CURRICULUM VITAE
BIOGRAPHY
Dr. Aslina Pahrudin Arrozi is a Senior Lecturer in the Department of Molecular Medicine at Universiti Malaya, leading translational research at the intersection of molecular neuroscience, molecular pathology, and cognitive health. She earned her BSc in Biochemistry (2013) and Master’s in Medical Science (2018) from Universiti Kebangsaan Malaysia (UKM), followed by a PhD in Medical Science (2022) from Shiga University of Medical Science (SUMS), Japan, under the MEXT scholarship. After serving as an Assistant Professor at Molecular Neuroscience Research Centre (SUMS), she joined Universiti Malaya in late 2023.
Her research addresses brain health across the lifespan from the molecular pathology of neurodegeneration in aging to cognitive development. She specializes in evaluating natural bioactive compounds (Zingiber extracts, vitamin E isomers, peptides, etc) to mitigate neuroinflammation, glial activation, and amyloid/tau pathology in Alzheimer’s disease and related tauopathies. Anchored in molecular neuroscience and molecular pathology, her research program integrates fundamental cell biology, cross-system physiology, bioenergetics, and functional neuro-assessments. By investigating how systemic metabolic signals, cellular stress, and mitochondrial dysfunction drive neurodegeneration, alongside evaluating cognitive performance, her lab serves as a versatile translational testing platform. Dr. Aslina actively seeks multidisciplinary collaborations with natural product chemists, bioengineers, data scientists, and clinical trialists to translate core mechanistic insights into innovative neuroprotective therapies, diagnostic biomarkers, and targeted brain interventions across diverse age-related brain disorders.
AREAS OF EXPERTISE
- NEUROBIOCHEMISTRYMedical And Health Sciences, Medical Sciences, Neurosciences
- PHARMACOLOGY OF NATURAL PRODUCTSMedical And Health Sciences, Medical Sciences, Medical Pharmacology
ACADEMIC QUALIFICATION
- PHD, (Medical Science)Shiga Unversity of Medical Science
- MMedSci, (Medical Science)Universiti Kebangsaan Malaysia (UKM)
- BSC, (BIOCHEMISTRY)Universiti Kebangsaan Malaysia (UKM)
ADMINISTRATIVE DUTIES
- ASSISTANT DEPUTY QUALITY MANAGER01 Jan 2026 - 01 Mar 2028 (Department)
- DEPARTMENT SEMINAR COMMITTEE MEMBER AND MOMPES ADVISOR01 Jan 2026 - 01 Mar 2028 (Department)
- COMMITTEE MEMBER RESEARCH COMMUNICATION UNIT (RCU)01 Jan 2026 - 31 Dec 2027 (Department of Molecular Medicine, Faculty of Medicine)
- COMMITTEE MEMBER RESEARCH COMMUNICATION UNIT01 Mar 2024 - 31 Dec 2025 (Department of Molecular Medicine, Faculty of Medicine)
- Assistant Deputy Quality Manager01 Jan 2024 - 31 Dec 2025 (Department)
- Coordinator01 Aug 2024 - 31 Dec 2025 (Department)
MEMBERSHIPS
- MALAYSIAN SOCIETY OF NEUROSCIENCES, MEMBER2024 to 2026 (National)
- MALAYSIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, MEMBER2024 to 2026 (National)
- JAPAN SOCIETY FOR DEMENTIA RESEARCH (JSDR), MEMBER2022 to 2023 (International)
- JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY (JSHC), MEMBER2021 to 2022 (International)
- JAPAN BRAIN SCIENCE SOCIETY (JBSS), MEMBER2019 to 2020 (International)
AWARD AND STEWARDSHIP
- Young Investigator Exploratory Research2021, Shiga University of Medical Science, President Research Expenditures, University
- Recipient of Monbukagakusho (MEXT) Scholarship2018, Ministry of Education, Culture, Sports, Science & Technology, International
- Recipient of Zamalah Research University Scheme2016, National University of Malaysia, University
- Recipient of MyBrain 15 Scholarship2016, Ministry of Higher Education, National
- Best Poster Award, International Conference on Antioxidants & Degenerative Diseases2015, International Conference on Antioxidants & Degenerative Diseases, International
- Awarded Bachelor of Sciences with Honours (Biochemistry) [Distinction]2013, National University of Malaysia, University
- Recipient of Jabatan Perkhidmatan Awam (JPA) Scholarship2013, Jabatan Perkhidmatan Awam Malaysia, National
PUBLICATIONS
Article in Journal
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Nazar, FH; Arrozi, AP; Kato, T; Yanagisawa, D; Itoh, Y; Tooyama, I; Bellier, JP (2026). Nuclear Speckle Protein SRRM2 Co-localized with Pathological Tau (pTauS396) in Neuronal and Glial Cells in Progressive Supranuclear Palsy, ACTA HISTOCHEMICA ET CYTOCHEMICA. 59, 11. doi:10.1267/ahc.26-00005
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Aldoghachi, Asraa Faris; Yanagisawa, Daijiro; Arrozi, Aslina Pahrudin; Bakar, Zulzikry Hafiz Abu; Taguchi, Hiroyasu; Ishigaki, Shinsuke; Morino, Katsutaro; Tooyama, Ikuo (2024). Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 694. doi:10.1016/j.bbrc.2023.149392
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Ramli, Nur Zuliani; Yahaya, Mohamad Fairuz; Fahami, Nur Azlina Mohd; Hamezah, Hamizah Shahirah; Abu Bakar, Zulzikry Hafiz; Arrozi, Aslina Pahrudin; Yanagisawa, Daijiro; Tooyama, Ikuo; Singh, Meharvan; Damanhuri, Hanafi Ahmad (2024). Spatial learning and memory impairment at the post-follicular depletion state is associated with reduced hippocampal glucose uptake, EXPERIMENTAL GERONTOLOGY. 197. doi:10.1016/j.exger.2024.112607
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Pahrudin Arrozi A, Hamezah HS, Abu Bakar ZH, Yanagisawa D, Mihara K, Tooyama I. (2022). Effects of Ginseng Extract on AD-Related Cognitive decline in APP/PS1 mice. Geriatric Psychiatry Journal 33 (Special Issue-2) 258-258.
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Pahrudin Arrozi A, Shukri SNS, Mohd Murshid N, Ahmad Shahzalli AB, Wan Ngah WZ, Ahmad Damanhuri H and Makpol S. (2022). Alpha- and gamma-tocopherol modulates the amyloidogenic pathway of amyloid precursor protein in an in vitro model of Alzheimer’s disease: A transcriptional study. Frontiers in Cellular Neuroscience. 16:846459.
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Tada AM, Hamezah HS, Pahrudin Arrozi A, Abu Bakar ZH, Yanagisawa D, Tooyama I. (2022). Pharmaceutical potential of casein-derived tripeptide met-lys-pro: Improvement in cognitive impairments and suppression of inflammation in APP/PS1 Mice. Journal of Alzheimers disease. 1-14.
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Pahrudin Arrozi A, Abu Bakar ZH, Taguchi H, Yanagisawa D, Tooyama I. (2021). A fluorine-19 magnetic resonance probe, Shiga-Y5, downregulates thioredoxin-interacting protein expression in the brain of a mouse model of Alzheimer's disease. Molecules. 26(17).
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Pahrudin Arrozi A, Wan Ngah WZ, Ahmad Damanhuri MH, Makpol S. (2021). Modulatory effects of alpha-and gamma-tocopherol on the mitochondrial respiratory capacity and membrane potential in an in vitro model of Alzheimer's disease. Frontiers in Pharmacology. 12:698833.
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Pahrudin Arrozi A, Yanagisawa D, Kato T, Akatsu H, Hashizume Y, Kaneda D, and Tooyama I. (2021). Nasal extracts from patients with Alzheimer’s disease induce tau aggregates in a cellular model of tau propagation. Journal of Alzheimer’s disease Reports. 5(1):263-274.
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Yanagisawa D, Hamezah HS, Pahrudin Arrozi A. (2021). Differential accumulation of tau pathology between reciprocal F1 hybrids of rTg4510 mice. Scientific Reports. 11(1):9623.
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Pahrudin Arrozi A, Shukri SNS, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, & Makpol S. (2020). Comparative effects of alpha- and gamma-tocopherol on mitochondrial functions in Alzheimer's disease in vitro model. Scientific Reports. 10(1):8962.
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Pahrudin Arrozi A, Shukri SNS, Wan Ngah WZ, Yusof YA, Ahmad Damanhuri MH & Makpol S. (2017). Evaluation of the expression of amyloid precursor protein and the ratio of secreted amyloid beta 42 to amyloid beta 40 in SH-SY5Y cells stably transfected with wild-type, single-mutant and double-mutant forms of the APP gene for the study of Alzheimer's disease pathology. Applied Biochemistry Biotechnology. 183(3):853-866.
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Pahrudin Arrozi A, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, Makpol S. (2016). Antioxidant modulation in restoring mitochondrial function in neurodegeneration. International Journal of Neuroscience. 127(3):218-235.
Article in Proceeding
- Nazar FH, Kato T , Pahrudin Arrozi A, Yanagisawa D , Bellier JP, Itoh Y , Tooyama I. (2025). SRRM2 is localized to tau aggregates in the brain of PSP. Japan Society for Dementia Research. JSDR
- Yanagisawa D, Arrozi AP, Kato T, Mizukami T, Akatsu H, Yoshio H, Kaneda D, Tooyama,I. (2024). Nasal tissues from Alzheimer’s disease patients induces the formation of aggregates in a cellular model of tau propagation. In Alzheimer's Association International Conference. ALZ.
- Pahrudin Arrozi A, Yanagisawa D, Kato T, Akatsu H, Hashizume Y, Kaneda D, Tooyama I. (2021). In vitro generation of tau aggregates derived from tau seed in nasal mucosa tissues of patients with Alzheimer's disease. The 62nd Annual Meeting of Japan Society of Histochemistry and Cytochemistry. 25-26 Sept 2021. Shiga, Japan.
- Pahrudin Arrozi A, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, Makpol S. (2017). Comparative effects of alpha- and gamma-tocopherol on the mitochondrial functions in SH-SY5Y stably transfected with wild -type, single -mutant (Swedish), and double-mutants (Swedish/Indiana) forms of APP gene. The 46th Annual Meeting of Japan Brain Science Society. 16 -17 Nov 2019. Shiga, Japan.
- Pahrudin Arrozi A, Wan Ngah WZ, Mohd Yusof YA, Ahmad Damanhuri MH, Makpol S. (2017). Effect Of A-and Y-tocopherol On The Expression Of Proteins Involved In Apoptosis Regulation In Sh-sy5y Stably Transfected With Wild, Single, And Double Mutant Forms Of App Gene. Palm International Nutra-cosmeceutical Conference. 31 July - 1 Aug 2017. Putrajaya, Malaysia.
- Pahrudin Arrozi A, Aminullah Lubis F, Wan Ngah WZ, ,Mohd Yusof A, Ahmad Damanhuri MH, Makpol S. (2015). Optimization of high-efficiency transfection of SH-SY5Y in vitro using eGFP reporter gene. International Conference on Antioxidant and Degenerative Diseases. 3-4 Jun 2015. Kuala Lumpur, Malaysia.
Other Publications
- Arrozi A, Ayob AZ & Hamid MHBA. Halia dan Sistem Imun dalam Mencegah Kanser. Majalah Sains. https://www.majalahsains.com/halia-dan-sistem-imun-dalam-mencegah-kanser/ - Mass Media(newspaper,radio,tv,popular Magazine)
- Mahmud, N. M., Ayob, A. Z., & Arrozi, A. P. (2025, December 7). Peranan makmal universiti ke arah kampus lestari: Apa itu Green Lab? MajalahSains. https://www.majalahsains.com/peranan-makmal-universiti-ke-arah-kampus-lestari-apa-itu-green-lab/ - Mass Media(newspaper,radio,tv,popular Magazine)
RESEARCH INTEREST
- Molecular Pathology of Neurodegeneration (Neurodegenerative diseases eg: Alzheimer's)
- Neuroinflammation & Glial Activation (Neuroinflammation)
- Translational Neuropharmacology (Natural products)
- Mitochondrial Biology & Bioenergetics (Mitochondrial dysfunction)
- Brain Aging & Geroscience (Ageing)
- Cognitive Neuroscience (Memory & Learning)
RESEARCH PROJECT
National
- 2026 - 2028, UM MATCHING GRANT ? PRIVATEIntegrative Assessment Of Cognitive Performance And Eeg Measures Following A Multi-component Memory Training Program In Typically Developing Children Aged 7?12 ( Principal Investigator(PI))
- 2024 - 2027, UNIVERSITI MALAYA RESEARCH EXCELLENCE GRANT (UMREG)Elucidating The Neuroinflammation Modulatory Effects Of Rhizome Extracts From Three Zingiber Species In An Alzheimer?s Disease Cell Model ( Principal Investigator(PI))
- 2024 - 2027, Fundamental Research Grant Scheme (FRGS)Elucidating The Role of Gut Microbiome and Its Metabolites in Alzheimer s Disease and Its Modulation by Tocotrienols, Ministry of Higher Education ( Co-Researcher)
Private
- 2026 - 2028, Private FundingImplementation And Evaluation Of A Multi-component Memory Training Program On Cognitive Performance And Eeg Measures In Typically Developing Children Aged 7?12 ( Principal Investigator(PI))
- 2026 - 2026, Seed GrantCharacterising Nuclear Factor-Kappa B (NF- B) Mediated Neuroinflammatory Mechanisms in Human Microglia: A Preclinical Model Relevant to Autism Spectrum Disorder., Monash University Malaysia campus ( Co-Researcher)
PAPER PRESENTED
Invited Speaker
- Tau Pathology and Propagation in Alzheimer s: Insights from Nasal Tau Seeding and the Correlation Between Phosphorylated Tau and Brain Tau Seeding, The 24th Annual Meeting of Infantile Seizure Society In conjunction with The 33rd Malaysian Society of Neurosciences Annual Scientific Meeting (MSN 2025) AND 7TH BRaINS | BNC Research and Innovations in Neuroscience, Infantile Seizure Society and Malaysian Society for Neuroscience (International) (17 Jul 2025 - 19 Jul 2025)
Oral Presenter
- Investigating the relationship between phosphorylated tau level in brain with tau aggregates level in cellular model of tau propagation., 51st Japan Brain Science Society Meeting, Japan Brain Science Society (International) (08 Nov 2024 - 09 Nov 2024)
- In vitro generation of tau aggregates derived from tau seed in nasal mucosa tissues of patients with Alzheimer's disease, The 62nd Annual Meeting of Japan Society of Histochemistry and Cytochemistry, Shiga University of Medical Science (International) (25 Sep 2021 - 26 Sep 2021)
- Cellular bioassay using nasal tissues as a potential diagnostic method for Alzheimer's disease, The 38th Shiga University of Medical Science Symposium, Shiga University of Medical Science (University) (07 Jul 2021 - 07 Jul 2021)
- Comparative effects of alpha- and gamma-tocopherol on the mitochondrial functions in SH-SY5Y stably transfected with wild -type, single -mutant (Swedish), and double-mutants (Swedish/Indiana) forms of APP gene, The 46th Annual Meeting of Japan Brain Science Society, Shiga University of Medical Science (International) (16 Nov 2019 - 17 Nov 2019)
- Tocopherol isomers modulation on mitochondrial function in stably transfected SH-SY5Y with wild and mutant APP gene, Research Update Series, UKM Molecular Biology Institute (University) (02 Jun 2016 - 02 Jun 2016)
- Development of SH-SY5Y neuroblastoma cell lines expressing APP wild and mutant types for the study of amyloid-beta pathology, International Postgraduate Research Award Seminar, University of Malaya and The Malaysian Society for Molecular Biology and BIotechnology (National) (07 Mar 2016 - 08 Mar 2016)
- Tocopherol isomers modulation on mitochondrial function in stably transfected SH-SY5Y with wild and mutant APP gene, Research Update Series, UKM Molecular Biology Institute (UMBI) (University) (04 Jun 2015 - 04 Jun 2015)
Poster Presenter
- Nuclear Speckle Protein SRRM2 Co-localized with Pathological Tau (pTauS396) in Progressive Supranuclear Palsy (PSP) Neurons and Glia, The 42th SUMS Symposium - Legacy and Evolution: Collaborating for the Next Fifty Years, Shiga University of Medcial Science (International) (25 Nov 2025 - 25 Dec 2025)
- SRRM2 is localized to tau aggregates in the brain of PSP, The 44th Annual Meeting of Japan Society Dementia Research, Japan Society for Dementia Research (International) (21 Nov 2025 - 23 Nov 2025)
- Nasal tissues from Alzheimer s disease patients induces the formation of aggregates in a cellular model of tau propagation, Alzheimer's Association International Conference, Alzheimer's Association (International) (28 Jul 2024 - 01 Aug 2024)
- Effects of ginseng extract on AD-related cognitive decline in APP/PS1 mice, The 41st Annual Meeting of the Japan Society for Dementia and The 37th Annual Meeting of the Japan Society for Geriatric Psychiatry, Japan Society for Dementia Research and Japan Society for Geriatric Psychiatry (International) (25 Nov 2022 - 27 Nov 2022)
- Effects of alpha- and gamma-tocopherol on the expression of the proteins involved in apoptosis regulation in SH-SY5Y stably transfected with wild, single and double mutant forms of APP gene, Palm International Nutra-cosmeceutical Conference, Malaysian Palm Oil Council (National) (31 Jul 2017 - 01 Aug 2017)
- Optimization of high-efficiency transfection of SH-SY5Y in vitro using eGFP reporter gene, International Conference on Antioxidant and Degenerative Diseases, Department of Biochemistry, Faculty of Medicine, National University of Malaysia (National) (03 Jun 2015 - 04 Jun 2015)
ACADEMIC/ PROF. SERVICES
Evaluation
- (2025) Penilaian Dalaman Bagi Permohonan Skim Geran Padanan UM-ucsi 2025, University, (Reviewer)
- (2025) Investigating The Molecular and Biochemical Signatures of Ferroptosis in Heart Failure With Preserved Ejection Fraction, University, (Internal Examiner)
- (2025) Investigation of Ligno-tm02® as Adjunctive Therapeutics for Respiratory Diseases, University, (Internal Examiner)
- (2025) Peerj, International, (Reviewer)
- (2025) 3 Minute Thesis (3mt), Research Methodology Course Evaluator, Sem 2, 2024/2025, University, (Internal Examiner)
- (2025) Tropical Journal of Natural Product Research (tjnpr), International, (Reviewer)
- (2024) Malaysian Journal of Biochemistry and Molecular Biology, National, (Reviewer)
- (2024) Investigation of Ligno-tm02 as Adjunctive Therapeutics for Respiratory Diseases, University, (Reviewer)
- (2024) 3 Minute Thesis (3mt), Research Methodology Course Evaluator, Sem 2, 2023/2024, University, (Internal Examiner)
- (2023) 3 Minute Thesis (3mt), Research Methodology Course Evaluator Sem 1, 2023/2024, University, (Internal Examiner)
SUPERVISION
Postgraduate Student
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(2025) Elucidating the role of gut microbiome and its metabolites in Alzheimer's disease animal model and its modulation by tocotrienol., Nurin Iffah Binti Ely Arman (Universiti Kebangsaan Malaysia (UKM))
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(2025) ELUCIDATING THE NEUROINFLAMMATION-MODULATING EFFECTS OF SUBCRITICAL WATER EXTRACTS FROM ZINGIBER SPECIES IN AN ALZHEIMER’S DISEASE CELL MODEL, CARMEL CHUAH PAO EAH
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(2025) EVALUATION OF THE EFFECTS OF A MULTI-COMPONENT MEMORY TRAINING PROGRAMME ON COGNITIVE PERFORMANCE AND EEG MEASURES IN TYPICALLY DEVELOPING CHILDREN AGED 7–12, CHEE PUI KHEI
TEACHING
Bachelor
- (2024) DIA1003 - Biochemistry
- (2024) GDM0006 - Global Trends in Food and Health
- (2024) MIA 2001 - Universiti Malaya Medical Programme (ummp)
Full-Time Equivalent (FTE)
- (2025) DFEX1000 - First Year Professional Examination
- (2025) GQM0079 - Global Trends in Food and Human Health
- (2026) GQM0079 - Global Trends in Food and Human Health
- (2025) GQM0084 - Global Lifestyle Diseases and Prevention
- (2026) GQM0084 - Global Lifestyle Diseases and Prevention