Curriculum Vitae

DR. NG CHEAN HUI

Senior Lecturer
  • Department of Pharmaceutical Chemistry
    Faculty of Pharmacy
  • chng
  • 0379677022

AREAS OF EXPERTISE

  • MEDICINAL CHEMISTRY
    Drug Synthesis & Modifications (based on natural lead compound); Computer-Aided Drug Design (Docking, Molecular Dynamic Simulation & QSAR)
  • DRUG DISCOVERY
    Natural Product Chemistry

ACADEMIC QUALIFICATION

  • PhD (Medicinal Chemistry), (Medicinal Chemistry)
    Universiti Putra Malaysia (UPM)
  • B.Sc (INDUSTRIAL CHEMISTRY), (Industrial Chemistry)
    Universiti Malaysia Sabah (Ums)

ADMINISTRATIVE DUTIES

  • Assistant Quality Manager - PT06 (Value Creation & Enterprise)
    01 Sep 2024 - 31 Dec 2026 (Faculty)
  • Internal Auditor (Research Grants under the Ministry of Higher Education Malaysia)
    27 Aug 2024 - 29 Aug 2024 (National)
  • Program Manager of Master of Pharmacy (Research) (MSU)
    01 Sep 2021 - 12 Jul 2024 (National)
  • Head of Pharmaceutical Chemistry Unit, School of Pharmacy (MSU)
    01 Aug 2022 - 31 Jan 2024 (National)

MEMBERSHIPS

  • MALAYSIAN INSTITUTE OF CHEMISTRY, MEMBER
    Since 2019 (National)
  • INTERNATIONAL NATURAL PRODUCT SCIENCES TASKFORCE, MEMBER
    Since 2018 (International)
  • MALAYSIAN NATURAL PRODUCTS SOCIETY (MNPS), MEMBER
    Since 2018 (National)
  • EDITORIAL BOARD FOR AUSTRALIAN JOURNAL OF SCIENCE AND TECHNOLOGY, EDITORIAL BOARD
    Since 2018 (International)

AWARD AND STEWARDSHIP

  • MTE 2023: International Innovation Bronze Award
    Malaysia Technology Expo, 2023 (National)
  • ITEX 2023 Gold Medal
    34th International Invention, Innovation, Technology Competition & Exhibition, Malaysia, 2023 (International)
  • MTE AHLS 2023: Innovative Collaboration Bronze Award
    Malaysian Technology Expo: Advanced Healthcare and Life Sciences (MTE-AHLS), 2023 (National)
  • Best Industry Collaboration in Research
    Management and Science University, 2023 (University)
  • Best Teaching and Learning
    Management and Science University, 2019 (University)

PUBLICATIONS

Article in Journal
  1. Segaran, R. T., Ng, C. H., Aluwi, M. F. F. M., Lam, K. W., Shaari, K., & Pisar, M. M. (2024). An eco-friendly and new facile method for synthesis of prenylated or geranylated acylphloroglucinol-based xanthenones. Results in Chemistry, 9, 101627.
  2. Arumainathan, K., Kiew, S. F., Ng, C. H., Panau, F., Anasamy, T., & Kue, C. S. (2023). Hydroalcoholic Moringa oleifera L. Leaf Extracts Ameliorate Alcohol-induced Steatohepatitis in Zebrafish Larvae. Malaysian Journal of Medicine & Health Sciences, 19.
  3. Xin, Y. K., Navaneetharajah, D., Amat, N., Zulkifli, N., Hui, N. C., Said, S. M., & Tang, S. G. H. (2023). PHYSICAL CHARACTERIZATION OF GREEN SYNTHESIZED SILVER NANOPARTICLES USING BROWN SEAWEED SARGASSUM BINDERI. Malaysian Journal of Microscopy, 19(1), 259-270.
  4. Sazali, N. S., Pauzi, F. N. M., Al-Dhalli, S., & Ng, C. H. (2022). Photoprotective and antioxidant effects of Citrus limon and Citrus sinensis Peels: Comparative investigation of the efficiency of five extraction solvents. Medicinal Plants-International Journal of Phytomedicines and Related Industries, 14(2), 284-292.
  5. CHIONG, S. W., NG, C. H., & SHAARI, K. (2021). IN SILICO STUDIES ON DIACYL DERIVATIVES OF PHLOROGLUCINOL TO ENHANCE PHARMACODYNAMIC AND PHARMACOKINETIC PROFILES OF 2, 4, 6-TRIHYDROXY-3-GERANYL-ACETOPHENONE. Int J App Pharm, 13(2), 173-179.
  6. Chuah, P. N., Nyanasegaram, D., Yu, K. X., Mohamed Razik, R., Al-Dhalli, S., Kue, C. S., ... & Ng, C. H. (2020). Comparative conventional extraction methods of ethanolic extracts of Clinacanthus nutans leaves on antioxidant activity and toxicity. British Food Journal, 122(10), 3139-3149.
  7. Khan, J., Kusmahani, S. H., Ruhi, S., Al-Dhalli, S., Kaleemullah, M., Saad, R., ... & Yusuf, E. (2020). Design and evaluation of sustained release matrix tablet of flurbiprofen by using hydrophilic polymer and natural gum. International Journal of Medical Toxicology & Legal Medicine, 23(1and2), 149-159.
  8. Khan, J., Leenoos, L. M., Ruhi, S., Al-Dhalli, S., Kaleemullah, M., Saad, R., ... & Yusuf, E. (2020). Development and evaluation of polyherbal halal ointment using honey and Papaya. International Journal of Medical Toxicology & Legal Medicine, 23(1and2), 232-238.
  9. Khan, J., Norfarhani, S., Sahu, R. K., Ruhi, S., Kaleemullah, M., Al-Dhalli, S., ... & Yusuf, E. (2020). Development and Evaluation of topical Emulgel of Aspirin using different Polymeric Bases. Research journal of pharmacy and technology, 13(12), 6300-6304.
  10. Mohamad Shariff, N. F. S., Singgampalam, T., Ng, C. H., & Kue, C. S. (2020). Antioxidant activity and zebrafish teratogenicity of hydroalcoholic Moringa oleifera L. leaf extracts. British Food Journal, 122(10), 3129-3137.
  11. Segaran, R. A., Ng, C. H., & Al-Dhalli, S. (2020). Antifungal activity of successive extracts of Citrus limon peel for an antidandruff shampoo formulation. International Journal of Medical Toxicology & Legal Medicine, 23(1and2), 59-68.
  12. Shukri, N. S. B., Kaleemullah, M., Khan, J., Al-Dhalli, S., Ruhi, S., Rasny, M., ... & Abdullah, I. (2020). Development and evaluation of halal herbal capsule containing Momordica charantia extract. International Journal of Medical Toxicology & Legal Medicine, 23(3and4), 29-34.
  13. Selvam, D. A., Ng, C. H., Razik, R. M., Al-Dhalli, S., & Shaari, K. (2019). Effects of extraction methods on antibacterial activity of Centella asiatica leaves against pathogenic Staphylococcus aureus and Escherichia coli. International Journal of Medical Toxicology & Legal Medicine, 22(1and2), 172-178.
  14. Yu, K. X., Norhisham, S. N., & Ch, N. G. (2019). Antimicrobial potential of Padina australis and Sargassum polycystum against respiratory infections causing bacteria. International Journal of Medical Toxicology & Legal Medicine, 22(1and2), 138-141.
  15. Ng, C. H., Rullah, K., Abas, F., Lam, K. W., Ismail, I. S., Jamaludin, F., & Shaari, K. (2018). Hits-to-lead optimization of the natural compound 2, 4, 6-trihydroxy-3-geranyl-acetophenone (tHGA) as a potent LOX inhibitor: Synthesis, structure-activity relationship (SAR) study, and computational assignment. Molecules, 23(10), 2509.
  16. Tan, J. W., Israf, D. A., Harith, H. H., Hashim, N. F. M., Ng, C. H., Shaari, K., & Tham, C. L. (2017). Anti-allergic activity of 2, 4, 6-trihydroxy-3-geranylacetophenone (tHGA) via attenuation of IgE-mediated mast cell activation and inhibition of passive systemic anaphylaxis. Toxicology and Applied Pharmacology, 319, 47-58.
  17. Chong, Y. J., Musa, N. F., Ng, C. H., Shaari, K., Israf, D. A., & Tham, C. L. (2016). Barrier protective effects of 2, 4, 6-trihydroxy-3-geranyl acetophenone on lipopolysaccharides-stimulated inflammatory responses in human umbilical vein endothelial cells. Journal of ethnopharmacology, 192, 248-255.
  18. Ng, C. H., Rullah, K., Aluwi, M. F. F. M., Abas, F., Lam, K. W., Ismail, I. S., ... & Shaari, K. (2014). Synthesis and docking studies of 2, 4, 6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor. Molecules, 19(8), 11645-11659.

RESEARCH INTEREST

  • Drug Design & Synthesis (Ligand & Structure-based drug design; MD simulation of protein-ligand interaction for drug mechanistic study; SAR study to relate the physicochemical properties of a series of drugs to their biological activity.)
  • Natural Products Drug Discovery (Screening, isolation, and identification of natural enzyme inhibitors (NSAIDs, antioxidant, antidiabetic, antiaging) and anticancer compounds.)
  • Pharmaceutical & Cosmeceutical Design (Application of chemistry in pharmaceutical/cosmeceutical product development.)

RESEARCH PROJECT

National
  1. 2021 - 2024, Fundamental Research Grant Scheme (FRGS)
    Unravelling the effect of chalcone hybridization on LOX inhibitory properties of tHGA as an anti-asthmatic drug lead, through in vitro and in silico approaches ( Principal Investigator(PI))
  2. 2020 - 2024, Fundamental Research Grant Scheme (FRGS)
    Targeting Tropomyosin Receptor Kinase C Expressing Cancer Cells through Synthetic Ligand Conjugate and Cyclophosphamide for Immunotherapy ( Co-Researcher)
Private
  1. 2023 - 2025, MSU Seed Grant
    Comparative Studies of Antibacterial Activity Against Staphylococcus aureus and GC-MS Biocomponents Characterization of Eriobotrya japonica (loquat leaf) Residues from Semi-bionic and Ultrasonic Assisted Semi-bionic Extraction Methods. ( Principal Investigator(PI))
  2. 2023 - 2025, MSU Seed Grant
    Butterfly Blue Pea Flower and Neem Extract Combined Properties as Antibacterial Agent to Enhance Facial Skin Nourishment ( Co-Researcher)
  3. 2023 - 2024, MSU Publication and Conference Grant (MPCG)
    GCMS-Profiling, Formulation Characterization, and Molecular Docking of Citrus sinensis Peels Extract Loaded Lotion for Photoprotection. ( Principal Investigator(PI))
  4. 2021 - 2023, MSU Seed Grant
    In-vitro and In-silico Evaluations on Anti-diabetic Activity of Ethanolic and Aqueous-ethanolic Extracts of Hibiscus sabdariffa Flower. ( Principal Investigator(PI))
  5. 2021 - 2023, MSU Seed Grant
    In-vitro Synergistic Effects of Camellia sinensis and Allium sativum against Skin Pathogen Propionibacterium acnes for an Antiacne Topical Cosmeceutical Formulation. ( Principal Investigator(PI))
  6. 2019 - 2020, MSU Seed Grant
    Design, Synthesis, and In-silico Studies on 2,4,6-trihydroxy-3-geranyl-acetophenone analogues, an Antiasthma Natural Product Compound. ( Principal Investigator(PI))
  7. 2019 - 2020, MSU Seed Grant
    In-vitro Photoprotective Effects of Antioxidant-rich Carotenoids from Fruit's peels Extracts and its Potential for Sunscreen Lotion. ( Principal Investigator(PI))
  8. 2018 - 2020, MSU Seed Grant
    Synthesis, Characterization and Toxicity Properties of Metal Oxide Nanoparticles from Sargassum Brown Seaweed Extract ( Co-Researcher)
  9. 2018 - 2019, MSU Seed Grant
    Optimization of Extraction Parameters for Improving Biological Activities of Natural Product Plant Extracts ( Principal Investigator(PI))
  10. 2018 - 2019, MSU Seed Grant
    Zebrafish Embryo and Chick Chorioallantoic Membrane as Anticancer Drug Discovery Model. ( Co-Researcher)
International
  1. 2021 - 2022, International Funding
    A promising series of para-cinnamic acid derivatives as sunscreen and antioxidants: synthesis and activity ( Principal Investigator(PI))

PAPER PRESENTED

POSTER PRESENTER
  1. Photoprotective and antioxidant effects of Citrus limon and Citrus sinensis Peels: Comparative investigation of the efficiency of five extraction solvents., The Regional Conference & Exhibition on Natural Products Traditional Medicines and Herbs, Universiti Malaysia Sarawak (UNIMAS) (National) (09 Dec 2021 - 11 Dec 2021)
  2. Comparative Conventional Extraction Methods of Clinacanthus nutans on Antioxidant Activity and Toxicity, International Conference of Food Science and Nutrition, Management and Science University (International) (05 Dec 2019 - 06 Dec 2019)
  3. Synthesis and Docking Studies of 2,4,6-Trihydroxy-3-Geranylacetophenone Analogs as Potential Lipoxygenase Inhibitor, International Conference on Natural Products 2015, Universiti Teknologi Malaysia (UTM) (International) (24 Mar 2015 - 25 Mar 2015)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2024) Natural Product Research, International, (Reviewer)
  2. (2024) Pan-Genome Analysis and Identification of Potential Novel Drug Targets in Klebsiella Pneumoniae by Using Molecular Docking and Substractive Proteomics Approach, University, (Internal Examiner)
  3. (2023) Identification of Potential Drug Targets Candidates in Drug-Resistant Neisseria Gonorrhoeae Sp by Using Subtractive Genomic Approach, University, (Internal Examiner)
  4. (2023) Phytofabrication of Selenium Nanoparticles With Moringa Oleifera (Mo-Senps) and Exploring Its Antioxidant and Antidiabetic Potential, University, (Internal Examiner)
  5. (2021) Analysis of Marine Benthic Feeder Oil Extracts and Multivariate Data Analysis for Halal Authentication, University, (Internal Examiner)
Contribution to event
  1. (2022) Co-Program Director for 18th International Medical, Pharmaceutical, Cosmeceutical and Health Science Symposium (2022), University, (Event Coordinator)
  2. (2019) Co-Program Director for 12th International Medical, Pharmaceutical, Cosmeceutical and Health Science Symposium (2019), University, (Event Coordinator)
  3. (2018) Judge Invitation Committee for Perintis 2018, National, (Event Organiser)
  4. (2017) Publication Unit Leader for 9th Medical and Health Sciences Symposium (Mhss) (2017), University, (Event Coordinator)

SUPERVISION

Postgraduate Student
Master
  1. (2022) Unravelling the effect of chalcone hybridization on LOX inhibitory properties of tHGA as anti-asthmatic drug lead, through in vitro and in silico approaches, Raaginie A/P Tamil Segaran (Management and Science University (Msu), Malaysia)
  2. (2022) GCMS profiling, formulation characterization, and molecular docking of Citrus sinensis peels extract loaded lotion for photoprotection., Thong Poh Yen (Management and Science University (Msu), Malaysia)
Under Graduate Students
  1. (2024) Exploring the Potential Cyclin-Dependent Kinase 4 Inhibitors by Molecular Docking of GC-MS Separated Bioactive Constituents in Ganoderma Lucidum. (Management and Science University (Msu), Malaysia)
  2. (2023) Comparative studies of antibacterial activity against Staphylococcus aureus of Eriobotrya japonica (loquat leaf). (Management and Science University (Msu), Malaysia)
  3. (2023) GC-MS based metabolite & In-silico antidiabetic profiling of Hibiscus sabdariffa flower extract. (Management and Science University (Msu), Malaysia)
  4. (2023) GC-MS biocomponents characterization and in-silico antibacterial potency of Eriobotrya japonica (loquat leaf). (Management and Science University (Msu), Malaysia)
  5. (2022) GC-MS phytochemical profiling and in silico studies of Clinacanthus nutans leaves: A promising candidate antioxidant agent. (Management and Science University (Msu), Malaysia)
  6. (2022) Lead finding from plant Ganoderma lucidum based on pharmacokinetic properties: An in-silico approach. (Management and Science University (Msu), Malaysia)
  7. (2022) Systematic review of the conditions used for the extraction of anti-cancer compounds from Ganoderma lucidum. (Management and Science University (Msu), Malaysia)
  8. (2021) Photoprotective Effects of a Phytocosmetic Sunscreen Formulation Containing Ethyl Acetate Peel Extract of Citrus x Sinensis with Antioxidant Properties. (Management and Science University (Msu), Malaysia)
  9. (2021) Drug likeness rule and bioavailability score of the phytoconstituents present in Ganoderma lucidum. (Management and Science University (Msu), Malaysia)
  10. (2021) Biological and docking evaluation of para-cinnamic acid derivatives as promising antioxidant. (Management and Science University (Msu), Malaysia)
  11. (2021) In-Vitro Synergistic Effects of Camellia Sinensis and Allium Sativum Against Skin Pathogen Propionibacterium Acnes for an Antiacne Topical. (Management and Science University (Msu), Malaysia)
  12. (2020) Determination of molecular property, bioactivity score of the phytochemical compounds present in Astragalus genus plant using Molinspiration. (Management and Science University (Msu), Malaysia)
  13. (2020) Potential antidiabetic activity of aqueous-methanolic extracts from Annona muricata leaves by inhibition of alpha-glucosidase enzyme: In-silico and in-vitro approaches. (Management and Science University (Msu), Malaysia)
  14. (2020) In-vitro and In-silico evaluations on anti-diabetic activity of ethanolic and aqueous-ethanolic extracts of Hibiscus sabdariffa flowers (Management and Science University (Msu), Malaysia)
  15. (2020) Phenolic and Flavonoids compounds from Genus Phyllanthus as potential anti-collagenase: an in-silico comparative study for anti-aging application. (Management and Science University (Msu), Malaysia)
  16. (2020) Determination of molecular property, bioactivity score of the phytochemical compounds present in Lonicera japonica plant using Molinspiration. (Management and Science University (Msu), Malaysia)
  17. (2020) Exploring the potential anticancer compounds of Christia vespertilionis through in-silico studies: physiochemical profile and binding patterns with cyclin-dependent kinase (cdk). (Management and Science University (Msu), Malaysia)
  18. (2019) A review on phytochemical constituents and antibacterial activities from different parts of Lonicera japonica (honeysuckle). (Management and Science University (Msu), Malaysia)
  19. (2019) A review on comparison of the various methods for extraction of antibacterial compounds from Eriobotrya japonica (loquat leaf). (Management and Science University (Msu), Malaysia)
  20. (2019) Comparative evaluation of different Soxhlet extraction parameters for photoprotective activities from Andrographis paniculata: an in-vitro approach. (Management and Science University (Msu), Malaysia)
  21. (2019) Antibacterial and antioxidant strategies for acne treatment through extracts of garlics, green tea, and their combination. (Management and Science University (Msu), Malaysia)
  22. (2019) Photoprotective effects of Citrus limon peels: Comparative investigation of the efficiency of five extraction solvents. (Management and Science University (Msu), Malaysia)
  23. (2019) Photoprotective effects of Citrus x sinensis peels: Comparative investigation of the efficiency of five extraction solvents. (Management and Science University (Msu), Malaysia)
  24. (2019) In-silico studies on derivatives of 2,4,6-trihydroxy-3-geranyl-acetophenone, an antiasthma natural compound. (Management and Science University (Msu), Malaysia)
  25. (2018) Antibacterial potential of aqueous extracts and compounds from selected brown seaweeds. (Management and Science University (Msu), Malaysia)
  26. (2018) Antimibrobial potential of Padina australis and Sargassum polycystum against respiratory infections causing bacteria. (Management and Science University (Msu), Malaysia)
  27. (2018) TLC-autography guided screening for antioxidant activity component of Andrographis paniculata extracts from different soxhlet extraction parameters. (Management and Science University (Msu), Malaysia)
  28. (2018) Antifungal activity of successive extracts of Citrus limon peel for an antidandruff shampoo formulation. (Management and Science University (Msu), Malaysia)
  29. (2018) Evaluation of anticancer activity of Moringa oleifera leaves using vertebrate embryogenic model. (Management and Science University (Msu), Malaysia)
  30. (2018) A comparative study on different solvent extracts of Bougainvillea glabra choisy for antioxidant activity. (Management and Science University (Msu), Malaysia)
  31. (2018) Extraction of mangiferin of Leaves from Mangnifera indica as an active ingredient in sunscreen cream formulation. (Management and Science University (Msu), Malaysia)
  32. (2018) Evaluation of developmental toxicity and teratogenic induction of the organic extract of Bougainvillea glabra bracts using zebrafish embryos model for anticancer drug discovery. (Management and Science University (Msu), Malaysia)
  33. (2018) Toxicology evaluation of ethanolic extract of Clinacanthus nutans using both brine shrimp and zebrafish embryo assays. (Management and Science University (Msu), Malaysia)
  34. (2017) Toxicity effect of Bougainvillea glabra (paper flower) water extracts on zebrafish embryo. (Management and Science University (Msu), Malaysia)
  35. (2017) Optimization of the antioxidant extraction from leaves and bracts of Bougaainvillea glabra by using different polar solvents. (Management and Science University (Msu), Malaysia)
  36. (2017) Effects of extraction methods on antibacterial activity of Centella asiatica leaf against pathogenic gram positive and gram-negative bacteria. (Management and Science University (Msu), Malaysia)
  37. (2017) A study of conventional extraction methods on antioxidant and antibacterial activities of Clinacanthus nutans, a commonly consumed herb in tropical Asian countries. (Management and Science University (Msu), Malaysia)
  38. (2017) Optimization of Soxhlet extraction parameter for improving antimicrobial activity in vitro from Andrographis paniculata extracts. (Management and Science University (Msu), Malaysia)

PATENT/IPR

  • GCMS Profiling, Formulation Characterization, and Molecular Docking of Citrus sinensis Peels Extract Loaded Lotion for Photoprotection
    Copyright (National)

COURSE ATTENDED

External Course
NATIONAL
  1. Industrial Training Program 2011/2012 Session, Centre for Drug Research Universiti Sains Malaysia Pulau Pinang (04 Jul 2012 - 15 Sep 2012)
  2. Workshop on Docking & Molecular Dynamics Simulation, Malaysia Genome Institute (Mgi) (26 Jan 2016 - 28 Jan 2016)
INTERNATIONAL
  1. International Training Programme (Protein Sciences, Biochemistry, Cell and Molecular Biology, Medicinal Chemistry, DMPK, Pharmacology & Toxicology and Structural Biology), Aurigene Discovery Technologies Ltd. Bangalore, India (02 Jan 2013 - 08 Feb 2013)
  2. 18th Malaysian International Chemical Congress (18MICC) 2014, Pwtc, Kuala Lumpur, Malaysia (03 Nov 2014 - 05 Nov 2014)
  3. Drug and Vaccine Design in Era of Pandemic Satellite Virtual Symposium, International Conference On Drug Discovery and Translational Medicine 2021 (Icddtm21) (17 Nov 2020 - 17 Nov 2020)
  4. International Webinar "Drug Development for Combatting SARS-Cov-2", Surabaya, Indonesia (24 Nov 2020 - 24 Nov 2020)