Curriculum Vitae

DR. ASLINA BINTI PAHRUDIN ARROZI

Senior Lecturer
  • Department of Molecular Medicine
    Faculty of Medicine
  • aslina90
  • 03-79674912

BIOGRAPHY

Dr. Aslina Pahrudin Arrozi obtained her Bachelor of Science in Biochemistry from Universiti Kebangsaan Malaysia in 2013, followed by a Master's in Medical Science (Biochemistry) from the same university in 2018. Her dedication to expanding her knowledge led her to pursue studies in Japan under the Monbukagakusho (MEXT) scholarship from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. She successfully completed her PhD in Medical Science from Shiga University of Medical Science (SUMS), Japan, in 2022. Following this, she served as an assistant professor at the Molecular Neuroscience Research Center and Medical Innovation Research Center, SUMS, until September 2023 before joining Universiti Malaya as a Senior Lecturer at the Department of Molecular Medicine in November of the same year.

Her research focuses on the molecular mechanisms of neurodegenerative diseases and therapeutic potential of natural products. She aims to integrate biochemistry, neuroscience and pharmacology to develop therapies that not only prevent neurodegeneration but also enhance neuroprotection and improve cognitive health. As a young researcher, she has made significant contributions, publishing numerous articles in peer-reviewed journals and presenting her research at several national and international conferences. She remains dedicated to her passion for neuroscience and is eager to collaborate with interdisciplinary fields that share similar interests in the research area.

AREAS OF EXPERTISE

  • NATURAL PRODUCTS
    Neuroprotection
  • BIOCHEMISTRY
    Cellular signalling pathways
  • MOLECULAR NEUROSCIENCE
    Neurodegenerative diseases

ACADEMIC QUALIFICATION

  • PHD, (Medical Science)
    Shiga Unversity of Medical Science
  • MMedSci, (Medical Science)
    Universiti Kebangsaan Malaysia (UKM)
  • BSC, (BIOCHEMISTRY)
    Universiti Kebangsaan Malaysia (UKM)

ADMINISTRATIVE DUTIES

  • COMMITTEE MEMBER RESEARCH COMMUNICATION UNIT
    01 Mar 2024 - 31 Dec 2025 (Department of Molecular Medicine, Faculty of Medicine)
  • Assistant Deputy Quality Manager
    01 Jan 2024 - 31 Dec 2025 (Department)

MEMBERSHIPS

  • MALAYSIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, MEMBER
    2024 to present (National)
  • MALAYSIAN SOCIETY OF NEUROSCIENCE, ORDINARY MEMBER, MEMBER
    2024 to 2024 (National)
  • MALAYSIAN SOCIETY FOR NEUROSCIENCE, MEMBER
    2023 to 2023 (National)
  • JAPAN SOCIETY FOR DEMENTIA RESEARCH (JSDR), MEMBER
    2022 to 2023 (International)
  • JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY (JSHC), MEMBER
    2021 to 2022 (International)
  • JAPAN BRAIN SCIENCE SOCIETY (JBSS), MEMBER
    2019 to 2020 (International)

AWARD AND STEWARDSHIP

  • Young Investigator Exploratory Research
    Shiga University of Medical Science, President Research Expenditures, 2021 (University)
  • Recipient of Monbukagakusho (MEXT) Scholarship
    Ministry of Education, Culture, Sports, Science & Technology, 2018 (International)
  • Recipient of Zamalah Research University Scheme
    National University of Malaysia, 2016 (University)
  • Recipient of MyBrain 15 Scholarship
    Ministry of Higher Education, 2016 (National)
  • Best Poster Award, International Conference on Antioxidants & Degenerative Diseases
    International Conference on Antioxidants & Degenerative Diseases, 2015 (International)
  • Awarded Bachelor of Sciences with Honours (Biochemistry) [Distinction]
    National University of Malaysia, 2013 (University)
  • Recipient of Jabatan Perkhidmatan Awam (JPA) Scholarship
    Jabatan Perkhidmatan Awam Malaysia, 2013 (National)

PUBLICATIONS

Article in Journal
WoS
  1. Aldoghachi, Asraa Faris; Yanagisawa, Daijiro; Arrozi, Aslina Pahrudin; Bakar, Zulzikry Hafiz Abu; Taguchi, Hiroyasu; Ishigaki, Shinsuke; Morino, Katsutaro; Tooyama, Ikuo (2024). Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 694. doi:10.1016/j.bbrc.2023.149392
Others
  1. Pahrudin Arrozi A, Hamezah HS, Abu Bakar ZH, Yanagisawa D, Mihara K, Tooyama I. (2022). Effects of Ginseng Extract on AD-Related Cognitive decline in APP/PS1 mice. Geriatric Psychiatry Journal 33 (Special Issue-2) 258-258.
  2. Pahrudin Arrozi A, Shukri SNS, Mohd Murshid N, Ahmad Shahzalli AB, Wan Ngah WZ, Ahmad Damanhuri H and Makpol S. (2022). Alpha- and gamma-tocopherol modulates the amyloidogenic pathway of amyloid precursor protein in an in vitro model of Alzheimer’s disease: A transcriptional study. Frontiers in Cellular Neuroscience. 16:846459.
  3. Tada AM, Hamezah HS, Pahrudin Arrozi A, Abu Bakar ZH, Yanagisawa D, Tooyama I. (2022). Pharmaceutical potential of casein-derived tripeptide met-lys-pro: Improvement in cognitive impairments and suppression of inflammation in APP/PS1 Mice. Journal of Alzheimers disease. 1-14.
  4. Pahrudin Arrozi A, Abu Bakar ZH, Taguchi H, Yanagisawa D, Tooyama I. (2021). A fluorine-19 magnetic resonance probe, Shiga-Y5, downregulates thioredoxin-interacting protein expression in the brain of a mouse model of Alzheimer's disease. Molecules. 26(17).
  5. Pahrudin Arrozi A, Wan Ngah WZ, Ahmad Damanhuri MH, Makpol S. (2021). Modulatory effects of alpha-and gamma-tocopherol on the mitochondrial respiratory capacity and membrane potential in an in vitro model of Alzheimer's disease. Frontiers in Pharmacology. 12:698833.
  6. Pahrudin Arrozi A, Yanagisawa D, Kato T, Akatsu H, Hashizume Y, Kaneda D, and Tooyama I. (2021). Nasal extracts from patients with Alzheimer’s disease induce tau aggregates in a cellular model of tau propagation. Journal of Alzheimer’s disease Reports. 5(1):263-274.
  7. Yanagisawa D, Hamezah HS, Pahrudin Arrozi A. (2021). Differential accumulation of tau pathology between reciprocal F1 hybrids of rTg4510 mice. Scientific Reports. 11(1):9623.
  8. Pahrudin Arrozi A, Shukri SNS, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, & Makpol S. (2020). Comparative effects of alpha- and gamma-tocopherol on mitochondrial functions in Alzheimer's disease in vitro model. Scientific Reports. 10(1):8962.
  9. Pahrudin Arrozi A, Shukri SNS, Wan Ngah WZ, Yusof YA, Ahmad Damanhuri MH & Makpol S. (2017). Evaluation of the expression of amyloid precursor protein and the ratio of secreted amyloid beta 42 to amyloid beta 40 in SH-SY5Y cells stably transfected with wild-type, single-mutant and double-mutant forms of the APP gene for the study of Alzheimer's disease pathology. Applied Biochemistry Biotechnology. 183(3):853-866.
  10. Pahrudin Arrozi A, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, Makpol S. (2016). Antioxidant modulation in restoring mitochondrial function in neurodegeneration. International Journal of Neuroscience. 127(3):218-235.
Article in Proceeding
  1. Yanagisawa D, Arrozi AP, Kato T, Mizukami T, Akatsu H, Yoshio H, Kaneda D, Tooyama,I. (2024). Nasal tissues from Alzheimer’s disease patients induces the formation of aggregates in a cellular model of tau propagation. In Alzheimer's Association International Conference. ALZ.
  2. Pahrudin Arrozi A, Yanagisawa D, Kato T, Akatsu H, Hashizume Y, Kaneda D, Tooyama I. (2021). In vitro generation of tau aggregates derived from tau seed in nasal mucosa tissues of patients with Alzheimer's disease. The 62nd Annual Meeting of Japan Society of Histochemistry and Cytochemistry. 25-26 Sept 2021. Shiga, Japan.
  3. Pahrudin Arrozi A, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, Makpol S. (2017). Comparative effects of alpha- and gamma-tocopherol on the mitochondrial functions in SH-SY5Y stably transfected with wild -type, single -mutant (Swedish), and double-mutants (Swedish/Indiana) forms of APP gene. The 46th Annual Meeting of Japan Brain Science Society. 16 -17 Nov 2019. Shiga, Japan.
  4. Pahrudin Arrozi A, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, Makpol S. (2017). Effect Of A-and Y-tocopherol On The Expression Of Proteins Involved In Apoptosis Regulation In Sh-sy5y Stably Transfected With Wild, Single, And Double Mutant Forms Of App Gene. Palm International Nutra-cosmeceutical Conference. 31 July - 1 Aug 2017. Putrajaya, Malaysia.
  5. Pahrudin Arrozi A, Aminullah Lubis F, Wan Ngah WZ, ,Mohd Yusof A, Ahmad Damanhuri MH, Makpol S. (2015). Optimization of high-efficiency transfection of SH-SY5Y in vitro using eGFP reporter gene. International Conference on Antioxidant and Degenerative Diseases. 3-4 Jun 2015. Kuala Lumpur, Malaysia.

RESEARCH PROJECT

National
  1. 2024 - 2027, Fundamental Research Grant Scheme (FRGS)
    Elucidating The Role of Gut Microbiome and Its Metabolites in Alzheimer s Disease and Its Modulation by Tocotrienols, Ministry of Higher Education ( Co-Researcher)
University
  1. 2024 - 2027, UNIVERSITI MALAYA RESEARCH EXCELLENCE GRANT (UMREG)
    Elucidating the Neuroinflammation Modulatory Effects of Rhizome Extracts from Three Zingiber Species in an Alzheimer?s Disease Cell Model ( Principal Investigator(PI))

PAPER PRESENTED

ORAL PRESENTER
  1. Investigating the relationship between phosphorylated tau level in brain with tau aggregates level in cellular model of tau propagation., 51st Japan Brain Science Society Meeting, Japan Brain Science Society (International) (08 Nov 2024 - 09 Nov 2024)
  2. In vitro generation of tau aggregates derived from tau seed in nasal mucosa tissues of patients with Alzheimer's disease, The 62nd Annual Meeting of Japan Society of Histochemistry and Cytochemistry, Shiga University of Medical Science (International) (25 Sep 2021 - 26 Sep 2021)
  3. Cellular bioassay using nasal tissues as a potential diagnostic method for Alzheimer's disease, The 38th Shiga University of Medical Science Symposium, Shiga University of Medical Science (University) (07 Jul 2021 - 07 Jul 2021)
  4. Comparative effects of alpha- and gamma-tocopherol on the mitochondrial functions in SH-SY5Y stably transfected with wild -type, single -mutant (Swedish), and double-mutants (Swedish/Indiana) forms of APP gene, The 46th Annual Meeting of Japan Brain Science Society, Shiga University of Medical Science (International) (16 Nov 2019 - 17 Nov 2019)
  5. Tocopherol isomers modulation on mitochondrial function in stably transfected SH-SY5Y with wild and mutant APP gene, Research Update Series, UKM Molecular Biology Institute (University) (02 Jun 2016 - 02 Jun 2016)
  6. Development of SH-SY5Y neuroblastoma cell lines expressing APP wild and mutant types for the study of amyloid-beta pathology, International Postgraduate Research Award Seminar, University of Malaya and The Malaysian Society for Molecular Biology and BIotechnology (National) (07 Mar 2016 - 08 Mar 2016)
  7. Tocopherol isomers modulation on mitochondrial function in stably transfected SH-SY5Y with wild and mutant APP gene, Research Update Series, UKM Molecular Biology Institute (UMBI) (University) (04 Jun 2015 - 04 Jun 2015)
POSTER PRESENTER
  1. Nasal tissues from Alzheimer s disease patients induces the formation of aggregates in a cellular model of tau propagation, Alzheimer's Association International Conference, Alzheimer's Association (International) (28 Jul 2024 - 01 Aug 2024)
  2. Effects of ginseng extract on AD-related cognitive decline in APP/PS1 mice, The 41st Annual Meeting of the Japan Society for Dementia and The 37th Annual Meeting of the Japan Society for Geriatric Psychiatry, Japan Society for Dementia Research and Japan Society for Geriatric Psychiatry (International) (25 Nov 2022 - 27 Nov 2022)
  3. Effects of alpha- and gamma-tocopherol on the expression of the proteins involved in apoptosis regulation in SH-SY5Y stably transfected with wild, single and double mutant forms of APP gene, Palm International Nutra-cosmeceutical Conference, Malaysian Palm Oil Council (National) (31 Jul 2017 - 01 Aug 2017)
  4. Optimization of high-efficiency transfection of SH-SY5Y in vitro using eGFP reporter gene, International Conference on Antioxidant and Degenerative Diseases, Department of Biochemistry, Faculty of Medicine, National University of Malaysia (National) (03 Jun 2015 - 04 Jun 2015)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2024) Investigation of Ligno-Tm02 as Adjunctive Therapeutics for Respiratory Diseases, University, (Reviewer)
  2. (2024) 3 Minute Thesis (3mt), Research Methodology Course Evaluator, Sem 2, 2023/2024, University, (Internal Examiner)
  3. (2023) 3 Minute Thesis (3mt), Research Methodology Course Evaluator Sem 1, 2023/2024, University, (Internal Examiner)