PERSONAL DETAIL


DR. AJANTHA A/P SINNIAH

Department of Pharmacology
Faculty of Medicine
 
  ajantha.sinniah@um.edu.my
 Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, W.Persekutuan Kuala Lumpur, Malaysia
 
ResearcherID Link
  http://www.researcherid.com/rid/L-5684-2017

ACADEMIC QUALIFICATION
(Qualification), (Institution).



PROFESSIONAL
(Organisation), (Role), (Year), (Level).


  • British Pharmacological Society, Member, 2011 to 2019, (International)
  • Biochemical Society, Member, 2013 to 2018, (International)
  • Royal Society of Biology, Member, 2015 to 2019, (International)

ADMINISTRATIVE DUTIES
(Role), (Level), (Start date),(End Date).


  • Co-Treasurer of MSPP 2019, National, 07/01/2019 to 31/07/2019
  • Assistant Coordinator for Dentistry programe (Pharmacology), Faculty, 02/10/2018 to 01/12/2020 (PERLANTIKAN TIMBALAN KETUA TAHUN, PENYELARAS DISPLIN DAN PENYELARAS KURSUS BAGI PROGRAM IJAZAH SARJANA MUDA PEMBEDAHAN PERGIGIAN BAGI TAHUN DUA (2) 2018/2019)
  • Penasihat Akademik bagi Pelajar Peringkat 1, Kursus MBBS, Sesi Akademik 2018/2019, Faculty, 10/09/2018 to 10/09/2019 (Penasihat Akademik bagi Pelajar Peringkat 1, Kursus MBBS, Sesi Akademik 2018/2019), Faculty, 10/09/2018 to 31/12/2020 (Penasihat Akademik bagi Pelajar Peringkat 1, Kursus MBBS, Sesi Akademik 2018/2019, Faculty, 10/09/2018 to 10/09/2019 (Penasihat Akademik bagi Pelajar Peringkat 1, Kursus MBBS, Sesi Akademik 2018/2019))
  • PERLANTIKAN SEBAGAI PENOLONG KOORDINATOR BAGI KURSUS ELEKTIF FAKULTI DI JABATAN FARMAKOLOGI, Faculty, 23/05/2018 to 01/01/2020 (PERLANTIKAN SEBAGAI PENOLONG KOORDINATOR BAGI KURSUS ELEKTIF FAKULTI DI JABATAN FARMAKOLOGI)
  • Scientific committee: Stem Cell and Cancer Symposium (SCCS) 2018, International, 02/04/2018 to 18/10/2018
  • Organizing committee: Research symposium on metabolic syndrome (University Malaya-University of Edinburgh), International, 05/12/2017 to 07/12/2017 (Research symposium on metabolic syndrome)
  • Assistant Manager: Document Quality, Faculty, 23/05/2017 to 22/05/2020 (Managing the documentation for quality control and audit)

AREAS OF EXPERTISE
(Area).


  • Medical Pharmacology (Immunopharmacology)


RECENT SELECTED PUBLICATIONS
(Publication).


Article in Academic Journals

2019
  • Cheng KJ, Alshawsh MA, Mejia Mohamed EH, Thavagnanam S, Sinniah A, Ibrahim ZA (2019). HMGB1: an overview of its versatile roles in the pathogenesis of colorectal cancer. Cell Oncol (Dordr). 2019 Nov 1. doi: 10.1007/s13402-019-00477-5. (ISI-Indexed)
  • Sinniah A, Yazid S, Bena S, Oliani SM, Perretti M and Flower RJ (2019) Endogenous Annexin-A1 Negatively Regulates Mast Cell- Mediated Allergic Reactions. Front. Pharmacol. 10:1313. doi: 10.3389/fphar.2019.01313 (ISI-Indexed)
  • Koosha S, Mohamed Z, Sinniah A, Ibrahim Z, Seyedan A, Alshawsh MA. Antiproliferative and apoptotic activities of 8-prenylnaringenin against human colon cancer cells. Life Sci. 2019 Jul 3:116633. doi: 10.1016/j.lfs.2019.116633. (ISI-Indexed)
  • Koosha S, Mohamed Z, Sinniah A & Alshawsh M.A. (2019) Investigation into the Molecular Mechanisms underlying the Anti-proliferative and Anti-tumorigenesis activities of Diosmetin against HCT-116 Human Colorectal Cancer. Scientific Reports. 2019; 9:5148, https://doi.org/10.1038/s41598-019-41685-1 (ISI-Indexed)
  • Wandeep Kaur, Vimala Balakrishnan, Omer Rana, & Ajantha Sinniah (2019) Liking, sharing, commenting and reacting on Facebook: User behaviors’ impact on sentiment intensity, Telematics and Informatics, 39, 25 - 36, (ISI-Indexed)
  • Sanaz Koosha, Zahurin Mohamed, Ajantha Sinniah, and Mohammed A. Alshawsh*. Evaluation of Anti-Tumorigenic Effects of Diosmetin Against Human Colon Cancer Xenografts in Athymic Nude Mice. Molecules. 2019. (ISI-Indexed)

2017
  • Sinniah A, Yazid S and Flower RJ (2017) The Anti-allergic Cromones: Past, Present, and Future. Front. Pharmacol. 8:827. doi: 10.3389/fphar.2017.00827 (ISI-Indexed)

2016
  • Sinniah A., Yazid S., M Perretti, Solito E., and Flower R.J (2016). The role of Annexin A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80. Int Immunopharmacol. 2016 Jan 21; 32:87-95. (ISI-Indexed)

2013
  • Yazid S., Sinniah A., Solito E., Calder V Flower RJ (2013) Anti-Allergic Cromones Inhibit Histamine and Eicosanoid Release from Activated Human and Murine Mast Cells by Releasing Annexin A1. PLoS ONE 8(3): e58963. doi:10.1371/journal.pone.0058963. (ISI-Indexed)

AREAS OF RESEARCH
(Project title), (Role), (From)-(Until), (Level), (Source).


  • The Development Of Health Management App Incorporating Speech-based Interaction For The Older Adults, Consultant, 2019 - 2021, Others MOHE - Top 100 (IIRG)-HWB, (National)
  • Investigation of HMGB1 and IL-1a secretion and function in inflammatory responses of human colon epithelial (normal) and colorectal cancer cells. (06/04/2018 to 06/04/2020), Co-Investigator, 2018 - 2020, Bantuan Kecil Penyelidikan (BKP), (National)
  • Investigation Of Hmgb1 And Il-1a Secretion And Function In Inflammatory Responses Of Human Colon Epithelial (normal) And Colorectal Cancer Cells., Consultant, 2018 - 2020, Bantuan Kecil Penyelidikan (BKP), (National)
  • Anti-colorectal cancer properties of a bioactive flavone and its underlying mechanism, Principal Investigator(PI), 2017 - 2019, Bantuan Kecil Penyelidikan (BKP), (National)
  • Anti-colorectal cancer properties of a bioactive flavone and its underlying mechanism, Principal Investigator(PI), 2017 - 2019, Bantuan Kecil Penyelidikan (BKP), (National)

PRESENTATIONS
(Title), (Event), (Date Presented), (Organiser), (Level).


ORAL
  • On the mechanism of action of the anti-allergic cromones, BPS Winter Meeting, 2012-12-18 to 2012-12-20, British Pharmacological Society, (International)
  • Anti-Allergic Cromones Inhibit Histamine and Eicosanoid Release from Activated Human and Murine Mast Cells by Releasing Annexin A1, 11th World Congress in Inflammation Infection, 2013-09-21 to 2013-09-25, Brazilian Society of Immunology (SBI), (International)
  • On the role of Annexin A1 in the actions of nedocromil in human and murine mast cells, Pharmacology 2014, 2014-12-16 to 2012-12-18, British Pharmacological Society, (International)
POSTER
  • Anti-allergic drugs exert Annexin-A1 phosphorylation in U937 cells., William Harvey Day, 2012-10-18 to 2012-10-19, Queen Mary University of London, (International)
  • Annexin A1 as an endogenous regulator of mast cell degranulation., William Harvey Day, 2013-10-16 to 2013-10-17, Queen Mary University of London, (International)

EVALUATION ACTIVITIES
(Description), (Evaluation Activity),(Year).


  • Monitoring and ensuring the fairness, timeliness, thoroughness of the peer-review editorial process., Article In Journal ,  (2018)
  • Purification, characterization and anti-neoplastic activity of cytotoxic venom proteins from Malayan Blue coral snake, Thesis ,  (2018 - 2018)
  • Effect of Catha edulis (Khat) on body weight, serum metabolic biomarkers and expression of related genes in obese C57BL/6J male mice., Thesis ,  (2018 - 2018)
  • Evaluation of anti-dopaminergic activity of Mitragyna speciosa (Kratom) leaves for the treatment of alcohol dependence in animal models., Thesis ,  (2018 - 2018)
  • Evaluation of Candidature defence for PhD (Ms Pushpa Gandi Sangaran), Thesis ,  (2018 - 2018)
  • I have reviewed a manuscript for Asia Pacific Journal of Public Health., Article In Journal ,  (2017 - 2017)
  • I have reviewed a manuscript for the Journal of Health and Translational Medicine, Article In Journal ,  (2017 - 2017)

SUPERVISION


POST GRADUATE STUDENT
(Name of Degree), (Name of Candidates), (Title of Thesis), (Academic Session)

Ongoing
  • Master Degree, Cheng Kim Jun, To Elucidate the Functional Roles of HMGB1 in Colorectal Cancer., 2018/2019
  • Doctoral Degree (phd), Sanaz Koosha, Investigation into the Molecular Mechanisms Underlying the Anti-proliferative and Anti-tumorigenesis activities of Diosmetin against Human Colorectal Cancer, 2018/2019
  • Master Degree, Thanusha M Ganesan, ANNEXIN A1 REGULATES THE ANTI-CANCER EFFECTS OF PUNICALAGIN IN COLORECTAL CANCER CELL LINES, 2017/2018

TEACHING
(Course Title), (Academic Session), (No of Student), (No of Contact Hours).


FIRST DEGREE
  • PBL Block 9: Renal and Urology, 2017/2018(2), 8, 7.5
  • PBL Block 11: Oncology and Palliative Care, 2017/2018(2), 8, 6
  • DRUG ACTION AND DISCOVERY, 2017/2018(2), 50, 7
  • PHARMACOLOGY, 2017/2018(3), 60, 2
  • PHARMACOLOGY, 2017/2018(1), 50, 4
  • BLOCK 11: ONCOLOGY AND PALLIATIVE CARE, 2017/2018(2), 7, 10.5
  • BLOCK 9: RENAL AND UROLOGY, 2017/2018(2), 7, 7.5
  • UMMP, 2017/2018(1), 7, 1
  • ADVANCES IN MEDICAL PHARMACOLOGY, 2017/2018(2), 5, 4
  • PHARMACOLOGY IN NURSING, 2017/2018(2), 7, 1.5
  • UMMP, 2017/2018(2), 120, 1
  • PRINCIPLES IN PHARMACOLOGY AND TOXICOLOGY, 2017/2018(1), 42, 9