginase. J Clin Invest 2009 ; 119 (7) : 1964-73 (ISI-Indexed)

2008
  • Ibrahim K, Daud SS, Seah YL, Yeoh AE, Ariffin H. Rapid detection of prognostically important childhood ALL chimeric transcripts using multiplex SYBR-Green reverse transcription real-time PCR. Ann Clin Lab Sci 2008; 38(4): 338 -43 (ISI-Indexed)
  • Mah ESL, Muridan R, Cheng PS, Ariffin H, Ramanujam TM. Supratentorial primitive neuroectodermal tumour with thoracic metastases. J Pediatr Neurol 2008 ; 6(2): (Non-ISI/Non-SCOPUS)
  • Ariffin H, Martel-Planche G, Daud SS, Ibrahim K, Hainaut P. Li-Fraumeni Syndrome in a Malaysian kindred 2008 ; 186(1): 49-53 (ISI-Indexed)
  • Kham SK, Soh CK, Liu TC, Chan YH, Ariffin H, et al. Thiopurine S-methyltransferase activity in three major Asian populations : a population-based study in Singapore. Eur J Clin Pharmacol 2008 ; 64(4) : 373 - 9 (ISI-Indexed)

2007
  • Ariffin H, Daud SS, Mohamed Z, et al. Evaluation of two short tandem repeat multiplex systems for post haematopoietic stem cell transplantation chimerism analysis. Singapore Med J 2007: 48(4) : 333 7 (SCOPUS-Indexed)
  • Daud SS, Ibrahim K, Ariffin H. Quantitative evaluation of chimerism status following stem cell transplantation using a microchip electrophoresis system. JUMMEC 2007; 10(1): 11-16 (Non-ISI/Non-SCOPUS)
  • Ariffin H, Chen SP, Kwok CS, Quah TC, Lin HP, Yeoh AE; for the Malaysia-Singapore Leukemia Study Group. Ethnic Differences in the Frequency of Subtypes of Childhood Acute Lymphoblastic Leukemia: Results of the Malaysia-Singapore Leukemia Study Group. J Pediatr Hematol Oncol 2007 ; 29(1) : 27 -31 (ISI-Indexed)
  • Sithasanan N, Chong LA, Ariffin H. Spontaneous splenic rupture secondary to phaeohyphomycosis and splenic abscess. Med J Malaysia 2007; 62(3) : 247 8 (ISI-Indexed)
  • Lu Y, Kow-Yin Kham S, Foo TC, Hany A, Quah TC, Yeoh A. Genotyping of eight polymorphic genes encoding drug-metabolizing enzymes and transporters using a customized oligonucleotide array. Anal Biochem. 2007; 360(1):105-13. (ISI-Indexed)
  • Reid S, Schindler D, Hanenberg H, Barker K, Hanks S, Kalb R, Neveling K, Kelly P, Seal S, Freund M, Wurm M, Batish SD, Lach FP, Yetgin S, Neitzel H, Ariffin H, Tischkowitz M, Mathew CG, Auerbach AD, Rahman N. Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer. Nat Genetics 2007; 39(2): 162 -4 (ISI-Indexed)
  • Menon BS, Juraida E, Alagaratnam J, Mohammad M, Ibrahim H, George TM, Ariffin H, Ho C, Khuzaiah R, Lin HP; for the Malaysian Children\'s Cancer Study Group. Chemoreduction for Intraocular Retinoblastoma in Malaysia. J Pediatr Hematol Oncol 2007 ; 29(1) : 2-4 (ISI-Indexed)

2006
  • Kwok CS, Kham SK, Ariffin H, et al. Minimal residual disease (MRD) measurement as a tool to compare the efficacy of chemotherapeutic drug regimens using Escherichia Coli-asparaginase or Erwinia-asparaginase in childhood acute lymphoblastic leukemia (ALL). Pediatr Blood Cancer 2006 ; 47(3) : 299 ¿ 304 (ISI-Indexed)
  • Ariffin H, Chong LA, Chan LL, Abdullah WA. Cefepime monotherapy for treatment of febrile neutropenia in children. J Paed Child Health 2006 ; 42(12) : 781 ¿ 4 (ISI-Indexed)

2005
  • Ariffin H , Lum SH , Cheok SA, et al. Haemophagocytic lymphohistiocytosis in Malaysian children . J Paediatr Child Health 2005 ; 41(3) : 136-9 (ISI-Indexed)
  • Ariffin H, Muthukkumaran T, Stanslas J , et al . Secondary acute lymphoblastic leukaemia following Wilms¿ tumour: clinical and in vitro chemosensitivity studies. Leuk Lymphoma 2005: 46(8): 1233 ¿7 
  • Ariffin H , Lim HL . Surveillance blood counts for early detection of relapse in acute lymphoblastic leukemia. Pediatr Blood Cancer 2005 ; 45(2) : 229 (ISI-Indexed)

2004
  • Ariffin H, et al. , \"Antibiotic resistance patterns in nosocomial gram-negative bacterial infections in units with heavy antibiotic usage \", 2004, J Trop Pediatr, Vol. 50, no. 1, pg. 26-31 

2003
  • Ariffin H, \"Severe vincristine neurotoxicity with concomitant use of itraconazole \", 2003, J Paediatr Child Health, Vol. 39, no. 8, pg. 638 
  • Ariffin H, et al, \"Prenatal exclusion of severe Factor VII deficiency \", 2003, J Pediatr Hematol Oncol, Vol. 25, no. 5, pg. 418-20 
  • Ariffin H, et al, \"Validation of a multiplex RT-PCR assay for screening significant oncogene fusion transcripts in children with acute lymphoblastic leukaemia \", 2003, Singapore Med J, Vol. 44, no. 10, pg. 517-20 (ISI-Indexed)

2002
  • Ariffin H , Parasakthi N , Lin HP, \"Surveillance study of bacteremic episodes in febrile neutropenic children\", Int J Clin Pract 2002, Vol. 56, no. 4, pg. 237-40 (ISI-Indexed)
  • Ariffin H , Parasakthi N , Lin HP. Surveillance study of bacteremic episodes in febrile neutropenic children . Int J Clin Practice 2002 ; 56(4) : 237 - 40 (ISI-Indexed)
  • Ariffin H . Late effects of childhood cancer therapy . J Paed Obst Gynaecology 2002 ; 28(5) : 5 -9 (Non-ISI/Non-SCOPUS)

2001
  • 14) Ariffin H , Arasu A , Mahfuzah M , et al. Single-daily ceftriaxone plus amikacin vs thrice-daily ceftazidime plus amikacin as empirical treatment of febrile neutropenia in children with cancer . J Paed Child Health 2001; 37(1) :38 - 43 (ISI-Indexed)

2000
  • Omar KZ , Ariffin H , Ariffin WA , Chan LL , Lin HP . Streptokinase infusion for asparaginase-induced arterial thrombosis . Med Pediatr Oncol 2000 ; 34(5) : 377-8 (ISI-Indexed)
  • Ariffin H , Ariffin WA , Chan LL, Lin HP. Wilms\' tumour and Fanconi anemia ; an unusual association . J Paed Child Health 2000 ; 36(2) : 196-7 (ISI-Indexed)
  • Parasakthi N , Vadivelu J , Ariffin H , Iyer L , Selvi P , Arasu A . Epidemiology and molecular characterisation of nosocomially-transmitted multi-resistant Klebsiella pneumoniae . Int J Infect Dis 2000 ; 4 : 123 -8 (ISI-Indexed)
  • Omar KZ, Ariffin H , Lin HP , Ariffin WA , Chan LL . Complications of L-asparaginase therapy in childhood leukemia . Int J Ped Hematol Oncol 2000 ; 7 (3) : 225 - 33 (ISI-Indexed)

1999
  • Chan LL , Lin HP , Ariffin WA , Ariffin H , Saw MH. Treating high-risk childhood solid tumours with autologous peripheral stem-cell transplantation -- early experience in University Hospital , Kuala Lumpur. Med J Malaysia 1999: 54 (2): 175-9 (ISI-Indexed)
  • Ariffin H , Ariffin WA , Omar A , deBruyne JA , Chan LL , Lin HP . Successful treatment of Candida albicans endocarditis in a child with leukemia . Singapore Med J 1999 ; 40 (8) : 533 - 6 (ISI-Indexed)
  • Ariffin H , Parasakthi N, Mahfuzah M , Arasu A , Ariffin WA , Chan LL , Lin HP . Ceftazidime-resistant Klebsiella pneumoniae bloodstream infection in children with febrile neutropenia . Int J Infect Dis 1999 ; 4 : 21 - 25 (ISI-Indexed)
  • Ariffin H , Ariffin WA , Mahfuzah M , Arasu A , Lin HP . Treatment of systemic Fusarium infection in children with leukemia . Med Pediatr Oncol 1999 ; 33 (6) : 598 - 9 (ISI-Indexed)

1998
  • Mahfuzah M , Ariffin H , Arasu A , Soo-Hoo TS , Ariffin WA , Lin HP . Systemic Fusarium infection in children with cancer ; a report of two cases . Malaysian J Child Health 1998 ; 10(2) : 55-7 (Non-ISI/Non-SCOPUS)

1997
  • Ariffin H , Ariffin WA , Chan LL , Lam SK , Lin HP . Second malignant neoplasms : An increasingly- recognised complication in childhood cancer survivors . Med J Malaysia 1997 ; 52 (2 ) : 174 77 (SCOPUS-Indexed)
  • Ariffin H , Ariffin WA , Lin HP , Parasakthi N . Septicemia in paediatric cancer patients : A 5-year surveillance study . J Trop Paediatr 1997 ; 45 (3) : 279 - 81 (ISI-Indexed)
  • Ariffin H , Ariffin WA , de Bruyne JA , Chan LL , Lam SK , Lin HP . Belief in traditional healers amongst Malaysian parents of children with cancer. J Trop Paediatr 1997 ; 43 : 375 - 6 . (ISI-Indexed)
  • Ariffin H , Ariffin WA , Wong KT ,Raman TM , Lin HP. Intra-abdominal desmoplastic small round cell tumour in an 11-year old boy . Singapore Med J 1997; 38:169 - 71 (ISI-Indexed)
  • Ariffin H , Lin HP. Neonatal intracranial haemorrhage secondary to congenital factor VII deficiency : Two case reports . Am J Hematology 1997 ; 54 (3) : 263 (ISI-Indexed)

1996
  • A Hany , Thong MK , Lin HP. Two brothers in a Malaysian family with the X - linked ymphoproliferative disease. Singapore Med J 1996 : 37 : 325 - 7 (SCOPUS-Indexed)
  • Hany A, Thong MK, Lin HP. X-linked lymphoproliferative disease in a Malaysian family. Singapore Med. Journal 1996; 37: 325-7. (SCOPUS-Indexed)
Technical Report

2006
  • Ariffin H and others(eds) . Clinical Practice Guidelines on the management of Immune Thrombocytopenia Purpura. 2006; Joint publication by the Ministry of Health , Malaysia & Academy of Medicine Malaysia (Non-ISI/Non-SCOPUS)

2001
  • Parasakthi N and Ariffin H (eds) . Consensus Guidelines on the management of infections by ESBL-producing bacteria. 2001; Joint publication by the Ministry of Health , Malaysia , Academy of Medicine Malaysia and Malaysian Society of Infectious Diseases and Chemotherapy (MSIDC) (Non-ISI/Non-SCOPUS)

AREAS OF RESEARCH
(Project title), (Role), (From)-(Until), (Level), (Source).


  • Dental Approaches For Paediatric Oncology Patients: Characteristics Of The Population Treated At The Paedatric Dentistry Clinic, University Of Malaya Medical Centre, Consultant, 2019 - 2021, Others MOHE - Top 100 (IIRG)-HWB, (National)
  • Improving Survical Quality Of Childhood Cancer Via Safer And More Effective Hla-haploidentical Haemopioetic Stem Cell Transplantatio, Principal Investigator(PI), 2019 - 2021, Others MOHE - Top 100 (IIRG)-HWB, (National)
  • Immune and Cellular Therapies for Childhood Cancers, Principal Investigator(PI), 2019 - 2020, Partnership Grant, (National)
  • Molecular Characterization And Associated Clinical Manifestation Of Opportunistic Pathogenic Organisms Among Immunocompromised Children With Cancer, Consultant, 2019 - 2021, Others MOHE - Top 100 (IIRG)-HWB, (National)
  • Improving Survival Quality Of Childhood Cancer Via Lifestyle Modifications, Consultant, 2019 - 2021, Others MOHE - Top 100 (IIRG)-HWB, (National)
  • Integrative lncRNA-miRNA-mRNA regulatory network analysis in human thymic epithelial tumors, Consultant, 2018 - 2020, Bantuan Kecil Penyelidikan (BKP), (National)
  • Personalized Thiopurine Dosing In Children With Acute Lymphoblastic Leukemia (all) Using Tpmt And Nudt15 Genotype Status, Consultant, 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness), (University)
  • P53 Isoforms As New Therapeutic Target In Childhood Cancers, Consultant, 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness), (University)
  • Elucidating The Aetiology Of Second Cancers In Childhood Cancer Survivors, Principal Investigator(PI), 2017 - 2019, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness), (University)
  • Paediatric Acute Myeloid Leukemia, Principal Investigator(PI), 2016 - 2020, Private Funding, (National)
  • Cytogenetic risk stratification of childhood Acute Lymphoblastic Leukaemia using Karyotyping and Fluorescent In-Situ Hybridization, Consultant, 2016 - 2018, Bantuan Kecil Penyelidikan (BKP), (National)
  • Neuro-cognitive outcome of children treated for acute lymphoblastic leukemia; implications for future employability, Principal Investigator(PI), 2013 - 2014, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness), (University)
  • 'PERIPHERAL NEUROPATHY IN SURVIVORS OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA, Co-Investigator, 2012 - 2014, BKP, (National)
  • Research On Cancers In The Malaysian Population: Saving Lives Through Innovation And Collaboration (umcri)., Principal Investigator(PI), 2011 - 2016, High Impact Research - Ministry of Education (HIR-MOE) Cycle 1, (National)
  • Using Next Generation Sequencing Technologies To Determine The Genetic And Environmental Drivers For Cancer Progression And Metastases, Principal Investigator(PI), 2011 - 2016, High Impact Research - Ministry of Education (HIR-MOE) Cycle 1, (National)
  • MASPORE ALL 2010, Principal Investigator(PI), 2010 - 2017, NUS, (National)
  • Development of a robust chimerism analysis system following stem cell transplantation, Principal Investigator(PI), 2008 - 2010, MOSTI, (National)
  • Li-Fraumeni Syndrome in Malaysia, Principal Investigator(PI), 2008 - 2010, IARC,WHO, (National)
  • MASPORE AML, Principal Investigator(PI), 2007, NUS, (National)
  • WT-1 gene in acute myeloid leukemia, Coordinator, 2007 - 2008, MOHE, (University)
  • Expression of TERF-2 and hTERT in childhood acute lymphoblastic leukemia, Coordinator, 2007 - 2008, MAKNA, (University)
  • Asparaginyl endopeptidase in childhood cancer, Principal Investigator(PI), 2007 - 2008, MOHE, (National)
  • Quantitative chimerism analysis using microchip electrophoresis system, Principal Investigator(PI), 2006 - 2008, MOHE, (University)
  • Malaysia-Singapore AML2006 Study, Principal Investigator(PI), 2006 - 2008, MOHE, (International)
  • Oncogene Fusion Transcripts in Acute Lymphoblastic Leukemia, Principal Investigator(PI), 2005 - 2008, , (University)
  • Chimerism analysis using short tandem repeats, Principal Investigator(PI), 2005 - 2006, Short Term Research Fund (Vote F)(PJP), (University)
  • Malaysia-Singapore Acute Lymphoblastic Leukemia Study, Co-Investigator, 2003 - 2008, Singapore Cancer Syndicate, AStar, (International)
  • Minimal Residual Disease assessment via flow cytometry, Principal Investigator(PI), 2000 - 2002, MAKNA, (University)
  • Asparaginyl endopeptidase and childhood cancer
  • Childhood Leukemias
  • WT-1 gene in acute myeloid leukemia
  • Chimerism analysis techniques following haemopoeitic stem cell transplantation

CONSULTATION PROJECT/CONSULTANCY
(Project title), (Role), (From)-(Until), (Organisation).


  • Chimerism analysis following bone marrow transplantation, 2007-2007, Sime Darby Technology Corp

AWARDS AND RECOGNITIONS
(Name of Award), (Awarding Institution), (Year Awarded), (Level).


  • Distinguished Researcher , University of Malaya, 2018, (University)
  • Excellence Service Award, University Malaya, 2017, (University)
  • Khidmat Setia 20 Award, 2015
  • Um Excellence Award, Naib Canselor, 2015, (University)
  • Anugerah Akademik Negara, Kementerian Pengajian Tinggi, 2015, (National)
  • Um Excellence Award, 2012, (University)
  • Certificate of Excellent Service, University Malaya, 2011, (University)
  • Excellence Service Award, University Malaya, 2008, (University)
  • Certificate of Excellent Service, University Malaya, 2007, (University)
  • Certificate of Excellent Service, University Malaya, 2006, (University)
  • Uicc (International Union Against Cancer) Fellowship, Cancerresearch-Uk Clinical Centre, London, United Kingdom, 2006, (International)
  • Certificate of Excellent Service, University Malaya, 2005, (University)
  • Excellence Service Award, University Malaya, 2005, (University)
  • Certificate of Excellent Service, University Malaya, 2004, (University)
  • Uicc (International Union Against Cancer) Fellowship, Sir James Spence Institute of Child Health , Royal Victoria Infirmary , Newcastle-Upon-Tyne, 2002, (International)
  • Cancer Research Award, National Cancer Council of Malaysia (Makna), 2001, (National)
  • Young Investigator Travel Scholarship, International Society of Paediatric Oncology (Siop), 2000, (International)
  • Bill Marshall Memorial Fellowship, Great Ormond Street Hospital and Institute of Child Health, London, 2000, (International)
  • Young Investigator Award, International Society for The Immunocompromised Host, 1998, (International)
  • Postgraduate Merit Award, Malaysian Paediatric Association, 1998, (National)
  • Young Investigator Travel Award, International Society of Chemotherapy, 1997, (International)

PRESENTATIONS
(Title), (Event), (Date Presented), (Organiser), (Level).


INVITED SPEAKER
  • Adjuvant chemotherapy in childhood brain tumours, National Conference of Neurosurgical Association of Malaysia, 2007-06-07 to 2007-06-09, Neurosurgical Association of Malaysia, (National)
  • Acute Myeloid Leukemia ; Malaysia-Singapore Study , St Jude Asia Forum 2008, 2008-03-04 to 2008-04-07, Viva Foundation, Singapore and St Jude Outreach, (International)
  • Engraftment studies following haemopoetic stem cell transplantation, Transplant Pathology Updates,Malaysian College of Pathologists, 2011-06-18 to 2011-06-19, Malaysian College of Pathologists, (National)
  • Risk stratification of childhood leukemia, 7th Biennial Congress of International Society of Paediatric Oncology (SIOP, Asia), 2012-04-22 to 2012-04-24, International Society of Paediatric Oncology (SIOP, Asia), (International)
  • Haematological Disorders in Children with Down Syndrome, Seminar on Paediatric Haematology, 2012-05-10 to 2012-05-11, Malaysian Society of Paediatric Haematology-Oncology, (National)
  • Estimating the prevalence in Li-Fraumeni syndrome, "Heterogeneity and Anticipation in Li-Fraumeni Syndrome", 2012-12-06 to 2012-12-07, Institute for Advance Study, Princeton, New Jersey, USA, (International)
  • Inflammation and Cancer, 9th Congress of the Asian Society of Paediatric Research, 2013-05-11 to 2013-05-12, Asian Society of Paediatric Research, (International)
  • Tumour Lysis Syndrome, 24th Annual Scientific Meeting of Malaysian Society of Paediatric Haematology-Oncology, 2013-09-21 to 2013-09-22, Malaysian Society of Paediatric Haematology-Oncology, (National)
  • Personalized therapy in childhood ALL, 1st National Conference for Cancer Research, 2013-11-08 to 2013-11-10, (National)
  • Li-Fraumeni Syndrome : The Malaysian Experience, Annual Scientific Meeting of Malaysian Oncological Society 2013, 2013-11-29 to 2013-11-30, Malaysian Oncological Society , (National)
POSTER
  • Long-term sequelae in childhood cancer survivors, 33rd Meeting of the International Society of Paediatric Oncology (SIOP) . Brisbane, 10-13 October 2001, 2001-10-10 to 2001-10-13, International Society of Paediatric oncology (SIOP), (International)
  • Primary intra-cranial germ-cell tumours ; 12-year experience from University of Malaya, 10th International Symposium of Paediatric Neuro-Oncology , 2002-06-10 to 2002-06-12, International Society of Paediatric Neuro-Oncology, (International)
  • Haemophagocytosis in children, Haemophagocytosis in Malaysian Children . 26th Annual Congress of the Malaysian Paediatric Association. , 2004-09-02 to 2004-09-04, Malaysian Pediatric Association, (National)
  • Mortality in Children with Acute Lymphoblastic Leukemia . , 36th Meeting of the International Society of Paediatric Oncology (SIOP) , 2004-09-15 to 2004-09-19, International Society of Paediatric Oncology (SIOP) , (International)
  • Cefepime monotherapy for treatment of febrile neutropenia, SIOP-Asia Congress, 2006-04-04 to 2006-04-07, International Society of Pediatric Oncology (SIOP), (International)
ORAL
  • Safety and Efficacy of Carbapenems in Children, 26th Annual Congress of the Malaysian Paediatric Association, 2004-09-02 to 2004-09-04, Malaysian Paediatric Association, (National)
  • Screening for oncogene fusion transcripts in childhood acute lymphoblastic leukemia using multiplex RT-PCR, 37th Congress of International Society of Paediatric Oncology (SIOP). Geneva, 20 24 Sep 2006, 2006-09-20 to 2006-09-24, International Society of Paediatric Oncology (SIOP), (International)

EVALUATION ACTIVITIES
(Description), (Evaluation Activity),(Year).


  • Medical Pediatric Oncology ,  ( )
  • Pediatric Hematology Oncology ,  ( )
  • Pediatric Blood and Cancer ,  ( )
  • Journal of Pediatric Hematology/Oncology ,  ( )

CONTRIBUTION TO SOCIETY
(Contribution To Society), (Level), (Start Date), (End Date).


  • Member; Subspeciality Credentialling Subcommittee for paediatric haematology-oncology, (National), 01/01/2014 until 31/12/2016
  • President, Malaysian Society of Paediatric Oncology, (Country), 07/07/2011 until 31/07/2012

SUPERVISION


POST GRADUATE STUDENT
(Name of Degree), (Name of Candidates), (Title of Thesis), (Academic Session)

Ongoing
  • Master Degree, Nin Bun San, -
  • Doctoral Degree (phd), Chua Ling Ling, Association Between Gut Microbiome Dysbiosis With Systemic Immune Activation, Inflammation and Pre-Mature Age-Related Comorbidities, 2018/2019
  • Master Degree, Chin Tong Foh, CYTOGENETIC RISK STRATIFICATION OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA USING KARYOTYPING AND FLUORESCENT IN-SIFU HYBRIDIZATION (FISH), 2018/2019
  • Doctoral Degree (phd), Oh Lixian, Role of p53 N-Terminal Isoforms in Development of Childhood Embryonal Cancers., 2017/2018
  • Doctoral Degree (phd), Mohamad Shafiq Azanan, Late Effects in Childhood Leukemia Survivors: Relationship of Immune Dysregulation and Cytomegalovirus Infection with Cardiometabolic Risk Factors and Endothelial Dysfunction, 2017/2018
  • Master Degree, Kavimalar Renganathan, RB1 gene mutation in Malaysian Children with Retinoblastoma, 2013/2014
  • Master Degree, Chen Kok Siong, Karyotyping of childhood and adult leukaemia, 2012/2013
  • Doctoral Degree (phd), Hayan Tariq Madhloom, Image Processing Applications for the Localization and Segmentation of Blast Cells Using Peripheral Blood Images, 2012/2013
  • Master Degree, Choong Soo Sin, Li-Fraumeni Syndrome in Malaysian Families, 2011/2012
  • Master Degree, Anis Siham, Childhood rhabdomyosarcoma, 2007/2008
  • Master Degree, Kamariah Ibrahim, Molecular quantitative chimerism analysis on post-transplantation haematopoeitic stem cells using insertion-deletion polymorphic markers, 2007/2008
  • Master Degree, Siti Sarah Daud, WT-1 as a marker of minimal residual disease in childhood acute myeloid leukemia, 2007/2008
  • Master Degree, Chong Sze Yee, Depth of needle during lumbar puncture in children, 2004/2005

Completed
  • Master Degree, Lim Huay Ling, -
  • Master Degree, Lum Su Han, GATA1 mutations in abnormal myelopoeisis in children with Down Syndrome, 2011/2012
  • Master Degree, Shanti Ramachandran, Clinical features and biological factors in neuroblastoma, 2005/2006
  • Master Degree, Lim Huay Ling, Role of Full Blood Count in detecting relapse in children with acute lymphoblastic leukemia, 2004/2005
FIRST DEGREE/DIPLOMA/PRE-DEGREE
(Course Title), (Academic Session), (No. of Candidates)

Completed
  • Evaluation of engraftment status following HSCT using multiplex PCR amplification of selected short tandem repeats, 2005/2006, 1
  • Screening for oncogene fusion transcripts in acute lymphoblastic leukemia using multiplex RT-PCR assay, 2005/2006, 1
  • Efficacy of chemotherapeutic drugs against primary and relapsed childhood leukemic cells, 2002/2003, 1
  • In vitro assessment of the efficacy of standard chemotherapeutic drugs used in childhood leukemia, 2000/2001, 1

TEACHING
(Course Title), (Academic Session), (No of Student), (No of Contact Hours).


POST GRADUATE
  • Clinical Oncology, 2011/2012(2), 10, 2
  • Master of paediatrics, 2007/2008, 30, 120
  • Post-basic nursing degree (Oncology), 2007/2008(1), 50, 67
FIRST DEGREE
  • MBBS (Phase 2), 2007/2008, 160, 19
  • MBBS (Phase 3B), 2007/2008, 160, 135
  • MBBS (Phase3A), 2007/2008, 40, 90