Curriculum Vitae

DR. PHANG KEAN CHANG

Senior Lecturer
  • Department of Pathology
    Faculty of Medicine
  • 0379493209

BIOGRAPHY


Dr. Phang is an experienced clinical scientist with a strong academic background and a breadth of expertise in various fields. He holds a Ph.D. in Pathology and has pursued dual master's degrees in Health Research Ethics, in collaboration with Johns Hopkins University, and Medical Sciences (Pathology). Additionally, he obtained a bachelor's degree in Biohealth Science. Currently, he serves as a Senior Lecturer in the Department of Pathology at Universiti Malaya and holds the position of Secretary (Manager) at the University of Malaya Medical Centre-Medical Research Ethics Committee.

Dr. Phang's research endeavors primarily revolve around precision medicine, encompassing molecular testing for cancer diagnosis, digital pathology, cancer and cell therapy, as well as the exploration of novel biomarkers for diagnostic purposes. In the realm of research ethics, he has acquired extensive training and fellowships under renowned institutions such as the World Health Organization, Department of Bioethics, NIH United States, and WCG IRB-New York University Langone Health. His passion lies in investigating ethical issues related to emerging technologies and epidemic ethics, alongside the pursuit of enhancing the quality of Institutional Review Boards (IRBs) to ensure the protection of human subjects in health research.

In recognition of his contributions to the scientific community, Dr. Phang has been appointed as an affiliate member of the Academy Sciences of Malaysia (YSN-ASM) since 2020. Moreover, his outstanding achievements led to an honorary appointment as a Chartered Scientist of the UK Royal College of Biology in 2023.

AREAS OF EXPERTISE


  • PATHOLOGY
  • BIOMEDICINE
  • BIOETHICS

ACADEMIC QUALIFICATION


  • MOHRE (UM) (2020), (Health Research Ethics)
    Universiti Malaya (UM)
  • Ph.D (PATHOLOGY) (UKM) (2018), (Pathology)
    Universiti Kebangsaan Malaysia (UKM)
  • BSc.(HONS) (UM) (2008), (Biohealth Science)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES


  • Committee Members
    22 Nov 2022 - 31 Dec 2024 (Dean Office, Faculty of Medicine)
  • Coordinator
    01 Sep 2022 - 31 Aug 2024 (Department)
  • Document Controller
    01 Sep 2022 - 30 Aug 2024 (Department)
  • Medical Research Ethics Unit
    09 Aug 2023 - 11 Aug 2024 (University Malaya)
  • Manager
    03 Feb 2020 - 07 Feb 2024 (Dean Office, Faculty of Medicine)
  • Manager
    07 Feb 2020 - 04 Feb 2024 (University Malaya)

MEMBERSHIPS


  • SECRETARY (MANAGER), SECRETARY
    2023 to present (University)
  • CHARTERED SCIENTIST, MEMBER
    Since 2023 (International)
  • LIFETIME MEMBER - MALAYSIAN SOCIETY OF HAEMATOLOGY, MEMBER
    Since 2022 (National)
  • ASM HEALTH COMMITTEE MEMBER, MEMBER
    2022 to 2024 (National)
  • SECRETARY OF UMMC-MEDICAL RESEARCH ETHICS COMMITTEE, SECRETARY
    2022 to 2024 (University)
  • LIFETIME MEMBER OF FORUM FOR ETHICAL REVIEW COMMITTEES IN ASIA AND THE WESTERN PACIFIC (FERCAP), MEMBER
    Since 2019 (International)
  • FERCAP LIFETIME MEMBER (FORUM FOR ETHICAL REVIEW COMMITTEES IN ASIA AND THE WESTERN PACIFIC), MEMBER
    Since 2019 (International)
  • MEMBER (INTERNATIONAL CLINICAL SCIENTIST) - ASCP, MEMBER
    2023 to 2023 (International)
  • AFFILIATESHIP , MEMBER
    2021 to 2023 (National)
  • AMERICAN SOCIETY FOR CLINICAL PATHOLOGY, MEMBER
    2022 to 2023 (International)
  • AMERICAN SOCIETY FOR CLINICAL PATHOLOGY, MEMBER
    2022 to 2022 (International)

AWARD AND STEWARDSHIP


  • WCG-IRB International Fellowship in collaboration with New York University
    WCG-IRB, 2022 (International)

PUBLICATIONS


Article in Journal
WoS
  1. Voo, Teck Chuan; Ballantyne, Angela; Ng, Chirk Jenn; Cowling, Benjamin J.; Xiao, Jingyi; Phang, Kean Chang; Kaur, Sharon; Jenarun, Grazele; Kumar, Vishakha; Lim, Jane Mingjie; Tun, Zaw Myo; Wong, Nigel Chong Boon; Tam, Clarence C. (2022). Public acceptability of COVID-19 control measures in Singapore, Hong Kong, and Malaysia: A cross-sectional survey, INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 120, 51-58. doi:10.1016/j.ijid.2022.04.021
  2. Masir, Noraidah; Akhter, Ariz; Roshan, Tariq M.; Florence, Chandramaya Sabrina; Abdul-Rahman, Faridah; Tumian, Nor Rafeah; Kean-Chang, Phang; Elyamany, Ghaleb; Shabani-Rad, Meer-Taher; Mansoor, Adnan (2019). Diffuse large B-cell lymphoma in Southeast Asian cohort: expression patterns of B-cell receptor (BCR) repertoire and its linkage with molecular subtypes and response to R-CHOP therapy, JOURNAL OF CLINICAL PATHOLOGY. 72(9), 630-635. doi:10.1136/jclinpath-2019-205837
  3. Phang, Kean Chang; Hussin, Noor Hamidah; Rahman, Faridah Abdul; Tizen, Nur Maya Sabrina; Mansoor, Adnan; Masir, Noraidah (2019). Characterisation of immunogenotypes of diffuse large B-cell lymphoma, MALAYSIAN JOURNAL OF PATHOLOGY. 41(2), 101-124
Others
  1. Phang, K. C., Akhter, A., Tizen, N., Rahman, F. A., Zahratul Azma, R., Elyamany, G., Shabani-Rad, M. T., Masir, N., & Mansoor, A. (2018). Comparison of protein-based cell-of-origin classification to the Lymph2Cx RNA assay in a cohort of diffuse large B-cell lymphomas in Malaysia. Journal of clinical pathology, 71(3), 215 220. https://doi.org/10.1136/jclinpath-2017-204548
  2. Akhter, A., Masir, N., Elyamany, G., Phang, K. C., Mahe, E., Al-Zahrani, A. M., Shabani-Rad, M. T., Stewart, D. A., & Mansoor, A. (2015). Differential expression of Toll-like receptor (TLR) and B cell receptor (BCR) signaling molecules in primary diffuse large B-cell lymphoma of the central nervous system. Journal of neuro-oncology, 121(2), 289 296. https://doi.org/10.1007/s11060-014-1655-3
Other Publications
  1. Olaybal, M. A. M., Chang, P. K., Abdullah, A., Wong, D., Yee, L. K., Wei, L. K., . . . Zakaria, Z. H. (2023). Malaysia Decentralised Clinical Trial (DCT) Guidance Document. Clinical Research Malaysia. - Policy Paper
  2. Tan, L-H., Phang, K-C., Novakovic, D. (2020), Strategic Communication for Salt Reduction To Strengthen Salt Reduction Action in Malaysia, World Health Organization Country Office for Malaysia, Brunei Darussalam and Singapore - Policy Paper

RESEARCH INTEREST


  • Digital pathology (Digital pathology)
  • Artificial Intelligence in medicine (Ai in medicine)
  • Creative arts in medicine (Arts in medicine)
  • Cancer & cell therapy (Cell therapy)
  • Biomarkers for diagnosis (Biomarkers)
  • Rapid diagnostic testings (Rapid testings)
  • Epidemic ethics (Pandemic)
  • Ethics in emerging technologies (Ethics in science)
  • Protection of human subjects in health research (Protection human subjects, IRB)
  • Sports & healthy lifestyle (Sports exercise)

RESEARCH PROJECT


National
  1. 2023 - 2026, Fundamental Research Grant Scheme (FRGS)
    Elucidating The Molecular Mechanisms Of Exosomal Circltbp2-mediated Temozolomide Resistance In Glioblastoma Via C-met/stat3 Pathway And Mgmt Acetylation ( Co-Researcher)
  2. 2020 - 2021, Covid-19 Special Research Grant
    Physical Activity Levels, Motivation, Knowledge And Challenges During Lockdown Or Movement Control Amid Covid-19 Outbreak Among Malaysian Adults ( Co-Researcher)
Private
  1. 2023 - 2024, Private Funding
    Clinicopathological Characteristics And Survival Of Ebv Positive Diffuse Large B-cell Lymphoma Not Otherwise Specified: A Single- Centred Study In Malaysia ( Principal Investigator(PI))
  2. 2022 - 2024, Stadpharm
    A PHASE IB/II SINGLE ARM, OPEN LABEL TRIAL TO ASSESS THE EFFICACY AND SAFETY OF CHIMERIC ANTIGEN RRECEPTOR (CAR)-T CELL THERAPY TARGETING THE CD19 ANTIGEN (AUXICART-19) FOR PATIENTS WITH RELAPSED OR REFRACTORY AGGRESSIVE B-CELL LYMPHOMA IN MALAYSIA, University of Malaya ( Co-Researcher)
International
  1. 2023 - 2028, International Funding
    The Global Health Bioethics Network ( Co-Researcher)

CONSULTANCY PROJECT


  • Review of Covid-19 Laboratory Capacity and Testing Strategies in Malaysia, Brunei Darussalam, and Singapore; Applying The Principles of Public Health Ethics in The Implementation of Testing Strategies., World Health Organization, Consultant
    12 Jul 2020 - 14 Sep 2020 (International)
  • Communication-Based Regulation: An Intervention Strategy for Unproven Stem Cell Therapy in Malaysia (Gpf002m-2018), DR MOHAMMAD FIRDAUS BIN ABDUL AZIZ, Professional Consultant (Ir., Ar., Sr., Ts., dsbnya)
    15 Jun 2020 - 16 Aug 2020 (University)

PAPER PRESENTED


ORAL PRESENTER
  1. Implementation of health research ethics practicum programme: experiences from a Malaysian research ethics committee, 2022 FERCAP International Conference, SIDCER-FERCAP (International) (28 Nov 2022 - 29 Dec 2022)
  2. CD5 expression in diffuse large B-cell lymphoma amongst Malaysian patients., 2014 International Congress of Pathology & Laboratory Medicine (ICPaLM), ICPALM (International) (07 Mar 2014 - 10 Mar 2014)
  3. Noraidah Masir. Gene rearrangements studies in diffuse large B-cell lymphoma of Malaysian population, International Conference on Advances in Medical Sciences (ICAMS) 2013, ICAMS (International) (14 Aug 2013 - 16 Aug 2013)
  4. Gene rearrangement in diffuse large B-cell lymphoma: the correlation with clinicopathological features, Minggu Penyelidikan dan Perubatan ke-14, PPUKM, PPUKM (University) (16 Jul 2012 - 20 Jul 2012)

ACADEMIC/PROF. SERVICES


Evaluation
  1. (2023) Investigating The Effect of Secretome Derived from Adsc Preconditioned With Ruxadustat On Nucleolus Pulposus Cell Proliferation, and Chondrogenic Gene Expression, University, (Internal Examiner)
  2. (2023) Research Proposal Defense (Joanna Priya Gerard, Student No. 22078001) Master of Medical Science Programme, University, (Reviewer)
  3. (2023) Examiner for The Mqf7001: Health Research Methods, University, (Internal Examiner)
  4. (2022) Interviewer for MBBS Intake 2022/2023, University, (Internal Assessor)
  5. (2022) Examiner for Mqf7002: Research Project, Master of Health Research Ethics, University, (Internal Examiner)
Contribution to external organisation
  1. (2022) Facilitator, International, (Expert Advisor)
  2. (2021) Wcg Irb International Fellows Program, International, (Research Fellow/Associate)
Contribution to event
  1. (2023) Scientific Chair, International, (Event Organiser)
  2. (2022) Ethical Issues in Clinical Trial - Overview of Ethical Issues, Role of Irb/Iec, University, (Course Facilitator)
Media appearance
  1. (2021) Speaker for Research Ethics On Bfm Radio, National, (Interview)

SUPERVISION


Postgraduate Student
PhD/ Doctoral
  1. (2023) EXOSOMAL CIRCLTBP2 REGULATES MGMT THROUGH ACETYLATION OF C-MET/STAT3 PATHWAY TO PROMOTE TEMOZOLOMIDE RESISTANCE MECHANISM IN GLIOBLASTOMA, LI QIANG
  2. (2023) UNRAVELING THE DIAGNOSTIC AND THERAPEUTIC POTENTIAL OF CELL-FREE EXTRACHROMOSOMAL CIRCULAR DNA IN DIFFUSE LARGE B CELL LYMPHOMA: A NOVEL APPROACH, QU RUOKAI
Master
  1. (2023) Genomic Sequencing and Bioinformatics Analyses to Elucidate Metastatic Related Genes in Human Metastatic Nasopharyngeal Carcinoma, LOO EE MIN (Ucsi University)
  2. (2022) Exploring Ethical Challenges Encountered by IRBs During COVID-19: A Narrative Review, LESEGO ODUETSE
  3. (2022) Review on Ethical Guideline of Protocol Deviation in Health Resarch, SITI NAJIHAH BINTI SAIDIN
  4. (2021) The Moral Voice of Ethics Review Boards: A Practice in Search of Theory, LEANDER MARQUEZ
  5. (2020) Defining Vulnerability in Health Research Ethics, RIZKY HARNAWAN

TEACHING


Master
  1. (2023) MQF7003 - Foundations of Research Ethics
  2. (2023) MQF7008 - Practicum in Health Reserach Ethics
  3. (2022) MQF7003 - Foundations of Research Ethics
  4. (2022) MQF7008 - Practicum in Health Reserach Ethics
  5. (2021) MQF7003 - Foundations of Research Ethics
Bachelor
  1. (2023) DIA2004 - Pathology
  2. (2023) PBL - Ummp Block 9 Renal
  3. (2023) MQF7003 - Foundations of Research Ethics, University of Southern California 
  4. (2023) MQF7003 - Foundations of Research Ethics, University of Southern California 
  5. (2022) DIA2004 - Pathology
  6. (2022) PBL - Prblem Based Learning

COURSE ATTENDED


Internal / External Course
INTERNAL COURSE- ORGANIZED BY PTJ
  1. PENGURUSAN DAN PERSEDIAAN MESYUARAT ATAS TALIAN, Secara Atas Talian (22 Jun 2021 - 22 Jun 2021)
  2. BELAJAR ASAS DAN REKABENTUK MENGGUNAKAN CANVA, Fakulti Perubatan (15 Jun 2021 - 15 Jun 2021)
  3. C3BIRD-UM GLP & GCP TRAINING, Penganjuran Kursus Secara Atas Talian (Online) (26 Oct 2021 - 26 Oct 2021)
  4. DESIGN AND DEVELOPMENT OF CONVENTIONAL POLYMERASE CHAIN REACTION (PCR) TECHNIQUE, Nanocat, Tingkat 3, Blok a, Ias, UM (09 Jul 2021 - 09 Jul 2021)
  5. C3BIRD-UM GLP & GCP TRAINING, Penganjuran Kursus Secara Atas Talian (Online) (28 Oct 2021 - 28 Oct 2021)
  6. C3BIRD-UM GLP & GCP TRAINING, Penganjuran Kursus Secara Atas Talian (Online) (27 Oct 2021 - 27 Oct 2021)
  7. FOUNDATIONS OF ASSESSMENT FOR HEALTH PROFESSIONALS 03 MARCH 2022, Online-Microsoft Teams (03 Mar 2022 - 03 Mar 2022)
  8. C3BIRD-UM GLP & GCP TRAINING, Penganjuran Kursus Secara Atas Talian (Online) (29 Oct 2021 - 29 Oct 2021)
  9. ESSENTIALS OF TEACHING AND LEARNING JULY 2022, Microsoft Teams Online (18 Jul 2022 - 19 Jul 2022)
  10. PROFESSIONALISM IN THE WORKPLACE - DEALING WITH ATTITUDE, Microsoft Teams (02 Jun 2022 - 02 Jun 2022)
  11. EMERALD TEACHING AND LEARNING 2022, Online (08 Aug 2022 - 12 Aug 2022)
  12. EMERALD RESEARCH AND SUPERVISION, UM (16 Aug 2022 - 17 Aug 2022)
  13. FACILITATING SKILLS LEARNING ( OCT 2022), Cube, Aras 4, Fakulti Perubatan, Universiti Malaya (04 Oct 2022 - 04 Oct 2022)
  14. PROFESSIONALISM IN THE WORKPLACE -DEALING WITH ATTITUDE (NOV 2022), Microsoft Teams (01 Nov 2022 - 01 Nov 2022)
CONFERENCE
  1. 22ND FERCAP INTERNATIONAL CONFERENCE, Daegu Catholic University Medical Center (Dcumc) (27 Nov 2022 - 01 Dec 2022)
External Course
NATIONAL
  1. Basic Immunohistochemistry (IHC) & Fluorescent in situ Hybridisation (FISH) Workshop: Application on Formalin-Fixed Paraffin Embedded (FFPE) Tissue, Hospital Ampang, Kkm (08 Apr 2015 - 09 Apr 2015)
  2. Training on Research Ethical Updates by CRM and MREC MOH, Online (08 Jun 2022 - 08 Jun 2022)
  3. Hands-on Intermediate Statistical Analysis Workshop 2018 (UMBI), Umbi, UKM (05 Feb 2018 - 07 Feb 2018)
  4. Seminar Pengenalan Keselamatan Dan Kesihatan Di Tempat Kerja, Hospital Ampang, Kkm (27 Apr 2010 - 27 Apr 2010)
  5. Seminar: National Laboratory Accreditation ISO15189, Hospital Ampang, Kkm (01 Mar 2010 - 01 Mar 2010)
  6. Haematology Update 2010 Towards Standard Practices in Haematology, Hospital Ampang, Kkm (01 Oct 2010 - 02 Oct 2010)
  7. IT Skill Assessment and Certification (ISAC) by Institut Tadbiran Awam Negara (INTAN), Institut Tadbiran Awam Negara (Intan), Pj (25 Aug 2010 - 25 Aug 2010)
  8. Strategic Communication to Strengthen Salt Reduction Action in Malaysia, Putrajaya, Nih Moh Malaysia (09 Sep 2020 - 11 Sep 2020)
  9. Online Workshop on Research Grant Proposal Writing: Attaining Essential Quality for Success, PPGP (11 Nov 2020 - 11 Nov 2020)
  10. HeRO: Manuscript Writing Made Easy online course, Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Online (02 Nov 2020 - 27 Nov 2020)
  11. 2021 YSN-ASM Colloqium , Asm Malaysia (04 Nov 2021 - 05 Nov 2021)
  12. Merck Chemical Spillage & Safety Workshop, Hospital Ampang, Kkm (13 Apr 2011 - 13 Apr 2011)
  13. Future of Healthcare in Malaysia 2030 + Foresight Workshop, Nih Moh Malaysia (11 Aug 2020 - 12 Aug 2020)
  14. Kursus Penulisan Laporan Saintifik Penyelidikan Kumpulan Pengurusan dan Profesional Sains Kesihatan Bersekutu, Anjuran Bahagian Sains Kesihatan Bersekutu, Kementerian Kesihatan Malaysia, Bahagian Sains Kesihatan Bersekutu, Kementerian Kesihatan Malaysia (14 Dec 2010 - 16 Dec 2010)
  15. How to Write A Dissertation Workshop, Faculty of Medicine, Universiti Malaya (15 Jan 2020 - 16 Jan 2020)
  16. Kursus Analisis Statistik Penyelidikan Kumpulan Pengurusan Profesional Sains Kesihatan Bersekutu, Kumpulan Pengurusan Profesional Sains Kesihatan Bersekutu, Kkm Putrajaya (27 Sep 2010 - 30 Sep 2010)
  17. Kursus Tatacara Pengurusan Perolehan Secara Sebut Harga, Hospital Ampang, Kkm (03 Aug 2010 - 03 Aug 2010)
  18. Research Methodology Workshop, MOHRE with Johns Hopkins University , Faculty of Medicine, Universiti Malaya (01 Nov 2019 - 01 Nov 2019)
  19. 1st Molecular Pathology Symposium , Pantai Premier Pathology (22 Jul 2018 - 22 Jul 2018)
  20. Seminar on Stem Cell Research and Therapy, Hospital Ampang, Kkm (11 Aug 2009 - 11 Aug 2009)
  21. Workshop on Systematic Review and Meta-analysis for Medical/Health Interventions, Online (21 Jun 2022 - 22 Jun 2022)
INTERNATIONAL
  1. 2020 NIH Ethical and Regulatory Aspects of Clinical Research, Department of Bioethics, National Institute of Health, United States of America, Online (01 Sep 2020 - 02 Nov 2020)
  2. FERCAP Annual International Conference 2020, Online (24 Nov 2020 - 27 Nov 2020)
  3. FERCAP Annual International Conference 2021, Online (06 Dec 2021 - 09 Dec 2021)
  4. FERCAP Annual International Conference 2019, Universiti Sains Malaysia, Penang, Malaysia (24 Nov 2019 - 27 Nov 2019)
  5. First ASEAN Federation of Haematology & VIIIth Malaysian Society of Haematology Scientific Meeting, Hospital Ampang, Kkm (22 Apr 2010 - 24 Apr 2010)