ARTICLE IN ACADEMIC JOURNALS
| NO | DETAILS OF ARTICLE IN ACADEMIC JOURNALS |
|---|---|
| 1. |
Autophagy is deregulated in cancer-associated fibroblasts from oral cancer and is stimulated during the induction of fibroblast senescence by TGF- 1.
2021
Author(s) : Ian Charles Paterson Source : Scientific Reports |
| 2. |
Myofibroblast transdifferentiation is associated with changes in cellular and extracellular ves.icle miRNA abundance
2021
Source : PLOS ONE |
| 3. |
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF- B activation and immune escape.
2021
Author(s) : Ian Charles Paterson,Yap Lee Fah Source : NATURE COMMUNICATIONS |
| 4. |
3D Clumps/Extracellular Matrix Complexes of Periodontal Ligament Stem Cells Ameliorate the Attenuating Effects of LPS on Proliferation and Osteogenic Potential.
2021
Source : JOURNAL OF PERSONALIZED MEDICINE |
| 5. |
P2Y purinergic receptor signaling in oral squamous cell carcinoma cell lines and its role in proliferation and cisplatin-mediated apoptosis.
2021
Author(s) : Ian Charles Paterson Source : Sains Malaysiana |
| 6. |
Establishing a technique for isolation and characterization of human periodontal ligament derived mesenchymal stem cells.
2021
Author(s) : Ian Charles Paterson Source : SAUDI DENTAL JOURNAL |
| 7. |
The development of a novel transforming growth factor- (TGF- ) inhibitor that disrupts ligand-receptor interactions.
2020
Author(s) : Ian Charles Paterson Source : Eur J Med Chem |
| 8. |
Development of small molecule inhibitors targeting TGF-β ligand and receptor: Structures, mechanism, preclinical studies and clinical usage.
2020
Author(s) : Ian Charles Paterson Source : European Journal of Medicinal Chemistry |
| 9. |
Deregulation of lysophosphatidic acid metabolism in oral cancer promotes cell migration via the up-regulation of COX-2.
2020
Author(s) : Chai Wen Lin,Ian Charles Paterson Source : Peer J DOI : 10.7717/peerj.10328 |
| 10. |
Profiling lysophosphatidic acid levels in plasma from head and neck cancer patients.
2020
Source : Peer J DOI : 10.7717/peerj.9304 |
| 11. |
Monoamine oxidase A is downregulated in EBV-associated nasopharyngeal carcinoma.
2020
Author(s) : Ian Charles Paterson Source : Scientific Reports |
| 12. |
Collagen induces a more proliferative, migratory and chemoresistant phenotype in head and neck cancer via DDR1.
2019
Author(s) : Ian Charles Paterson,Anand Ramanathan Source : Cancers |
| 13. |
Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks.
2019
Source : BMC GENOMICS |
| 14. |
Cisplatin-Resistance in Oral Squamous Cell Carcinoma: Regulation by Tumor Cell-Derived Extracellular Vesicles.
2019
Author(s) : Ian Charles Paterson Source : Cancers |
| 15. |
In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and 1 receptors.
2019
Author(s) : Ian Charles Paterson Source : chemical biology and drug design |
| 16. |
Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and 1 receptor antagonists.
2018
Author(s) : Ian Charles Paterson Source : MedChemComm |
| 17. |
Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection.
2018
Author(s) : Ian Charles Paterson Source : Infect Agent Cancer |
| 18. |
The dynamic roles of TGF-β signalling in EBV-associated cancers.
2018
Source : cancers |
| 19. |
A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.
2018
Author(s) : Ian Charles Paterson Source : Carcinogenesis |
| 20. |
Susceptibility of Human Oral Squamous Cell Carcinoma (OSCC) H103 and H376 cell lines to Retroviral OSKM mediated reprogramming.
2017
Author(s) : Ian Charles Paterson Source : Peer J |
| 21. |
Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis.
2017
Author(s) : Ian Charles Paterson Source : Scientific Reports |
| 22. |
Mechanisms of sphingosine 1-phosphate receptor signalling in cancer.
2017
Author(s) : Ian Charles Paterson Source : Cellular Signalling |
| 23. |
Fibroblast activation and senescence in oral cancer.
2017
Author(s) : Ian Charles Paterson Source : journal of Oral Pathology and Medicine |
| 24. |
Synthesis and biological evaluation of indole core based derivatives with potent antibacterial activity against resistant bacterial pathogens.
2017
Author(s) : Ian Charles Paterson Source : Journal of Antibiotics |
| 25. |
Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3.
2017
Author(s) : Ian Charles Paterson Source : Journal of Pathology |
| 26. |
Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.
2016
Author(s) : Ian Charles Paterson Source : Scientific Reports |
| 27. |
Comparative Genome Analysis of Fusobacterium nucleatum.
2016
Author(s) : Ian Charles Paterson Source : Genome Biology and Evolution |
| 28. |
A new complete mitogenome of the critically endangered Chinese pangolin Manis pentadactyla.
2016
Author(s) : Ian Charles Paterson Source : Conservation Genetics Resources |
| 29. |
Streptobase: An oral streptococcus mitis group genomic resource and analysis platform.
2016
Author(s) : Ian Charles Paterson Source : PLoS One |
| 30. |
A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.
2016
Author(s) : Ian Charles Paterson Source : Aging |
| 31. |
Cell cycle arrest and apoptosis induction via modulation of mitochondrial integrity by Bcl-2 family members and caspase-dependence in Dracaena Cinnabari- treated H400 human oral squamous cell carcinoma.
2016
Author(s) : Ian Charles Paterson Source : Biomed Research International |
| 32. |
Pangolin genomes and the evolution of mammalian scales and immunity.
2016
Source : Genome Research |
| 33. |
PGD: A pangolin genome hub for the research community.
2016
Author(s) : Ian Charles Paterson Source : Database (Oxford) |
| 34. |
HOPX functions as a tumour suppressor in head and neck cancer.
2016
Author(s) : Ian Charles Paterson Source : Scientific Reports |
| 35. |
Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy.
2016
Author(s) : Ian Charles Paterson Source : Scientific Reports |
| 36. |
The opposing roles of NOTCH signalling in head and neck cancer.
2015
Source : Oral Diseases |
| 37. |
The Influence of Glycerol on the Binding of Methotrexate to Mycobacterium tuberculosis Dihydroflolate Reductase: A Molecular Modeling Study.
2015
Author(s) : Ian Charles Paterson |
| 38. |
(6E,10E) Isopolycerasoidol and (6E,10E) Isopolycerasoidol methyl ester, prenylated benzopyran derivatives from Pseuduvaria monticola induce mitochondrial-mediated apoptosis in human breast adenocarcinoma cells.
2015
Author(s) : Ian Charles Paterson Source : PLoS One |
| 39. |
The antineoplastic properties of FTY720: Evidence for the repurposing of fingolimod.
2015
Author(s) : Ian Charles Paterson |
| 40. |
Down-regulation of LPA receptor 5 to aberrant LPA signalling in EBV- associated nasopharyngeal carcinoma.
2015
Author(s) : Ian Charles Paterson Source : Journal of Pathology |
| 41. |
Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas.
2015
Author(s) : Ian Charles Paterson Source : Oral Oncology |
| 42. |
The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling.
2015
Author(s) : Ian Charles Paterson Source : Scientific Reports |
| 43. |
Nickel(II) complex of polyhydroxybenzaldehyde N4- thiosemicarbazone exhibits anti- inflammatory activity by inhibiting NF- B transactivation.
2014
Author(s) : Ian Charles Paterson Source : Plos One |
| 44. |
Identification of the PcrA DNA helicase reaction pathway by applying advanced targeted molecular dynamic simulations
2014
Author(s) : Ian Charles Paterson Source : molecular simulation |
| 45. |
Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling.
2014
Author(s) : Ian Charles Paterson Source : Journal of Molecular Graphics Modelling |
| 46. |
Fusobacterium nucleatum strain W1481, a possible new subspecies isolated from a periodontal pocket.
2014
Author(s) : Ian Charles Paterson Source : Genome Announcements |
| 47. |
Identification of novel small molecule TGF-beta antagonists using structure-based drug design.
2013
Author(s) : Ian Charles Paterson Source : J Comput Aided Mol Des |
| 48. |
The study of interactions between DNA and PcrA DNA helicase by using targeted molecular dynamic simulations.
2013
Author(s) : Ian Charles Paterson |
| 49. |
Genome Sequence of Parvimonas micra Strain A293, Isolated from an Abdominal Abscess from a Patient in the United Kingdom.
2013
Author(s) : Ian Charles Paterson Source : Genome Announcements |
| 50. |
TGF-beta enhances invasion and metastasis in Ras-
transfected human malignant epidermal
keratinocytes
2012
Author(s) : Ian Charles Paterson Source : International Journal of Experimental Pathology |
| 51. |
TGF-beta1 signalling; connecting aberrant inflammation
and colorectal tumorigenesis.
2012
Author(s) : Ian Charles Paterson Source : Current Pharmaceutical Design |
| 52. |
Mitochondrial DNA abnormalities in head and neck
cancer are infrequent and lack prognostic utility.
2011
Author(s) : Ian Charles Paterson |
| 53. |
Lysophosphatidic acid (LPA) and calcitrol drive
human
osteoblastogenesis; requirement of albumin-bound
LPA.
2011
Author(s) : Ian Charles Paterson Source : Prostaglandins & Other Lipid Mediators |
| 54. |
TGF-beta inhibits metastasis in late stage human
squamous
cell carcinoma of the skin by a mechanism that
does
not involve Id1.
2010
Author(s) : Ian Charles Paterson Source : Cancer Letters |
| 55. |
Upregulation of Eps8 in oral squamous cell carcinoma
promotes cell migration and invasion through integrin-
dependent Rac1 activation.
2009
Author(s) : Ian Charles Paterson Source : Oncogene |
| 56. |
Investigating the Conformational Preferences of
Transforming Growth Factor-beta isoforms using
Targeted
Molecular Dynamics Simulations.
2009
Author(s) : Ian Charles Paterson Source : Journal of Chemical Theory and Computation |
| 57. |
Expression of Ki-67 and p53 in cutaneous free flaps
used to reconstruct soft tissue defects following
resection of oral squamous cell carcinoma.
2007
Author(s) : Ian Charles Paterson Source : Oral Oncology |
| 58. |
Spindle assembly checkpoint and centrosome
abnormalities in oral cancer.
2007
Author(s) : Ian Charles Paterson Source : Cancer Letters |
| 59. |
Cell death induced by N-(4-hydroxyphenyl)retinamide in
human epidermal keratinocytes is modulated by TGF-beta
and diminishes during the progression of squamous cell
carcinoma.
2006
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
| 60. |
Dysregulated TGF-beta1-induced Smad signalling
occurs as a result of defects in multiple
components of the TGF-beta signalling pathway in
human head and neck carcinoma cell lines.
2006
Author(s) : Ian Charles Paterson Source : International Journal of Oncology |
| 61. |
Over-expression of TGF-beta1 in Smad4-deficient
human malignant oral carcinoma cells causes
tumour regression in vivo by mechanisms that
sensitize cells to apoptosis.
2005
Author(s) : Ian Charles Paterson Source : Journal of Pathology |
| 62. |
Induction of an epithelial to mesenchymal
transition in human immortal and malignant
keratinocytes by TGF-beta1 involves MAPK, Smad
and AP-1 signalling pathways.
2005
Author(s) : Ian Charles Paterson Source : Journal of Cellular Biochemistry |
| 63. |
TGF-beta signal transduction in oro-facial health
and non-malignant disease (part 1).
2004
Author(s) : Ian Charles Paterson Source : Critical Reviews in Oral Biology |
| 64. |
Metastatic dissemination of human malignant oral
keratinocyte cell lines following orthotopic
transplantation reflects response to TGF-beta1.
2004
Author(s) : Ian Charles Paterson |
| 65. |
DLC1 is unlikely to be a primary target for deletions
on chromosome 8p22 in head and neck squamous cell
carcinoma.
2004
Author(s) : Ian Charles Paterson Source : Genes, chromosomes and cancer |
| 66. |
The role of TGF-beta in epithelial malignancy and
relevance to the pathogenesis of oral cancer
(part 2).
2004
Author(s) : Ian Charles Paterson Source : Critical Reviews in Oral Biology and Medicine |
| 67. |
Attenuated type II TGF-beta receptor signalling
in human malignant oral keratinocytes induces a
less differentiated and more aggressive phenotype
that is
associated with metastatic dissemination.
2004
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
| 68. |
Functional significance of MMP-2 and MMP-9 expression
by human malignant oral keratinocyte cell lines.
2003
Author(s) : Ian Charles Paterson |
| 69. |
The presence of multiple regions of homozygous
deletion at the CSMD1 locus in oral squamous cell
carcinoma question the role of CSMD1 in head and neck
carcinogenesis.
2003
Author(s) : Ian Charles Paterson |
| 70. |
TGF-beta1 acts as a tumor suppressor of human
malignant keratinocytes independently of Smad 4
expression and
ligand-induced G1 arrest.
2002
Author(s) : Ian Charles Paterson Source : Oncogene |
| 71. |
A review of inherited cancer syndromes and their
relevance to oral squamous cell carcinoma.
2001
Author(s) : Ian Charles Paterson Source : Oral Oncology |
| 72. |
Decreased expression of TGF-beta cell surface
receptors during progression of human oral
squamous cell carcinoma.
2001
Author(s) : Ian Charles Paterson |
| 73. |
Expression of a recombinant extracellular domain
of the type-II TGF-beta receptor; utilisation in
a modified ELISA to screen TGF- agonists and
antagonists.
2001
Author(s) : Ian Charles Paterson Source : Analytical Biochemistry |
| 74. |
Overexpression of JunB in undifferentiated malignant
rat oral keratinocytes enhances the malignant
phenotype in vitro without altering cellular
differentiation.
2001
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
| 75. |
Endogenous TGF-beta1 inhibits the growth and
metastatic dissemination of rat oral carcinoma cell
lines but enhances local bone resorption.
2000
Author(s) : Ian Charles Paterson |
| 76. |
DNA studies underestimate the major role of CDKN2A
inactivation in oral and oro-pharyngeal squamous cell
carcinomas.
1999
Author(s) : Ian Charles Paterson |
| 77. |
Loss of differentiation of 4NQO-induced malignant oral
rat keratinocytes correlates with metastatic
dissemination and is associated with a reduced
cellular response to TGF-beta1 and an altered receptor
profile.
1999
Author(s) : Ian Charles Paterson |
| 78. |
FGF receptor expression reflects cellular
differentiation in human oral squamous carcinoma cell
lines.
1998
Author(s) : Ian Charles Paterson Source : Carcinogenesis |
| 79. |
Early genetic and functional events in the
pathogenesis of oral cancer.
1997
Author(s) : Ian Charles Paterson Source : Radiation Oncology Investigations |
| 80. |
of autocrine TGF-beta1 suppresses the growth of
spindle epithelial cells in vitro and in vivo in the
rat 4NQO model of oral carcinogenesis.
1997
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
| 81. |
p53 expression in odontogenic keratocyst epithelium.
1996
Author(s) : Ian Charles Paterson |
| 82. |
Dysregulation of autocrine TGF-beta isoform production
and ligand responses in human tumour-derived and Ha-
ras-transfected keratinocytes and fibroblasts.
1996
Author(s) : Ian Charles Paterson |
| 83. |
Molecular changes in oral cancer may reflect ethnic
origin and aetiology.
1996
Author(s) : Ian Charles Paterson Source : Oral Oncology |
| 84. |
TGF-beta isoforms fail to modulate inositol phosphates
and cAMP in normal and tumour-derived human oral
keratinocytes.
1996
Author(s) : Ian Charles Paterson Source : Biochimica et Biophysica Acta |
| 85. |
Cloning and sequence-analysis of an intron-containing
domain from a peptide synthetase encoding of the
entomopathogenic fungus Metarhizium anisopliae.
1996
Author(s) : Ian Charles Paterson Source : Gene |
| 86. |
Effects of transforming growth factor beta-1 on growth
regulatory genes in tumour-derived human oral
keratinocytes.
1995
Author(s) : Ian Charles Paterson Source : Brisitsh Journal of Cancer |
| 87. |
Presence of human papillomavirus sequences in tumour-
derived human oral keratinocytes which express mutant
p53.
1995
Author(s) : Ian Charles Paterson Source : Oral Oncology |
| 88. |
Cuticle degrading proteases from insect moulting fluid
and culture filtrates of entomopathogenic fungi.
1995
Author(s) : Ian Charles Paterson Source : Comparative Biochemistry and Physiology |
| 89. |
Cloning and characterisation of a gene encoding a
cuticle-degrading protease from the insect pathogenic
fungus Metarhizium anisopliae.
1995
Author(s) : Ian Charles Paterson Source : Gene |
| 90. |
Specific induction of a cuticle-degrading protease of
the insect pathogenic fungus Metarhizium anisopliae.
1994
Author(s) : Ian Charles Paterson Source : Microbiology |
| 91. |
Paterson IC, Charnley AK, Cooper RM, Clarkson JM.
Partial characterisation of specific inducers of a
cuticle-degrading protease from the entomopathogenic
fungus Metarhizium anisopliae.
1994
Author(s) : Ian Charles Paterson Source : Microbiology |
| 92. |
TGF-beta receptor regulation mediates the response to
exogenous ligand but is independent of the degree of
cellular differentiation in human oral keratinocytes.
1994
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
| 93. |
Molecular events including p53 and k-ras alterations
in the in vitro progression of a human colorectal
adenoma cell line to an adenocarcinoma.
1993
Author(s) : Ian Charles Paterson Source : Oncogene |
| 94. |
The regulation of production of a fungal trypsin by
Metarhizium anisopliae.
1993
Author(s) : Ian Charles Paterson Source : FEMS Microbiol Lett |
PROCEEDING
| NO | DETAILS OF PROCEEDING |
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LETTER
| NO | DETAILS OF LETTER |
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MASS MEDIA(NEWSPAPER,RADIO,TV,POPULAR MAGAZINE)
| NO | DETAILS OF MASS MEDIA(NEWSPAPER,RADIO,TV,POPULAR MAGAZINE) |
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RESEARCH PROJECT
| GRANT | PROGRESS | STATUS |
|---|---|---|
|
Senescence and Autophagy in Cancer-associated Fibroblasts (CAFs) of Oral Squamous Cell Carcinoma (OSCC)
Researcher(s) : -
(Postgraduate Research Grant (PPP) - Research) |
|
end |
|
Targeting Sphingosine Kinases: A Novel Therapy For Oral Cancer
Researcher(s) : Associate Prof. Dr. Yap Lee Fah
(Bantuan Khas Penyelidikan (BKP Special)) |
|
end |
|
Stromal Fibroblasts As Mediators Of Chemoresistance In Oral Carcinoma Cells
Researcher(s) : Prof. Dr. Ivy Chung,Associate Prof. Dr. Yap Lee Fah
(Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness)) |
|
end |
RESEARCH COLLABORATOR
| GRANT | PROGRESS | STATUS |
|---|---|---|
|
Top-down: Characterisation Of Tumours From Chineseand Sarawak Native Patients With Nasopharyngeal Carcinoma
Researcher(s) : Prof. Dr. Ian Charles Paterson,Associate Prof. Dr. Zuraiza Binti Mohamad Zaini,Paul Gerard Murray,Joe Yeong Poh Sheng
(Others MOHE - Top 100 (IIRG)-FNW) |
|
on going |
|
Investigating The Role Of Ykl-40 As A Positive Regulator Of Angiogenesis During Malignant Transformation
(Fundamental Research Grant Scheme (FRGS)) |
|
on going |
|
Elucidating The Functional Significance Of Epstein-barr Virus Lytic Genes In Nasopharyngeal Carcinoma
Researcher(s) : Prof. Dr. Ian Charles Paterson,Associate Prof. Dr. Ng Ching Ching,Maizaton Atmadini Abdullah,Paul Gerard Murray,Lo Kwok-wai
(Fundamental Research Grant Scheme (FRGS)) |
|
end |
|
Investigating Anti-tumor T Cell Responses In Nasopharyngeal Carcinoma To Refine Vaccine-based
Researcher(s) : Prof. Dr. Ian Charles Paterson
(International Funding) |
|
end |
|
MicroRNA Regulation in Cancer Associated Fibroblasts (CAFs) phenotype
Researcher(s) : Prof. Dr. Ian Charles Paterson
(Bantuan Kecil Penyelidikan (BKP)) |
|
end |
|
Contribution Of Epstein-barr Virus (ebv) To The Gene Expression Programme Of Nasopharyngeal Carcinoma
Researcher(s) : Prof. Dr. Ian Charles Paterson,Prof. Dr. Saiful Anuar Bin Karsani
(Fundamental Research Grant Scheme (FRGS)) |
|
end |
|
Establishment Of Malaysian Oral Cancer Cell Lines And Apoptosis Induction Of Oral Cancer Cells Response To Damnacanthal And Nordamnacanthal Extract
Researcher(s) : Dr. Choon Yee Fan,Dato' Prof. Dr. Zainal Ariff Bin Abdul Rahman,Prof. Dr. Noor Hayaty Binti Abu Kasim,Prof. Dr. Ian Charles Paterson,Associate Prof. Dr. Thomas George Kallarakkal
(Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness)) |
|
end |
|
Cell Signaling Molecules As Potential Biomakers And Therapeutic Targets For Oscc
Researcher(s) : Prof. Dr. Ian Charles Paterson,Dr. Choon Yee Fan,Dr. Karen Ng Lee Peng,Prof. Dr. Rosnah Binti Mohd Zain
(Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness)) |
|
end |
|
The Notch Signalling Pathway And Treatment Resistance In Head And Neck Cancer
Researcher(s) : Prof. Dr. Ian Charles Paterson,Prof. Dr. Rosnah Binti Mohd Zain,Christopher Dawson
(Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness)) |
|
end |
|
Antitumor Effect And Apoptosis Induction Of Phyllanthus Amarus And Dracaena Cinnabari On Oral Cancer Cell Lines In Vitro And In Vivo
Researcher(s) : Prof. Dr. Rosnah Binti Mohd Zain,Prof. Dr. Noor Hayaty Binti Abu Kasim,Prof. Dr. Ian Charles Paterson
(Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness)) |
|
end |