Curriculum Vitae

DR. ADYANI AZIZAH BINTI ABD HALIM

Senior Lecturer
  • Department of Oral and Craniofacial Sciences
    Faculty of Dentistry
  • adyaniazizah
  • 0379677405

AREAS OF EXPERTISE

  • PROTEINS
    Protein Folding & Denaturation, Enzyme Stability, Serum Albumin, Ligand-Protein Interaction

ACADEMIC QUALIFICATION

  • PHD(UM), (Science)
    Universiti Malaya (UM)
  • MS(UM), (Science)
    Universiti Malaya (UM)
  • BSC(SAINS)(UM), (Science)
    Universiti Malaya (UM)

ADMINISTRATIVE DUTIES

  • Head of Department
    01 Apr 2023 - present (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • Committee Members
    19 Jan 2022 - 18 Jan 2025 (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • Acting Head of Department
    15 Aug 2022 - 31 Dec 2022 (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • Committee Members
    09 May 2022 - 16 Oct 2022 (National)
  • Coordinator
    14 Dec 2021 - 18 Sep 2022 (Faculty)
  • Coordinator
    30 May 2022 - 18 Jun 2022 (Faculty)
  • Committee Members
    30 Nov 2021 - 23 Mar 2022 (Faculty)
  • Ketua Aktiviti Bulan Ramadhan peringkat jabatan
    09 Apr 2019 - 31 Dec 2021 (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • Ahli jawatankuasa modul bersepadu (Dental Anomalies) program ijazah sarjana muda pembedahan pergigian sesi akademik 2019/2020
    22 Jul 2019 - 22 Jul 2020 (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • Ahli UMDEED
    02 May 2019 - 31 May 2020 (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • TIMBALAN PENYELARAS PROBLEM BASED LEARNING (PBL) BAGI PROGRAM IJAZAH SARJANA MUDA PEMBEDAHAN PERGIGIAN
    07 Aug 2018 - 19 Jul 2019 (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • Penasihat Majlis Makan Malam Tahunan Persatuan Pelajar Islam Pergigian Universiti Malaya 2019
    01 Mar 2019 - 26 Apr 2019 (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • Ahli Jawatankuasa kecil Hadiah Persidangan Sainstifik Mahasiswa Pergigian Universiti Malaya
    26 Feb 2019 - 06 Mar 2019 (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • PENASIHAT PROJEK MALALM TAUTAN HATI PERSATUAN PELAJAR ISLAM PERGIGIAN UNIVERSITI MALAYA (PPIPUM) SESI 2018/2019
    15 Nov 2018 - 15 Nov 2018 (Faculty)
  • Food & beverage committee for 19th Student Scientific Conference 2018
    27 Sep 2017 - 08 Mar 2018 (Department of Oral and Craniofacial Sciences, Faculty of Dentistry)
  • Penasihat Projek Rehlah Penyatu Persatuan Pelajar Islam Pergigian Universiti Malaya (PPIPUM) 2017/2018
    07 Dec 2017 - 16 Dec 2017 (University Malaya)

MEMBERSHIPS

  • FULL MEMBER OF ROYAL SOCIETY OF BIOLOGY, MEMBER
    2023 to 2024 (International)
  • MEMBER OF MALAYSIAN SOCIETY OF ORAL MICROBIOLOGISTS AND ORAL IMMUNOLOGISTS, MEMBER
    Since 2018 (National)
  • FULL MEMBER, MEMBER
    2021 to 2022 (International)

PUBLICATIONS

Article in Journal
WoS
  1. Hidayat, Ahmad Fadhlurrahman Ahmad; Mohamad, Saharuddin B.; Tayyab, Saad; Harun, Wan Himratul Aznita Wan; Abd Halim, Adyani Azizah (2025). Molecular interaction of a protease inhibitor, leupeptin, with human serum albumin: Insights from calorimetry, spectroscopy, microscopy, and computational approaches, JOURNAL OF MOLECULAR STRUCTURE. 1321. doi:10.1016/j.molstruc.2024.139670
  2. Abubakar, Mujaheed; Mohamad, Saharuddin B.; Abd Halim, Adyani Azizah; Tayyab, Saad (2024). Unveiling the molecular interaction of hepatitis B virus inhibitor, entecavir with human serum albumin through computational, microscopic and spectroscopic approaches, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS. . doi:10.1080/07391102.2024.2311331
  3. Asngari, Nurul Jannah Mohd; Bakar, Khairul Azreena; Feroz, Shevin Rizal; Razak, Fathilah Abdul; Abd Halim, Adyani Azizah (2024). Interaction mechanism of a cysteine protease inhibitor, odanacatib, with human serum albumin: In vitro and bioinformatics studies, BIOPHYSICAL CHEMISTRY. 305. doi:10.1016/j.bpc.2023.107140
  4. Abubakar, Mujaheed; Mohamed, Saharuddin B.; Halim, Adyani Azizah Abd; Tayyab, Saad (2023). Use of computational and wet lab techniques to examine the molecular association between a potent hepatitis C virus inhibitor, PSI-6206 and human serum albumin, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY. 294. doi:10.1016/j.saa.2023.122543
  5. Hasnan, M. M. I. Megat; Lim, G. P.; Nayan, N.; Soon, C. F.; Abd Halim, A. A.; Ahmad, M. K.; Said, S. M.; Ali, M. S. Mohamed; Noor, I. M. (2023). The investigation of chlorpyrifos (Cpy) detection of PEDOT:PSS-MXene(Ti2CTX)-BSA-GO composite using P-ISFET reduction method, POLYMER BULLETIN. . doi:10.1007/s00289-022-04105-5
  6. Tayyab, Saad; Tio, Jaclyn Wei Qi; Abd Halim, Adyani Azizah (2023). THE FLUORESCENCE SIGNAL OF ALBUMIN-BOUND BILIRUBIN TO MONITOR DRUG-INDUCED BILIRUBIN DISPLACEMENT FROM HUMAN SERUM ALBUMIN, REVUE ROUMAINE DE CHIMIE. 68(9), 429-434. doi:10.33224/rrch.2023.68.9.03
  7. Abubakar, Mujaheed; Kandandapani, Salanee; Mohamed, Saharuddin B.; Abd Halim, Adyani Azizah; Tayyab, Saad (2022). Shedding light on the molecular interaction between the Hepatitis B virus inhibitor, clevudine, and human serum albumin: Thermodynamic, spectroscopic, microscopic, and in silico analyses, JOURNAL OF MOLECULAR LIQUIDS. 368. doi:10.1016/j.molliq.2022.120737
  8. Tayyab, S.; Mat, T. N. N. Tuan; Abd Halim, A. A. (2022). DIFFERENTIAL STABILIZING EFFECTS OF BUFFERS ON STRUCTURAL STABILITY OF BOVINE SERUM ALBUMIN AGAINST UREA DENATURATION, LATIN AMERICAN APPLIED RESEARCH. 52(1), 7-13. doi:10.52292/j.laar.2022.738
  9. Tan, C. Y., Lim, C. S., Liew, S. M., Abd Halim, A. A., & Tayyab, S. (2021). Lysine modification of human serum albumin and its effect on protein conformation and nalidixic acid binding. Journal of the Indian Chemical Society, 98(3). doi: 10.1016/j.jics.2021.100031
Scopus
  1. Halim A.A.A., Ridzwan F.W., Mohamad S.B., Tayyab S. (2022). Targeting the nalidixic acid binding site on human serum albumin through computational approach: A re-investigation, Biointerface Research in Applied Chemistry. 12(2), 1520-1525. doi:10.33263/BRIAC122.15201525
  2. Tayyab S., Mat T.N.N.T., Halim A.A.A. (2022). DIFFERENTIAL STABILIZING EFFECTS OF BUFFERS ON STRUCTURAL STABILITY OF BOVINE SERUM ALBUMIN AGAINST UREA DENATURATION, Latin American Applied Research. 52(1), 7-13. doi:10.52292/j.laar.2022.738
Others
  1. Fathilah A. Razak, Syarifah Nur S.A. Rahman, Nur Sariyah M. Rosli, Azrin A.A. Rahim, Adyani A.A. Halim and Muhammad Luthfi, 2021. Natural sweetness of fruits may lead to cariogenic oral biofilm: An in vitro study. Pak. J. Nutr., 20: 101-107.
  2. Rizwan, M., Yahya, R., Hassan A., Yar, M., Halim, A.A.A., Al-Maleki, A.R., Shahzadi, L., Zubairi, W. (2019) Novel chitosan derivative based composite scaffolds with enhanced angiogenesis; potential candidates for healing chronic non-healing wounds. Journal of Materials Science: Materials in Medicine, 30(72): Pages 11
  3. Saufi, A.N.M., Ridzwan, N.F.W., Mohamad, S.B., Tayyab, S. and Halim A.A.A. (2019) Fluorometric and docking analysis of the complex formation between an anti-cancer drug, chlorambucil and bovine serum albumin. Indian Journal of Pharmaceutical Education and Research, 53(4), 681-686.
  4. Halim, A.A.A., Kadir, H.A. & Tayyab, S. (2017) Increased chemical stability of Bacillus licheniformis alpha-amylase upon acetylation. Studia UBB Chemia, LXII, 2, Tom II, 319-332.
  5. Halim, A.A.A., Zaroog, M.S., Kadir, H.A. & Tayyab, S. (2017) Alcohol-induced structural transitions in the acid-denatured Bacillus licheniformis alpha-amylase. Journal of Saudi Chemical Society, 21, S349-S358.
  6. Selvanathan, V., Azzahari, A.D., Abd Halim, A.A., Yahya, R. ( 2017). Ternary natural deep eutectic solvent (NADES) infused phthaloyl starch as cost efficient quasi-solid gel polymer electrolyte. Carbohydrate Polymers, 167, 210-218.
  7. Sakhaei, N., Halim, A.A.A. & Tayyab, S. 2015. Warfarin binding to native and structurally-altered human serum albumins. Indian Journal of Pharmaceutical Education and Research 49(3): 225-230.
  8. Halim, A.A.A., Zaroog, M.S., Kadir, H.A. & Tayyab, S. 2014. Molten globule-like partially folded state of Bacillus licheniformis alpha-amylase at low pH induced by 1,1,1,3,3,3-hexafluoroisopropanol. Scientific World Journal 2014, Article ID 824768: 9 pages
  9. Halim, A.A.A., Feroz, S.R. & Tayyab, S. 2013. Does recovery in the spectral characteristics of GdnHCl- denatured Bacillus licheniformis alpha amylase due to added calcium point towards protein stabilization? Bioscience, Biotechnology and Biochemistry 77(1): 87- 96.
  10. Sidek, N.A.A., Halim, A.A.A., Kadir, H.A. & Tayyab, S. 2013. Structural stability of commercial ficin under different denaturing conditions. Turkish Journal of Biochemistry 38(3): 319-328.
  11. Sidek, N.A.A., Halim, A.A.A. & Tayyab, S. 2010. Denatured states of ficin induced by urea and guanidine hydrochloride. Turkish Journal of Biochemistry 35(1): 45-49.
  12. Halim, A.A.A., Kadir, H.A. & Tayyab, S. 2008. Bromophenol blue binding as a probe to study urea and guanidine hydrochloride denaturation of bovine serum albumin. Journal of Biochemistry 144: 33-38.
  13. Halim, A.A.A., Kadir, H.A. & Tayyab, S. 2008. Guanidine hydrochloride-induced denaturation of bovine serum albumin: A comparative study and analysis using different probes. Malaysian J. Sci. 27 (2): 9-17.

RESEARCH PROJECT

National
  1. 2020 - 2025, Fundamental Research Grant Scheme (FRGS)
    Evaluation Of The Properties Of Lactobacillus Helveticus On The Fimbriae Genes Of Porphyromonas Gingivalis In Subgingival Biofilm Associated With Periodontitis ( Co-Researcher)
  2. 2020 - 2024, Fundamental Research Grant Scheme (FRGS)
    Characterisation On The Interaction Of Potential Gingipain Inhibitor Drugs With Human Serum Albumin ( Principal Investigator(PI))
  3. 2018 - 2021, RU Geran - Fakulti Program
    Interaction Of Various Cystein Protease And Wnt/b-catenin Inhibitors With Human Serum Albumin: Spectroscopic And Molecular Modelling Approach ( Principal Investigator(PI))

PAPER PRESENTED

INVITED SPEAKER
  1. Application of Natural Resources in Dentistry, International Summer Course, Fakultas Kedokteran Gigi, Universitas Sumatera Utara (International) (03 Jul 2023 - 04 Jul 2023)
ORAL PRESENTER
  1. Interactions between Malaboricone-A and human serum albumin, MI-PHARMCONFERENCE 2023, Faculty of Pharmacy and Biomedical Sciences (University) (06 Oct 2023 - 07 Oct 2023)
  2. Exploring the interactions of ethyl 4-methoxycinnamate and human serum albumin, MI-PHARMCONFERENCE 2023, Faculty of Pharmacy and Biomedical Sciences (University) (06 Oct 2023 - 07 Oct 2023)
  3. Interactions between malaboricone-c and human serum albumin, MI-PHARMCONFERENCE 2023, Faculty of Pharmacy and Biomedical Sciences (University) (06 Oct 2023 - 07 Oct 2023)
  4. Ungku Ismail, U.F.W., Yosri, A., Syed Abdul Rahman, S.N., & Halim, A.A.A. Effect of a therapeutic flavonoid on the morphology and growth of hydroxyapatite crystals , 12th National Dental Students Scientific Conference , NDSSC 2020  (National) (02 Nov 2020 - 02 Nov 2020)
  5. Thermal and Urea Denaturation Studies of Native and Acetylated Bacillus licheniformis Alpha Amylase, 18th Biological Sciences Graduate Congress, 18th Biological Sciences Graduate Congress (International) (06 Jan 2014 - 07 Jan 2014)
POSTER PRESENTER
  1. Interactions Between Malabaricone-A and Human Serum Albumin, The 33rd Intervarsity Biochemistry Seminar, Fakulti Sains dan Teknologi (University) (09 Dec 2023 - 09 Dec 2023)
  2. Interactions Between Malabaricone-C and Human Serum Albumin, The 33rd Intervarsity Biochemistry Seminar, Fakulti Sains dan Teknologi (National) (09 Dec 2023 - 09 Dec 2023)
  3. Mohd Asngari, N.J., Abdul Razak, F., & Halim, A.A.A. Fluorescence study on the interaction of cysteine protease inhibitor, odanacatib with human serum albumin. , 3rd ICOMOI 2020 & 13th POSTGRADUATE CONFERENCE 2020, Malaysian Society of Oral Microbiology and Oral Immunology (International) (08 Sep 2020 - 09 Sep 2020)
  4. Effect of a therapeutic flavonoid on the morphology and growth of hydroxyapatite crystals, 21st Dental Students' Scientific Conference, Faculty of Dentistry, University of Malaya (University) (11 Mar 2020 - 11 Mar 2020)
  5. Differential Stabilizing Effects of Buffers on Structural Stability of Bovine Serum Albumin Against Urea Denaturation , 30th Intervarsity Biochemistry Seminar, University of Nottingham Malaysia (National) (04 May 2019 - 04 May 2019)
  6. Partial refolding of Bacillus licheniformis alpha-amylase (BLA) Induced by Halogenols and Alkanols at Low pH, 17th Biological Sciences Graduate Congress, 17th Biological Sciences Graduate Congress (International) (08 Dec 2012 - 10 Dec 2012)
  7. Does recovery in the spectral characteristics of GdnHCl-denatured Bacillus lichenformis alpha-amylase (BLA) by added calcium point towards protein stabilization?, 9th International Conference on Protein Stabilizati, 9th International Conference on Protein Stabilizati (International) (02 May 2012 - 04 May 2012)
  8. Calcium-induced stabilization of Bacillus licheniformis alpha-amylase, 36th Annual Conference of the Malaysian Society for Biochemistry & Molecular Biology, Malaysian Society for Biochemistry & Molecular Biology (National) (27 Jul 2011 - 28 Jul 2011)
  9. Probing urea and guanidine hydrochloride denaturation of bovine serum albumin with erythrosin B binding, 33rd Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, Malaysian Society for Biochemistry and Molecular Biology (National) (27 Aug 2008 - 28 Aug 2008)
  10. Guanidine hydrochloride-induced denaturation of bovine serum albumin: A comparative study and analysis using different probes, 32nd Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, Malaysian Society for Biochemistry and Molecular Biology (National) (05 Sep 2007 - 06 Sep 2007)

SUPERVISION

Postgraduate Student
PhD/ Doctoral
  1. (2024) SPECTROSCOPIC CHARACTERIZATION OF THE INTERACTION BETWEEN ANTI-DIABETIC’S DRUGS AND HUMAN SERUM ALBUMIN, FAZAL REHMAN
  2. (2024) ANTIPROLIFERATIVE EFFECTS OF CURCUMA PURPURASCENS ON ORAL SQUAMOUS CELL CARCINOMA AND IT’S INTERACTION MECHANISM WITH HUMAN SERUM ALBUMIN, NURUL JANNAH BINTI MOHD ASNGARI
  3. (2024) CHARACTERISATION ON THE INTERACTION OF SELECTED ANTI-INFLAMMATORY DRUGS AND COMPOUNDS WITH HUMANSERUM ALBUMIN BASED ON In vitro AND In silico APPROACHES, AHMAD FADHLURRAHMAN BIN AHMAD HIDAYAT
  4. (2023) Targeting Mode of Binding Between Virus Inhibitors and Human Serum Albumin in Hepatitis B and C Through Spectroscopic and Molecular Modeling Approaches, MUJAHEED ABUBAKAR
Master
  1. (2023) Exploring Molecular Recognition Between an Antineoplastic Drug, Floxuridine, and Human Serum Albumin Through Spectroscopic, Computational and Atomic Force Microscopic Approaches, FAZAL REHMAN
  2. (2019) Underlying mechanism of antitumor effects of Curcuma purpurascens extracts on oral squamous cell carcinoma (OSCC), NURUL JANNAH BINTI MOHD ASNGARI
Under Graduate Students
  1. (2022) Biocompatibility of hydroxyapatite-nanoparticle of Bosenbergia rotunda - NURUL ILLYANA BINTI MOHAMAD RISTAK
  2. (2022) Biocompatibility of hydroxyapatite-nanoparticle of Bosenbergia rotunda - MUHAMMAD AKMALHAKIM BIN AHMAD KAMIL
  3. (2022) BIOACTIVITIES OF HYDROXYAPATITE COATED WITH TUALANG HONEY ON MEDICATION-RELATED OSTEONECROSIS OF THE JAW (MRONJ) - MUHAMMAD SYAZWAN BIN AHMAD FAUZI
  4. (2022) BIOACTIVITIES OF HYDROXYAPATITE COATED WITH TUALANG HONEY ON MEDICATION-RELATED OSTEONECROSIS OF THE JAW (MRONJ) - MUHAMMAD SYAFIQ BIN AHMAD SABRI
  5. (2021) Influence of various type of foods on the expression and activity of salivary alpha-amylase - Khairul Nabila Rashidi
  6. (2021) Influence of various type of foods on the expression and activity of salivary alpha-amylase - Abbas bin Harith

TEACHING

Master
  1. (2023) DXGC6180 - Kursus Sains Asas Perubatan (Bms) Sesi 2022/2023, Fakulti Pergigian
Bachelor
  1. (2023) DIA1001 - Oral Biology
  2. (2022) - - Cased Based Learning
  3. (2022) DIA1001 - Oral Biology
  4. (2022) - - Problem Based Learning
  5. (2021) DIA1001 - Oral Biology
  6. (2021) PBL - Prblem Based Learning

SOCIAL RESPONSIBILITY ACTIVITIES

  • Umhakcs 4.0 Volunteer, (12 Apr 2021 - 07 May 2021) (University)
  • Colon Cancer Awareness Virtual Run, (10 Dec 2020 - 31 Jan 2021)
  • Sumbangan Kemasyarakatan Untuk Projek Ramadhan Donation Drive 2019 Kepada Pelajar B40 Fakulti Pergigian, Universiti Malaya, (13 May 2019 - 31 May 2019)