ARTICLE IN ACADEMIC JOURNALS
| NO | DETAILS OF ARTICLE IN ACADEMIC JOURNALS |
|---|---|
| 1. |
Investigation of cytotoxic indoleninyl-thiobarbiturate zwitterions as DNA targeting agents
2025
Author(s) : Sim Kae Shin Source :
Journal of Molecular Structure
|
| 2. |
Sialic Acid Detection and Theranostic Activity of Phenylboronic Acid-based Fluorescent Probe in Human Colorectal Adenocarcinoma HT-29 Cells
2025
Author(s) : Sim Kae Shin Source :
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
DOI :
10.1016/j.saa.2024.125116
|
| 3. |
Structural and Functional Characterization of Gamma-Irradiation-Enhanced Nanocomposites for Colorectal Cancer Therapy
2025
Author(s) : Sim Kae Shin, Hazwani Mat Saad Source :
Journal of Molecular Structure
|
| 4. |
In Vitro and Computational Studies of Indoleninyl-Pyrimido[1,2-b]Indazoles as DNA Binding Agents
2024
Author(s) : Sim Kae Shin Source :
NATIONAL ACADEMY SCIENCE LETTERS-INDIA
|
| 5. |
nvestigation of Phytochemical Composition, Radical Scavenging Potential, Anti-Obesogenic Effects, and Anti-Diabetic Activities of Kaempferia parviflora Rhizomes
2024
Author(s) : Sim Kae Shin Source :
CHEMISTRY & BIODIVERSITY
|
| 6. |
Antimicrobial and Antiproliferative Effects of Zingiberaceae Oils: A Natural Solution for Oral Health
2024
Author(s) : Sim Kae Shin Source :
CHEMISTRY & BIODIVERSITY
DOI :
10.1002/cbdv.202301836
|
| 7. |
Computational and In vitro Elucidation of Indolenine-barbituric Acid Zwitterions as Potential Chemotherapeutical Agents
2024
Author(s) : Sim Kae Shin Source :
Letters in Drug Design & Discovery
DOI :
10.2174/0115701808279494231206060106
|
| 8. |
Quinoline, Indole, and Isogranatanine Alkaloids from Malayan Leuconotis eugeniifolia
2024
Author(s) : Sim Kae Shin Source :
JOURNAL OF NATURAL PRODUCTS
DOI :
10.1021/acs.jnatprod.3c00960
|
| 9. |
Discovery of indoleninyl-pyrazolo[3,4-b]pyridines as potent chemotherapeutic agents against colorectal cancer cells
2024
Author(s) : Sim Kae Shin Source :
BIOORGANIC CHEMISTRY
DOI :
https://doi.org/10.1016/j.bioorg.2024.107256
|
| 10. |
Development and Characterization of Tannic Acid-Modified PVA-κCarrageenan Gel for Sustained Release of Lidocaine
2024
Author(s) : Sim Kae Shin, Hazwani Mat Saad Source :
ChemistrySelect
|
| 11. |
A new cinnamaldehyde-rhodamine based dual chemosensor for Cu2+ and Fe3+ and its applicability in live cell imaging
2023
Author(s) : Sim Kae Shin Source :
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
|
| 12. |
Polyneurines A-H, iboga alkaloids from Tabernaemontana polyneura
2023
Author(s) : Sim Kae Shin Source :
PHYTOCHEMISTRY
|
| 13. |
A new lipophilic cationic rhodamine-based chemosensor for detection of Al(III)/Cu(II) and intracellular pH change and its application as a smartphone-assisted sensor in water sample analysis
2023
Author(s) : Sim Kae Shin Source :
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
|
| 14. |
Artocarpus heterophyllus Lam. stem bark inhibits melanogenesis through regulation of ROS, cAMP, and MAPK pathways
2023
Author(s) : Sim Kae Shin, Hazwani Mat Saad Source :
Sains Malaysiana
|
| 15. |
Chippiine, iboga, cleavamine, vobasine, and cytotoxic bisindole alkaloids from Tabernaemontana polyneura
2023
Author(s) : Sim Kae Shin Source :
TETRAHEDRON
DOI :
https://doi.org/10.1016/j.tet.2023.133706
|
| 16. |
From lab to life: Safe and efficient optical based dual-mode chemosensor for the detection of aluminium (III) and copper (II) ions
2023
Author(s) : Sim Kae Shin Source :
INORGANICA CHIMICA ACTA
DOI :
https://doi.org/10.1016/j.ica.2023.121703
|
| 17. |
Structural insights and cytotoxicity evaluation of benz[e]indole pyrazolyl-substituted amides
2023
Author(s) : Sim Kae Shin Source :
MOLECULAR DIVERSITY
|
| 18. |
A rapid turn-on dual functional rhodamine B probe for aluminum (III) and copper (II) that can be utilised as a molecular logic gate and in water analysis
2022
Author(s) : Sim Kae Shin Source :
JOURNAL OF MOLECULAR STRUCTURE
|
| 19. |
Iohexol functionalized Si-Ag:Mn3O4 hybrid nanoparticles based contrast agent for computed tomography imaging
2022
Author(s) : Sim Kae Shin Source :
Materials Today Communications
|
| 20. |
Group 6 photo-activable carbon monoxide-releasing molecules (PhotoCORMs) with 1’10-phenanthroline based ligand as potential anti-proliferative and anti-microbial agents
2022
Author(s) : Sim Kae Shin Source :
INORGANICA CHIMICA ACTA
|
| 21. |
Synthesis, characterisation and biological activity of diorganotin compounds of (E)-N’-(5-nitro-2-hydroxybenzylidene)-3-hydroxy-2-naphthohydrazide
2022
Author(s) : Sim Kae Shin Source :
POLYHEDRON
|
| 22. |
Surgical site infection and development of antimicrobial sutures: a review
2022
Source :
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
|
| 23. |
Neuroprotective properties of wild medicinal mushroom, Sanguinoderma rugosum (Agaricomycetes) extracts against glutamate-induced hippocampal cells
2022
Author(s) : Sim Kae Shin Source :
INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS
|
| 24. |
Antiproliferative and microtubule-stabilizing activities of two iboga-vobasine bisindoles alkaloids from Tabernaemontana corymbosa in colorectal adenocarcinoma HT-29 cells
2022
Author(s) : Sim Kae Shin, Taznim Begam Binti Mohd Mohidin Source :
PLANTA MEDICA
|
| 25. |
Evaluation of Antioxidant activity and Phytochemical Composition of Baeckea frutescens and Leptospermum javanicum Essential Oils.
2021
Source :
SOUTH AFRICAN JOURNAL OF BOTANY
|
| 26. |
The bisindole alkaloids Angustilongines M and A from Alstonia penangiana induce mitochondrial apoptosis and G0/G1 cell cycle arrest in HT-29 cells through promotion of tubulin polymerization
2021
Source :
JOURNAL OF NATURAL PRODUCTS
|
| 27. |
From one to three, modifications of sensing behavior with solvent system: DFT calculations and real-life application in detection of multianalytes (Cu2+, Ni2+ and Co2+) based on a colorimetric Schiff base probe
2021
Source :
Journal of Molecular Structure
|
| 28. |
Evaluation of anti-melanogenesis and free radical scavenging activities of five Artocarpus species for cosmeceutical applications
2021
Author(s) : Sim Kae Shin Source :
Industrial Crops and Products
|
| 29. |
Interactive effects of warming and copper toxicity on a tropical freshwater green microalga Chloromonas augustae (Chlorophyceae)
2021
Author(s) : Sim Kae Shin Source :
Journal of Applied Phycology
|
| 30. |
Arbolodinines A-C, biologically-active aspidofractinineaspidofractinine, aspidofractinine-strychnan, and kopsine-strychnan bisindole alkaloids from Kopsia arborea
2021
Author(s) : Sim Kae Shin Source :
Tetrahedron
|
| 31. |
Synthesis of phenanthroline-based ligand and its UV activable tetracarbonyl photoCORMs based on chromium, molybdenum, and tungsten as cytotoxic and antimicrobial agents
2021
Author(s) : Sim Kae Shin, Tan Kong Wai Source :
Journal of Organometallic Chemistry
|
| 32. |
Synthesis of group 6 (chromium, molybdenum, and tungsten) photoCORMs as potential antimicrobial and anticancer agents
2021
Author(s) : Sim Kae Shin, Tan Kong Wai Source :
Inorganica Chimica Acta
|
| 33. |
A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity.
2021
Source :
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
|
| 34. |
Nickel(II) complexes with polyhydroxybenzaldehyde and O,N,S tridentate thiosemicarbazone ligands: synthesis, cytotoxicity, antimalarial activity, and molecular docking studies
2021
Author(s) : Sim Kae Shin Source :
Journal of Molecular Structure
|
| 35. |
A turn on fluorescent sensor for detecting Al3+ and colorimetric detection for Cu2+: Synthesis, cytotoxicity and on-site assay kit.
2021
Author(s) : Sim Kae Shin Source :
Journal of Photochemistry & Photobiology, A: Chemistry
|
| 36. |
Specific detection of Cu2+ by a pH-independent colorimetric rhodamine based chemosensor
2021
Source :
Optical Materials
|
| 37. |
Nickel and zinc complexes of testosterone N4-substituted thiosemicarbazone: Selective cytotoxicity towards human colorectal carcinoma cell line HCT 116 and their cell death mechanisms
2020
Author(s) : Sim Kae Shin, Tan Kong Wai Source :
Journal of Inorganic Biochemistry
|
| 38. |
Mitochondria-dependent apoptosis inducer: Testosterone-N4-ethylthiosemicarbazonate and its metal complexes with selective cytotoxicity towards human colorectal carcinoma cell line (HCT 116)
2020
Author(s) : Sim Kae Shin, Tan Kong Wai Source :
Inorganica Chimica Acta
|
| 39. |
Cytotoxic and anticancer properties of the Malaysian mangrove pit viper (Trimeresurus purpureomaculatus) venom and its disintegrin (purpureomaculin)
2020
Author(s) : Sim Kae Shin Source :
Journal of Venomous Animals and Toxins including Tropical Diseases
|
| 40. |
Evaluation of DNA binding and topoisomerase I inhibitory activities of 16′‐decarbomethoxydihydrovoacamine from Tabernaemontana corymbose
2020
Author(s) : Sim Kae Shin Source :
ChemistrySelect
|
| 41. |
Synthesis, Cytotoxicity and Antimalarial Activities of Thiosemicarbazones and their Nickel (II) complexes
2020
Author(s) : Sim Kae Shin, Tan Kong Wai Source :
Journal of Molecular Structure
|
| 42. |
Conolodinines A−D, Aspidosperma−Aspidosperma Bisindole Alkaloids with Antiproliferative Activity from Tabernaemontana
corymbosa
2019
Author(s) : Sim Kae Shin Source :
Journal of Natural Products
|
| 43. |
Macroline Sarpagine bisindole alkaloids with antiproliferative activity from Alstonia penangiana
2019
Author(s) : Sim Kae Shin Source :
Journal of Natural Products
DOI :
10.1021/acs.jnatprod.9b00712.
|
| 44. |
Synthesis, structural characterization, cytotoxicity and encapsulation studies of N,Nʹ-(1,2-dicyano-1,2-vinylene)-bis(4-hydroxysalicylideneaminato)di(p-chlorobenzyl)tin as potential anticancer drug.
2019
Author(s) : Sim Kae Shin Source :
Main Group Metal Chemistry
|
| 45. |
A Cytotoxic Indole Characterized by Incorporation of a Unique Carbon−Nitrogen Skeleton and Two Pentacyclic Corynanthean Alkaloids Incorporating a Substituted Tetrahydrofuranone Ring from Kopsia arborea
2019
Author(s) : Lim Siew Huah, Sim Kae Shin Source :
Journal of Natural Products
|
| 46. |
Metabolic and physiological regulation of Chlorella sp. (Trebouxiophyceae, Chlorophyta) under nitrogen deprivation
2019
Author(s) : Nazia Binti Abdul Majid, Sim Kae Shin Source :
JOURNAL OF OCEANOLOGY AND LIMNOLOGY
|
| 47. |
Physiological and metabolic responses of Scenedesmus quadricauda (Chlorophyceae) to nickel toxicity and warming.
2019
Author(s) : Sim Kae Shin, Lim Phaik Eem Source :
3 Biotech
|
| 48. |
Antimelanogenesis and anti-inflammatory activity of selected culinary-medicinal mushroom
2018
Author(s) : Sim Kae Shin Source :
International Journal of Medicinal Mushrooms
|
| 49. |
Size-dependent effect of cystine/citric acid-capped confeito-like gold nanoparticles on cellular uptake and photothermal cancer therapy
2018
Author(s) : Sim Kae Shin Source :
Colloids and Surfaces B: Biointerfaces
|
| 50. |
Ajmaline, oxindole, and cytotoxic macroline akuammiline bisindole alkaloids from Alstonia penangiana
2018
Source :
Journal of natural Products
|
| 51. |
Caffeoylquinic acids induce cell death and cell cycle arrest on HCT 116 cells via formation of extracellular H2O2 and oxidation products
2018
Author(s) : Sim Kae Shin Source :
Chiang Mai Journal of Science
|
| 52. |
Interactive effects of temperature and copper toxicity on photosynthetic efficiency and metabolic plasticity in Scenedesmus quadricauda (Chlorophyceae)
2018
Author(s) : Sim Kae Shin Source :
JOURNAL OF APPLIED PHYCOLOGY
|
| 53. |
Intrinsic capabilities of Leptospermum javanicum in inducing apoptosis and suppressing the metastatic potential of human lung carcinoma cells
2017
Author(s) : Sim Kae Shin Source :
Chemico-Biological Interactions
|
| 54. |
Anti-proliferation effect of Guanosine on HCT 116 cells involves MAPK and AMPK pathways
2017
Author(s) : Sim Kae Shin Source :
Nucleosides, Nucleotides and Nucleic Acids
|
| 55. |
Structural and cytotoxic studies of cationic thiosemicarbazones
2017
Author(s) : Sim Kae Shin Source :
Journal of Molecular Structure
|
| 56. |
Cationic Schiff base derivative induces In vitro apoptosis in metastatic PC-3 cells via activation of mitochondrial pathway
2017
Author(s) : Sim Kae Shin Source :
Anti-Cancer Agents in Medicinal Chemistry
|
| 57. |
Phytochemical investigation of Gynura bicolor leaves and cytotoxicity evaluation of the chemical constituents against HCT 116 cells
2016
Author(s) : Sim Kae Shin Source :
Natural Product Research
|
| 58. |
Vobatensines A F, Cytotoxic Iboga-Vobasine Bisindoles from Tabernaemontana corymbosa
2016
Author(s) : Sim Kae Shin Source :
Journal of Natural Products
|
| 59. |
Evaluation of antioxidant properties, cytotoxicity and acute oral toxicity of Gynura procumbens (Compositae)
2016
Author(s) : Sim Kae Shin Source :
Sains Malaysiana
|
| 60. |
Fistulopsines A and B antiproliferative septicine-type alkaloids from Ficus fistulosa
2016
Author(s) : Sim Kae Shin Source :
Phytochemistry Letters
|
| 61. |
A new oxolane from Enterobacter cloacae
2016
Author(s) : Sim Kae Shin Source :
Natural Product Research
|
| 62. |
A Hexacyclic, Iboga-Derived Monoterpenoid Indole with a Contracted Tetrahydroazepine C Ring and Incorporation of an Isoxazolidine Moiety, a Seco-Corynanthean, an Aspidosperma- Aspidosperma Bisindole with Anticancer Properties, and the Absolute Configuration of the Pyridopyrimidine Indole Alkaloid, Vernavosine
2016
Author(s) : Sim Kae Shin Source :
Journal of Natural Products
|
| 63. |
Aspidofractinine and Eburnane Alkaloids from a North Borneo Kopsia. Ring-Contracted, Additional Ring-Fused, and PaucidactineType Aspidofractinine Alkaloids from K. pauciflora
2016
Author(s) : Sim Kae Shin Source :
Journal of Natural Products
|
| 64. |
Leptospermum flavescens constituent-LF1 causes cell death through the induction of cell cycle arrest and apoptosis in human lung carcinoma cells
2015
Author(s) : Sim Kae Shin Source :
PLoS ONE
|
| 65. |
Biologically active vallesamine, strychnan, and rhazinilam alkaloids from Alstonia: Pneumatophorine, a nor-secovallesamine with unusual incorporation of a 3-ethylpyridine moiety
2015
Author(s) : Sim Kae Shin Source :
Phytochemistry
|
| 66. |
Synthesis of a DNA-targeting nickel (II) complex with testosterone thiosemicarbazone which exhibits selective cytotoxicity towards human prostate cancer cells (LNCaP)
2015
Source :
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
|
| 67. |
Evaluation of selected biological capacities of Baeckea frutescens
2015
Author(s) : Sim Kae Shin, Sugumaran A/l Manickam Source :
BMC Complementary and Alternative Medicine
|
| 68. |
Synthesis, characterization and biological studies of diorganotin(IV) complexes with tris[(hydroxymethyl)aminomethane] Schiff bases.
2015
Source :
Inorganica Chimica Acta
|
| 69. |
A new oxathiolane from Enterobacter cloacae. Natural Product Research, 29 (8): 722-726.
2015
Source :
Natural Product Research
DOI :
10.1080/14786419.2014.983507
|
| 70. |
Cytotoxic Activity of Alpinia murdochii Ridl.:A Mountain Ginger Species from Peninsular Malaysia
2014
Source :
Pharmacognosy Magazine
|
| 71. |
Oxidized Derivatives of Macroline, Sarpagine, and Pleiocarpamine Alkaloids from Alstonia angustifolia
2014
Author(s) : Sim Kae Shin Source :
Journal of Natural Products
|
| 72. |
Cytotoxic Vobasine, Tacaman, and Corynanthe- Tryptamine Bisindole Alkaloids from Tabernaemontana and structure revision of Tronoharine
2014
Author(s) : Sim Kae Shin Source :
Journal of Natural Products
|
| 73. |
Copper complexes with phosphonium containing hydrazone ligand: Topoisomerase inhibition and cytotoxicity study
2014
Author(s) : Sim Kae Shin Source :
European Journal of Medicinal Chemistry
|
| 74. |
Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora
2014
Author(s) : Sim Kae Shin Source :
Phytochemistry
|
| 75. |
Synthesis, characterization and biological evaluation of cationic hydrazone copper complexes with diverse co-ligands
2014
Author(s) : Sim Kae Shin Source :
RSC Advances
|
| 76. |
Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia macrophylla
2014
|
| 77. |
Antioxidant capacity, cytotoxicity, and acute oral toxicity of Gynura bicolor
2013
Author(s) : Sim Kae Shin, Norhanom Binti Abdul Wahab |
| 78. |
Synthesis, characterization and biological activity of diorganotin complexes with ONO terdentate Schiff base.
2013
Author(s) : Sri Nurestri Binti Hj Abd Malek, Lee See Mun, Lo Kong Mun, Hapipah Binti Mohd Ali, Sim Kae Shin Source :
Inorganica Chimica Acta
|
| 79. |
Cytotoxic effect of Alpinia scabra (Blume) Naves extracts on human breast and ovarian cancer cells
2013
Source :
BMC Complementary and Alternative Medicine
|
| 80. |
Phenolic content, antioxidant effect and cytotoxic activity of Leea indica leaves
2012
Author(s) : Norhanom Binti Abdul Wahab, Sim Kae Shin Source :
BMC Complementary and Alternative Medicine
|
| 81. |
Synthesis, structural characterization and in vitro cytotoxicity of diorganotin complexes with schiff base ligands derived from 3- hydroxy-2- naphthoylhydrazide
2012
Author(s) : Lo Kong Mun, Hapipah Binti Mohd Ali, Sri Nurestri Binti Hj Abd Malek, Lee See Mun, Sim Kae Shin Source :
APPLIED ORGANOMETALLIC CHEMISTRY
|
| 82. |
Phytochemical and Cytotoxic Investigations of Alpinia mutica Rhizomes
2011
Source :
Molecules
|
| 83. |
[3-({(E)-2-[(4-Fluorophenyl)carbamothioyl] hydrazinylidene}methyl)-4-hydroxybenzyl] methyltriphenylphosphonium chloride
2011
Author(s) : Sim Kae Shin |
| 84. |
Phenolic content and antioxidant activity of crude and fractionated extracts of Pereskia bleo (Kunth) DC. (Cactaceae)
2010
Author(s) : Sim Kae Shin |
| 85. |
Phenolic content and antioxidant activity of Pereskia grandifolia Haw. (Cactaceae) extracts
2010
Author(s) : Sim Kae Shin |
| 86. |
Acute oral toxicity of Pereskia bleo and Pereskia grandifolia in mice
2010
Source :
Pharmacognosy Magazine
|
| 87. |
Cytotoxic activity of leaf and rhizome extracts of Alpinia scabra (Blume) N ves, a wild ginger from Peninsular Malaysia
2010
Author(s) : Sim Kae Shin Source :
African Journal of Pharmacy and Pharmacology
|
| 88. |
Phytochemical and cytotoxic investigations of Pereskia grandifolia Haw. (Cactaceae) leaves
2009
Author(s) : Sim Kae Shin |
| 89. |
Cytotoxic components of Pereskia bleo (Kunth) DC. (Cactaceae) leaves
2009
Author(s) : Sim Kae Shin |
| 90. |
Antimicrobial Activity of some Medicinal plants from Malaysia Malaysia
2009
Author(s) : Sri Nurestri Binti Hj Abd Malek, Sim Kae Shin Source :
American J. Applied Sciences
|
| 91. |
Cytotoxic activity of Pereskia bleo (Cactaceae) against selected human cell lines
2008
Author(s) : Sim Kae Shin |
RESEARCH PROJECT
| GRANT | PROGRESS | STATUS |
|---|---|---|
|
Biological Studies Of Synthetic Compounds (bisbenzopyrans, Bisbenzofurans, Oxocines, And Structural Analogs) And Natural Compounds (indole And Bisindole Derivatives) For Reversal Of Multidrug Resistance And Antiproliferative Activity Against Human Cancer Cells
Researcher(s) : Prof. Dr. Kam Toh Seok, Dr. Lim Siew Huah |
|
end |
|
Metabolic Response Of Marine Microalgae From Different Latitudes Towards Temperature Stress
Researcher(s) : Prof. Dr. Lim Phaik Eem |
|
end |
RESEARCH COLLABORATOR
| GRANT | PROGRESS | STATUS |
|---|---|---|
|
Mechanistic Insight Into Potential Neuroprotective Candidate, Malaysian Mushroom Amauroderma Rugosum (cendawan Budak Sawan) Against Epileptogenesis In In Vitro: A Cross-talk Between Glia And Neurons
|
|
end |
|
Multi-targeted Therapy Of Malaria By Metal Chelators And Complexes
Researcher(s) : Associate Prof. Dr. Sim Kae Shin |
|
end |
|
Synthesis Of Titanocenedi(aminoacid) Salts For Evaluation Of Antitumor Activity
Researcher(s) : Associate Prof. Dr. Sim Kae Shin |
|
end |
|
Alkaloid Variation In Malaysian Alstonia: Determination Of Variation Of Alkaloid Composition In A. Macrophylla As A Function Of Location
Researcher(s) : Associate Prof. Dr. Sim Kae Shin |
|
end |