PERSONAL DETAIL


Dr. Dharmani Devi A/P Murugan

Department of Pharmacology
Faculty of Medicine
 
  79677566
  79674791
  dharmani79@um.edu.my
  Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, MALAYSIA
 
Homepage
  http://medicine.um.edu.my/departments/para-cl
ResearcherID Link
  http://www.researcherid.com/rid/B-8436-2010


BIBLIOMETRIC DATA


 Total Articles in Publication List  36
 Articles With Citation Data  36
 Sum of the Times Cited   290
 Average Citations per Article   8.06
 h-index   10
 Co-authors   Collaboration Network
 This information is generated from http://researcherid.com

ACADEMIC QUALIFICATION
(Qualification), (Institution).



PROFESSIONAL
(Organisation), (Role), (Year), (Level).


  • Malaysian Society of Pharmacology and Physiology, Treasurer, 2008 to 2020, (National)
  • Laboratory Animal Science Association of Malaysia (LASAM), Academic Member, 2013 to 2017, (University)
  • MyBiomed , Committee Member, 2017 to 2018, (National)
  • Malaysian Society for Molecular Biology and Biotechnology, Ordinary Member, 2018 to 2018, (National)
  • Asian Society of Vascular Biology (ASVB), Co-opted Member, 2018 to 2020, (International)

ADMINISTRATIVE DUTIES
(Role), (Level), (Start date),(End Date).


  • AJK Curiculum for Postgraduate Studies Faculty (JKKF) Faculty of Medicine, Faculty, 05/04/2017 to 05/04/2019 (AJK Curiculum for Postgraduate Studies Faculty (JKKF) Faculty of Medicine)
  • Committee member of Occupational and Safety (OSH) Faculty of Medicine, UM, Faculty, 01/03/2017 to 30/04/2019 (Committee member of Occupational and Safety (OSH) Faculty of Medicine, UM)
  • Research Coordinator, Faculty, 01/09/2015 to 30/12/2017 (Department Research coordinator)
  • Academic Advisor UMMP Stage 1 2015/2016, Faculty, 21/08/2015 to 19/08/2016
  • Jawatankuasa Ijazah Tinggi Fakulti Perubatan (JKIT)bagi Jabatan Farmakologi, Faculty, 26/01/2015 to 31/12/2018
  • Committee member for post graduate evaluation (JKIT) departmental level, Faculty, 26/04/2013 to 01/01/2015
  • Coordinator, makmal Satelit Haiwan, Jabatan Farmakologi, Faculty, 29/03/2013
  • Coordinator of Pharmacology course for Biomedical Science Programme, Faculty, 01/07/2009 to 30/05/2018 (Course coordinator for Pharmacology)
  • Committee member Safety and Occupational Health Committee(Faculty of Medicine), Faculty, 05/05/2009 to 31/12/2012

AREAS OF EXPERTISE
(Area).


  • Vascular Pharmacology, (renin-angiotensin system, oxidative stress, endoplasmic reticulum stress, antioxidants, metabolic diseases, isolated tissue preparations)


RECENT SELECTED PUBLICATIONS
(Publication).


Article in Academic Journals

2018
  • Wei Chih Ling, Mohd Rais Mustafa, Paul M Vanhoutte, Dharmani Devi Murugan. (2018). Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascul Pharmacol. 2018 Mar;102:11-20. (ISI-Indexed)
  • Choy KW, Lau YS, Murugan D, Vanhoutte PM, Mustafa MR. (2018). Paeonol Attenuates LPS-Induced Endothelial Dysfunction and Apoptosis by Inhibiting BMP4 and TLR4 Signaling Simultaneously but Independently. J Pharmacol Exp Ther., 364(3):420-432. (ISI-Indexed)
  • Khalilpourfarshbafi M, Gholami K, Murugan DD, Abdul Sattar MZ, Abdullah NA. (2018). Differential effects of dietary flavonoids on adipogenesis. Eur J Nutr, doi:10.1007/s00394-018-1663-8 (ISI-Indexed)
  • Choy KW, Murugan D, Mustafa MR. (2018). Natural products targeting ER stress pathway for the treatment of cardiovascular diseases. Pharmacol. Res, 132, 119-129 (ISI-Indexed)

2017
  • Ling WC, Liu J, Lau CW, Murugan DD, Mustafa MR, Huang Y. (2017).Treatment with salvianolic acid B restores endothelial function in angiotensin II-induced hypertensive mice. Biochem Pharmacol. 2017 Jul 15;136:76-85. (ISI-Indexed)
  • Kunasegaran T, Mustafa MR, Achike FI, Murugan DD. (2017). Quercetin and pioglitazone synergistically reverse endothelial dysfunction in isolated aorta from fructose-streptozotocin (F-STZ)-induced diabetic rats.Eur J Pharmacol. 2017 Mar 15;799:160-170 (ISI-Indexed)
  • Wei Chih Ling, Mohd Rais Mustafa, Paul M Vanhoutte, Dharmani Devi Murugan. (2017). Chronic administration of sodium nitrite prevents hypertension and protects arterial endothelial function by reducing oxidative stress in angiotensin II-infused mice. Vascul Pharmacol. 2017 May 26. pii: S1537-1891(16)30268-3 (ISI-Indexed)

2016
  • Choy KW, Mustafa MR, Lau YS, Liu J, Murugan D, Lau CW, Wang L, Zhao L, Huang Y. 2016.Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARδ signaling pathway. Biochem Pharmacol. 2016 Sep 15;116:51-62. (ISI-Indexed)
  • Batumalaie K, Amin MA, Murugan DD, Sattar MZ, Abdullah NA. (2016). Withaferin A protects against palmitic acid-induced endothelial insulin resistance and dysfunction through suppression of oxidative stress and inflammation. Scientific Reports. Sci Rep. 2016 Jun 2;6:27236 (ISI-Indexed)
  • Thubasni Kunasegaran,Mohd Rais Mustafa,Dharmani Devi Murugan, Francis I Achike. (2016).The bioflavonoid quercetin synergises with PPAR- agonist pioglitazone in reducing angiotensin-II contractile effect in fructose-streptozotocin induced diabetic rats. Biochimie, (accepted) (ISI-Indexed)
  • Ling WC, Murugan DD, Lau YS, Vanhoutte PM, Mustafa MR. (2016). Sodium nitrite exerts an antihypertensive effect and improves endothelial function through activation of eNOS in the SHR. Sci Rep. 2016 Sep 12;6:33048 (ISI-Indexed)
  • Murugan D, Lau YS, Lau CW, Mustafa MR, Huang Y (2015). Angiotensin 1-7 Protects against Angiotensin II-Induced Endoplasmic Reticulum Stress and Endothelial Dysfunction via Mas Receptor.PLoS One. PLoS One. 2016 Jan 22;11(1):e0147892. doi: 10.1371/journal.pone.0147892. (ISI-Indexed)

2015
  • Loh WM, Ling WC, Murugan DD, Lau YS, Achike FI, Vanhoutte PM, Mustafa MR.(2015).Des-aspartate angiotensin I (DAA-I) reduces endothelial dysfunction in the aorta of the spontaneously hypertensive rat through inhibition of angiotensin II-induced oxidative stress. Vascul Pharmacol. pii: S1537-1891(15)00053-1. doi: 10.1016/j.vph.2015.03.011 (ISI-Indexed)
  • Ling WC, Lau YS, Murugan DD, Vanhoutte PM, Mustafa MR.2015.Sodium nitrite causes relaxation of the isolated rat aorta: By stimulating both endothelial NO synthase and activating soluble guanylyl cyclase in vascular smooth muscle.Vascul Pharmacol. 2015 Jun 2. pii: S1537-1891(15)00128-7. doi: 10.1016/j.vph.2015.05.014. [Epub ahead of print] (ISI-Indexed)
  • Lau Y.S., Ling, W.C, Murugan D, Kwan C.Y. and M.R. Mustafa, 2015. Endothelium-Dependent Relaxation Effect of Apocynum venetum Leaf Extract via Src/PI3K/Akt Signalling Pathway. Nutrients 2015, 7, 5239-5253; doi:10.3390/nu7075220 (ISI-Indexed)
  • Lau YS, Ling WC, Murugan D, Mustafa MR. (2015) Boldine Ameliorates Vascular Oxidative Stress and Endothelial Dysfunction: Therapeutic Implication for Hypertension and Diabetes. J Cardiovasc Pharmacol. 2015 Jun;65(6):522-31. (ISI-Indexed)

2014
  • Vijayapandi Pandy*, Megala Narasingam, Thubasni Kunasegaran, Dharmani Devi Murugan, and Zahurin Mohamed, Effect of Noni (Morinda citrifolia Linn.) Fruit and Its Bioactive Principles Scopoletin and Rutin on Rat Vas Deferens Contractility: An Ex Vivo Study, (Q1 ISI indexed Impact factor: 1.73).THE SCIENTIFIC WORLD JOURNAL 2014:909586 · JUNE 2014 Impact Factor: 1.73 · DOI: 10.1155/2014/909586 (ISI-Indexed)

2013
  • Yeh Siang Lau, Xiao Yu Tian, Mohd Rais Mustafa, Dharmani Murugan, Jian Lui, Chi Wai Lau, Yu Huang. (2013). Boldine improves endothelial function in diabetic db/db mice through inhibiting angiotensin II-mediated BMP4- oxidative stress cascade. Br. J. Pharmacol.(accepted) (ISI-Indexed)
  • Lau YS, Tian XY, Huang Y, Murugan D, Achike FI, Mustafa MR. 2012. Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism.Biochem Pharmacol. Nov 23 (ISI-Indexed)

2012
  • Y.S. Lau, C.Y.Kwan, T.C.Ku, W.T.Hsieh, H.D.Wang, S.Nishibe, M.Dharmani, M.R.Mustafa. 2012. Apocynum venetum leaf extract, an antihypertensive herb,inhibits rat aortic contraction induced by angiotensin II: A nitric oxide and superoxide connection.Journal of Ethanopharmacology (ISI-Indexed)
  • Arif-ullah Khan1, Mohamad Rais Mustafa, Asif Ullah Khan and Dharmani Devi Murugan.2012.Hypotensive effect of Gentiana floribunda is mediated through Ca++ antagonism pathway.BMC Complementary and Alternative Medicine,12:121 (ISI-Indexed)

2011
  • Arif-ullah Khan, Riaz Ullah, Asifullah Khan, Mohamad Rais Mustafa, Javid Hussain,Dharmani Devi Murugan, A. Hamid Bin A. Hadi,Vasodilator Effect of Phlomis bracteosa Constituents Is Mediated through Dual Endothelium-Dependent and Endothelium-Independent Pathways,Clinical and Experimental Hypertension, Early Online: 1¿8, (2011) (ISI-Indexed)
  • Yeh-Siang, L.; Subramaniam, G.; Hadi, A.H.A.; Murugan, D.; Mustafa, M.R. Reactive Oxygen Species-Induced Impairment of Endothelium-Dependent Relaxations in Rat Aortic Rings: Protection by Methanolic Extracts of Phoebe grandis. Molecules 2011, 16, 2990-3000. (ISI-Indexed)

2010
  • Syed Putra Muharis, Abdul Gapor Md Top, Dharmani Murugan, Mohd Rais Mustafa.(2010).Palm oil vitamin E restores endothelium dependent relaxation in aortic rings of streptozotocin -induced diabetic and spontaneously hypertensive rats. Nutrition Research (accepted) (ISI-Indexed)

2008
  • M. Dharmani, M.R. Mustafa, F.I. Achike and M.K.Sim (2008). Involvement of AT1 receptor on the vasomodulatory effect of des-Asp-angiotensin I in the rat renal vasculature.Peptides.29(10):1773- 1780. (ISI/SCOPUS Indexed Publication)

2007
  • Dharmani M, Mustafa MR, Achike FI and Sim MK. (2007).Effects of Angiotensin 1-7 on the actions of angiotensin II in the renal and mesenteric vasculature of hypertensive and Streptozotocin (STZ)-induced diabetic rats.Eur. J. Pharmacol. 561(1- 3), 144-150 (ISI/SCOPUS Indexed Publication)

2005
  • Dharmani M, Mustafa MR, Achike FI and Sim MK. (2005). Effects of des-Asp-angiotensin I on the action of angiotensin II in isolated renal and mesenteric vasculature of normo- and hypertensive and STZ-induced diabetic rats.Regulatory Peptides.129(1-3),213-219 (ISI/SCOPUS Indexed Publication)
  • Kuppusamy UR, Dharmani M, Kanthimathi MS, Indran M. (2005).Antioxidant enzyme activities of human peripheral blood mononuclear cells exposed to trace elements.Biological Trace Element Research.106(1),29-40 (ISI/SCOPUS Indexed Publication)

2004
  • Mustafa MR, Dharmani M, NK Kuhneen and Sim MK. 2004. Effects of des-Asp-angiotensin I on the action of angiotensin III in isolated renal and mesenteric vasculature of normo- and hypertensive rats.Regulatory peptides.120(1-3),15-22 (ISI/SCOPUS Indexed Publication)
Proceeding

2016
  • Murugan D, Lau YS, Lau CW, Mustafa MR, Huang Y (2016). Angiotensin 1-7 Protects against Angiotensin II-Induced Endoplasmic Reticulum Stress and Endothelial Dysfunction via Mas Receptor. Proceedings of the British Pharmacological Society at http://pA2online.org/abstracts/Vol13Issue3abst047P.pdf (Non-ISI/Non-SCOPUS)

AREAS OF RESEARCH
(Project title), (Role), (From)-(Until), (Level), (Source).


  • The Role of FGF21 in mediating the metabolic effects of "Withaferin A" on Insulin Sensitivity and Browning of White Adipocytes in 3T3-F442A Pre-adipocyte cell lines and diet induced obese mice, Co-Investigator, 2017 - 2018, Bantuan Kecil Penyelidikan (BKP), (National)
  • NOVEL MECHANISMS OF ACTIONS FOR THE ANTI-OBESITY AND ANTI-DIABETIC EFFECTS OF 'WITHAFERIN A' IN 3T3-F442A PREADIPOCYTE CELL LINE AND DIET-INDUCED OBESE C57BL/J MICE, Consultant, 2017 - 2020, Fundamental Research Grant Scheme (FRGS), (National)
  • Elucidating The Molecular Mechanisms Of Vascular Protective Effect Of Paeonol In Lipopolysaccharide (lps)- Induced Inflammation Models., Principal Investigator(PI), 2016 - 2019, Fundamental Research Grant Scheme (FRGS), (National)
  • MECHANISM OF ACTION OF THE DIRECT VASORELAXANT ACTIONS OF DES-ASPARTATE-ANGIOTENSIN I (DAA-I), A POTENTIAL ANTIHYPERTENSIVE PEPTIDE, Principal Investigator(PI), 2016 - 2018, Government Agency, (National)
  • Investigating The Importance Of Edible Bird Nest In The Management Of Type 1 And Type 2 Diabetes, Principal Investigator(PI), 2016 - 2018, Government Agency, (National)
  • Elucidating The Molecular Mechanisms Of Vascular Protective Effect Of Paeonol In Lipopolysaccharide (lps)- Induced Inflammation Models., Consultant, 2016 - 2019, Fundamental Research Grant Scheme (FRGS), (National)
  • Protective effects of standardised Labisia pumila extracts against vascular dysfunction in diabetes, Co-Investigator, 2015 - 2017, NKEA Pertanian Research Scheme, (National)
  • Exploring Cardiovascular Mechanism For The Potential Use Of Quercetin As Adjuvant To Metformin/pioglitazone In Management Of Fructose-stz Induced Metabolic Syndrome Rat Model., Principal Investigator(PI), 2014 - 2016, Postgraduate Research Grant (PPP) - Research, (National)
  • Effect of Eurycoma longifoliaon adipogenesis., Co-Investigator, 2014 - 2017, NKEA Pertanian Research Scheme, (National)
  • Gender And Cardiovascular Diseases, Consultant, 2013 - 2015, Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness), (University)
  • Sentisation To Exogeneous And Endogeneous Nitrites For The Treatment Of Hypertension., Principal Investigator(PI), 2013 - 2016, High Impact Research - Ministry of Education (HIR-MOE) Cycle 3, (National)
  • MAPPING NEURONAL GENETIC CHANGES IN SALT INDUCED HYPERTENSION, Co-Investigator, 2013 - 2016, High Impact Research (HIR), (National)
  • Effect Of Des-asp-angiotensin I (daa-i) On Arteriosclerotic Formation In Apo-e Deficient Mice, Principal Investigator(PI), 2013 - 2014, Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness), (University)
  • Mechanisms of the cardiovascular therapeutic potentials of boldine and nitrite in animal models of diabetes mellitus and hypertension H- 20001-00-E000055, Co-Investigator, 2012 - 2014, High Impact Research (HIR), (University)
  • Effect of des-asp-angiotensin I and angiotensin 1- 7 treatment on the cardiovascular function and angiotensin receptors in the hypertensive rat model, Principal Investigator(PI), 2012 - 2014, Postgraduate Research Grant(PPP), (National)
  • Mechanisms Of The Cardiovascular Therapeutic Potentials Of Boldine And Nitrite In Animal Models Of Diabetes Mellitus And Hypertension., Consultant, 2012 - 2016, High Impact Research - Ministry of Education (HIR-MOE) Cycle 2, (National)
  • Circulating microRNAs as Novel Biomarkers for Early Detection of Atherosclerosis, Co-Investigator, 2011 - 2014, High Impact Research (HIR), (National)
  • Endothelial protective activity of aporphine alkaloids in animals models of diabetes mellitus and hypertension, Principal Investigator(PI), 2011 - 2012, Geran Penyelidikan Universiti Malaya (UMRG), (National)
  • Exploring the Cardio Vascular Mechanism for the Potential Use of Quercetin as Adjuvant to Metformin / Pioglitazone in Management of Type 2 Diabetic Rat Model., Principal Investigator(PI), 2011 - 2013, High Impact Research - University of Malaya (HIR-UM), (National)
  • Effect on Des-Asp-Angiotensin I on improving endothelial dysfunction, Principal Investigator(PI), 2011 - 2011, Fundamental Research Grant Scheme (FRGS), (National)
  • Exploring the cardiovascular mechanisms for the potential use of quercetin as an adjuvant to metformin/pioglitazone in management of type diabetic rat model, Principal Investigator(PI), 2011 - 2013, High Impact Research (HIR), (National)
  • ENDOTHELIAL PROTECTIVE ACTIVITY OF APORPHINE ALKALOIDS IN ANIMALS MODELS OF DIABETES MELLITUS AND HYPERTENSION, Principal Investigator(PI), 2009 - 2011, Geran Penyelidikan Universiti Malaya (UMRG), (National)
  • Effects of WSG 1002, a tetrahydrobiopterin analogue, treatment in an animal model of atherosclerosis, Co-Investigator, 2008 - 2009, Short Term Research Fund (Vote F)(PJP), (National)
  • Effect of chronic treatment of des-Asp- angiotensin I on the cardiovascular function and angiotensin receptors in the Spontaneously Hypertensive rats., Principal Investigator(PI), 2008 - 2009, Postgraduate Research Grant(PPP), (National)
  • Effect of chronic treatment of angiotensin peptides in the development of diabetes in type 2 diabetes mellitus in Goto-Kakizaki rats, Co-Investigator, 2007 - 2009, Fundamental Research Grant Scheme (FRGS), (National)
  • Effect of angiotensin peptides in the renal and mesenteric vasculature of type 1 and type 2- streptozotocin (STZ) induced diabetic rats., Co-Investigator, 2005 - 2007, Short Term Research Fund (Vote F)(PJP), (National)
  • Effect of angiotensin peptides in the renal and mesenteric vasculature of type 1 and type 2 diabetic animal models, Principal Investigator(PI), 2005 - 2006, Postgraduate Research Grant(PPP), (National)
  • Effect of angiotensin peptides in diabetic animals, Principal Investigator(PI), 2004 - 2005, Postgraduate Research Grant(PPP), (National)

CONSULTATION PROJECT/CONSULTANCY
(Project title), (Role), (From)-(Until), (Organisation).


  • Committee member for MSPP_ASVB_VNEM_MSH_2014, 2014-2014, MSPP_ASVB
  • Examiner for candidature defense for Jong Hui Lan, 2011-2011, Department of Pharmacolgy

AWARDS AND RECOGNITIONS
(Name of Award), (Awarding Institution), (Year Awarded), (Level).


  • Certificate of Excellent Service, University Malaya, 2016, (University)
  • Best Oral Presentation (Phd Student Celine Choy Ker Woon)Paeonol Protects Against Endoplasmic Reticulum Stress-Induced Endothelial Dysfunction Via Ampk/Pparδ Signalling Pathway. International Postgraduate Research Awards Seminar (Inpras2016). 7-8th March 2016,University of Malaya, Malaysian Society of Molecular Biology and Biotechnology, 2016, (International)
  • Best Oral Presentation (Phd Student Ling Wei Chih) -Joint Meeting of The 6th Scientific Meeting of The Asian Society for Vascular Biology and The 13th Symposium On Vascular Neuroeffector Mechanisms, Held in Association With The 28th Scientific Meeting of The Malaysian Society of Pharmacology and Physiology in Aug 2014, Asian Vascular Biology Society, 2014, (International)
  • Certificate of Excellent Service, University Malaya, 2012, (University)
  • Best Poster Award (Phd Student), Malaysian Society of Hypertension, 2012, (National)
  • Best Poster Award, Malaysian Society of Pharmacology and Physiology (Mspp), 2008, (National)
  • Recipient of Seawp Travel Award, Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, 2008, (International)
  • Best Oral Award, Malaysian Society of Pharmacology and Physiology (Mspp), 2006, (University)
  • Best Poster Award, Malaysian Society of Pharmacology and Physiology (Mspp), 2005, (National)
  • Best Oral Award, Malaysian Society of Pharmacology and Physiology (Mspp), 2004, (National)
  • Best Poster Award, Malaysian Society of Pharmacology and Physiology (Mspp), 2003, (National)

PRESENTATIONS
(Title), (Event), (Date Presented), (Organiser), (Level).


INVITED SPEAKER
  • Dharmani Devi Murugan. (2016). Targeting Angiogenesis in Osteoarthritis. Combined Meeting of the 46th Malaysian Orthopeadic Association and 10th Asean Arthroplasty Association Meeting. 26th-28th May 2016. Persada Johor International Convention Centre, Johor Bharu, Malaysia., Combined Meeting of the 46th Malaysian Orthopeadic Association and 10th Aseasn Arthroplasty Association Meeting., 2016-05-26 to 2016-05-28, Malaysian Orthopeadic Association, (International)
POSTER
  • Dharmani M, Mustafa MR, Achike FI and Sim MK. Vasomodulatory effect of des-Asp-angiotensin I on the isolated perfused mesentery. , 18th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting., 2003-04-26 to 2003-04-27, UKM, (National)
  • Dharmani M, Mustafa MR, Achike FI and Sim MK. Effects of angiotensin 1-7 on the action of angiotensin II in the isolated perfused kidney of Streptozotocin induced diabetic rats., 20th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting. , 2005-04-25 to 2005-04-26, Malaysian Society of Pharmacology and Physiology , (National)
  • Mustafa MR, Dharmani M, Achike FI, Sim MK. Effects of Angiotensin 1-7 on angiotensin subtypes 1 (AT1) receptor in the renal vasculature of Spontaneously Hypertensive rats. , Life Sciences 2007. 8th -12th July 2007, , 2007-07-08 to 2007-07-12, BJP, (International)
  • Dharmani M, Mustafa MR, Achike FI, Sim MK. Involvement of AT1 angiotensin receptor in the vasomodulatory effect of des-Asp-angiotensin I in the rat renal vasculature., Joint meeting of the Southeast Asian Western Pasific Regional Federation of Pharmacologists and the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists. SEAWP-ASCEPT Proceedings., 2007-12-02 to 2007-12-06, Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, (International)
  • Dharmani M, Mustafa MR, Achike FI, Sim MK. Impaired Vasodepressor action of des-Asp-angiotensin I in the renal vasculature of neonatal-streptozotocin (n-STZ) induced (Type 2) diabetic rat model, 22th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting. , 2008-04-05 to 2008-04-06, Malaysian Society of Pharmacology and Physiology , (National)
  • Song J, Dharmani M, Mustafa MR. (2009). Effects of des-Asp-angiotensin I on vascular reactivity in Goto-Kakizaki (GK) rats. , 23th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting, 2009-05-12 to 2009-05-13, Malaysian Society of Pharmacology and Physiology (MSPP) and UKM, (National)
  • Mohd Rais Mustafa, Dharmani Murugan, Lau Yeh Siang, Khalijah Awang and A.Hamid Hadi. Inhibition of superoxide-anion mediated impairment on endothelial function by treatment of Phoebe Grandis in the isolated rat aorta, 7th COSTAM/SFFR (Asia/Malaysia) international workshop 2009 and the 4th Beinnial Meeting of SFFR Asia, 2009-07-09 to 2009-07-12, (International)
  • Effect of des-Asp-angiotensin I on the vascular functions in the isolated rat aorta of spontaneously hypertensive rats, 24th Scientific Meeting of Malaysian Society of Pharmacology and Physiology, 2010-06-02 to 2010-06-03, Universiti Teknologi Mara, (National)
  • Antioxidant Activity of Boldine prevents endothelial dysfunction in isolated aorta from hypertensive and diabetic rats, 24th Scientific Meeting of the Malaysian Society of Pharmacology and Physiology, 2010-06-02 to 2010-06-03, Universiti Teknologi Mara, (National)
  • Impaired vascular responses to nitrite in hypertensive rat aorta, Experimental Biology 2011, 2011-04-09 to 2011-04-13, (International)
  • Boldine improves endothelial function in aorta of hypertensive rats by enhancing nitric oxide bioavailability and inhibiting NADPH-mediated superoxide production, Malaysian Society of Hypertension 9th Annual Scientific Meeting, 2012-02-10 to 2012-02-12, Malaysian Society of Hypertension, (National)
  • Endothelial protective effects of boldine in type II diabetes. Lau YS, Tian XY, Murugan D, Mustafa MR, Fifth Scientific Meeting Asian Society for Vascular Biology, 2012-10-27 to 2012-10-29, Asian Society for Vascular Biology, (International)
  • Differential mechanisms of vasodilator effect of nitrite in normotensive and hypertensive rat aortas, 11th international symposium on mechanism of vasodilation, 2013-10-04 to 2013-12-06, Zurich Heart Disease and University of Zurich, (International)
  • Exploring the effects of quercetin and metformin combination on the reactivity of aortic tissues from a type 2 diabetic rat model. Thubasni Kunasegaran, Murugan DD, Achike FI, Mustafa MR., Pharmacology and Physiology International Scientific Congress 2014 (MSPP-VNEM-ASVB-MHS 2014), 2014-08-22 to 2014-08-24, MSPP-ASVB-VNEM-MHS, (International)
  • Endothelium dependent relaxation effect of Apocynum venetum leaf extract via Src/PI3K/Akt signaling pathway. Lau YS, Murugan DD, Mustafa MR. , Pharmacology and Physiology International Congress 2014 (MSPP-VNEM-ASVB-MHS 2014), 2014-08-22 to 2014-08-24, MSPP-ASVB-VNEM-MHS, (International)
ORAL
  • Mustafa MR, Dharmani M, NK Kuhneen and Sim MK. Vasomodulatory effects of des-Asp-angiotensin I on the rat isolated perfused kidney. , ASCEPT Proceedings., 2003-12-01 to 2003-12-04, Society of Clinical and Experimental Pharmacologists and Toxicologists Australasian, (International)
  • Dharmani M, Mustafa MR, Achike FI and Sim MK. (2004). Effects of des-Asp-angiotensin I on the action of angiotensin II in the isolated mesenteric vasculature of Streptozotocin induced diabetic rats. , 19th Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting., 2004-05-17 to 2004-05-18, Malaysian Society of Pharmacology and Physiology , (National)
  • Dharmani M, Mustafa MR, Achike FI, Sim MK. Effects of des-Asp-angiotensin I on angiotensin subtypes 1 (AT1) receptor in the renal vasculature of STZ-induced diabetic rats. , Seminar Hasil Penyelidikan Universiti Malaya, 2006-09-06 to 2006-09-07, IPPP, University Malaya, (University)
  • Enfothelium-dependent, eNOS independent relaxation to nitrite in the aorta of the SHR. Ling WC, Murugan DD, Mustafa MR, Vanhoutte PM., Pharmacology and Physiology International Scientific Congress 2014 (MSPP-VNEM-ASVB-MHS 2014), 2014-08-22 to 2014-08-24, MSPP-ASVB-VNEM-MHS, (International)
  • Des-Asp-Angiotensin I inhibits Angiotensin II induced vasoconstriction and oxidative stress in SHR. Loh WM, Ling WC, Murugan DD, Vanhoutte PM, Lau YS, Achike FI, Mustafa MR., International Postgraduate Research Awards Seminar, 2014-12-10 to 2014-12-11, University of Malaya, (National)
OTHERS
  • Boldine treatment improves endothelial dysfunction in streptozotocin-induced diabetes, International Symposium on Vascular Biology 2012, 2012-03-24 to 2012-03-24, Vascular biology Research Group, CMU, (International)
  • Ker Woon Choy, Yeh Siang Lau, Dharmani Murugan, Mohd Rais Mustafa. (2017). Paeonol Attenuates Lipopolysaccharide induced Apoptosis In Human Umbilical Vein Endothelial Cells By Inhibiting BMP4/ROS/MAPK Signaling. 31st Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting. 18th 19th August 2017. Universiti Sains Malaysia, Kelantan, 31st Malaysian Society of Pharmacology and Physiology (MSPP) Scientific Meeting., 2017-08-18 to 2017-08-19, Malaysian Society of Pharmacology and Physiology (MSPP) , (National)

EXPERT LINKAGES
(Linkages Description), (Organisation), (Year of Involvement), (Duration), (Level).


  • Research collaboration: Asooc. Prof. Dr. Suresh Kumar, University of Nottingham Malaysia Campus, 2014, 24, (National)
  • Research collaboration: Prof. Francis Achike, College of Medicine, Central Michigan University, 2013, 36, (International)
  • Research collaboration: Prof. Paul Vanhoutte, University of Hong Kong, 2012, 48, (International)
  • Research collaboration : Prof. Huang Yu, Chinese University of Hong Kong, 2012, 48, (International)

EXPERT/TECHNICAL CONTRIBUTIONS
(Activity), (Organisation), (Role), (From)-(Until), (Level).


  • Organizing committee for 2nd International Conference of Molecular Biology and Biology, Malaysian Society of Molecular Biology and Biotechnology, Committee Member, 2017-2017, (International)
  • Prescription skills workshop, MerDU and FOM, Resource Person, 2016-2017, (University)
  • Invited symposium speaker in Faculty of Medicine Research Week 2015, Department of Pharmacology and Pharmacy, FOM, Resource Person, 2015-2015, (University)
  • Faculty of Medicine Research Week 2015, Department of Pharmacology and Pharmacy, FOM, Committee Member, 2015-2015, (University)
  • Prescription skills workshop, FOM, University of Malaya, Expert Advisor, 2014-2015, (University)
  • Assesment and accreditation of laboratory animal care international (AAALAC), University Malaya and AAALAC, Coordinator, 2014-2015, (University)

EVALUATION ACTIVITIES
(Description), (Evaluation Activity),(Year).


  • External Examiner for Masters thesis Lsilvia Si Yiang Nee (UKM), Thesis ,  (2017 - 2017)
  • Review article for BMC Pharmacology and Toxicology, Article In Journal ,  (2016)
  • Review article for Journal of Asian Natural Products Research, Article In Journal ,  (2016)
  • Evaluation of anti-ulcer and antioxidant activity of 2-nitro-N'-phenylbenzohydrazide in rats. MBEB 4180 Research Project in Biomedical Science (2015 - 2016), Thesis ,  (2016)
  • Evaluate an scientific article for JUMMEC, Article In Journal ,  (2015 - 2015)
  • Undergraduate thesis entitled Immunological and functional studies on the neutralisation of medically important pit viper venoms, Thesis ,  (2015 - 2015)
  • Reviewed an article for Cardiovascular and Experimental Pharmacology and Physiology Journal (CEPP), Article In Journal ,  (2015 - 2015)
  • External examiner for an undergradute thesis for yberjaya university- subacte and acute toxicological study on supplementation of high dose of evening primrose oil in rats, Thesis ,  (2013 - 2013)
  • evaluation of dopamine and serotonin receptor binding activity of selected aporphines- vani munusamy MGN090016, Thesis ,  (2012 - 2012)
  • Association of uridine diphospho glucuronosyltransferase 1 family polypeptide A6 (UGT1A6) gene polymorphism and responsiveness to sodium valproate in epilepsy patients in Malaysia - Rayinda Rahmadhani ( MTEB2180) 2008/2009, Thesis ,  (2009 - 2009)
  • Association of FABP2 A54T polymorphism with soium valproate responsiveness in malaysian epilepsy patients- Norhidayah bt mohammad noor (MTEB2180) 2008/2009, Thesis ,  (2008 - 2008)

CONTRIBUTION TO SOCIETY
(Contribution To Society), (Level), (Start Date), (End Date).


  • Facilitator for Let's go to Mummies Lab , (Community), 13/02/2018 until 13/02/2018

SUPERVISION


POST GRADUATE STUDENT
(Name of Degree), (Name of Candidates), (Title of Thesis), (Academic Session)

Completed
  • Doctoral Degree (phd), Ling Wei Chih, Modulation of Endothelial Function by Sodium Nitrite: Therapeutic Implications for Hypertension., 2016/2017
  • Master Degree, Thubasni Kunasegaran, Quercetin Synergizes with Pioglitazone, a PPAR Gamma Agonist, in Improving Endothelial Dysfunction in Diabetic Rat Model., 2015/2016
  • Master Degree, Loh Wei Mee, Modulatory actions of Des-Aspartate-Angiotensin I on vascular reactivity and endothelial function in aorta from spontaneously hypertensive rats., 2014/2015
  • Doctoral Degree (phd), Ling Wei Chih, Sensitization of endogenous and exogenous nitrite in hypertension, 2014/2015
  • Master Degree, Thubasni Kunasegaran, Quercetin Synergizes with Pioglitazone, a PPAR Gamma Agonist, in Improving Endothelial Dysfunction in Diabetic Rat Model., 2013/2014
  • Doctoral Degree (phd), Lau Yeh Siang, ENDOTHELIAL PROTECTIVE ACTIVITY OF BOLDINE IN ANIMAL MODELS OF HYPERTENSION AND DIABETES MELLITUS, 2012/2013
  • Doctoral Degree (phd), Lau Yeh Siang, ENDOTHELIAL PROTECTIVE ACTIVITY OF BOLDINE IN ANIMAL MODELS OF HYPERTENSION AND DIABETES MELLITUS, 2010/2011
  • Master Degree, Loh Wei Mee, Modulatory actions of Des-Aspartate-Angiotensin I on vascular reactivity and endothelial function in aorta from spontaneously hypertensive rats., 2010/2011

Ongoing
  • Doctoral Degree (phd), Choy Ker Woon, PHARMACOLOGICAL EFFECTS OF PAEONOL AGAINST ENDOPLASMIC RETICULUM STRESS AND INFLAMMATION-INDUCED ENDOTHELIAL DYSFUNCTION, 2017/2018
  • Master Degree, Dharvind A/l Balan, In vitro and in vivo anti-adipogenic effects of a standardized quassinoids composition from Eurycoma longifolia., 2017/2018
  • Doctoral Degree (phd), Manizheh Khalilpourfarshbafi, Study to Elucidate the Molecular Mechanisms Underlying the Anti-Adipogenic Effect of Withaferin A., 2017/2018
  • Doctoral Degree (phd), Manizheh Khalilpourfarshbafi, Study to Elucidate the Molecular Mechanisms Underlying the Anti-Adipogenic Effect of Withaferin A., 2015/2016
  • Master Degree, Dharvind A/l Balan, ANTI-ADIPOGENIC AND ENERGY MODULATION MECHANISMS OF QUASSINOIDS FROM EURYCOMA LONGIFOLIA, 2015/2016
  • Doctoral Degree (phd), Chor Key Woon, THE EFFECTS OF PAEONOL AGAINST ENDOTHELIAL DYSFUNCTION IN INFLAMMATION & HYPERTENSION, 2014/2015
  • Master Degree, Lau Yeh Siang, -, 2010/2011

TEACHING
(Course Title), (Academic Session), (No of Student), (No of Contact Hours).


FIRST DEGREE
  • , 120, 2
  • PHARMACOLOGY, 2018/2019(1), 60, 4
  • PBL Stage 1 and 2, 2018/2019, 8, 15
  • PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2018/2019(1), 48, 10
  • UMMP , 2018/2019, 120, 7
  • PBL Stage 1 and 2, 2017/2018, 8, 16.5
  • PHARMACOLOGY IN NURSING, 2017/2018(2), 25, 2
  • ADVANCES IN MEDICAL PHARMACOLOGY, 2017/2018(2), 40, 9
  • PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2017/2018, 45, 12
  • DRUG ACTION AND DISCOVERY, 2017/2018(2), 45, 9
  • PHARMACOLOGY, 2017/2018, 48, 7
  • PHARMACOLOGY AND HANDLING OF MEDICATION, 2016/2017(1), 16, 2
  • PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2016/2017(1), 36, 9
  • CENTRAL NERVOUS SYSTEM & THERAPY, 2016/2017, 5, 7
  • , 2016/2017, 120, 18
  • , 2016/2017, 120, 16
  • PHARMACOLOGY, 2016/2017(1), 68, 6
  • PHARMACOTHERAPY FOR GASTROINTESTINAL AND RESPIRATORY DISORDERS, 2016/2017, 30, 8
  • PHARMACOLOGY AND HANDLING OF MEDICATION, 2015/2016(2), 12, 2
  • Farmakologi for MBBS, 2015/2016(1,2), 120, 4
  • GENERAL PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2015/2016(1,2), 44, 13
  • FARMAKOLOGI, 2015/2016(1,2), 70, 15
  • FARMAKOLOGI, 2015/2016(2), 68, 3
  • PBL for MBBS, 2015/2016(1,2), 8, 9
  • Pharmacology, 2014/2015, 200, 38
  • ADVANCED MEDICAL PHARMACOLOGY, 2014/2015, 5, 9
  • PHARMACOLOGY AND HANDLING OF MEDICATION, 2014/2015(2), 20, 2
  • FARMAKOLOGI, 2013/2014(1), 68, 10
  • CENTRAL NERVOUS SYSTEM & THERAPY, 2013/2014(1), 60, 7
  • Phase II -Pharmacology, 2013/2014, 160, 18
  • GENERAL PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2013/2014(1), 30, 10
  • nursing, 2013/2014, 10, 2
  • Phase II -Pharmacology, 2012/2013, 180, 20
  • FARMAKOLOGI, 2012/2013(2), 70, 4
  • PRINCIPLES OF DRUG ACTION & PERIPHERAL NERVOUS SYSTEM, 2012/2013(2), 60, 6
  • CENTRAL NERVOUS SYSTEM & THERAPY, 2010/2011(1), 60, 7
  • ADVANCED MEDICAL PHARMACOLOGY, 2010/2011(2), 13, 12
  • Phase II -Pharmacology, 2010/2011(1,2), 200, 31
  • GENERAL PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2010/2011(1), 53, 12
  • FARMAKOLOGI, 2010/2011(1,2), 84, 12