ACADEMIC QUALIFICATION
PhD, (Molecular Medicine)
Universiti Malaya (UM)
MSC, (APPLIED BIOPHARMACEUTICAL BIOTECHNOLOGY AND ENTREPRENEURSHIP)
University of Nottingham
BSC (Hons), (Biotechnology)
University of Nottingham
MEMBERSHIPS
MALAYSIAN SOCIETY FOR MOLECULAR BIOLOGY AND BIOTECHNOLOGY (MSMBB), MEMBER
2024 to 2025 (National)
MALAYSIAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, MEMBER
2024 to 2024 (National)
AWARD AND STEWARDSHIP
Best Overall Oral Presentation
2024, 14TH MALAYSIA SYMPOSIUM OF BIOMEDICAL SCIENCE 2024, (National)
2023 Iq Consortium/Aaalac International Global 3rs Award - Pacific Rim Recipient
2023, IQ Consortium/AAALAC International , (International)
YSN-ASM Young Investigator Award for Best Poster
2017, Young Scientist Network-Academy of Science Malaysia, National
PUBLICATIONS
Ayob AZ, Ramasamy TS*. Prolonged hypoxia switched on cancer stem cell-like plasticity in HepG2 tumourspheres cultured in serum-free media. In Vitro Cell Dev Biol Anim. 2021 Oct;57(9):896-911. doi: 10.1007/s11626-021-00625-y.
Ain Zubaidah Ayob & Thamil Selvee Ramasamy* (2018). Cancer stem cells as key drivers of tumour progression. Journal of Biomedical Science (2018) 25:20
Ramasamy TS, Ayob AZ, Myint HHL, Thiagarajah S, Amini F(2015). Targeting Colorectal Cancer Stem Cells Using Curcumin and Curcumin Analogues: Insights into the Mechanism of the Therapeutic Efficacy. Cancer Cell International 15:96.
Ayob, A. Z., Ramasamy, T. S. Enrichment of hepatic cancer stem-like cells in different in vitro cultures systems exhibiting distinct molecular and cellular characteristics recapitulate tumour heterogeneity. MTERMS 2016. Front. Bioeng. Biotechnol. doi: 10.3389/conf.FBIOE.2016.02.00017
RESEARCH INTEREST
Cancer Biology (Cancer stem cells, Chemoresistance, Cancer plasticity, 3D models)
Gene expression (MicroRNA, Transcriptomics, Integrative Omics)
RESEARCH PROJECT
2024 - 2027, Fundamental Research Grant Scheme (FRGS)
Identifying Hfpef (heart Failure With Preserved Ejection Fraction): The Role Of Molecular And Biochemical Signatures Of Ferroptosis ( Co-Researcher)
2024 - 2027, UNIVERSITI MALAYA RESEARCH EXCELLENCE GRANT (UMREG)
Elucidating The Neuroinflammation Modulatory Effects Of Rhizome Extracts From Three Zingiber Species In An Alzheimer?s Disease Cell Model ( Co-Researcher)
2023 - 2026, Fundamental Research Grant Scheme (FRGS)
Elucidating The Mechanistic Roles Of Spock1, A Matricellular Proteoglycan, As A Modulator Of Epithelial-mesenchymal Transition And Cancer Stem Cells Plasticity In Hepatocellular Carcinoma Cell Lines ( Principal Investigator(PI))
2023 - 2025, International Funding
Decoding The Mechanisms Of Cancer Stem Cell Plasticity For Therapeutic Development ( Co-Researcher)
PAPER PRESENTED
MOLECULAR AND CELL BIOLOGY, 9th Ophthalmology Basic Science Examination (MedEx) Preparatory Course, Department of Ophtalmology, Faculty of Medicine, Universiti Malaya (National) (03 Sep 2024 - 06 Sep 2024)
Maximising the Success of Your qPCR Experiment, MOMPES QPCR WORKSHOP, Department of Molecular Medicine (National) (27 Jul 2023 - 27 Jul 2023)
Molecular and Cell Biology, 7th Opthalmology Basic Science Examination (MedEx) Preparatory Course, Departmnent of Ophthalmology, Faculty of Medicine, UM (National) (26 Apr 2023 - 28 Apr 2023)
Unravelling the Molecular Regulatory Networks of Cancer Stem Cells Plasticity, Live Webinar Series: BREAKFAST@UMHEALTH , UM Health (University) (22 Feb 2023 - 22 Feb 2023)
Integrated microRNA and mRNA regulatory networks associated with cancer stem-like cells in hepatocellular carcinoma., 2nd PhD Research Symposium in Health Sciences and Biomedicine., Universidad Aut noma de Madrid (International) (21 May 2021 - 21 May 2021)
Ramasamy T.S. Integrated miRNA-mRNA analysis revealed distinct molecular signatures and regulatory networks in cancer stem-like cell models of hepatocellular carcinoma., Virtual Keystone Symposia. Cancer Stem Cells: Advances in Biology and Clinical Translation eSymposia, eSymposia Keystone (International) (19 May 2021 - 21 May 2021)
Effects of hypoxia on the induction of cancer stem cells-like properties in tumourspheres derived from HepG2 cells, Tissue Engineering and Regenerative Medicine Postgraduate Symposium (TERMSYMPO) , Tissue Engineering Centre (TEC), UKM and TESMA (National) (07 Nov 2017 - 07 Nov 2017)
Enrichment of hepatic cancer stem-like cells in different in vitro cultures systems exhibiting distinct molecular and cellular characteristics recapitulate tumour heterogeneity. , 6th Malaysian Tissue Engineering and Regenerative Medicine Scientific Meeting , TESMA (National) (17 Nov 2016 - 18 Nov 2016)
Association of rhythmicity between circadian clock and stemness properties in hepatocellular carcinoma., Faculty of Medicine Research Day , Faculty of Medicine (University) (31 May 2016 - 31 May 2016)
ACADEMIC/ PROF. SERVICES
(2024) Phd Proposal Defence - Deborah Joyce - The Upregulation of Microrna 146b-5p in The Metabolic Crosstalk Between Macrophages and The Cholesterol Pathway in Bladder Cancer Progression: a Mechanistic Study, University, (Internal Assessor)
(2024) Phd Confirmation Defence: Suha Azizan - Investigating The Functional Interplays Between Il-1α and Il-8 in Mediating Epithelial-to-Mesenchymal Transition (Emt) in Colorectal Cancer, University, (Internal Examiner)
(2024) The Impact of Epithelial-Mesenchymal Transition (Emt) Induced by Metabolic Processes and Intracellular Signaling Pathways On Chemo- Resistance, Metastasis, and Recurrence in Solid Tumors, International, (Reviewer)
(2024) Masters Candidature Defence - Qistina Marsya Aziz Zainal - Circadian Compositional Variation of Human Milk: Establishing Baseline Profiles Associated With The Development and Maintenance of Infant Oral Health, University, (Internal Examiner)
(2023) Master's Candidature Defense - Muhammad Aiman Akmal Bin Shahhiran - Investigating The Mechanisms Involved in Mitochondrial Dysfunction Mediated by Dihydroorotate Dehydrogenase Inhibitors in Breast Cancer Cells, University, (Internal Examiner)
(2023) Phd Proposal Defence - Dyg Mastura Adenan - Elucidating The Predictors for Early Detection of Diastolic Dysfunction in Women With Obesity, University, (Reviewer)
(2023) Phd Candidature Defence - Andy Lim Shing Seng - Preclinical Assessment of Composition Purity, Immunoreactivity and Neutralization Efficacy of Pakistani Viper Antivenom, University, (Internal Examiner)
(2025) Academic Advisor - MBBS Stage 1 & 2 Cohort 2022/2023, University, (Academic Advisor)
SUPERVISION
(2024) MIC4001-Enhancing Sensitivity of Food Screening Device for Foodborne Pathogen Detection
(2023) MIC4001 BiomedSci - A Study to Characterise Sorafenib Resistance in 2D and 3D cultures of HepG2 cells
(2024) INVESTIGATION OF THE ROLES OF SPOCK1 IN THE INTERPLAY BETWEEN EPITHELIAL-MESENCHYMAL TRANSITION AND CANCER STEM CELL PLASTICITY IN HEPATOCELLULAR CARCINOMA CELL LINES, RACHEL HOE HUEY XUAN
TEACHING
(2024) MIA - Bachelor of Medicine, Bachelor of Surgery
(2024) DIA1003 - Biochemistry
(2024) GDM0006 - Global Trends in Food and Health
(2024) GIM2001 - Your Body and Its Health
(2023) MIA - Bachelor of Medicine, Bachelor of Surgery
(2023) DIA1003 - Biochemistry
(2023) GDM0006 - Global Trends in Food and Health
(2023) MIX3001 - Techniques in Molecular Medicine
(2022) DIA1003 - Biochemistry
SOCIAL RESPONSIBILITY ACTIVITIES
Panel Penemuduga Bagi Kemasukan Ke Program MBBS 2024/2025, (10 Jun 2024 - 14 Jun 2024) (University)
Panel Penemuduga Bagi Kemasukan Ke MBBS 2023/2024, (13 Jul 2021 - 15 Jul 2021), (07 Jun 2023 - 21 Jun 2023) (University)
Science Outreach : Lab of Wonders Workshop, (24 May 2023 - 31 May 2023) (National)
