Curriculum Vitae

PERSONAL DETAILS

ASSOCIATE PROF. DR. KAMAL AZRIN BIN ABDULLAH @ KALAI ARASU A/L MUTHUSAMY


BIOGRAPHY
I, Dr Kalai Arasu Muthusamy am a Senior Lecturer and Consultant Neurosurgeon at the University Malaya Medical Centre, Kuala Lumpur. I earned my medical degree (MBBS) at The University Of Malaya in 1995. I completed my 4 years of General Surgical Training and started my Neurosurgical training at University Malaya Medical Centre in 2002. I underwent subspecialty training in Functional Neurosurgery and Movement Disorders under Professor Tipu Aziz (a world authority in the field of Functional Neurosurgery and Deep Brain Stimulation) at Functional Neurosurgery group, Oxford University. Under the guidance of Professor Tipu Aziz and Professor John Stein (a senior Neuroscientist at Oxford University and a world authority on Dyslexia), I received my DPhil (Oxon) from the University of Oxford and completed my training in Functional Neurosurgery in 2009. My research focused mainly on the advanced Parkinson s symptoms such as akinesia and the role of Pedunculopontine Nucleus in movement disorder. I also worked out the connectivity of the peduncolopontine connectivity in humans and non-human primates and their role in movement disorder. I have numerous publications in international medical journals mainly on the role of PPN in movement disorder as stated in my CV.
ADMINISTRATIVE DUTIES
(Role),(Level),(Duration)
  • HEAD OF UNIT, Faculty, 01/01/2021 to 31/12/2021
  • HEAD OF UNIT, Faculty, 01/12/2018 to 17/01/2021
  • Pemantau Medical Report, Faculty, 16/12/2009 to present
  • CFCS with the primary care department, Faculty, 01/12/2009 to present
  • Final MBBS surgical cordinator 2010, Faculty, 22/11/2009 to present
  • E-precipitation in Surgical Outpatient clinic ,University Malaya Medical Centre 2005., Faculty, 01/01/2005 to present
  • Surgical Coordinator for Repeater & Unscheduled University students 3rd MBBS Final examination 2004, Faculty,   to present
  • Surgical Coordinator for 3rd MBBS final examination 2004. , Faculty,   to present
ACADEMIC QUALIFICATION
(Qualification),(Field),(Institution),(Year)
  • D.PHIL (OXON), MEDICINE, OXFORD UNIVERSITY, OXFORD, UK
  • MSURGERY(UM), SURGERY, UNIVERSITI MALAYA (UM)
  • MBBS(UM), MEDICINE AND SURGERY, UNIVERSITI MALAYA (UM)
MEMBERSHIPS
(Organisation),(Role),(Duration),(Level)
  • Member of Malaysian Medical Association, Life Member, Since 2019 (National)
  • Oxford alumi, Wolfson, Member, Since 2009 (International)
  • Malaysian society of Neurosciences., Life Member, Since 2004 (National)
  • Neurosurgical Association of Malaysia , Member, Since 2003 (National)
SPECIALIZATION
(Area)
Area of Expertise
  • Neuromodulation; Deep Brain Stimulation (Neuro modulation, Deep Brain stimulation, Parkinson's Disease)
  • INTENSIVE CARE (Neuro intensive care)
  • Neuromodulation (Deep Brain Surgery) (Neuromodulation (Deep Brain Stimulation))
  • Neurosurgery (Functional Neurosurgery)
  • MAGNETIC RESONANCE IMAGING(MRI) (DTI and Tractography)
  • CENTRAL NERVOUS SYSTEM (Primate Research in Movement Disorder)
    • Research Interest
  • Parkinson's Disaese and other movement disorders (Parkinson disease)
  • Deep Brain Stimulation (DBS)
  • Neuro Intensive care (Neuro ICU)
  • Dyslexia Reserch & reading difficulty (Dyslexia)
    • TEACHING
    (Course Title),(Level of Study),(Institution),(Academic Session)
    Teaching
  • Neurosurgical Teaching Phase 3B in Klang, First Degree, UNIVERSITY MALAYA (2009/2010 - )
  • General Surgical teaching in Banting Hosp. Phase 3A, First Degree, UNIVERSITY MALAYA (2010/2011 - )
    • PUBLICATIONS
    (Title of publication in APA style)
    WoS
    2022
    • Lim, JL; Lohmann, K; Tan, AH; Tay, YW; Ibrahim, KA; Aziz, ZA; Mawardi, AS; Puvanarajah, SD; Lim, TT; Looi, I; Ooi, JCE; Chia, YK; Muthusamy, KA; Bauer, P; Rolfs, A; Klein, C; Ahmad-Annuar, A; Lim, SY (2022). Glucocerebrosidase (GBA) gene variants in a multi-ethnic Asian cohort with Parkinson's disease: mutational spectrum and clinical features, JOURNAL OF NEURAL TRANSMISSION. (), . doi:10.1007/s00702-021-02421-0
    2020
    • Lim, S. Y., Lim, J. L., Ahmad-Annuar, A., Lohmann, K., Tan, A. H., Lim, K. B., . . . Klein, C. (2020). Clinical Phenotype ofLRRK2R1441C in 2 Chinese Sisters. Neurodegenerative Diseases, 20(1), 39-45. doi: 10.1159/000508131
    Scopus
    2022
    • Goo Z.Q., Muthusamy K.A. (2022). Early versus standard tracheostomy in ventilated patients in neurosurgical intensive care unit: A randomized controlled trial, Journal of Clinical Neuroscience. 98(), 162-167. doi:10.1016/j.jocn.2022.02.011
    • Lim J.L., Lohmann K., Tan A.H., Tay Y.W., Ibrahim K.A., Abdul Aziz Z., Mawardi A.S., Puvanarajah S.D., Lim T.T., Looi I., Ooi J.C.E., Chia Y.K., Muthusamy K.A., Bauer P., Rolfs A., Klein C., Ahmad-Annuar A., Lim S.Y. (2022). Glucocerebrosidase (GBA) gene variants in a multi-ethnic Asian cohort with Parkinson s disease: mutational spectrum and clinical features, Journal of Neural Transmission. 129(1), 37-48. doi:10.1007/s00702-021-02421-0
    Refereed Journals
    2022
    • Goo, Zhen Qiang, Muthusamy, Kalai Arasu (2022). Early Versus Standard Tracheostomy in Ventilated Patients in Neurosurgical Intensive Care Unit: A Randomized Controlled Trial.
    2021
    • Andrew Charles Gomez Junior, Chong Aun Wee, Mohd Adzreil Bin Bakri, Kamal Azrin Abdullah @ Kalai Arasu Muthusamy, Lim Shen-Yang,. The effects of subthalamic nucleus deep brain stimulation on sleep quality and polysomnographic parameters in patients with Parkinson s disease.Med J Malaysia Vol 76 Supplement 1 June 2021, OP 20, Pg 21.
    • Lim, J.L., Lohmann, K., Tan, A.H. et al. Glucocerebrosidase (GBA) gene variants in a multi-ethnic Asian cohort with Parkinson s disease: mutational spectrum and clinical features. J Neural Transm (2021). https://doi.org/10.1007/s00702-021-02421-0
    2020
    • Lim, S. Y., Lim, J. L., Ahmad-Annuar, A., Lohmann, K., Tan, A. H., Lim, K. B., ... & Rolfs, A. (2020). Clinical Phenotype of LRRK2 R1441C in 2 Chinese Sisters. Neurodegenerative Diseases, 1-7. (WoS)
    2018
    • A Review of the Pedunculopontine Nucleus in Parkinson's Disease. French IT, Muthusamy KA. Front Aging Neurosci. 2018 Apr 26;10:99. doi: 10.3389/fnagi.2018.00099. eCollection 2018. Review. (WoS)
    2016
    • Isobel T. French and Kalai A. Muthusamy. A REVIEW OF SLEEP AND ITS DISORDERS IN PATIENTS WITH PARKINSON'S DISEASE IN RELATION TO VARIOUS BRAIN STRUCTURES. Front. Aging Neurosci. | doi: 10.3389/fnagi.2016.00114 (WoS)
    • A Review of Sleep and Its Disorders in Patients with Parkinson's Disease in Relation to Various Brain Structures. French IT, Muthusamy KA. Front Aging Neurosci. 2016 May 23;8:114. doi: 10.3389/fnagi.2016.00114. eCollection 2016. Review. (WoS)
    2015
    • Simul Healthc. 2015 Feb;10(1):43-8. doi: 10.1097/SIH.0000000000000060. Neurosurgical endoscopic training via a realistic 3-dimensional model with pathology. Waran V1, Narayanan V, Karuppiah R, Thambynayagam HC, Muthusamy KA, Rahman ZA, Kirollos RW. (WoS)
    • Waran, V., Narayanan, V., Karuppiah, R., Thambynayagam, H. C., Muthusamy, K. A., Rahman, Z. A. A., Kirollos, R. W. 2015. Neurosurgical Endoscopic Training via a Realistic 3-Dimensional Model With Pathology Simulation in Healthcare-Journal of the Society for Simulation in Healthcare (WoS)
    2014
    • Norlisah Ramli , Farhana Fadzli , Kalai Arasu Muthusamy , Chan Kam Hong. Multiloculated hydrocephalus in an adult: Role of MRI FIESTA sequence in diagnosis and management.Neurology Asia 2014; 19(4) : 425- 427 (WoS)
    2013
    • Parameswari Shunmugama, VijayakumarVengadasalamb, Muthusamy KA. 2013 Theory on improving reading for readers with abnormal eye saccades through colored filters. Procedia - Social and Behavioral Sciences 97 ( 2013 ) 392 396 (WoS)
    2012
    • Muthusamy KA, Lian LH, Vairavan N, Chua KH, Waran V. 2012. Genetic polymorphisms of EGF 5'-UTR and NAT2 857G/A associated with glioma in a case control study of Malaysian patients.Genet Mol Res. 2012 Jun 15;11. (WoS)
    2009
    • Ned Jenkinson, Dipanker Nandi, Kalai Muthusamy, Nicola J Ray, Ralph Gregory, John F Stein, Tipu Z Aziz. 2009. Anatomy, physiology, and pathophysiology of the pedunculopontine nucleus. Mov Disord. Vol 24, No 3, Pg 319-328 (WoS/SCOPUS)
    2008
    • Muthusamy KA, Azmi K, Narayanan P, Rajagopalan R, Raman NA & Waran V.2008.Bilateral Temporal Bone Xanthoma-case report. Journal of Clinical Neuroscience 108(2):361-4 (WoS)
    • E A Pereira, K A Muthusamy, N De Pennington, C A Joint, T Z Aziz. 2008. Deep brain stimulation of the pedunculopontine nucleus in Parkinson's disease. Preliminary experience at Oxford. Br J Neurosurg. 22 Suppl 1 :S41-4 (WoS/SCOPUS)
    2007
    • Kalai Arasu Muthusamy, Vicknes Waran, Savithri D Puthucheary. 2007. Spectra of central nervous system melioidosis. J Clin Neurosci. (WoS/SCOPUS)
    • Kalai A Muthusamy, Bhooma R Aravamuthan, Morten L Kringelbach, Ned Jenkinson, Natalie L Voets, Heidi Johansen-Berg, John F Stein, Tipu Z Aziz. 2007.Connectivity of the human pedunculopontine nucleus region and diffusion tensor imaging in surgical targeting. J Neurosurg. 107 (4):814-20 (WoS/SCOPUS)
    • B R Aravamuthan, K A Muthusamy, J F Stein, T Z Aziz, H Johansen-Berg. 2007. Topography of cortical and subcortical connections of the human pedunculopontine and subthalamic nuclei. Neuroimage. (WoS/SCOPUS)
    2005
    • K Arasu, A Khairul, V Waran.2005. Neurocysticercosis an uncommon intra-cerebral infection in Malaysia. Med J Malaysia 60(4):514-6 (WoS/SCOPUS)
    2003
    • Kalai Arasu M, Dharmendra G, Ramli MN , Puthucheary SD, Waran V. 2003.Central Nervous System Meliodosis: Three cases from University Malaya Medical Center.The Philippine Journal of Neurology 7 (2): 81. (Non-WoS/Non-SCOPUS)
    Article in Proceedings
    2006
    • BR Aravamuthan, Kalai A Muthusamy, H. Johansen-Berg, N.Votes, X Liu,J Stein, T Aziz Human pedunculopontine nucleus connections traced using probabilistic diffusion tractography. 36th annual meeting, Neuroscience 2006. Oct. 14-18 in Atlanta.
    2005
    • Kalai Arasu M, Nanra J, Waran V . Use of Frame base Stereotaxy (STX) with StereoPlan assistance in the biopsy of deep seated lesions at the University Malaya Medical Centre (UMMC): Review of Cases and Complications. Annual General Meeting & Annual Scientific Meeting of the College of Surgeons, Academy of Medicine of Malaysia 2005, Penang, Malaysia ; June 2005.
    2004
    • Kalai Arasu M, Waran V . Use of Frame base Stereotaxy (STX) with StereoPlan assistance in the biopsy of deep seated lesions at the University Malaya Medical Centre (UMMC): Review of Cases and Complications. 11th ASEAN Congress of Neurological Surgeons and 6th ASEAN Neurosurgical Nursing Congress and Joint Educational Neurosurgical Meeting of ACNS , AASNS and WFNS , Bali ; Dec. 2004
    • Kalai Arasu M, Sukumar, Abdullah BJJ, Waran V CT-Guided Hook-Wire Localisation for Single Level Laminectony. 12th ASEAN Association of Radiology Congress, Penang, Malaysia; Sept. 2004
    2002
    • Kalai Arasu M, Sukumar,Waran V Review of Indication and Outcome of Decompresive Craniectomy in Severely Head Injured patients in our centre: ASEAN Young Neurosurgeon Award; 10th ASEAN Congress of Neurological Surgery, Singapore; Dec.2002
    • Kalai Arasu M, Sukumar, BJJ Abdullah, Waran V. Pre-operative Hook-wire Localisation of Thoracic Spinal Level for Intraspinal Pathology requiring a single level Laminectomy ; 10th ASEAN Congress of Neurological Surgery, Singapore; Dec.2002
    Review
    2012
    • 2012 Consensus Guidelines for the Treatment of Parkinson s Disease.
    RESEARCH PROJECT
    (Project title),(Role),(Duration),(Level)
    CG
  • EXTRACTION OF NEURAL MARKERS FOR LEARNING DISORDER USING SIGNAL ANALYSIS , Principal Investigator(PI), 2013 - 2015 (National)
    • Postgraduate Research Grant(PPP)
  • Early Screening for Dyslexia Using Electroencephalogram (EEG) Analysis , Principal Investigator(PI), 2013 - 2016 (National)
    • High Impact Research (HIR)
  • Neurosurgery Movement Disorder & Operative Device Development Research , Consultant, 2012 - 2015
    • Geran Penyelidikan Universiti Malaya (UMRG)
  • P53 and EGFR genetic polymorphism in promary brain glioma , Technical Advisor, 2008 - 2010 (National)
    • UK MRC & The Charles Wolfson Charitable Trust.
  • The Pedunculopontine Nucleus and its Connections in the Primate Central Nervous System: A Diffusion Tensor Imaging and Neural-Tracer Anatomical Study, -Researcher, 2006 - 2009 (International)
    • The Norman Collisson & Templeton fund, UK
  • Connectivity of the human pedunculopontine nucleus region and diffusion tensor imaging in surgical targeting , Researcher, 2005 - 2006 (International)
    • Wellcome Trust, UK
  • Topography of cortical and subcortical connections of the human pedunculopontine and subthalamic nuclei , -Researcher, 2005 - 2007 (International)
    • Postgraduate Research Grant (PPP) - Research
  • Early Screening for Dyslexia Using Electroencephalogram (EEG) Analysis, Principal Investigator(PI), 06/09/2013 to 05/09/2016, Tabung Pasca IPPP (Government)
    • Program Rakan Penyelidikan UM
  • EXTRACTION OF NEURAL MARKERS FOR LEARNING DISORDER USING SIGNAL ANALYSIS , Principal Investigator(PI), 19/07/2013 to 18/01/2015, Research University (Government)
    • SUPERVISION
    Postgraduate Student
    (Title of Thesis),(Name of Candidates),(Institution),(Academic Level)
    Completed
    • Identification of Saccadic Suppression in Neural Pathways during Reading in Dyslexics using Neuroimaging Methods, PARAMESWARI A/P SHUNMUGAM, University of Malaya (UM) (Post Graduate Student)
    • DIFFUSION TENSOR IMAGING AND TRACTOGRAPHY OF THE PEDUNCULOPONTINE NUCLEUS AMONG PARKINSON PATIENTS AND HEALTHY CONTROLS, ISOBEL TIMOTHEA FRENCH, University of Malaya (UM) (Post Graduate Student)
    • Identification of Saccadic Suppression in Neural Pathways during Reading in Dyslexics using Neuroimaging Methods, PARAMESWARI A/P SHUNMUGAM, University of Malaya (PhD)
    • -, MUHAMMAD FAIRUZ SHAH BIN ABD KARIM, University of Malaya (MASTER)
    • DIFFUSION TENSOR IMAGING AND TRACTOGRAPHY OF THE PEDUNCULOPONTINE NUCLEUS AMONG PARKINSON PATIENTS AND HEALTHY CONTROLS, ISOBEL TIMOTHEA FRENCH, University of Malaya (MASTER)
    UG Student/Clinical Fellowship
    (Title of Thesis),(Academic Session)
    Completed
    • Review of Cranioplasty and complication rate in UMMC from 2001-2004, 2004/2005
    • Magnetic Resonance Diffuse Tensor Imaging in Gamma Knife Surgery, 2004/2005
    • Attempted Suicide: A case Report, 2004/2005
    • Pain /Suppervisior for SSC, Dundee University, Medical student, 2008/2009
    COURSE ATTENDED
    (Course Title),(Venue),(Duration),(Level)
    External Course
  • DBS - IDIOPATHIC PARKINSON DISEASE DISEASE WORKSHOP (HYBRID), Husm, Kubang Kerian, Kelantan, 29/03/2022 to 31/03/2022 (National)
    • ACADEMIC/PROFESSIONAL SERVICES
    Academic/Professional Services
    (Contribution),(Duration),(Level),(Role)
  • Mini-review: Calcium and Parkinson s disease, 18/02/2022 to 28/02/2022, International, (Reviewer)
  • Pmengerusi Jawatankuasa Pengisian Spesifikasi ICP catheter, 01/12/2021 to 31/12/2021, University, (Internal Evaluator)
  • Peperiksaan Ikhtisas 1&2 (Neurosurgery) Krusus Sarjanh Perunatan PPSP Sesi Oct/Nov 2021, 23/11/2021 to 25/11/2021, National, (External Examiner)
  • Peperiksaan KliniKal Bagi Sarjanah Neurosurgery November 2021, 15/11/2021 to 16/11/2021, University, (Internal Examiner)
  • Alteration of white matter abnormaliies in Parkinson's dosease: a machine learningapproch, 01/10/2021 to 31/10/2021, International, (Reviewer)
  • corticla thickness changes in mild cognitive impairment in parkinson's disease, 01/05/2021 to 31/05/2021, International, (Reviewer)
  • Correlation of Neuromelanin contrast and free water in the Substantia Nigra in Parkinson's Disease, 01/04/2020 to 30/04/2020, International, (Reviewer)
  • Proctorship service for Medtronic in Deep Brain Stimulation surgery in Malasia and Southeast Asia, 01/01/2018 to 31/12/2021, International, (Mentor)
    • Evaluation Activity
    (Activity),(Duration),(Category)
  • The Pedunculopontine Nucleus and its Connections in the Primate Central Nervous System: A Diffusion Tensor Imaging and Neural-Tracer Anatomical Study, 2005 to 2009 (Thesis)
  • Persistent Prolonged Jaundice in Infancy: A Diagnostic Dilemma and the Need for Laparotomy , 1999 to 2002 (Thesis)
    • Expert Linkages
    (Linkages Description),(Organisation),(Duration of Involvement),(Level)
  • Scientific Research Program, Oxford Movement Disorder Group, 2005 (International)
    • AWARD AND STEWARDSHIP
    (Name of Award/Stewardship),(Awarding Institution),(Year Awarded),(Type of Award)
    • First place in the Asia Pacific region ATLS resident paper competation, Soviet of Trauma & Acute Care, 2021 (BEST POSTER AWARD)
    • CERTIFICATE OF EXCELLENT SERVICE, University of Malaya, 2019 (CERTIFICATE)
    • CERTIFICATE OF EXCELLENT SERVICE, University of Malaya, 2005 (CERTIFICATE)
    • Excellence in Service award, University of Malaya, 2005 (SPECIAL)
    • Gold Medal in The International Exhibition of Inventions, New Techniques and Products in Geneva, Switzerland, The International Exhibition of Inventions, New Techniques and Products in Geneva, 2005 (OTHERS)
    • Best Free Paper Award, The 11th ASEAN Congress of Neurological Surgeons and 6th ASEAN Neurosurgical Nursing Congress and Joint Educational Neurosurgical Meeting of ACNS, AASNS and WFNS, ASEAN Congress of Neurological Surgeons, 2004 (SPECIAL)
    • Bronze medal.The Experimental and Innovation Expo 2004, University of Malaya, 2004 (OTHERS)
    CONSULTANCY PROJECT
    (Project title),(Organisation),(Duration),(Role),(Level)
    • Proctorship service for Deep Brain Stimulation Surgery in Malaysia and Southeast Asia, Medtronic Malaysia, 01/01/2018 to 31/12/2021, Professional Consultant (Ir., Ar., Sr., Ts., dsbnya) (International)
    • Medtronic APAC Cranial IPG testing, Medtronic, 23/05/2017 to 31/12/2021, Consultant (International)
    PAPER PRESENTED
    (Title),(Event),(Date Presented),(Organiser),(Level)
    INVITED SPEAKER
  • PITFALLS AND AVOIDANCE IN DBS, DBS - IDIOPATHIC PARKINSON DISEASE WORKSHOP., 29/03/2022 to 31/03/2022, JABATAN NEUROSCIENCE,SCHOOL OF MEDICAL SCIENCE, HUSM, KUBANG KERIAN,KELANTAN (National)
    • ORAL PRESENTER
  • Human pedunculopontine nucleus connections traced using probabilistic diffusion tractography, 36th annual meeting, Neuroscience 2006, 14/10/2006 to 18/10/2006
    • POSTER PRESENTER
  • The Role of The Pedunculopontine Nucleus In Movement Disorder, DPAG departmental poster presentation., 25/09/2006 to 26/09/2009 (University)
  • Central Nervous System Meliodosis: Three cases from University Malaya Medical Center, 5th Biennial ASNA convention & 25th PNA Annual Convention, 13/12/2003 (International)
    • PRESENTER
  • The Pedunculopontine nucleus (PPN) and its projection system in the primate central nervous system: a tractographic and neural-tracer anatomical study, Linacre Talk, Oxford., 14/07/2008 to 15/07/2008