Curriculum Vitae

DR. MUHAMMAD FARID NAZER BIN MUHAMMAD FARUQU

Senior Lecturer
  • Department of Pharmacology
    Faculty of Medicine

AREAS OF EXPERTISE

  • BIOMARKER DISCOVERY
    Exosome / Extracellular Vesicle-based Biomarker Discovery
  • VACCINE DEVELOPMENT
    Exosome / Extracellular Vesicle-based Vaccines
  • NANOBIOLOGICS
    Exosome / Extracellular Vesicle-based Nanobiologics
  • THERAPEUTICS
    Cancer Nanomedicine

ACADEMIC QUALIFICATION

  • PHD (PHARMACEUTICAL SCIENCE), (Pharmaceutical Science)
    King's College, London
  • MSC (BIOCHEMISTRY), (Biochemistry)
    Cambridge University, United Kingdom

ADMINISTRATIVE DUTIES

  • Coordinator
    15 Nov 2022 - 31 Dec 2024 (Dean Office, Faculty of Medicine)
  • Coordinator
    01 Jan 2023 - 31 Dec 2024 (Dean Office, Faculty of Medicine)
  • Committee Members
    01 Jan 2023 - 31 Dec 2023 (Dean Office, Faculty of Medicine)
  • Committee Members
    01 Jan 2023 - 31 Dec 2023 (Dean Office, Faculty of Medicine)
  • Coordinator
    15 Oct 2021 - 30 Sep 2023 (Department)

MEMBERSHIPS

  • CONTROLLED RELEASE SOCIETY - MALAYSIA LOCAL CHAPTER (MYCRS), MEMBER
    2023 to 2024 (National)
  • TISSUE ENGINEERING AND REGENERATIVE MEDICINE SOCIETY OF MALAYSIA (TESMA), MEMBER
    2022 to 2022 (National)
  • CONTROLLED RELEASE SOCIETY - MALAYSIA LOCAL CHAPTER (MYCRS), MEMBER
    2021 to 2022 (National)
  • CONTROLLED RELEASE SOCIETY - MALAYSIA LOCAL CHAPTER, MEMBER
    2021 to 2022 (National)
  • INTERNATIONAL SOCIETY FOR EXTRACELLULAR VESICLES (ISEV), MEMBER
    2019 to 2021 (International)
  • CONTROLLED RELEASE SOCIETY (CRS), MEMBER
    2019 to 2020 (International)

AWARD AND STEWARDSHIP

  • MAKNA Cancer Research Awards
    Majlis Kanser Nasional (MAKNA), 2021 (National)

PUBLICATIONS

Article in Journal
WoS
  1. Azizan, Suha; Cheng, Kim Jun; Mohamed, Elsa Haniffah Mejia; Ibrahim, Kamariah; Faruqu, Farid Nazer; Vellasamy, Kumutha Malar; Khong, Tak Loon; Syafruddin, Saiful Effendi; Ibrahim, Zaridatul Aini (2024). Insights into the molecular mechanisms and signalling pathways of epithelial to mesenchymal transition (EMT) in colorectal cancer: A systematic review and bioinformatic analysis of gene expression, GENE. 896. doi:10.1016/j.gene.2023.148057
  2. Liam-Or, Revadee; Faruqu, Farid N.; Walters, Adam; Han, Shunping; Xu, Lizhou; Wang, Julie Tzu-Wen; Oberlaender, Jennifer; Sanchez-Fueyo, Alberto; Lombardi, Giovanna; Dazzi, Francesco; Mailaender, Volker; Al-Jamal, Khuloud T. (2024). Cellular uptake and in vivo distribution of mesenchymal-stem-cell-derived extracellular vesicles are protein corona dependent, NATURE NANOTECHNOLOGY. . doi:10.1038/s41565-023-01585-y
  3. Loke, Yean Leng; Beishenaliev, Adilet; Wang, Pei-Wen; Lin, Chung-Yin; Chang, Chia -Yu; Foo, Yiing Yee; Faruqu, Farid Nazer; Leo, Bey Fen; Misran, Misni; Chung, Lip Yong; Shieh, Dar-Bin; Kiew, Lik Voon; Chang, Chia-Ching; Teo, Yin Yin (2023). ROS-generating alginate-coated gold nanorods as biocompatible nanosonosensitisers for effective sonodynamic therapy of cancer, ULTRASONICS SONOCHEMISTRY. 96. doi:10.1016/j.ultsonch.2023.106437
  4. Khan, Azalea A.; Man, Francis; Faruqu, Farid N.; Kim, Jana; Al-Salemee, Fahad; Carrascal-Minino, Amaia; Volpe, Alessia; Liam-Or, Revadee; Simpson, Paul; Fruhwirth, Gilbert O.; Al-Jamal, Khuloud T.; de Rosales, Rafael T. M. (2022). PET Imaging of Small Extracellular Vesicles via [Zr-89]Zr(oxinate)(4) Direct Radiolabeling, BIOCONJUGATE CHEMISTRY. 33(3), 473-485. doi:10.1021/acs.bioconjchem.1c00597
  5. Beishenaliev, A., Faruqu, F. N., Leo, B. F., Lit, L. C., Loke, Y. L., Chang, C. C., . . . Kiew, L. V. (2021). Facile synthesis of biocompatible sub-5 nm alginate-stabilised gold nanoparticles with sonosensitising properties. Colloids and Surfaces a-Physicochemical and Engineering Aspects, 627, 10. doi: 10.1016/j.colsurfa.2021.127141
  6. Faruqu, Farid N.; Liam-Or, Revadee; Zhou, Shuai; Nip, Rebecca; Al-Jamal, Khuloud T. (2021). Defined serum-free three-dimensional culture of umbilical cord-derived mesenchymal stem cells yields exosomes that promote fibroblast proliferation and migration in vitro, FASEB JOURNAL. 35(1). doi:10.1096/fj.202001768RR
  7. Giram, Prabhanjan S.; Wang, Julie Tzu-Wen; Walters, Adam A.; Rade, Priyanka P.; Akhtar, Muhammad; Han, Shunping; Faruqu, Farid N.; Abdel-Bar, Hend M.; Garnaik, Baijayantimala; Al-Jamal, Khuloud T. (2021). Green synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo, BIOMATERIALS SCIENCE. 9(3), 795-806. doi:10.1039/d0bm01421d
  8. Lazaro-Ibanez, Elisa; Faruqu, Farid N.; Saleh, Amer F.; Silva, Andreia M.; Wang, Julie Tzu-Wen; Rak, Janusz; Al-Jamal, Khuloud T.; Dekker, Niek (2021). Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo, ACS NANO. 15(2), 3212-3227. doi:10.1021/acsnano.0c09873
  9. Xu, Lizhou; Faruqu, Farid N.; Lim, Yau M.; Lim, Kee Y.; Liam-Or, Revadee; Walters, Adam A.; Lavender, Paul; Fear, David; Wells, Claire M.; Wang, Julie Tzu-Wen; Al-Jamal, Khuloud T. (2021). Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment, BIOMATERIALS. 264. doi:10.1016/j.biomaterials.2020.120369
  10. Managuli, Renuka S.; Wang, Julie Tzu-Wen; Faruqu, Farid Muhammad; Pandey, Abhjieet; Jain, Sanyog; Al-Jamal, Khuloud T.; Mutalik, Srinivas (2020). Surface engineered nanoliposomal platform for selective lymphatic uptake of asenapine maleate: In vitro and in vivo studies, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 109. doi:10.1016/j.msec.2019.110620
  11. Taylor, Peter J.; Hagen, Jana; Faruqu, Farid N.; Al-Jamal, Khuloud T.; Quigley, Bonnie; Beeby, Morgan; Selkirk, Murray E.; Sarkies, Peter (2020). Trichinella spiralis secretes abundant unencapsulated small RNAs with potential effects on host gene expression, INTERNATIONAL JOURNAL FOR PARASITOLOGY. 50(9), 697-705. doi:10.1016/j.ijpara.2020.05.008
  12. Tung, Sim Lai; Fanelli, Giorgia; Matthews, Robert Ian; Bazoer, Jordan; Letizia, Marilena; Vizcay-Barrena, Gema; Faruqu, Farid N.; Philippeos, Christina; Hannen, Rosalind; Al-Jamal, Khuloud T.; Lombardi, Giovanna; Smyth, Lesley Ann (2020). Regulatory T Cell Extracellular Vesicles Modify T-Effector Cell Cytokine Production and Protect Against Human Skin Allograft Damage, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 8. doi:10.3389/fcell.2020.00317
  13. Xu, Lizhou; Faruqu, Farid N.; Liam-or, Revadee; Abu Abed, Omar; Li, Danyang; Venner, Kerrie; Errington, Rachel J.; Summers, Huw; Wang, Julie Tzu-Wen; Al-Jamal, Khuloud T. (2020). Design of experiment (DoE)-driven in vitro and in vivo uptake studies of exosomes for pancreatic cancer delivery enabled by copper-free click chemistry-based labelling, JOURNAL OF EXTRACELLULAR VESICLES. 9(1). doi:10.1080/20013078.2020.1779458
  14. Faruqu, Farid N.; Wang, Julie Tzu-Wen; Xu, Lizhou; McNickle, Luke; Chong, Eden Ming-Yiu; Walters, Adam; Gurney, Mark; Clayton, Aled; Smyth, Lesley A.; Hider, Robert; Sosabowski, Jane; Al-Jamal, Khuloud T. (2019). Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach, THERANOSTICS. 9(6), 1666-1682. doi:10.7150/thno.27891
  15. Managuli, Renuka S.; Wang, Julie T.; Faruqu, Farid N.; Kushwah, Varun; Rauti, Sushil Y.; Shreya, Ajjappla B.; Al-Jamal, Khuloud T.; Jain, Sanyog; Mutalik, Srinivas (2019). Asenapine maleate-loaded nanostructured lipid carriers: optimization and in vitro, ex vivo and in vivo evaluations, NANOMEDICINE. 14(7), 889-910. doi:10.2217/nnm-2018-0289
  16. Sunoqrot, Suhair; Al-Debsi, Tahany; Al-Shalabi, Eveen; Ibrahim, Lina Hasan; Faruqu, Farid Nazer; Walters, Adam; Palgrave, Robert; Al-Jamal, Khuloud T. (2019). Bioinspired Polymerization of Quercetin to Produce a Curcumin-Loaded Nanomedicine with Potent Cytotoxicity and Cancer-Targeting Potential in Vivo, ACS BIOMATERIALS SCIENCE & ENGINEERING. 5(11), 6036-6045. doi:10.1021/acsbiomaterials.9b01240
  17. Faruqu, Farid N.; Xu, Lizhou; Al-Jamal, Khuloud T. (2018). Preparation of Exosomes for siRNA Delivery to Cancer Cells, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. (142). doi:10.3791/58814
  18. Suffian, Izzat F. M.; Wang, Julie T. -W.; Faruqu, Farid N.; Benitez, Julio; Nishimura, Yuya; Ogino, Chiaki; Kondo, Akihiko; Al-Jamal, Khuloud T. (2018). Engineering Human Epidermal Growth Receptor 2-Targeting Hepatitis B Virus Core Nanoparticles for siRNA Delivery in Vitro and in Vivo, ACS APPLIED NANO MATERIALS. 1(7), 3269-3282. doi:10.1021/acsanm.8b00480
ESCI
  1. Faruqu, Farid N.; Zhou, Shuai; Sami, Noor; Gheidari, Fatemeh; Lu, Han; Al-Jamal, Khuloud T. (2020). Three-dimensional culture of dental pulp pluripotent-like stem cells (DPPSCs) enhances Nanog expression and provides a serum-free condition for exosome isolation, FASEB BIOADVANCES. 2(7), 419-433. doi:10.1096/fba.2020-00025

RESEARCH PROJECT

National
  1. 2023 - 2026, Fundamental Research Grant Scheme (FRGS)
    Elucidating The Role And Mechanism Of The Hif-1? On Tgf?/alks/smads Axis In Human Fibroblast Like Synoviocyte To Combat Osteoarthritis Induced Synovial Fibrosis ( Co-Researcher)
  2. 2022 - 2025, Fundamental Research Grant Scheme (FRGS)
    Evaluating Directed Encapsulation Of CRISPR/Cas9 As Self-Assembled Ribonucleoprotein (RNP) Complex Into Exosomes For CD73 Ablation As Locally Administered Lung Cancer Immunotherapy ( Principal Investigator(PI))
  3. 2023 - 2025, Others MOHE
    Exosome-based Vaccine Against Viral Antigens ( Co-Researcher)
  4. 2023 - 2025, University Grant
    Investigating Bioengineered Exosomes Containing CRISPR/Cas9 for Anx-A1 Silencing as a Novel Strategy for Combatting Chemoresistance in CRC ( Co-Researcher)
  5. 2020 - 2024, Fundamental Research Grant Scheme (FRGS)
    Elucidation Of The Effects Of Cigarette, Electronic Cigarette And Dual-use On Cellular Morphology, Biochemical And Genetic Profile Alterations Of Smokers ( Co-Researcher)
  6. 2022 - 2024, Others MOHE - Top 100 (IIRG)-FNW
    Elucidation Of Surface Proteins From Plasma-derived Exosomes As Novel Candidate Biomarkers For Lung Cancer Early Detection ( Co-Researcher)
  7. 2022 - 2024, UM International Collaboration Grant
    The Development of ultrasound-responsive multistage-ultrasmall nanoparticles for improved tumour penetration and renal clearance ( Co-Researcher)
  8. 2022 - 2024, Fundamental Research Grant Scheme (FRGS)
    Understanding the physicochemical properties and cellular mechanisms of immunomodulator drug in exosomes for cutaneous manifestations triggered by exaggerated cytokine production, National University of Malaysia (UKM) ( Co-Researcher)
Private
  1. 2022 - 2023, Private Funding
    Exosome-mediated Delivery Of Endogenously Loaded Crispr/ Cas9 Ribonucleoprotein (rnp) Complex Targeting Cd73 For Triple Negative Breast Cancer (tnbc) Immunotheraphy ( Principal Investigator(PI))
  2. 2022 - 2023, Private Funding
    Exosome-mediated Delivery Of Endogenously Loaded Crispr/cas9 Ribonucleoprotein (rnp) Complex For Lung Cancer Immunotherapy ( Principal Investigator(PI))

PAPER PRESENTED

INVITED SPEAKER
  1. Exploring Exosomes as Next-Generation Nanobiologics, Joint Symposium in Frontiers in Biomedical Sciences and Technologies, Faculty of Medicine (FOM) Universiti Malaya & Hong Kong City University (International) (02 Mar 2023 - 02 Mar 2023)
  2. MTSF Science & Technology Grant Sharing session, MTSF Science & Technology Grant Sharing session, PPGP, UM (University) (18 Feb 2022 - 18 Feb 2022)
  3. Exosomes: Emerging "Star" in Nanomedicine, Breakfast@UMHealth , UMHealth (University) (22 Sep 2021 - 22 Sep 2021)
  4. Exosomes: Nanomedicine's new "influencer", MyCRS Virtual Seminar Series 3/21 & AGM , Controlled Release Society - Malaysia Chapter (MyCRS) (National) (17 Aug 2021 - 17 Aug 2021)
  5. Membrane radiolabelling of exosomes for comparative biodistribution analysis in immunocompetent and immunodeficient mice, EV Imaging Workshop , International Society for Extracellular Vesicles (ISEV)  (International) (19 Mar 2020 - 19 Mar 2020)
ORAL PRESENTER
  1. Three-dimensional culture of dental pulp pluripotent-like stem cells (DPPSC) enhances Nanog expression and provides a serum-free condition for exosome isolation, Controlled Release Society (CRS) Annual Meeting & Exposition, Controlled Release Society (International) (21 Jul 2019 - 21 Jul 2019)
  2. Membrane radiolabelling of exosomes for comparative biodistribution analysis in immunocompetent and immunodeficient mice, UK Extracellular Vesicles (UKEV) Forum, International Society for Extracellular Vesicles (ISEV) (National) (12 Dec 2017 - 12 Dec 2017)
POSTER PRESENTER
  1. In vivo tracking of extracellular vesicles: comparison across nuclear, optical and luminescence approaches, 12th European and Global Clinical Nanomedicine (CLINAM) Summit, European Foundation for Clinical Nanomedicine (International) (02 May 2020 - 04 May 2020)
  2. Three-dimensional culture of dental pulp pluripotent-like stem cells (DPPSC) enhances Nanog expression and provides a serum-free condition for exosome isolation, International Society for Extracellular Vesicles (ISEV) Annual Meeting , International Society for Extracellular Vesicles (ISEV) (International) (24 Apr 2019 - 28 Apr 2019)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2023) Fast Track Phd Confirmation Defence (Geo Hui Nee), University, (Internal Examiner)
  2. (2023) Fast Track Phd Proposal Defence (Soh Li Jen), University, (Reviewer)
  3. (2023) Masters (Mixed Mode) Porposal Defence (Anand R. Chandrasekaran), University, (Reviewer)
  4. (2023) Phd Proposal Defence (Wan Muhammad Farhan), University, (Reviewer)
  5. (2023) Masters Proposal Defence (Chen Jzit Weii), University, (Reviewer)
  6. (2023) Fast Track Phd Proposal Defence (Lim Xin Yun), University, (Reviewer)
  7. (2022) Phd Confirmation Defence (Departmental), University, (Internal Assessor)
  8. (2022) Frgs2022 Internal Reviewer (Faculty Level), University, (Reviewer)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2023) INVESTIGATING THE ROLE OF MIRNA AND EXOSOMES IN MODULATING CYTOSKELETON AND ECM CHANGES IN PSORIATIC SKIN, LI, SIJING
  2. (2023) DEVELOPMENT OF A NOVEL EXOSOME-BASED DENGUE VACCINE FOR INDUCING PROTECTIVE IMMUNITY AGAINST ALL FOUR DENGUE VIRUS SEROTYPES, CHEAH ZIYIN
  3. (2023) BIOINORGANIC SYNTHESIS OF POLYTHIOPHENE STABILIZED Fe3O4@GRAPHENE OXIDE IN PHOTOTHERMAL-CHEMOTHERAPY TREATMENT FOR CERVICAL CANCER, Hiba Huzyan
  4. (2022) Antibiotic-Loaded Exosomes Hydrogel against Multidrug-Resistant Staphylococcus aureus for the Treatment of Bacterial Infection in Wounds, Melissa June Paderog (National University of Malaysia (UKM))
Master
  1. (2023) DEVELOPMENT OF EXOSOME-BASED PEPTIDE VACCINE (E3P-EXO) FOR DENGUE VIRUS INFECTION, HARIZ BIN MOHAMAD SALLEH
  2. (2023) EXOSOME-MEDIATED DELIVERY OF ENDOGENOUSLY LOADED CRISPR/CAS9 RIBONUCLEOPROTEIN (RNP) COMPLEX TARGETING CD73 FOR LUNG CANCER IMMUNOTHERAPY, ZHER PIN GOH
  3. (2023) ELUCIDATION OF SURFACE PROTEINS FROM PLASMA-DERIVED EXOSOMES AS NOVEL BIOMARKERS FOR LUNG CANCER EARLY DETECTION, SAFIAH SAKINAH BINTI RAMLI @ MD SHAH
Under Graduate Students
  1. (2023) Preliminary investigation on the induction of immunogenic cell death (ICD) in cancer cells in vitro by ultrasmall gold nanoparticles (usGNP) via sonodynamic therapy (SDT)
  2. (2023) Investigating the activity of CRISPR/Cas9 ribonucleoprotein complex (RNP) as a ternary fusion with a fluorescent and exosomal protein and its directed encapsulation into exosomes

TEACHING

Bachelor
  1. (2023) UMMP - Universiti Malaya Medical Programme
  2. (2023) MIC3010 - Advances in Medical Pharmacology
  3. (2023) MIC2021 - Biomedical Ethics
  4. (2023) MIX3003 - Drugs: from Target to Market
  5. (2023) MIC3009 - Ethical Practices in Biomedical Science
  6. (2023) DIA2006 - Pharmacology
  7. (2023) MID1009 - Pharmacology in Nursing
  8. (2023) MIC2004 - Principles in Pharmacology and Toxicology
  9. (2022) UMMP - Universiti Malaya Medical Programme
  10. (2022) MIC3010 - Advances in Medical Pharmacology
  11. (2022) MIX3003 - Drugs from Target to Market
  12. (2022) DIA2006 - Pharmacology
  13. (2022) MIC2004 - Principles in Pharmacology and Toxicology
  14. (2021) DIA2006 - Pharmacology
  15. (2021) UMMP - Ummp Stage 1,2 and 3.3
  16. (2020) UMMP - Ummp Stage 1,2 and 3.3

SOCIAL RESPONSIBILITY ACTIVITIES

  • Invited Speaker for Divine Insight - Talk by Harmoni UM, (05 Dec 2023 - 12 Dec 2023) (University)
  • Invited Speaker for Kyuem Alumni Weekend Sharing Forum 2023, (17 Jun 2023 - 17 Jun 2023) (National)
  • Seminar Ibu Bapa Memastikan Peningkatkan Akademik Anak (Impak) - Speaker and Organising Committee, (19 Jun 2022 - 19 Jun 2022) (National)
  • Invited Speaker for Quranic Moments Series by Harmoni UM, (31 Dec 2021 - 31 Dec 2021) (University)