ARTICLE IN ACADEMIC JOURNALS
NO | DETAILS OF ARTICLE IN ACADEMIC JOURNALS |
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1. |
Autophagy is deregulated in cancer-associated fibroblasts from oral cancer and is stimulated during the induction of fibroblast senescence by TGF- 1.
2021
Author(s) : Ian Charles Paterson Source : Scientific Reports |
2. |
Myofibroblast transdifferentiation is associated with changes in cellular and extracellular ves.icle miRNA abundance
2021
Source : PLOS ONE |
3. |
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF- B activation and immune escape.
2021
Author(s) : Ian Charles Paterson,Yap Lee Fah Source : Nature Communications |
4. |
3D Clumps/Extracellular Matrix Complexes of Periodontal Ligament Stem Cells Ameliorate the Attenuating Effects of LPS on Proliferation and Osteogenic Potential.
2021
Source : JOURNAL OF PERSONALIZED MEDICINE |
5. |
P2Y purinergic receptor signaling in oral squamous cell carcinoma cell lines and its role in proliferation and cisplatin-mediated apoptosis.
2021
Author(s) : Ian Charles Paterson Source : Sains Malaysiana |
6. |
Establishing a technique for isolation and characterization of human periodontal ligament derived mesenchymal stem cells.
2021
Author(s) : Ian Charles Paterson Source : SAUDI DENTAL JOURNAL |
7. |
The development of a novel transforming growth factor- (TGF- ) inhibitor that disrupts ligand-receptor interactions.
2020
Author(s) : Ian Charles Paterson Source : Eur J Med Chem |
8. |
Development of small molecule inhibitors targeting TGF-β ligand and receptor: Structures, mechanism, preclinical studies and clinical usage.
2020
Author(s) : Ian Charles Paterson Source : European Journal of Medicinal Chemistry |
9. |
Deregulation of lysophosphatidic acid metabolism in oral cancer promotes cell migration via the up-regulation of COX-2.
2020
Author(s) : Chai Wen Lin,Ian Charles Paterson Source : Peer J DOI : 10.7717/peerj.10328 |
10. |
Profiling lysophosphatidic acid levels in plasma from head and neck cancer patients.
2020
Source : Peer J DOI : 10.7717/peerj.9304 |
11. |
Monoamine oxidase A is downregulated in EBV-associated nasopharyngeal carcinoma.
2020
Author(s) : Ian Charles Paterson Source : Scientific Reports |
12. |
Collagen induces a more proliferative, migratory and chemoresistant phenotype in head and neck cancer via DDR1.
2019
Author(s) : Ian Charles Paterson,Anand Ramanathan Source : Cancers |
13. |
Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks.
2019
Source : BMC GENOMICS |
14. |
Cisplatin-Resistance in Oral Squamous Cell Carcinoma: Regulation by Tumor Cell-Derived Extracellular Vesicles.
2019
Author(s) : Ian Charles Paterson Source : Cancers |
15. |
In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5-HT2 and 1 receptors.
2019
Author(s) : Ian Charles Paterson Source : chemical biology and drug design |
16. |
Synthesis and evaluation of nuciferine and roemerine enantiomers as 5-HT2 and 1 receptor antagonists.
2018
Author(s) : Ian Charles Paterson Source : MedChemComm |
17. |
Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection.
2018
Author(s) : Ian Charles Paterson Source : Infect Agent Cancer |
18. |
The dynamic roles of TGF-β signalling in EBV-associated cancers.
2018
Source : cancers |
19. |
A miRNA-145/TGF-β1 negative feedback loop regulates the cancer-associated fibroblast phenotype.
2018
Author(s) : Ian Charles Paterson Source : Carcinogenesis |
20. |
Susceptibility of Human Oral Squamous Cell Carcinoma (OSCC) H103 and H376 cell lines to Retroviral OSKM mediated reprogramming.
2017
Author(s) : Ian Charles Paterson Source : Peer J |
21. |
Distinct Biological Potential of Streptococcus gordonii and Streptococcus sanguinis Revealed by Comparative Genome Analysis.
2017
Author(s) : Ian Charles Paterson Source : Scientific Reports |
22. |
Mechanisms of sphingosine 1-phosphate receptor signalling in cancer.
2017
Author(s) : Ian Charles Paterson Source : Cellular Signalling |
23. |
Fibroblast activation and senescence in oral cancer.
2017
Author(s) : Ian Charles Paterson Source : journal of Oral Pathology and Medicine |
24. |
Synthesis and biological evaluation of indole core based derivatives with potent antibacterial activity against resistant bacterial pathogens.
2017
Author(s) : Ian Charles Paterson Source : Journal of Antibiotics |
25. |
Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3.
2017
Author(s) : Ian Charles Paterson Source : Journal of Pathology |
26. |
Aberrant expression of the S1P regulating enzymes, SPHK1 and SGPL1, contributes to a migratory phenotype in OSCC mediated through S1PR2.
2016
Author(s) : Ian Charles Paterson Source : Scientific Reports |
27. |
Comparative Genome Analysis of Fusobacterium nucleatum.
2016
Author(s) : Ian Charles Paterson Source : Genome Biology and Evolution |
28. |
A new complete mitogenome of the critically endangered Chinese pangolin Manis pentadactyla.
2016
Author(s) : Ian Charles Paterson Source : Conservation Genetics Resources |
29. |
Streptobase: An oral streptococcus mitis group genomic resource and analysis platform.
2016
Author(s) : Ian Charles Paterson Source : PLoS One |
30. |
A miR-335/COX-2/PTEN axis regulates the secretory phenotype of senescent cancer-associated fibroblasts.
2016
Author(s) : Ian Charles Paterson Source : Aging |
31. |
Cell cycle arrest and apoptosis induction via modulation of mitochondrial integrity by Bcl-2 family members and caspase-dependence in Dracaena Cinnabari- treated H400 human oral squamous cell carcinoma.
2016
Author(s) : Ian Charles Paterson Source : Biomed Research International |
32. |
Pangolin genomes and the evolution of mammalian scales and immunity.
2016
Source : Genome Research |
33. |
PGD: A pangolin genome hub for the research community.
2016
Author(s) : Ian Charles Paterson Source : Database (Oxford) |
34. |
HOPX functions as a tumour suppressor in head and neck cancer.
2016
Author(s) : Ian Charles Paterson Source : Scientific Reports |
35. |
Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy.
2016
Author(s) : Ian Charles Paterson Source : Scientific Reports |
36. |
The opposing roles of NOTCH signalling in head and neck cancer.
2015
Source : Oral Diseases |
37. |
The Influence of Glycerol on the Binding of Methotrexate to Mycobacterium tuberculosis Dihydroflolate Reductase: A Molecular Modeling Study.
2015
Author(s) : Ian Charles Paterson |
38. |
(6E,10E) Isopolycerasoidol and (6E,10E) Isopolycerasoidol methyl ester, prenylated benzopyran derivatives from Pseuduvaria monticola induce mitochondrial-mediated apoptosis in human breast adenocarcinoma cells.
2015
Author(s) : Ian Charles Paterson Source : PLoS One |
39. |
The antineoplastic properties of FTY720: Evidence for the repurposing of fingolimod.
2015
Author(s) : Ian Charles Paterson |
40. |
Down-regulation of LPA receptor 5 to aberrant LPA signalling in EBV- associated nasopharyngeal carcinoma.
2015
Author(s) : Ian Charles Paterson Source : Journal of Pathology |
41. |
Gene expression profiling reveals biological pathways responsible for phenotypic heterogeneity between UK and Sri Lankan oral squamous cell carcinomas.
2015
Author(s) : Ian Charles Paterson Source : Oral Oncology |
42. |
The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling.
2015
Author(s) : Ian Charles Paterson Source : Scientific Reports |
43. |
Nickel(II) complex of polyhydroxybenzaldehyde N4- thiosemicarbazone exhibits anti- inflammatory activity by inhibiting NF- B transactivation.
2014
Author(s) : Ian Charles Paterson Source : Plos One |
44. |
Identification of the PcrA DNA helicase reaction pathway by applying advanced targeted molecular dynamic simulations
2014
Author(s) : Ian Charles Paterson Source : molecular simulation |
45. |
Investigating the binding preferences of small molecule inhibitors of human protein arginine methyltransferase 1 using molecular modelling.
2014
Author(s) : Ian Charles Paterson Source : Journal of Molecular Graphics Modelling |
46. |
Fusobacterium nucleatum strain W1481, a possible new subspecies isolated from a periodontal pocket.
2014
Author(s) : Ian Charles Paterson Source : Genome Announcements |
47. |
Identification of novel small molecule TGF-beta antagonists using structure-based drug design.
2013
Author(s) : Ian Charles Paterson Source : J Comput Aided Mol Des |
48. |
The study of interactions between DNA and PcrA DNA helicase by using targeted molecular dynamic simulations.
2013
Author(s) : Ian Charles Paterson |
49. |
Genome Sequence of Parvimonas micra Strain A293, Isolated from an Abdominal Abscess from a Patient in the United Kingdom.
2013
Author(s) : Ian Charles Paterson Source : Genome Announcements |
50. |
TGF-beta enhances invasion and metastasis in Ras-
transfected human malignant epidermal
keratinocytes
2012
Author(s) : Ian Charles Paterson Source : International Journal of Experimental Pathology |
51. |
TGF-beta1 signalling; connecting aberrant inflammation
and colorectal tumorigenesis.
2012
Author(s) : Ian Charles Paterson Source : Current Pharmaceutical Design |
52. |
Mitochondrial DNA abnormalities in head and neck
cancer are infrequent and lack prognostic utility.
2011
Author(s) : Ian Charles Paterson |
53. |
Lysophosphatidic acid (LPA) and calcitrol drive
human
osteoblastogenesis; requirement of albumin-bound
LPA.
2011
Author(s) : Ian Charles Paterson Source : Prostaglandins & Other Lipid Mediators |
54. |
TGF-beta inhibits metastasis in late stage human
squamous
cell carcinoma of the skin by a mechanism that
does
not involve Id1.
2010
Author(s) : Ian Charles Paterson Source : Cancer Letters |
55. |
Upregulation of Eps8 in oral squamous cell carcinoma
promotes cell migration and invasion through integrin-
dependent Rac1 activation.
2009
Author(s) : Ian Charles Paterson Source : Oncogene |
56. |
Investigating the Conformational Preferences of
Transforming Growth Factor-beta isoforms using
Targeted
Molecular Dynamics Simulations.
2009
Author(s) : Ian Charles Paterson Source : Journal of Chemical Theory and Computation |
57. |
Expression of Ki-67 and p53 in cutaneous free flaps
used to reconstruct soft tissue defects following
resection of oral squamous cell carcinoma.
2007
Author(s) : Ian Charles Paterson Source : Oral Oncology |
58. |
Spindle assembly checkpoint and centrosome
abnormalities in oral cancer.
2007
Author(s) : Ian Charles Paterson Source : Cancer Letters |
59. |
Cell death induced by N-(4-hydroxyphenyl)retinamide in
human epidermal keratinocytes is modulated by TGF-beta
and diminishes during the progression of squamous cell
carcinoma.
2006
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
60. |
Dysregulated TGF-beta1-induced Smad signalling
occurs as a result of defects in multiple
components of the TGF-beta signalling pathway in
human head and neck carcinoma cell lines.
2006
Author(s) : Ian Charles Paterson Source : International Journal of Oncology |
61. |
Over-expression of TGF-beta1 in Smad4-deficient
human malignant oral carcinoma cells causes
tumour regression in vivo by mechanisms that
sensitize cells to apoptosis.
2005
Author(s) : Ian Charles Paterson Source : Journal of Pathology |
62. |
Induction of an epithelial to mesenchymal
transition in human immortal and malignant
keratinocytes by TGF-beta1 involves MAPK, Smad
and AP-1 signalling pathways.
2005
Author(s) : Ian Charles Paterson Source : Journal of Cellular Biochemistry |
63. |
TGF-beta signal transduction in oro-facial health
and non-malignant disease (part 1).
2004
Author(s) : Ian Charles Paterson Source : Critical Reviews in Oral Biology |
64. |
Metastatic dissemination of human malignant oral
keratinocyte cell lines following orthotopic
transplantation reflects response to TGF-beta1.
2004
Author(s) : Ian Charles Paterson |
65. |
DLC1 is unlikely to be a primary target for deletions
on chromosome 8p22 in head and neck squamous cell
carcinoma.
2004
Author(s) : Ian Charles Paterson Source : Genes, chromosomes and cancer |
66. |
The role of TGF-beta in epithelial malignancy and
relevance to the pathogenesis of oral cancer
(part 2).
2004
Author(s) : Ian Charles Paterson Source : Critical Reviews in Oral Biology and Medicine |
67. |
Attenuated type II TGF-beta receptor signalling
in human malignant oral keratinocytes induces a
less differentiated and more aggressive phenotype
that is
associated with metastatic dissemination.
2004
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
68. |
Functional significance of MMP-2 and MMP-9 expression
by human malignant oral keratinocyte cell lines.
2003
Author(s) : Ian Charles Paterson |
69. |
The presence of multiple regions of homozygous
deletion at the CSMD1 locus in oral squamous cell
carcinoma question the role of CSMD1 in head and neck
carcinogenesis.
2003
Author(s) : Ian Charles Paterson |
70. |
TGF-beta1 acts as a tumor suppressor of human
malignant keratinocytes independently of Smad 4
expression and
ligand-induced G1 arrest.
2002
Author(s) : Ian Charles Paterson Source : Oncogene |
71. |
A review of inherited cancer syndromes and their
relevance to oral squamous cell carcinoma.
2001
Author(s) : Ian Charles Paterson Source : Oral Oncology |
72. |
Decreased expression of TGF-beta cell surface
receptors during progression of human oral
squamous cell carcinoma.
2001
Author(s) : Ian Charles Paterson |
73. |
Expression of a recombinant extracellular domain
of the type-II TGF-beta receptor; utilisation in
a modified ELISA to screen TGF- agonists and
antagonists.
2001
Author(s) : Ian Charles Paterson Source : Analytical Biochemistry |
74. |
Overexpression of JunB in undifferentiated malignant
rat oral keratinocytes enhances the malignant
phenotype in vitro without altering cellular
differentiation.
2001
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
75. |
Endogenous TGF-beta1 inhibits the growth and
metastatic dissemination of rat oral carcinoma cell
lines but enhances local bone resorption.
2000
Author(s) : Ian Charles Paterson |
76. |
DNA studies underestimate the major role of CDKN2A
inactivation in oral and oro-pharyngeal squamous cell
carcinomas.
1999
Author(s) : Ian Charles Paterson |
77. |
Loss of differentiation of 4NQO-induced malignant oral
rat keratinocytes correlates with metastatic
dissemination and is associated with a reduced
cellular response to TGF-beta1 and an altered receptor
profile.
1999
Author(s) : Ian Charles Paterson |
78. |
FGF receptor expression reflects cellular
differentiation in human oral squamous carcinoma cell
lines.
1998
Author(s) : Ian Charles Paterson Source : Carcinogenesis |
79. |
Early genetic and functional events in the
pathogenesis of oral cancer.
1997
Author(s) : Ian Charles Paterson Source : Radiation Oncology Investigations |
80. |
of autocrine TGF-beta1 suppresses the growth of
spindle epithelial cells in vitro and in vivo in the
rat 4NQO model of oral carcinogenesis.
1997
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
81. |
p53 expression in odontogenic keratocyst epithelium.
1996
Author(s) : Ian Charles Paterson |
82. |
Dysregulation of autocrine TGF-beta isoform production
and ligand responses in human tumour-derived and Ha-
ras-transfected keratinocytes and fibroblasts.
1996
Author(s) : Ian Charles Paterson |
83. |
Molecular changes in oral cancer may reflect ethnic
origin and aetiology.
1996
Author(s) : Ian Charles Paterson Source : Oral Oncology |
84. |
TGF-beta isoforms fail to modulate inositol phosphates
and cAMP in normal and tumour-derived human oral
keratinocytes.
1996
Author(s) : Ian Charles Paterson Source : Biochimica et Biophysica Acta |
85. |
Cloning and sequence-analysis of an intron-containing
domain from a peptide synthetase encoding of the
entomopathogenic fungus Metarhizium anisopliae.
1996
Author(s) : Ian Charles Paterson Source : Gene |
86. |
Effects of transforming growth factor beta-1 on growth
regulatory genes in tumour-derived human oral
keratinocytes.
1995
Author(s) : Ian Charles Paterson Source : Brisitsh Journal of Cancer |
87. |
Presence of human papillomavirus sequences in tumour-
derived human oral keratinocytes which express mutant
p53.
1995
Author(s) : Ian Charles Paterson Source : Oral Oncology |
88. |
Cuticle degrading proteases from insect moulting fluid
and culture filtrates of entomopathogenic fungi.
1995
Author(s) : Ian Charles Paterson Source : Comparative Biochemistry and Physiology |
89. |
Cloning and characterisation of a gene encoding a
cuticle-degrading protease from the insect pathogenic
fungus Metarhizium anisopliae.
1995
Author(s) : Ian Charles Paterson Source : Gene |
90. |
Specific induction of a cuticle-degrading protease of
the insect pathogenic fungus Metarhizium anisopliae.
1994
Author(s) : Ian Charles Paterson Source : Microbiology |
91. |
Paterson IC, Charnley AK, Cooper RM, Clarkson JM.
Partial characterisation of specific inducers of a
cuticle-degrading protease from the entomopathogenic
fungus Metarhizium anisopliae.
1994
Author(s) : Ian Charles Paterson Source : Microbiology |
92. |
TGF-beta receptor regulation mediates the response to
exogenous ligand but is independent of the degree of
cellular differentiation in human oral keratinocytes.
1994
Author(s) : Ian Charles Paterson Source : INTERNATIONAL JOURNAL OF CANCER |
93. |
Molecular events including p53 and k-ras alterations
in the in vitro progression of a human colorectal
adenoma cell line to an adenocarcinoma.
1993
Author(s) : Ian Charles Paterson Source : Oncogene |
94. |
The regulation of production of a fungal trypsin by
Metarhizium anisopliae.
1993
Author(s) : Ian Charles Paterson Source : FEMS Microbiol Lett |
PROCEEDING
NO | DETAILS OF PROCEEDING |
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RESEARCH PROJECT
GRANT | PROGRESS | STATUS |
---|---|---|
Senescence and Autophagy in Cancer-associated Fibroblasts (CAFs) of Oral Squamous Cell Carcinoma (OSCC)
Researcher(s) : -
(Postgraduate Research Grant (PPP) - Research) |
|
end |
Targeting Sphingosine Kinases: A Novel Therapy For Oral Cancer
Researcher(s) : Associate Prof. Dr. Yap Lee Fah
(Bantuan Khas Penyelidikan (BKP Special)) |
|
end |
Programme Title: Oncogenesis Of Head And Neck Cancer: Initiation, Progression And Heterogeneity.Project Title: Mechanisms Of Oral Carcinogenesis: From Homeostasis To Drug Discovery.
(High Impact Research - Ministry of Education (HIR-MOE) Cycle 2) |
|
end |
Stromal Fibroblasts As Mediators Of Chemoresistance In Oral Carcinoma Cells
Researcher(s) : Prof. Dr. Ivy Chung,Associate Prof. Dr. Yap Lee Fah
(Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness)) |
|
end |
RESEARCH COLLABORATOR
GRANT | PROGRESS | STATUS |
---|---|---|
Investigating Anti-tumor T Cell Responses In Nasopharyngeal Carcinoma To Refine Vaccine-based
Researcher(s) : Prof. Dr. Ian Charles Paterson
(International Funding) |
|
end |
Anti-proliferative Activity And Mechanism Of Apoptosis Induction Of Ficus Deltoidea On Oral Cancer Cells In Vitro And In Vivo
Researcher(s) : Prof. Dr. Ian Charles Paterson,Aied Mohammed Hamood Saeed
(Fundamental Research Grant Scheme (FRGS)) |
|
end |
Contribution Of Epstein-barr Virus (ebv) To The Gene Expression Programme Of Nasopharyngeal Carcinoma
Researcher(s) : Prof. Dr. Ian Charles Paterson,Prof. Dr. Saiful Anuar Bin Karsani
(Fundamental Research Grant Scheme (FRGS)) |
|
end |
Establishment Of Malaysian Oral Cancer Cell Lines And Apoptosis Induction Of Oral Cancer Cells Response To Damnacanthal And Nordamnacanthal Extract
Researcher(s) : Dr. Choon Yee Fan,Dato' Prof. Dr. Zainal Ariff Bin Abdul Rahman,Prof. Dr. Noor Hayaty Binti Abu Kasim,Prof. Dr. Ian Charles Paterson,Prof. Dr. Thomas George Kallarakkal
(Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness)) |
|
end |
Comparative Analysis Of Oral Pathogens: Streptococcus Gordonii And Streptococcus Sanguinis
Researcher(s) : Prof. Dr. Ian Charles Paterson,Prof. Dr. Fathilah Binti Abdul Razak,Associate Prof. Dr. Marina Binti Mohd Bakri,Dr. Nicholas Jakubovics
(Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness)) |
|
end |
Cell Signaling Molecules As Potential Biomakers And Therapeutic Targets For Oscc
Researcher(s) : Prof. Dr. Ian Charles Paterson,Dr. Choon Yee Fan,Dr. Karen Ng Lee Peng,Prof. Dr. Rosnah Binti Mohd Zain
(Geran Penyelidikan Universiti Malaya (UMRG Programme) - HTM (Wellness)) |
|
end |
The Notch Signalling Pathway And Treatment Resistance In Head And Neck Cancer
Researcher(s) : Prof. Dr. Ian Charles Paterson,Prof. Dr. Rosnah Binti Mohd Zain,Christopher Dawson
(Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness)) |
|
end |
Antitumor Effect And Apoptosis Induction Of Phyllanthus Amarus And Dracaena Cinnabari On Oral Cancer Cell Lines In Vitro And In Vivo
Researcher(s) : Prof. Dr. Rosnah Binti Mohd Zain,Prof. Dr. Noor Hayaty Binti Abu Kasim,Prof. Dr. Ian Charles Paterson
(Geran Penyelidikan Universiti Malaya (UMRG) - HTM (Wellness)) |
|
end |