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CURRICULUM VITAE
PERSONAL DETAIL

Name
  Prof. Dr. Kam Toh Seok
Designation
  Professor
Department
  Department of Chemistry
Faculty
  Faculty of Science
Tel. No. (Office)
  79674266
E-mail Address
  tskam@um.edu.my
ResearcherID Link
  http://www.researcherid.com/rid/B-8732-2010
Address(Office)
  Department of Chemistry, Faculty of Science Building, University of Malaya, 50603 Kuala Lumpur, MALAYSIA

ACADEMIC QUALIFICATION
(Qualification), (Institution).
PHD, UNIVERSITY OF MALAYA (UM)
BSC(1974) (UM), UNIVERSITY OF MALAYA (UM)

PROFESSIONAL AFFILIATION/MEMBERSHIP
(Organisation), (Role), (Year), (Level).

UNIVERSITY OF MALAYA, ORGANIC/ORGANOMETALLIC RESEARCH GROUP, HEAD, Head, Organic/Organometallic Research Group under the AFR Cluster, 2011-2011

CHEMISTRY - AN ASIAN JOURNAL, INTERNATIONAL EDITORIAL ADVISORY BOARD, Member, International Editorial Advisory Board, 2010-2014, (International)

Malaysian Institute of Chemistry/Institut Kimia Malaysia, Member, 2010, (National)

ADMINISTRATIVE DUTIES
(Role), (Level), (Start date),(End Date).


Head of Organic/Organometallic Research Group under AFR Cluster, University Malaya, 01-Jan-13 - 31-Dec-13

CAREER HISTORY
(Post), (Organisation), (Period).


Professor Vk5 (Contract After Retirement), University of Malaya, 06/12/2010

Professor Vk7 (Contract After Retirement), University of Malaya, 01/12/2005 until 03/12/2010

Professor Vk7, University of Malaya, 11/10/2001 until 09/06/2005

Associate Professor, University of Malaya, 13/04/1990 until 10/10/2001

Lecturer, University of Malaya, 13/05/1980 until 12/04/1990

AREAS OF EXPERTISE
(Area).

Natural Products Chemistry (Natural Products; Alkaloids; Structure; Reactivity; Bioactivity)

Organic Chemical Synthesis (Biomimetic Partial Synthesis; Electroorganic synthesis; Indole derivatives; Oligostilbenoids)

RECENT SELECTED PUBLICATIONS
(Publication).
 
Chapter In Book
 
2008

T. S. Kam and K. H. Lim, Alkaloids of Kopsia. In The Alkaloids: Chemistry and Biology; G. A. Cordell, Ed.; Academic Press: The Netherlands, 2008; Vol. 66, pp. 1 111. 
 
2006

T. S. Kam and Y. M. Choo, Bisindole Alkaloids, in The Alkaloids. Chemistry and Biology, G. A. Cordell (Ed.), Elsevier Inc., 2006, Volume 63, Chapter 4, pp. 181-337. (ISI-Cited Publication)
 
1999

T. S. Kam, Alkaloids from Malaysian Flora, in Alkaloids: Chemical and Biological Perspectives, S. W. Pelletier (Ed.), Pergamon, Amsterdam, 1999, Volume 14, Chapter 2, pp. 285-435. (ISI-Cited Publication)
 
1989

S. H. Goh, K. H. Lee, T. S. Kam and E. Soepadmo, Rutin and alkaloids in Malaysian Uncaria in Flavonoids in Biology and Medicine Das, N. P. (Ed.), 1989, National University of Singapore. 
 
Article In Academic Journals
 
2014

Gan, C. Y.;Yoganathan, K.; Sim, K. S.; Low, Y. Y.; Lim, S. H.; Lim, S. H.; Kam, T. S., Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora, Phytochemistry, 2014, Accepted for publication on 28 August 2014, pending revision. (ISI-Cited Publication)

Tan, S. J.; Lim, J. L.; Low, Y. Y.; Sim, K. S.; Lim, S. H.; Kam, T. S., Oxidized Derivatives of Macroline, Sarpagine, and Pleiocarpamine Alkaloids from Alstonia angustifolia, J. Nat. Prod., 2014, Accepted for publication on 28 July 2014, pending revision. (ISI-Cited Publication)

Raja, V. J.; Lim, K. H.; Leong, C. O.; Kam, T. S.; Bradshaw, T. D., Novel antitumour indole alkaloid, Jerantinine A, evokes potent G2​/M cell cycle arrest targeting microtubules, Invest. New Drugs., 2014, Articles ASAP. (ISI-Cited Publication)

Low, Y. Y.; Hong, F. J.; Lim, K. H.; Thomas, N. F.; Kam, T. S. Transformations of the 2,7-Seco Aspidosperma Alkaloid Leuconolam,Structure Revision of epi- Leuconolam, and Partial Syntheses of Leuconoxine and Leuconodines A and F. J. Nat. Prod., 2014, 77, 327-338. (ISI-Cited Publication)

Hong, F. J.; Low, Y. Y.; Chong, K. W.; Thomas, N. F.; Kam, T. S. Biomimetic Oxidative Dimerization of Anodically Generated Stilbene Radical Cations: Effect of Aromatic Substitution on Product Distribution and Reaction Pathways, J. Org. Chem. 2014, 79, 4528-4543 (ISI-Cited Publication)

Lim, S. H.; Low, Y. Y.; Sinniah, S. K.; Yong, K. T.; Sim, K. S.; Kam, T. S. Macroline, akuammiline, sarpagine, and ajmaline alkaloids from Alstonia Macrophylla, Phytochemistry, 2014, 98, 204-215. (ISI-Cited Publication)

Low, Y. Y.; Gan, C. Y.; Kam, T. S. Andransinine: An Unusual Case of Spontaneous Resolution in an Indole Alkaloid Derivative, J. Nat. Prod., 2014, 77, 1532-1535. (ISI-Cited Publication)
 
2013

Siew-Huah Lim, Yun-Yee Low, G. Subramaniam, Zanariah Abdullah, Noel F. Thomas, Toh-Seok Kam. 2013 (Accepted September, 2012). Lumusidines A-D and villalstonidine F, macroline macroline and macroline pleiocarpamine bisindole alkaloids from Alstonia macrophylla. Phytochemistry 87, 148-156 (ISI-Cited Publication)

Gan, C. Y.; Low, Y. Y.; Thomas, N. F.; Kam, T. S. Rhazinilam−Leuconolam−Leuconoxine Alkaloids from Leuconotis griffithii, J. Nat. Prod., 2013, 76, 957-964. (ISI-Cited Publication)

Nge, C. E.; Gan, C. Y.; Low Y. Y.; Thomas, N. F.; Kam T. S. Voatinggine and tabertinggine, pentacyclic indole alkaloids derived from an iboga precursor via a common cleavamine-type intermediate, Org. Lett., 2013, 15, 4774-4777. (ISI-Cited Publication)
 
2012

S. H. Lim, S. J. Tan, Y. Y. Low, K. H. Lim, N. F. Thomas, T. S. Kam, Perhentidines A C: Macroline-Macroline Bisindoles from Alstonia and the Absolute Configuration of Perhentinine and Macralstonine. J. Natural Products, 2012, 75, 942-950 (ISI-Cited Publication)

S. J. Tan, G. Subramaniam, N. F. Thomas, T. S. Kam, Unusual Nitrogenous Derivatives from Alstonia, Natural Product Communications, 2012, 7, 739-742 (ISI-Cited Publication)

S. J. Tan, K. H. Lim, G. Subramaniam, Toh-Seok Kam. Macroline-sarpagine and macroline-pleiocarpamine bisindole alkaloids from Alstonia angustifolia. Phytochemistry, 2012, accepted for publication, 21 June 2012. (ISI-Cited Publication)

Robert E. Ziegler, Shin-Jowl Tan, Toh-Seok Kam, and John A. Porco Jr. 2012. Development of an Alkaloid Pyrone Annulation: Synthesis of Pleiomaltinine. Angewandte Chemie Int. Ed., 51, 9348-9351 (ISI-Cited Publication)
 
2011

W. S. Yap, C. Y. Gan, Y. Y. Low, Y. M. Choo, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Grandilodines A-C, Biologically Active Indole Alkaloids from Kopsia grandifolia, J. Natural Products, 2011, 74, 1309- 1312. (ISI-Cited Publication)

W. F. Ku, S. J. Tan, Y. Y. Low, K. Komiyama, T. S. Kam, Angustilobine and andranginine type indole alkaloids and an uleine-secovallesamine bisindole alkaloid from Alstonia angustiloba, Phytochemistry, 2011, 72, 2212-2218. (ISI-Cited Publication)

S. J. Tan, W. T. Robinson, K. Komiyama, T. S. Kam, Macrodasine A-G, macroline indole alkaloids incorporating fused spirocyclic tetrahydrofuran-tetrahydrofuran and tetrahydrofuran-tetrahydropyran rings, Tetrahedron, 2011, 67, 3830-3838. (ISI-Cited Publication)

S. H. Lim, S. J. Tan, Y. Y. Low, T. S. Kam, Lumutinines A-D, Linearly Fused Macroline-Macroline and Macroline-Sarpagine Bisindoles from Alstonia macrophylla, J. Natural Products, 2011, 74, 2556-2562. (ISI-Cited Publication)
 
2010

Y. Y. Low, K. H. Lim, Y. M. Choo, H. S. Pang, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Structure, biological activity and biomimetic partial synthesis of the lirofolines, novel pentacylic indole alkaloids from Tabernaemontana, Tetrahedron Letters, 2010, 51, 269-272. (ISI-Cited Publication)

S. J. Tan, Y. M. Choo, N. F. Thomas, W. T. Robinson, K. Komiyama, and T. S. Kam, Unusual indole alkaloid-pyrrole, -pyrone, and carbamic acid adducts from Alstonia angustifolia, Tetrahedron, 2010, 66, 7799- 7806. (ISI-Cited Publication)

S. J. Tan, Y. Y. Low, Y. M. Choo, Z. Abdullah, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Strychnan and secoangustilobine A type alkaloids from Alstonia spatulata. Revision of the C-20 configuration of scholaricine, J. Natural Products, 2010, 73, 1891-1897. (ISI-Cited Publication)

C. Y. Gan, Y. Y. Low, W. T. Robinson, K. Komiyama, and T. S. Kam, Aspidospermatan-aspidospermatan and eburnane-sarpagine bisindole alkaloids from Leuconotis, Phytochemistry, 2010, 71, 1365-1370. (ISI-Cited Publication)

C. Y. Gan, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Leucoridines A D, Cytotoxic Strychnos-Strychnos Bisindole Alkaloids from Leuconotis, J. Natural Products, 2010, 73, 1107-1111. (ISI-Cited Publication)
 
2009

K. H. Lim, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Conolutinine, a Hexacyclic Indole Alkaloid with a Novel Ring System Incorporating a Diazaspiro center and Fused Oxadiazepine-Tetrahydrofuran Rings, Tetrahedron Letters, 2009, 50, 752-754 (ISI-Cited Publication)

C. Y. Gan and T. S. Kam, Leucolusine, a tetracyclic alkaloid with a novel ring system incorporating an oxindole moiety and fused piperidine- tetrahydrofuran rings, Tetrahedron Letters, 2009, 50, 1059-1061. (ISI-Cited Publication)

Lim, K. H., Thomas, N. F., Abdullah, Z. and Kam, T. S. 2009. Seco- tabersonine alkaloids from Tabernaemontana corymbosa. Phytochemistry 70: 424-429. (ISI-Cited Publication)

K. H. Lim and T. S. Kam, Conomicidines A and B, Unusual Alkaloid- Hydroxycinnamyl Alcohol Conjugates from Tabernaemontana corymbosa, Helvetica Chimica Acta, 2009, 92, 1895-1902. (ISI-Cited Publication)

K. H. Lim, K. M. Sim, and T. S. Kam, Four tetracyclic oxindole alkaloids and a taberpsychine derivative from a Malayan Tabernaemontana, Phytochemistry, 2009, 70, 1182 1186 (ISI-Cited Publication)

K. H. Lim and T. S. Kam, Conoliferine and isoconoliferine, structurally novel alkaloid-lignan conjugates from Tabernaemontana corymbosa, Tetrahedron Letters, 2009, 50, 3756-3759 (ISI-Cited Publication)

Y. Y. Low, G. Subramaniam, K. H. Lim, R. C. S. Wong, Ward T. Robinson, and T. S. Kam, Mersiphyllines A and B from Kopsia. Determination of relative configuration at a quaternary center via formation of an alkaloid- borane complex, Tetrahedron, 2009, 65, 6873-6876 (ISI-Cited Publication)

C. Y. Gan, W. T. Robinson, T. Etoh, M. Hayashi, K. Komiyama, and T. S. Kam, Leucophyllidine, a cytotoxic bisindole alkaloid constituted from the union of a eburnan and a novel vinylquinoline alkaloid, Organic Letters, 2009, 11, 3962-3965. (ISI-Cited Publication)

Gan, C. Y., Low, Y. Y., Etoh, T., Hayashi, M., Komiyama, K., and Kam, T. S. Leuconicines A G and (−)-Eburnamaline, Biologically active strychnan and eburnan alkaloids from Leuconotis. J. Nat. Prod., 2009, 72, 2098- 2103. (ISI-Cited Publication)
 
2008

T. S. Kam, S. J. Tan, S. W. Ng, and K. Komiyama, Bipleiophylline, an Unprecedented Cytotoxic Bisindole Alkaloid Constituted from the Bridging of Two Indole Moities by an Aromatic Spacer Unit, Organic Letters, 2008, 10, 3749-3752. (ISI-Cited Publication)

K. H. Lim, O. Hiraku, K. Komiyama, and T. S. Kam, Jerantinines A G, Cytotoxic Aspidosperma Alkaloids from Tabernaemontana corymbosa, J. Natural Products, 2008, 71, 1591-1594. (ISI-Cited Publication)

K. H. Lim, Y. Y. Low, G. H. Tan, T. M. Lim, and T. S. Kam, Kopsine and Danuphylline Alkaloids from Kopsia. Biomimetic Partial Synthesis of Danuphylline B, Helvetica Chimica Acta, 2008, 91, 1559-1566. (ISI-Cited Publication)

S. H. Lim, K. Mahmood, K. Komiyama, and T. S. Kam, A Cycloartane Incorporating a Fused Tetrahydrofuran Ring and a Cytotoxic Lactam from Monocarpia marginalis, J. Natural Products, 2008, 71, 1104-1106. (ISI-Cited Publication)

G. Subramaniam, Y. M. Choo, O. Hiraku, K. Komiyama, and T. S. Kam, The alkaloids of the mersinine group: a new subclass of the monoterpenoid indole alkaloids from Kopsia, Tetrahedron, 2008, 64, 1397-1408. (ISI-Cited Publication)

K. H. Lim and T. S. Kam, Methyl chanofruticosinate alkaloids from Kopsia arborea, Phytochemistry, 2008, 69, 558-561. (ISI-Cited Publication)

G. Subramaniam, O. Hiraku, M. Hayashi, T. Koyano, K. Komiyama, and T. S. Kam, Biologically active aspidofractinine alkaloids from Kopsia singapurensis, J. Natural Products, 2008, 71, 53-57. (ISI-Cited Publication)

G. Subramaniam and T. S. Kam, New indole alkaloids from Kopsia. Alkaloid variation in K. singapurensis, Helv. Chim. Acta, 2008, 91, 930-937. (ISI-Cited Publication)

Siew-Huah Lim, Kamaliah Mahmood, Kanki Komiyama and Toh-Seok Kam, A Cycloartane Incorporating a Fused Tetrahydrofuran Ring and a Cytotoxic Lactam from Monocarpia marginalis, J. Nat. Prod. 2008, 71, 1104- 1106 
 
2007

K. H. Lim, K. Komiyama, and T. S. Kam, Arboricine and arboricinine, unusual tetracyclic indole regioisomers from Kopsia, Tetrahedron Letters, 2007, 48, 1143-1145. (ISI-Cited Publication)

K. H. Lim and T. S. Kam, Seco-leuconoxine and oxo-pericine derivatives from Kopsia, Helvetica Chimica Acta, 2007, 90, 31-35. (ISI-Cited Publication)

G. Subramaniam and T. S. Kam, Mersinaline and mersirachine, novel quinolinic alkaloids of the mersinine group from Kopsia, Tetrahedron Letters, 2007, 48, 6677-6680. (ISI-Cited Publication)

S. H. Lim, K. M. Sim, Z. Abdullah, O. Hiraku, M. Hayashi, K. Komiyama, and T. S. Kam, Leuconoxine, kopsinitarine, kopsijasmine, and kopsinone derivatives from Kopsia, J. Natural Products, 2007, 70, 1380-1383. (ISI-Cited Publication)

K. H. Lim, O. Hiraku, K. Komiyama, T. Koyano, M. Hayashi, and T. S. Kam, Biologically active indole alkaloids from Kopsia arborea, J. Natural Products, 2007, 70, 1302-1307. (ISI-Cited Publication)

G. Subramaniam, O. Hiraku, M. Hayashi, T. Koyano, K. Komiyama, and T. S. Kam, Biologically active aspidofractinine, rhazinilam, akuammiline, and vincorine alkaloids from Kopsia, J. Natural Products, 2007, 70, 1783-1789. (ISI-Cited Publication)
 
2006

K. H. Lim and T. S. Kam, Arboflorine, an Unusual Pentacyclic Monoterpenoid Indole Alkaloid Incorporating a Third Nitrogen Atom, Organic Letters, 2006, 8, 1733-1735. (ISI-Cited Publication)

K. H. Lim and T. S. Kam, Arbophylline, a novel heptacyclic indole with a cage skeleton incorporating an acetal moiety, Tetrahedron Letters, 2006, 47, 8653-8655. 

K. H. Lim, Y. Y. Low, and T. S. Kam, Biomimetic Oxidative Transformations of Pericine: Partial Synthesis of Apparicine and Valparicine, a New Pentacyclic Indole Alkaloid from Kopsia, Tetrahedron Letters, 2006, 47, 5037-5039. (ISI-Cited Publication)

H. Hasegawa, Y. Yamada, K. Komiyama, M. Hayashi, M. Ishibashi, T. Yoshida, T. Sakai, T. Koyano, T. S. Kam, K. Murata, K. Sugahara, K. Tsuruda, N. Akamatsu, K. Tsukasaki, M. Masuda, N. Takasu, and S. Kamihira, Dihydroflavonol BB-1, an extract of natural plant Blumea balsamifera, abrogates TRAIL resistance in leukemia cells, Blood, 2006, 107, 607-688. (ISI-Cited Publication)
 
2004

T. S. Kam, G. Subramaniam, K. H. Lim, and Y. M. Choo, Mersicarpine, an unusual tetracyclic dihydroindole alkaloid incorporating a seven-membered imine ring, Tetrahedron Letters, 2004, 45, 5995-5998. (ISI-Cited Publication)

T. S. Kam and G. Subramaniam, Mersilongine, an unusual tetracyclic, quinolinic, indole alkaloid from Kopsia, Tetrahedron Letters, 2004, 45, 3521-3524. (ISI-Cited Publication)

T. S. Kam and Y. M. Choo, Angustilodine, an unusual pentacyclic indole from Alstonia, Helvetica Chimica Acta, 2004, 87, 366-369. (ISI-Cited Publication)

T. S. Kam, Y. M. Choo, and K. Komiyama, Unusual spirocyclic macroline alkaloids, nitrogenous derivatives, and a cytotoxic bisindole from Alstonia, Tetrahedron, 2004, 60, 3957-3966. (ISI-Cited Publication)

T. S. Kam and Y. M. Choo, New indole alkaloids from Alstonia macrophylla, J. Natural Products, 2004, 67, 547-552. (ISI-Cited Publication)

T. S. Kam and Y. M. Choo, Kopsifolines A F, A new structural class of monoterpenoid indole alkaloids from Kopsia, Helvetica Chimica Acta, 2004, 87, 991-998. (ISI-Cited Publication)

T. S. Kam and H. S. Pang, Conodusarine, a new biologically active bisindole alkaloid from Tabernaemontana divaricata, Heterocycles, 2004, 63, 845-850. (ISI-Cited Publication)

T. S. Kam, P. S. Pang, Y. M. Choo, and K. Komiyama, Biologically active ibogan and vallesamine derivatives from Tabernaemontana, Chemistry and Biodiversity, 2004, 1, 646-656. (ISI-Cited Publication)

T. S. Kam and Y. M. Choo, Alkaloids from Alstonia angustifolia, Phytochemistry, 2004, 65, 603-608. (ISI-Cited Publication)

T. S. Kam, and Y. M. Choo, Venalstonine and dioxokopsan derivatives from Kopsia, Phytochemistry, 2004, 65, 2119-2122. (ISI-Cited Publication)

T. S. Kam, K. M. Sim, H. S. Pang, M. Hayashi, and K. Komiyama, Cytotoxic effects and reversal of multidrug resistance by ibogan and related alkaloids, Bioorganic and Medicinal Chemistry Letters, 2004, 14, 4487-4489. (ISI-Cited Publication)

T. S. Kam, K. H. Lim, K. Yoganathan, M. Hayashi, K. Komiyama, Lundurines A-D, cytotoxic indole alkaloids incorporating a cyclopropyl moiety from Kopsia tenuis and revision of the structures of tenuisines A-C, Tetrahedron, 2004, 60, 10739-10745. (ISI-Cited Publication)
 
2003

T. S. Kam, H. S. Pang, and T. M. Lim, Biologically active indole and bisindole alkaloids from Tabernaemontana divaricata, Organic and Biomolecular Chemistry, 2003, 1, 1292-1297. (ISI-Cited Publication)

T. S. Kam and Y. M. Choo, Macrodasine A, a novel macroline derivative incorporating fused spirocyclic tetrahydrofuran rings containing a spiroacetal moiety, Tetrahedron Letters, 2003, 44, 8787-8789. (ISI-Cited Publication)

T. S. Kam and Y. M. Choo, Kopsifolines A, B, and C, novel indole alkaloids with a hexacyclic carbon skeleton from Kopsia, Tetrahedron Letters, 2003, 44, 1317-1319. (ISI-Cited Publication)

T. S. Kam and K. M. Sim, Conodirinines A and B, novel vobasine-iboga bisindoles incorporating an additional tetrahydrooxacine unit on the vobasinyl moiety, Helvetica Chimica Acta, 2003, 86, 122-126. (ISI-Cited Publication)

T. S. Kam, K. M. Sim, and H. S. Pang, New Bisindoles from Tabernaemontana corymbosa, J. Natural Products, 2003, 66, 11-16. (ISI-Cited Publication)

K. Umezawa, A. Hiroki, M. Kawakami, H. Naka, I. Takei, T. Ogata, I. Kojima, T. Koyano, T. Kowithayakorn, H. S. Pang, and T. S. Kam, Induction of insulin production in rat pancreatic acinar carcinoma cells by conophylline, Biomedicine and Pharmacotherapy, 2003, 57, 341-350. (ISI-Cited Publication)

T. S. Kam and K. M. Sim, Conodurine, conoduramine and ervahanine derivatives from Tabernaemontana, Phytochemistry, 2003, 63, 625-629. (ISI-Cited Publication)

G. Subramaniam, T. S. Kam, and S. W. Ng, Mersinine A from Kopsia fruticosa, Acta Crystallographica, 2003, E59, o555-o557. (ISI-Cited Publication)
 
2002

T. S. Kam and K. M. Sim, New tabernamine derivatives from Tabernaemontana, Heterocycles, 2002, 57, 2137-2143. (ISI-Cited Publication)

T. S. Kam and K. M. Sim, Vobasonidine and Vobatricine, Novel Bisindole Alkaloids from a Malayan Tabernaemontana, Helvetica Chimica Acta, 2002, 85, 1027-1032. (ISI-Cited Publication)

T. S. Kam and K. M. Sim, Five New Iboga Alkaloids from Tabernaemontana corymbosa, J. Natural Products, 2002, 65, 669-672. (ISI-Cited Publication)
 
2001

T. S. Kam, T. M. Lim, and G. H. Tan, Electrochemical Oxidation of Aspidofractinine-type Alkaloids: Formation of Kopsine, Kopsidine, Kopsinitarine, and Bisindole Derivatives, Journal of the Chemical Society, Perkin Transactions 1, 2001, 1594-1604. (ISI-Cited Publication)

T. S. Kam, K. M. Sim, and T. M. Lim, Voastrictine, a Novel Pentacyclic Quinolinic alkaloid from Tabernaemontana, Tetrahedron Letters, 2001, 42, 4721-4723. (ISI-Cited Publication)

T. S. Kam, G. Subramaniam, and T. M. Lim, Mersinines A and B and Mersiloscine, Novel Quinolinic Alkaloids from Kopsia, Tetrahedron Letters, 2001, 42, 5977-5980. (ISI-Cited Publication)

T. S. Kam and K. M. Sim, Dippinines A - D, New Iboga-derived Alkaloids from Tabernaemontana, Heterocycles, 2001, 55, 2405-2412. (ISI-Cited Publication)
 
2000

T. S. Kam, K. M. Sim, and T. M. Lim, Tronocarpine, a novel pentacyclic indole incorporating a seven-membered lactam moiety, Tetrahedron Letters, 2000, 41, 2733-2736. (ISI-Cited Publication)

T. S. Kam and Y. M. Choo, Novel macroline-oxindoles from a Malayan Alstonia, Tetrahedron, 2000, 56, 6143-6150. (ISI-Cited Publication)
 
1999

T. S. Kam, T. M. Lim and Y. M. Choo, Structure and Biomimetic, Electrochemically-mediated Semisynthesis of the Novel Pentacyclic Indole Danuphylline, Tetrahedron, 1999, 55, 1457-1468. (ISI-Cited Publication)

T. S. Kam, T. M. Lim and G. H. Tan, Unprecedented cyanation and cyanomethylation following ring closure versus dimer formation in the anodic oxidation of the aspidofractinine alkaloid kopsamine, Heterocycles, 1999, 51, 249-253. (ISI-Cited Publication)

T. S. Kam and K. M. Sim, Dippinine C, A New Hexacyclic Chippiine Derivative from a Malayan Tabernaemontana, Heterocycles, 1999, 51, 345-348. (ISI-Cited Publication)

T. S. Kam, G. Subramaniam and W. Chen, Alkaloids from Kopsia dasyrachis, Phytochemistry, 1999, 51, 159-169. (ISI-Cited Publication)

T. S. Kam and K.M. Sim, Dippinine A, A New Alkaloid of the Chippiine-type from a Malayan Tabernaemontana, Natural Product Letters, 1999, 13, 143-146. (ISI-Cited Publication)

M. C. Rho, M. Toyoshima, M. Hayashi, T. Koyano, G. Subramaniam, T. S. Kam and K. Komiyama, Reversal of Multidrug Resistance by Kopsiflorine from Kopsia dasyrachis, Planta Medica, 1999, 65, 307-310. (ISI-Cited Publication)

T. S. Kam, I. H. Iek and Y. M. Choo, Alkaloids from the stem-bark of Alstonia macrophylla, Phytochemistry, 1999, 51, 839-844. (ISI-Cited Publication)

T. S. Kam, Y. M. Choo, W. Chen and J. X. Yao, Indole and monoterpene alkaloids from the leaves of Kopsia dasyrachis, Phytochemistry, 1999, 52, 959-963. (ISI-Cited Publication)

T. S. Kam, K. M. Sim, T. Koyano and K. Komiyama, Leishmanicidal alkaloids from Kopsia griffithii, Phytochemistry, 1999, 50, 75-79. (ISI-Cited Publication)

T. S. Kam, T. M. Lim, Y. M. Tee, G. Subramaniam and K. Yoganathan, 17-alpha-hydroxy-14,15-dehydrokopsinine and a bisindole alkaloid from a Malayan Kopsia, Phytochemistry, 1999, 50, 171-175. (ISI-Cited Publication)
 
1998

T. S. Kam, K. M. Sim, T. Koyano, M. Toyoshima, M. Hayashi and K. Komiyama, Conodiparines A-D, New bisindoles from Tabernaemontana. Reversal of vincristine-resistance with cultured cells, Bioorganic and Medicinal Chemistry Letters, 1998, 8, 1693-1696. (ISI-Cited Publication)

T. S. Kam, T. M. Lim, Y. M. Choo and G. Subramaniam, Danuphylline, a novel pentacyclic indole from Kopsia, Tetrahedron Letters, 1998, 39, 5823-5826. (ISI-Cited Publication)

T. S. Kam, G. Subramaniam, K. M. Sim, K. Yoganathan, T. Koyano, M. Toyoshima, M. C. Rho, M. Hayashi and K. Komiyama, Reversal of Multidrug Resistance (MDR) by Aspidofractinine-type Indole Alkaloids, Bioorganic and Medicinal Chemistry Letters, 1998, 8, 2769-2772. (ISI-Cited Publication)

T. S. Kam, K. M. Sim, T. Koyano, M. Toyoshima, M. Hayashi and K. Komiyama, Cytotoxic and leishmanicidal aminoglycosteroids and aminosteroids from Holarrhena curtisii, J. Natural Products, 1998, 61, 1332-1336. (ISI-Cited Publication)

T. S. Kam, G. Subramaniam and W. Chen, 19(R)-Hydroxyeburnamine and 19(R)-hydroxyisoeburnamine from Kopsia dasyrachis, Natural Product Letters, 1998, 12, 293-298. (ISI-Cited Publication)

T. S. Kam, Y. M. Tee and G. Subramaniam, Rhazinal, a formylrhazinilam derivative from a Malayan Kopsia, Natural Product Letters, 1998, 12, 307-310. (ISI-Cited Publication)

T. S. Kam and G. Subramaniam, Oxo-derivatives of kopsine- and rhazinilam-type alkaloids from a North Borneo Kopsia, Natural Product Letters, 1998, 11, 131-136. (ISI-Cited Publication)

S. L. Mok, K. Yoganathan, T. M. Lim and T. S. Kam, Cardiovascular Effects of Aspidofractinine-type Indole Alkaloids from Kopsia. J. Natural Products, 1998, 61, 328-332. (ISI-Cited Publication)

W. Chen, S. Anuradha and T. S. Kam, Crystal structure of conofoline, Zeitschrift fur Kristallographie, 1998, 213, 183-184. (ISI-Cited Publication)

T. S. Kam and K. M. Sim, Alkaloids from Kopsia griffithii, Phytochemistry, 1998, 47, 145-147. (ISI-Cited Publication)

C. H. Chuah, T. S. Kam and S. W. Ng, Crystal structure of N-methoxycarbonyl-11,12-methylenedioxy-16,17-dehydro-kopsinine, C24H26N2O6, Zeitschrift fur Kristallographie, 1998, 213, 163-165. (ISI-Cited Publication)

T. S. Kam, S. Anuradha, K. Takahashi, T. Koyano and K. Komiyama, Anticancer agents containing conofoline for treatment of multidrug-resistant tumours, Japan Kokai, JP10007567, 1998. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan, K. Takahashi, T. Koyano and Kanki Komiyama, Lundurine B as a melanoma inhibitor, Japan Kokai, JP10045760, 1998. (ISI-Cited Publication)

T. S. Kam, S. Anuradha, T. M. Lim, K. Takahashi, T. Koyano and K. Komiyama, Conophylline quinone as a new antitumour agent, Japan Kokai, JP10045763, 1998. (ISI-Cited Publication)
 
1997

T. S. Kam, R. Jayashankar, K. M. Sim and K. Yoganathan, Angustimaline, an unusual nitrogenous compound from Alstonia angustifolia, Tetrahedron Letters, 1997, 38, 477-478. (ISI-Cited Publication)

T. S. Kam and K. Yoganathan, Nitaphylline, a new bisindole alkaloid from Kopsia, Natural Product Letters, 1997, 10, 69-74. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan, H. Y. Li and N. Harada, Tenuisines A - C and Tenuiphylline, novel bisindoles from Kopsia tenuis, Tetrahedron, 1997, 53, 12661-12670. (ISI-Cited Publication)

T. S. Kam and K. Yoganathan, Lahadinines A and B, new cyano-substituted indole alkaloids from Kopsia pauciflora, Phytochemistry, 1997, 46, 785-787. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan and S. L. Mok, Aspidofractinine alkaloids from Kopsia teoi, Phytochemistry, 1997, 46, 789-792. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan and Chen Wei, Monoterpene alkaloids from Kopsia pauciflora, J. Natural Products, 1997, 60, 673-676. (ISI-Cited Publication)

T. S. Kam, K. T. Nyeoh, K. M. Sim and K. Yoganathan, Alkaloids from Alstonia scholaris, Phytochemistry, 1997, 45, 1303-1305. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan and C. H. Chuah, Four heptacyclic indoles from Kopsia teoi, Phytochemistry, 1997, 45, 623-625. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan, H. Takahashi, T. Koyano and K. Komiyama, Pauciflorines A and B as melanin formation inhibitors, Japan Kokai, JP09255683, 1997. (ISI-Cited Publication)
 
1996

T. S. Kam, K. Yoganathan and H. Y. Li, Tenuisines A, B and C, Novel bisindoles with C2 symmetry from Kopsia tenuis, Tetrahedron Letters, 1996, 37, 8811-8814. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan and Chen Wei, Paucidactine A and B, new indole alkaloids with a novel ring system containing a lactone moiety, Tetrahedron Letters, 1996, 37, 3603-3606. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan, T. Koyano and K. Komiyama, Pauciflorine A and B, Novel Melanin Biosynthesis Inhibitors from Kopsia, Tetrahedron Letters, 1996, 37, 5765-5768. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan and Chen Wei, Novel cage indoles from a Malaysian Kopsia, J. Natural Products, 1996, 59, 1109-1112. (ISI-Cited Publication)

T. S. Kam and K. Yoganathan, Three Aspidofractinine Alkaloids from Kopsia, Phytochemistry, 1996, 42, 539-541. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan and Chen Wei, Kinabalurine A, a new monoterpene alkaloid from Kopsia, Natural Product Letters, 1996, 8, 231-235. (ISI-Cited Publication)

T. S. Kam, S. Anuradha and K. Y. Loh, Voafinidine and voalenine, novel indoles of the aspidosperma-type from Tabernaemontana, Natural Product Letters, 1996, 8, 49-53. (ISI-Cited Publication)

A. Ali, G. B. Gill, G. Pattenden, G. A. Roan and T. S. Kam, Palladium and Cobalt Mediated cyclizations of Halo-Polyenes: A Comparative Study, J. Chem. Soc., Perkin Trans. 1, 1996, 1081-1093. (ISI-Cited Publication)

T. S. Kam, Lalitha Arasu and K. Yoganathan, Alkaloids from the stem of Kopsia pauciflora, Phytochemistry, 1996, 43, 1385-1387. (ISI-Cited Publication)

J. S. L. Mok, K. Yoganathan and T. S. Kam, Testing for antihypertensive activities of kopsingine and its congenors in spontaneously hypertensive rats, Asia Pacific Journal of Pharmacology, 1996, 11, Suppl. 1, S19. (ISI-Cited Publication)
 
1995

T. S. Kam, K. Yoganathan and C. H. Chuah, Lundurines A, B and C, new indole alkaloids with a novel carbon skeleton containing a cyclopropyl moiety, Tetrahedron Letters, 1995, 36, 759-762. (ISI-Cited Publication)

T. S. Kam, T. M. Lim and G. H. Tan, Electrochemical oxidation of aspidofractinine-type alkaloids. A facile electrochemically-mediated conversion of kopsingine to kopsidines A, B, C and kopsinganol, Tetrahedron Letters, 1995, 36, 1327-1330. (ISI-Cited Publication)

T. S. Kam and P. S. Tan, Dehydropleiocarpine alkaloids from Kopsia profunda, Phytochemistry, 1995, 39, 469-471. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan and W. H. Wong, Novel cage indole alkaloidal artefacts containing an alpha-aminoketone moiety from a Kopsia species, Natural Product Letters, 1995, 5, 309-314. (ISI-Cited Publication)

T. S. Kam and S. Anuradha, Alkaloids from Tabernaemontana divaricata, Phytochemistry, 1995, 40, 313-316. (ISI-Cited Publication)

T. S. Kam and S. Anuradha, Voafinine and N-methylvoafinine, novel aspidosperma alkaloids from Tabernaemontana, Natural Product Letters, 1995, 7, 191-195. (ISI-Cited Publication)
 
1994

T. S. Kam, K. Yoganathan, C. H. Chuah, Kopsinitarines A, B and C, novel cage alkaloids from a Malaysian Kopsia, Tetrahedron Letters, 1994, 35, 4457-4460. (ISI-Cited Publication)
 
1993

T. S. Kam, K. Yoganathan and C. H. Chuah, Kopsidine A and Kopsidine B, two novel indole alkaloids from a Malaysian Kopsia, Tetrahedron Letters, 1993, 34, 1819-1822. (ISI-Cited Publication)

T. S. Kam and T. M. Lim, Electron-transfer versus nucleophilic substitution in the reactions of alpha-halogenated 4-nitrotoluenes with base, J. Chem. Soc., Perkin Trans. 2, 1993, 147-150. (ISI-Cited Publication)

T. S. Kam, P. S. Tan and Chen Wei, Absolute configuration of C-16 of eburnane alkaloids from Kopsia larutensis, Phytochemistry, 1993, 33, 921-924. (ISI-Cited Publication)

T. S. Kam and K. Y. Loh, 5-oxo-19,20-dehydroervatamine from the leaves of Tabernaemontana corymbosa, Phytochemistry, 1993, 32, 1357-1358. (ISI-Cited Publication)

M. C. R. Symons, T. S. Kam, J. Wyatt and T. M. Lim, Electron paramagnetic resonance studies of electron-capture processes. p-Nitrobenzyl and p-nitrobenzylidene systems, J. Chem. Soc., Perkin Trans. 2, 1993, 151-155. (ISI-Cited Publication)

T. S. Kam, P. S. Tan, P. Y. Hoong and C. H. Chuah, Methyl chanofruticosinates from the leaves of Kopsia arborea, Phytochemistry, 1993, 32, 489-491. (ISI-Cited Publication)

T. S. Kam, K. Yoganathan, C. H. Chuah and Chen Wei, Aspidofractinine alkaloids from a new Kopsia species, Phytochemistry, 1993, 32, 1343-1346. (ISI-Cited Publication)

T. S. Kam, K. Y. Loh and Chen Wei, Conophylline and conophyllidine: new dimeric alkaloids from Tabernaemontana divaricata, J. Natural Products, 1993, 56, 1865-71. (ISI-Cited Publication)
 
1992

T. S. Kam, K. Y. Loh, L. H. Lim, W. L. Loong, C. H. Chuah and Chen Wei, New alkaloids from Tabernaemontana divaricata, Tetrahedron Letters, 1992, 33, 969-972. (ISI-Cited Publication)

T. S. Kam, P.S. Tan, C.H. Chuah, Alkaloids from the leaves of Kopsia larutensis, Phytochemistry, 1992, 31, 2936-2938. (ISI-Cited Publication)

T. S. Kam, K. H. Lee, S. H. Goh, Alkaloid distribution in Malaysian Uncaria, Phytochemistry, 1992, 31, 2031-2034. (ISI-Cited Publication)

J. Mok, P. Chang, K. H. Lee, T. S. Kam and S. H. Goh, Cardiovascular responses in the normotensive rat produced by intravenous injection of gambirine isolated from Uncaria callophylla, J. Ethnopharmacol., 1992, 36, 219-223. (ISI-Cited Publication)

S. H. Goh, T. S. Kam, K. H. Lee, J. S. L. Mok and S. L. Oo, A study of the Malaysian medicinal plant Uncaria callophylla, Asean J. Sci. Technol. Develop., 1992, 9 (1): 117-125. (ISI-Cited Publication)
 
1991

T. S. Kam, K. H. Lee, S. H. Goh, Dimeric indole alkaloids from Uncaria callophylla, Phytochemistry, 1991, 30, 3441-3444. (ISI-Cited Publication)
 
1990

T. S. Kam and P. S. Tan, Plumeran alkaloids from Kopsia profunda, Phytochemistry, 1990, 29, 2321-2322. (ISI-Cited Publication)
 
1989

S. H. Goh, F. L. Lai and T. S. Kam, Vitamin E concentrate from palm fatty acid distillate, Malaysian Patent, P. I. No. 8703215 (1989). (SCOPUS-Cited Publication)

Y. M. Choo, A. S. H. Ong, S.H. Goh, T. S. Kam, Recovery of carotenoids, tocopherols, tocotrienols and sterols from esterified palm oil, UK Patent, GB 2218989 (1989). (ISI-Cited Publication)
 
1981

S. H. Goh and T. S. Kam, Comparative reactivity of substituted 4-nitrobenzylidene dichlorides with alkali, J. Chem. Soc., Perkin Trans. 1, 1981, 423-426. (ISI-Cited Publication)
 
1978

S. H. Goh and T. S. Kam, Kinetics and mechanism of the reaction of 4-nitrobenzylidene dichloride with hydroxide ion, J. Chem. Soc., Perkin Trans. 2, 1978, 648-652. (ISI-Cited Publication)
 
1975

S. H. Goh, K. C. Chan, T. S. Kam, and H. L. Chong, Dihalocarbene insertions into carbon-hydrogen bonds of hydrocarbons and ethers, Aust. J. Chem., 1975, 28, 381-384. (ISI-Cited Publication)
 
Proceeding
 
1989

T. S. Kam, A synthesis of Z -11-hexadecenol, Z -11-hexadecenal, and Z -11-hexadecenyl acetate, the major components of the sex pheromone of Plutella xylostella, Malaysian Chemical Congress, Kuala Lumpur, 1989, p.6. (SCOPUS-Cited Publication)

AREAS OF RESEARCH
(Project title), (Role), (From)-(Until), (Source), (Level).

Biorganic and Medicinal Chemistry and Organic Synthesis, Principal Investigator(PI), 2011-2015, HIR

Structure, Synthesis, and Evaluation of Bioactive Secondary Metabolites from Plants and Microbes, Principal Investigator(PI), 2011-2012, HIR

Electrochemical oxidation of stilbenes, xanthones and allyl phenols: Investigation of mechanisms and applications in synthesis, Principal Investigator(PI), 2009-2010, Fundamental Research Grant Scheme (FRGS), National

Synthesis and Evaluation of Bioactive Indole, Bisindole, and Oligostibenoid Derivatives, Principal Investigator(PI), 2009-2012, Geran Penyelidikan Universiti Malaya (UMRG), National

Development of biologically active secondary metabolites from microorganisms for potential applications in pharmacotherapy, Principal Investigator(PI), 2009-2010, ScienceFund, National

Electroorganic Chemistry of Indole Derivatives, Principal Investigator(PI), 2008, 

Natural Product Chemistry with special emphasis on Alkaloids, Principal Investigator(PI), 2008, 

Biomimetic Synthesis of Indole Derivatives, Principal Investigator(PI), 2008, 

Biological Activity of Alkaloids and other secondary metabolites with special emphasis on Cancer, Principal Investigator(PI), 2008, 

Natural Product, Principal Investigator(PI), 2008, 

Medicinal Chemistry, Principal Investigator(PI), 2008, 

Bioorganic, Principal Investigator(PI), 2008, 

Investigations of the role of Iminium ions as Key Intermediates in Indole Alkaloid Transformations, Principal Investigator(PI), 2007-2008, Fundamental Research Grant Scheme (FRGS), National

Development, Synthesis, and Evaluation of Bioactive Indole Derivatives for Potential Applications in Biomedicine and Pharmacotherapy, Principal Investigator(PI), 2007-2008, ScienceFund, National

Biomimetic synthesis of novel indole alkaloids from Kopsia and Tabernaemontana, Principal Investigator(PI), 2005-2007, ASM/SAGA, National

Development, synthesis, and evaluation of new chemosensitizers for reversal of multidrug resistance, Principal Investigator(PI), 2003-2005, MOSTI/IRPA, National

Electrochemical reactions and synthesis of bioactive heterocyclic derivatives, Principal Investigator(PI), 2003-2005, MOSTI/IRPA, National

Development of New Raw Materials for Novel Pharmaceuticals, Principal Investigator(PI), 1997-2000, MOSTI/IRPA, National

Electroorganic Synthesis and Mechanisms, Principal Investigator(PI), 1996-1999, MOSTI/IRPA, National

Chemical Investigations of Malaysian Plants for Bioactive Substances, Principal Investigator(PI), 1991-1995, MOSTI/IRPA, National

Chemical Investigations of Malaysian Plants for Cytotoxic and Antihypertensive Constituents, Principal Investigator(PI), 1989-1990, MOSTI/IRPA, National

Development of Therapeutic Substances from Plants (International) Asean-Australian Economic Cooperation Program (AAECP) Biotechnology Project, Co-Investigator, 1989-1994, AIDAB, National

SUPERVISION

 
Post Graduate Level
(Name of Degree), (Name of Candidates), (Title of Thesis), (Academic Session)

Others

Masters Degree, Lee Kee Huat, Alkaloids from Malaysian Uncaria

Masters Degree, Lim Tuck Meng, Electron Transfer Reactions of Nitrobenzylic Derivatives

Masters Degree, Pang Huey Shen, Biologically Active Indole and Bisindole Alkaloids from Tabernaemontana Divaricata

Masters Degree, Tan Poh Suan, Alkaloids from Malaysian Kopsia Species

Doctoral Degree (PhD), Choo Yeun Mun, Studies in Alkaloid Chemistry: Structure, Reactivity and Biological Activity of Alkaloids from Alstonia and Kopsia

Doctoral Degree (PhD), G. Subramaniam, Biologically Active Indole and Bisindole Alkaloids from Kopsia

Doctoral Degree (PhD), K. Yoganathan, Alkaloids from Malaysian Kopsia. Chemistry and Bioactivity

Doctoral Degree (PhD), Lim Tuck Meng, Structure and Electroorganic Chemistry of some Indole Derivatives

Doctoral Degree (PhD), Sim Kooi Mow, Alkaloids from Holarrhena, Kopsia, and Tabernaemontana. Chemistry and Bioactivity

Completed

Masters Degree, Lim Siew Huah, Biologically Active Constituents from Kopsia and Monocarpia

Masters Degree, Low Yun Yee, Biomimetic Partial Synthesis of Some Indole Derivatives, 2005/2006

Doctoral Degree (PhD), Lim Kuan Hon, Biologically Active Indole and Bisindole Alkaloids from Kopsia and Tabernaemontana