Curriculum Vitae

ASSOCIATE PROF. DR. DHARMANI DEVI A/P MURUGAN

Associate Professor
  • Department of Pharmacology
    Faculty of Medicine
  • dharmani79
  • 0379674952

AREAS OF EXPERTISE

  • MOLECULAR PHARMACOLOGY
    Cellular and molecular mechanism of Drug action ( oxidative stress, endothelial dysfunction etc)
  • TRADITIONAL MEDICINE AND NATURAL PRODUCT
    Natural Product-Based Therapeutics for metabolic diseases
  • VASCULAR PHARMACOLOGY,
    renin-angiotensin system, oxidative stress, endoplasmic reticulum stress, antioxidants, metabolic diseases, isolated tissue preparations

ACADEMIC QUALIFICATION

  • PhD, (cardiovascular pharmacology)
    Universiti Malaya (UM)
  • BBioMedSc(Hons), (Sains Bioperubatan)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • Coordinator
    15 Oct 2021 - 30 Sep 2025 (Department of Pharmacology, Faculty of Medicine)
  • Committee Members
    01 Mar 2020 - 28 Feb 2025 (Department of Pharmacology, Faculty of Medicine)
  • Coordinator
    26 Jan 2015 - 31 Dec 2024 (Department of Pharmacology, Faculty of Medicine)
  • Coordinator
    01 Jan 2022 - 31 Dec 2023 (Department of Pharmacology, Faculty of Medicine)
  • Research Coordinator
    01 Sep 2015 - 31 Dec 2021 (Department of Pharmacology, Faculty of Medicine)
  • Acting Head of Department
    19 Oct 2019 - 31 Jan 2020 (Department of Pharmacology, Faculty of Medicine)
  • AJK Curiculum for Postgraduate Studies Faculty (JKKF) Faculty of Medicine
    05 Apr 2017 - 31 Dec 2020 (Department of Pharmacology, Faculty of Medicine)
  • Coordinator of Pharmacology course for Biomedical Science Programme
    01 Jul 2009 - 30 May 2018 (Department of Pharmacology, Faculty of Medicine)
  • Academic Advisor UMMP Stage 1 2015/2016
    21 Aug 2015 - 19 Aug 2016 (Department of Pharmacology, Faculty of Medicine)
  • Committee member for post graduate evaluation (JKIT) departmental level
    26 Apr 2013 - 01 Jan 2015 (Department of Pharmacology, Faculty of Medicine)
  • Committee member Safety and Occupational Health Committee(Faculty of Medicine)
    05 May 2009 - 31 Dec 2012 (Department of Pharmacology, Faculty of Medicine)

MEMBERSHIPS

  • MALAYSIAN SOCIETY FOR MOLECULAR BIOLOGY AND BIOTECHNOLOGY, TREASURER
    2018 to present (National)
  • MYBIOMED , TREASURER
    Since 2017 (National)
  • MALAYSIAN SOCIETY OF PHARMACOLOGY AND PHYSIOLOGY, TREASURER
    Since 2008 (National)
  • LABORATORY ANIMAL SCIENCE ASSOCIATION OF MALAYSIA (LASAM), MEMBER
    2013 to 2022 (National)
  • ASIAN SOCIETY OF VASCULAR BIOLOGY (ASVB), CO-OPTED EXCO MEMBER
    2018 to 2020 (International)

AWARD AND STEWARDSHIP

  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2016 (University)
  • Best oral presentation (Phd Student Celine Choy Ker Woon)Paeonol Protects Against Endoplasmic Reticulum Stress-Induced Endothelial Dysfunction via AMPK/PPARδ Signalling Pathway. International Postgraduate Research Awards Seminar (InPRAS2016). 7-8th March 2016,University of Malaya
    Malaysian Society of Molecular Biology and Biotechnology, 2016 (International)
  • Best oral presentation (PhD student Ling Wei Chih) -Joint meeting of the 6th Scientific Meeting of The Asian Society for Vascular Biology and the 13th Symposium on Vascular Neuroeffector Mechanisms, held in association with the 28th Scientific Meeting of The Malaysian Society of Pharmacology and Physiology in Aug 2014
    Asian Vascular Biology Society, 2014 (International)
  • CERTIFICATE OF EXCELLENT SERVICE
    University of Malaya, 2012 (University)
  • Best poster award (PhD student)
    Malaysian Society of Hypertension, 2012 (National)
  • best poster award
    Malaysian Society of Pharmacology and Physiology (MSPP), 2008 (National)
  • Recipient of SEAWP travel award
    Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 2008 (International)
  • best oral award
    Malaysian Society of Pharmacology and Physiology (MSPP), 2006 (University)
  • Best poster award
    Malaysian Society of Pharmacology and Physiology (MSPP), 2005 (National)
  • Best oral award
    Malaysian Society of Pharmacology and Physiology (MSPP), 2004 (National)
  • Best poster award
    Malaysian Society of Pharmacology and Physiology (MSPP), 2003 (National)

PUBLICATIONS

Article in Journal
WoS
  1. Sofiullah, Siti Sarah M.; Murugan, Dharmani Devi; Abd Muid, Suhaila; Seng, Wu Yuan; Zamakshshari, Nor Hisam; Gan, Quan Fu; Patrick, Melonney; Ab Azis, Norasikin; Sirasanagandla, Srinivasa Rao; Woon, Choy Ker (2024). Thymoquinone Reverses Homocysteine-Induced Endothelial Dysfunction via Inhibition of Endoplasmic Reticulum-Stress Induced Oxidative Stress Pathway, SAINS MALAYSIANA. 53(3), 591-604. doi:10.17576/jsm-2024-5303-09
  2. Zhang, Peng; Gou, Lingshan; Murugan, Dharmani Devi; Zhang, Hongsong (2024). Editorial: Epigenetic and genetic mechanisms underlying cardiovascular diseases and neurodevelopmental disorders, FRONTIERS IN GENETICS. 15. doi:10.3389/fgene.2024.1401354
  3. Khor, Yucinda Y. Y.; Lee, Siew-Keah; Devi, M. Dharmani; Ling, Wei Chih (2023). Epigallocatechin-3-gallate exerts antihypertensive effects and improves endothelial function in spontaneously hypertensive rats, ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE. 13(7), 287-295. doi:10.4103/2221-1691.380560
  4. Sofiullah, Siti Sarah M.; Murugan, Dharmani Devi; Abd Muid, Suhaila; Seng, Wu Yuan; Kadir, Sharifah Zamiah Syed Abdul; Abas, Razif; Ridzuan, Nurul Raudzah Adib; Zamakshshari, Nor Hisam; Woon, Choy Ker (2023). Natural Bioactive Compounds Targeting NADPH Oxidase Pathway in Cardiovascular Diseases, MOLECULES. 28(3). doi:10.3390/molecules28031047
  5. Wong, Li Ping; Alias, Haridah; Tan, Kit Mun; Wong, Pooi Fong; Murugan, Dharmani Devi; Hu, Zhijian; Lin, Yulan (2023). Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-related disorder: a qualitative study, FRONTIERS IN PHARMACOLOGY. 14. doi:10.3389/fphar.2023.1254470
  6. Geo, Hui Nee; Murugan, Dharmani Devi; Chik, Zamri; Norazit, Anwar; Foo, Yiing Yee; Leo, Bey Fen; Teo, Yin Yin; Kadir, Sharifah Zamiah Syed Binti Syed Abdul; Chan, Yinghan; Chai, Hann Juang; Medel, Maria; Abdullah, Nor Azizan; Johns, Edward J.; Vicent, Maria J.; Chung, Lip Yong; Kiew, Lik Voon (2022). Renal Nano-drug delivery for acute kidney Injury: Current status and future perspectives, JOURNAL OF CONTROLLED RELEASE. 343, 237-254. doi:10.1016/j.jconrel.2022.01.033
  7. Sabri, Nurul Aiza Mohd; Lee, Siew-Keah; Murugan, Dharmani Devi; Ling, Wei Chih (2022). Epigallocatechin gallate (EGCG) alleviates vascular dysfunction in angiotensin II-infused hypertensive mice by modulating oxidative stress and eNOS, SCIENTIFIC REPORTS. 12(1). doi:10.1038/s41598-022-21107-5
  8. Choy, K. W., Zain, Z. M., Murugan, D. D., Giribabu, N., Zamakshshari, N. H., Lim, Y. M., & Mustafa, M. R. (2021). Effect of Hydrolyzed Bird's Nest on beta-Cell Function and Insulin Signaling in Type 2 Diabetic Mice. Frontiers in Pharmacology, 12, 11. doi: 10.3389/fphar.2021.632169
  9. Murugan, D. D., Balan, D., & Wong, P. F. (2021). Adipogenesis and therapeutic potentials of antiobesogenic phytochemicals: Insights from preclinical studies. Phytotherapy Research, 35(11), 5936-5960. doi: 10.1002/ptr.7205
  10. Vellasamy, S., Murugan, D., Abas, R., Alias, A., Seng, W. Y., & Woon, C. K. (2021). Biological Activities of Paeonol in Cardiovascular Diseases: A Review. Molecules, 26(16), 16. doi: 10.3390/molecules26164976
  11. Zhou, Y., Murugan, D. D., Khan, H., Huang, Y., & San Cheang, W. (2021). Roles and Therapeutic Implications of Endoplasmic Reticulum Stress and Oxidative Stress in Cardiovascular Diseases. Antioxidants, 10(8), 17. doi: 10.3390/antiox10081167
  12. Murugan, Dharmani Devi; Zain, Zuhaida Md; Choy, Ker Woon; Zamakshshari, Nor Hisam; Choong, Mel June; Lim, Yang Mooi; Mustafa, Mohd Rais (2020). Edible Bird's Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction, FRONTIERS IN PHARMACOLOGY. 10. doi:10.3389/fphar.2019.01624
  13. Vijeepallam, K., Pandy, V., Murugan, D. D., & Kuppusamy, M. N. (2020). Methanolic Extract of Mitragyna speciosa Korth Leaf Exhibits Place Preference Only at Higher Doses in Mice. Pharmacognosy Magazine, 16(71), 449-454. doi: 10.4103/pm.pm_62_20
  14. Dharmani, M., Kamarulzaman, K., Giribabu, N., Choy, K. W., Zuhaida, M. Z., Aladdin, N. A., . . . Mustafa, M. R. (2019). Effect of Marantodes pumilum Blume (Kuntze) var. alata on beta-cell function and insulin signaling in ovariectomised diabetic rats. Phytomedicine, 65, 12. doi:10.1016/j.phymed.2019.153101
Others
  1. Vellasamy S, Murugan D, Abas R, Alias A, Seng WY, Woon CK. (2021). Biological Activities of Paeonol in Cardiovascular Diseases: A Review. Molecules. 2021 Aug 17;26(16):4976. doi: 10.3390/molecules26164976.
  2. Murugan DD, Md Zain Z, Choy KW, Zamakshshari NH, Choong MJ, Lim YM, Mustafa MR. (2020). Edible Bird's Nest Protects Against Hyperglycemia-Induced Oxidative Stress and Endothelial Dysfunction. Front Pharmacol. 2020 Feb 4;10:1624. doi: 10.3389/fphar.2019.01624. eCollection 2019.
  3. Therapeutic Implications of Nitrite in Hypertension WC Ling, MR Mustafa, DD Murugan Journal of Cardiovascular Pharmacology 75 (2), 123-134
  4. Choy, KW; Murugan, D; Leong, XF; Abas, R; Alias, A; Mustafa, MR 2019. Flavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NF kappa B) Signaling in Cardiovascular Diseases: A Mini Review. FRONTIERS IN PHARMACOLOGY
  5. Dharmani, M., Kamarulzaman, K., Giribabu, N., Choy, K. W., Zuhaida, M. Z., Aladdin, N. A., Jamal, J. A., & Mustafa, M. R. (2019). Effect of Marantodes pumilum Blume (Kuntze) var.alata on -cell function and insulin signaling in ovariectomised diabetic rats. Phytomedicine, 65, 153101. https://doi.org/https://doi.org/10.1016/j.phymed.2019.153101
  6. Khalilpourfarshbafi, M; Gholami, K; Murugan, DD; Sattar, MZA; Abdullah, NA 2019. Differential effects of dietary flavonoids on adipogenesis. EUROPEAN JOURNAL OF NUTRITION
  7. Khalilpourfarshbafi, M; Murugan, DD; Sattar, MZA; Sucedaram, Y; Abdullah, NA 2019. Withaferin A inhibits adipogenesis in 3T3-F442A cell line, improves insulin sensitivity and promotes weight loss in high fat diet-induced obese mice. PLOS ONE
  8. Vijeepallam K, Pandy V, Murugan DD, Naidu M. (2019). Methanolic extract of Mitragyna speciosa Korth leaf inhibits ethanol seeking behaviour in mice: involvement of antidopaminergic mechanism. Metab Brain Dis. doi: 10.1007/s11011-019-00477-2.
  9. Balan D, Chan KL, Murugan D, AbuBakar S, Wong PF. (2018). Antiadipogenic effects of a standardized quassinoids enriched fraction and eurycomanone from Eurycoma longifolia. Phytother Res. 32(7):1332-1345. DOI:10.1002/ptr.6065
  10. Choy KW, Lau YS, Murugan D, Vanhoutte PM, Mustafa MR. (2018). Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently. J Pharmacol Exp Ther., 364(3):420-432.
  11. Choy KW, Murugan D, Mustafa MR. (2018). Natural products targeting ER stress pathway for the treatment of cardiovascular diseases. Pharmacol. Res, 132, 119-129
  12. Khalilpourfarshbafi M, Gholami K, Murugan DD, Abdul Sattar MZ, Abdullah NA. (2018). Differential effects of dietary flavonoids on adipogenesis. Eur J Nutr, doi:10.1007/s00394-018-1663-8
  13. Wei Chih Ling, Mohd Rais Mustafa, Paul M Vanhoutte, Dharmani Devi Murugan. (2018). Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascul Pharmacol. 2018 Mar;102:11-20.
  14. Kunasegaran T, Mustafa MR, Achike FI, Murugan DD. (2017). Quercetin and pioglitazone synergistically reverse endothelial dysfunction in isolated aorta from fructose-streptozotocin (F-STZ)-induced diabetic rats.Eur J Pharmacol. 2017 Mar 15;799:160-170
  15. Ling WC, Liu J, Lau CW, Murugan DD, Mustafa MR, Huang Y. (2017).Treatment with salvianolic acid B restores endothelial function in angiotensin II-induced hypertensive mice. Biochem Pharmacol. 2017 Jul 15;136:76-85.
  16. Wei Chih Ling, Mohd Rais Mustafa, Paul M Vanhoutte, Dharmani Devi Murugan. (2017). Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascul Pharmacol. 2017 May 26. pii: S1537-1891(16)30268-3
  17. Batumalaie K, Amin MA, Murugan DD, Sattar MZ, Abdullah NA. (2016). Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation. Scientific Reports. Sci Rep. 2016 Jun 2;6:27236
  18. Choy KW, Mustafa MR, Lau YS, Liu J, Murugan D, Lau CW, Wang L, Zhao L, Huang Y. 2016.Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPAR signaling pathway. Biochem Pharmacol. 2016 Sep 15;116:51-62.
  19. Ling WC, Murugan DD, Lau YS, Vanhoutte PM, Mustafa MR. (2016). Sodium nitrite exerts an antihypertensive effect and improves endothelial function through activation of eNOS in the SHR. Sci Rep. 2016 Sep 12;6:33048
  20. Murugan D, Lau YS, Lau CW, Mustafa MR, Huang Y (2015). Angiotensin 1-7 Protects against Angiotensin II-Induced Endoplasmic Reticulum Stress and Endothelial Dysfunction via Mas Receptor.PLoS One. PLoS One. 2016 Jan 22;11(1):e0147892. doi: 10.1371/journal.pone.0147892.
  21. Thubasni Kunasegaran,Mohd Rais Mustafa,Dharmani Devi Murugan, Francis I Achike. (2016).The bioflavonoid quercetin synergises with PPAR- agonist pioglitazone in reducing angiotensin-II contractile effect in fructose-streptozotocin induced diabetic rats. Biochimie, (accepted)
  22. Lau Y.S., Ling, W.C, Murugan D, Kwan C.Y. and M.R. Mustafa, 2015. Endothelium-Dependent Relaxation Effect of Apocynum venetum Leaf Extract via Src/PI3K/Akt Signalling Pathway. Nutrients 2015, 7, 5239-5253; doi:10.3390/nu7075220
  23. Lau YS, Ling WC, Murugan D, Mustafa MR. (2015) Boldine Ameliorates Vascular Oxidative Stress and Endothelial Dysfunction: Therapeutic Implication for Hypertension and Diabetes. J Cardiovasc Pharmacol. 2015 Jun;65(6):522-31.
  24. Ling WC, Lau YS, Murugan DD, Vanhoutte PM, Mustafa MR.2015.Sodium nitrite causes relaxation of the isolated rat aorta: By stimulating both endothelial NO synthase and activating soluble guanylyl cyclase in vascular smooth muscle.Vascul Pharmacol. 2015 Jun 2. pii: S1537-1891(15)00128-7. doi: 10.1016/j.vph.2015.05.014. [Epub ahead of print]
  25. Loh WM, Ling WC, Murugan DD, Lau YS, Achike FI, Vanhoutte PM, Mustafa MR.(2015).Des-aspartate angiotensin I (DAA-I) reduces endothelial dysfunction in the aorta of the spontaneously hypertensive rat through inhibition of angiotensin II-induced oxidative stress. Vascul Pharmacol. pii: S1537-1891(15)00053-1. doi: 10.1016/j.vph.2015.03.011
  26. Vijayapandi Pandy*, Megala Narasingam, Thubasni Kunasegaran, Dharmani Devi Murugan, and Zahurin Mohamed, Effect of Noni (Morinda citrifolia Linn.) Fruit and Its Bioactive Principles Scopoletin and Rutin on Rat Vas Deferens Contractility: An Ex Vivo Study, (Q1 ISI indexed Impact factor: 1.73).THE SCIENTIFIC WORLD JOURNAL 2014:909586 JUNE 2014 Impact Factor: 1.73 DOI: 10.1155/2014/909586
  27. Lau YS, Tian XY, Huang Y, Murugan D, Achike FI, Mustafa MR. 2012. Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism.Biochem Pharmacol. Nov 23
  28. Yeh Siang Lau, Xiao Yu Tian, Mohd Rais Mustafa, Dharmani Murugan, Jian Lui, Chi Wai Lau, Yu Huang. (2013). Boldine improves endothelial function in diabetic db/db mice through inhibiting angiotensin II-mediated BMP4- oxidative stress cascade. Br. J. Pharmacol.(accepted)
  29. Arif-ullah Khan1, Mohamad Rais Mustafa, Asif Ullah Khan and Dharmani Devi Murugan.2012.Hypotensive effect of Gentiana floribunda is mediated through Ca++ antagonism pathway.BMC Complementary and Alternative Medicine,12:121
  30. Y.S. Lau, C.Y.Kwan, T.C.Ku, W.T.Hsieh, H.D.Wang, S.Nishibe, M.Dharmani, M.R.Mustafa. 2012. Apocynum venetum leaf extract, an antihypertensive herb,inhibits rat aortic contraction induced by angiotensin II: A nitric oxide and superoxide connection.Journal of Ethanopharmacology
  31. Arif-ullah Khan, Riaz Ullah, Asifullah Khan, Mohamad Rais Mustafa, Javid Hussain,Dharmani Devi Murugan, A. Hamid Bin A. Hadi,Vasodilator Effect of Phlomis bracteosa Constituents Is Mediated through Dual Endothelium-Dependent and Endothelium-Independent Pathways,Clinical and Experimental Hypertension, Early Online: 1 8, (2011)
  32. Yeh-Siang, L.; Subramaniam, G.; Hadi, A.H.A.; Murugan, D.; Mustafa, M.R. Reactive Oxygen Species-Induced Impairment of Endothelium-Dependent Relaxations in Rat Aortic Rings: Protection by Methanolic Extracts of Phoebe grandis. Molecules 2011, 16, 2990-3000.
  33. Syed Putra Muharis, Abdul Gapor Md Top, Dharmani Murugan, Mohd Rais Mustafa.(2010).Palm oil vitamin E restores endothelium dependent relaxation in aortic rings of streptozotocin -induced diabetic and spontaneously hypertensive rats. Nutrition Research (accepted)
  34. M. Dharmani, M.R. Mustafa, F.I. Achike and M.K.Sim (2008). Involvement of AT1 receptor on the vasomodulatory effect of des-Asp-angiotensin I in the rat renal vasculature.Peptides.29(10):1773- 1780.
  35. Dharmani M, Mustafa MR, Achike FI and Sim MK. (2007).Effects of Angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and Streptozotocin (STZ)-induced diabetic rats.Eur. J. Pharmacol. 561(1- 3), 144-150
  36. Dharmani M, Mustafa MR, Achike FI and Sim MK. (2005). Effects of des-Asp-angiotensin I on the action of angiotensin II in isolated renal and mesenteric vasculature of normo- and hypertensive and STZ-induced diabetic rats.Regulatory Peptides.129(1-3),213-219
  37. Kuppusamy UR, Dharmani M, Kanthimathi MS, Indran M. (2005).Antioxidant enzyme activities of human peripheral blood mononuclear cells exposed to trace elements.Biological Trace Element Research.106(1),29-40
  38. Mustafa MR, Dharmani M, NK Kuhneen and Sim MK. 2004. Effects of des-Asp-angiotensin I on the action of angiotensin III in isolated renal and mesenteric vasculature of normo- and hypertensive rats.Regulatory peptides.120(1-3),15-22
Chapter in Books
  1. Achike FI & Dharmani D Murugan. Quercetin and Antioxidant Potential in Diabetes. Diabetes: Oxidative Stress and Antioxidants. 2nd Edition. 2020. Academic Press. pg 293-302
Article in Proceeding
  1. S Zainalabidin, N F Aziz, D D Murugan, M K Mahadi, S-Allylcysteine limits cardiac structural changes via antioxidant status in ovariectomized rats with induced myocardial injury, European Heart Journal, Volume 44, Issue Supplement_1, February 2023, ehac779.135,
  2. Murugan D, Lau YS, Lau CW, Mustafa MR, Huang Y (2016). Angiotensin 1-7 Protects against Angiotensin II-Induced Endoplasmic Reticulum Stress and Endothelial Dysfunction via Mas Receptor. Proceedings of the British Pharmacological Society at http://pA2online.org/abstracts/Vol13Issue3abst047P.pdf
Other Publications
  1. S Zainalabidin, N F Aziz, D D Murugan, M K Mahadi, S-Allylcysteine limits cardiac structural changes via antioxidant status in ovariectomized rats with induced myocardial injury, European Heart Journal, Volume 44, Issue Supplement_1, February 2023, ehac779.135, - Meeting Abstract

RESEARCH PROJECT

National
  1. 2022 - 2025, Fundamental Research Grant Scheme (FRGS)
    In-Vivo, Biochemical And Molecular Mechanisms For The Angiotensin Converting Enzyme (ACE)-Inhibitory Effects Of Lignosus Rhinocerus In Alleviating Vascular Dysfunction In Hypertension ( Principal Investigator(PI))
  2. 2021 - 2024, Fundamental Research Grant Scheme (FRGS)
    Investigating The Vascular Effect And Molecular Mechanisms Of L. Rhinocerus, A Malaysian Medicinal Mushroom Against Age- Induced Endothelial Dysfunction In Atherosclerosis ( Co-Researcher)
  3. 2020 - 2023, Others MOHE - Top 100 (IIRG)-FNW
    Identification Of Senotherapeutics For Vascular Aging ( Co-Researcher)
  4. 2017 - 2021, Fundamental Research Grant Scheme (FRGS)
    Novel Mechanisms Of Actions For The Anti-obesity And Anti-diabetic Effects Of 'withaferin A' In 3t3-f442a Preadipocyte Cell Line And Diet-induced Obese C57bl/j Mice ( Co-Researcher)
  5. 2017 - 2018, Bantuan Kecil Penyelidikan (BKP)
    The Role of FGF21 in mediating the metabolic effects of "Withaferin A" on Insulin Sensitivity and Browning of White Adipocytes in 3T3-F442A Pre-adipocyte cell lines and diet induced obese mice ( Consultant)
  6. 2015 - 2017, NKEA Pertanian Research Scheme
    Protective effects of standardised Labisia pumila extracts against vascular dysfunction in diabetes ( Consultant)
  7. 2014 - 2017, NKEA Pertanian Research Scheme
    Effect of Eurycoma longifoliaon adipogenesis. ( Consultant)
  8. 2013 - 2016, High Impact Research (HIR)
    MAPPING NEURONAL GENETIC CHANGES IN SALT INDUCED HYPERTENSION ( Consultant)
  9. 2012 - 2014, High Impact Research (HIR)
    Mechanisms of the cardiovascular therapeutic potentials of boldine and nitrite in animal models of diabetes mellitus and hypertension H- 20001-00-E000055 ( Consultant)
  10. 2011 - 2014, High Impact Research (HIR)
    Circulating microRNAs as Novel Biomarkers for Early Detection of Atherosclerosis ( Consultant)
  11. 2012 - 2014, Postgraduate Research Grant(PPP)
    Effect of des-asp-angiotensin I and angiotensin 1- 7 treatment on the cardiovascular function and angiotensin receptors in the hypertensive rat model ( Principal Investigator(PI))
  12. 2011 - 2013, High Impact Research (HIR)
    Exploring the cardiovascular mechanisms for the potential use of quercetin as an adjuvant to metformin/pioglitazone in management of type diabetic rat model ( Principal Investigator(PI))
  13. 2011 - 2012, Geran Penyelidikan Universiti Malaya (UMRG)
    Endothelial protective activity of aporphine alkaloids in animals models of diabetes mellitus and hypertension ( Principal Investigator(PI))
  14. 2011 - 2011, Fundamental Research Grant Scheme (FRGS)
    Effect on Des-Asp-Angiotensin I on improving endothelial dysfunction ( Principal Investigator(PI))
  15. 2007 - 2009, Fundamental Research Grant Scheme (FRGS)
    Effect of chronic treatment of angiotensin peptides in the development of diabetes in type 2 diabetes mellitus in Goto-Kakizaki rats ( Consultant)
  16. 2008 - 2009, Short Term Research Fund (Vote F)(PJP)
    Effects of WSG 1002, a tetrahydrobiopterin analogue, treatment in an animal model of atherosclerosis ( Consultant)
  17. 2008 - 2009, Postgraduate Research Grant(PPP)
    Effect of chronic treatment of des-Asp- angiotensin I on the cardiovascular function and angiotensin receptors in the Spontaneously Hypertensive rats. ( Principal Investigator(PI))
  18. 2005 - 2007, Short Term Research Fund (Vote F)(PJP)
    Effect of angiotensin peptides in the renal and mesenteric vasculature of type 1 and type 2- streptozotocin (STZ) induced diabetic rats. ( Consultant)
  19. 2005 - 2006, Postgraduate Research Grant(PPP)
    Effect of angiotensin peptides in the renal and mesenteric vasculature of type 1 and type 2 diabetic animal models ( Principal Investigator(PI))
  20. 2004 - 2005, Postgraduate Research Grant(PPP)
    Effect of angiotensin peptides in diabetic animals ( Principal Investigator(PI))
University
  1. 2021 - 2024, Private Funding
    The Potential Pharmacological Intervention Of Des-aspartate Angiotensin 1 In Treating Obesity-induced Hypertension ( Co-Researcher)

CONSULTANCY PROJECT

  • Committee Member for Mspp_asvb_vnem_msh_2014, MSPP_ASVB
    01 Jul 2014 - 01 Jul 2013 (International)
  • Examiner for Candidature Defense for Jong Hui Lan, Department of Pharmacolgy
    01 Jul 2011 - 01 Jul 2011 (National)

PAPER PRESENTED

INVITED SPEAKER
  1. Vascular Health: Their Importance in Metabolic Diseases, Science, Technology & Social Sciences Symposium (STSSS) 2021 , Centre for Research and Development Asia Metropolitan University (National) (15 Dec 2021 - 15 Dec 2021)
  2. Dharmani Devi Murugan. (2016). Targeting Angiogenesis in Osteoarthritis. Combined Meeting of the 46th Malaysian Orthopeadic Association and 10th Asean Arthroplasty Association Meeting. 26th-28th May 2016. Persada Johor International Convention Centre, Johor Bharu, Malaysia., Combined Meeting of the 46th Malaysian Orthopeadic Association and 10th Aseasn Arthroplasty Association Meeting., Malaysian Orthopeadic Association (International) (26 May 2016 - 28 May 2016)
ORAL PRESENTER
  1. Des-Asp-Angiotensin I inhibits Angiotensin II induced vasoconstriction and oxidative stress in SHR. Loh WM, Ling WC, Murugan DD, Vanhoutte PM, Lau YS, Achike FI, Mustafa MR., International Postgraduate Research Awards Seminar, University of Malaya (National) (10 Dec 2014 - 11 Dec 2014)
  2. Enfothelium-dependent, eNOS independent relaxation to nitrite in the aorta of the SHR. Ling WC, Murugan DD, Mustafa MR, Vanhoutte PM., Pharmacology and Physiology International Scientific Congress 2014 (MSPP-VNEM-ASVB-MHS 2014), MSPP-ASVB-VNEM-MHS (International) (22 Aug 2014 - 24 Aug 2014)
  3. Dharmani M, Mustafa MR, Achike FI, Sim MK. Effects of des-Asp-angiotensin I on angiotensin subtypes 1 (AT1) receptor in the renal vasculature of STZ-induced diabetic rats. , Seminar Hasil Penyelidikan Universiti Malaya, IPPP, University Malaya (University) (06 Sep 2006 - 07 Sep 2006)
  4. Dharmani M, Mustafa MR, Achike FI and Sim MK. (2004). Effects of des-Asp-angiotensin I on the action of angiotensin II in the isolated mesenteric vasculature of Streptozotocin induced diabetic rats. , 19th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting., Malaysian Society of Pharmacology and Physiology  (National) (17 May 2004 - 18 May 2004)
  5. Mustafa MR, Dharmani M, NK Kuhneen and Sim MK. Vasomodulatory effects of des-Asp-angiotensin I on the rat isolated perfused kidney. , ASCEPT Proceedings., Society of Clinical and Experimental Pharmacologists and Toxicologists Australasian (International) (01 Dec 2003 - 04 Dec 2003)
POSTER PRESENTER
  1. Endothelium dependent relaxation effect of Apocynum venetum leaf extract via Src/PI3K/Akt signaling pathway. Lau YS, Murugan DD, Mustafa MR. , Pharmacology and Physiology International Congress 2014 (MSPP-VNEM-ASVB-MHS 2014), MSPP-ASVB-VNEM-MHS (International) (22 Aug 2014 - 24 Aug 2014)
  2. Exploring the effects of quercetin and metformin combination on the reactivity of aortic tissues from a type 2 diabetic rat model. Thubasni Kunasegaran, Murugan DD, Achike FI, Mustafa MR., Pharmacology and Physiology International Scientific Congress 2014 (MSPP-VNEM-ASVB-MHS 2014), MSPP-ASVB-VNEM-MHS (International) (22 Aug 2014 - 24 Aug 2014)
  3. Differential mechanisms of vasodilator effect of nitrite in normotensive and hypertensive rat aortas, 11th international symposium on mechanism of vasodilation, Zurich Heart Disease and University of Zurich (International) (04 Oct 2013 - 06 Dec 2013)
  4. Endothelial protective effects of boldine in type II diabetes. Lau YS, Tian XY, Murugan D, Mustafa MR, Fifth Scientific Meeting Asian Society for Vascular Biology, Asian Society for Vascular Biology (International) (27 Oct 2012 - 29 Oct 2012)
  5. Boldine improves endothelial function in aorta of hypertensive rats by enhancing nitric oxide bioavailability and inhibiting NADPH-mediated superoxide production, Malaysian Society of Hypertension 9th Annual Scientific Meeting, Malaysian Society of Hypertension (National) (10 Feb 2012 - 12 Feb 2012)
  6. Impaired vascular responses to nitrite in hypertensive rat aorta, Experimental Biology 2011 (International) (09 Apr 2011 - 13 Apr 2011)
  7. Effect of des-Asp-angiotensin I on the vascular functions in the isolated rat aorta of spontaneously hypertensive rats, 24th Scientific Meeting of Malaysian Society of Pharmacology and Physiology, Universiti Teknologi Mara (National) (02 Jun 2010 - 03 Jun 2010)
  8. Antioxidant Activity of Boldine prevents endothelial dysfunction in isolated aorta from hypertensive and diabetic rats, 24th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology, Universiti Teknologi Mara (National) (02 Jun 2010 - 03 Jun 2010)
  9. Mohd Rais Mustafa, Dharmani Murugan, Lau Yeh Siang, Khalijah Awang and A.Hamid Hadi. Inhibition of superoxide-anion mediated impairment on endothelial function by treatment of Phoebe Grandis in the isolated rat aorta, 7th COSTAM/SFFR (Asia/Malaysia) international workshop 2009 and the 4th Beinnial Meeting of SFFR Asia (International) (09 Jul 2009 - 12 Jul 2009)
  10. Song J, Dharmani M, Mustafa MR. (2009). Effects of des-Asp-angiotensin I on vascular reactivity in Goto-Kakizaki (GK) rats. , 23th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting, Malaysian Society of Pharmacology and Physiology (MSPP) and UKM (National) (12 May 2009 - 13 May 2009)
  11. Dharmani M, Mustafa MR, Achike FI, Sim MK. Impaired Vasodepressor action of des-Asp-angiotensin I in the renal vasculature of neonatal-streptozotocin (n-STZ) induced (Type 2) diabetic rat model, 22th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting. , Malaysian Society of Pharmacology and Physiology  (National) (05 Apr 2008 - 06 Apr 2008)
  12. Dharmani M, Mustafa MR, Achike FI, Sim MK. Involvement of AT1 angiotensin receptor in the vasomodulatory effect of des-Asp-angiotensin I in the rat renal vasculature., Joint meeting of the Southeast Asian Western Pasific Regional Federation of Pharmacologists and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. SEAWP-ASCEPT Proceedings., Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists (International) (02 Dec 2007 - 06 Dec 2007)
  13. Mustafa MR, Dharmani M, Achike FI, Sim MK. Effects of Angiotensin 1-7 on angiotensin subtypes 1 (AT1) receptor in the renal vasculature of Spontaneously Hypertensive rats. , Life Sciences 2007. 8th -12th July 2007, , BJP (International) (08 Jul 2007 - 12 Jul 2007)
  14. Dharmani M, Mustafa MR, Achike FI and Sim MK. Effects of angiotensin 1-7 on the action of angiotensin II in the isolated perfused kidney of Streptozotocin induced diabetic rats., 20th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting. , Malaysian Society of Pharmacology and Physiology  (National) (25 Apr 2005 - 26 Apr 2005)
  15. Dharmani M, Mustafa MR, Achike FI and Sim MK. Vasomodulatory effect of des-Asp-angiotensin I on the isolated perfused mesentery. , 18th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting., UKM (National) (26 Apr 2003 - 27 Apr 2003)
OTHERS
  1. Ker Woon Choy, Yeh Siang Lau, Dharmani Murugan, Mohd Rais Mustafa. (2017). Paeonol Attenuates Lipopolysaccharide induced Apoptosis In Human Umbilical Vein Endothelial Cells By Inhibiting BMP4/ROS/MAPK Signaling. 31st Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting. 18th 19th August 2017. Universiti Sains Malaysia, Kelantan, 31st Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting., Malaysian Society of Pharmacology and Physiology (MSPP)  (National) (18 Aug 2017 - 19 Aug 2017)
  2. Boldine treatment improves endothelial dysfunction in streptozotocin-induced diabetes, International Symposium on Vascular Biology 2012, Vascular biology Research Group, CMU (International) (24 Mar 2012 - 24 Mar 2012)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2021) External Examiner for Research Project in Master in Pharmacy Practice, International, (External Examiner)
  2. (2020) penilaian dana penyelidikan, Jabatan Pendidikan Tinggi Kementerian Penggajian Tinggi Tahun 2020. , (Reviewer)
  3. (2017) External Examiner for Masters thesis Lsilvia Si Yiang Nee (UKM) , (External Examiner)
  4. (2016) Evaluation of anti-ulcer and antioxidant activity of 2-nitro-N'-phenylbenzohydrazide in rats. MBEB 4180 Research Project in Biomedical Science (2015 - 2016), (External Examiner)
  5. (2016) Review article for BMC Pharmacology and Toxicology, (Reviewer)
  6. (2016) Review article for Journal of Asian Natural Products Research, (Reviewer)
  7. (2015) Undergraduate thesis entitled Immunological and functional studies on the neutralisation of medically important pit viper venoms, (External Examiner)
  8. (2015) Reviewed an article for Cardiovascular and Experimental Pharmacology and Physiology Journal (CEPP), (Reviewer)
  9. (2015) Evaluate an scientific article for JUMMEC , (Reviewer)
  10. (2013) External examiner for an undergradute thesis for yberjaya university- subacte and acute toxicological study on supplementation of high dose of evening primrose oil in rats, (External Examiner)
  11. (2012) evaluation of dopamine and serotonin receptor binding activity of selected aporphines- vani munusamy MGN090016, (Internal Examiner)
  12. (2009) Association of uridine diphospho glucuronosyltransferase 1 family polypeptide A6 (UGT1A6) gene polymorphism and responsiveness to sodium valproate in epilepsy patients in Malaysia - Rayinda Rahmadhani ( MTEB2180) 2008/2009 , (Internal Examiner)
  13. (2008) Association of FABP2 A54T polymorphism with soium valproate responsiveness in malaysian epilepsy patients- Norhidayah bt mohammad noor (MTEB2180) 2008/2009 , (Internal Examiner)
Contribution to external organisation
  1. (2019) Chairperson of MSPP2019, Malaysian Society of Pharmacology and Physiology
  2. (2017) Organizing committee for 2nd International Conference of Molecular Biology and Biology, Malaysian Society of Molecular Biology and Biotechnology
  3. (2016) Prescription skills workshop, MerDU and FOM
  4. (2015) Invited symposium speaker in Faculty of Medicine Research Week 2015, Department of Pharmacology and Pharmacy, FOM
  5. (2015) Faculty of Medicine Research Week 2015, Department of Pharmacology and Pharmacy, FOM
  6. (2014) Research collaboration: Asooc. Prof. Dr. Suresh Kumar, University of Nottingham Malaysia Campus, National
  7. (2014) Prescription skills workshop , FOM, University of Malaya
  8. (2014) Assesment and accreditation of laboratory animal care international (AAALAC), University Malaya and AAALAC
  9. (2013) Research collaboration: Prof. Francis Achike, College of Medicine, Central Michigan University, International
  10. (2012) Research collaboration : Prof. Huang Yu, Chinese University of Hong Kong, International
  11. (2012) Research collaboration: Prof. Paul Vanhoutte, University of Hong Kong, International
Contribution to event
  1. (2022) Chairperson, International, (Event Organiser)
  2. (2021) Treasurer of Organising Committee in Asian Conference On Biomedical Research and Laboratory Medicine (Acbrlm) 2021, International, (Event Organiser)
  3. (2021) Scientific Team, International, (Event Organiser)
  4. (2021) Scientific Committee and Co-Chair of Session, International, (Event Coordinator)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2024) THE VASCULAR EFFECT AND MOLECULAR MECHANISMS OF L.RHINOCERUS AGAINST ADVANCED GLYCATION END PRODUCTS-INDUCED ENDOTHELIAL DYSFUNCTION IN HIGH-FAT DIET FED MICE MODEL, TAN SUN WERN
  2. (2020) NEUROMODULATARY EFFECT OF MITRAGYNA SPECIOSA KORTH (KRATOM) ON DOPAMINERGIC SYSTEM AND ITS PROTECTIVE EFFECT IN EXPERIMENTAL MODELS OF ALCOHOL DEPENDENCE, KAMINI A/P VIJEEPALLAM
  3. (2020) EFFECT OF WITHAFERIN A ON OBESITY AND OBESITY-RELATED INSULIN RESISTANCE AND THE UNDERLYING MECHANISMS OF ACTION, MANIZHEH KHALILPOURFARSHBAFI
  4. (2017) PHARMACOLOGICAL EFFECTS OF PAEONOL AGAINST ENDOPLASMIC RETICULUM STRESS AND INFLAMMATION-INDUCED ENDOTHELIAL DYSFUNCTION, CHOY KER WOON
  5. (2016) Modulation of Endothelial Function by Sodium Nitrite: Therapeutic Implications for Hypertension., LING WEI CHIH
  6. (2012) ENDOTHELIAL PROTECTIVE ACTIVITY OF BOLDINE IN ANIMAL MODELS OF HYPERTENSION AND DIABETES MELLITUS, LAU YEH SIANG
  7. (2010) ENDOTHELIAL PROTECTIVE ACTIVITY OF BOLDINE IN ANIMAL MODELS OF HYPERTENSION AND DIABETES MELLITUS, LAU YEH SIANG
Master
  1. (2024) The potential pharmacological intervention of Des-aspartate Angiotensin 1 in treating obesity-induced hypertension, ASHOK MANDAL
  2. (2024) Targeting Vascular Aging with Senotherapeutics, TIEN XIN YI
  3. (2023) INVESTIGATING THE VASCULAR PROTECTIVE EFFECT OF L. RHINOCERUS SCLEROTIA EXTRACT IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR)., WONG YI EN
  4. (2022) Investigation of the Protective Effect of Red Yeast Rice Supplementation on the Vascular Dysfunction in Spontaneously Hypertensive Rats, TAN JIUNN JYE (Universiti Tunku Abdul Rahman (Utar))
  5. (2021) DECIPHERING ANTI-DIABETIC AND INSULIN RECEPTOR SENTISIZING ACTIVITIES OF TERMINALIA CHEBULA DERIVED CHEBULAGIC ACID, Vanitha Kanisin (Universiti Putra Malaysia (UPM))
  6. (2019) The effect of S-allycysteine in ovariectomized rats with myocardial injury, Nurrellya Faqhiraah binti Aziz (National University of Malaysia (UKM))
  7. (2019) Modulation of Endothelial Nitric Oxide Synthase (eNOS) by Epigallatocatechin-3-gallate (EGCG) for treatment of vascular dysfunction in hypertension, Nurul Azia Binti Mohd Sabri (Universiti Tunku Abdul Rahman (Utar))
  8. (2019) Investigation of the Vasoprotective Mechanism of Epigallocatechin-3-gallate (EGCG) in Spontaneously Hypertensive Rats, Yucinda Khor Yee Yan (Universiti Tunku Abdul Rahman (Utar))
  9. (2017) In Vitro & In Vivo Anti-Adipogenic Effects of a Standardized Quassinoid Composition from Eurycoma Longifolia., DHARVIND A/L BALAN
  10. (2015) Quercetin Synergizes with Pioglitazone, a PPAR Gamma Agonist, in Improving Endothelial Dysfunction in Diabetic Rat Model., THUBASNI KUNASEGARAN
  11. (2010) Modulatory actions of Des-Aspartate-Angiotensin I on vascular reactivity and endothelial function in aorta from spontaneously hypertensive rats., LOH WEI MEE
  12. (2010) -, LAU YEH SIANG

TEACHING

Bachelor
  1. (2015) MTEJ1116 - Pharmacology and Handling of Medication
  2. (2014) MDEB4401 - Advanced Medical Pharmacology
  3. (2014) UMMP - Pharmacology
  4. (2013) Nursing
  5. (2013) DNED2101 - Farmakologi
  6. (2013) MBBS - Phase Ii -Pharmacology
  7. (2012) MBBS - Phase Ii -Pharmacology
  8. (2011) DNED2101 - Farmakologi
  9. (2011) MBBS - Phase Ii -Pharmacology
  10. (2011) MDEB3401 - Advanced Medical Pharmacology
  11. (2010) MBEB2105 - General Principles in Pharmacology and Toxicology
  12. (2010) MWEF2103 - Central Nervous System & Therapy

SOCIAL RESPONSIBILITY ACTIVITIES

  • Facilitator for Let'S Go to Mummies Lab, (13 Feb 2018 - 13 Feb 2018)