Curriculum Vitae

DR. MUHAMAD AQMAL BIN OTHMAN

Senior Lecturer
  • Department of Chemistry
    Faculty of Science
  • aqmal
  • 0379677022

AREAS OF EXPERTISE

  • BIO-ORGANIC CHEMISTRY
    Medicinal Chemistry, Ecopharmacognosy, Chemical Biology

ACADEMIC QUALIFICATION

  • PhD (Life Science) (2019), (Life Sciences)
    Hokkaido University, Japan
  • MSc (2016), (Natural Products Chemistry)
    Universiti Malaya (UM)
  • BSc (Hons) (Chemistry) (2014), (Chemistry)
    Universiti Malaya (UM)

MEMBERSHIPS

  • CENTRE FOR NATURAL PRODUCTS RESEARCH AND DRUG DISCOVERY (CENAR), MEMBER
    Since 2021 (University)
  • BOARD MEMBER OF INTERNATIONAL FRANCE MALAYSIA NATURAL PRODUCT LABORATORY , MEMBER
    Since 2021 (International)
  • PERDANA FELLOWS ALUMNI ASSOCIATION, MEMBER
    Since 2020 (National)
  • MALAYSIAN JAPAN RESEARCH CENTRE, MEMBER
    2021 to 2022 (International)

AWARD AND STEWARDSHIP

  • EXCELLENCE SERVICE AWARD
    University of Malaya, 2024 (University)
  • Young Scientists? Fellowship Programme
    National University of Sciences and Technology (NUST), 2023 (International)
  • Cover Journal for ACS Medicinal Chemistry Letters, Volume 10 Issue 8
    American Chemical Society, 2019 (International)
  • International Graduate Program, Training Program for Global Innovators in Life Science, Graduate School of Life Science, Hokkaido University
    Hokkaido University, 2019 (International)
  • ONO Pharmaceutical Travel Awards for Japanese Young Investigator
    Eicosanoid Research Foundation, 2019 (International)
  • Japanese Government Scholarship
    Graduate School of Life Science, Hokkaido University, 2016 (International)

PUBLICATIONS

Article in Journal
WoS
  1. Abd Rahman, Siti Nor Aisyah; Derbre, Severine; Rahman, Syarifah Nur Syed Abdul; Yap, Lee Fah; Lim, Chi-Wah Bryan; Tan, Siow-Ping; Awang, Khalijah; Zahari, Azeana; Liew, Sook Yee; Othman, Muhamad Aqmal (2024). 13C NMR-based dereplication analysis of cytotoxic styryl lactones from Goniothalamus giganteus against OSCC, JOURNAL OF MOLECULAR STRUCTURE. 1308. doi:10.1016/j.molstruc.2024.138245
  2. Salleh, Haslinda Mohd; Ablat, Abdulwali; Chong, Soon-Lim; Hazni, Hazrina; Tohar, Norsita; Fauzi, Nurulwahidah; Wahab, Habibah A.; Othman, Muhamad Aqmal; Liew, Sook Yee; Awang, Khalijah (2024). The protective effects of Zingiber zerumbet rhizome against fevers in rats, SCIENCE OF NATURE. 111(2). doi:10.1007/s00114-024-01907-7
  3. Sukumaran, S. Yaallini; Herrscher, Charline; Rasol, Nurulfazlina Edayah; Othman, Muhamad Aqmal; Liew, Sook Yee; Ismail, Nor Hadiani; Seron, Karin; Litaudon, Marc; Awang, Khalijah; El Kalamouni, Chaker; Apel, Cecile; Zahari, Azeana (2024). Targeted Isolation of Antiviral Labdane Diterpenes from the Bark of Neo-uvaria foetida (Annonaceae) using LC-MS/MS-Based Molecular Networking, JOURNAL OF NATURAL PRODUCTS. . doi:10.1021/acs.jnatprod.4c00342
  4. Ahmed, Usman; Sivasothy, Yasodha; Khan, Khalid Mohammed; Khan, Naveed Ahmed; Wahab, Siti Mariam Abdul; Awang, Khalijah; Othman, Muhamad Aqmal; Anwar, Ayaz (2023). Malabaricones from the fruit of Myristica cinnamomea King as potential agents against Acanthamoeba castellanii, ACTA TROPICA. 248. doi:10.1016/j.actatropica.2023.107033
  5. Othman, Muhamad Aqmal; Sivasothy, Yasodha (2023). Acylphenols and Dimeric Acylphenols from the Genus Myristica: A Review of Their Phytochemistry and Pharmacology, PLANTS-BASEL. 12(8). doi:10.3390/plants12081589
  6. Sivasothy, Yasodha; Leong, Kok Hoong; Loo, Kong Yong; Wahab, Siti Mariam Adbul; Othman, Muhamad Aqmal; Awang, Khalijah (2022). Giganteone A and malabaricone C as potential pharmacotherapy for diabetes mellitus, NATURAL PRODUCT RESEARCH. . doi:10.1080/14786419.2021.1885405
  7. Sivasothy, Y., Liew, S. Y., Othman, M. A., Wahab, S. M. A., Hariono, M., Nawi, M. S. M., . . . Awang, K. (2021). Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King. Tropical Biomedicine, 38(2), 79-84. doi: 10.47665/tb.38.2.044
  8. Othman, M. A., Yuyama, K., Murai, Y., Igarashi, Y., Mikami, D., Sivasothy, Y., . . . Monde, K. (2019). Malabaricone C as Natural Sphingomyelin Synthase Inhibitor against Diet-Induced Obesity and Its Lipid Metabolism in Mice. Acs Medicinal Chemistry Letters, 10(8), 1154-1158. doi:10.1021/acsmedchemlett.9b00171
  9. Othman, M. A., Sivasothy, Y., Looi, C. Y., Ablat, A., Mohamad, J., Litaudon, M., Awang, K. (2016). Acylphenols and dimeric acylphenols from Myristica maxima Warb, Fitoterapia. 111(12-17), Article
  10. Sivasothy, Y., Krishnan, T., Chan, K. G., Wahab, S. M. A., Othman, M. A., Litaudon, M., Awang, K. (2016). Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors, Molecules. 21(37), Article
Scopus
  1. Abd Rahman S.N.A., Derbre S., Syed Abdul Rahman S.N., Yap L.F., Lim C.-W.B., Tan S.-P., Awang K., Zahari A., Liew S.Y., Othman M.A. (2024). 13C NMR-based dereplication analysis of cytotoxic styryl lactones from Goniothalamus giganteus against OSCC, Journal of Molecular Structure. 1308. doi:10.1016/j.molstruc.2024.138245
  2. Mohd Salleh H., Ablat A., Chong S.-L., Hazni H., Tohar N., Fauzi N., Wahab H.A., Othman M.A., Liew S.Y., Awang K. (2024). The protective effects of Zingiber zerumbet rhizome against fevers in rats, Science of Nature. 111(2). doi:10.1007/s00114-024-01907-7
  3. Ahmed U., Sivasothy Y., Khan K.M., Khan N.A., Wahab S.M.A., Awang K., Othman M.A., Anwar A. (2023). Malabaricones from the fruit of Myristica cinnamomea King as potential agents against Acanthamoeba castellanii, Acta Tropica. 248. doi:10.1016/j.actatropica.2023.107033
Others
  1. Sivasothy, Y., Leong, K. H., Loo, K. Y., Wahab, S. M. A., Othman, M. A., & Awang, K. (2021). Giganteone A and malabaricone C as potential pharmacotherapy for diabetes mellitus. 16, 1-6.
  2. Othman, M. A., Yuyama, K., Murai, Y., Igarashi, Y., Mikami, D., Sivasothy, Y., Awang, K., & Monde, K. (2019). Malabaricone C as natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism in mice. ACS Medicinal Chemistry Letters, 10, 1154-1158.
Other Publications
  1. OHSEA: " one health in practice in Southeast Asia ": Site web ird. OHSEA: " One Health in Practice in Southeast Asia " | Site Web IRD. (n.d.). https://en.ird.fr/ohsea-one-health-practice-southeast-asia - Technical Report
  2. The symposium “one health in practice in Southeast Asia, what’s next?” was held at the Hanoi University of Science and Technology. Site Web IRD. (n.d.). https://en.ird.fr/symposium-one-health-practice-southeast-asia-whats-next-was-held-hanoi-university-science-and - Mass Media(Newspaper,Radio,Tv,Popular Magazine)
  3. Awang, K., Zahari, A., Liew, S. Y., Othman, M. A., & Hazni, H. (2022). Annual Report Malaysia France Scientific Collaboration 2021/2022. The Embassy of France in Malaysia. - Standard
  4. Othman, A. (2022, November 29). PROJECT IN ACTION: PHYTODECON. One Health SEA Project. https://ohsea.ird.fr/en/2022/11/29/project-in-action-phytodecon/ - Mass Media(Newspaper,Radio,Tv,Popular Magazine)

RESEARCH PROJECT

National
  1. 2024 - 2027, Fundamental Research Grant Scheme (FRGS)
    Unlocking Acylphenols From Myristica Species As Sphingomyelin Synthase Inhibitors And Their Lipid Regulatory Effects Towards Anti-obesity ( Principal Investigator(PI))
  2. 2021 - 2025, Fundamental Research Grant Scheme (FRGS)
    Isolation Of Covid-19 Antiviral Agents From Neo-uvaria Foetida And Miliusa Longipes Using Fast Lcms/ms Based Molecular Networking ( Co-Researcher)
  3. 2020 - 2024, Fundamental Research Grant Scheme (FRGS)
    Isolation Of Amyloid-beta (a?) Inhibitors From Malaysian Xylopia Malayana And Alstonia Angustifolia Using Fast And Effective Lc-ms/ms Based Molecular Network ( Co-Researcher)
  4. 2020 - 2023, Partnership Grant
    Enhancing the Value of Malaysian Plant Biodiversity ( Co-Researcher)
  5. 2021 - 2023, RU Geran
    Interdisciplinary And Target-based Development Of Nutraceuticals And Drugs For Prevention And Treatments Of Diseases ( Co-Researcher)
  6. 2021 - 2023, RU Geran
    Natural Hiv And Hepatitis C Inhibitors From Malaysian Flora ( Co-Researcher)
  7. 2022 - 2023, UM Community Campus-Manage by UMCARES
    OleoRangers -UM LIVING LAB ? A project for awareness creation knowledge enhancement and optimum utilisation of cooking oils ( Co-Researcher)
  8. 2023 - 2023, Partnership Grant
    Preserving Malaysian Annonaceae: A Search for SARS-CoV-2 and Dengue Antiviral Solutions ( Principal Investigator(PI))
  9. 2019 - 2022, Others MOHE - Top 100 (IIRG)-FNW
    Chemical Profiling Of Brucea Javanica `green? Formulation ( Co-Researcher)
  10. 2022 - 2025, NONE
    DISCOVERY RESEARCH OF SECONDARY METABOLITES FROM PLANTS USING LCMS/MS TOF AND MOLECULAR NETWORKING, Universiti Teknologi Mara (UITM) ( Co-Researcher)
Private
  1. 2023 - 2025, Private Funding - Manage by UMCARES
    Unit Of Research On Lipids (url) ( Co-Researcher)
International
  1. 2023 - 2024, International Funding
    Anti Neuroinflammatory Potential Of Alseodaphne Pendulifolia ( Co-Researcher)
  2. 2022 - 2023, International Funding
    A Conservation Effort On Malaysian Annonaceae Plants And Its Identification On Novel Sarscov-2 And Dengue Antiviral Agents ( Principal Investigator(PI))
  3. 2022 - 2023, International Funding
    The Development Of A New Plant Sample Repository At Universiti Malaya ( Co-Researcher)
  4. 2020 - 2022, International Funding
    Potentials Of Drug And Phytopharmaceutical Candidates Of Malaysian Plant As A Cure And Health Supplements For The Treatment Of Covid-19 Infections ( Co-Researcher)

PAPER PRESENTED

INVITED SPEAKER
  1. 13C-NMR DEREPLICATION ANALYSIS OF STYRYL LACTONES FROM Goniothalamus giganteus, Asian Chemical Biology Initiative 2023 Kuala Lumpur, Asian Chemical Biology Initiative, Supported by JSPS Core-to-Core Program (International) (15 Dec 2023 - 17 Dec 2023)
  2. A Success Story: The International France Malaysia Natural Products Laboratory (IFM NATRPOLAB), Malaysia France Convention on Higher Education, Research and Innovation, The Embassy of France, with the support of MoHE (International) (18 Oct 2023 - 20 Oct 2023)
ORAL PRESENTER
  1. UNVEILING MEDICINAL POTENTIAL OF MYRISTICA GENUS: NOVEL ANTI-AMOEBIC, ANTI-SARS-COV-2, AND ANTI-CORROSIVE AGENTS, ASIAN SYMPOSIUM ON MEDICINAL PLANTS, SPICES, AND OTHER NATURAL PRODUCTS XVII., INSTITUT TEKNOLOGI BANDUNG, JAKARTA (International) (05 Oct 2023 - 07 Oct 2023)
  2. Natural occurring sphingomyelin synthase inhibitor prevents oleic acid uptake in vitro while improving obesity in vivo, 61st Japan Lipid Biochemical Society Conference, Japan Lipid Biochemical Society and Hokkaido University (International) (04 Jul 2019 - 05 Jul 2019)
  3. Phytochemical studies of the bark of Myristica maxima Warb., The 3rd International Postgraduate Conference on Science and Mathematics, UPSI (International) (10 Oct 2015 - 11 Oct 2015)
POSTER PRESENTER
  1. 13C-NMR-BASED DEREPLICATION ANALYSIS OF STYRYL LACTONES FROM GONIOTHALAMUS GIGANTEUS, INTERNATIONAL CONFERENCE ON NATURAL PRODUCTS ICNP 2023, Malaysian Natural Products Society (MNPS) and Universiti Teknologi MARA (UiTM) (International) (11 Sep 2023 - 13 Sep 2023)
  2. Natural sphingomyelin synthase inhibitor against diet-induced obesity and its lipid metabolism, 16th International Conference of Bioactive Lipids in Cancer, Inflammation and Related Diseases, Wayne State University, Department of Pathology (International) (20 Oct 2019 - 23 Oct 2019)
  3. Oral Administration of Natural Sphingomyelin Synthase Inhibitoragainst High Fat Diet-Induced Obesity and its Lipid Metabolism in Mice, 61st Symposium on The Chemistry of Natural Products, Department of Mathematical Molecular Life Sciences, Graduate School of Science, Hiroshima University and Kinki Nippon Tourist Kansai Kansai MICE Branch (International) (11 Sep 2019 - 13 Sep 2019)
  4. Discovery of natural sphingomyelin synthase inhibitor and its orally efficacious improving obesity in vivo, 6th International Life-Science Symposium, Faculty of Life Science, Hokkaido University (International) (19 Nov 2018 - 19 Nov 2018)
  5. Isolation and synthesis of first natural SMS inhibitors: towards therapeutic application of metabolic syndrome and Alzheimer s disease, 59th Symposium on The Chemistry of Natural Products, Hokkaido University (International) (20 Sep 2017 - 22 Sep 2017)
  6. Phytochemical Studies of the bark of Myristica maxima Warb., Annual Colloquium on Drug Development from Natural Products, Centre of Natural Product Research and Drug Discovery (CENAR) University of Malaya (University) (12 Aug 2015 - 12 Aug 2015)

ACADEMIC/PROF. SERVICES

Evaluation
  1. (2024) Frgs Grant Proposal Evaluator 2024, University, (Internal Evaluator)
  2. (2023) Evaluator - Phd Proposal Defense Nor Akmalayati, University, (Internal Evaluator)
  3. (2023) Evaluator - Phd Proposal Defense Noura Alshaq, University, (Internal Evaluator)
  4. (2023) Evaluator - Msc Candidature Defense S. Yaallini, University, (Internal Evaluator)
  5. (2023) Evaluator - Msc Proposal Defense Nik Nor Soleha, University, (Internal Evaluator)
  6. (2023) Evaluator - Msc Proposal Defense Aina Najiha, University, (Internal Evaluator)
  7. (2022) Jawatankuasa Penyaringan Kertas Soalan Sesi 2021/2022, University, (Reviewer)
  8. (2022) Ahli Pengapit Chra, University, (Reviewer)
  9. (2021) Panel of Candidature Defense (Phd Student), University, (Internal Examiner)
  10. (2021) Panel of Candidature Defense (Phd Student), University, (Internal Examiner)
  11. (2021) Panel of Proposal Defense (Phd Student), University, (Internal Examiner)
Contribution to external organisation
  1. (2024) Collaborative Research Agreement (Moa) Between UiTM and UM, National, (Resource Person)
  2. (2023) Scientific Collaboration Agreement (Moa), International, (Resource Person)
  3. (2023) Research Agreement (Moa), International, (Resource Person)
  4. (2022) Collaborative Research Agreement (Moa), International, (Academic Appointment )
  5. (2017) Collaborative Research Program, University of Malaya and Hokkaido University, International
Contribution to event
  1. (2023) Local Coordinator, International, (Event Coordinator)
  2. (2023) Panelist for Special Session 2-4 (a Success Story The International French Malaysian Natural Products Laboratory - Ifm Natprolab), International, (Panelist/Moderator)
  3. (2023) Chairperson, University, (Panelist/Moderator)
  4. (2023) The Global Young Scientists Summit in Singapore Brings Together Bright Young Researchers and Top Scientific Minds from Around The World to Discuss Science and Technology Trends, Future Game Changers and How Research Could Address Major Global Challenges., International, (Participant)
  5. (2022) Secretary 1 and Participants, International, (Event Organiser)
Mentoring
  1. (2021) Trainer for 53rd Malaysian International Chemistry Olympiad Selection (Phase 4), National, (Mentor)

SUPERVISION

Postgraduate Student
  1. (2024) CHEMICAL CONSTITUENTS FROM MILIUSA AND CURCUMA SPECIES WITH THEIR ANTI- VIRAL ACTIVITY, LI QIAN
  2. (2024) ISOLATION AND CHARACTERIZATION OF COMPOPUNDS FROM MILIUSA LONGIPES KING, DESMOS DUMOSUS WITH AIDS OF LCMS/MS MOLECULAR NETWORKING AND ITS ANTIVIRAL PROPERTIES, MAHFUZAH BINTI YUSOFF
  3. (2024) ISOLATION OF NEUROPROTECTIVE AGENTS FROM XYLOPIA GENUS WITH THE AIDS OF LCMS/MS MOLECULAR NETWORKING, NURUL AZIRAH BINTI MOHD NAWI
  4. (2023) Secondary Metabolites from the Bark of Goniothalamus Giganteus and their Cytotoxic Activities, SITI NOR AISYAH BINTI ABD RAHMAN

TEACHING

Master
  1. (2023) SQC7006 - Molecular Spectroscopic Analysis
Bachelor
  1. (2024) SIC2025 - Chemistry and Society
  2. (2024) SIC3049 - Food Chemistry
  3. (2024) SID3014 - Food Processing and Safety
  4. (2024) SIC2019 - Practical of Organic Chemistry Ii
  5. (2024) SIC2024 - Spectroscopic Methods in Organic Chemistry
  6. (2023) SIC2025 - Chemistry and Society
  7. (2023) SIC3049 - Food Chemistry
  8. (2023) SID2005 - Food Chemistry
  9. (2023) SID3014 - Food Processing and Safety
  10. (2023) GIS1002 - Green Chemistry
  11. (2023) SIC1002 - Inorganic Chemistry I
  12. (2023) SIC2019 - Practical of Organic Chemistry Ii
  13. (2023) SIC1011 - Safety and Basic Laboratory Techniques
  14. (2022) SIC2025 - Chemistry and Society
  15. (2022) SID2005 - Food Chemistry
  16. (2022) GIS1002 - Green Chemistry
  17. (2022) SIC1012 - Laboratory Skills
  18. (2022) SIC2019 - Practical of Organic Chemistry Ii
  19. (2022) SIC1011 - Safety and Basic Laboratory Techniques
  20. (2022) SIC2007 - Spectroscopic Methods in Organic Chemistry
  21. (2021) SID2005 - Food Chemistry
  22. (2021) SIC1003 - Organic Chemistry I
  23. (2021) SIC2002 - Organic Chemistry Ii
  24. (2021) SIC1011 - Safety and Basic Laboratory Techniques
  25. (2021) SIC2007 - Spectroscopic Methods in Organic Chemistry
  26. (2021) SIC2002 - Organic Chemistry Ii (Lab)
  27. (2021) SIC2007 - Spectroscopic Methods in Organic Chemistry

SOCIAL RESPONSIBILITY ACTIVITIES

  • Instructor for The International Chemistry Olympiad (Icho) Go for Gold Program, (20 Nov 2021 - 22 Mar 2022) (International)
  • Participant in The International Conference On Tropical Sciences: Contributions to Sustainability (Tropsc 2021), (25 Oct 2021 - 27 Dec 2021) (International)
  • Trainers for 53rd Malaysian International Chemistry Olympiad Selection, (31 May 2021 - 10 Jun 2021) (International)

COURSE ATTENDED

Internal / External Course
INTERNAL COURSE- ORGANIZED BY PTJ
  1. INTRODUCTION TO FRENCH LANGUAGE AND CULTURE, Online (09 Jun 2021 - 09 Jun 2021)
  2. CERAMAH BULANAN INSTITUT SAINS MATEMATIK "SYAFAAT AL-QURAN DI MUSIM WFH" , Secara Google Meet (16 Jul 2021 - 16 Jul 2021)
  3. ACU UM EARLY CAREER RESEARCHERS DEVELOPMENT PROGRAMME, Hotel Ve Bangsar South Kuala Lumpur (03 Jun 2022 - 03 Jun 2022)
  4. SHARING SESSION: MY FRGS JOURNEY, Microsoft Teams (27 Feb 2023 - 27 Feb 2023)
EXTERNAL COURSE
  1. CHEMICAL HEALTH RISK ASSESSMENT, Aras 2, Menara Niosh, Niosh, Bandar Baru Bangi, Selangor, Malaysia (15 Nov 2021 - 26 Nov 2021)
CONFERENCE
  1. 7TH PALM INTERNATIONAL NUTRA-COSMECEUTICAL CONFERENCE (PINC) 2023, Millennium Grand Ballroom, Level 1, Le Meridien, Putrajaya (22 Aug 2023 - 22 Aug 2023)
  2. INTERNATIONAL CONFERENCE ON NATURAL PRODUCTS ICNP 2023, Aloft Kuala Lumpur Sentral, Malaysia. (11 Sep 2023 - 13 Sep 2023)
  3. ASIAN SYMPOSIUM ON MEDICINAL PLANTS, SPICES, AND OTHER NATURAL PRODUCTS XVII., Institut Teknologi Bandung, Jakarta (04 Oct 2023 - 08 Oct 2023)